changeset 3:3c40b02934ad draft default tip

Uploaded
author saketkc
date Tue, 07 Oct 2014 18:56:07 -0400
parents f8f4ad14f5a6
children
files polyphen2_web/polyphen2_web.py polyphen2_web/polyphen2_web.xml polyphen2_web/test-data/chasm_input.txt polyphen2_web/test-data/ma_empty.csv polyphen2_web/test-data/ma_nucleotide_output.csv polyphen2_web/test-data/ma_proper_nucleotide.csv polyphen2_web/test-data/ma_proper_protein.csv polyphen2_web/test-data/ma_proper_protein.tsv polyphen2_web/test-data/ma_protein_output.csv polyphen2_web/test-data/polyphen_input.txt polyphen2_web/test-data/polyphen_output_full.tsv polyphen2_web/test-data/polyphen_output_log.tsv polyphen2_web/test-data/polyphen_output_short.tsv polyphen2_web/test-data/polyphen_output_snp.tsv polyphen2_web/tool_dependencies.xml
diffstat 14 files changed, 123 insertions(+), 36 deletions(-) [+]
line wrap: on
line diff
--- a/polyphen2_web/polyphen2_web.py	Mon Apr 14 17:50:33 2014 -0400
+++ b/polyphen2_web/polyphen2_web.py	Tue Oct 07 18:56:07 2014 -0400
@@ -11,10 +11,9 @@
 submission_url = 'http://genetics.bwh.harvard.edu/cgi-bin/ggi/ggi2.cgi'
 result_url = 'http://genetics.bwh.harvard.edu'
 
-refresh_interval = 30
-TIMEOUT = 60 * 60
-TIME_DELAY = 7
-MAX_TRIES = 30
+TIMEOUT = 60 * 60 * 24
+TIME_DELAY = 30
+MAX_TRIES = 900000000
 
 # Genome assembly version used for chromosome
 # coordinates of the SNPs in user input
--- a/polyphen2_web/polyphen2_web.xml	Mon Apr 14 17:50:33 2014 -0400
+++ b/polyphen2_web/polyphen2_web.xml	Tue Oct 07 18:56:07 2014 -0400
@@ -55,6 +55,18 @@
             <output name="short_file" file="polyphen2_short.txt"/>
             <output name="snp_file" file="polyphen2_snp.txt"/>
         </test>
+        <test>
+            <param name="input" value="polyphen_input.txt"/>
+            <param name="ucscdb" value="hg19"/>
+            <param name="model" value="HumDiv"/>
+            <param name="filter" value="All"/>
+            <param name="function" value="All"/>
+            <output name="log_file" file="polyphen_output_log.tsv"/>
+            <output name="full_file" file="polyphen_output_full.tsv"/>
+            <output name="short_file" file="polyphen_output_short.tsv"/>
+            <output name="snp_file" file="polyphen_output_snp.tsv"/>
+        </test>
+
     </tests>
     <help>
         **What it does**
--- a/polyphen2_web/test-data/chasm_input.txt	Mon Apr 14 17:50:33 2014 -0400
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,5 +0,0 @@
-TR1 chr22 30421786 + A T
-TR2 chr22 29446079 + A G
-TR3 chr22 29446079 + A G
-TR4 chr22 40814500 - A G
-TR5 chr22 40815256 + C T
--- a/polyphen2_web/test-data/ma_nucleotide_output.csv	Mon Apr 14 17:50:33 2014 -0400
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,4 +0,0 @@
-"","Mutation","AA variant","Gene","MSA","PDB","Func. Impact","FI score","Uniprot","Refseq","MSA height","Codon start position","Func. region","Protein bind.site","DNA/RNA bind.site","small.mol bind.site"
-"1","hg19,13,32912555,G,T","D1355Y","BRCA2","http://getma.org/?cm=msa&ty=f&p=BRCA2_HUMAN&rb=1247&re=1420&var=D1355Y","","low","1.24","BRCA2_HUMAN","NP_000050","14","chr13:32912555","","","",""
-"2","hg19,7,55178574,G,A","","","","","","","","","0","","","","",""
-"3","hg19,7,55178574,G,A","","","","","","","","","0","","","","",""
--- a/polyphen2_web/test-data/ma_proper_nucleotide.csv	Mon Apr 14 17:50:33 2014 -0400
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,3 +0,0 @@
-13,32912555,G,T   BRCA2
-7,55178574,G,A   GBM
-7,55178574,G,A   GBM
--- a/polyphen2_web/test-data/ma_proper_protein.csv	Mon Apr 14 17:50:33 2014 -0400
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,6 +0,0 @@
-EGFR_HUMAN,R521K
-EGFR_HUMAN,R98Q,Polymorphism
-EGFR_HUMAN,G719D,disease
-NP_000537,G356A
-NP_000537,G360A,dbSNP:rs35993958
-NP_000537,S46A,Abolishes,phosphorylation
--- a/polyphen2_web/test-data/ma_proper_protein.tsv	Mon Apr 14 17:50:33 2014 -0400
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,6 +0,0 @@
-EGFR_HUMAN R521K 
-EGFR_HUMAN R98Q Polymorphism 
-EGFR_HUMAN G719D disease 
-NP_000537 G356A 
-NP_000537 G360A dbSNP:rs35993958 
-NP_000537 S46A Abolishes phosphorylation 
--- a/polyphen2_web/test-data/ma_protein_output.csv	Mon Apr 14 17:50:33 2014 -0400
+++ /dev/null	Thu Jan 01 00:00:00 1970 +0000
@@ -1,7 +0,0 @@
-"","Mutation","AA variant","Gene","MSA","PDB","Func. Impact","FI score","Uniprot","Refseq","MSA height","Codon start position","Func. region","Protein bind.site","DNA/RNA bind.site","small.mol bind.site"
-"1","EGFR_HUMAN R521K","R521K","EGFR","http://getma.org/?cm=msa&ty=f&p=EGFR_HUMAN&rb=482&re=681&var=R521K","http://getma.org/pdb.php?prot=EGFR_HUMAN&from=482&to=681&var=R521K","neutral","0.405","EGFR_HUMAN","NP_005219","399","chr7:55196748","1","1","",""
-"2","EGFR_HUMAN R98Q","R98Q","EGFR","http://getma.org/?cm=msa&ty=f&p=EGFR_HUMAN&rb=57&re=168&var=R98Q","http://getma.org/pdb.php?prot=EGFR_HUMAN&from=57&to=168&var=R98Q","neutral","0.6","EGFR_HUMAN","NP_005219","181","chr7:55178543","","","",""
-"3","EGFR_HUMAN G719D","G719D","EGFR","http://getma.org/?cm=msa&ty=f&p=EGFR_HUMAN&rb=712&re=968&var=G719D","http://getma.org/pdb.php?prot=EGFR_HUMAN&from=712&to=968&var=G719D","medium","3.115","EGFR_HUMAN","NP_005219","700","chr7:55209201","1","1","","0UN IRE FMM ANP CY7 HYZ 03P ITI DKI 685 T95 T74 ZZY M97 6XP 0K0 KRW 0JJ 0K1 P17 112 1N1 JIN STI P5C 585 S19 P16 VX6 P3Y SX7 ACK B90 AMP ZD6 STU 7PY BI9 BII ATP ADP 4ST VG8 YAM P1E 7X4 7X5 7X6 7X8 349 3JZ"
-"4","NP_000537 G356A","G356A","TP53","http://getma.org/?cm=msa&ty=f&p=P53_HUMAN&rb=318&re=359&var=G356A","http://getma.org/pdb.php?prot=P53_HUMAN&from=318&to=359&var=G356A","neutral","-0.895","P53_HUMAN","NP_000537","45","chr17:7514684","","1","",""
-"5","NP_000537 G360A","G360A","TP53","http://getma.org/?cm=msa&ty=f&p=P53_HUMAN&rb=360&re=393&var=G360A","","medium","2.25","P53_HUMAN","NP_000537","15","chr17:7514672","","","",""
-"6","NP_000537 S46A","S46A","TP53","http://getma.org/?cm=msa&ty=f&p=P53_HUMAN&rb=30&re=94&var=S46A","http://getma.org/pdb.php?prot=P53_HUMAN&from=30&to=94&var=S46A","neutral","0.55","P53_HUMAN","NP_000537","5","chr17:7520274","1","1","",""
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/polyphen2_web/test-data/polyphen_input.txt	Tue Oct 07 18:56:07 2014 -0400
@@ -0,0 +1,7 @@
+Q92889 706 I T
+Q92889 875 E G
+XRCC1_HUMAN 399 R Q
+NP_005792 59 L P
+rs1799931
+chr1:1267483 G/A
+chr1:1158631 A/C,G,T
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/polyphen2_web/test-data/polyphen_output_full.tsv	Tue Oct 07 18:56:07 2014 -0400
@@ -0,0 +1,20 @@
+#o_acc               	 o_pos	o_aa1	o_aa2	rsid      	acc       	   pos	aa1	aa2	nt1	nt2	        prediction	            based_on	    effect	        pph2_class	 pph2_prob	  pph2_FPR	  pph2_TPR	  pph2_FDR	    site	  region	    PHAT	dScore	Score1	Score2	MSAv	  Nobs	 Nstruct	 Nfilt	PDB_id	PDB_pos	PDB_ch	 ident	length	NormASA	SecStr	MapReg	  dVol	 dProp	B-fact	 H-bonds	 AveNHet	 MinDHet	 AveNInt	 MinDInt	 AveNSit	 MinDSit	Transv	CodPos	CpG	 MinDJxn	     PfamHit	  IdPmax	  IdPSNP	  IdQmin
+Q92889              	   706	    I	    T	rs1800069 	Q92889    	   706	  I	  T	  T	  C	 probably damaging	           alignment	         ?	       deleterious	         1	   0.00026	   0.00018	    0.0109	      NO	      NO	       ?	+2.055	-1.216	-3.271	   2	    52	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     0	     1	  0	    -100	  PF02732.10	   0.730	       ?	   14.63
+Q92889              	   875	    E	    G	rs1800124 	Q92889    	   875	  E	  G	  A	  G	 possibly damaging	           alignment	         ?	       deleterious	     0.937	    0.0566	     0.801	    0.0874	      NO	      NO	       ?	+1.645	-1.600	-3.245	   2	    51	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     0	     1	  0	    -607	          NO	   3.009	       ?	   63.97
+XRCC1_HUMAN         	   399	    R	    Q	rs25487   	P18887    	   399	  R	  Q	  G	  A	 probably damaging	           alignment	         ?	       deleterious	     0.979	    0.0411	     0.755	    0.0687	      NO	      NO	       ?	+1.579	-1.999	-3.578	   2	    86	      20	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     0	     1	  1	      +4	          NO	   2.498	       ?	   46.92
+NP_005792           	    59	    L	    P	rs3390    	P41567    	    59	  L	  P	  T	  C	 possibly damaging	           structure	     1.1.1	       deleterious	     0.895	    0.0631	      0.82	    0.0945	      NO	      NO	       ?	+1.235	-1.254	-2.489	   2	   104	       4	     1	  2if1	     72	     A	  1.00	   113	  0.007	     H	     A	   -55	  1.07	  0.00	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     0	     1	  0	     +20	  PF01253.17	  45.533	  45.533	   92.04
+rs1799931           	     ?	    ?	    ?	rs1799931 	P11245    	   286	  G	  E	  G	  A	            benign	           alignment	         ?	           neutral	     0.317	     0.112	     0.903	     0.144	      NO	      NO	       ?	+1.145	-2.309	-3.454	   2	    59	      20	     2	  2pfr	    286	     A	  1.00	   289	  0.172	     S	     l	    78	  0.75	 -0.03	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     0	     1	  0	    -863	          NO	   8.156	       ?	   82.41
+Q7RTX0              	   191	    R	    H	         ?	Q7RTX0    	   191	  R	  H	  G	  A	 probably damaging	           alignment	         ?	       deleterious	     0.998	    0.0112	     0.273	    0.0274	      NO	      NO	       ?	+2.547	-1.839	-4.386	   2	    57	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     0	     1	  1	    -164	  PF01094.23	   2.232	       ?	   72.89	# chr1:1267483|GA|uc010nyk.1+|TAS1R3|NP_689414
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	  T	  G	 possibly damaging	           alignment	         ?	           neutral	     0.454	    0.0996	     0.889	     0.132	      NO	      NO	       ?	+0.793	-1.779	-2.572	   2	    87	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	      +8	          NO	   7.550	   7.550	   41.99	# chr1:1158631|AC|uc001adh.3-|SDF4|NP_057260
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	  T	  A	 possibly damaging	           alignment	         ?	           neutral	     0.454	    0.0996	     0.889	     0.132	      NO	      NO	       ?	+0.793	-1.779	-2.572	   2	    87	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	      +8	          NO	   7.550	   7.550	   41.99	# chr1:1158631|AT|uc001adh.3-|SDF4|NP_057260
+Q9BRK5-6            	   190	    D	    E	         ?	Q9BRK5-6  	   190	  D	  E	  T	  G	 probably damaging	           alignment	         ?	       deleterious	     0.998	    0.0112	     0.273	    0.0274	       ?	       ?	       ?	+1.566	-1.300	-2.866	   2	    46	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	      +8	           ?	   2.573	       ?	   36.21	# chr1:1158631|AC|uc001adi.3-|SDF4|NP_057631
+Q9BRK5-6            	   190	    D	    E	         ?	Q9BRK5-6  	   190	  D	  E	  T	  A	 probably damaging	           alignment	         ?	       deleterious	     0.998	    0.0112	     0.273	    0.0274	       ?	       ?	       ?	+1.566	-1.300	-2.866	   2	    46	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	      +8	           ?	   2.573	       ?	   36.21	# chr1:1158631|AT|uc001adi.3-|SDF4|NP_057631
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	  T	  G	 possibly damaging	           alignment	         ?	           neutral	     0.454	    0.0996	     0.889	     0.132	      NO	      NO	       ?	+0.793	-1.779	-2.572	   2	    87	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	    -580	          NO	   7.550	   7.550	   41.99	# chr1:1158631|AC|uc001adj.1-|SDF4|
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	  T	  A	 possibly damaging	           alignment	         ?	           neutral	     0.454	    0.0996	     0.889	     0.132	      NO	      NO	       ?	+0.793	-1.779	-2.572	   2	    87	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	    -580	          NO	   7.550	   7.550	   41.99	# chr1:1158631|AT|uc001adj.1-|SDF4|
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	  T	  G	 possibly damaging	           alignment	         ?	           neutral	     0.454	    0.0996	     0.889	     0.132	      NO	      NO	       ?	+0.793	-1.779	-2.572	   2	    87	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	      +8	          NO	   7.550	   7.550	   41.99	# chr1:1158631|AC|uc009vjv.2-|SDF4|NP_057260
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	  T	  A	 possibly damaging	           alignment	         ?	           neutral	     0.454	    0.0996	     0.889	     0.132	      NO	      NO	       ?	+0.793	-1.779	-2.572	   2	    87	       ?	     ?	     ?	      ?	     ?	     ?	     ?	      ?	     ?	     ?	     ?	     ?	     ?	       ?	       ?	       ?	       ?	       ?	       ?	       ?	     1	     2	  0	      +8	          NO	   7.550	   7.550	   41.99	# chr1:1158631|AT|uc009vjv.2-|SDF4|NP_057260
+## Sources:
+##   Predictions: PolyPhen-2 v2.2.2r398
+##   Sequences:   UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011)
+##   Structures:  PDB/DSSP Snapshot 03-Jan-2012 (78304 Structures)
+##   Genes:       UCSC MultiZ46Way GRCh37/hg19 (08-Oct-2009)
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/polyphen2_web/test-data/polyphen_output_log.tsv	Tue Oct 07 18:56:07 2014 -0400
@@ -0,0 +1,36 @@
+===========================
+Stage 1/7: Validating input
+===========================
+No errors
+
+===============================
+Stage 2/7: Mapping genomic SNPs
+===============================
+No errors
+
+============================
+Stage 3/7: Collecting output
+============================
+No errors
+
+===============================================
+Stage 4/7: Building MSA and annotating proteins
+===============================================
+(XRCC1_HUMAN:399:R/Q)    WARNING: find_gene: Swapped codons (CAG>CGG) in uc002owt.2 nucleotide sequence at position: 1195
+(XRCC1_HUMAN:399:R/Q)    WARNING: Replaced reference AA residue (Q) with (R) in uc002owt.2 protein sequence at position: 399
+Total errors/warnings: 2
+
+============================
+Stage 5/7: Collecting output
+============================
+No errors
+
+=====================
+Stage 6/7: Predicting
+=====================
+No errors
+
+=============================
+Stage 7/7: Generating reports
+=============================
+No errors
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/polyphen2_web/test-data/polyphen_output_short.tsv	Tue Oct 07 18:56:07 2014 -0400
@@ -0,0 +1,20 @@
+#o_acc               	 o_pos	o_aa1	o_aa2	rsid      	acc       	   pos	aa1	aa2	        prediction	 pph2_prob	  pph2_FPR	  pph2_TPR
+Q92889              	   706	    I	    T	rs1800069 	Q92889    	   706	  I	  T	 probably damaging	         1	   0.00026	   0.00018
+Q92889              	   875	    E	    G	rs1800124 	Q92889    	   875	  E	  G	 possibly damaging	     0.937	    0.0566	     0.801
+XRCC1_HUMAN         	   399	    R	    Q	rs25487   	P18887    	   399	  R	  Q	 probably damaging	     0.979	    0.0411	     0.755
+NP_005792           	    59	    L	    P	rs3390    	P41567    	    59	  L	  P	 possibly damaging	     0.895	    0.0631	      0.82
+rs1799931           	     ?	    ?	    ?	rs1799931 	P11245    	   286	  G	  E	            benign	     0.317	     0.112	     0.903
+Q7RTX0              	   191	    R	    H	         ?	Q7RTX0    	   191	  R	  H	 probably damaging	     0.998	    0.0112	     0.273	# chr1:1267483|GA|uc010nyk.1+|TAS1R3|NP_689414
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	 possibly damaging	     0.454	    0.0996	     0.889	# chr1:1158631|AC|uc001adh.3-|SDF4|NP_057260
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	 possibly damaging	     0.454	    0.0996	     0.889	# chr1:1158631|AT|uc001adh.3-|SDF4|NP_057260
+Q9BRK5-6            	   190	    D	    E	         ?	Q9BRK5-6  	   190	  D	  E	 probably damaging	     0.998	    0.0112	     0.273	# chr1:1158631|AC|uc001adi.3-|SDF4|NP_057631
+Q9BRK5-6            	   190	    D	    E	         ?	Q9BRK5-6  	   190	  D	  E	 probably damaging	     0.998	    0.0112	     0.273	# chr1:1158631|AT|uc001adi.3-|SDF4|NP_057631
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	 possibly damaging	     0.454	    0.0996	     0.889	# chr1:1158631|AC|uc001adj.1-|SDF4|
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	 possibly damaging	     0.454	    0.0996	     0.889	# chr1:1158631|AT|uc001adj.1-|SDF4|
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	 possibly damaging	     0.454	    0.0996	     0.889	# chr1:1158631|AC|uc009vjv.2-|SDF4|NP_057260
+Q9BRK5              	   190	    D	    E	         ?	Q9BRK5    	   190	  D	  E	 possibly damaging	     0.454	    0.0996	     0.889	# chr1:1158631|AT|uc009vjv.2-|SDF4|NP_057260
+## Sources:
+##   Predictions: PolyPhen-2 v2.2.2r398
+##   Sequences:   UniProtKB/UniRef100 Release 2011_12 (14-Dec-2011)
+##   Structures:  PDB/DSSP Snapshot 03-Jan-2012 (78304 Structures)
+##   Genes:       UCSC MultiZ46Way GRCh37/hg19 (08-Oct-2009)
--- /dev/null	Thu Jan 01 00:00:00 1970 +0000
+++ b/polyphen2_web/test-data/polyphen_output_snp.tsv	Tue Oct 07 18:56:07 2014 -0400
@@ -0,0 +1,24 @@
+#snp_pos         	str	        gene	  transcript	 ccid	        ccds	cciden	refa	        type	   ntpos	nt1	nt2	flanks	trv	cpg	  jxdon	  jxacc	   exon	  cexon	jxc	dgn	  cdnpos	frame	cdn1	cdn2	aa1	aa2	   aapos	spmap	     spacc	      spname	    refs_acc	    dbrsid	dbobsrvd	   dbavHet	 dbavHetSE	dbRmPaPt	comments
+chr1:1267483    	  +	      TAS1R3	  uc010nyk.1	   59	 CCDS30556.1	 0.999	 G/A	    missense	     758	  G	  A	    CT	  0	  1	   -164	    -80	    3/6	    3/6	  ?	  0	     191	    1	 CGT	 CAT	  R	  H	     191	    1	    Q7RTX0	 TS1R3_HUMAN	   NP_689414	rs141717515	     A/G	   0.00063	  0.017742	   G>G>G
+chr1:1158631    	  -	        SDF4	  uc001adh.3	   49	 CCDS30553.1	     1	 A/C	    missense	    8817	  T	  G	    AG	  1	  0	     +8	   -107	    4/7	    3/6	  ?	  2	     190	    2	 GAT	 GAG	  D	  E	     190	    1	    Q9BRK5	 CAB45_HUMAN	   NP_057260	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc001adh.3	   49	 CCDS30553.1	     1	 A/G	coding-synon	    8817	  T	  C	    AG	  0	  2	     +8	   -107	    4/7	    3/6	  ?	  2	     190	    2	 GAT	 GAC	  D	  D	     190	    1	    Q9BRK5	 CAB45_HUMAN	   NP_057260	 rs6603781	     T/C	  0.133948	  0.221431	   T>C>C
+chr1:1158631    	  -	        SDF4	  uc001adh.3	   49	 CCDS30553.1	     1	 A/T	    missense	    8817	  T	  A	    AG	  1	  0	     +8	   -107	    4/7	    3/6	  ?	  2	     190	    2	 GAT	 GAA	  D	  E	     190	    1	    Q9BRK5	 CAB45_HUMAN	   NP_057260	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc001adi.3	    ?	    CCDS12.1	     1	 A/C	    missense	    8817	  T	  G	    AG	  1	  0	     +8	   -107	    4/7	    3/6	  ?	  2	     190	    2	 GAT	 GAG	  D	  E	     190	    1	  Q9BRK5-6	 CAB45_HUMAN	   NP_057631	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc001adi.3	    ?	    CCDS12.1	     1	 A/G	coding-synon	    8817	  T	  C	    AG	  0	  2	     +8	   -107	    4/7	    3/6	  ?	  2	     190	    2	 GAT	 GAC	  D	  D	     190	    1	  Q9BRK5-6	 CAB45_HUMAN	   NP_057631	 rs6603781	     T/C	  0.133948	  0.221431	   T>C>C
+chr1:1158631    	  -	        SDF4	  uc001adi.3	    ?	    CCDS12.1	     1	 A/T	    missense	    8817	  T	  A	    AG	  1	  0	     +8	   -107	    4/7	    3/6	  ?	  2	     190	    2	 GAT	 GAA	  D	  E	     190	    1	  Q9BRK5-6	 CAB45_HUMAN	   NP_057631	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc001adj.1	    ?	           ?	     ?	 A/C	    missense	     718	  T	  G	    AG	  1	  0	   -580	   -107	    2/2	    2/2	  ?	  2	      68	    2	 GAT	 GAG	  D	  E	     190	    1	    Q9BRK5	 CAB45_HUMAN	           ?	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc001adj.1	    ?	           ?	     ?	 A/G	coding-synon	     718	  T	  C	    AG	  0	  2	   -580	   -107	    2/2	    2/2	  ?	  2	      68	    2	 GAT	 GAC	  D	  D	     190	    1	    Q9BRK5	 CAB45_HUMAN	           ?	 rs6603781	     T/C	  0.133948	  0.221431	   T>C>C
+chr1:1158631    	  -	        SDF4	  uc001adj.1	    ?	           ?	     ?	 A/T	    missense	     718	  T	  A	    AG	  1	  0	   -580	   -107	    2/2	    2/2	  ?	  2	      68	    2	 GAT	 GAA	  D	  E	     190	    1	    Q9BRK5	 CAB45_HUMAN	           ?	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc009vjv.2	    ?	           ?	     ?	 A/C	    missense	    8817	  T	  G	    AG	  1	  0	     +8	   -107	    3/6	    2/5	  ?	  2	      68	    2	 GAT	 GAG	  D	  E	     190	    1	    Q9BRK5	 CAB45_HUMAN	   NP_057260	         ?	       ?	         ?	         ?	       ?
+chr1:1158631    	  -	        SDF4	  uc009vjv.2	    ?	           ?	     ?	 A/G	coding-synon	    8817	  T	  C	    AG	  0	  2	     +8	   -107	    3/6	    2/5	  ?	  2	      68	    2	 GAT	 GAC	  D	  D	     190	    1	    Q9BRK5	 CAB45_HUMAN	   NP_057260	 rs6603781	     T/C	  0.133948	  0.221431	   T>C>C
+chr1:1158631    	  -	        SDF4	  uc009vjv.2	    ?	           ?	     ?	 A/T	    missense	    8817	  T	  A	    AG	  1	  0	     +8	   -107	    3/6	    2/5	  ?	  2	      68	    2	 GAT	 GAA	  D	  E	     190	    1	    Q9BRK5	 CAB45_HUMAN	   NP_057260	         ?	       ?	         ?	         ?	       ?
+## Totals:
+##   lines input               2
+##   lines skipped             0
+##   alleles annotated        13
+##     missense                9
+##     nonsense                0
+##     coding-synon            4
+##     intron                  0
+##     utr-3                   0
+##     utr-5                   0
--- a/polyphen2_web/tool_dependencies.xml	Mon Apr 14 17:50:33 2014 -0400
+++ b/polyphen2_web/tool_dependencies.xml	Tue Oct 07 18:56:07 2014 -0400
@@ -1,6 +1,6 @@
 <?xml version="1.0"?>
 <tool_dependency>
     <package name="beautifulsoup4" version="4.1.0">
-        <repository changeset_revision="829eeedb1083" name="package_beautifulsoup4_4_1_0" owner="saketkc" toolshed="http://testtoolshed.g2.bx.psu.edu" />
+        <repository changeset_revision="df0beb7ea718" name="package_beautifulsoup4_4_1_0" owner="saketkc" toolshed="http://testtoolshed.g2.bx.psu.edu" />
     </package>
 </tool_dependency>