# HG changeset patch # User iuc # Date 1430534842 14400 # Node ID 104afefe24a81dbef418d68e71ff85578362b82a # Parent 98a5d415d504809514fadea06c813f6c6979198c Uploaded diff -r 98a5d415d504 -r 104afefe24a8 snpSift_geneSets.xml --- a/snpSift_geneSets.xml Fri May 01 22:37:14 2015 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,67 +0,0 @@ - - Annotating GeneSets, such as Gene Ontology, KEGG, Reactome - - - - snpSift_macros.xml - - - java -Xmx2G -jar \$SNPEFF_JAR_PATH/SnpSift.jar geneSets -v - #if $db_opts.db_opts_selector == "db" - "${db_opts.database.fields.path}" - #elif $db_opts.db_opts_selector == "histdb" - "$db_opts.histdb" - #end if - - $input 2> $log > $output - - - - - - - - - - - - - - - - - - - - - - - - - - - -This tool uses `SnpSift GeneSets`_ to add annotations from `MSigDB`_, a collection of annotated gene sets from different sources including Gene Ontology (GO), KEGG, Reactome. - -.. _SnpSift GeneSets: http://snpeff.sourceforge.net/SnpSift.html#geneSets - -.. class:: warningmark - -The input VCF file must be annotated using SnpEff before performing GeneSets annotations. This is because the tool must know which gene the variant affects. - -@EXTERNAL_DOCUMENTATION@ - -@CITATION_SECTION@ - -For `MSigDB`_, please cite |Subramanian2005|_. - -.. _MSigDB: http://www.broadinstitute.org/gsea/msigdb/ -.. |Subramanian2005| replace:: Subramanian, A., *et al.* (2005) Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. *Proc. Natl. Acad. Sci. U.S.A.* 102(43), 15545-15550 -.. _Subramanian2005: http://www.pnas.org/content/102/43/15545 - - - 10.1073/pnas.0506580102 - - diff -r 98a5d415d504 -r 104afefe24a8 tool-data/snpeff_msigdb_database.loc.sample --- a/tool-data/snpeff_msigdb_database.loc.sample Fri May 01 22:37:14 2015 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,4 +0,0 @@ -## Molecular Signatures Database (MSigDB) for SnpEff. -## You can download MSigDb from http://www.broadinstitute.org/gsea/msigdb -#msigdb_id msigdb_name path_to_database -#msigdb_08_2014 MSigDB 08-2014 /data/msigdb/08_2014/msigdb.gmt