# HG changeset patch # User saketkc # Date 1397581206 14400 # Node ID 699ab41c6d764f072ebadb64538087ee93936d31 # Parent 84247b644a7d29e288d44d698f1f991c6ae5a32b Uploaded diff -r 84247b644a7d -r 699ab41c6d76 condel_web/condel_web.xml --- a/condel_web/condel_web.xml Mon Apr 14 21:37:22 2014 -0400 +++ b/condel_web/condel_web.xml Tue Apr 15 13:00:06 2014 -0400 @@ -2,7 +2,9 @@ Condel web service requests + pycurl requests + pycurl condel_web.py --input $input --output $output @@ -15,7 +17,7 @@ - + @@ -36,6 +38,53 @@ dataset of approximately 20000 missense SNPs, both deleterious and neutral. The probability that a predicted deleterious mutation is not a false positive of the method and the probability that a predicted neutral mutation is not a false negative are employed as weights. + **Input** + + There are two main formats allowed: + + + SNVs may be submitted for analysis both in chromosome and protein coordinates. + + + The chromosome coordinates (hg19) input must follow this format: + + + [CHROMOSOME] [START] [END] [MUTANT_NUCLEOTIDE] + + + + The END column is the same as the START for SNVs. + Those four columns must be separated by tabs. Also a fifth column can optionally be added with the Variant name + + + Ex: + + 9 32473058 32473058 A + + 7 43918688 43918688 C + + Additionally, the input could be composed by two columns the strand of the SNV and an identifier: + + [PROTEIN_ID][variant] + + Also tab separated. Currently only Uniprot, RefSeq_Peptide and Ensembl identifiers are recognized by the webserver. + + The variant column must contain the following information (in this order ): change_position, reference_aminoacid and changed_aminoacid + + Ex: + + EGFR_HUMAN R521K + + EGFR_HUMAN R98Q + + .. class:: warningmark + + Note + + Please, note that the Variant Effect Predictor assumes that the allele submitted is coded in the forward strand. + + If you are assessing the effect of variants coded in the reverse strand, please introduce the complementary nucleotide instead. + **Citation** diff -r 84247b644a7d -r 699ab41c6d76 condel_web/test-data/condel_input.tsv --- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/condel_web/test-data/condel_input.tsv Tue Apr 15 13:00:06 2014 -0400 @@ -0,0 +1,5 @@ +9 32473058 32473058 A +7 43918688 43918688 C +7 38471790 38471790 A +6 88372821 88372821 A +5 41934236 41934236 G diff -r 84247b644a7d -r 699ab41c6d76 condel_web/test-data/condel_input.txt --- a/condel_web/test-data/condel_input.txt Mon Apr 14 21:37:22 2014 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,5 +0,0 @@ -9 32473058 32473058 A -7 43918688 43918688 C -7 38471790 38471790 A -6 88372821 88372821 A -5 41934236 41934236 G diff -r 84247b644a7d -r 699ab41c6d76 condel_web/tool_dependencies.xml --- a/condel_web/tool_dependencies.xml Mon Apr 14 21:37:22 2014 -0400 +++ b/condel_web/tool_dependencies.xml Tue Apr 15 13:00:06 2014 -0400 @@ -1,6 +1,9 @@ - - + + + + +