Mercurial > repos > morinlab > maftools
changeset 10:ab0d51ba4a7b draft default tip
Deleted selected files
| author | morinlab |
|---|---|
| date | Thu, 02 Mar 2017 17:05:08 -0500 |
| parents | a115ad0c696a |
| children | |
| files | oncostrip_gistic.R |
| diffstat | 1 files changed, 0 insertions(+), 98 deletions(-) [+] |
line wrap: on
line diff
--- a/oncostrip_gistic.R Thu Mar 02 17:04:59 2017 -0500 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,98 +0,0 @@ -require(maftools); -library(argparse); - -### - -parser <- ArgumentParser(description="Create an Oncostrip plot using Maftools"); - -parser$add_argument( - "--input_maf", "-maf", - required="True", - help="Input Variants in MAF format" - ); - -parser$add_argument( - "--gene_list", "-gl", - required="True", - help="Input gene list with separated by newline" - ); - - -parser$add_argument( - "--output_plot", "-o", - required="True", - help="Output directory to store gene plots" - ) - -parser$add_argument( - "--annotation_file", "-a", - help="Annotations for samples" - ) - -parser$add_argument( - "--gistic_all_lesions", "-gal", - help="GISTIC output file 1 of 3: all_lesions" -) - -parser$add_argument( - "--gistic_amp", "-ga", - help="GISTIC output file 2 of 3: amp") - -parser$add_argument( - "--gistic_del", "-gd", - help="GISTIC output file 3 of 3: amp") - -parser$add_argument( - "--sort_by", "-s", - required="True", - help="How to sort the matrix before visualizing, allowed options are 'anno' and 'gene'" - ) - -args <- parser$parse_args(); - -### -add_gistic = FALSE -if(!is.null(args$gistic_all_lesions)){ - file1 = args$gistic_all_lesions - file2 = args$gistic_amp - file3 = args$gistic_del - add_gistic = TRUE -} - -sort = FALSE -sort_by_anno = FALSE -if(args$sort_by == "anno"){ -sort_by_anno=TRUE -#print(paste("sort_by_anno",sort_by_anno)) -}else if(args$sort_by == "gene"){ -sort=TRUE -}else{ - - -} - -### - - - -all_genes <- read.table(args$gene_list, stringsAsFactors=FALSE)[,1] -if(!add_gistic){ -laml = read.maf(maf = args$input_maf, removeSilent = T, useAll = T) -}else{ -laml = read.maf(maf = args$input_maf, removeSilent = T, useAll = T,gisticAllLesionsFile = file1, gisticAmpGenesFile = file2, gisticDelGenesFile = file3) -} -count = 1 -pdf(args$output_plot,width=20,height=20) - - genes.have = laml@gene.summary[,Hugo_Symbol] - all_genes = all_genes[all_genes %in% genes.have] - - - if(is.null(args$annotation_file)){ - oncostrip(maf = laml, gene = all_genes, showTumorSampleBarcodes= FALSE, sort=sort) - }else{ - df = as.data.frame(read.table(args$annotation_file,sep="\t")) - oncostrip(maf = laml, gene = all_genes, showTumorSampleBarcodes= FALSE, sort=sort,sort_by_anno=sort_by_anno,annotation=df) - - } - dev.off()
