Mercurial > repos > rhpvorderman > shm_csr

annotate shm_overview.htm @ 5:495a521cf9f2 draft

Find changesets by keywords (author, files, the commit message), revision number or hash, or revset expression.
"planemo upload commit 40d62ec3d2fea3c3bac605c976941e1f3b7e2cd4"
author rhpvorderman
date Tue, 16 Nov 2021 11:16:06 +0000
parents c8f02bce10d0
children
Ignore whitespace changes - Everywhere: Within whitespace: At end of lines:
rev   line source
0
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
1 <html>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
2
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
3 <head>
5
495a521cf9f2 "planemo upload commit 40d62ec3d2fea3c3bac605c976941e1f3b7e2cd4"
rhpvorderman
parents: 4
diff changeset
4 <meta http-equiv=Content-Type content="text/html; charset=UTF-8">
0
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
5 <meta name=Generator content="Microsoft Word 14 (filtered)">
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
6 <style>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
7 <!--
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
8 /* Font Definitions */
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
9 @font-face
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
10 {font-family:Calibri;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
11 panose-1:2 15 5 2 2 2 4 3 2 4;}
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
12 /* Style Definitions */
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
13 p.MsoNormal, li.MsoNormal, div.MsoNormal
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
14 {margin-top:0in;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
15 margin-right:0in;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
16 margin-bottom:10.0pt;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
17 margin-left:0in;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
18 line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
19 font-size:11.0pt;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
20 font-family:"Calibri","sans-serif";}
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
21 .MsoChpDefault
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
22 {font-family:"Calibri","sans-serif";}
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
23 .MsoPapDefault
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
24 {margin-bottom:10.0pt;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
25 line-height:115%;}
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
26 @page WordSection1
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
27 {size:8.5in 11.0in;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
28 margin:1.0in 1.0in 1.0in 1.0in;}
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
29 div.WordSection1
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
30 {page:WordSection1;}
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
31 -->
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
32 </style>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
33
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
34 </head>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
35
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
36 <body lang=EN-US>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
37
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
38 <div class=WordSection1>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
39
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
40 <p class=MsoNormalCxSpFirst style='text-align:justify'><b><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
41 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Info
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
42 table</span></b></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
43
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
44 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
45 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>This
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
46 table contains information on different characteristics of SHM. For all
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
47 characteristics information can be found for all sequences or only sequences of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
48 a certain (sub)class. All results are based on the sequences that passed the filter
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
49 settings chosen on the start page of the SHM &amp; CSR pipeline and only
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
50 include details on the analysed region as determined by the setting of the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
51 sequence starts at filter. All data in this table can be downloaded via the
4
c8f02bce10d0 "planemo upload commit 05326cc2233eb0fa8beaf4198bd7c1519f2a0bf9"
rhpvorderman
parents: 0
diff changeset
52 “downloads” tab.</span></p>
0
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
53
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
54 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
55 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Mutation
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
56 frequency:</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
57
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
58 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK83"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
59 name="OLE_LINK82"></a><a name="OLE_LINK81"><span lang=EN-GB style='font-size:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
60 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These values
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
61 give information on the level of SHM. </span></a><a name="OLE_LINK22"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
62 name="OLE_LINK21"></a><a name="OLE_LINK20"><span lang=EN-GB style='font-size:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
63 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>More information
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
64 on the values found in healthy individuals of different ages can be found in </span></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
65 name="OLE_LINK15"></a><a name="OLE_LINK14"></a><a name="OLE_LINK13"><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
66 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>IJspeert
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
67 and van Schouwenburg et al, PMID: 27799928</span></a></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
68
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
69 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
70 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Number
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
71 of mutations:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
72 115%;font-family:"Times New Roman","serif"'> Shows the number of total
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
73 mutations / the number of sequenced bases (the % of mutated bases).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
74
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
75 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
76 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Median
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
77 number of mutations:</span></i><span lang=EN-GB style='font-size:12.0pt;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
78 line-height:115%;font-family:"Times New Roman","serif"'> Shows the median % of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
79 SHM of all sequences.</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
80
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
81 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
82 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Patterns
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
83 of SHM:</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
84
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
85 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK72"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
86 name="OLE_LINK71"></a><a name="OLE_LINK70"><span lang=EN-GB style='font-size:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
87 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These values
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
88 give insights into the targeting and patterns of SHM. These values can give
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
89 insight into the repair pathways used to repair the U:G mismatches introduced
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
90 by AID. </span></a><a name="OLE_LINK40"></a><a name="OLE_LINK39"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
91 name="OLE_LINK38"></a><a name="OLE_LINK60"><span lang=EN-GB style='font-size:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
92 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>More information
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
93 on the values found in healthy individuals of different ages can be found in
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
94 IJspeert and van Schouwenburg et al, PMID: 27799928</span></a></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
95
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
96 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
97 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transitions:</span></i><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
98 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
99 Shows the number of transition mutations / the number of total mutations (the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
100 percentage of mutations that are transitions). Transition mutations are C&gt;T,
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
101 T&gt;C, A&gt;G, G&gt;A. </span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
102
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
103 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
104 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transversions:</span></i><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
105 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
106 Shows the number of transversion mutations / the number of total mutations (the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
107 percentage of mutations that are transitions). Transversion mutations are
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
108 C&gt;A, C&gt;G, T&gt;A, T&gt;G, A&gt;T, A&gt;C, G&gt;T, G&gt;C.</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
109
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
110 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
111 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transitions
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
112 at GC:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
113 font-family:"Times New Roman","serif"'> <a name="OLE_LINK2"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
114 name="OLE_LINK1">Shows the number of transitions at GC locations (C&gt;T,
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
115 G&gt;A) / the total number of mutations at GC locations (the percentage of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
116 mutations at GC locations that are transitions).</a></span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
117
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
118 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
119 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Targeting
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
120 of GC:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
121 font-family:"Times New Roman","serif"'> <a name="OLE_LINK7"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
122 name="OLE_LINK6"></a><a name="OLE_LINK3">Shows the number of mutations at GC
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
123 locations / the total number of mutations (the percentage of total mutations
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
124 that are at GC locations).</a> </span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
125
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
126 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
127 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Transitions
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
128 at AT:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
129 font-family:"Times New Roman","serif"'> Shows the number of transitions at AT
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
130 locations (T&gt;C, A&gt;G) / the total number of mutations at AT locations (the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
131 percentage of mutations at AT locations that are transitions).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
132
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
133 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
134 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Targeting
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
135 of AT:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
136 font-family:"Times New Roman","serif"'> Shows the number of mutations at AT
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
137 locations / the total number of mutations (the percentage of total mutations
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
138 that are at AT locations).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
139
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
140 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
141 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>RGYW:</span></i><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
142 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
143 <a name="OLE_LINK28"></a><a name="OLE_LINK27"></a><a name="OLE_LINK26">Shows
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
144 the number of mutations that are in a RGYW motive / The number of total mutations
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
145 (the percentage of mutations that are in a RGYW motive). </a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
146 name="OLE_LINK62"></a><a name="OLE_LINK61">RGYW motives are known to be
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
147 preferentially targeted by AID </a></span><span lang=EN-GB style='font-size:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
148 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>(R=Purine,
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
149 Y=pyrimidine, W = A or T).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
150
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
151 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
152 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>WRCY:</span></i><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
153 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
154 <a name="OLE_LINK34"></a><a name="OLE_LINK33">Shows the number of mutations
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
155 that are in a </a><a name="OLE_LINK32"></a><a name="OLE_LINK31"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
156 name="OLE_LINK30"></a><a name="OLE_LINK29">WRCY</a> motive / The number of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
157 total mutations (the percentage of mutations that are in a WRCY motive). WRCY
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
158 motives are known to be preferentially targeted by AID </span><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
159 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>(R=Purine,
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
160 Y=pyrimidine, W = A or T).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
161
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
162 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
163 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>WA:</span></i><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
164 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
165 <a name="OLE_LINK37"></a><a name="OLE_LINK36"></a><a name="OLE_LINK35">Shows
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
166 the number of mutations that are in a WA motive / The number of total mutations
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
167 (the percentage of mutations that are in a WA motive). It is described that
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
168 polymerase eta preferentially makes errors at WA motives </a></span><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
169 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>(W
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
170 = A or T).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
171
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
172 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
173 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>TW:</span></i><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
174 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
175 Shows the number of mutations that are in a TW motive / The number of total mutations
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
176 (the percentage of mutations that are in a TW motive). It is described that
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
177 polymerase eta preferentially makes errors at TW motives </span><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
178 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>(W
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
179 = A or T).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
180
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
181 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
182 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Antigen
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
183 selection:</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
184
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
185 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
186 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
187 values give insight into antigen selection. It has been described that during
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
188 antigen selection, there is selection against replacement mutations in the FR
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
189 regions as these can cause instability of the B-cell receptor. In contrast
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
190 replacement mutations in the CDR regions are important for changing the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
191 affinity of the B-cell receptor and therefore there is selection for this type
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
192 of mutations. Silent mutations do not alter the amino acid sequence and
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
193 therefore do not play a role in selection. More information on the values found
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
194 in healthy individuals of different ages can be found in IJspeert and van
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
195 Schouwenburg et al, PMID: 27799928</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
196
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
197 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
198 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>FR
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
199 R/S:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
200 font-family:"Times New Roman","serif"'> <a name="OLE_LINK43"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
201 name="OLE_LINK42"></a><a name="OLE_LINK41">Shows the number of replacement
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
202 mutations in the FR regions / The number of silent mutations in the FR regions
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
203 (the number of replacement mutations in the FR regions divided by the number of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
204 silent mutations in the FR regions)</a></span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
205
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
206 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
207 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>CDR
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
208 R/S:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
209 font-family:"Times New Roman","serif"'> Shows the number of replacement
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
210 mutations in the CDR regions / The number of silent mutations in the CDR
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
211 regions (the number of replacement mutations in the CDR regions divided by the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
212 number of silent mutations in the CDR regions)</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
213
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
214 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
215 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Number
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
216 of sequences nucleotides:</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
217
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
218 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
219 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
220 values give information on the number of sequenced nucleotides.</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
221
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
222 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
223 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Nt
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
224 in FR:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
225 font-family:"Times New Roman","serif"'> <a name="OLE_LINK46"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
226 name="OLE_LINK45"></a><a name="OLE_LINK44">Shows the number of sequences bases
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
227 that are located in the FR regions / The total number of sequenced bases (the
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
228 percentage of sequenced bases that are present in the FR regions).</a></span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
229
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
230 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
231 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Nt
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
232 in CDR:</span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
233 font-family:"Times New Roman","serif"'> Shows the number of sequenced bases
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
234 that are located in the CDR regions / <a name="OLE_LINK48"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
235 name="OLE_LINK47">The total number of sequenced bases (the percentage of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
236 sequenced bases that are present in the CDR regions).</a></span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
237
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
238 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
239 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>A:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
240 </span></i><a name="OLE_LINK51"></a><a name="OLE_LINK50"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
241 name="OLE_LINK49"><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
242 font-family:"Times New Roman","serif"'>Shows the total number of sequenced
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
243 adenines / The total number of sequenced bases (the percentage of sequenced
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
244 bases that were adenines).</span></a></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
245
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
246 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
247 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>C:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
248 </span></i><a name="OLE_LINK53"></a><a name="OLE_LINK52"><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
249 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Shows
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
250 the total number of sequenced cytosines / The total number of sequenced bases
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
251 (the percentage of sequenced bases that were cytosines).</span></a></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
252
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
253 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
254 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>T:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
255 </span></i><a name="OLE_LINK57"></a><a name="OLE_LINK56"><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
256 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Shows
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
257 the total number of sequenced </span></a><a name="OLE_LINK55"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
258 name="OLE_LINK54"><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
259 font-family:"Times New Roman","serif"'>thymines</span></a><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
260 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
261 / The total number of sequenced bases (the percentage of sequenced bases that
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
262 were thymines).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
263
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
264 <p class=MsoNormalCxSpMiddle style='text-align:justify'><i><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
265 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>G:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
266 </span></i><span lang=EN-GB style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
267 font-family:"Times New Roman","serif"'>Shows the total number of sequenced <a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
268 name="OLE_LINK59"></a><a name="OLE_LINK58">guanine</a>s / The total number of
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
269 sequenced bases (the percentage of sequenced bases that were guanines).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
270
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
271 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK69"><b><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
272 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Graphs</span></b></a></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
273
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
274 <p class=MsoNormalCxSpMiddle style='text-align:justify'><a name="OLE_LINK75"></a><a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
275 name="OLE_LINK74"></a><a name="OLE_LINK73"><span lang=EN-GB style='font-size:
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
276 12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>These graphs visualize
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
277 information on the patterns and targeting of SHM and thereby give information
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
278 into the repair pathways used to repair the U:G mismatches introduced by AID. The
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
279 data represented in these graphs can be downloaded in the download tab. More
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
280 information on the values found in healthy individuals of different ages can be
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
281 found in IJspeert and van Schouwenburg et al, PMID: 27799928</span></a><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
282 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>.
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
283 <a name="OLE_LINK85"></a><a name="OLE_LINK84"></a></span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
284
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
285 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
286 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Percentage
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
287 of mutations in AID and pol eta motives</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
288
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
289 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
290 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Visualizes
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
291 <a name="OLE_LINK80"></a><a name="OLE_LINK79"></a><a name="OLE_LINK78">for each
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
292 (sub)class </a>the percentage of mutations that are present in AID (RGYW or
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
293 WRCY) or polymerase eta motives (WA or TW) in the different subclasses </span><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
294 lang=EN-GB style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>(R=Purine,
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
295 Y=pyrimidine, W = A or T).</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
296
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
297 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=NL
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
298 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Relative
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
299 mutation patterns</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
300
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
301 <p class=MsoNormalCxSpMiddle style='text-align:justify'><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
302 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Visualizes
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
303 for each (sub)class the distribution of mutations between mutations at AT
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
304 locations and transitions or transversions at GC locations. </span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
305
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
306 <p class=MsoNormalCxSpMiddle style='text-align:justify'><u><span lang=NL
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
307 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Absolute
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
308 mutation patterns</span></u></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
309
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
310 <p class=MsoNormalCxSpLast style='text-align:justify'><span lang=EN-GB
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
311 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Visualized
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
312 for each (sub)class the percentage of sequenced AT and GC bases that are
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
313 mutated. The mutations at GC bases are divided into transition and transversion
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
314 mutations<a name="OLE_LINK77"></a><a name="OLE_LINK76">. </a></span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
315
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
316 <p class=MsoNormal><span lang=NL style='font-size:12.0pt;line-height:115%;
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
317 font-family:"Times New Roman","serif"'>Hanna IJspeert, Pauline A. van
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
318 Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J. Driessen,
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
319 Andrew P. Stubbs, and Mirjam van der Burg (2016). </span><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
320 style='font-size:12.0pt;line-height:115%;font-family:"Times New Roman","serif"'>Evaluation
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
321 of the Antigen-Experienced B-Cell Receptor Repertoire in Healthy Children and
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
322 Adults. In <i>Frontiers in Immunolog, 7, pp. e410-410. </i>[<a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
323 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
324 style='color:windowtext'>doi:10.3389/fimmu.2016.00410</span></a>][<a
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
325 href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066086/"><span
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
326 style='color:windowtext'>Link</span></a>]</span></p>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
327
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
328 </div>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
329
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
330 </body>
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
331
64d74ba01a7c "planemo upload commit 78d1fae87dbcf490e49a9f99e7a06de7328e16d4"
rhpvorderman
parents:
diff changeset
332 </html>