Mercurial > repos > hackdna > pathprint
comparison consensus.xml @ 0:0cebe436a553 draft default tip
Initial upload.
| author | hackdna |
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| date | Fri, 17 May 2013 14:29:33 -0400 |
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| -1:000000000000 | 0:0cebe436a553 |
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| 1 <tool id="pathprint-consensus" name="Create a Consensus"> | |
| 2 <command>consensus.r $input $threshold $output</command> | |
| 3 | |
| 4 <inputs> | |
| 5 <param name="input" type="data" label="Pathway Fingerprint" help="Submit a Pathway Fingerprint file from your history"/> | |
| 6 | |
| 7 <param name="threshold" type="select" label="Threshold" help="Select a threshold value"> | |
| 8 <option value="0.9">0.9</option> | |
| 9 <option value="0.8" selected="true">0.8 (default)</option> | |
| 10 <option value="0.7">0.7</option> | |
| 11 <option value="0.6">0.6</option> | |
| 12 <option value="0.5">0.5</option> | |
| 13 </param> | |
| 14 </inputs> | |
| 15 | |
| 16 <outputs> | |
| 17 <data format="tabular" name="output" label="Consensus Fingerprint"/> | |
| 18 </outputs> | |
| 19 | |
| 20 <stdio> | |
| 21 <exit_code range="1:" level="fatal" /> | |
| 22 </stdio> | |
| 23 | |
| 24 <help> | |
| 25 | |
| 26 **What it does** | |
| 27 | |
| 28 This tool identifies the most prevalent PathPrint value for each pathway across the submitted samples and produces a consensus PathPrint. | |
| 29 | |
| 30 The method calculates the mean value of the pathway activities across samples, and then applies the threshold such that if the mean is greater than threshold, the pathway is assigned a consensus of +1. If the mean is less than -threshold, a value of -1 is assigned. Otherwise, the consensus is assigned a value of 0. | |
| 31 | |
| 32 ----- | |
| 33 | |
| 34 **Input:** PathPrint fingerprint for multiple samples and a threshold value. | |
| 35 | |
| 36 **Output:** A single consensus PathPrint fingerprint representing the most commonly occurring value | |
| 37 | |
| 38 ----- | |
| 39 | |
| 40 Feedback is welcome. Please send your questions, comments and suggestions to scde@hsci.harvard.edu. | |
| 41 </help> | |
| 42 </tool> | |
| 43 |
