Mercurial > repos > bgruening > chemfp
changeset 36:bcb3c078b2b4 draft
planemo upload for repository https://github.com/bgruening/galaxytools/tree/master/chemicaltoolbox/chemfp commit d786052cd04f8b25eb4aff80b1b9724f62031b61
| author | bgruening |
|---|---|
| date | Sat, 20 May 2017 12:56:09 -0400 |
| parents | a9fd0995b5bf |
| children | ea7557bd4635 |
| files | butina_clustering.py butina_clustering.xml mol2fps.xml nxn_clustering.py nxn_clustering.xml sdf2fps.xml simsearch.xml static/images/NxN_clustering.png static/images/NxN_clustering.svg test-data/CID_2244.can test-data/CID_2244.inchi test-data/CID_2244.sdf test-data/CID_2244.smi test-data/CID_2244_FP2.fps test-data/CID_2244_FP3.fps test-data/CID_2244_FP4.fps test-data/CID_2244_MACCS.fps test-data/CID_2244_maccs.fps test-data/NxN_Clustering_on_q.svg test-data/Taylor-Butina_Clustering_on_data_q.txt test-data/sdf2fps_result1.fps test-data/simsearch_on_tragets_and_q.tabular |
| diffstat | 22 files changed, 4004 insertions(+), 130 deletions(-) [+] |
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/butina_clustering.py Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,134 @@ +#!/usr/bin/env python +""" + Modified version of code examples from the chemfp project. + http://code.google.com/p/chem-fingerprints/ + Thanks to Andrew Dalke of Andrew Dalke Scientific! +""" + +import chemfp +import sys +import os +import tempfile +import argparse +import subprocess +from chemfp import search + +def unix_sort(results): + temp_unsorted = tempfile.NamedTemporaryFile(delete=False) + for (i,indices) in enumerate( results.iter_indices() ): + temp_unsorted.write('%s %s\n' % (len(indices), i)) + temp_unsorted.close() + temp_sorted = tempfile.NamedTemporaryFile(delete=False) + temp_sorted.close() + p = subprocess.Popen(['sort', '-n', '-r', '-k', '1,1'], stdin=open(temp_unsorted.name), stdout=open(temp_sorted.name, 'w+')) + stdout, stderr = p.communicate() + return_code = p.returncode + + if return_code: + sys.stdout.write(stdout) + sys.stderr.write(stderr) + sys.stderr.write("Return error code %i from command:\n" % return_code) + temp_sorted.close() + os.remove(temp_unsorted.name) + + for line in open(temp_sorted.name): + size, fp_idx = line.strip().split() + yield (int(size), int(fp_idx)) + + os.remove(temp_sorted.name) + +def butina( args ): + """ + Taylor-Butina clustering from the chemfp help. + """ + out = args.output_path + targets = chemfp.open( args.input_path, format='fps' ) + arena = chemfp.load_fingerprints( targets ) + + chemfp.set_num_threads( args.processors ) + results = search.threshold_tanimoto_search_symmetric(arena, threshold = args.tanimoto_threshold) + results.reorder_all("move-closest-first") + + sorted_ids = unix_sort(results) + + # Determine the true/false singletons and the clusters + true_singletons = [] + false_singletons = [] + clusters = [] + + seen = set() + #for (size, fp_idx, members) in results: + for (size, fp_idx) in sorted_ids: + members = results[fp_idx].get_indices() + #print arena.ids[ fp_idx ], [arena.ids[ m ] for m in members] + if fp_idx in seen: + # Can't use a centroid which is already assigned + continue + seen.add(fp_idx) + + if size == 0: + # The only fingerprint in the exclusion sphere is itself + true_singletons.append( fp_idx ) + continue + + # Figure out which ones haven't yet been assigned + unassigned = set(members) - seen + + if not unassigned: + false_singletons.append(fp_idx) + continue + + # this is a new cluster + clusters.append( (fp_idx, unassigned) ) + seen.update(unassigned) + + len_cluster = len(clusters) + #out.write( "#%s true singletons: %s\n" % ( len(true_singletons), " ".join(sorted(arena.ids[idx] for idx in true_singletons)) ) ) + #out.write( "#%s false singletons: %s\n" % ( len(false_singletons), " ".join(sorted(arena.ids[idx] for idx in false_singletons)) ) ) + + out.write( "#%s true singletons\n" % len(true_singletons) ) + out.write( "#%s false singletons\n" % len(false_singletons) ) + out.write( "#clusters: %s\n" % len_cluster ) + + # Sort so the cluster with the most compounds comes first, + # then by alphabetically smallest id + def cluster_sort_key(cluster): + centroid_idx, members = cluster + return -len(members), arena.ids[centroid_idx] + + clusters.sort(key=cluster_sort_key) + + for centroid_idx, members in clusters: + centroid_name = arena.ids[centroid_idx] + out.write("%s\t%s\t%s\n" % (centroid_name, len(members), " ".join(arena.ids[idx] for idx in members))) + #ToDo: len(members) need to be some biggest top 90% or something ... + + for idx in true_singletons: + out.write("%s\t%s\n" % (arena.ids[idx], 0)) + + out.close() + + +if __name__ == "__main__": + parser = argparse.ArgumentParser(description="""Taylor-Butina clustering for fps files. +For more details please see the original publication or the chemfp documentation: +http://www.chemomine.co.uk/dbclus-paper.pdf +https://chemfp.readthedocs.org +""") + + parser.add_argument("-i", "--input", dest="input_path", + required=True, + help="Path to the input file.") + + parser.add_argument("-o", "--output", dest="output_path", type=argparse.FileType('w'), + default=sys.stdout, + help="Path to the output file.") + + parser.add_argument("-t", "--threshold", dest="tanimoto_threshold", type=float, + default=0.8, + help="Tanimoto threshold [0.8]") + + parser.add_argument('-p', '--processors', type=int, default=4) + + options = parser.parse_args() + butina( options )
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/butina_clustering.xml Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,93 @@ +<tool id="ctb_chemfp_butina_clustering" name="Taylor-Butina Clustering" version="0.2"> + <description>of molecular fingerprints</description> + <requirements> + <requirement type="package" version="1.1p1">chemfp</requirement> + <requirement type="package" version="2.4.1">openbabel</requirement> + </requirements> + <command detect_errors="exit_code"> +<![CDATA[ + python '$__tool_directory__/butina_clustering.py' + -i '$infile' + -t $threshold + -o '$outfile' + -p \${GALAXY_SLOTS:-1} +]]> + </command> + <inputs> + <param name="infile" type="data" format="fps" label="Finperprint dataset" help="Dataset missing? See TIP below"/> + <param name='threshold' type='float' value='0.8'/> + </inputs> + <outputs> + <data format="tabular" name="outfile"/> + </outputs> + <tests> + <test> + <param name="infile" ftype="fps" value="targets.fps"/> + <param name='threshold' value='0.8' ></param> + <output name="outfile" ftype="tabular" file='Taylor-Butina_Clustering_on_data_q.txt'/> + </test> + </tests> +<help> +<![CDATA[ + + +.. class:: infomark + +**What this tool does** + +Unsupervised non-hierarchical clustering method based on the Taylor-Butina algorithm, which guarantees that every cluster contains molecules which are within a distance cutoff of the central molecule. This tool is based on the chemfp_ project. + +.. _chemfp: http://chemfp.com/ + +----- + +.. class:: infomark + +**Input** + +| Molecular fingerprints in FPS format. +| Open Babel Fastsearch index is not supported. + +* Example:: + + - fingerprints in FPS format + + #FPS1 + #num_bits=881 + #type=CACTVS-E_SCREEN/1.0 extended=2 + #software=CACTVS/unknown + #source=/home/mohammed/galaxy-central/database/files/000/dataset_423.dat + #date=2012-02-09T13:20:37 + 07ce04000000000000000000000000000080060000000c000000000000001a800f0000780008100000701487e960cc0bed3248000580644626004101b4844805901b041c2e + 19511e45039b8b2926101609401b13e40800000000000100200000040080000010000002000000000000 55169009 + 07ce04000000000000000000000000000080060000000c000000000000001a800f0000780008100000701087e960cc0bed3248000580644626004101b4844805901b041c2e + 19111e45039b8b2926105609401313e40800000000000100200000040080000010000002000000000000 55079807 + ........ + + - Tanimoto threshold : 0.8 (between 0 and 1) + +----- + +.. class:: infomark + +**Output** + +* Example:: + + 0 true singletons + => + + 0 false singletons + => + + 1 clusters + 55091849 has 12 other members + => 6499094 6485578 55079807 3153534 55102353 55091466 55091416 6485577 55169009 55091752 55091467 55168823 + + +]]> + </help> + <citations> + <citation type="doi">10.1186/1758-2946-5-S1-P36</citation> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/mol2fps.xml Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,276 @@ +<tool id="ctb_chemfp_mol2fps" name="Molecules to Fingerprints" version="0.3.0"> + <description>with different fingerprint types</description> + <!--parallelism method="multi" split_inputs="infile" split_mode="to_size" split_size="10000" merge_outputs="outfile"></parallelism--> + <requirements> + <requirement type="package" version="1.1p1">chemfp</requirement> + <requirement type="package" version="2016.03.3">rdkit</requirement> + <requirement type="package" version="2.4.1">openbabel</requirement> + </requirements> + <command> +<![CDATA[ + #set $fptype = $fp_opts.fp_opts_selector + + #if $fptype in ['--FP2', '--FP3', '--FP4', '--MACCS']: + ## Open Babel fingerprints + ob2fps $fptype --in '${infile.ext}' '${infile}' -o '${outfile}' + #else: + ## RDKit fingerprints + rdkit2fps --in '${infile.ext}' '${infile}' -o '${outfile}' + #if $fp_opts.fp_opts_selector == "--RDK": + --RDK + --fpSize $fp_opts.fpSize + --minPath $fp_opts.minPath + --maxPath $fp_opts.maxPath + --nBitsPerHash $fp_opts.nBitsPerHash + $fp_opts.useHs + #elif $fp_opts.fp_opts_selector == "--torsions": + --torsions + --fpSize $fp_opts.fpSize + --targetSize $fp_opts.targetSize + #elif $fp_opts.fp_opts_selector == "--morgan": + --morgan + --fpSize $fp_opts.fpSize + --radius $fp_opts.radius + $fp_opts.useFeatures + $fp_opts.useChirality + $fp_opts.useBondTypes + #elif $fp_opts.fp_opts_selector == "--pairs": + --paris + --fpSize $fp_opts.fpSize + --minLength $fp_opts.minLength + --maxLength $fp_opts.maxLength + #elif $fp_opts.fp_opts_selector == "--maccs166": + --maccs166 + #elif $fp_opts.fp_opts_selector == "--substruct": + --substruct + #end if + #end if + --errors report 2>&1 +]]> + </command> + <inputs> + <param name="infile" type='data' format="sdf,smi,mol,mol2,cml,inchi" label="molecule file"/> + <conditional name="fp_opts"> + <param name="fp_opts_selector" type="select" label="Type of fingerprint"> + <option value='--FP2' selected="True">Open Babel FP2 fingerprints</option> + <option value='--FP3'>Open Babel FP3 fingerprints</option> + <option value='--FP4'>Open Babel FP4 fingerprints</option> + <option value='--MACCS'>Open Babel MACCS fingerprints</option> + <option value='--RDK'>RDKit topological fingerprint</option> + <option value='--torsions'>RDKit topological Torsion fingerprints</option> + <option value='--morgan'>RDKit Morgan fingerprints</option> + <option value='--pairs'>RDKit Atom Pair fingerprints</option> + <option value='--maccs166'>RDKit MACCS fingerprints</option> + <option value='--substruct'>RDKit substructure fingerprints</option> + </param> + <when value="--FP2" /> + <when value="--FP3" /> + <when value="--FP4" /> + <when value="--MACCS" /> + <when value="--RDK"> + <param name="fpSize" type="integer" value="2048" label="number of bits in the fingerprint" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="minPath" type="integer" value="1" label="minimum number of bonds to include in the subgraph" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="maxPath" type="integer" value="7" label="maximum number of bonds to include in the subgraph" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="nBitsPerHash" type="integer" value="4" label="number of bits to set per path" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="useHs" type="boolean" truevalue="--useHs 1" falsevalue="--useHs 0" checked="true" + label="include information about the number of hydrogens on each atom" /> + </when> + <when value="--torsions"> + <param name="fpSize" type="integer" value="2048" label="number of bits in the fingerprint" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="targetSize" type="integer" value="4" label="number of target bits in the fingerprint" help=""> + <validator type="in_range" min="1" /> + </param> + </when> + <when value="--morgan"> + <param name="fpSize" type="integer" value="2048" label="number of bits in the fingerprint" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="radius" type="integer" value="2" label="radius for the Morgan algorithm" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="useFeatures" type="boolean" truevalue="--useFeatures 1" falsevalue="--useFeatures 0" checked="false" + label="include information about the number of hydrogens on each atom" /> + <param name="useChirality" type="boolean" truevalue="--useChirality 1" falsevalue="--useChirality 0" checked="false" + label="include information about the number of hydrogens on each atom" /> + <param name="useBondTypes" type="boolean" truevalue="--useBondTypes 1" falsevalue="--useBondTypes 0" checked="true" + label="include information about the number of hydrogens on each atom" /> + </when> + <when value="--pairs"> + <param name="fpSize" type="integer" value="2048" label="number of bits in the fingerprint" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="minLength" type="integer" value="1" label="minimum bond count for a pair" help=""> + <validator type="in_range" min="1" /> + </param> + <param name="maxLength" type="integer" value="30" label="maximum bond count for a pair" help=""> + <validator type="in_range" min="1" /> + </param> + </when> + <when value="--maccs166" /> + <when value="--substruct" /> + </conditional> + + </inputs> + <outputs> + <data name="outfile" format="fps" /> + </outputs> + <tests> + <!-- FP2 --> + <test> + <param name="infile" value="CID_2244.sdf" ftype="sdf" /> + <param name="fp_opts.fp_opts_selector" value="--FP2" /> + <output name="outfile" file="CID_2244_FP2.fps" ftype="fps" lines_diff="4"/> + </test> + <test> + <param name="infile" value="CID_2244.smi" ftype="smi" /> + <param name="fp_opts.fp_opts_selector" value="--FP2" /> + <output name="outfile" file="CID_2244_FP2.fps" ftype="fps" lines_diff="4"/> + </test> + <!-- FP3 --> + <test> + <param name="infile" value="CID_2244.sdf" ftype="sdf" /> + <param name="fp_opts.fp_opts_selector" value="--FP3" /> + <output name="outfile" file="CID_2244_FP3.fps" ftype="fps" lines_diff="4"/> + </test> + <test> + <param name="infile" value="CID_2244.smi" ftype="smi" /> + <param name="fp_opts.fp_opts_selector" value="--FP3" /> + <output name="outfile" file="CID_2244_FP3.fps" ftype="fps" lines_diff="4"/> + </test> + <!-- FP4 --> + <test> + <param name="infile" value="CID_2244.sdf" ftype="sdf" /> + <param name="fp_opts.fp_opts_selector" value="--FP4" /> + <output name="outfile" file="CID_2244_FP4.fps" ftype="fps" lines_diff="4"/> + </test> + <test> + <param name="infile" value="CID_2244.smi" ftype="smi" /> + <param name="fp_opts.fp_opts_selector" value="--FP4" /> + <output name="outfile" file="CID_2244_FP4.fps" ftype="fps" lines_diff="4"/> + </test> + <!-- MACCS --> + <test> + <param name="infile" value="CID_2244.sdf" ftype="sdf" /> + <param name="fp_opts.fp_opts_selector" value="--MACCS" /> + <output name="outfile" file="CID_2244_MACCS.fps" ftype="fps" lines_diff="4"/> + </test> + <test> + <param name="infile" value="CID_2244.smi" ftype="smi" /> + <param name="fp_opts.fp_opts_selector" value="--MACCS" /> + <output name="outfile" file="CID_2244_MACCS.fps" ftype="fps" lines_diff="4"/> + </test> + </tests> + <help> +<![CDATA[ + +.. class:: infomark + +**What this tool does** + +This tool uses chemfp_ to calculate 10 different fingerprints of common file formats. Chemfp uses `Open Babel`_, OpenEye_ and RDKit_. + +For more information check the websites listed below:: + + - http://www.rdkit.org/docs/GettingStartedInPython.html#fingerprinting-and-molecular-similarity + - http://openbabel.org/wiki/Tutorial:Fingerprints + +----- + +.. class:: infomark + +**Input** + +FPS fingerprint file format + +* Example:: + + - SDF File + + 28434379 + -OEChem-02031205132D + + 37 39 0 0 0 0 0 0 0999 V2000 + 8.1648 -1.8842 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 + 6.0812 -0.2134 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 + 6.0812 -1.8229 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 + 2.5369 -2.0182 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 + 6.3919 0.7371 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 7.3704 0.9433 0.0000 C 0 0 0 0 + ...... + 1 15 1 0 0 0 0 + 1 35 1 0 0 0 0 + 2 5 1 0 0 0 0 + 2 11 1 0 0 0 0 + 2 12 1 0 0 0 0 + 3 12 2 0 0 0 0 + 3 13 1 0 0 0 0 + 4 18 1 0 0 0 0 + ...... + + >PUBCHEM_COMPOUND_CID< + 28434379 + + > <PUBCHEM_COMPOUND_CANONICALIZED> + 1 + + > <PUBCHEM_CACTVS_COMPLEXITY> + 280 + + > <PUBCHEM_CACTVS_HBOND_ACCEPTOR> + 2 + + > <PUBCHEM_CACTVS_HBOND_DONOR> + 2 + + > <PUBCHEM_CACTVS_ROTATABLE_BOND> + 2 + + > <PUBCHEM_CACTVS_SUBSKEYS> + AAADceBzIAAAAAAAAAAAAAAAAAAAAWAAAAAwYAAAAAAAAFgB8AAAHgAQCAAACCjhlwYx0LdMEgCgASZiZASCgC0hEqAJ2CA4dJiKeKLA2dGUJAhokALYyCcQAAAAAACAAAQAACAAAQAACAAAQAAAAAAAAA== + + > + + - type : FP2 + +----- + +.. class:: infomark + +**Output** + +* Example:: + + #FPS1 + #num_bits=1021 + #type=OpenBabel-FP2/1 + #software=OpenBabel/2.3.0 + #source=/tmp/dataset_409.dat.sdf + #date=2012-02-03T11:13:39 + c0000000000008c0000846000400000000000010800000000000004000000000100010000700802170000018000000c + 0010000000020600208008000008000000c000c02c00002000000c00000100000008001400c800001c0180000000300 + 10000000000080000000c0000060000c0000060810000010000000800102000000 28434379 + + +]]> + </help> + <citations> + <citation type="doi">10.1186/1758-2946-3-33</citation> + <citation type="doi">10.1186/1758-2946-5-S1-P36</citation> + <citation type="bibtex"> + @electronic{rdkit, + title = {RDKit: Open-source cheminformatics}, + url ={http://www.rdkit.org} + } + </citation> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/nxn_clustering.py Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,80 @@ +#!/usr/bin/env python +""" + Modified version of code examples from the chemfp project. + http://code.google.com/p/chem-fingerprints/ + Thanks to Andrew Dalke of Andrew Dalke Scientific! +""" +import matplotlib +matplotlib.use('Agg') +import argparse +import os +import chemfp +import scipy.cluster.hierarchy as hcluster +import pylab +import numpy + +def distance_matrix(arena, tanimoto_threshold = 0.0): + n = len(arena) + # Start off a similarity matrix with 1.0s along the diagonal + try: + similarities = numpy.identity(n, "d") + except: + raise Exception('Input dataset is to large!') + chemfp.set_num_threads( args.processors ) + + ## Compute the full similarity matrix. + # The implementation computes the upper-triangle then copies + # the upper-triangle into lower-triangle. It does not include + # terms for the diagonal. + results = chemfp.search.threshold_tanimoto_search_symmetric(arena, threshold=tanimoto_threshold) + + # Copy the results into the NumPy array. + for row_index, row in enumerate(results.iter_indices_and_scores()): + for target_index, target_score in row: + similarities[row_index, target_index] = target_score + + # Return the distance matrix using the similarity matrix + return 1.0 - similarities + + +if __name__ == "__main__": + parser = argparse.ArgumentParser(description="""NxN clustering for fps files. +For more details please see the chemfp documentation: +https://chemfp.readthedocs.org +""") + + parser.add_argument("-i", "--input", dest="input_path", + required=True, + help="Path to the input file.") + + parser.add_argument("-c", "--cluster", dest="cluster_image", + help="Path to the output cluster image.") + + parser.add_argument("-s", "--smatrix", dest="similarity_matrix", + help="Path to the similarity matrix output file.") + + parser.add_argument("-t", "--threshold", dest="tanimoto_threshold", + type=float, default=0.0, + help="Tanimoto threshold [0.0]") + + parser.add_argument("--oformat", default='png', help="Output format (png, svg)") + + parser.add_argument('-p', '--processors', type=int, + default=4) + + args = parser.parse_args() + + targets = chemfp.open( args.input_path, format='fps' ) + arena = chemfp.load_fingerprints( targets ) + distances = distance_matrix( arena, args.tanimoto_threshold ) + + if args.similarity_matrix: + distances.tofile( args.similarity_matrix ) + + if args.cluster_image: + linkage = hcluster.linkage( distances, method="single", metric="euclidean" ) + + hcluster.dendrogram(linkage, labels=arena.ids) + + pylab.savefig( args.cluster_image, format=args.oformat ) +
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/nxn_clustering.xml Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,120 @@ +<tool id="ctb_chemfp_nxn_clustering" name="NxN Clustering" version="0.4"> + <description>of molecular fingerprints</description> + <requirements> + <requirement type="package" version="1.1p1">chemfp</requirement> + <requirement type="package" version="2">python</requirement> + <requirement type="package" version="2.0.2">matplotlib</requirement> + <requirement type="package" version="0.19.0">scipy</requirement> + <requirement type="package" version="2.4.1">openbabel</requirement> + </requirements> + <command detect_errors="exit_code"> +<![CDATA[ + python '$__tool_directory__/nxn_clustering.py' + -i '$infile' + -t $threshold + #if str($output_files) in ['both', 'image']: + --cluster '$image' + #end if + #if str($output_files) in ['both', 'matrix']: + --smatrix '$smilarity_matrix' + #end if + --oformat '$oformat' +]]> + </command> + <inputs> + <param name="infile" type="data" format="fps" label="Finperprint dataset" help="Dataset missing? See TIP below"/> + <param name='threshold' type='float' value='0.0' /> + <param name='oformat' type='select' format='text' label="Format of the resulting picture"> + <option value='png'>PNG</option> + <option value='svg'>SVG</option> + </param> + <param name='output_files' type='select' format='text' label="Output options"> + <option value='both'>NxN matrix and Image</option> + <option value='image'>Image</option> + <option value='matrix'>NxN Matrix</option> + </param> + + </inputs> + <outputs> + <data name="image" format="svg" label="${tool.name} on ${on_string} - Cluster Image"> + <filter>output_files == "both" or output_files == "image"</filter> + <change_format> + <when input="oformat" value="png" format="png"/> + </change_format> + </data> + <data name="smilarity_matrix" format="binary" label="${tool.name} on ${on_string} - Similarity Matrix"> + <filter>output_files == "both" or output_files == "matrix"</filter> + </data> + </outputs> + <tests> + <test> + <param name="infile" ftype="fps" value="targets.fps" /> + <param name='treshold' value='0.75' /> + <param name='oformat' value='svg' /> + <param name='output_files' value='image' /> + <output name="image" file='NxN_Clustering_on_q.svg' ftype="svg" compare="sim_size"/> + </test> + </tests> + <help> +<![CDATA[ + +.. class:: infomark + +**What this tool does** + +Generating hierarchical clusters and visualizing clusters with dendrograms. +For the clustering and the fingerprint handling the chemfp_ project is used. + +.. _chemfp: http://chemfp.com/ + +----- + +.. class:: warningmark + +**Hint** + +The plotting of the cluster image is sensible only with a small dataset. + +----- + +.. class:: infomark + +**Input** + +Molecular fingerprints in FPS format. Open Babel Fastsearch index is not supported. + +* Example:: + + - fingerprints in FPS format + + #FPS1 + #num_bits=881 + #type=CACTVS-E_SCREEN/1.0 extended=2 + #software=CACTVS/unknown + #source=/home/mohammed/galaxy-central/database/files/000/dataset_423.dat + #date=2012-02-09T13:20:37 + 07ce04000000000000000000000000000080060000000c000000000000001a800f0000780008100000701487e960cc0bed3248000580644626004101b4844805901b041c2e + 19511e45039b8b2926101609401b13e40800000000000100200000040080000010000002000000000000 55169009 + 07ce04000000000000000000000000000080060000000c000000000000001a800f0000780008100000701087e960cc0bed3248000580644626004101b4844805901b041c2e + 19111e45039b8b2926105609401313e40800000000000100200000040080000010000002000000000000 55079807 + ........ + + - Tanimoto threshold : 0.8 (between 0 and 1) + +----- + +.. class:: informark + +**Output** + +* Example:: + + .. image:: $PATH_TO_IMAGES/NxN_clustering.png + + +]]> + </help> + <citations> + <citation type="doi">10.1186/1758-2946-5-S1-P36</citation> + </citations> +</tool>
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/sdf2fps.xml Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,116 @@ +<tool id="ctb_sdf2fps" name="SDF to Fingerprint" version="0.2"> + <description>extract fingerprints from sdf files metadata</description> + <!--parallelism method="multi" split_inputs="infile" split_mode="to_size" split_size="10000" shared_inputs="" merge_outputs="outfile"></parallelism--> + <requirements> + <requirement type="package" version="1.1p1">chemfp</requirement> + <requirement type="package" version="2.4.1">openbabel</requirement> + </requirements> + <command> +<![CDATA[ + sdf2fps --pubchem '${infile}' > '${outfile}' +]]> + </command> + <inputs> + <param name="infile" type='data' format="sdf" label="SDF file with fingerprints as metadata"/> + </inputs> + <outputs> + <data name="outfile" format="fps"/> + </outputs> + <tests> + <test> + <param name="infile" ftype="sdf" value="CID_2244.sdf" /> + <output name="outfile" file='sdf2fps_result1.fps' ftype="fps" lines_diff="4" /> + </test> + </tests> + <help> +<![CDATA[ + +.. class:: infomark + +**What this tool does** + +Read an input SD file, extract the fingerprints and store them in a FPS-file. + +----- + +.. class:: infomark + +**Input** + +`SD-Format`_ + +.. _`SD-Format`: http://en.wikipedia.org/wiki/Chemical_table_file + +* Example:: + + 28434379 + -OEChem-02031205132D + + 37 39 0 0 0 0 0 0 0999 V2000 + 8.1648 -1.8842 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 + 6.0812 -0.2134 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 + 6.0812 -1.8229 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 + 2.5369 -2.0182 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 + 6.3919 0.7371 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 7.3704 0.9433 0.0000 C 0 0 0 0 + ...... + 1 15 1 0 0 0 0 + 1 35 1 0 0 0 0 + 2 5 1 0 0 0 0 + 2 11 1 0 0 0 0 + 2 12 1 0 0 0 0 + 3 12 2 0 0 0 0 + 3 13 1 0 0 0 0 + 4 18 1 0 0 0 0 + ...... + + >PUBCHEM_COMPOUND_CID< + 28434379 + + > <PUBCHEM_COMPOUND_CANONICALIZED> + 1 + + > <PUBCHEM_CACTVS_COMPLEXITY> + 280 + + > <PUBCHEM_CACTVS_HBOND_ACCEPTOR> + 2 + + > <PUBCHEM_CACTVS_HBOND_DONOR> + 2 + + > <PUBCHEM_CACTVS_ROTATABLE_BOND> + 2 + + > <PUBCHEM_CACTVS_SUBSKEYS> + AAADceBzIAAAAAAAAAAAAAAAAAAAAWAAAAAwYAAAAAAAAFgB8AAAHgAQCAAACCjhlwYx0LdMEgCgASZiZASCgC0hEqAJ2CA4dJiKeKLA2dGUJAhokALYyCcQAAAAAACAAAQAACAAAQAACAAAQAAAAAAAAA== + + > + +----- + +.. class:: infomark + +**Output** + +* Example:: + + #FPS1 + #num_bits=881 + #type=CACTVS-E_SCREEN/1.0 extended=2 + #software=CACTVS/unknown + #source=/home/mohammed/galaxy-central/database/files/000/dataset_409.dat + #date=2012-02-03T10:44:12 + 07ce04000000000000000000000000000080060000000c0600 + 00000000001a800f0000780008100000101487e9608c0bed32 + 48000580644626204101b4844805901b041c2e19511e45039b + 8b2924101609401b13e4080000000000010020000004008000 + 0010000002000000000000 28434379 + + +]]> + </help> + <citations> + <citation type="doi">10.1186/1758-2946-5-S1-P36</citation> + </citations> +</tool>
--- a/simsearch.xml Sat May 20 12:44:31 2017 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,121 +0,0 @@ -<tool id="ctb_simsearch" name="Similarity Search" version="0.2"> - <description>of fingerprint data sets</description> - <requirements> - <requirement type="package" version="1.1p1">chemfp</requirement> - </requirements> - <command> -<![CDATA[ - #if $method_opts.method_opts_selector == "chemfp": - ln -s '${method_opts.query_opts.targets}' ./targets.fps && - - #if $method_opts.query_opts.query_opts_selector == "normal": - ln -s '${method_opts.query_opts.query}' ./query.fps && - #end if - - simsearch - #if int($method_opts.knn) == 0: - #set $k = 'all' - ## count is only available if k nearest neighbor search is disabled - $method_opts.counts - #else: - #set $k = int($method_opts.knn) - #end if - - -k $k - --threshold $method_opts.threshold - -o ./output.fps - - ## build and search an in-memory data structure (faster for multiple queries) - --memory - - #if $method_opts.query_opts.query_opts_selector == "normal": - -q ./query.fps - #else: - --NxN - #end if - - ./targets.fps - && - mv ./output.fps '${outfile}' - #else: - ## OpenBabel needs the original molecule file (molecule.'fileformat') next to the fastsearch index (molecule.fs). We use a composite datatype to accomplish that. - ## Furthermore OpenBabel is really picky with file extensions. We need to specify every datatype. I did not find a solution to specify the query-filetype. - ## A workaround is to create a symlink with a proper file-extension. - ln -s '$method_opts.query' ./temp_query.$method_opts.query.ext - obabel - -i fs '$method_opts.fastsearch.files_path/molecule.fs' - -S ./temp_query.$method_opts.query.ext - -at${method_opts.threshold} - -O '${outfile}' - -osmi - -aa - #end if -]]> - </command> - <inputs> - <conditional name="method_opts"> - <param name="method_opts_selector" type="select" label="Subject database/sequences"> - <option value="chemfp">Chemfp fingerprint file</option> - <option value="obabel">OpenBabel Fastsearch Index</option> - </param> - <when value="chemfp"> - <conditional name="query_opts"> - <param name="query_opts_selector" type="select" label="Query Mode"> - <option value="normal">Query molecules are stores in a separate file</option> - <option value="nxn">Target molecules are also queries (NxN)</option> - </param> - <when value="normal"> - <param name='query' type='data' format="fps" label='Query molecules'/> - <param name='targets' type='data' format="fps" label='Target molecules'/> - </when> - <when value="nxn"> - <param name='targets' type='data' format="fps" label='Target moleculs'/> - </when> - </conditional> - <param name='knn' type='integer' value='0' label='select the k nearest neighbors' help='0 means all neighbors'> - <validator type="in_range" min="0" /> - </param> - <param name='threshold' type='float' value='0.7' label='threshold' /> - <param name="counts" type="boolean" truevalue="-c" falsevalue="" checked="false" label="report counts (-c)" help="Is ignored if k nearest neighbor search is enabled" /> - </when> - <when value="obabel"> - <param name="query" type='data' format="smi,mol,sdf,inchi" label="query"/> - <param name="fastsearch" type='data' format="obfs" label="OpenBabel Fastsearch Index"/> - <param name="threshold" type='float' label="threshold" value='0.7'/> - </when> - </conditional> - - </inputs> - <outputs> - <data name="outfile" format="tabular" /> - </outputs> - <tests> - <test> - <param name="targets" ftype="fps" value="targets.fps"/> - <param name="query" ftype="fps" value="q.fps"/> - <param name="k" value='4'/> - <param name="th" value='0.7'/> - <output name="outfile" ftype="tabular" file="simsearch_on_tragets_and_q.tabular"/> - </test> - </tests> - <help> -<![CDATA[ - - -.. class:: infomark - -**What this tool does** - -Similarity searches using a variety of different fingerprints using either the chemfp_ FPS type or the Open Babel FastSearch_ index. - -.. _chemfp: http://chemfp.com/ -.. _FastSearch: http://openbabel.org/wiki/FastSearch - - -]]> - </help> - <citations> - <citation type="doi">10.1186/1758-2946-3-33</citation> - <citation type="doi">10.1186/1758-2946-5-S1-P36</citation> - </citations> -</tool>
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244.sdf Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,154 @@ +2244 + -OEChem-05151212332D + + 21 21 0 0 0 0 0 0 0999 V2000 + 3.7320 -0.0600 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 + 6.3301 1.4400 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 + 4.5981 1.4400 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 + 2.8660 -1.5600 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 + 4.5981 -0.5600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 5.4641 -0.0600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 4.5981 -1.5600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 6.3301 -0.5600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 5.4641 -2.0600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 6.3301 -1.5600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 5.4641 0.9400 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 2.8660 -0.5600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 2.0000 -0.0600 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 + 4.0611 -1.8700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 6.8671 -0.2500 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 5.4641 -2.6800 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 6.8671 -1.8700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 2.3100 0.4769 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 1.4631 0.2500 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 1.6900 -0.5969 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 6.3301 2.0600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 + 1 5 1 0 0 0 0 + 1 12 1 0 0 0 0 + 2 11 1 0 0 0 0 + 2 21 1 0 0 0 0 + 3 11 2 0 0 0 0 + 4 12 2 0 0 0 0 + 5 6 1 0 0 0 0 + 5 7 2 0 0 0 0 + 6 8 2 0 0 0 0 + 6 11 1 0 0 0 0 + 7 9 1 0 0 0 0 + 7 14 1 0 0 0 0 + 8 10 1 0 0 0 0 + 8 15 1 0 0 0 0 + 9 10 2 0 0 0 0 + 9 16 1 0 0 0 0 + 10 17 1 0 0 0 0 + 12 13 1 0 0 0 0 + 13 18 1 0 0 0 0 + 13 19 1 0 0 0 0 + 13 20 1 0 0 0 0 +M END +> <PUBCHEM_COMPOUND_CID> +2244 + +> <PUBCHEM_COMPOUND_CANONICALIZED> +1 + +> <PUBCHEM_CACTVS_COMPLEXITY> +212 + +> <PUBCHEM_CACTVS_HBOND_ACCEPTOR> +4 + +> <PUBCHEM_CACTVS_HBOND_DONOR> +1 + +> <PUBCHEM_CACTVS_ROTATABLE_BOND> +3 + +> <PUBCHEM_CACTVS_SUBSKEYS> +AAADccBwOAAAAAAAAAAAAAAAAAAAAAAAAAAwAAAAAAAAAAABAAAAGgAACAAADASAmAAyDoAABgCIAiDSCAACCAAkIAAIiAEGCMgMJzaENRqCe2Cl4BEIuYeIyCCOAAAAAAAIAAAAAAAAABAAAAAAAAAAAA== + +> <PUBCHEM_IUPAC_OPENEYE_NAME> +2-acetoxybenzoic acid + +> <PUBCHEM_IUPAC_CAS_NAME> +2-acetyloxybenzoic acid + +> <PUBCHEM_IUPAC_NAME> +2-acetyloxybenzoic acid + +> <PUBCHEM_IUPAC_SYSTEMATIC_NAME> +2-acetyloxybenzoic acid + +> <PUBCHEM_IUPAC_TRADITIONAL_NAME> +2-acetoxybenzoic acid + +> <PUBCHEM_IUPAC_INCHI> +InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) + +> <PUBCHEM_IUPAC_INCHIKEY> +BSYNRYMUTXBXSQ-UHFFFAOYSA-N + +> <PUBCHEM_XLOGP3> +1.2 + +> <PUBCHEM_EXACT_MASS> +180.042259 + +> <PUBCHEM_MOLECULAR_FORMULA> +C9H8O4 + +> <PUBCHEM_MOLECULAR_WEIGHT> +180.15742 + +> <PUBCHEM_OPENEYE_CAN_SMILES> +CC(=O)OC1=CC=CC=C1C(=O)O + +> <PUBCHEM_OPENEYE_ISO_SMILES> +CC(=O)OC1=CC=CC=C1C(=O)O + +> <PUBCHEM_CACTVS_TPSA> +63.6 + +> <PUBCHEM_MONOISOTOPIC_WEIGHT> +180.042259 + +> <PUBCHEM_TOTAL_CHARGE> +0 + +> <PUBCHEM_HEAVY_ATOM_COUNT> +13 + +> <PUBCHEM_ATOM_DEF_STEREO_COUNT> +0 + +> <PUBCHEM_ATOM_UDEF_STEREO_COUNT> +0 + +> <PUBCHEM_BOND_DEF_STEREO_COUNT> +0 + +> <PUBCHEM_BOND_UDEF_STEREO_COUNT> +0 + +> <PUBCHEM_ISOTOPIC_ATOM_COUNT> +0 + +> <PUBCHEM_COMPONENT_COUNT> +1 + +> <PUBCHEM_CACTVS_TAUTO_COUNT> +1 + +> <PUBCHEM_COORDINATE_TYPE> +1 +5 +255 + +> <PUBCHEM_BONDANNOTATIONS> +5 6 8 +5 7 8 +6 8 8 +7 9 8 +8 10 8 +9 10 8 + +$$$$
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244.smi Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,1 @@ +O(c1c(cccc1)C(=O)O)C(=O)C 2244
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244_FP2.fps Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,7 @@ +#FPS1 +#num_bits=1021 +#type=OpenBabel-FP2/1 +#software=OpenBabel/2.4.1 +#source=/tmp/tmptaAke4/files/000/dataset_3.dat +#date=2017-05-19T13:52:59 +00000010004000c00000020000030000010000000008000000000080000000000400400000000010200a020800000000000042000000000000800002000002000c200800010001010000000002808002208000400000000040080000000100000008000000000002004002000010000000020100080100200808000000000004 2244
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244_FP3.fps Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,7 @@ +#FPS1 +#num_bits=1021 +#type=OpenBabel-FP2/1 +#software=OpenBabel/2.4.1 +#source=/tmp/tmptaAke4/files/000/dataset_7.dat +#date=2017-05-19T13:53:45 +00000010004000c00000020000030000010000000008000000000080000000000400400000000010200a020800000000000042000000000000800002000002000c200800010001010000000002808002208000400000000040080000000100000008000000000002004002000010000000020100080100200808000000000004 2244
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244_FP4.fps Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,7 @@ +#FPS1 +#num_bits=1021 +#type=OpenBabel-FP2/1 +#software=OpenBabel/2.4.1 +#source=/tmp/tmptaAke4/files/000/dataset_11.dat +#date=2017-05-19T13:54:39 +00000010004000c00000020000030000010000000008000000000080000000000400400000000010200a020800000000000042000000000000800002000002000c200800010001010000000002808002208000400000000040080000000100000008000000000002004002000010000000020100080100200808000000000004 2244
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244_MACCS.fps Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,7 @@ +#FPS1 +#num_bits=1021 +#type=OpenBabel-FP2/1 +#software=OpenBabel/2.4.1 +#source=/tmp/tmptaAke4/files/000/dataset_15.dat +#date=2017-05-19T13:55:30 +00000010004000c00000020000030000010000000008000000000080000000000400400000000010200a020800000000000042000000000000800002000002000c200800010001010000000002808002208000400000000040080000000100000008000000000002004002000010000000020100080100200808000000000004 2244
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/CID_2244_maccs.fps Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,7 @@ +#FPS1 +#num_bits=166 +#type=OpenBabel-MACCS/2 +#software=OpenBabel/2.3.1 +#source=CID_2244.sdf +#date=2012-05-15T17:00:39 +0000000000000000000000010000016480cca2d21e 2244
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--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/Taylor-Butina_Clustering_on_data_q.txt Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,4 @@ +#0 true singletons +#0 false singletons +#clusters: 1 +55091752 12 6499094 6485578 55079807 3153534 55102353 55091466 55091416 6485577 55169009 55091467 55168823 55091849
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/test-data/sdf2fps_result1.fps Sat May 20 12:56:09 2017 -0400 @@ -0,0 +1,7 @@ +#FPS1 +#num_bits=881 +#type=CACTVS-E_SCREEN/1.0 extended=2 +#software=CACTVS/unknown +#source=/tmp/tmpN2w37z/files/000/dataset_1.dat +#date=2017-05-19T14:27:41 +030e1c000000000000000000000000000000000000000c00000000000000008000000058000010000030200119004c70010060001140044b100040100024040010118060101330e46c21ac5841de06a50788109de11113047100000000001000000000000000080000000000000000 2244
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