Mercurial > repos > galaxyp > mt2mq
view test-data/ft_output.tabular @ 0:8822dd8bfc71 draft
"planemo upload commit 53bcf55b73cb251446150026242b4d47d49d3469"
| author | galaxyp |
|---|---|
| date | Tue, 23 Jun 2020 11:45:29 +0000 |
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id name namespace genus species dataset_21368137 dataset_21368138 dataset_21368139 dataset_21368140 dataset_21368141 dataset_21368142 GO:0000014 single-stranded DNA endodeoxyribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.158851 0.457588 0.367933 0.0406378 0.212081 0.0528417 GO:0000023 maltose metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 14.0012 10.3973 8.3927600000000009 14.0098 14.1239 9.89496 GO:0000025 maltose catabolic process biological_process Escherichia Escherichia coli 0.0251304 0 0 0 0 0 GO:0000027 ribosomal large subunit assembly biological_process Clostridium Clostridium thermocellum 4.99521 34.9239 31.4675 127.056 96.2502 105.199 GO:0000027 ribosomal large subunit assembly biological_process Coprothermobacter Coprothermobacter proteolyticus 44.0266 70.1837 60.1184 57.3553 74.0795 40.3249 GO:0000027 ribosomal large subunit assembly biological_process Escherichia Escherichia coli 0.0285816 0 0 0 0 0.0653892 GO:0000030 mannosyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.50346 4.38419 2.69903 22.4856 20.2827 17.4859 GO:0000030 mannosyltransferase activity molecular_function Escherichia Escherichia coli 0.0323487 0 0.0586834 0 0 0 GO:0000034 adenine deaminase activity molecular_function Escherichia Escherichia coli 0.0149956 0 0.0278306 0 0 0 GO:0000034 adenine deaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.148644 0.127232 0.24592 0.0508594 0.103349 0.308642 GO:0000036 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process molecular_function Clostridium Clostridium thermocellum 26.7934 119.275 48.5853 525.102 397.776 543.996 GO:0000036 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.661 17.4161 23.2322 12.7903 10.7163 13.3766 GO:0000036 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process molecular_function Escherichia Escherichia coli 0 0 0.0413174 0 0 0.118199 GO:0000041 transition metal ion transport biological_process Clostridium Clostridium thermocellum 2.80498 29.9683 29.3116 37.9571 37.3748 29.8371 GO:0000041 transition metal ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0964385 0 0.631534 0.890674 0.653019 1.67182 GO:0000049 tRNA binding molecular_function Clostridium Clostridium thermocellum 120.077 577.193 382.252 1919.14 1656.7 1821.14 GO:0000049 tRNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 514.943 404.284 333.851 458.679 525.602 378.856 GO:0000049 tRNA binding molecular_function Escherichia Escherichia coli 0.979988 0 0.574971 0 0 0.0577249 GO:0000049 tRNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.76975 2.89815 6.21105 6.1176 3.16754 7.03193 GO:0000050 urea cycle biological_process Escherichia Escherichia coli 0.101785 0 0.0755531 0 0 0 GO:0000053 argininosuccinate metabolic process biological_process Escherichia Escherichia coli 0.101785 0 0.0755531 0 0 0 GO:0000062 fatty-acyl-CoA binding molecular_function Escherichia Escherichia coli 0.065864 0 0.0611642 0 0 0 GO:0000103 sulfate assimilation biological_process Clostridium Clostridium thermocellum 60.4918 642.736 558.276 836.882 834.009 1015.38 GO:0000103 sulfate assimilation biological_process Escherichia Escherichia coli 0.474196 0 0 0 0 0.189053 GO:0000104 succinate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.190617 0 0 0 0 0 GO:0000104 succinate dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0365776 0.0702438 0.13577 0.299411 0.260999 0.0973401 GO:0000105 histidine biosynthetic process biological_process Clostridium Clostridium thermocellum 50.019 106.794 75.405 312.907 305.015 318.959 GO:0000105 histidine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 18.6764 15.0269 9.61789 12.342 13.9724 11.9058 GO:0000105 histidine biosynthetic process biological_process Escherichia Escherichia coli 0.316439 0 0 0 0 0.217091 GO:0000105 histidine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.32484 2.6737 1.3264 3.74954 1.61237 3.18684 GO:0000107 imidazoleglycerol-phosphate synthase activity molecular_function Clostridium Clostridium thermocellum 9.3861 21.7098 11.9057 58.9753 64.8784 50.9841 GO:0000107 imidazoleglycerol-phosphate synthase activity molecular_function Escherichia Escherichia coli 0.0775299 0 0 0 0 0.146657 GO:0000107 imidazoleglycerol-phosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.321494 0.576652 0.67876 0.328982 0.481327 0.855364 GO:0000150 recombinase activity molecular_function Clostridium Clostridium thermocellum 1.54379 110.706 78.5557 19.1856 19.9128 16.8752 GO:0000150 recombinase activity molecular_function Escherichia Escherichia coli 0.373359 0 0 0 0 0.117487 GO:0000150 recombinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.222965 0.142728 0 0.152106 0.132735 0.197785 GO:0000155 phosphorelay sensor kinase activity molecular_function Clostridium Clostridium thermocellum 19.9886 84.8723 77.9795 264.234 251.512 235.083 GO:0000155 phosphorelay sensor kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 47.2634 42.6513 42.495 39.1395 45.3117 29.564 GO:0000155 phosphorelay sensor kinase activity molecular_function Escherichia Escherichia coli 1.52994 0 0.964103 0 0 0.159463 GO:0000155 phosphorelay sensor kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.01421 5.38767 2.94955 2.42178 1.27238 2.52586 GO:0000156 phosphorelay response regulator activity molecular_function Clostridium Clostridium thermocellum 3.25315 9.02579 9.47242 86.7788 82.4587 83.4675 GO:0000156 phosphorelay response regulator activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.162035 0.103709 0 0.138328 0.0482239 0.0359285 GO:0000156 phosphorelay response regulator activity molecular_function Escherichia Escherichia coli 0.524797 0 0.447726 0 0 0.379206 GO:0000160 phosphorelay signal transduction system biological_process Clostridium Clostridium thermocellum 70.2649 506.303 446.434 1488.2 1460.77 1693.63 GO:0000160 phosphorelay signal transduction system biological_process Coprothermobacter Coprothermobacter proteolyticus 100.956 79.8029 110.565 74.3182 89.4686 68.112 GO:0000160 phosphorelay signal transduction system biological_process Escherichia Escherichia coli 1.47681 0 1.9532 0 0 0.727399 GO:0000160 phosphorelay signal transduction system biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.51202 4.41789 3.26994 1.32585 1.20071 2.48618 GO:0000162 tryptophan biosynthetic process biological_process Clostridium Clostridium thermocellum 25.7733 153.11 351.052 477.749 265.751 313.128 GO:0000162 tryptophan biosynthetic process biological_process Escherichia Escherichia coli 0.132749 0 0.403341 0 0 0 GO:0000162 tryptophan biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.81597 0.102682 0.0724408 0.759484 0.268335 2.15878 GO:0000166 nucleotide binding molecular_function Clostridium Clostridium thermocellum 25.4954 114.889 85.4685 410.422 364.29 343.28 GO:0000166 nucleotide binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 372.746 157.945 210.439 117.333 140.82 118.404 GO:0000166 nucleotide binding molecular_function Escherichia Escherichia coli 0.793357 0 1.54038 0 0 0.800485 GO:0000166 nucleotide binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.14811 4.82353 3.46074 5.50809 2.69665 10.2888 GO:0000175 3'-5'-exoribonuclease activity molecular_function Clostridium Clostridium thermocellum 2.72492 16.2016 15.1478 61.5467 63.3508 61.82 GO:0000175 3'-5'-exoribonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.5488 53.4827 41.7801 34.7674 39.6371 35.03 GO:0000175 3'-5'-exoribonuclease activity molecular_function Escherichia Escherichia coli 0 0 0.0705914 0 0 0 GO:0000175 3'-5'-exoribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.21215 1.6291 0.62991 0.347386 0.227186 0.62081 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.480005 3.09628 2.75081 11.3416 10.0213 10.6301 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.0203 9.38784 6.66771 7.82058 9.52142 8.62006 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.108493 0.346878 0.671228 0.148027 0.0645879 0.478842 GO:0000213 tRNA-intron endonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.265668 0.514297 0 0.411078 0.0597915 0 GO:0000256 allantoin catabolic process biological_process Escherichia Escherichia coli 0.0191516 0 0 0 0 0.0947853 GO:0000270 peptidoglycan metabolic process biological_process Clostridium Clostridium thermocellum 3.4896 22.5746 12.9726 63.0136 57.2558 69.5533 GO:0000270 peptidoglycan metabolic process biological_process Escherichia Escherichia coli 0.252908 0 0 0 0 0 GO:0000271 polysaccharide biosynthetic process biological_process Clostridium Clostridium thermocellum 12.436 81.8708 65.7678 187.226 171.569 234.308 GO:0000271 polysaccharide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.0404176 0.0387858 0.149934 0.0619763 0.0541271 0.0537796 GO:0000271 polysaccharide biosynthetic process biological_process Escherichia Escherichia coli 0.103876 0 0.847052 0 0 0.0420406 GO:0000271 polysaccharide biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0636037 0.154116 0.113533 0.511504 0.13972300000000001 0.150796 GO:0000272 polysaccharide catabolic process biological_process Clostridium Clostridium thermocellum 274.016 450.016 409.901 1307.84 1243.32 1384.78 GO:0000286 alanine dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.111701 0.321908 0.103745 0 0.124727 0.0743471 GO:0000287 magnesium ion binding molecular_function Clostridium Clostridium thermocellum 122.057 815.864 703 2240.71 2045.67 2109.07 GO:0000287 magnesium ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 657.309 681.011 699.335 647.704 720.619 549.212 GO:0000287 magnesium ion binding molecular_function Escherichia Escherichia coli 7.77015 0 4.42353 0 0 1.51142 GO:0000287 magnesium ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 8.10883 14.3757 15.0581 15.1495 9.07 14.5199 GO:0000302 response to reactive oxygen species biological_process Clostridium Clostridium thermocellum 16.7778 159.381 159.13 520.725 417.94 348.992 GO:0000302 response to reactive oxygen species biological_process Escherichia Escherichia coli 0.0479276 0 0.0636902 0 0 0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.235748 0.227832 0 0.109621 0.235621 GO:0000398 mRNA splicing, via spliceosome biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.939701 0.259072 1.13035 1.35099 GO:0000413 protein peptidyl-prolyl isomerization biological_process Escherichia Escherichia coli 0.103098 0 0 0 0 0 GO:0000453 enzyme-directed rRNA 2'-O-methylation biological_process Clostridium Clostridium thermocellum 3.29626 6.52502 3.96548 21.0496 18.4026 15.9098 GO:0000453 enzyme-directed rRNA 2'-O-methylation biological_process Coprothermobacter Coprothermobacter proteolyticus 1.04605 1.09856 0.176907 1.79801 1.31821 0.824318 GO:0000453 enzyme-directed rRNA 2'-O-methylation biological_process Escherichia Escherichia coli 0 0 0.126794 0 0 0 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity molecular_function Escherichia Escherichia coli 0.0757071 0 0 0 0 0 GO:0000724 double-strand break repair via homologous recombination biological_process Clostridium Clostridium thermocellum 6.01112 21.2068 21.8854 50.7726 47.1347 58.1933 GO:0000724 double-strand break repair via homologous recombination biological_process Escherichia Escherichia coli 0.123465 0 0 0 0 0 GO:0000725 recombinational repair biological_process Escherichia Escherichia coli 0.00811755 0 0.0450612 0 0 0 GO:0000737 DNA catabolic process, endonucleolytic biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.345944 1.33071 1.63181 0.299909 0.261737 0.177217 GO:0000738 DNA catabolic process, exonucleolytic biological_process Escherichia Escherichia coli 0 0 0.0705914 0 0 0 GO:0000738 DNA catabolic process, exonucleolytic biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.254901 0.481252 0.621024 0.380786 0.114136 0.333252 GO:0000774 adenyl-nucleotide exchange factor activity molecular_function Clostridium Clostridium thermocellum 1.50831 35.3845 47.4473 28.9627 41.5985 54.1577 GO:0000774 adenyl-nucleotide exchange factor activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 27.0761 20.5796 21.4075 11.4793 16.9678 21.1717 GO:0000774 adenyl-nucleotide exchange factor activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.265116 0.231505 0.431174 GO:0000902 cell morphogenesis biological_process Clostridium Clostridium thermocellum 15.8469 88.3083 72.4931 241.257 235.342 248.508 GO:0000902 cell morphogenesis biological_process Coprothermobacter Coprothermobacter proteolyticus 154.516 156.139 179.37 181.218 209.801 168.777 GO:0000902 cell morphogenesis biological_process Escherichia Escherichia coli 0.019905 0 0.174787 0 0 0 GO:0000902 cell morphogenesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0791583 0.55719 1.51819 0.78311 0.494826 1.3323 GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity molecular_function Clostridium Clostridium thermocellum 7.9335 68.0065 34.1373 218.064 158.846 137.481 GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.629767 0.69147 0.835325 2.11789 0 1.55272 GO:0000908 taurine dioxygenase activity molecular_function Escherichia Escherichia coli 0.0692422 0 0 0 0 0 GO:0000917 barrier septum assembly biological_process Clostridium Clostridium thermocellum 171.595 868.735 578.205 2874.96 2706.63 3615.61 GO:0000917 barrier septum assembly biological_process Coprothermobacter Coprothermobacter proteolyticus 381.898 556.293 504.685 403.076 480.933 724.606 GO:0000917 barrier septum assembly biological_process Escherichia Escherichia coli 0.600213 0 0.0662161 0 0 0.228895 GO:0000917 barrier septum assembly biological_process Methanothermobacter Methanothermobacter thermautotrophicus 8.30122 13.182 9.61681 3.9548 3.80298 7.1035 GO:0000918 barrier septum site selection biological_process Clostridium Clostridium thermocellum 8.2863 55.6835 39.4115 137.04 122.542 115.444 GO:0000918 barrier septum site selection biological_process Coprothermobacter Coprothermobacter proteolyticus 62.4331 78.3751 78.5854 80.8657 99.0399 63.0687 GO:0000918 barrier septum site selection biological_process Escherichia Escherichia coli 0.0366505 0 0 0 0 0 GO:0000920 cell separation after cytokinesis biological_process Escherichia Escherichia coli 0.189693 0 0 0 0 0 GO:0000967 rRNA 5'-end processing biological_process Clostridium Clostridium thermocellum 20.5795 48.505 31.4653 157.155 119.907 115.06 GO:0000967 rRNA 5'-end processing biological_process Coprothermobacter Coprothermobacter proteolyticus 34.2826 19.954 8.7021 28.5855 23.0759 32.0424 GO:0000986 bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding molecular_function Escherichia Escherichia coli 0.149834 0 0.668882 0 0 0.181971 GO:0000987 core promoter proximal region sequence-specific DNA binding molecular_function Escherichia Escherichia coli 0.905059 0 0.261482 0 0 0 GO:0001046 core promoter sequence-specific DNA binding molecular_function Escherichia Escherichia coli 0 0 0.261482 0 0 0 GO:0001047 core promoter binding molecular_function Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:0001071 nucleic acid binding transcription factor activity molecular_function Escherichia Escherichia coli 0.175378 0 0 0 0 0 GO:0001123 transcription initiation from bacterial-type RNA polymerase promoter biological_process Clostridium Clostridium thermocellum 9.93467 48.7134 28.9363 146.277 129.107 131.137 GO:0001123 transcription initiation from bacterial-type RNA polymerase promoter biological_process Escherichia Escherichia coli 0.181673 0 0.107579 0 0 0.0917454 GO:0001141 transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding molecular_function Escherichia Escherichia coli 0.05675 0 0.096708 0 0 0.0693346 GO:0001407 glycerophosphodiester transport biological_process Clostridium Clostridium thermocellum 115.851 297.81 235.253 1285.84 1089.39 861.139 GO:0001407 glycerophosphodiester transport biological_process Coprothermobacter Coprothermobacter proteolyticus 188.38 65.4715 118.616 36.1918 34.5571 42.4546 GO:0001407 glycerophosphodiester transport biological_process Escherichia Escherichia coli 0.0416328 0 0.0978357 0 0 0 GO:0001514 selenocysteine incorporation biological_process Coprothermobacter Coprothermobacter proteolyticus 26.1395 27.937 22.6729 21.6123 26.0746 24.3582 GO:0001514 selenocysteine incorporation biological_process Escherichia Escherichia coli 0.126284 0 0 0 0 0 GO:0001516 prostaglandin biosynthetic process biological_process Escherichia Escherichia coli 0.143394 0 0 0 0 0 GO:0001522 pseudouridine synthesis biological_process Clostridium Clostridium thermocellum 18.7966 81.1052 74.3503 155.841 154.52 229.781 GO:0001522 pseudouridine synthesis biological_process Coprothermobacter Coprothermobacter proteolyticus 48.0913 36.6866 25.7054 38.5516 38.6416 31.1142 GO:0001522 pseudouridine synthesis biological_process Escherichia Escherichia coli 0.159289 0 0 0 0 0 GO:0001522 pseudouridine synthesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 2.16808 4.51064 4.43357 1.44687 1.7529 GO:0001671 ATPase activator activity molecular_function Escherichia Escherichia coli 0.0933276 0 0 0 0 0 GO:0001680 tRNA 3'-terminal CCA addition biological_process Escherichia Escherichia coli 0.0223111 0 0 0 0 0 GO:0001680 tRNA 3'-terminal CCA addition biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.15365 0.0742451 0.0614043 0.0178615 0 GO:0001682 tRNA 5'-leader removal biological_process Clostridium Clostridium thermocellum 7.86346 63.3051 50.074 182.415 160.09 200.806 GO:0001682 tRNA 5'-leader removal biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.77181 3.4195 3.27675 5.62935 1.25308 8.58045 GO:0001727 lipid kinase activity molecular_function Escherichia Escherichia coli 0 0 0.300724 0 0 0 GO:0001896 autolysis biological_process Escherichia Escherichia coli 0.189693 0 0 0 0 0 GO:0002084 protein depalmitoylation biological_process Escherichia Escherichia coli 0.17567 0 0 0 0 0 GO:0002097 tRNA wobble base modification biological_process Escherichia Escherichia coli 0.0261755 0 0 0 0 0 GO:0002098 tRNA wobble uridine modification biological_process Clostridium Clostridium thermocellum 0.432053 4.25612 3.46669 11.5249 12.645 9.23874 GO:0002098 tRNA wobble uridine modification biological_process Coprothermobacter Coprothermobacter proteolyticus 10.7799 6.93449 5.37135 3.54892 5.13235 3.22302 GO:0002098 tRNA wobble uridine modification biological_process Escherichia Escherichia coli 0.0279254 0 0.1037 0 0 0 GO:0002098 tRNA wobble uridine modification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.427095 0.271734 0.529909 0.484967 0.289929 0.383604 GO:0002100 tRNA wobble adenosine to inosine editing biological_process Clostridium Clostridium thermocellum 4.98695 33.4582 24.2697 95.8039 74.3148 108.515 GO:0002100 tRNA wobble adenosine to inosine editing biological_process Coprothermobacter Coprothermobacter proteolyticus 2.08128 3.25926 2.86254 0.867992 1.23995 2.77157 GO:0002100 tRNA wobble adenosine to inosine editing biological_process Escherichia Escherichia coli 0.068659 0 0 0 0 0 GO:0002101 tRNA wobble cytosine modification biological_process Escherichia Escherichia coli 0 0 0.096708 0 0 0 GO:0002101 tRNA wobble cytosine modification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0205126 0.0787851 0 0.0419559 0.0366128 0.109176 GO:0002128 tRNA nucleoside ribose methylation biological_process Escherichia Escherichia coli 0.0862065 0 0 0 0 0 GO:0002128 tRNA nucleoside ribose methylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.103709 0.400725 0.331593 0 0 GO:0002143 tRNA wobble position uridine thiolation biological_process Coprothermobacter Coprothermobacter proteolyticus 589.086 181.098 207.717 182.833 172.107 155.817 GO:0002143 tRNA wobble position uridine thiolation biological_process Escherichia Escherichia coli 0.176107 0 0 0 0 0 GO:0002143 tRNA wobble position uridine thiolation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.51649 0.259226 0.142929 0 0.557555 GO:0002161 aminoacyl-tRNA editing activity molecular_function Clostridium Clostridium thermocellum 8.00437 54.505 41.5771 136.035 128.623 122.37 GO:0002161 aminoacyl-tRNA editing activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 158.284 105.064 94.5064 104.218 120.14 92.288 GO:0002161 aminoacyl-tRNA editing activity molecular_function Escherichia Escherichia coli 0.128714 0 0.0338298 0 0 0.0265826 GO:0002161 aminoacyl-tRNA editing activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.345749 0.644983 0.393372 0.488176 0.292013 0.470369 GO:0002237 response to molecule of bacterial origin biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0002935 tRNA (adenine-C2-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.7819 11.4019 8.76191 33.2804 31.5624 33.2572 GO:0002949 tRNA threonylcarbamoyladenosine modification biological_process Clostridium Clostridium thermocellum 7.44234 54.0843 40.7572 105.925 115.964 114.083 GO:0002949 tRNA threonylcarbamoyladenosine modification biological_process Coprothermobacter Coprothermobacter proteolyticus 81.1817 37.9727 56.9503 29.163 30.6186 29.4938 GO:0002949 tRNA threonylcarbamoyladenosine modification biological_process Escherichia Escherichia coli 0.171173 0 0 0 0 0 GO:0003333 amino acid transmembrane transport biological_process Escherichia Escherichia coli 0.936119 0 1.37101 0 0 0.476772 GO:0003676 nucleic acid binding molecular_function Clostridium Clostridium thermocellum 114.184 520.483 387.506 1648.95 1309.34 1509.48 GO:0003676 nucleic acid binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 309.965 429.289 376.093 304.893 314.471 286.154 GO:0003676 nucleic acid binding molecular_function Escherichia Escherichia coli 0.844274 0 0.297747 0 0 0.177929 GO:0003676 nucleic acid binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.43943 2.57666 1.88761 3.12896 0.811602 1.79743 GO:0003677 DNA binding molecular_function Clostridium Clostridium thermocellum 484.481 3689.01 3085.13 8844.89 8093.32 10257.2 GO:0003677 DNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 2840.89 4781.45 3624.97 2278.92 2771.38 2662.95 GO:0003677 DNA binding molecular_function Escherichia Escherichia coli 39.8095 0 31.1121 0 0 22.1497 GO:0003677 DNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 44.6392 87.6247 69.4342 114.896 62.6553 163.013 GO:0003678 DNA helicase activity molecular_function Clostridium Clostridium thermocellum 2.12709 13.591 7.47642 55.5768 47.5258 39.9705 GO:0003678 DNA helicase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.3331 9.32455 7.93813 13.0321 15.1196 9.34772 GO:0003678 DNA helicase activity molecular_function Escherichia Escherichia coli 0.139335 0 0 0 0 0 GO:0003684 damaged DNA binding molecular_function Clostridium Clostridium thermocellum 19.1707 131.229 98.1761 272.212 265.241 284.135 GO:0003684 damaged DNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 78.5822 94.9076 138.856 49.2771 60.6959 55.5058 GO:0003684 damaged DNA binding molecular_function Escherichia Escherichia coli 0.404322 0 0.260128 0 0 0.057789600000000003 GO:0003684 damaged DNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.899712 1.28665 2.63782 1.85623 0.385769 1.02181 GO:0003688 DNA replication origin binding molecular_function Clostridium Clostridium thermocellum 1.62361 6.62831 5.33811 16.0679 18.1539 20.2148 GO:0003688 DNA replication origin binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.1311 22.1648 29.882 8.47126 12.8847 8.72642 GO:0003688 DNA replication origin binding molecular_function Escherichia Escherichia coli 0.038765 0 0 0 0 0 GO:0003689 DNA clamp loader activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.283823 0.741224 0.305686 0.199036 0 0.179513 GO:0003690 double-stranded DNA binding molecular_function Clostridium Clostridium thermocellum 10.8248 63.0403 44.6454 121.369 122.721 152.282 GO:0003690 double-stranded DNA binding molecular_function Escherichia Escherichia coli 0.20131 0 0.0179072 0 0 0.0256771 GO:0003690 double-stranded DNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 7.15208 6.10864 6.2807 5.78837 4.03646 10.531 GO:0003697 single-stranded DNA binding molecular_function Clostridium Clostridium thermocellum 39.8208 196.064 115.522 746.779 632.797 587.862 GO:0003697 single-stranded DNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 207.604 188.811 196.58 120.494 161.102 121.232 GO:0003697 single-stranded DNA binding molecular_function Escherichia Escherichia coli 0.499959 0 1.08585 0 0 0.269609 GO:0003700 transcription factor activity, sequence-specific DNA binding molecular_function Clostridium Clostridium thermocellum 143.228 834.154 738.52 2142.51 1981.79 2353.96 GO:0003700 transcription factor activity, sequence-specific DNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 485.053 646.725 653.545 303.569 391.592 386.371 GO:0003700 transcription factor activity, sequence-specific DNA binding molecular_function Escherichia Escherichia coli 10.9995 0 7.20276 0 0 2.61932 GO:0003700 transcription factor activity, sequence-specific DNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 5.23905 16.7021 13.4066 11.2138 8.94321 15.445 GO:0003723 RNA binding molecular_function Clostridium Clostridium thermocellum 233.015 1271.13 1038.43 3440.49 3280.13 3683.11 GO:0003723 RNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 1029.51 793.117 821.333 594.596 668.05 485.255 GO:0003723 RNA binding molecular_function Escherichia Escherichia coli 3.6423 0 1.39131 0 0 0.920235 GO:0003723 RNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 11.5742 17.9269 11.8193 16.9188 7.91403 22.0151 GO:0003725 double-stranded RNA binding molecular_function Clostridium Clostridium thermocellum 2.84265 18.2528 13.1783 40.0871 42.5015 49.0472 GO:0003725 double-stranded RNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.56638 14.5919 8.13037 9.36121 9.15373 10.0155 GO:0003725 double-stranded RNA binding molecular_function Escherichia Escherichia coli 0.11491 0 0.0214706 0 0 0 GO:0003725 double-stranded RNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.172534 0.636721 0.820485 0.335896 0.448708 0.788519 GO:0003729 mRNA binding molecular_function Clostridium Clostridium thermocellum 14.2671 38.5654 16.046 202.671 181.592 134.609 GO:0003729 mRNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 72.3149 29.9106 22.1704 28.929 38.3661 16.9469 GO:0003729 mRNA binding molecular_function Escherichia Escherichia coli 0 0 0.16342 0 0 0 GO:0003735 structural constituent of ribosome molecular_function Clostridium Clostridium thermocellum 1124.36 7772.48 4272.95 24818.1 22466.8 28765.6 GO:0003735 structural constituent of ribosome molecular_function Coprothermobacter Coprothermobacter proteolyticus 7076.53 8854.01 6578.44 9683.54 10960.2 8803.02 GO:0003735 structural constituent of ribosome molecular_function Escherichia Escherichia coli 1.85664 0 2.01147 0 0 0.489223 GO:0003735 structural constituent of ribosome molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 26.9733 77.1491 97.7281 103.776 54.8019 85.1355 GO:0003743 translation initiation factor activity molecular_function Clostridium Clostridium thermocellum 15.4948 81.3768 66.6593 335.931 327.44 433.147 GO:0003743 translation initiation factor activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 186.109 192.414 183.507 190.529 201.449 172.004 GO:0003743 translation initiation factor activity molecular_function Escherichia Escherichia coli 0.189815 0 1.12852 0 0 0.0256447 GO:0003743 translation initiation factor activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.31753 11.5555 4.02295 11.0023 5.56011 10.3248 GO:0003746 translation elongation factor activity molecular_function Clostridium Clostridium thermocellum 77.4869 413.359 286.347 1635.73 1440.8 1509.42 GO:0003746 translation elongation factor activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 696.696 691.209 633.687 628.917 735.034 601.474 GO:0003746 translation elongation factor activity molecular_function Escherichia Escherichia coli 0.147987 0 0.0273344 0 0 0.245161 GO:0003746 translation elongation factor activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.41697 4.47698 3.78708 5.4333 2.41122 8.48663 GO:0003755 peptidyl-prolyl cis-trans isomerase activity molecular_function Clostridium Clostridium thermocellum 20.8325 125.125 91.5941 328.974 291.897 325.195 GO:0003755 peptidyl-prolyl cis-trans isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 7.12833 14.9748 13.5304 19.2067 19.5046 16.6573 GO:0003755 peptidyl-prolyl cis-trans isomerase activity molecular_function Escherichia Escherichia coli 0.103098 0 0.0942272 0 0 0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.176107 0.154816 1.21823 0.869957 0.330232 1.1555 GO:0003756 protein disulfide isomerase activity molecular_function Escherichia Escherichia coli 0.0814186 0 0 0 0 0 GO:0003774 motor activity molecular_function Clostridium Clostridium thermocellum 16.2424 61.3966 47.157 457.11 413.752 330.428 GO:0003774 motor activity molecular_function Escherichia Escherichia coli 0 0 0.0527744 0 0 0.042849 GO:0003796 lysozyme activity molecular_function Escherichia Escherichia coli 0.145265 0 0 0 0 0.0966933 GO:0003824 catalytic activity molecular_function Clostridium Clostridium thermocellum 137.316 831.273 713.52 2195.99 1939.11 1950.29 GO:0003824 catalytic activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 545.528 655.862 594.009 462.651 556.504 442.548 GO:0003824 catalytic activity molecular_function Escherichia Escherichia coli 7.69532 0 0.546509 0 0 2.76485 GO:0003824 catalytic activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 8.65781 16.738 10.6613 9.9622 6.538 10.5079 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.162546 0.139181 0 0.0741876 0 0.0482173 GO:0003839 gamma-glutamylcyclotransferase activity molecular_function Clostridium Clostridium thermocellum 0 1.46588 1.69992 1.48547 0.477746 0.915255 GO:0003840 gamma-glutamyltransferase activity molecular_function Escherichia Escherichia coli 0.0455458 0 0 0 0 0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity molecular_function Clostridium Clostridium thermocellum 5.997 47.2479 28.0874 116.149 110.111 121.998 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.8536 7.17812 8.30773 2.55001 3.206 4.34188 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.00636766 0 0 0 0 0 GO:0003844 1,4-alpha-glucan branching enzyme activity molecular_function Clostridium Clostridium thermocellum 1.36577 4.09104 3.84514 25.4212 28.2393 28.5431 GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity molecular_function Clostridium Clostridium thermocellum 1.06211 9.43031 7.26794 27.1576 18.0614 20.3111 GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.95863 3.78878 2.34332 5.25814 5.82665 4.74163 GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.265619 0.339924 0.32851 0 0.11852 0.1767 GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity molecular_function Clostridium Clostridium thermocellum 4.18625 33.5688 32.7505 51.4121 45.198 55.465 GO:0003852 2-isopropylmalate synthase activity molecular_function Clostridium Clostridium thermocellum 5.38225 20.4815 17.118 50.8821 40.6564 32.9352 GO:0003852 2-isopropylmalate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.391392 0.616792 0.364008 0.549779 0.158713 0.287396 GO:0003855 3-dehydroquinate dehydratase activity molecular_function Clostridium Clostridium thermocellum 1.38574 7.35655 3.7173 17.0606 15.9985 19.0732 GO:0003855 3-dehydroquinate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.376178 0.904535 0.524316 0 0.336482 0.500897 GO:0003856 3-dehydroquinate synthase activity molecular_function Clostridium Clostridium thermocellum 1.74464 17.7563 9.18415 61.5516 42.0406 30.4581 GO:0003856 3-dehydroquinate synthase activity molecular_function Escherichia Escherichia coli 0.155303 0 0 0 0 0 GO:0003856 3-dehydroquinate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123051 0.425617 0.274202 0.100799 0.109795 0.294898 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity molecular_function Escherichia Escherichia coli 0.172705 0 0 0 0 0.0158461 GO:0003861 3-isopropylmalate dehydratase activity molecular_function Clostridium Clostridium thermocellum 4.98129 49.7019 32.4344 154.533 108.949 61.6607 GO:0003861 3-isopropylmalate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.137391 1.1134 0.36464 0.535603 0.278926 0.291018 GO:0003862 3-isopropylmalate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 3.41508 16.4448 10.2752 56.2522 42.2691 32.7029 GO:0003862 3-isopropylmalate dehydrogenase activity molecular_function Escherichia Escherichia coli 0 0 0.0963923 0 0 0 GO:0003862 3-isopropylmalate dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0287031 0.110476 0 0.118009 0.0258265 0.0764815 GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 142.466 6.9546 14.7641 3.46147 3.02157 1.69925 GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.87409 6.84534 6.93312 13.2033 14.2757 17.5755 GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 28.2373 10.6405 11.762 11.5499 14.959 11.9443 GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity molecular_function Escherichia Escherichia coli 0.0376713 0 0 0 0 0 GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity molecular_function Clostridium Clostridium thermocellum 12.7106 54.7726 52.5702 144.858 144.756 140.053 GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity molecular_function Escherichia Escherichia coli 0.0428724 0 0 0 0 0 GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0875918 0.168212 0.162563 0.0672239 0.0391087 0 GO:0003867 4-aminobutyrate transaminase activity molecular_function Escherichia Escherichia coli 0.0217764 0 0.079748 0 0 0 GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0114958 0 0 0 0 0.0306249 GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0312793 0.120138 0.0580519 0.0640157 0.0837516 0.208101 GO:0003872 6-phosphofructokinase activity molecular_function Clostridium Clostridium thermocellum 12.712 116.88 72.6404 379.328 344.769 269.537 GO:0003872 6-phosphofructokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 233.381 310.772 242.865 253.449 310.629 177.948 GO:0003872 6-phosphofructokinase activity molecular_function Escherichia Escherichia coli 0.1493 0 0.0554808 0 0 0 GO:0003879 ATP phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.26044 0.569185 0.733068 4.23322 1.01539 0.85449 GO:0003879 ATP phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.21181 0 0.339561 0.227512 0.137748 0.441652 GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity molecular_function Escherichia Escherichia coli 0.0402961 0 0 0 0 0 GO:0003883 CTP synthase activity molecular_function Clostridium Clostridium thermocellum 2.99069 17.5081 9.72511 47.0376 51.3878 47.8895 GO:0003883 CTP synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 81.7573 30.9161 34.0033 28.7358 35.2159 18.6169 GO:0003883 CTP synthase activity molecular_function Escherichia Escherichia coli 0.163323 0 0 0 0 0 GO:0003883 CTP synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.133915 0.514297 0.186334 0.582359 0.0896765 0.400873 GO:0003886 DNA (cytosine-5-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.14213 0 0 0 GO:0003887 DNA-directed DNA polymerase activity molecular_function Clostridium Clostridium thermocellum 13.8017 113.47 81.4022 272.913 252.09 280.244 GO:0003887 DNA-directed DNA polymerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 193.276 136.463 164.902 92.8841 107.422 88.0927 GO:0003887 DNA-directed DNA polymerase activity molecular_function Escherichia Escherichia coli 1.29939 0 1.62008 0 0 0.107753 GO:0003887 DNA-directed DNA polymerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.562687 1.89994 1.70858 1.80634 1.05574 5.6378 GO:0003896 DNA primase activity molecular_function Clostridium Clostridium thermocellum 9.35849 55.0787 43.5957 155.68 132.08 144.945 GO:0003896 DNA primase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.8509 15.819 16.563 18.5483 22.5299 17.679 GO:0003896 DNA primase activity molecular_function Escherichia Escherichia coli 0 0 0.0282817 0 0 0 GO:0003896 DNA primase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.702339 0.957976 0.737489 0.738419 0.33008 1.21966 GO:0003899 DNA-directed RNA polymerase activity molecular_function Clostridium Clostridium thermocellum 31.4805 122.608 89.2892 472.668 417.922 393.303 GO:0003899 DNA-directed RNA polymerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 259.178 139.541 113.496 109.676 145.053 90.425 GO:0003899 DNA-directed RNA polymerase activity molecular_function Escherichia Escherichia coli 0.140842 0 0.0232749 0 0 0.0166869 GO:0003899 DNA-directed RNA polymerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 24.7246 24.1352 16.6017 37.8499 10.3458 36.8199 GO:0003904 deoxyribodipyrimidine photo-lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.265935 0.196403 0.151828 0 0.0730737 0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function Clostridium Clostridium thermocellum 8.44359 38.6602 41.3978 94.1453 87.3801 154.826 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 35.2144 18.7453 22.4538 18.0727 28.9692 25.5127 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function Escherichia Escherichia coli 0.100011 0 0 0 0 0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.164322 0.045388 0.235607 0.293152 GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0 1.01576 2.62726 5.81001 3.04457 5.45528 GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0 0.0848896 GO:0003909 DNA ligase activity molecular_function Escherichia Escherichia coli 0.090241 0 0.33505 0 0 0 GO:0003910 DNA ligase (ATP) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.110778 0.060769 0.117502 0.145714 0.0847716 0.126316 GO:0003911 DNA ligase (NAD+) activity molecular_function Clostridium Clostridium thermocellum 0.923554 8.33441 5.65561 19.559 20.7214 22.148 GO:0003911 DNA ligase (NAD+) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.0687 5.62109 6.50628 5.73657 6.64734 6.81345 GO:0003911 DNA ligase (NAD+) activity molecular_function Escherichia Escherichia coli 0.225396 0 0.0880927 0 0 0.0421052 GO:0003917 DNA topoisomerase type I activity molecular_function Clostridium Clostridium thermocellum 2.98451 17.6204 11.4183 60.2139 61.4208 56.995 GO:0003917 DNA topoisomerase type I activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.2855 14.3293 10.8965 6.45138 6.94773 5.49076 GO:0003917 DNA topoisomerase type I activity molecular_function Escherichia Escherichia coli 0.0198564 0 0.114796 0 0 0 GO:0003917 DNA topoisomerase type I activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.108979 0.0232435 0.179794 0.148649 0.194523 0.112798 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity molecular_function Clostridium Clostridium thermocellum 6.78066 44.6972 34.4645 123.05 113.338 115.841 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 44.4792 32.5295 35.4333 25.4426 27.668 20.7157 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity molecular_function Escherichia Escherichia coli 0.11909 0 0.0995948 0 0 0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.585217 2.24855 2.45496 0.509663 0.383816 0.268186 GO:0003919 FMN adenylyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.18476 13.2453 14.3414 40.3507 33.9304 35.5191 GO:0003919 FMN adenylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.502 12.0994 6.78476 11.8856 12.0771 13.8432 GO:0003919 FMN adenylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0794256 0.457588 0.588683 1.70599 0.70834 0.422734 GO:0003922 GMP synthase (glutamine-hydrolyzing) activity molecular_function Clostridium Clostridium thermocellum 3.92593 27.1335 16.1024 89.4446 80.4397 68.3222 GO:0003922 GMP synthase (glutamine-hydrolyzing) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 51.7973 29.7592 26.6445 20.2701 25.1246 15.1858 GO:0003922 GMP synthase (glutamine-hydrolyzing) activity molecular_function Escherichia Escherichia coli 0.03405 0 0 0 0 0 GO:0003922 GMP synthase (glutamine-hydrolyzing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.122249 0.46977 0.616198 0.126564 0.298849 0.890322 GO:0003924 GTPase activity molecular_function Clostridium Clostridium thermocellum 91.2264 448.433 297.561 1621.13 1364.53 1261.36 GO:0003924 GTPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 414.785 372.913 315.105 395.09 474.382 398.036 GO:0003924 GTPase activity molecular_function Escherichia Escherichia coli 0.619389 0 0.12711 0 0 0.410316 GO:0003924 GTPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 9.81184 12.6318 10.4115 6.31087 3.93702 7.44855 GO:0003933 GTP cyclohydrolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0602254 0 0.0558868 0.614964 0.671163 0.801358 GO:0003934 GTP cyclohydrolase I activity molecular_function Clostridium Clostridium thermocellum 2.75064 26.1507 22.8737 59.1885 55.363 59.7911 GO:0003934 GTP cyclohydrolase I activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.0869 27.9668 16.4539 22.0763 24.8876 25.081 GO:0003935 GTP cyclohydrolase II activity molecular_function Clostridium Clostridium thermocellum 2.5136 14.1421 9.7049 36.0382 30.5943 26.5774 GO:0003937 IMP cyclohydrolase activity molecular_function Clostridium Clostridium thermocellum 1.53247 2.87719 2.16578 36.1461 27.8234 16.8718 GO:0003937 IMP cyclohydrolase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0520107 0 0 0 0 0 GO:0003937 IMP cyclohydrolase activity molecular_function Escherichia Escherichia coli 0.0337826 0 0 0 0 0 GO:0003937 IMP cyclohydrolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.158851 0 0 0.433461 0.188729 0 GO:0003938 IMP dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 4.68312 31.4181 17.7155 99.2167 100.045 89.0826 GO:0003938 IMP dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 71.534 66.568 59.0969 42.1208 59.2179 36.5093 GO:0003938 IMP dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0369179 0 0 0 0 0 GO:0003938 IMP dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0745162 0.214605 0.449349 1.08578 0.133039 0.371444 GO:0003939 L-iditol 2-dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 1.04194 14.1858 11.3134 21.2411 23.4366 38.7121 GO:0003941 L-serine ammonia-lyase activity molecular_function Escherichia Escherichia coli 0.311432 0 0.127967 0 0 0 GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity molecular_function Clostridium Clostridium thermocellum 2.68978 9.57094 10.6172 33.7309 29.9122 30.1183 GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.274417 0.316447 0.10176 0.224826 0.637198 0.219193 GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity molecular_function Escherichia Escherichia coli 0.0568472 0 0 0 0 0 GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.301395 0.104409 0.756839 0.862297 0.295637 0.733446 GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity molecular_function Clostridium Clostridium thermocellum 9.34921 15.2183 14.147 55.5637 53.1404 46.2995 GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.585427 0 1.31747 0.181523 0.405918 GO:0003951 NAD+ kinase activity molecular_function Clostridium Clostridium thermocellum 3.27337 43.3958 38.1945 99.6322 94.2849 136.194 GO:0003951 NAD+ kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 34.3566 43.1891 33.5009 24.7099 33.9442 25.1287 GO:0003951 NAD+ kinase activity molecular_function Escherichia Escherichia coli 0.233368 0 0 0 0 0 GO:0003951 NAD+ kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.207727 0.398826 0.192649 0.070855 0.15459 0 GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity molecular_function Clostridium Clostridium thermocellum 2.21493 7.67324 6.91007 20.1786 15.2167 15.9144 GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 106.345 63.426 60.155 37.1686 45.6683 41.5932 GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0720129 0.276494 0.801901 0.294711 0.160819 0.670579 GO:0003954 NADH dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.1208 53.0885 39.1071 15.0276 21.1058 31.5373 GO:0003954 NADH dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0211688 0 0 0 0 0 GO:0003957 NAD(P)+ transhydrogenase (B-specific) activity molecular_function Escherichia Escherichia coli 0.0953691 0 0.07208 0 0 0.0517099 GO:0003960 NADPH:quinone reductase activity molecular_function Escherichia Escherichia coli 0.0582811 0 0 0 0 0 GO:0003961 O-acetylhomoserine aminocarboxypropyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.46716 11.5092 9.78537 35.8223 26.6286 19.0933 GO:0003962 cystathionine gamma-synthase activity molecular_function Escherichia Escherichia coli 0.0480734 0 0 0 0 0 GO:0003963 RNA-3'-phosphate cyclase activity molecular_function Escherichia Escherichia coli 0.0560695 0 0 0 0 0.0371574 GO:0003963 RNA-3'-phosphate cyclase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.224934 0.216099 0.208752 0.345421 0.175555 0.0748645 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity molecular_function Clostridium Clostridium thermocellum 6.26833 35.7007 27.2547 96.8199 94.1636 84.6506 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.0894 14.1176 12.1005 34.4997 35.4584 19.8786 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity molecular_function Escherichia Escherichia coli 0.019905 0 0.0738842 0 0 0 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.151609 0.166391 0.200994 0.15514 0.116067 0.172948 GO:0003978 UDP-glucose 4-epimerase activity molecular_function Clostridium Clostridium thermocellum 2.6548 27.3309 23.0112 46.6437 55.0428 57.194 GO:0003978 UDP-glucose 4-epimerase activity molecular_function Escherichia Escherichia coli 0.0280226 0 0 0 0 0 GO:0003978 UDP-glucose 4-epimerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.117413 0.11267 0.108932 0.420429 0.104868 0.546495 GO:0003979 UDP-glucose 6-dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 2.60525 8.90187 7.53177 29.0305 27.0512 28.6638 GO:0003979 UDP-glucose 6-dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0404176 0.0387858 0.149934 0.0619763 0.0541271 0.0537796 GO:0003979 UDP-glucose 6-dehydrogenase activity molecular_function Escherichia Escherichia coli 0.143394 0 0 0 0 0.0636106 GO:0003979 UDP-glucose 6-dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0636037 0.0813988 0.0787106 0.260141 0 0 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.00262 16.584 8.70638 40.1594 35.961 49.9037 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0869269 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.411541 1.18523 1.3379 0.63185 0.398466 0.410963 GO:0003984 acetolactate synthase activity molecular_function Clostridium Clostridium thermocellum 12.3166 82.6134 56.7822 225.977 186.613 134.043 GO:0003984 acetolactate synthase activity molecular_function Escherichia Escherichia coli 0.128107 0 0 0 0 0 GO:0003984 acetolactate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.10232 0.131013 0.205685 0.961728 0.287716 0.197397 GO:0003985 acetyl-CoA C-acetyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 26.0275 2.18932 2.51143 2.25821 2.2474 1.51585 GO:0003985 acetyl-CoA C-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.0471013 0 0 0 0 0.0626728 GO:0003987 acetate-CoA ligase activity molecular_function Escherichia Escherichia coli 0.0624857 0 0 0 0 0 GO:0003987 acetate-CoA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.321105 0.603863 0.128914 0.461639 0 0.431271 GO:0003988 acetyl-CoA C-acyltransferase activity molecular_function Escherichia Escherichia coli 0.0471013 0 0.0881829 0 0 0.0626728 GO:0003989 acetyl-CoA carboxylase activity molecular_function Clostridium Clostridium thermocellum 2.82617 21.9157 7.62902 73.9833 56.342 36.5976 GO:0003989 acetyl-CoA carboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.7308 24.1489 20.9167 25.6852 28.76 20.2805 GO:0003989 acetyl-CoA carboxylase activity molecular_function Escherichia Escherichia coli 0.0405149 0 0.431307 0 0 0.0539089 GO:0003991 acetylglutamate kinase activity molecular_function Clostridium Clostridium thermocellum 0.540085 2.86455 2.88893 11.9237 4.87905 5.78973 GO:0003991 acetylglutamate kinase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.103581 GO:0003991 acetylglutamate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.331896 0.127419 0.184846 0.203761 0.237191 0.353367 GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity molecular_function Clostridium Clostridium thermocellum 1.22298 3.18963 1.49848 18.1541 7.37558 5.86201 GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity molecular_function Escherichia Escherichia coli 0.0217764 0 0.079748 0 0 0 GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.118774 0.319248 0.264549 0.170087 0.212016 0.56897 GO:0003993 acid phosphatase activity molecular_function Clostridium Clostridium thermocellum 20.2842 21.6924 22.903 67.0532 58.2092 73.6737 GO:0003993 acid phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.114674 GO:0003994 aconitate hydratase activity molecular_function Clostridium Clostridium thermocellum 1.10559 12.6957 13.5628 26.4564 26.7358 26.7353 GO:0003994 aconitate hydratase activity molecular_function Escherichia Escherichia coli 0.00991605 0 0 0 0 0 GO:0003995 acyl-CoA dehydrogenase activity molecular_function Escherichia Escherichia coli 0.178829 0 0.0908442 0 0 0.315563 GO:0003999 adenine phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 5.3083 25.8836 13.0491 63.7916 59.4961 59.5095 GO:0003999 adenine phosphoribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 82.9271 58.608 43.511 37.0193 45.5653 50.1944 GO:0003999 adenine phosphoribosyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.224404 0 0 0 GO:0004000 adenosine deaminase activity molecular_function Escherichia Escherichia coli 0.028533 0 0 0 0 0 GO:0004003 ATP-dependent DNA helicase activity molecular_function Clostridium Clostridium thermocellum 8.84993 39.5339 36.4808 92.6987 88.1387 100.731 GO:0004003 ATP-dependent DNA helicase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 12.2596 9.9679 9.19547 12.8521 13.1056 10.1141 GO:0004003 ATP-dependent DNA helicase activity molecular_function Escherichia Escherichia coli 0.170104 0 0.269691 0 0 0.0384186 GO:0004003 ATP-dependent DNA helicase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.076655 0.0736043 0 0.117685 0.0456412 0.136017 GO:0004004 ATP-dependent RNA helicase activity molecular_function Escherichia Escherichia coli 0.160625 0 0.14619 0 0 0.1496 GO:0004008 copper-exporting ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.9607 6.2729799999999996 12.8348 2.63258 3.93105 6.52706 GO:0004013 adenosylhomocysteinase activity molecular_function Clostridium Clostridium thermocellum 4.23802 22.4967 18.8175 78.4721 77.705 67.3157 GO:0004013 adenosylhomocysteinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.9332 21.8965 19.3373 29.1334 37.6344 21.9112 GO:0004013 adenosylhomocysteinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.169052 0.0817327 0.315378 0.196498 0.263659 GO:0004014 adenosylmethionine decarboxylase activity molecular_function Clostridium Clostridium thermocellum 17.8211 150.459 93.7517 655.139 644.823 950.994 GO:0004014 adenosylmethionine decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 91.4887 110.189 143.464 72.4909 93.239 81.7297 GO:0004014 adenosylmethionine decarboxylase activity molecular_function Escherichia Escherichia coli 0 0 0.0699148 0 0 0.0501253 GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity molecular_function Clostridium Clostridium thermocellum 0.0595449 0.0762647 0.405281 0.710987 0.726831 0.501964 GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity molecular_function Escherichia Escherichia coli 0.0448653 0 0.0833114 0 0 0 GO:0004016 adenylate cyclase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0269706 GO:0004017 adenylate kinase activity molecular_function Clostridium Clostridium thermocellum 4.57971 10.556 6.43956 78.6257 34.4591 32.6999 GO:0004017 adenylate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 48.9564 13.5506 11.9735 20.7761 29.4811 23.4327 GO:0004017 adenylate kinase activity molecular_function Escherichia Escherichia coli 0.147307 0 0 0 0 0 GO:0004017 adenylate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.22209 0 1.10759 0.351738 0.366345 0.880976 GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function Clostridium Clostridium thermocellum 2.56609 19.096 13.0901 53.6147 49.7911 53.0492 GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 4.73713 3.81776 2.90485 3.76601 3.22935 2.67336 GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function Escherichia Escherichia coli 0.03981 0 0 0 0 0 GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.121496 0.350005 0.563694 0.559503 0.14465 0.107786 GO:0004019 adenylosuccinate synthase activity molecular_function Clostridium Clostridium thermocellum 3.47798 25.0905 23.5623 91.833 104.184 82.8417 GO:0004019 adenylosuccinate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 28.881 17.4687 14.6117 19.1518 24.4513 19.9258 GO:0004019 adenylosuccinate synthase activity molecular_function Escherichia Escherichia coli 0.0634579 0 0 0 0 0 GO:0004019 adenylosuccinate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.167042 0.107163 0.774972 1.16755 0.6956 1.11123 GO:0004020 adenylylsulfate kinase activity molecular_function Clostridium Clostridium thermocellum 0.117826 27.1204 16.2624 73.8219 53.4032 41.2491 GO:0004020 adenylylsulfate kinase activity molecular_function Escherichia Escherichia coli 0.108032 0 0 0 0 0 GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity molecular_function Escherichia Escherichia coli 0.0446465 0 0 0 0 0 GO:0004022 alcohol dehydrogenase (NAD) activity molecular_function Clostridium Clostridium thermocellum 0.658664 16.1959 9.70495 72.5495 65.9282 34.2944 GO:0004022 alcohol dehydrogenase (NAD) activity molecular_function Escherichia Escherichia coli 0.0920395 0 0.0900323 0 0 0 GO:0004029 aldehyde dehydrogenase (NAD) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.8536 7.17812 8.30773 2.55001 3.206 4.34188 GO:0004029 aldehyde dehydrogenase (NAD) activity molecular_function Escherichia Escherichia coli 0.348447 0 0.200453 0 0 0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity molecular_function Clostridium Clostridium thermocellum 0.229819 2.94146 1.49279 7.42607 6.99288 7.20601 GO:0004033 aldo-keto reductase (NADP) activity molecular_function Escherichia Escherichia coli 0.0585242 0 0 0 0 0.114189 GO:0004034 aldose 1-epimerase activity molecular_function Escherichia Escherichia coli 0.0545626 0 0 0 0 0 GO:0004038 allantoinase activity molecular_function Escherichia Escherichia coli 0.0191516 0 0 0 0 0.0947853 GO:0004040 amidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.61867 0.933472 0.451064 0.0826185 0.144693 0 GO:0004040 amidase activity molecular_function Escherichia Escherichia coli 0.069461 0 0.386697 0 0 0.0478939 GO:0004042 acetyl-CoA:L-glutamate N-acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.01251 3.48787 2.17638 14.6388 12.8624 11.5721 GO:0004042 acetyl-CoA:L-glutamate N-acetyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0917964 0.661038 0.553229 0.375812 0.122947 0.427488 GO:0004044 amidophosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.51317 2.48047 0.993152 14.8184 20.047 15.0013 GO:0004044 amidophosphoribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.168962 0.215445 0.174381 0.115397 0.268508 0.325038 GO:0004044 amidophosphoribosyltransferase activity molecular_function Escherichia Escherichia coli 0.0710651 0 0 0 0 0 GO:0004044 amidophosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.114351 0 0.141499 0.175533 0.0340519 0.0760934 GO:0004045 aminoacyl-tRNA hydrolase activity molecular_function Clostridium Clostridium thermocellum 1.21345 6.76945 3.54229 13.4902 13.2259 14.2407 GO:0004045 aminoacyl-tRNA hydrolase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.15117 7.60504 6.4982 7.70994 8.85166 7.6867 GO:0004047 aminomethyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 124.331 83.1919 115.231 65.8005 80.3797 46.756100000000004 GO:0004048 anthranilate phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.52973 28.3747 61.0337 96.7238 64.2943 66.0053 GO:0004048 anthranilate phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.801937 0.102682 0 0.246214 0.119388 1.10276 GO:0004049 anthranilate synthase activity molecular_function Clostridium Clostridium thermocellum 1.0371 8.84292 23.4419 51.5684 39.9127 91.704 GO:0004049 anthranilate synthase activity molecular_function Escherichia Escherichia coli 0.0925498 0 0 0 0 0 GO:0004049 anthranilate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.422526 0 0.0724408 0 0.0840771 0.510275 GO:0004055 argininosuccinate synthase activity molecular_function Clostridium Clostridium thermocellum 0.842014 1.79147 1.39365 14.9205 6.33647 8.23416 GO:0004055 argininosuccinate synthase activity molecular_function Escherichia Escherichia coli 0.101785 0 0.0755531 0 0 0 GO:0004055 argininosuccinate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.231375 0.666779 0.171855 0.378971 0.082623 0.307996 GO:0004056 argininosuccinate lyase activity molecular_function Clostridium Clostridium thermocellum 1.62409 2.70049 1.06591 12.8661 7.55014 6.66527 GO:0004056 argininosuccinate lyase activity molecular_function Escherichia Escherichia coli 0.0198564 0 0 0 0 0 GO:0004056 argininosuccinate lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.193217 0.185668 0.179343 0.197842 0.120864 0.0257418 GO:0004061 arylformamidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.5656 12.5449 8.71175 11.5431 10.73 8.61288 GO:0004061 arylformamidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.320352 0.531379 0.222735 0.184064 0.107169 0.319411 GO:0004065 arylsulfatase activity molecular_function Escherichia Escherichia coli 0.0322758 0 0.0299506 0 0 0 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity molecular_function Clostridium Clostridium thermocellum 0.0574548 0.220626 0.106631 0.26422 0.205223 0.324909 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0771897 0.074071 0.286425 0.176802 0.0344425 0.256641 GO:0004067 asparaginase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.5423 18.0342 17.5276 4.73572 8.79582 14.1388 GO:0004067 asparaginase activity molecular_function Escherichia Escherichia coli 0.195113 0 0.105549 0 0 0.0360579 GO:0004067 asparaginase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.230816 0.0805587 0 0.128802 0.0562323 0.0837254 GO:0004068 aspartate 1-decarboxylase activity molecular_function Clostridium Clostridium thermocellum 2.52193 14.4972 11.4945 32.9542 31.4178 34.2164 GO:0004068 aspartate 1-decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.9563 26.9304 27.2579 21.9174 19.4253 18.9558 GO:0004068 aspartate 1-decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0258109 0.148609 0 0.369296 0.115025 0 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function Clostridium Clostridium thermocellum 0.304384 15.5106 12.4246 54.3206 58.0849 85.4305 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 50.0765 13.7323 32.6144 4.60319 5.75173 6.46044 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function Escherichia Escherichia coli 0.0466881 0 0 0 0 0 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0498233 0.0956809 0.138792 0.561145 0.133625 0.0995068 GO:0004070 aspartate carbamoyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.431203 4.66759 5.1447 9.77018 11.9337 15.5682 GO:0004070 aspartate carbamoyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.8177 1.71465 2.95952 0.522123 0.484192 0.339526 GO:0004070 aspartate carbamoyltransferase activity molecular_function Escherichia Escherichia coli 0.217157 0 0 0 0 0 GO:0004070 aspartate carbamoyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123222 0.0591355 0.171494 0.0630458 0.10999 0.245873 GO:0004071 aspartate-ammonia ligase activity molecular_function Clostridium Clostridium thermocellum 2.00423 11.0108 9.29827 27.4214 27.3095 32.9501 GO:0004071 aspartate-ammonia ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.43158 29.0199 18.8658 23.913 24.1686 9.43613 GO:0004071 aspartate-ammonia ligase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.452292 GO:0004072 aspartate kinase activity molecular_function Clostridium Clostridium thermocellum 1.41736 14.388 11.0114 56.7087 52.8687 48.2522 GO:0004072 aspartate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0405149 0.155563 0.225261 0.0414585 0.253186 0.134724 GO:0004072 aspartate kinase activity molecular_function Escherichia Escherichia coli 0.103535 0 0.0395132 0 0 0 GO:0004072 aspartate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.113476 0.392152 0.421158 0.4643 0.121623 0.422508 GO:0004073 aspartate-semialdehyde dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 2.11693 7.52813 8.59258 20.3668 24.8744 25.0777 GO:0004073 aspartate-semialdehyde dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.274417 0.316447 0.10176 0.224826 0.637198 0.219193 GO:0004073 aspartate-semialdehyde dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.244572 0.104409 0.756839 0.862297 0.194176 0.506492 GO:0004075 biotin carboxylase activity molecular_function Escherichia Escherichia coli 0.0405149 0 0.150294 0 0 0.0539089 GO:0004075 biotin carboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.183277 0.175073 0.272127 0.262579 0.130934 0.292602 GO:0004076 biotin synthase activity molecular_function Clostridium Clostridium thermocellum 0.059788 0.287043 0.219803 0.64155 0.879272 1.82951 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 114.816 175.867 339.038 76.677 89.1209 71.4393 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function Escherichia Escherichia coli 0.178999 0 0 0 0 0 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.229212 0.51369 0.424992 0.70375 0.409274 0.101706 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity molecular_function Clostridium Clostridium thermocellum 2.04589 9.22471 6.84268 32.5625 32.4153 26.6028 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity molecular_function Escherichia Escherichia coli 0.0316439 0 0.0586834 0 0 0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.089682 0.382817 0 0.166978 0.199775 0.78784 GO:0004089 carbonate dehydratase activity molecular_function Escherichia Escherichia coli 0.189401 0 0.176005 0 0 0 GO:0004089 carbonate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.229307 0.236763 0.392003 0.113919 0.848346 GO:0004096 catalase activity molecular_function Escherichia Escherichia coli 0.0460319 0 0 0 0 0 GO:0004106 chorismate mutase activity molecular_function Escherichia Escherichia coli 0.0721101 0 0 0 0 0 GO:0004106 chorismate mutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.16534 0 0.306859 0 0.420168 0.432759 GO:0004107 chorismate synthase activity molecular_function Clostridium Clostridium thermocellum 5.75051 25.0653 17.4271 71.0047 56.8645 73.0903 GO:0004107 chorismate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.821817 1.10047 0.647006 0.841605 0.222477 0.431142 GO:0004108 citrate (Si)-synthase activity molecular_function Escherichia Escherichia coli 0.0206827 0 0 0 0 0 GO:0004109 coproporphyrinogen oxidase activity molecular_function Clostridium Clostridium thermocellum 0.562736 5.12201 2.95248 9.71208 10.8358 8.56095 GO:0004109 coproporphyrinogen oxidase activity molecular_function Escherichia Escherichia coli 0.0323973 0 0.0368519 0 0 0 GO:0004112 cyclic-nucleotide phosphodiesterase activity molecular_function Escherichia Escherichia coli 0.04924 0 0.049932699999999997 0 0 0 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity molecular_function Clostridium Clostridium thermocellum 2.05304 14.8595 15.0335 28.6236 25.8995 31.0351 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.57913 6.22052 4.92814 6.42321 4.33271 8.69916 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.718792 0.460995 0.222735 0.429706 0 0 GO:0004121 cystathionine beta-lyase activity molecular_function Escherichia Escherichia coli 0.0234048 0 0.0854314 0 0 0 GO:0004124 cysteine synthase activity molecular_function Clostridium Clostridium thermocellum 7.50952 930.533 633.388 1444.67 1267.68 1095.07 GO:0004124 cysteine synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.37537 20.7263 18.0253 14.2907 15.7527 11.2618 GO:0004124 cysteine synthase activity molecular_function Escherichia Escherichia coli 0.0662285 0 0.109744 0 0 0 GO:0004125 L-seryl-tRNASec selenium transferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.0747 16.9223 13.8159 13.3391 14.8082 17.0092 GO:0004125 L-seryl-tRNASec selenium transferase activity molecular_function Escherichia Escherichia coli 0.0976294 0 0 0 0 0 GO:0004126 cytidine deaminase activity molecular_function Clostridium Clostridium thermocellum 5.42019 15.356 8.18067 52.5126 48.2299 47.6837 GO:0004126 cytidine deaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.32507 6.71358 4.44036 6.02628 7.87614 12.1276 GO:0004127 cytidylate kinase activity molecular_function Clostridium Clostridium thermocellum 6.82242 51.3493 27.5884 104.762 118.867 125.629 GO:0004127 cytidylate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.2649 18.5374 13.7887 25.9076 30.2487 22.0955 GO:0004127 cytidylate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0723289 0.138901 0 0.740408 0.38718 0.77083 GO:0004129 cytochrome-c oxidase activity molecular_function Escherichia Escherichia coli 0.196595 0 0 0 0 0 GO:0004130 cytochrome-c peroxidase activity molecular_function Escherichia Escherichia coli 0.198613 0 0.071674 0 0 0 GO:0004133 glycogen debranching enzyme activity molecular_function Escherichia Escherichia coli 0.079936 0 0.148355 0 0 0 GO:0004134 4-alpha-glucanotransferase activity molecular_function Clostridium Clostridium thermocellum 1.08846 8.18431 6.03654 29.6421 28.7723 30.4393 GO:0004134 4-alpha-glucanotransferase activity molecular_function Escherichia Escherichia coli 0.0251304 0 0 0 0 0 GO:0004135 amylo-alpha-1,6-glucosidase activity molecular_function Clostridium Clostridium thermocellum 1.08846 8.18431 6.03654 29.6421 28.7723 30.4393 GO:0004139 deoxyribose-phosphate aldolase activity molecular_function Clostridium Clostridium thermocellum 2.09353 22.1003 15.1099 60.3665 37.74 60.8098 GO:0004139 deoxyribose-phosphate aldolase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 19.2405 14.345 7.7744 13.2134 16.1646 16.8584 GO:0004139 deoxyribose-phosphate aldolase activity molecular_function Escherichia Escherichia coli 0.0771654 0 0 0 0 0 GO:0004139 deoxyribose-phosphate aldolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.370175 0.347438 0.257738 0.142033 0.0826881 0.18514 GO:0004140 dephospho-CoA kinase activity molecular_function Clostridium Clostridium thermocellum 2.54852 12.0212 9.16164 26.7003 25.1749 24.24 GO:0004140 dephospho-CoA kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.53013 6.91068 3.33331 8.45888 9.64143 9.6497 GO:0004141 dethiobiotin synthase activity molecular_function Clostridium Clostridium thermocellum 0.0830956 0 0 0.339875 0.296787 0.663271 GO:0004141 dethiobiotin synthase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.11836 GO:0004146 dihydrofolate reductase activity molecular_function Clostridium Clostridium thermocellum 4.66723 34.7584 21.8931 95.8256 97.9612 69.4259 GO:0004148 dihydrolipoyl dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.81986 2.76564 3.19249 2.90617 2.96503 2.71446 GO:0004148 dihydrolipoyl dehydrogenase activity molecular_function Escherichia Escherichia coli 0 0 0.0707719 0 0 0 GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 202.561 37.4275 53.072 10.7665 10.0237 12.0631 GO:0004150 dihydroneopterin aldolase activity molecular_function Clostridium Clostridium thermocellum 1.92063 7.73797 5.93419 21.7524 18.4385 14.4682 GO:0004150 dihydroneopterin aldolase activity molecular_function Escherichia Escherichia coli 0.221945 0 0 0 0 0 GO:0004150 dihydroneopterin aldolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.379456 1.09942 0.202194 0 0.262398 GO:0004151 dihydroorotase activity molecular_function Clostridium Clostridium thermocellum 1.30386 9.1113 8.84441 22.6345 29.5918 35.1093 GO:0004151 dihydroorotase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.34572 1.02869 2.06898 0.776396 0.219221 0.0890936 GO:0004151 dihydroorotase activity molecular_function Escherichia Escherichia coli 0.054198 0 0 0 0 0 GO:0004151 dihydroorotase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0200022 0.230381 0.222735 0.307022 0.0893075 0.319411 GO:0004152 dihydroorotate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 0.785021 5.36028 4.36413 21.353 15.7481 14.4096 GO:0004152 dihydroorotate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0564583 0 0 0 0 0 GO:0004152 dihydroorotate dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.159386 0.122518 0.118404 0.195778 0.113897 0.0848896 GO:0004156 dihydropteroate synthase activity molecular_function Clostridium Clostridium thermocellum 3.17853 10.1689 6.98535 21.5581 22.3 22.5492 GO:0004156 dihydropteroate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.40281 14.4801 9.31383 15.9327 17.7981 11.6153 GO:0004156 dihydropteroate synthase activity molecular_function Escherichia Escherichia coli 0.0695339 0 0 0 0 0 GO:0004159 dihydrouracil dehydrogenase (NAD+) activity molecular_function Escherichia Escherichia coli 0 0 0.0414076 0 0 0.0593419 GO:0004160 dihydroxy-acid dehydratase activity molecular_function Clostridium Clostridium thermocellum 2.51826 20.572 13.8411 60.3785 49.4916 39.8605 GO:0004160 dihydroxy-acid dehydratase activity molecular_function Escherichia Escherichia coli 0.0267345 0 0 0 0 0 GO:0004160 dihydroxy-acid dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.147283 0.989854 0.273344 0.583702 0.164334 0.465163 GO:0004161 dimethylallyltranstransferase activity molecular_function Escherichia Escherichia coli 0.129589 0 0 0 0 0 GO:0004164 diphthine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.139875 0 0 0.200404 GO:0004165 dodecenoyl-CoA delta-isomerase activity molecular_function Escherichia Escherichia coli 0.0357513 0 0 0 0 0.0158461 GO:0004170 dUTP diphosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.62402 13.6576 7.89036 6.861 7.59871 11.9597 GO:0004170 dUTP diphosphatase activity molecular_function Escherichia Escherichia coli 0.0786479 0 0 0 0 0 GO:0004170 dUTP diphosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.159119 0.308093 0 0 0.143261 0 GO:0004175 endopeptidase activity molecular_function Escherichia Escherichia coli 0.203012 0 0 0 0 0.0379012 GO:0004175 endopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.488463 0.781783 0.453319 0.166505 0.217876 1.0818 GO:0004176 ATP-dependent peptidase activity molecular_function Clostridium Clostridium thermocellum 4.95467 17.5277 18.7012 53.4906 45.2308 49.6649 GO:0004176 ATP-dependent peptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.3745 14.8853 9.86895 18.6179 26.4482 29.9665 GO:0004176 ATP-dependent peptidase activity molecular_function Escherichia Escherichia coli 0.585874 0 0.60456 0 0 0.0471824 GO:0004176 ATP-dependent peptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.613459 1.5799 1.39239 0.716359 0.489531 1.12297 GO:0004177 aminopeptidase activity molecular_function Clostridium Clostridium thermocellum 6.52338 33.8588 27.6728 99.6169 87.4209 80.2233 GO:0004177 aminopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.3144 39.9123 41.5584 47.7174 50.0259 34.6273 GO:0004177 aminopeptidase activity molecular_function Escherichia Escherichia coli 0.194821 0 0.371315 0 0 0 GO:0004177 aminopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.110195 0.105762 0.102301 0.366511 0.196759 0.733058 GO:0004180 carboxypeptidase activity molecular_function Escherichia Escherichia coli 0.0897063 0 0 0 0 0.0341175 GO:0004181 metallocarboxypeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 33.8926 23.6485 24.7139 38.9734 42.7442 26.4803 GO:0004190 aspartic-type endopeptidase activity molecular_function Clostridium Clostridium thermocellum 21.8414 96.3971 62.0178 368.632 291.859 289.646 GO:0004190 aspartic-type endopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 104.23 59.6735 47.479 43.7817 52.6735 56.0565 GO:0004190 aspartic-type endopeptidase activity molecular_function Escherichia Escherichia coli 0.849645 0 0 0 0 0 GO:0004190 aspartic-type endopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.07835 1.61271 5.19237 1.59216 2.42495 1.77107 GO:0004222 metalloendopeptidase activity molecular_function Clostridium Clostridium thermocellum 15.874 79.6823 65.1974 234.733 226.917 228.067 GO:0004222 metalloendopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 280.168 233.463 295.625 157.125 171.002 163.369 GO:0004222 metalloendopeptidase activity molecular_function Escherichia Escherichia coli 0.29211 0 0.248852 0 0 0.0703371 GO:0004222 metalloendopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.15421 1.34845 1.12676 3.13577 0.79921 4.04883 GO:0004252 serine-type endopeptidase activity molecular_function Clostridium Clostridium thermocellum 32.0261 257.514 160.382 614.062 532.614 748.355 GO:0004252 serine-type endopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 495.191 371.733 627.56 174.649 233.427 174.943 GO:0004252 serine-type endopeptidase activity molecular_function Escherichia Escherichia coli 0.754325 0 0.272623 0 0 0.21971 GO:0004252 serine-type endopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.613459 2.02283 2.14688 0.923179 0.541379 1.27752 GO:0004298 threonine-type endopeptidase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0846632 GO:0004298 threonine-type endopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.790368 1.07172 0.82689 0.629488 0.217876 1.14874 GO:0004300 enoyl-CoA hydratase activity molecular_function Escherichia Escherichia coli 0.0966572 0 0 0 0 0.0158461 GO:0004309 exopolyphosphatase activity molecular_function Escherichia Escherichia coli 0.0349249 0 0.0648178 0 0 0 GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity molecular_function Clostridium Clostridium thermocellum 4.29596 11.3359 4.24667 85.2315 53.6559 45.0018 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity molecular_function Clostridium Clostridium thermocellum 13.9962 56.5422 38.7914 236.158 186.647 180.736 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 44.1284 22.1086 22.0817 16.7251 18.9639 12.4709 GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function Clostridium Clostridium thermocellum 2.86256 6.83302 2.50403 67.1869 44.9456 42.0939 GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 121.523 15.1214 19.827 18.5345 28.8193 18.2567 GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity molecular_function Escherichia Escherichia coli 0 0 0.150204 0 0 0 GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity molecular_function Clostridium Clostridium thermocellum 1.23664 9.73149 5.3981 27.9807 25.9851 38.4535 GO:0004322 ferroxidase activity molecular_function Escherichia Escherichia coli 0 0 0.27587 0 0 0.197785 GO:0004324 ferredoxin-NADP+ reductase activity molecular_function Escherichia Escherichia coli 0.0814186 0 0.453319 0 0 0 GO:0004325 ferrochelatase activity molecular_function Escherichia Escherichia coli 0.119552 0 0 0 0 0 GO:0004326 tetrahydrofolylpolyglutamate synthase activity molecular_function Clostridium Clostridium thermocellum 1.90938 12.2046 10.0561 43.7291 32.8488 33.8704 GO:0004326 tetrahydrofolylpolyglutamate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 76.9235 54.7017 38.7805 48.2917 49.3431 42.4473 GO:0004326 tetrahydrofolylpolyglutamate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.39985 0.994475 0.936498 0.632447 0.335809 0.891616 GO:0004329 formate-tetrahydrofolate ligase activity molecular_function Clostridium Clostridium thermocellum 2.90737 9.78498 7.73804 28.1126 23.9058 24.062 GO:0004329 formate-tetrahydrofolate ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 116.739 31.9796 72.7909 21.6495 34.3175 33.1361 GO:0004332 fructose-bisphosphate aldolase activity molecular_function Clostridium Clostridium thermocellum 9.251 187.596 131.683 467.604 448.693 467.214 GO:0004332 fructose-bisphosphate aldolase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 61.2687 66.3204 53.7575 64.3077 73.8739 48.3358 GO:0004332 fructose-bisphosphate aldolase activity molecular_function Escherichia Escherichia coli 0.0598123 0 0 0 0 0.0716306 GO:0004333 fumarate hydratase activity molecular_function Escherichia Escherichia coli 0 0 0.06784 0 0 0.042752 GO:0004337 geranyltranstransferase activity molecular_function Clostridium Clostridium thermocellum 2.70006 13.6808 8.69064 41.837 38.7719 33.1491 GO:0004337 geranyltranstransferase activity molecular_function Escherichia Escherichia coli 0.129589 0 0 0 0 0 GO:0004340 glucokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 31.7165 38.3485 36.1946 39.8729 59.346 47.8904 GO:0004340 glucokinase activity molecular_function Escherichia Escherichia coli 0.187263 0 0.404198 0 0 0 GO:0004342 glucosamine-6-phosphate deaminase activity molecular_function Escherichia Escherichia coli 0.244256 0 0 0 0 0.0564314 GO:0004345 glucose-6-phosphate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0366505 0 0.0680204 0 0 0 GO:0004347 glucose-6-phosphate isomerase activity molecular_function Clostridium Clostridium thermocellum 0.933883 12.0841 9.94279 33.4172 28.8943 27.7916 GO:0004347 glucose-6-phosphate isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 103.329 36.5149 39.0852 43.9878 53.5191 43.192 GO:0004348 glucosylceramidase activity molecular_function Clostridium Clostridium thermocellum 1.10134 2.62324 4.47595 5.63485 5.90085 6.5278 GO:0004349 glutamate 5-kinase activity molecular_function Clostridium Clostridium thermocellum 1.34997 13.8472 9.75601 30.13 25.187 30.716 GO:0004350 glutamate-5-semialdehyde dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 9.73207 35.5493 23.6101 77.5871 69.8801 71.8028 GO:0004351 glutamate decarboxylase activity molecular_function Escherichia Escherichia coli 0.27867 0 0 0 0 0.0517099 GO:0004352 glutamate dehydrogenase (NAD+) activity molecular_function Clostridium Clostridium thermocellum 4.32724 174.766 121.684 499.061 586.866 816.546 GO:0004353 glutamate dehydrogenase [NAD(P)+] activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.4938 24.2408 42.0628 7.5644 12.1989 20.408 GO:0004355 glutamate synthase (NADPH) activity molecular_function Clostridium Clostridium thermocellum 0.0358485 4.2676 11.7037 15.034 23.2169 30.3742 GO:0004355 glutamate synthase (NADPH) activity molecular_function Escherichia Escherichia coli 0.0766064 0 0 0 0 0 GO:0004355 glutamate synthase (NADPH) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.295076 0.463002 0.367572 1.10774 0.474339 0.297194 GO:0004356 glutamate-ammonia ligase activity molecular_function Clostridium Clostridium thermocellum 2.61341 25.5983 44.598 110.996 113.311 124.708 GO:0004356 glutamate-ammonia ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 89.8945 66.5803 94.2909 35.8416 41.9936 38.8995 GO:0004356 glutamate-ammonia ligase activity molecular_function Escherichia Escherichia coli 0.212272 0 0 0 0 0 GO:0004356 glutamate-ammonia ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.12344 0.0791584 0.229546 0.126465 0.0368081 0.164573 GO:0004357 glutamate-cysteine ligase activity molecular_function Escherichia Escherichia coli 0.0496775 0 0 0 0 0 GO:0004358 glutamate N-acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.01251 3.48787 2.17638 14.6388 12.8624 11.5721 GO:0004358 glutamate N-acetyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0917964 0.661038 0.553229 0.375812 0.122947 0.427488 GO:0004359 glutaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.81992 2.297 3.14567 4.0931 4.72397 2.14135 GO:0004359 glutaminase activity molecular_function Escherichia Escherichia coli 0.0933519 0 0 0 0 0 GO:0004359 glutaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.143807 1.02075 0.420797 1.67843 0.287976 1.1316 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity molecular_function Clostridium Clostridium thermocellum 2.87425 5.07356 2.99064 34.4445 23.9786 17.6544 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.418 12.2322 8.50232 16.6672 18.6474 15.7124 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity molecular_function Escherichia Escherichia coli 0.0289704 0 0 0 0 0 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.119795 0.431311 0.305731 0.612874 0.320878 0.91629 GO:0004362 glutathione-disulfide reductase activity molecular_function Escherichia Escherichia coli 0.0403933 0 0.0750119 0 0 0 GO:0004363 glutathione synthase activity molecular_function Escherichia Escherichia coli 0.0606872 0 0.338929 0 0 0 GO:0004364 glutathione transferase activity molecular_function Escherichia Escherichia coli 0.197665 0 0 0 0 0 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity molecular_function Clostridium Clostridium thermocellum 17.096 273.205 178.609 832.438 876.47 711.732 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 72.3995 272.804 209.82 182.612 265.605 187.264 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity molecular_function Escherichia Escherichia coli 0.114545 0 0 0 0 0 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.280858 0.37815 0.41764 0.143899 0.226014 0.823283 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity molecular_function Clostridium Clostridium thermocellum 1.81461 8.36484 5.49274 33.4607 32.5297 24.5134 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.221021 0.396106 0 0 GO:0004370 glycerol kinase activity molecular_function Clostridium Clostridium thermocellum 0.673538 4.71838 7.36433 1.45279 1.78719 2.7848 GO:0004370 glycerol kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0004371 glycerone kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 44.0015 40.5883 39.0635 39.6642 46.5421 34.0083 GO:0004371 glycerone kinase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0350877 GO:0004372 glycine hydroxymethyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.54412 52.7806 35.9423 179.599 189.141 149.235 GO:0004372 glycine hydroxymethyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.6804 11.9841 12.0337 8.85192 9.73997 6.94814 GO:0004372 glycine hydroxymethyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.106889 0.164198 0.236042 0.436595 0.0381754 0.0853423 GO:0004373 glycogen (starch) synthase activity molecular_function Clostridium Clostridium thermocellum 3.25983 22.9129 16.1641 176.137 163.855 141.991 GO:0004373 glycogen (starch) synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 25.1303 18.9059 16.8647 23.5169 27.9081 19.338 GO:0004373 glycogen (starch) synthase activity molecular_function Escherichia Escherichia coli 0.0567743 0 0 0 0 0 GO:0004375 glycine dehydrogenase (decarboxylating) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 476.331 101.139 151.15 106.948 128.231 86.6769 GO:0004385 guanylate kinase activity molecular_function Clostridium Clostridium thermocellum 6.36256 43.2792 39.5261 90.7204 102.094 88.9995 GO:0004385 guanylate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.54212 5.69572 8.38789 2.93569 5.3372 3.63437 GO:0004386 helicase activity molecular_function Clostridium Clostridium thermocellum 25.7281 56.9332 61.8204 146.024 134.366 154.195 GO:0004386 helicase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 105.601 85.1105 86.6728 103.951 114.248 58.8483 GO:0004386 helicase activity molecular_function Escherichia Escherichia coli 0.155279 0 0.0812816 0 0 0 GO:0004386 helicase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.695193 1.11107 0.67001 0.69517 0.403913 0.703759 GO:0004399 histidinol dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 6.8615 3.66701 2.49149 5.92521 5.05713 9.77171 GO:0004399 histidinol dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0420946 0 0 0 0 0 GO:0004399 histidinol dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0644787 0 0.079748 0.0879905 0.0191854 0.257353 GO:0004400 histidinol-phosphate transaminase activity molecular_function Clostridium Clostridium thermocellum 4.56046 1.96286 3.3081 6.08756 5.57112 11.4018 GO:0004400 histidinol-phosphate transaminase activity molecular_function Escherichia Escherichia coli 0.0263942 0 0 0 0 0 GO:0004400 histidinol-phosphate transaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0750023 0 0 0.204656 0.13395 0 GO:0004401 histidinol-phosphatase activity molecular_function Clostridium Clostridium thermocellum 0.225031 10.0075 4.38492 23.3951 23.3628 20.5036 GO:0004401 histidinol-phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.5271 7.66759 4.65114 5.86783 5.8383 4.92968 GO:0004401 histidinol-phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0704018 GO:0004410 homocitrate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.18198 0.0879123 0.242384 0.0846197 0 GO:0004412 homoserine dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 2.21332 13.9762 11.2052 43.3594 50.9134 49.5504 GO:0004412 homoserine dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0420217 0 0.0395132 0 0 0 GO:0004412 homoserine dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.55282 0.38025 0.620257 0.26907 0.176814 0.670288 GO:0004413 homoserine kinase activity molecular_function Escherichia Escherichia coli 0 0 0.115202 0 0 0 GO:0004414 homoserine O-acetyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.120013 0.40284 0.333381 0.368252 0 0.239502 GO:0004416 hydroxyacylglutathione hydrolase activity molecular_function Escherichia Escherichia coli 0.226611 0 0.148851 0 0 0 GO:0004417 hydroxyethylthiazole kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0366505 0.0703838 0 0.0750332 0 0 GO:0004418 hydroxymethylbilane synthase activity molecular_function Clostridium Clostridium thermocellum 0.233319 3.13586 4.32944 6.23263 4.85062 5.67706 GO:0004418 hydroxymethylbilane synthase activity molecular_function Escherichia Escherichia coli 0.0613677 0 0.0569693 0 0 0 GO:0004418 hydroxymethylbilane synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.129659 0 0.241738 0.241185 0.26948 GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0465666 0.357427 0 0.0476512 0.12349 0.0309807 GO:0004421 hydroxymethylglutaryl-CoA synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.189037 0.259319 0 0.193415 0.192787 0.215506 GO:0004422 hypoxanthine phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.33922 13.577 10.8916 51.0264 39.3707 68.6689 GO:0004422 hypoxanthine phosphoribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.76042 9.12357 11.0711 12.0851 15.1185 13.2017 GO:0004422 hypoxanthine phosphoribosyltransferase activity molecular_function Escherichia Escherichia coli 0.125603 0 0.23311 0 0 0.309904 GO:0004422 hypoxanthine phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.634761 0.307761 0.0564054 0.0984227 0 GO:0004424 imidazoleglycerol-phosphate dehydratase activity molecular_function Clostridium Clostridium thermocellum 4.49285 14.2685 9.9759 44.5942 43.9294 63.3729 GO:0004424 imidazoleglycerol-phosphate dehydratase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0704018 GO:0004424 imidazoleglycerol-phosphate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.121538 0 0.452213 0 0.414617 GO:0004425 indole-3-glycerol-phosphate synthase activity molecular_function Clostridium Clostridium thermocellum 2.57266 24.0192 61.392 115.516 61.6443 41.812 GO:0004425 indole-3-glycerol-phosphate synthase activity molecular_function Escherichia Escherichia coli 0.0401989 0 0.403341 0 0 0 GO:0004425 indole-3-glycerol-phosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.254245 0 0 0.297397 0.0648917 0.0966933 GO:0004427 inorganic diphosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 350.8 83.2577 135.248 37.9121 46.7459 53.6946 GO:0004427 inorganic diphosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.122518 0 0.19547900000000001 0.170889 0.169747 GO:0004450 isocitrate dehydrogenase (NADP+) activity molecular_function Clostridium Clostridium thermocellum 2.4552 47.411 32.8214 119.773 121.21 121.8 GO:0004450 isocitrate dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0.301249 0 0 0 0 0 GO:0004452 isopentenyl-diphosphate delta-isomerase activity molecular_function Escherichia Escherichia coli 0.121836 0 0 0 0 0 GO:0004452 isopentenyl-diphosphate delta-isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.440599 0 0.071857 GO:0004455 ketol-acid reductoisomerase activity molecular_function Clostridium Clostridium thermocellum 5.22625 45.7734 22.807 155.133 139.625 109.7 GO:0004455 ketol-acid reductoisomerase activity molecular_function Escherichia Escherichia coli 0.0916506 0 0 0 0 0 GO:0004455 ketol-acid reductoisomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.256699 0.273834 0.529368 0.640953 0.433017 0.719961 GO:0004457 lactate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.048681 0 0 0 0 0 GO:0004459 L-lactate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 3.46493 69.7876 42.5249 207.81 224.645 241.768 GO:0004462 lactoylglutathione lyase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.198108 GO:0004467 long-chain fatty acid-CoA ligase activity molecular_function Clostridium Clostridium thermocellum 1.50654 10.064 9.61261 31.4217 29.0526 26.3609 GO:0004467 long-chain fatty acid-CoA ligase activity molecular_function Escherichia Escherichia coli 0.0334181 0 0 0 0 0 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function Clostridium Clostridium thermocellum 3.60944 42.0489 25.6481 168.701 165.262 118.091 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.7036 8.48671 7.60015 8.90226 8.78091 8.77558 GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity molecular_function Escherichia Escherichia coli 0.0541008 0 0 0 0 0 GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity molecular_function Escherichia Escherichia coli 0.0227 0 0 0 0 0 GO:0004474 malate synthase activity molecular_function Escherichia Escherichia coli 0.18194 0 0 0 0 0.0160078 GO:0004476 mannose-6-phosphate isomerase activity molecular_function Clostridium Clostridium thermocellum 0.206414 1.43657 1.96276 1.34644 1.35921 2.50581 GO:0004476 mannose-6-phosphate isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 103.329 36.5149 39.0852 43.9878 53.5191 43.192 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity molecular_function Clostridium Clostridium thermocellum 3.36373 25.4413 20.4405 67.1305 69.6195 82.2671 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 19.6246 15.6943 13.5065 11.7277 13.4742 12.471 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity molecular_function Escherichia Escherichia coli 0.0648918 0 0 0 0 0 GO:0004478 methionine adenosyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.44273 25.2447 17.4504 80.409 108.614 87.4991 GO:0004478 methionine adenosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 27.8182 10.2815 7.51373 26.666 34.968 18.8696 GO:0004478 methionine adenosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.13462 0.215492 0.0833114 0.183691 0.320661 0.298617 GO:0004479 methionyl-tRNA formyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.67234 8.05829 3.97437 21.9495 25.1216 21.5837 GO:0004479 methionyl-tRNA formyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.0495 2.86697 1.65089 4.64895 5.52834 3.92817 GO:0004479 methionyl-tRNA formyltransferase activity molecular_function Escherichia Escherichia coli 0.030453 0 0 0 0 0 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity molecular_function Clostridium Clostridium thermocellum 3.36373 25.4413 20.4405 67.1305 69.6195 82.2671 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.1493 7.35935 4.96675 6.47417 8.13417 6.97611 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0.0648918 0 0 0 0 0 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function Clostridium Clostridium thermocellum 1.57845 10.2468 7.60732 23.8811 24.2439 32.6953 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.722657 0.346785 0.335366 0.154046 0.484084 0.24044 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity molecular_function Escherichia Escherichia coli 0.0654265 0 0.365136 0 0 0 GO:0004492 methylmalonyl-CoA decarboxylase activity molecular_function Escherichia Escherichia coli 0.0764362 0 0 0 0 0 GO:0004493 methylmalonyl-CoA epimerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.3162 8.23365 8.48653 14.4089 14.1878 7.84829 GO:0004494 methylmalonyl-CoA mutase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 36.169 30.2736 36.8775 35.6744 41.2843 29.5255 GO:0004494 methylmalonyl-CoA mutase activity molecular_function Escherichia Escherichia coli 0.024377 0 0 0 0 0 GO:0004496 mevalonate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0638711 0 0 0.0326296 0.0569702 0 GO:0004497 monooxygenase activity molecular_function Escherichia Escherichia coli 0.0551702 0 0 0 0 0 GO:0004512 inositol-3-phosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.152362 0.292504 0.471046 1.14353 0.702936 2.02296 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity molecular_function Clostridium Clostridium thermocellum 2.85405 9.54247 7.30985 28.0832 25.783 21.5468 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 89.3657 60.1381 85.4022 59.323 66.2923 35.4696 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity molecular_function Escherichia Escherichia coli 0.111507 0 0 0 0 0.0614116 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.140891 0.270474 1.04566 0.79286 0.597525 1.31196 GO:0004515 nicotinate-nucleotide adenylyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.34085 20.9829 21.6321 36.9281 37.2437 53.7562 GO:0004515 nicotinate-nucleotide adenylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.82436 1.08143 1.04268 1.66978 1.50679 0.969682 GO:0004516 nicotinate phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.5758 3.20363 4.54108 9.51954 9.20165 8.45937 GO:0004516 nicotinate phosphoribosyltransferase activity molecular_function Escherichia Escherichia coli 0.0461534 0 0 0 0 0.0614116 GO:0004518 nuclease activity molecular_function Clostridium Clostridium thermocellum 21.0796 51.9369 34.9582 173.701 134.793 129.926 GO:0004518 nuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 55.8066 40.5733 20.8201 50.4157 46.4035 50.3637 GO:0004518 nuclease activity molecular_function Escherichia Escherichia coli 0.098796 0 0 0 0 0.131458 GO:0004518 nuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.387917 0.820709 0.32427 0.874657 0.261824 0.506459 GO:0004519 endonuclease activity molecular_function Clostridium Clostridium thermocellum 17.8288 128.05 87.0348 232.783 205.035 246.972 GO:0004519 endonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.5659 32.7569 26.7187 28.7994 36.2562 27.7007 GO:0004519 endonuclease activity molecular_function Escherichia Escherichia coli 14.215 0 19.0134 0 0 14.9181 GO:0004519 endonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.507712 4.05309 2.5444 1.32391 1.07866 1.98554 GO:0004520 endodeoxyribonuclease activity molecular_function Escherichia Escherichia coli 0.117413 0 0 0 0 0 GO:0004521 endoribonuclease activity molecular_function Clostridium Clostridium thermocellum 32.7334 113.255 88.1507 348.974 329.816 293.132 GO:0004521 endoribonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.6697 20.4772 24.8957 11.9362 18.021 18.0653 GO:0004521 endoribonuclease activity molecular_function Escherichia Escherichia coli 1.1593 0 0.234914 0 0 0.336874 GO:0004521 endoribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.385778 0.370448 0.358009 0 0.694624 0 GO:0004523 RNA-DNA hybrid ribonuclease activity molecular_function Clostridium Clostridium thermocellum 6.60254 42.4215 39.2954 125.812 115.846 91.043 GO:0004523 RNA-DNA hybrid ribonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.3696 16.8787 7.154 15.0504 17.1981 11.483 GO:0004523 RNA-DNA hybrid ribonuclease activity molecular_function Escherichia Escherichia coli 0.108736 0 0 0 0 0 GO:0004523 RNA-DNA hybrid ribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.102879 0.197149 0.286516 0.686316 0.23029 0.411803 GO:0004525 ribonuclease III activity molecular_function Clostridium Clostridium thermocellum 4.14681 40.0227 24.6458 88.8496 77.3832 115.279 GO:0004526 ribonuclease P activity molecular_function Clostridium Clostridium thermocellum 7.86346 63.3051 50.074 182.415 160.09 200.806 GO:0004526 ribonuclease P activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.77181 3.4195 3.27675 5.62935 1.25308 8.58045 GO:0004527 exonuclease activity molecular_function Clostridium Clostridium thermocellum 0.786552 4.32842 5.81313 17.9185 10.1795 12.5853 GO:0004527 exonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.5885 34.9914 35.9408 31.3281 39.4867 21.3861 GO:0004527 exonuclease activity molecular_function Escherichia Escherichia coli 0.0798631 0 0.0179072 0 0 0.0256771 GO:0004527 exonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.40476 1.41314 0.770146 1.8231 0.971466 5.41185 GO:0004530 deoxyribonuclease I activity molecular_function Escherichia Escherichia coli 0.0871057 0 0 0 0 0.0579513 GO:0004534 5'-3' exoribonuclease activity molecular_function Clostridium Clostridium thermocellum 0.768105 10.3592 7.48738 30.4662 30.5283 29.2001 GO:0004534 5'-3' exoribonuclease activity molecular_function Escherichia Escherichia coli 0 0 0.116555 0 0 0.0883498 GO:0004540 ribonuclease activity molecular_function Clostridium Clostridium thermocellum 3.60021 22.6071 16.4999 76.4092 73.2016 75.4608 GO:0004540 ribonuclease activity molecular_function Escherichia Escherichia coli 0.109563 0 0 0 0 0.0979868 GO:0004540 ribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0 0.1767 GO:0004549 tRNA-specific ribonuclease activity molecular_function Clostridium Clostridium thermocellum 3.09874 22.0906 19.5707 49.8565 44.7456 41.7264 GO:0004549 tRNA-specific ribonuclease activity molecular_function Escherichia Escherichia coli 0.171465 0 0 0 0 0 GO:0004550 nucleoside diphosphate kinase activity molecular_function Clostridium Clostridium thermocellum 1.86167 12.8491 11.2268 58.815 46.6577 64.3269 GO:0004550 nucleoside diphosphate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 161.758 282.441 228.356 175.603 195.079 248.125 GO:0004550 nucleoside diphosphate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.396861 0.152529 0.883498 0.485838 0.638087 0.949793 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function Clostridium Clostridium thermocellum 243.578 426.5 408.561 1146.64 1087.85 1158.79 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.3339 38.3753 20.3505 25.8515 35.8054 29.1819 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds molecular_function Escherichia Escherichia coli 1.51076 0 2.38798 0 0 0.0514188 GO:0004555 alpha,alpha-trehalase activity molecular_function Escherichia Escherichia coli 0.0972162 0 0.222825 0 0 0 GO:0004556 alpha-amylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 101.997 40.8794 52.5729 38.4827 41.8009 33.3908 GO:0004556 alpha-amylase activity molecular_function Escherichia Escherichia coli 0.104191 0 0.0487149 0 0 0 GO:0004557 alpha-galactosidase activity molecular_function Escherichia Escherichia coli 0.0402961 0 0 0 0 0 GO:0004558 alpha-1,4-glucosidase activity molecular_function Escherichia Escherichia coli 0.016867 0 0 0 0 0 GO:0004559 alpha-mannosidase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0327593 GO:0004563 beta-N-acetylhexosaminidase activity molecular_function Clostridium Clostridium thermocellum 0.287104 1.96897 0.493599 4.28 4.08377 5.26529 GO:0004563 beta-N-acetylhexosaminidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.15682 0.18156 0 0.0484221 0.16874 0 GO:0004563 beta-N-acetylhexosaminidase activity molecular_function Escherichia Escherichia coli 0.0554862 0 0 0 0 0 GO:0004565 beta-galactosidase activity molecular_function Escherichia Escherichia coli 2179.04 0 768.067 0 0 225.731 GO:0004568 chitinase activity molecular_function Clostridium Clostridium thermocellum 5.29947 8.80582 9.09723 23.3712 19.9315 20.0054 GO:0004576 oligosaccharyl transferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.228774 0.391592 0.231305 0.153225 0.327671 0.202312 GO:0004585 ornithine carbamoyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.50707 2.58642 1.39825 7.4204 5.77356 4.76255 GO:0004585 ornithine carbamoyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 51.7953 16.3761 20.4556 20.6356 23.7289 14.788 GO:0004585 ornithine carbamoyltransferase activity molecular_function Escherichia Escherichia coli 0.05675 0 0.0494366 0 0 0 GO:0004585 ornithine carbamoyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.28934 0.24695 0.715838 0.19739399999999999 0.258373 0.598884 GO:0004586 ornithine decarboxylase activity molecular_function Escherichia Escherichia coli 0.0726691 0 0.0220119 0 0 0 GO:0004588 orotate phosphoribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.1579 4.68626 2.36768 1.02219 2.77335 2.067 GO:0004588 orotate phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.41646 2.8497 2.17534 1.8344 1.60022 1.31639 GO:0004589 orotate reductase (NADH) activity molecular_function Clostridium Clostridium thermocellum 0.785021 5.36028 4.36413 21.353 15.7481 14.4096 GO:0004589 orotate reductase (NADH) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.159386 0.122518 0.118404 0.195778 0.113897 0.0848896 GO:0004590 orotidine-5'-phosphate decarboxylase activity molecular_function Clostridium Clostridium thermocellum 0.427873 3.69296 2.61121 7.47407 12.7419 11.5439 GO:0004590 orotidine-5'-phosphate decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.65496 0.502161 1.29126 0.534832 0.505483 0.811253 GO:0004590 orotidine-5'-phosphate decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.226417 0.346785 0.0842136 0.835562 0.283353 0.512798 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity molecular_function Escherichia Escherichia coli 0.00916263 0 0 0 0 0 GO:0004592 pantoate-beta-alanine ligase activity molecular_function Clostridium Clostridium thermocellum 4.14834 22.4429 12.4929 47.0788 46.2156 50.0343 GO:0004592 pantoate-beta-alanine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 28.1785 13.5293 17.686 16.3655 18.0141 13.8987 GO:0004592 pantoate-beta-alanine ligase activity molecular_function Escherichia Escherichia coli 0.0692422 0 0 0 0 0 GO:0004594 pantothenate kinase activity molecular_function Clostridium Clostridium thermocellum 14.6644 93.1317 77.7649 208.36 193.382 177.128 GO:0004594 pantothenate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 18.5659 13.794 9.32691 14.7015 16.0576 10.3332 GO:0004594 pantothenate kinase activity molecular_function Escherichia Escherichia coli 0.125117 0 0 0 0 0 GO:0004595 pantetheine-phosphate adenylyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.35608 26.1485 22.2304 65.138 64.5237 83.1103 GO:0004595 pantetheine-phosphate adenylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.4902 56.2534 48.499 34.4354 37.4669 34.461 GO:0004595 pantetheine-phosphate adenylyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.681377 0 0 0 GO:0004595 pantetheine-phosphate adenylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.127512 0.246461 0.407348 0.0592924 0.264823 GO:0004596 peptide alpha-N-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.0736413 0 0.135454 0 0 0 GO:0004601 peroxidase activity molecular_function Clostridium Clostridium thermocellum 22.6348 216.426 161.484 605.149 432.637 705.98 GO:0004601 peroxidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 260.486 574.494 494.362 378.685 526.602 516.122 GO:0004601 peroxidase activity molecular_function Escherichia Escherichia coli 0.313036 0 0.211143 0 0 0 GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity molecular_function Clostridium Clostridium thermocellum 0.170566 28.8948 17.7178 62.1958 54.7957 58.7528 GO:0004605 phosphatidate cytidylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 38.6834 30.7983 30.6151 37.2582 38.9489 27.505 GO:0004605 phosphatidate cytidylyltransferase activity molecular_function Escherichia Escherichia coli 0.323463 0 0 0 0 0 GO:0004609 phosphatidylserine decarboxylase activity molecular_function Escherichia Escherichia coli 0.0296752 0 0 0 0 0 GO:0004609 phosphatidylserine decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.35766 0.172802 0.19058 0.415611 0.803427 GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 189.884 47.5127 106.482 7.40456 7.98654 10.4351 GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity molecular_function Escherichia Escherichia coli 0.0745648 0 0 0 0 0.0216994 GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity molecular_function Clostridium Clostridium thermocellum 3.81639 65.064 74.5875 230.114 193.526 182.721 GO:0004614 phosphoglucomutase activity molecular_function Clostridium Clostridium thermocellum 4.60829 38.8424 31.8566 98.9275 100.38 84.5695 GO:0004615 phosphomannomutase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.8829 23.3093 38.9594 16.8403 20.9545 17.0455 GO:0004615 phosphomannomutase activity molecular_function Escherichia Escherichia coli 0.03981 0 0 0 0 0 GO:0004615 phosphomannomutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.219466 0.306412 0.222149 0.38785 0.213665 0.132719 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity molecular_function Escherichia Escherichia coli 0.128496 0 0.118855 0 0 0 GO:0004617 phosphoglycerate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0224326 0 0 0 0 0 GO:0004617 phosphoglycerate dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.03405 0.326855 0.126027 0.191276 0.334051 0.724488 GO:0004618 phosphoglycerate kinase activity molecular_function Clostridium Clostridium thermocellum 3.79131 58.1847 51.2642 168.02 174.865 180.172 GO:0004618 phosphoglycerate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 111.779 217.204 256.907 182.841 228.413 77.4405 GO:0004618 phosphoglycerate kinase activity molecular_function Escherichia Escherichia coli 0.0239638 0 0 0 0 0 GO:0004618 phosphoglycerate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.604126 0.472757 0.498245 0.847126 0.139897 0.387129 GO:0004619 phosphoglycerate mutase activity molecular_function Escherichia Escherichia coli 0.0757071 0 0 0 0 0 GO:0004622 lysophospholipase activity molecular_function Escherichia Escherichia coli 0.0556806 0 0 0 0 0 GO:0004632 phosphopantothenate--cysteine ligase activity molecular_function Clostridium Clostridium thermocellum 2.40399 14.0103 9.51189 35.0685 35.422 28.2307 GO:0004632 phosphopantothenate--cysteine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.75624 4.16977 2.89714 3.77369 4.86838 3.58089 GO:0004632 phosphopantothenate--cysteine ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.144245 0.461509 0.356881 0.318537 0.0643926 0.383798 GO:0004633 phosphopantothenoylcysteine decarboxylase activity molecular_function Clostridium Clostridium thermocellum 2.40399 14.0103 9.51189 35.0685 35.422 28.2307 GO:0004633 phosphopantothenoylcysteine decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.75624 4.16977 2.89714 3.77369 4.86838 3.58089 GO:0004633 phosphopantothenoylcysteine decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.144245 0.461509 0.356881 0.318537 0.0643926 0.383798 GO:0004634 phosphopyruvate hydratase activity molecular_function Clostridium Clostridium thermocellum 3.85773 22.1513 21.5629 82.9536 74.2882 59.5495 GO:0004634 phosphopyruvate hydratase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 45.8416 44.4224 44.6618 63.8743 66.3513 33.0344 GO:0004634 phosphopyruvate hydratase activity molecular_function Escherichia Escherichia coli 0.0423134 0 0 0 0 0 GO:0004634 phosphopyruvate hydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0882966 0.0847593 0.245785 0.20289 0.137987 0.117487 GO:0004635 phosphoribosyl-AMP cyclohydrolase activity molecular_function Clostridium Clostridium thermocellum 5.16145 12.643 7.12207 41.9038 37.3034 32.0724 GO:0004635 phosphoribosyl-AMP cyclohydrolase activity molecular_function Escherichia Escherichia coli 0.105553 0 0 0 0 0 GO:0004635 phosphoribosyl-AMP cyclohydrolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.523771 0 0.744487 0.402264 0.484469 GO:0004636 phosphoribosyl-ATP diphosphatase activity molecular_function Clostridium Clostridium thermocellum 5.16145 12.643 7.12207 41.9038 37.3034 32.0724 GO:0004636 phosphoribosyl-ATP diphosphatase activity molecular_function Escherichia Escherichia coli 0.105553 0 0 0 0 0 GO:0004636 phosphoribosyl-ATP diphosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.344729 0 0 0.176379 0 0 GO:0004637 phosphoribosylamine-glycine ligase activity molecular_function Clostridium Clostridium thermocellum 2.01403 3.10991 2.39668 42.2397 25.3504 20.3035 GO:0004637 phosphoribosylamine-glycine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.218907 0.0841058 0.325081 0.156781 0.136663 0.116549 GO:0004637 phosphoribosylamine-glycine ligase activity molecular_function Escherichia Escherichia coli 0.149227 0 0 0 0 0 GO:0004637 phosphoribosylamine-glycine ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0992578 0.190708 0.662883 0.446991 0.265904 0.554806 GO:0004638 phosphoribosylaminoimidazole carboxylase activity molecular_function Escherichia Escherichia coli 0.0529585 0 0.0982867 0 0 0 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity molecular_function Clostridium Clostridium thermocellum 5.4872 26.5875 18.6503 57.3266 73.4186 83.0339 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.8198 8.56666 8.91942 10.4106 14.3067 6.56819 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity molecular_function Escherichia Escherichia coli 0.0430911 0 0 0 0 0 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.312713 0 0.0832403 0.0727048 0 GO:0004640 phosphoribosylanthranilate isomerase activity molecular_function Clostridium Clostridium thermocellum 18.6339 91.8732 205.184 213.941 99.8994 113.607 GO:0004640 phosphoribosylanthranilate isomerase activity molecular_function Escherichia Escherichia coli 0.0401989 0 0.403341 0 0 0 GO:0004640 phosphoribosylanthranilate isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.337267 0 0 0.215898 0 0.449058 GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity molecular_function Clostridium Clostridium thermocellum 3.17338 8.07094 4.4925 73.8931 64.9073 47.4268 GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.168184 0 0 0.114751 0 0.149147 GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity molecular_function Escherichia Escherichia coli 0.0273664 0 0 0 0 0 GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.0538147 0 0.172101 0 0.223785 GO:0004642 phosphoribosylformylglycinamidine synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 40.0243 24.5918 29.3687 38.3741 50.1104 39.1429 GO:0004642 phosphoribosylformylglycinamidine synthase activity molecular_function Escherichia Escherichia coli 0.00651349 0 0 0 0 0 GO:0004642 phosphoribosylformylglycinamidine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.436088 2.51687 2.98446 0.386432 0.335809 0.664144 GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.53247 2.87719 2.16578 36.1461 27.8234 16.8718 GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0520107 0 0 0 0 0 GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity molecular_function Escherichia Escherichia coli 0.0337826 0 0 0 0 0 GO:0004644 phosphoribosylglycinamide formyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.68215 4.85765 2.25058 51.3108 40.3012 35.0655 GO:0004644 phosphoribosylglycinamide formyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.26297 0 0 0.124181 GO:0004645 phosphorylase activity molecular_function Clostridium Clostridium thermocellum 0.738284 1.98489 2.77977 9.99093 9.33907 7.15631 GO:0004645 phosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 30.5868 22.757 25.5162 24.0789 31.9322 18.0353 GO:0004645 phosphorylase activity molecular_function Escherichia Escherichia coli 0.0414384 0 0 0 0 0 GO:0004647 phosphoserine phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.11015 0 0 0.114674 GO:0004647 phosphoserine phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.145095 0.348792 0.269691 0.260216 0.388699 0.338362 GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity molecular_function Clostridium Clostridium thermocellum 3.83627 38.8084 29.9703 82.1011 81.3638 64.717 GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity molecular_function Escherichia Escherichia coli 0 0 0.0959863 0 0 0 GO:0004652 polynucleotide adenylyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.0742451 0 0 0 GO:0004654 polyribonucleotide nucleotidyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.72492 16.2016 15.1478 61.5467 63.3508 61.82 GO:0004654 polyribonucleotide nucleotidyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.5488 53.4827 41.7801 34.7674 39.6371 35.03 GO:0004655 porphobilinogen synthase activity molecular_function Clostridium Clostridium thermocellum 0.116975 17.2936 10.5792 18.964 18.7113 28.8204 GO:0004655 porphobilinogen synthase activity molecular_function Escherichia Escherichia coli 0.0294565 0 0.109338 0 0 0 GO:0004655 porphobilinogen synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.434058 0 0.0522389 0.311359 GO:0004657 proline dehydrogenase activity molecular_function Escherichia Escherichia coli 0.00636766 0 0 0 0 0 GO:0004658 propionyl-CoA carboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.7308 24.1489 20.9167 25.6852 28.76 20.2805 GO:0004659 prenyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.82448 14.6845 12.1855 34.2103 30.4807 42.2707 GO:0004659 prenyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 55.5829 45.2354 39.5043 26.6307 28.8053 32.1429 GO:0004659 prenyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.507663 0.578939 0.791662 0.65687 0.990868 0.760384 GO:0004664 prephenate dehydratase activity molecular_function Clostridium Clostridium thermocellum 1.98005 18.4487 13.3233 48.5815 38.0421 46.1078 GO:0004664 prephenate dehydratase activity molecular_function Escherichia Escherichia coli 0.0721101 0 0 0 0 0 GO:0004664 prephenate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0861822 0 0 0.176379 0 0 GO:0004665 prephenate dehydrogenase (NADP+) activity molecular_function Clostridium Clostridium thermocellum 3.38371 16.3874 12.5114 61.2005 62.8299 58.0045 GO:0004665 prephenate dehydrogenase (NADP+) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.2427 0.544541 0.41349 0.496905 0.289343 0.565963 GO:0004672 protein kinase activity molecular_function Clostridium Clostridium thermocellum 7.45145 125.108 181.324 120.968 133.784 130.793 GO:0004672 protein kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 75.0917 139.048 107.562 77.1771 113.396 139.174 GO:0004672 protein kinase activity molecular_function Escherichia Escherichia coli 0.251012 0 0.111052 0 0 0 GO:0004672 protein kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.174041 0.243076 0 0.0485714 0.0282572 0.294187 GO:0004673 protein histidine kinase activity molecular_function Clostridium Clostridium thermocellum 6.39588 71.5724 51.717 237.038 215.67 195.354 GO:0004673 protein histidine kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.7059 37.7065 30.1439 26.8137 59.6813 43.0816 GO:0004673 protein histidine kinase activity molecular_function Escherichia Escherichia coli 0 0 0.287237 0 0 0.103032 GO:0004674 protein serine/threonine kinase activity molecular_function Clostridium Clostridium thermocellum 6.96112 35.6461 30.2686 102.969 97.4742 102.245 GO:0004674 protein serine/threonine kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.3533 25.4559 20.4179 24.5232 34.2803 29.4076 GO:0004674 protein serine/threonine kinase activity molecular_function Escherichia Escherichia coli 0.356686 0 0.056834 0 0 0.0409087 GO:0004674 protein serine/threonine kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.595862 0.470283 0.297116 0.691986 0.566707 0.558299 GO:0004683 calmodulin-dependent protein kinase activity molecular_function Clostridium Clostridium thermocellum 0.0556077 0 0 0 0 0.0246746 GO:0004712 protein serine/threonine/tyrosine kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.116927 0.192435 0.0620212 0.136711 0.178984 0.0888996 GO:0004713 protein tyrosine kinase activity molecular_function Escherichia Escherichia coli 0.0241339 0 0.0892204 0 0 0 GO:0004715 non-membrane spanning protein tyrosine kinase activity molecular_function Clostridium Clostridium thermocellum 0.0810054 0.0778049 0.150339 0.41451 0.434058 1.2931 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity molecular_function Escherichia Escherichia coli 0.150126 0 0 0 0 0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0482192 0 0.714034 0.19739399999999999 0.0430586 0 GO:0004721 phosphoprotein phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 25.0964 43.7269 34.3691 34.0487 43.6273 31.819 GO:0004721 phosphoprotein phosphatase activity molecular_function Escherichia Escherichia coli 0.472714 0 0.234779 0 0 0.0409087 GO:0004722 protein serine/threonine phosphatase activity molecular_function Clostridium Clostridium thermocellum 4.93647 29.9201 30.9732 87.7261 84.643 86.1459 GO:0004722 protein serine/threonine phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.3109 17.9195 22.4086 8.36427 10.611 10.9722 GO:0004725 protein tyrosine phosphatase activity molecular_function Clostridium Clostridium thermocellum 19.3853 70.367 65.5947 78.3262 101.396 112.694 GO:0004725 protein tyrosine phosphatase activity molecular_function Escherichia Escherichia coli 0.0208286 0 0 0 0 0 GO:0004725 protein tyrosine phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.399656 0 0 0 0 0.266149 GO:0004730 pseudouridylate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.07992 3.38192 3.26796 1.73579 2.60042 1.87404 GO:0004730 pseudouridylate synthase activity molecular_function Escherichia Escherichia coli 0.0620482 0 0 0 0 0 GO:0004731 purine-nucleoside phosphorylase activity molecular_function Clostridium Clostridium thermocellum 1.72022 18.1692 10.3778 43.6338 44.313 48.9259 GO:0004731 purine-nucleoside phosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 28.585 20.7275 25.3295 20.3184 29.3266 23.5188 GO:0004731 purine-nucleoside phosphorylase activity molecular_function Escherichia Escherichia coli 0.0852829 0 0 0 0 0 GO:0004733 pyridoxamine-phosphate oxidase activity molecular_function Clostridium Clostridium thermocellum 5.39805 60.7914 55.4234 115.168 118.371 180.87 GO:0004733 pyridoxamine-phosphate oxidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.502021 0.371225 0.753639 1.08491 1.39115 GO:0004735 pyrroline-5-carboxylate reductase activity molecular_function Clostridium Clostridium thermocellum 2.59103 20.7372 19.3588 49.6324 43.152 37.7646 GO:0004735 pyrroline-5-carboxylate reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0397128 0 0.147272 0.162477 0.0709251 0.158525 GO:0004736 pyruvate carboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.75758 6.23732 5.74456 5.50612 6.79375 4.79741 GO:0004736 pyruvate carboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.214483 0.324848 0.387915 0.422295 0.22851 0.521044 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.98204 0 0 0.176379 0.10259 0 GO:0004743 pyruvate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 82.4715 172.006 221.728 91.3702 114.013 90.918 GO:0004746 riboflavin synthase activity molecular_function Clostridium Clostridium thermocellum 1.34139 12.9787 6.66893 25.5426 23.7845 18.0357 GO:0004746 riboflavin synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.448767 0.289132 0.637695 0.277797 0.829201 GO:0004747 ribokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.484137 1.66564 2.81522 0.0990826 0.4323 1.37424 GO:0004747 ribokinase activity molecular_function Escherichia Escherichia coli 0.276264 0 0 0 0 0.0783571 GO:0004747 ribokinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.10464 0.913123 0.976913 1.40999 0.602386 1.25934 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function Clostridium Clostridium thermocellum 4.8596 35.6615 27.4644 44.2686 37.3282 32.9128 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 43.4601 12.68 12.8797 12.3158 13.8459 8.77247 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function Escherichia Escherichia coli 0.17861 0 0.200498 0 0 0.0329857 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0743218 0 0.137935 0 0.055299 0.0494138 GO:0004749 ribose phosphate diphosphokinase activity molecular_function Clostridium Clostridium thermocellum 7.68042 47.456 38.0977 129.847 130.084 128.96 GO:0004749 ribose phosphate diphosphokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 18.0708 16.0209 9.62597 23.7424 27.9475 19.6547 GO:0004749 ribose phosphate diphosphokinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0685617 0.395372 0.191116 0.56194 0.0306445 0.548177 GO:0004750 ribulose-phosphate 3-epimerase activity molecular_function Clostridium Clostridium thermocellum 1.37374 14.2688 7.56172 54.0517 42.5857 66.3568 GO:0004750 ribulose-phosphate 3-epimerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.83739 2.90795 0.790128 2.32528 3.97537 4.41161 GO:0004750 ribulose-phosphate 3-epimerase activity molecular_function Escherichia Escherichia coli 0.180992 0 0.0933701 0 0 0.1225 GO:0004751 ribose-5-phosphate isomerase activity molecular_function Clostridium Clostridium thermocellum 22.6719 98.7472 96.9038 224.296 228.218 292.399 GO:0004751 ribose-5-phosphate isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 26.7488 25.4178 26.6931 25.5749 29.1205 24.0404 GO:0004751 ribose-5-phosphate isomerase activity molecular_function Escherichia Escherichia coli 0.0953205 0 0.300724 0 0 0 GO:0004751 ribose-5-phosphate isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.366068 1.3183 1.01918 1.49649 0.69458 0.912054 GO:0004756 selenide, water dikinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.75728 11.4487 13.667 8.41754 10.591 12.1338 GO:0004760 serine-pyruvate transaminase activity molecular_function Clostridium Clostridium thermocellum 0.675045 12.1893 8.1666 8.05742 7.65503 4.29156 GO:0004764 shikimate 3-dehydrogenase (NADP+) activity molecular_function Clostridium Clostridium thermocellum 1.36543 6.36931 4.52466 37.8689 40.8847 40.2398 GO:0004764 shikimate 3-dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0.214289 0 0 0 0 0 GO:0004764 shikimate 3-dehydrogenase (NADP+) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.307155 1.98349 0.569964 0.0392948 0.171431 0.306379 GO:0004765 shikimate kinase activity molecular_function Clostridium Clostridium thermocellum 7.3903 57.9144 28.3575 153.827 70.6191 273.484 GO:0004765 shikimate kinase activity molecular_function Escherichia Escherichia coli 0.130659 0 0 0 0 0 GO:0004765 shikimate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0337583 0.453761 0.563829 0.379866 0.18085 0.494074 GO:0004766 spermidine synthase activity molecular_function Clostridium Clostridium thermocellum 2.75926 18.0253 17.4834 48.3895 53.496 53.4748 GO:0004766 spermidine synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 97.7919 83.4617 86.3589 70.7699 87.7041 54.3586 GO:0004766 spermidine synthase activity molecular_function Escherichia Escherichia coli 0.067784 0 0.125711 0 0 0.0451128 GO:0004775 succinate-CoA ligase (ADP-forming) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.235458 0.0984813 0.0935055 0.094208 0.210171 0.0682351 GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity molecular_function Escherichia Escherichia coli 0.0781861 0 0 0 0 0 GO:0004781 sulfate adenylyltransferase (ATP) activity molecular_function Escherichia Escherichia coli 0.178149 0 0 0 0 0 GO:0004783 sulfite reductase (NADPH) activity molecular_function Escherichia Escherichia coli 0.119503 0 0 0 0 0 GO:0004784 superoxide dismutase activity molecular_function Clostridium Clostridium thermocellum 0 0.178807 0 0 0.457259 0.12389 GO:0004784 superoxide dismutase activity molecular_function Escherichia Escherichia coli 0 0 0.242492 0 0 0 GO:0004784 superoxide dismutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 4.87415 1.09744 1.63826 1.06317 0.695709 0.552348 GO:0004788 thiamine diphosphokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.52963 3.21931 2.74946 2.52561 2.69027 2.35556 GO:0004788 thiamine diphosphokinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.265619 0.339924 0.32851 0 0.11852 0.1767 GO:0004789 thiamine-phosphate diphosphorylase activity molecular_function Clostridium Clostridium thermocellum 0.131947 2.4821 6.56239 1.72748 2.12055 2.28183 GO:0004789 thiamine-phosphate diphosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.149932 0.0960543 0.185071 0 0 0.26602 GO:0004789 thiamine-phosphate diphosphorylase activity molecular_function Escherichia Escherichia coli 0.100108 0 0 0 0 0 GO:0004789 thiamine-phosphate diphosphorylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.17251 0.551682 0 0.527918 0.205114 0.153254 GO:0004791 thioredoxin-disulfide reductase activity molecular_function Clostridium Clostridium thermocellum 3.34271 26.5836 22.3044 73.621 51.4425 40.9378 GO:0004791 thioredoxin-disulfide reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 60.5844 45.6812 40.6282 27.2136 35.3746 29.7026 GO:0004791 thioredoxin-disulfide reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.127572 1.10196 0.532751 0.456765 0.427222 0.424383 GO:0004792 thiosulfate sulfurtransferase activity molecular_function Escherichia Escherichia coli 0.421918 0 0 0 0 0.173886 GO:0004792 thiosulfate sulfurtransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.02534 2.16575 0 0 0 0 GO:0004794 L-threonine ammonia-lyase activity molecular_function Escherichia Escherichia coli 0.231423 0 0.0536766 0 0 0 GO:0004795 threonine synthase activity molecular_function Clostridium Clostridium thermocellum 9.68106 58.6653 53.2288 130.536 125.436 141.594 GO:0004795 threonine synthase activity molecular_function Escherichia Escherichia coli 0.0427508 0 0 0 0 0 GO:0004795 threonine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0907756 1.35027 0.631624 0.83581 0.648331 0.783345 GO:0004797 thymidine kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 18.8045 14.4913 14.601 13.952 18.8738 12.0016 GO:0004798 thymidylate kinase activity molecular_function Clostridium Clostridium thermocellum 1.85979 4.36492 5.40031 19.7196 19.5344 17.4885 GO:0004798 thymidylate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.01618 3.2385 4.17365 3.22284 2.45792 2.24471 GO:0004798 thymidylate kinase activity molecular_function Escherichia Escherichia coli 0.0986988 0 0 0 0 0 GO:0004798 thymidylate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.055875 0.42893 0.93298 0.457386 0.149685 1.03847 GO:0004799 thymidylate synthase activity molecular_function Clostridium Clostridium thermocellum 4.20754 24.2485 18.8704 62.4472 63.5952 70.4747 GO:0004799 thymidylate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.364099 1.92305 0.844391 0.372753 0.650436 0.54504 GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 135.437 314.936 341.745 128.573 149.254 152.303 GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity molecular_function Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:0004802 transketolase activity molecular_function Escherichia Escherichia coli 0.0263942 0 0 0 0 0 GO:0004803 transposase activity molecular_function Clostridium Clostridium thermocellum 50.6674 207.17 179.61 328.57 308.305 326.202 GO:0004803 transposase activity molecular_function Escherichia Escherichia coli 7.92575 0 2.48347 0 0 0.887541 GO:0004805 trehalose-phosphatase activity molecular_function Escherichia Escherichia coli 0.159945 0 0 0 0 0 GO:0004805 trehalose-phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.217079 0.139198 0.0770476 0.0672356 0 GO:0004807 triose-phosphate isomerase activity molecular_function Clostridium Clostridium thermocellum 7.97827 104.076 77.7508 385.024 369.989 319.97 GO:0004807 triose-phosphate isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 69.0326 107.358 122.921 115.124 93.868 41.6785 GO:0004807 triose-phosphate isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.179947 0.688949 0 0.0920195 0.281335 0.359091 GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0261755 0 0 0 0 0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.129638 0 1.08255 0.150216 0.181545 0.215377 GO:0004810 tRNA adenylyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.60429 7.88873 6.48377 27.1068 28.7997 21.395 GO:0004810 tRNA adenylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.83085 2.93031 0.514844 1.9865 2.52672 1.4395 GO:0004810 tRNA adenylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.122249 0.356213 0.552237 0.224105 0.257071 0.766173 GO:0004812 aminoacyl-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 5.3624 18.1744 10.1945 34.178 28.4465 43.0052 GO:0004812 aminoacyl-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.43158 29.0199 18.8658 23.913 24.1686 9.43613 GO:0004812 aminoacyl-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.346163 0.238035 0.167751 0.112264 0.131476 0.194066 GO:0004813 alanine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 5.49719 19.1865 11.5244 63.4788 64.6384 64.436 GO:0004813 alanine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 33.666 44.1163 47.612 43.4753 62.2984 46.8456 GO:0004813 alanine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0195891 0 0 0 0 0 GO:0004814 arginine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 14.0925 38.9658 49.3593 83.7525 86.937 71.8438 GO:0004814 arginine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 41.754 41.1333 32.755 51.7953 57.2362 34.3873 GO:0004814 arginine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.076655 0 0 0 0 0 GO:0004814 arginine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0792798 1.03517 0.646194 0.259569 0.184019 0.0843722 GO:0004815 aspartate-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.0965 18.8049 20.9213 20.1682 21.0927 17.8676 GO:0004815 aspartate-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0299426 0 0 0 0 0 GO:0004815 aspartate-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0417544 0.0801853 0.154985 0.213386 0.0372856 0.138863 GO:0004816 asparagine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.34199 16.3389 11.4461 45.0052 43.2546 38.7695 GO:0004816 asparagine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.2449 20.8917 17.6842 13.8413 16.2779 15.6655 GO:0004816 asparagine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0950045 0 0 0 0 0 GO:0004817 cysteine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 1.56572 12.2106 8.96696 28.6586 23.4713 15.921 GO:0004817 cysteine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.6957 7.68243 4.86418 7.07781 9.52005 7.78834 GO:0004817 cysteine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.039324 0 0.036491 0 0 0.0523243 GO:0004818 glutamate-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 4.28541 13.4853 13.6406 42.5905 41.3559 33.4363 GO:0004818 glutamate-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.1668 7.405 5.89757 6.48456 9.30782 6.88159 GO:0004818 glutamate-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0384004 0 0 0 0 0 GO:0004818 glutamate-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0321543 0.308746 0.0596757 0 0.0574259 0 GO:0004819 glutamine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.33414 19.5644 13.4457 57.1243 62.2455 49.6799 GO:0004820 glycine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 4.03843 22.7861 16.3044 71.33 61.2833 62.8522 GO:0004820 glycine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.6999 6.40707 6.34443 9.92818 11.3027 9.74119 GO:0004820 glycine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.334229 0 0 0 0 0 GO:0004820 glycine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.0904535 0.349394 0.176727 0.0701004 0.0835637 GO:0004821 histidine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.63978 11.8759 8.04715 27.4492 23.7777 26.3258 GO:0004821 histidine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.6129 19.4776 14.613 22.3125 23.2156 14.0687 GO:0004821 histidine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0432126 0 0 0 0 0.0287493 GO:0004821 histidine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.307325 0.866309 0.228328 0.209879 0.256377 0.327464 GO:0004822 isoleucine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 55.1984 36.1391 27.3652 30.631 32.1575 26.0457 GO:0004822 isoleucine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.00911402 0 0.0338298 0 0 0 GO:0004822 isoleucine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0977023 0.156263 0.120885 0.13308 0.0581638 0.173336 GO:0004823 leucine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 5.48015 36.422 27.236 91.0435 87.979 79.0557 GO:0004823 leucine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.2374 12.0659 12.6704 13.3937 15.282 10.5045 GO:0004823 leucine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0199779 0 0 0 0 0.0265826 GO:0004823 leucine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.209841 0.140161 0.237034 0.140044 0.105889 0.169909 GO:0004824 lysine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 1.45601 14.2331 9.50287 38.4728 37.9494 40.2274 GO:0004824 lysine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 37.675 31.0372 19.2826 53.2743 51.8031 42.9871 GO:0004824 lysine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.112236 0 0.0659455 0 0 0.046471 GO:0004824 lysine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0981884 0.125739 0.121517 0.100475 0.0292338 0 GO:0004825 methionine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.43692 9.97597 6.73366 33.4126 30.0803 23.122 GO:0004825 methionine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 24.9197 13.0987 14.9571 14.1977 14.6997 10.6684 GO:0004825 methionine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0386921 0 0 0 0 0 GO:0004825 methionine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.103382 0.049932699999999997 0.275362 0.120169 0.143261 GO:0004826 phenylalanine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 1.97312 28.3832 22.7411 42.6145 37.7424 32.7753 GO:0004826 phenylalanine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 42.5364 32.6279 31.8027 38.7024 45.6252 27.2614 GO:0004826 phenylalanine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0434313 0 0.0540825 0 0 0 GO:0004826 phenylalanine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.153869 0.502441 0.12517 0.486012 0.204919 0.40194 GO:0004827 proline-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.52422 18.083 14.3411 44.9913 40.6442 43.3146 GO:0004827 proline-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.8478 24.8163 15.5358 30.7611 38.881100000000004 29.2867 GO:0004827 proline-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0309634 0 0 0 0 0 GO:0004827 proline-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0748079 0.143708 0.138837 0.228929 0.133603 0.0993774 GO:0004828 serine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.40476 16.8858 13.3064 39.3101 43.4919 37.9766 GO:0004828 serine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 7.1783 5.77516 2.36222 9.40884 9.56265 9.14085 GO:0004828 serine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0212417 0 0 0 0 0 GO:0004828 serine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.139675 0.167605 0.22675 0.303739 0.15587 0.232323 GO:0004829 threonine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 4.03547 29.0893 18.9049 72.3296 67.5599 52.1923 GO:0004829 threonine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 50.5135 73.2095 59.1197 59.8116 67.3875 40.0379 GO:0004829 threonine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0 0 0.0499778 0 0 0 GO:0004829 threonine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.116562 0.167885 0.162248 0.208735 0.117087 0.387776 GO:0004830 tryptophan-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.31474 19.8864 9.66349 46.4333 46.0442 41.3628 GO:0004830 tryptophan-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.7707 13.9259 10.8528 20.4638 22.8987 18.5213 GO:0004830 tryptophan-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.113597 0 0 0 0 0 GO:0004830 tryptophan-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.154209 0.395045 0.28638 0.39444 0.137792 0.0684291 GO:0004831 tyrosine-tRNA ligase activity molecular_function Clostridium Clostridium thermocellum 0.924769 11.7781 8.03421 31.9374 31.988 25.6617 GO:0004831 tyrosine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.46072 1.20339 1.41855 1.02027 1.26406 0.678696 GO:0004831 tyrosine-tRNA ligase activity molecular_function Escherichia Escherichia coli 0.0432126 0 0 0 0 0 GO:0004831 tyrosine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0300155 0.230474 0.111368 0.0307146 0.0535845 0.239437 GO:0004832 valine-tRNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 52.0003 32.0423 38.9351 29.4323 33.8191 26.451 GO:0004832 valine-tRNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.038206 0.348559 0.0354536 0.215052 0.12796 0.127124 GO:0004834 tryptophan synthase activity molecular_function Clostridium Clostridium thermocellum 13.9437 68.4342 52.2207 236.363 182.933 178.752 GO:0004834 tryptophan synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 19.9345 8.31616 5.76098 13.2171 16.6092 4.21343 GO:0004834 tryptophan synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.03346 0.172599 0.233876 0.889778 0.688568 1.5761 GO:0004837 tyrosine decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0258109 0.148609 0 0.369296 0.115025 0 GO:0004844 uracil DNA N-glycosylase activity molecular_function Escherichia Escherichia coli 0.315126 0 0 0 0 0 GO:0004845 uracil phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 11.8634 81.0858 76.5841 171.093 169.026 196.382 GO:0004845 uracil phosphoribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.1412 22.9034 23.9156 12.148 11.0766 13.6792 GO:0004845 uracil phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0975079 0 0.179027 0.149818 0.130738 0 GO:0004849 uridine kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 25.3401 45.4046 25.477 28.4036 30.6211 29.9562 GO:0004850 uridine phosphorylase activity molecular_function Escherichia Escherichia coli 0.0792312 0 0 0 0 0.105683 GO:0004851 uroporphyrin-III C-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.0182523 12.9279 7.92212 23.4066 22.693 32.3801 GO:0004851 uroporphyrin-III C-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0471013 0 0.0874161 0 0 0 GO:0004852 uroporphyrinogen-III synthase activity molecular_function Clostridium Clostridium thermocellum 0.0182523 12.9279 7.92212 23.4066 22.693 32.3801 GO:0004852 uroporphyrinogen-III synthase activity molecular_function Escherichia Escherichia coli 0.0819776 0 0 0 0 0 GO:0004852 uroporphyrinogen-III synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0794256 0 0.221111 0 0.0354626 0 GO:0004853 uroporphyrinogen decarboxylase activity molecular_function Clostridium Clostridium thermocellum 0.42605 155.443 166.82 60.6048 59.1935 57.2473 GO:0004854 xanthine dehydrogenase activity molecular_function Escherichia Escherichia coli 0.048438 0 0 0 0 0.0720834 GO:0004855 xanthine oxidase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0119007 GO:0004856 xylulokinase activity molecular_function Escherichia Escherichia coli 0.0744919 0 0 0 0 0.0247716 GO:0004866 endopeptidase inhibitor activity molecular_function Escherichia Escherichia coli 0.00556563 0 0 0 0 0 GO:0004871 signal transducer activity molecular_function Clostridium Clostridium thermocellum 24.3366 80.2366 90.3996 434.331 412.727 369.316 GO:0004871 signal transducer activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 36.5893 23.1342 24.9425 20.3801 23.6085 19.4238 GO:0004871 signal transducer activity molecular_function Escherichia Escherichia coli 0.0269046 0 0.049932699999999997 0 0 0.183362 GO:0004872 receptor activity molecular_function Escherichia Escherichia coli 0.102053 0 0.306498 0 0 0.148791 GO:0004984 olfactory receptor activity molecular_function Escherichia Escherichia coli 0.361523 0 0.379841 0 0 0.0899345 GO:0005048 signal sequence binding molecular_function Escherichia Escherichia coli 0.195599 0 0 0 0 0.13909 GO:0005198 structural molecule activity molecular_function Clostridium Clostridium thermocellum 30.9275 52.5408 36.4512 711.565 684.212 559.164 GO:0005198 structural molecule activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0268317 0 0 0 0 0 GO:0005198 structural molecule activity molecular_function Escherichia Escherichia coli 15.2031 0 17.7881 0 0 18.552 GO:0005215 transporter activity molecular_function Clostridium Clostridium thermocellum 17.2173 69.7364 58.8712 236.604 218.35 146.78 GO:0005215 transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1170.78 677.898 915.494 494.015 594.402 583.214 GO:0005215 transporter activity molecular_function Escherichia Escherichia coli 4.18127 0 2.94355 0 0 1.10715 GO:0005215 transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.99944 0.986914 3.49723 2.09404 1.91734 1.21358 GO:0005216 ion channel activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 40.5509 80.209 60.3346 57.6281 71.0274 79.7315 GO:0005216 ion channel activity molecular_function Escherichia Escherichia coli 0.372484 0 0.517821 0 0 0 GO:0005247 voltage-gated chloride channel activity molecular_function Clostridium Clostridium thermocellum 1.39583 11.857 9.61176 15.9613 18.6339 24.4157 GO:0005247 voltage-gated chloride channel activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.19324 4.35679 2.96448 2.99088 3.06988 3.52225 GO:0005247 voltage-gated chloride channel activity molecular_function Escherichia Escherichia coli 0.0379386 0 0 0 0 0 GO:0005262 calcium channel activity molecular_function Escherichia Escherichia coli 0.0880536 0 0 0 0 0 GO:0005267 potassium channel activity molecular_function Escherichia Escherichia coli 0.0557049 0 0 0 0 0 GO:0005304 L-valine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.26941 0 0 0 0 0 GO:0005315 inorganic phosphate transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 1.96736 3.66458 3.21293 1.37838 1.46176 2.78587 GO:0005315 inorganic phosphate transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 121.811 23.8095 18.4492 31.11 37.3002 22.008 GO:0005315 inorganic phosphate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.161598 0 0.310332 0 0 0.0718247 GO:0005315 inorganic phosphate transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.491136 0.96423 0.873439 0.606732 0.532394 0.857013 GO:0005328 neurotransmitter:sodium symporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 107.983 27.1758 41.6894 22.6594 27.5648 25.5205 GO:0005337 nucleoside transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0446465 0 0 0 0 0 GO:0005344 oxygen transporter activity molecular_function Escherichia Escherichia coli 0.0466881 0 0 0 0 0 GO:0005345 purine nucleobase transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.3584 4.17556 5.65101 7.77604 5.76994 3.99521 GO:0005345 purine nucleobase transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0379872 0 0 0 0 0 GO:0005351 sugar:proton symporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 92.4241 20.5231 28.3484 18.3597 14.3406 8.53233 GO:0005351 sugar:proton symporter activity molecular_function Escherichia Escherichia coli 0.439879 0 0.346778 0 0 0.255089 GO:0005354 galactose transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0354596 0 0 0 0 0 GO:0005355 glucose transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0756585 0 0.140506 0 0 0 GO:0005363 maltose transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 134.045 63.4878 144.991 25.642 38.6514 48.4664 GO:0005363 maltose transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.116659 0 0 0 0 0 GO:0005384 manganese ion transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 0.489095 3.44363 0.302709 9.39949 5.19327 9.04121 GO:0005384 manganese ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.233124 0 0 0 0 0 GO:0005384 manganese ion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.222735 0.184213 0.106778 0.239534 GO:0005385 zinc ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0.113894 0 0 0.0774516 GO:0005388 calcium-transporting ATPase activity molecular_function Clostridium Clostridium thermocellum 1.39102 2.74772 3.00625 9.27501 10.5159 12.0989 GO:0005388 calcium-transporting ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.7153 17.3383 18.1821 15.2639 15.476 11.57 GO:0005388 calcium-transporting ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0610275 0.195702 0.264774 0.18762 0.0910003 0.162697 GO:0005415 nucleoside:sodium symporter activity molecular_function Escherichia Escherichia coli 0.0461534 0 0 0 0 0 GO:0005451 monovalent cation:proton antiporter activity molecular_function Clostridium Clostridium thermocellum 0.298211 3.37077 2.55194 7.38812 7.07064 9.19162 GO:0005451 monovalent cation:proton antiporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 172.061 32.706 52.4692 40.9061 59.7672 30.9783 GO:0005506 iron ion binding molecular_function Clostridium Clostridium thermocellum 153.719 2243.4 1268.9 6534.09 4641.59 8242.74 GO:0005506 iron ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 5715.6 15150.5 12874.2 5720.03 6389.76 7852.8 GO:0005506 iron ion binding molecular_function Escherichia Escherichia coli 1.76977 0 1.52897 0 0 0.691244 GO:0005506 iron ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.03361 19.3303 9.12389 7.69832 4.90158 10.6172 GO:0005507 copper ion binding molecular_function Clostridium Clostridium thermocellum 16.9333 234.828 152.623 532.191 394.881 686.647 GO:0005507 copper ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 50.2588 66.8372 80.2765 34.749 48.1546 40.7722 GO:0005507 copper ion binding molecular_function Escherichia Escherichia coli 0.413679 0 0.128824 0 0 0 GO:0005509 calcium ion binding molecular_function Clostridium Clostridium thermocellum 8.36538 31.6643 27.2588 94.0011 100.804 175.611 GO:0005509 calcium ion binding molecular_function Escherichia Escherichia coli 0.447705 0 0.245379 0 0 0.040844 GO:0005509 calcium ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.06843 0.511636 0.991347 1.75981 0 2.85895 GO:0005524 ATP binding molecular_function Clostridium Clostridium thermocellum 668.581 4222.52 3620.11 10383.3 9584.47 9867.57 GO:0005524 ATP binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 6241.98 4663.37 4935.41 3656.83 4405.54 3431.7 GO:0005524 ATP binding molecular_function Escherichia Escherichia coli 15.6811 0 11.4563 0 0 4.07425 GO:0005524 ATP binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 25.0222 52.7989 52.6346 42.7274 25.8365 46.0619 GO:0005525 GTP binding molecular_function Clostridium Clostridium thermocellum 123.793 759.52 591.357 2382.52 2088.79 1951.49 GO:0005525 GTP binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 716.148 568.669 518.586 553.919 664.223 544.29 GO:0005525 GTP binding molecular_function Escherichia Escherichia coli 1.19423 0 0.246416 0 0 0.607486 GO:0005525 GTP binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 12.755 18.3124 15.8513 12.7497 6.82856 13.4991 GO:0005528 FK506 binding molecular_function Escherichia Escherichia coli 0.103098 0 0 0 0 0 GO:0005534 galactose binding molecular_function Escherichia Escherichia coli 0.120475 0 0 0 0 0 GO:0005542 folic acid binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 38.7195 12.9166 45.4751 2.07255 4.42169 4.76219 GO:0005543 phospholipid binding molecular_function Escherichia Escherichia coli 0.0500177 0 0 0 0 0 GO:0005975 carbohydrate metabolic process biological_process Clostridium Clostridium thermocellum 126.47 361.161 325.987 955.177 847.176 910.707 GO:0005975 carbohydrate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 672.536 603.786 700.263 437.905 496.515 409.395 GO:0005975 carbohydrate metabolic process biological_process Escherichia Escherichia coli 145.99 0 66.1159 0 0 15.6679 GO:0005975 carbohydrate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.83961 4.36361 3.36209 4.37366 2.45349 3.87423 GO:0005977 glycogen metabolic process biological_process Escherichia Escherichia coli 0.0251304 0 0 0 0 0 GO:0005978 glycogen biosynthetic process biological_process Clostridium Clostridium thermocellum 6.04374 39.584 28.5428 256.93 251.996 223.186 GO:0005978 glycogen biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 169.299 136.07 138.294 110.092 135.73 115.105 GO:0005978 glycogen biosynthetic process biological_process Escherichia Escherichia coli 0.596932 0 0.0787106 0 0 0 GO:0005980 glycogen catabolic process biological_process Clostridium Clostridium thermocellum 1.08846 8.18431 6.03654 29.6421 28.7723 30.4393 GO:0005980 glycogen catabolic process biological_process Escherichia Escherichia coli 0.144317 0 0.228779 0 0 0 GO:0005985 sucrose metabolic process biological_process Escherichia Escherichia coli 0 0 0.165946 0 0 0 GO:0005988 lactose metabolic process biological_process Clostridium Clostridium thermocellum 9.86686 28.7165 21.6438 133.033 107.045 143.081 GO:0005988 lactose metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 125.074 105.814 111.725 74.0842 99.1241 73.0471 GO:0005991 trehalose metabolic process biological_process Escherichia Escherichia coli 0.13044 0 0.0219217 0 0 0 GO:0005992 trehalose biosynthetic process biological_process Escherichia Escherichia coli 0.159945 0 0 0 0 0 GO:0005992 trehalose biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.162546 0.35626 0.139198 0.151235 0.0672356 0.0482173 GO:0005993 trehalose catabolic process biological_process Escherichia Escherichia coli 0.0972162 0 0.200904 0 0 0 GO:0005995 melibiose catabolic process biological_process Escherichia Escherichia coli 0.0402961 0 0 0 0 0 GO:0005996 monosaccharide metabolic process biological_process Clostridium Clostridium thermocellum 8.9723 20.5811 17.6418 48.8933 48.7887 64.0767 GO:0005996 monosaccharide metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.6022 8.82271 4.81488 8.87252 10.4749 8.15105 GO:0005998 xylulose catabolic process biological_process Escherichia Escherichia coli 0.0744919 0 0 0 0 0.0247716 GO:0005999 xylulose biosynthetic process biological_process Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:0006000 fructose metabolic process biological_process Escherichia Escherichia coli 0 0 0.33947 0 0 0 GO:0006002 fructose 6-phosphate metabolic process biological_process Clostridium Clostridium thermocellum 12.712 116.88 72.6404 379.328 344.769 269.537 GO:0006002 fructose 6-phosphate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 233.381 310.772 242.865 253.449 310.629 177.948 GO:0006002 fructose 6-phosphate metabolic process biological_process Escherichia Escherichia coli 0.209744 0 0.0554808 0 0 0 GO:0006004 fucose metabolic process biological_process Escherichia Escherichia coli 0.0410252 0 0 0 0 0.166448 GO:0006006 glucose metabolic process biological_process Clostridium Clostridium thermocellum 28.2254 362.751 253.872 1053.85 1079.39 914.434 GO:0006006 glucose metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 75.8646 274.922 211.047 183.353 266.927 188.019 GO:0006006 glucose metabolic process biological_process Escherichia Escherichia coli 0.474585 0 0.298424 0 0 0.247878 GO:0006006 glucose metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.067784 0 0.251558 0.0693628 0 0.0901932 GO:0006007 glucose catabolic process biological_process Clostridium Clostridium thermocellum 4.40013 74.3333 74.8652 106.757 98.0077 79.9185 GO:0006007 glucose catabolic process biological_process Escherichia Escherichia coli 0.052278 0 0 0 0 0 GO:0006011 UDP-glucose metabolic process biological_process Clostridium Clostridium thermocellum 3.00262 16.584 8.70638 40.1594 35.961 49.9037 GO:0006011 UDP-glucose metabolic process biological_process Escherichia Escherichia coli 0.0913346 0 0 0 0 0.0869269 GO:0006011 UDP-glucose metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.411541 1.18523 1.3379 0.63185 0.398466 0.410963 GO:0006012 galactose metabolic process biological_process Clostridium Clostridium thermocellum 2.6548 27.3309 23.0112 46.6437 55.0428 57.194 GO:0006012 galactose metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 9.59595 13.7924 5.45755 15.3531 18.278 12.0259 GO:0006012 galactose metabolic process biological_process Escherichia Escherichia coli 0.0280226 0 0 0 0 0 GO:0006012 galactose metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.117413 0.11267 0.108932 0.420429 0.104868 0.546495 GO:0006013 mannose metabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0327593 GO:0006014 D-ribose metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.484137 1.66564 2.81522 0.0990826 0.4323 1.37424 GO:0006014 D-ribose metabolic process biological_process Escherichia Escherichia coli 0.217351 0 0 0 0 0 GO:0006014 D-ribose metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.10464 0.913123 0.976913 1.40999 0.602386 1.25934 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 8.49303 51.9047 43.1504 140.288 142.991 139.676 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 32.7395 26.4632 18.8907 36.513 43.2726 31.3404 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.060215 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0685617 0.395372 0.191116 0.56194 0.0306445 0.548177 GO:0006021 inositol biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.152362 0.292504 0.471046 1.14353 0.702936 2.02296 GO:0006024 glycosaminoglycan biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0682701 0.087373 0.168878 0.0465817 0 0.121109 GO:0006032 chitin catabolic process biological_process Clostridium Clostridium thermocellum 5.29947 8.80582 9.09723 23.3712 19.9315 20.0054 GO:0006044 N-acetylglucosamine metabolic process biological_process Clostridium Clostridium thermocellum 1.20035 4.47483 3.62673 11.2753 13.3918 13.4697 GO:0006044 N-acetylglucosamine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 92.503 36.1405 61.5543 21.013 24.3019 21.5417 GO:0006044 N-acetylglucosamine metabolic process biological_process Escherichia Escherichia coli 0.308054 0 0 0 0 0.0988923 GO:0006047 UDP-N-acetylglucosamine metabolic process biological_process Clostridium Clostridium thermocellum 2.92271 22.322 22.6089 55.7991 61.8888 59.941 GO:0006047 UDP-N-acetylglucosamine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 38.8843 38.8641 37.9197 31.6798 32.5771 32.4612 GO:0006047 UDP-N-acetylglucosamine metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.16483 0 0.767079 0.359498 0.166049 0.219937 GO:0006048 UDP-N-acetylglucosamine biosynthetic process biological_process Clostridium Clostridium thermocellum 6.26833 35.7007 27.2547 96.8199 94.1636 84.6506 GO:0006048 UDP-N-acetylglucosamine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 17.0894 14.1176 12.1005 34.4997 35.4584 19.8786 GO:0006048 UDP-N-acetylglucosamine biosynthetic process biological_process Escherichia Escherichia coli 0.019905 0 0.0738842 0 0 0 GO:0006062 sorbitol catabolic process biological_process Escherichia Escherichia coli 0.0770925 0 0 0 0 0 GO:0006064 glucuronate catabolic process biological_process Escherichia Escherichia coli 0.057309 0 0.0705914 0 0 0 GO:0006065 UDP-glucuronate biosynthetic process biological_process Escherichia Escherichia coli 0.143394 0 0 0 0 0.0636106 GO:0006066 alcohol metabolic process biological_process Clostridium Clostridium thermocellum 0.658664 16.1959 9.70495 72.5495 65.9282 34.2944 GO:0006066 alcohol metabolic process biological_process Escherichia Escherichia coli 0.0192731 0 0 0 0 0 GO:0006068 ethanol catabolic process biological_process Escherichia Escherichia coli 0.0328591 0 0 0 0 0 GO:0006069 ethanol oxidation biological_process Escherichia Escherichia coli 0 0 0.0939565 0 0 0.0336971 GO:0006071 glycerol metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 44.0015 40.5883 39.0635 39.6642 46.5421 34.0083 GO:0006071 glycerol metabolic process biological_process Escherichia Escherichia coli 0.576176 0 0.232298 0 0 0.231449 GO:0006072 glycerol-3-phosphate metabolic process biological_process Escherichia Escherichia coli 0.0716727 0 0.0664868 0 0 0 GO:0006080 substituted mannan metabolic process biological_process Clostridium Clostridium thermocellum 41.2293 46.4253 52.9957 128.966 117.098 135.834 GO:0006081 cellular aldehyde metabolic process biological_process Clostridium Clostridium thermocellum 0.229819 2.94146 1.49279 7.42607 6.99288 7.20601 GO:0006082 organic acid metabolic process biological_process Clostridium Clostridium thermocellum 4.97497 31.7717 26.5377 74.1942 75.7388 54.5204 GO:0006082 organic acid metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 32.0488 43.0591 49.0291 50.1978 48.3386 32.4178 GO:0006082 organic acid metabolic process biological_process Escherichia Escherichia coli 0.0923068 0 0 0 0 0.0613792 GO:0006084 acetyl-CoA metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.8095 4.95529 3.92538 3.07335 3.79558 3.06634 GO:0006084 acetyl-CoA metabolic process biological_process Escherichia Escherichia coli 0.201335 0 0 0 0 0.0829169 GO:0006084 acetyl-CoA metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0834844 0 0 0.294885 0.159451 0.11144 GO:0006085 acetyl-CoA biosynthetic process biological_process Clostridium Clostridium thermocellum 8.80132 57.9387 50.6598 123.994 132.039 128.484 GO:0006085 acetyl-CoA biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 32.0488 43.0591 49.0291 50.1978 48.3386 32.4178 GO:0006085 acetyl-CoA biosynthetic process biological_process Escherichia Escherichia coli 0.0923068 0 0 0 0 0.0613792 GO:0006089 lactate metabolic process biological_process Escherichia Escherichia coli 0.0156518 0 0 0 0 0 GO:0006090 pyruvate metabolic process biological_process Clostridium Clostridium thermocellum 2.59281 11.6392 13.25 49.2864 44.0848 41.199 GO:0006090 pyruvate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 53.4174 54.7495 42.6241 62.2203 69.7192 37.1381 GO:0006090 pyruvate metabolic process biological_process Escherichia Escherichia coli 0.046445 0 0 0 0 0 GO:0006090 pyruvate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0510385 0.318407 0.355077 0.495985 0.273435 0.322516 GO:0006091 generation of precursor metabolites and energy biological_process Clostridium Clostridium thermocellum 0.130416 31.3103 29.1451 43.3765 37.6878 33.5279 GO:0006094 gluconeogenesis biological_process Clostridium Clostridium thermocellum 12.7286 181.224 162.281 648.555 592.409 530.483 GO:0006094 gluconeogenesis biological_process Coprothermobacter Coprothermobacter proteolyticus 314.784 592.819 453.248 357.14 413.998 305.421 GO:0006094 gluconeogenesis biological_process Escherichia Escherichia coli 0.241582 0 0.0742451 0 0 0.0216994 GO:0006094 gluconeogenesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.671837 1.77439 1.25693 1.28133 1.11416 1.56608 GO:0006096 glycolytic process biological_process Clostridium Clostridium thermocellum 50.7733 801.418 588.203 2284.02 2295.85 2088.11 GO:0006096 glycolytic process biological_process Coprothermobacter Coprothermobacter proteolyticus 418.009 1148.82 915.105 846.277 1043.22 643.776 GO:0006096 glycolytic process biological_process Escherichia Escherichia coli 0.555858 0 0.0707719 0 0 0.0716306 GO:0006096 glycolytic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.24412 1.88729 1.24516 1.95952 0.947571 1.83782 GO:0006097 glyoxylate cycle biological_process Clostridium Clostridium thermocellum 2.4552 47.411 32.8214 119.773 121.21 121.8 GO:0006097 glyoxylate cycle biological_process Escherichia Escherichia coli 0.575107 0 0.190484 0 0 0.0569164 GO:0006098 pentose-phosphate shunt biological_process Clostridium Clostridium thermocellum 32.0239 217.092 182.216 663.372 640.793 678.726 GO:0006098 pentose-phosphate shunt biological_process Coprothermobacter Coprothermobacter proteolyticus 235.056 450.62 492.149 271.598 276.218 222.433 GO:0006098 pentose-phosphate shunt biological_process Escherichia Escherichia coli 0.189086 0 0.498921 0 0 0.1225 GO:0006098 pentose-phosphate shunt biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.179947 0.688949 0 0.0920195 0.281335 0.359091 GO:0006099 tricarboxylic acid cycle biological_process Clostridium Clostridium thermocellum 2.4552 47.411 32.8214 119.773 121.21 121.8 GO:0006099 tricarboxylic acid cycle biological_process Escherichia Escherichia coli 0.908024 0 0.124674 0 0 0.125119 GO:0006099 tricarboxylic acid cycle biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.746353 0.712379 0.391478 0.896792 0.728958 0.325071 GO:0006102 isocitrate metabolic process biological_process Clostridium Clostridium thermocellum 2.4552 47.411 32.8214 119.773 121.21 121.8 GO:0006107 oxaloacetate metabolic process biological_process Escherichia Escherichia coli 0.0194432 0 0 0 0 0 GO:0006107 oxaloacetate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0342444 0.262166 0 0.262877 0.15294 0.159528 GO:0006108 malate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.7036 8.48671 7.60015 8.90226 8.78091 8.77558 GO:0006108 malate metabolic process biological_process Escherichia Escherichia coli 0.211032 0 0.212947 0 0 0.0835637 GO:0006108 malate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.440074 0.281489 0.162202 0.240295 0.104847 0 GO:0006109 regulation of carbohydrate metabolic process biological_process Clostridium Clostridium thermocellum 48.7367 313.415 223.445 763.953 780.967 958.252 GO:0006112 energy reserve metabolic process biological_process Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:0006119 oxidative phosphorylation biological_process Escherichia Escherichia coli 0 0 0.0646374 0 0 0.023187 GO:0006139 nucleobase-containing compound metabolic process biological_process Clostridium Clostridium thermocellum 0.750728 5.25428 4.94361 11.7933 12.995 14.2713 GO:0006139 nucleobase-containing compound metabolic process biological_process Escherichia Escherichia coli 0.0414384 0 0 0 0 0 GO:0006139 nucleobase-containing compound metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0605657 0.0581553 0.22481 0.108459 0.0809953 0.181324 GO:0006144 purine nucleobase metabolic process biological_process Escherichia Escherichia coli 0.206025 0 0 0 0 0.34166 GO:0006146 adenine catabolic process biological_process Escherichia Escherichia coli 0.0149956 0 0.0278306 0 0 0 GO:0006146 adenine catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.148644 0.127232 0.24592 0.0508594 0.103349 0.308642 GO:0006163 purine nucleotide metabolic process biological_process Clostridium Clostridium thermocellum 4.42378 27.4467 20.7349 59.5457 61.5965 71.5612 GO:0006163 purine nucleotide metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 39.9694 79.6803 76.3232 58.9659 71.4159 58.7156 GO:0006163 purine nucleotide metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.235117 0.564237 1.08797 0.960733 0.471539 1.87452 GO:0006164 purine nucleotide biosynthetic process biological_process Clostridium Clostridium thermocellum 8.04685 56.8594 38.1559 166.347 169.664 171.35 GO:0006164 purine nucleotide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 10.1493 7.35935 4.96675 6.47417 8.13417 6.97611 GO:0006164 purine nucleotide biosynthetic process biological_process Escherichia Escherichia coli 0.135957 0 0 0 0 0 GO:0006166 purine ribonucleoside salvage biological_process Clostridium Clostridium thermocellum 2.33922 13.577 10.8916 51.0264 39.3707 68.6689 GO:0006166 purine ribonucleoside salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 8.76042 9.12357 11.0711 12.0851 15.1185 13.2017 GO:0006166 purine ribonucleoside salvage biological_process Escherichia Escherichia coli 0.174041 0 0.23311 0 0 0.381987 GO:0006166 purine ribonucleoside salvage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.634761 0.567212 0.199956 0.160884 0.09333 GO:0006168 adenine salvage biological_process Clostridium Clostridium thermocellum 5.3083 25.8836 13.0491 63.7916 59.4961 59.5095 GO:0006168 adenine salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 82.9271 58.608 43.511 37.0193 45.5653 50.1944 GO:0006168 adenine salvage biological_process Escherichia Escherichia coli 0 0 0.224404 0 0 0 GO:0006171 cAMP biosynthetic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0269706 GO:0006177 GMP biosynthetic process biological_process Clostridium Clostridium thermocellum 3.92593 27.1335 16.1024 89.4446 80.4397 68.3222 GO:0006177 GMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 123.331 96.3271 85.7414 62.3909 84.3424 51.6951 GO:0006177 GMP biosynthetic process biological_process Escherichia Escherichia coli 0.0709435 0 0 0 0 0 GO:0006177 GMP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.196766 0.684375 1.06555 1.21234 0.43191 1.26173 GO:0006183 GTP biosynthetic process biological_process Clostridium Clostridium thermocellum 1.86167 12.8491 11.2268 58.815 46.6577 64.3269 GO:0006183 GTP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 161.758 282.441 228.356 175.603 195.079 248.125 GO:0006183 GTP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.396861 0.152529 0.883498 0.485838 0.638087 0.949793 GO:0006189 'de novo' IMP biosynthetic process biological_process Clostridium Clostridium thermocellum 19.8679 63.0196 46.6489 320.659 304.833 273.568 GO:0006189 'de novo' IMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 59.7195 38.6645 42.6321 55.2302 70.886 51.3796 GO:0006189 'de novo' IMP biosynthetic process biological_process Escherichia Escherichia coli 0.42379 0 0.361257 0 0 0.124181 GO:0006189 'de novo' IMP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.99954 5.6462 6.32635 3.39607 1.86248 4.00336 GO:0006206 pyrimidine nucleobase metabolic process biological_process Clostridium Clostridium thermocellum 0.738284 1.98489 2.77977 9.99093 9.33907 7.15631 GO:0006206 pyrimidine nucleobase metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 30.5868 22.757 25.5162 24.0789 31.9322 18.0353 GO:0006206 pyrimidine nucleobase metabolic process biological_process Escherichia Escherichia coli 0.195016 0 0.0567438 0 0 0.040844 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process biological_process Clostridium Clostridium thermocellum 3.23081 20.254 17.1549 59.8246 63.6541 60.5915 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 4.33669 2.70082 4.38438 1.31476 1.3433 1.58195 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process biological_process Escherichia Escherichia coli 0.305259 0 0.0439787 0 0 0 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.509024 0.911256 0.374112 1.16977 0.507241 1.27461 GO:0006208 pyrimidine nucleobase catabolic process biological_process Escherichia Escherichia coli 0.0786479 0 0 0 0 0 GO:0006212 uracil catabolic process biological_process Escherichia Escherichia coli 0.0551702 0 0 0 0 0.0548468 GO:0006213 pyrimidine nucleoside metabolic process biological_process Clostridium Clostridium thermocellum 0.738284 1.98489 2.77977 9.99093 9.33907 7.15631 GO:0006213 pyrimidine nucleoside metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 30.5868 22.757 25.5162 24.0789 31.9322 18.0353 GO:0006220 pyrimidine nucleotide metabolic process biological_process Clostridium Clostridium thermocellum 6.82242 51.3493 27.5884 104.762 118.867 125.629 GO:0006220 pyrimidine nucleotide metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0723289 0.138901 0 0.740408 0.38718 0.77083 GO:0006221 pyrimidine nucleotide biosynthetic process biological_process Clostridium Clostridium thermocellum 0.628551 4.09094 1.61945 11.9282 7.41667 12.4429 GO:0006221 pyrimidine nucleotide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 9.50019 8.84372 6.63997 6.88117 9.53507 11.2686 GO:0006222 UMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.864033 0.484005 0.13365 0.257804 0.353627 0.431174 GO:0006223 uracil salvage biological_process Clostridium Clostridium thermocellum 10.1241 63.2315 62.446 131.224 128.121 141.808 GO:0006223 uracil salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 14.1117 13.8508 17.5205 7.38217 5.14641 7.25436 GO:0006223 uracil salvage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0975079 0 0.179027 0.149818 0.130738 0 GO:0006226 dUMP biosynthetic process biological_process Clostridium Clostridium thermocellum 2.44795 10.3579 10.2479 25.2983 25.9347 35.8891 GO:0006226 dUMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.83 23.6456 13.4701 22.3517 31.1397 20.7496 GO:0006226 dUMP biosynthetic process biological_process Escherichia Escherichia coli 0.0786479 0 0 0 0 0 GO:0006226 dUMP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.266421 0.308093 0 0.219603 0.191159 0 GO:0006228 UTP biosynthetic process biological_process Clostridium Clostridium thermocellum 1.86167 12.8491 11.2268 58.815 46.6577 64.3269 GO:0006228 UTP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 161.758 282.441 228.356 175.603 195.079 248.125 GO:0006228 UTP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.396861 0.152529 0.883498 0.485838 0.638087 0.949793 GO:0006229 dUTP biosynthetic process biological_process Clostridium Clostridium thermocellum 2.44795 10.3579 10.2479 25.2983 25.9347 35.8891 GO:0006229 dUTP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.83 23.6456 13.4701 22.3517 31.1397 20.7496 GO:0006229 dUTP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.107302 0 0 0.219603 0.04792 0 GO:0006231 dTMP biosynthetic process biological_process Clostridium Clostridium thermocellum 4.20754 24.2485 18.8704 62.4472 63.5952 70.4747 GO:0006231 dTMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 32.4181 24.5272 22.7811 26.6489 29.5605 19.1002 GO:0006231 dTMP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.364099 1.92305 0.844391 0.372753 0.650436 0.54504 GO:0006233 dTDP biosynthetic process biological_process Clostridium Clostridium thermocellum 1.85979 4.36492 5.40031 19.7196 19.5344 17.4885 GO:0006233 dTDP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 6.01618 3.2385 4.17365 3.22284 2.45792 2.24471 GO:0006233 dTDP biosynthetic process biological_process Escherichia Escherichia coli 0.0986988 0 0 0 0 0 GO:0006233 dTDP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.055875 0.42893 0.93298 0.457386 0.149685 1.03847 GO:0006235 dTTP biosynthetic process biological_process Clostridium Clostridium thermocellum 1.85979 4.36492 5.40031 19.7196 19.5344 17.4885 GO:0006235 dTTP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 6.01618 3.2385 4.17365 3.22284 2.45792 2.24471 GO:0006235 dTTP biosynthetic process biological_process Escherichia Escherichia coli 0.0986988 0 0 0 0 0 GO:0006235 dTTP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.419974 2.35198 1.77737 0.83014 0.8001 1.58351 GO:0006241 CTP biosynthetic process biological_process Clostridium Clostridium thermocellum 1.86167 12.8491 11.2268 58.815 46.6577 64.3269 GO:0006241 CTP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 161.758 282.441 228.356 175.603 195.079 248.125 GO:0006241 CTP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.396861 0.152529 0.883498 0.485838 0.638087 0.949793 GO:0006259 DNA metabolic process biological_process Escherichia Escherichia coli 0.200484 0 0 0 0 0 GO:0006260 DNA replication biological_process Clostridium Clostridium thermocellum 55.3214 303.437 224.862 981.635 824.881 824.135 GO:0006260 DNA replication biological_process Coprothermobacter Coprothermobacter proteolyticus 526.611 310.035 334.161 221.2 284.822 225.705 GO:0006260 DNA replication biological_process Escherichia Escherichia coli 2.13929 0 2.35784 0 0 0.642768 GO:0006260 DNA replication biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.4003 4.194 4.14036 3.32961 2.10542 7.68398 GO:0006261 DNA-dependent DNA replication biological_process Clostridium Clostridium thermocellum 7.73596 56.6698 47.0745 134.301 126.136 128.493 GO:0006261 DNA-dependent DNA replication biological_process Coprothermobacter Coprothermobacter proteolyticus 27.2593 19.3438 23.3301 16.2397 16.4988 12.3178 GO:0006261 DNA-dependent DNA replication biological_process Escherichia Escherichia coli 0.0136346 0 0 0 0 0 GO:0006261 DNA-dependent DNA replication biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.254901 0.481252 0.621024 0.380786 0.114136 0.333252 GO:0006265 DNA topological change biological_process Clostridium Clostridium thermocellum 14.5788 104.151 68.6428 253.86 250.345 266.925 GO:0006265 DNA topological change biological_process Coprothermobacter Coprothermobacter proteolyticus 66.7647 46.8587 46.3297 31.894 34.6157 26.2064 GO:0006265 DNA topological change biological_process Escherichia Escherichia coli 0.138946 0 0.214345 0 0 0 GO:0006265 DNA topological change biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.694197 2.27184 2.63471 0.658312 0.578339 0.380984 GO:0006266 DNA ligation biological_process Escherichia Escherichia coli 0.090241 0 0.33505 0 0 0 GO:0006268 DNA unwinding involved in DNA replication biological_process Clostridium Clostridium thermocellum 2.09289 11.9003 8.03141 27.8359 27.3218 33.5524 GO:0006268 DNA unwinding involved in DNA replication biological_process Escherichia Escherichia coli 0.107813 0 0.223006 0 0 0 GO:0006268 DNA unwinding involved in DNA replication biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.585217 2.24855 2.45496 0.509663 0.383816 0.268186 GO:0006269 DNA replication, synthesis of RNA primer biological_process Clostridium Clostridium thermocellum 3.35377 23.5808 13.8349 77.6395 69.2138 68.7263 GO:0006269 DNA replication, synthesis of RNA primer biological_process Coprothermobacter Coprothermobacter proteolyticus 13.3331 9.32455 7.93813 13.0321 15.1196 9.34772 GO:0006269 DNA replication, synthesis of RNA primer biological_process Escherichia Escherichia coli 0.387115 0 0.27339 0 0 0 GO:0006270 DNA replication initiation biological_process Clostridium Clostridium thermocellum 1.62361 6.62831 5.33811 16.0679 18.1539 20.2148 GO:0006270 DNA replication initiation biological_process Coprothermobacter Coprothermobacter proteolyticus 13.1311 22.1648 29.882 8.47126 12.8847 8.72642 GO:0006270 DNA replication initiation biological_process Escherichia Escherichia coli 0.038765 0 0 0 0 0 GO:0006275 regulation of DNA replication biological_process Clostridium Clostridium thermocellum 1.62361 6.62831 5.33811 16.0679 18.1539 20.2148 GO:0006275 regulation of DNA replication biological_process Coprothermobacter Coprothermobacter proteolyticus 13.1311 22.1648 29.882 8.47126 12.8847 8.72642 GO:0006275 regulation of DNA replication biological_process Escherichia Escherichia coli 0.038765 0 0 0 0 0 GO:0006275 regulation of DNA replication biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.166118 0.159437 0.0770868 0.595043 0.519394 1.1055 GO:0006276 plasmid maintenance biological_process Escherichia Escherichia coli 0.019662 0 0 0 0 0 GO:0006281 DNA repair biological_process Clostridium Clostridium thermocellum 45.906 298.9 234.96 710.443 689.692 777.07 GO:0006281 DNA repair biological_process Coprothermobacter Coprothermobacter proteolyticus 320.905 456.174 478.26 256.124 281.123 232.373 GO:0006281 DNA repair biological_process Escherichia Escherichia coli 2.49661 0 1.30935 0 0 0.432112 GO:0006281 DNA repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.39196 3.53049 4.78845 3.00782 1.13571 2.26049 GO:0006282 regulation of DNA repair biological_process Clostridium Clostridium thermocellum 0.928925 7.51585 2.96484 14.3278 13.304 20.4789 GO:0006282 regulation of DNA repair biological_process Coprothermobacter Coprothermobacter proteolyticus 10.3306 21.2501 25.7298 8.17725 8.29694 8.41684 GO:0006284 base-excision repair biological_process Clostridium Clostridium thermocellum 9.10233 47.1933 46.9591 112.129 98.3745 179.749 GO:0006284 base-excision repair biological_process Coprothermobacter Coprothermobacter proteolyticus 35.2144 18.7453 22.4538 18.0727 28.9692 25.5127 GO:0006284 base-excision repair biological_process Escherichia Escherichia coli 0.836059 0 0.324811 0 0 0 GO:0006284 base-excision repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.152529 0.164322 0.234426 0.290624 0.375099 GO:0006285 base-excision repair, AP site formation biological_process Escherichia Escherichia coli 0.272497 0 0 0 0 0 GO:0006289 nucleotide-excision repair biological_process Clostridium Clostridium thermocellum 10.5148 35.8935 31.0746 82.8924 74.6144 84.5537 GO:0006289 nucleotide-excision repair biological_process Coprothermobacter Coprothermobacter proteolyticus 23.0826 22.3576 15.9566 24.5116 23.5278 18.7787 GO:0006289 nucleotide-excision repair biological_process Escherichia Escherichia coli 0.321834 0 0 0 0 0 GO:0006289 nucleotide-excision repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.230475 0.140161 0.308573 0.406079 0.22328 0.414002 GO:0006298 mismatch repair biological_process Clostridium Clostridium thermocellum 2.98984 19.5161 13.0179 52.0287 52.5978 53.8572 GO:0006298 mismatch repair biological_process Coprothermobacter Coprothermobacter proteolyticus 34.6387 33.8197 30.2089 39.5389 47.3924 42.4149 GO:0006298 mismatch repair biological_process Escherichia Escherichia coli 0.174187 0 0.221111 0 0 0 GO:0006298 mismatch repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.135471 1.14467 1.00474 0.277252 0.241922 0.342437 GO:0006302 double-strand break repair biological_process Clostridium Clostridium thermocellum 1.90991 12.3852 7.99226 25.3602 28.2005 32.8534 GO:0006302 double-strand break repair biological_process Escherichia Escherichia coli 0.12344 0 0 0 0 0 GO:0006302 double-strand break repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.17477 0.691003 0.0763199 0.0526003 0.109947 0.109435 GO:0006304 DNA modification biological_process Clostridium Clostridium thermocellum 0.152192 0.0224967 0.0869199 0.0359373 0.0418215 0.0934594 GO:0006304 DNA modification biological_process Coprothermobacter Coprothermobacter proteolyticus 0.0579409 0.0445266 0.107534 0.011863 0.0827749 0.0308513 GO:0006304 DNA modification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.391125 0.083988 0.277899 0 0.060215 GO:0006306 DNA methylation biological_process Clostridium Clostridium thermocellum 0.114326 1.40912 0.709748 0.0874434 0.266751 0.145299 GO:0006306 DNA methylation biological_process Coprothermobacter Coprothermobacter proteolyticus 5.46258 3.89958 3.45221 6.18637 6.63148 3.68699 GO:0006306 DNA methylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0571388 0.192062 0 0.146112 0.102004 0.132978 GO:0006307 DNA dealkylation involved in DNA repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0 0.0848896 GO:0006308 DNA catabolic process biological_process Clostridium Clostridium thermocellum 9.96534 32.9928 26.8289 117.871 107.577 100.856 GO:0006308 DNA catabolic process biological_process Escherichia Escherichia coli 0 0 0.0705914 0 0 0 GO:0006310 DNA recombination biological_process Clostridium Clostridium thermocellum 47.6532 242.043 175.334 593.376 560.301 580.451 GO:0006310 DNA recombination biological_process Coprothermobacter Coprothermobacter proteolyticus 253.594 416.12 423.563 235.223 247.802 214.524 GO:0006310 DNA recombination biological_process Escherichia Escherichia coli 3.46445 0 0.659004 0 0 0.299587 GO:0006310 DNA recombination biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.760352 0.941173 2.46962 1.61604 0.35315 1.0319 GO:0006313 transposition, DNA-mediated biological_process Clostridium Clostridium thermocellum 53.4656 226.165 197.304 382.169 366.093 416.208 GO:0006313 transposition, DNA-mediated biological_process Coprothermobacter Coprothermobacter proteolyticus 17.2546 16.0043 18.9494 12.4801 8.90857 9.72214 GO:0006313 transposition, DNA-mediated biological_process Escherichia Escherichia coli 10.6623 0 4.68705 0 0 1.63625 GO:0006313 transposition, DNA-mediated biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.123683 0.356213 0.401717 0.253103 0.386681 0.493718 GO:0006351 transcription, DNA-templated biological_process Clostridium Clostridium thermocellum 164.724 1325.19 1224.52 2960.81 2573.94 3008.1 GO:0006351 transcription, DNA-templated biological_process Coprothermobacter Coprothermobacter proteolyticus 963.689 1463.74 1175.16 759.157 866.563 813.038 GO:0006351 transcription, DNA-templated biological_process Escherichia Escherichia coli 17.9065 0 10.8492 0 0 5.91291 GO:0006351 transcription, DNA-templated biological_process Methanothermobacter Methanothermobacter thermautotrophicus 32.0609 46.0881 31.7828 49.012 19.4615 56.3162 GO:0006352 DNA-templated transcription, initiation biological_process Clostridium Clostridium thermocellum 54.2278 290.859 233.105 793.09 749.265 841.275 GO:0006352 DNA-templated transcription, initiation biological_process Coprothermobacter Coprothermobacter proteolyticus 170.255 122.214 124.81 81.1139 113.434 92.5824 GO:0006352 DNA-templated transcription, initiation biological_process Escherichia Escherichia coli 0.355301 0 0.204602 0 0 0 GO:0006352 DNA-templated transcription, initiation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.67367 7.50012 4.96851 4.06704 2.46463 4.71967 GO:0006353 DNA-templated transcription, termination biological_process Clostridium Clostridium thermocellum 37.68 219.701 171.354 521.356 508.361 568.762 GO:0006353 DNA-templated transcription, termination biological_process Coprothermobacter Coprothermobacter proteolyticus 121.719 157.281 136.164 149.221 188.105 134.129 GO:0006353 DNA-templated transcription, termination biological_process Escherichia Escherichia coli 0.123319 0 0.0812816 0 0 0.0241572 GO:0006353 DNA-templated transcription, termination biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.172364 0.331009 0 0.881596 0.460688 0.800743 GO:0006354 DNA-templated transcription, elongation biological_process Clostridium Clostridium thermocellum 11.3204 50.8585 32.9726 201.327 197.621 156.937 GO:0006354 DNA-templated transcription, elongation biological_process Coprothermobacter Coprothermobacter proteolyticus 61.4545 80.1168 56.7512 84.885 109.133 88.1916 GO:0006354 DNA-templated transcription, elongation biological_process Escherichia Escherichia coli 0.0613677 0 0 0 0 0 GO:0006355 regulation of transcription, DNA-templated biological_process Clostridium Clostridium thermocellum 150.96 1377.26 1373.87 2729.98 2518.85 3040.49 GO:0006355 regulation of transcription, DNA-templated biological_process Coprothermobacter Coprothermobacter proteolyticus 938.636 1658.44 1172.12 751.274 813.121 749.815 GO:0006355 regulation of transcription, DNA-templated biological_process Escherichia Escherichia coli 7.09773 0 3.97856 0 0 3.77544 GO:0006355 regulation of transcription, DNA-templated biological_process Methanothermobacter Methanothermobacter thermautotrophicus 9.55458 29.3612 16.6682 12.0298 8.20336 20.2803 GO:0006364 rRNA processing biological_process Clostridium Clostridium thermocellum 21.6873 150.553 106.646 400.291 363.636 400.131 GO:0006364 rRNA processing biological_process Coprothermobacter Coprothermobacter proteolyticus 109.158 93.7532 82.9219 83.8596 105.482 68.8383 GO:0006364 rRNA processing biological_process Escherichia Escherichia coli 0.261512 0 0 0 0 0.0680087 GO:0006364 rRNA processing biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.92549 2.10321 5.19553 8.02253 2.50775 6.84653 GO:0006367 transcription initiation from RNA polymerase II promoter biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.502243 3.85533 1.2821 0.642147 0.616732 1.91278 GO:0006378 mRNA polyadenylation biological_process Escherichia Escherichia coli 0 0 0.0742451 0 0 0 GO:0006379 mRNA cleavage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.64781 1.76795 0.341726 3.57145 0.822085 6.1105 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation biological_process Clostridium Clostridium thermocellum 0.801937 6.93789 6.93591 10.7004 9.95663 15.0828 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.265668 1.02598 0.991347 0.411078 0.0597915 0 GO:0006396 RNA processing biological_process Clostridium Clostridium thermocellum 25.1889 100.817 77.7341 298.521 287.296 305.909 GO:0006396 RNA processing biological_process Coprothermobacter Coprothermobacter proteolyticus 135.44 105.201 98.5433 91.8139 104.844 82.173 GO:0006396 RNA processing biological_process Escherichia Escherichia coli 0.363905 0 0.33505 0 0 0.135177 GO:0006396 RNA processing biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.884522 1.83147 2.64242 2.07016 1.054 2.3837 GO:0006397 mRNA processing biological_process Clostridium Clostridium thermocellum 1.29891 6.48698 2.88541 28.1773 22.2648 16.6507 GO:0006400 tRNA modification biological_process Clostridium Clostridium thermocellum 7.12204 59.4064 49.2044 167.6 152.573 140.148 GO:0006400 tRNA modification biological_process Coprothermobacter Coprothermobacter proteolyticus 59.3036 41.3259 25.5251 16.2168 19.669 14.5706 GO:0006400 tRNA modification biological_process Escherichia Escherichia coli 0.160018 0 0.186605 0 0 0 GO:0006400 tRNA modification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.414117 0.158737 0.461844 0.26335 0.147884 0.238047 GO:0006401 RNA catabolic process biological_process Clostridium Clostridium thermocellum 6.60254 42.4215 39.2954 125.812 115.846 91.043 GO:0006401 RNA catabolic process biological_process Escherichia Escherichia coli 0.218275 0 0.0815974 0 0 0.0966286 GO:0006401 RNA catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.13707 4.92523 4.37198 3.57137 1.55679 3.69284 GO:0006402 mRNA catabolic process biological_process Clostridium Clostridium thermocellum 71.5998 419.342 309.158 1101.61 1106.11 1239.69 GO:0006402 mRNA catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 45.006100000000004 66.6318 57.0036 41.4935 47.6957 42.4064 GO:0006402 mRNA catabolic process biological_process Escherichia Escherichia coli 0.157831 0 0 0 0 0 GO:0006412 translation biological_process Clostridium Clostridium thermocellum 1143.89 7860.87 4330.21 25293.4 22865.7 29087 GO:0006412 translation biological_process Coprothermobacter Coprothermobacter proteolyticus 7168.49 8954.82 6667.55 9784.23 11084.7 8918.76 GO:0006412 translation biological_process Escherichia Escherichia coli 2.16323 0 2.26208 0 0 1.02417 GO:0006412 translation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 28.3096 78.6725 98.6475 105.263 54.9794 86.1134 GO:0006414 translational elongation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.299178 0.578309 0.478277 1.11121 0.414617 GO:0006415 translational termination biological_process Clostridium Clostridium thermocellum 4.57116 19.918 15.7805 60.6957 72.1577 83.0681 GO:0006415 translational termination biological_process Coprothermobacter Coprothermobacter proteolyticus 29.1754 32.5188 25.8589 27.779 37.1724 34.0301 GO:0006417 regulation of translation biological_process Clostridium Clostridium thermocellum 29.5781 51.7533 27.0008 262.427 196.911 154.505 GO:0006417 regulation of translation biological_process Coprothermobacter Coprothermobacter proteolyticus 19.8934 33.9467 29.8872 33.8104 51.1115 38.6829 GO:0006417 regulation of translation biological_process Escherichia Escherichia coli 0.0640412 0 0 0 0 0.0213113 GO:0006417 regulation of translation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.54731 6.5134 2.81937 7.9523 4.54852 7.20401 GO:0006418 tRNA aminoacylation for protein translation biological_process Clostridium Clostridium thermocellum 8.44719 22.8474 17.5299 64.1393 54.8431 56.0281 GO:0006418 tRNA aminoacylation for protein translation biological_process Coprothermobacter Coprothermobacter proteolyticus 31.5281 47.8248 39.7871 44.0812 45.2613 27.3038 GO:0006418 tRNA aminoacylation for protein translation biological_process Escherichia Escherichia coli 0.0299426 0 0 0 0 0 GO:0006418 tRNA aminoacylation for protein translation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0335396 0.128866 0.0622468 0.0686415 0.02995 0.156229 GO:0006419 alanyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 5.49719 19.1865 11.5244 63.4788 64.6384 64.436 GO:0006419 alanyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 6.59223 6.15028 6.41724 6.8654 7.66215 7.15369 GO:0006419 alanyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0195891 0 0 0 0 0 GO:0006420 arginyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 14.0925 38.9658 49.3593 83.7525 86.937 71.8438 GO:0006420 arginyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 41.754 41.1333 32.755 51.7953 57.2362 34.3873 GO:0006420 arginyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.076655 0 0 0 0 0 GO:0006420 arginyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0792798 1.03517 0.646194 0.259569 0.184019 0.0843722 GO:0006421 asparaginyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.34199 16.3389 11.4461 45.0052 43.2546 38.7695 GO:0006421 asparaginyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 17.2449 20.8917 17.6842 13.8413 16.2779 15.6655 GO:0006421 asparaginyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0950045 0 0 0 0 0 GO:0006422 aspartyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0417544 0.0801853 0.154985 0.213386 0.0372856 0.138863 GO:0006423 cysteinyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 1.56572 12.2106 8.96696 28.6586 23.4713 15.921 GO:0006423 cysteinyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 13.6957 7.68243 4.86418 7.07781 9.52005 7.78834 GO:0006423 cysteinyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.039324 0 0.036491 0 0 0.0523243 GO:0006424 glutamyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 6.61953 33.0496 27.0863 99.7149 103.601 83.1163 GO:0006424 glutamyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1668 7.405 5.89757 6.48456 9.30782 6.88159 GO:0006424 glutamyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0384004 0 0 0 0 0 GO:0006424 glutamyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0321543 0.308746 0.0596757 0 0.0574259 0 GO:0006425 glutaminyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.33414 19.5644 13.4457 57.1243 62.2455 49.6799 GO:0006426 glycyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 4.03843 22.7861 16.3044 71.33 61.2833 62.8522 GO:0006426 glycyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 16.6999 6.40707 6.34443 9.92818 11.3027 9.74119 GO:0006426 glycyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.334229 0 0 0 0 0 GO:0006426 glycyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.0904535 0.349394 0.176727 0.0701004 0.0835637 GO:0006427 histidyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.63978 11.8759 8.04715 27.4492 23.7777 26.3258 GO:0006427 histidyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 13.6129 19.4776 14.613 22.3125 23.2156 14.0687 GO:0006427 histidyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0432126 0 0 0 0 0.0287493 GO:0006427 histidyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.307325 0.866309 0.228328 0.209879 0.256377 0.327464 GO:0006428 isoleucyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 55.1984 36.1391 27.3652 30.631 32.1575 26.0457 GO:0006428 isoleucyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.00911402 0 0.0338298 0 0 0 GO:0006428 isoleucyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0977023 0.156263 0.120885 0.13308 0.0581638 0.173336 GO:0006429 leucyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 5.48015 36.422 27.236 91.0435 87.979 79.0557 GO:0006429 leucyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 29.2374 12.0659 12.6704 13.3937 15.282 10.5045 GO:0006429 leucyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0199779 0 0 0 0 0.0265826 GO:0006429 leucyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.209841 0.140161 0.237034 0.140044 0.105889 0.169909 GO:0006430 lysyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 1.45601 14.2331 9.50287 38.4728 37.9494 40.2274 GO:0006430 lysyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 37.675 31.0372 19.2826 53.2743 51.8031 42.9871 GO:0006430 lysyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.112236 0 0.0659455 0 0 0.046471 GO:0006430 lysyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0981884 0.125739 0.121517 0.100475 0.0292338 0 GO:0006431 methionyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.43692 9.97597 6.73366 33.4126 30.0803 23.122 GO:0006431 methionyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 24.9197 13.0987 14.9571 14.1977 14.6997 10.6684 GO:0006431 methionyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0386921 0 0 0 0 0 GO:0006431 methionyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.103382 0.049932699999999997 0.275362 0.120169 0.143261 GO:0006432 phenylalanyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 1.97312 28.3832 22.7411 42.6145 37.7424 32.7753 GO:0006432 phenylalanyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 42.5364 32.6279 31.8027 38.7024 45.6252 27.2614 GO:0006432 phenylalanyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0434313 0 0.0540825 0 0 0 GO:0006432 phenylalanyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.153869 0.502441 0.12517 0.486012 0.204919 0.40194 GO:0006433 prolyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.52422 18.083 14.3411 44.9913 40.6442 43.3146 GO:0006433 prolyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 21.8478 24.8163 15.5358 30.7611 38.881100000000004 29.2867 GO:0006433 prolyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0309634 0 0 0 0 0 GO:0006433 prolyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0748079 0.143708 0.138837 0.228929 0.133603 0.0993774 GO:0006434 seryl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.40476 16.8858 13.3064 39.3101 43.4919 37.9766 GO:0006434 seryl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 7.1783 5.77516 2.36222 9.40884 9.56265 9.14085 GO:0006434 seryl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0212417 0 0 0 0 0 GO:0006434 seryl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.139675 0.167605 0.22675 0.303739 0.15587 0.232323 GO:0006435 threonyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 4.03547 29.0893 18.9049 72.3296 67.5599 52.1923 GO:0006435 threonyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 50.5135 73.2095 59.1197 59.8116 67.3875 40.0379 GO:0006435 threonyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0 0 0.0499778 0 0 0 GO:0006435 threonyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.116562 0.167885 0.162248 0.208735 0.117087 0.387776 GO:0006436 tryptophanyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 2.31474 19.8864 9.66349 46.4333 46.0442 41.3628 GO:0006436 tryptophanyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 13.7707 13.9259 10.8528 20.4638 22.8987 18.5213 GO:0006436 tryptophanyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.113597 0 0 0 0 0 GO:0006436 tryptophanyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.154209 0.395045 0.28638 0.39444 0.137792 0.0684291 GO:0006437 tyrosyl-tRNA aminoacylation biological_process Clostridium Clostridium thermocellum 0.924769 11.7781 8.03421 31.9374 31.988 25.6617 GO:0006437 tyrosyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 1.46072 1.20339 1.41855 1.02027 1.26406 0.678696 GO:0006437 tyrosyl-tRNA aminoacylation biological_process Escherichia Escherichia coli 0.0432126 0 0 0 0 0 GO:0006437 tyrosyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0300155 0.230474 0.111368 0.0307146 0.0535845 0.239437 GO:0006438 valyl-tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 52.0003 32.0423 38.9351 29.4323 33.8191 26.451 GO:0006438 valyl-tRNA aminoacylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.038206 0.348559 0.0354536 0.215052 0.12796 0.127124 GO:0006449 regulation of translational termination biological_process Clostridium Clostridium thermocellum 0.853583 3.40601 1.55301 10.2901 11.8347 12.735900000000001 GO:0006449 regulation of translational termination biological_process Escherichia Escherichia coli 0.033734 0 0.0626527 0 0 0.0224432 GO:0006450 regulation of translational fidelity biological_process Clostridium Clostridium thermocellum 1.23156 5.96101 4.87076 16.4469 20.2092 20.5046 GO:0006450 regulation of translational fidelity biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.230816 0.0805587 0 0.128802 0.0562323 0.0837254 GO:0006452 translational frameshifting biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.299645 1.15242 0 0.920692 0.356883 1.19719 GO:0006457 protein folding biological_process Clostridium Clostridium thermocellum 31.557 350.892 344.238 606.168 625.807 632.404 GO:0006457 protein folding biological_process Coprothermobacter Coprothermobacter proteolyticus 252.525 156.135 227.791 102.427 149.864 181.694 GO:0006457 protein folding biological_process Escherichia Escherichia coli 0.255654 0 0.40519 0 0 0.0530681 GO:0006457 protein folding biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.22132 10.3413 10.4654 4.46938 4.56573 9.31994 GO:0006461 protein complex assembly biological_process Clostridium Clostridium thermocellum 0.413995 2.15095 2.25884 18.9885 10.7841 9.65254 GO:0006461 protein complex assembly biological_process Coprothermobacter Coprothermobacter proteolyticus 11.1449 13.6771 5.03229 7.06966 9.38825 10.6529 GO:0006461 protein complex assembly biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.185201 0.357829 0.788656 0.0861172 0.256674 GO:0006464 cellular protein modification process biological_process Clostridium Clostridium thermocellum 0.217497 2.60971 0.706365 3.28263 1.65025 7.94968 GO:0006464 cellular protein modification process biological_process Coprothermobacter Coprothermobacter proteolyticus 166.619 216.391 385.592 107.014 124.807 102.897 GO:0006464 cellular protein modification process biological_process Escherichia Escherichia coli 0.717772 0 0.0994144 0 0 0 GO:0006464 cellular protein modification process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 3.51869 3.01918 5.77853 3.45685 3.36187 2.86076 GO:0006465 signal peptide processing biological_process Escherichia Escherichia coli 0.0846024 0 0 0 0 0.0379012 GO:0006465 signal peptide processing biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.340816 0.979772 0.316556 0.261783 0.0761555 0.113477 GO:0006468 protein phosphorylation biological_process Escherichia Escherichia coli 0.120597 0 0 0 0 0 GO:0006470 protein dephosphorylation biological_process Escherichia Escherichia coli 0.242652 0 0.177945 0 0 0 GO:0006474 N-terminal protein amino acid acetylation biological_process Clostridium Clostridium thermocellum 0.863936 4.81023 4.66521 16.7138 12.776 11.1884 GO:0006474 N-terminal protein amino acid acetylation biological_process Coprothermobacter Coprothermobacter proteolyticus 7.87636 3.88773 3.60458 1.22769 3.346 1.58729 GO:0006474 N-terminal protein amino acid acetylation biological_process Escherichia Escherichia coli 0.0736413 0 0.135454 0 0 0 GO:0006474 N-terminal protein amino acid acetylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.227146 0.435745 0 0.309907 0.202835 0.20118 GO:0006479 protein methylation biological_process Escherichia Escherichia coli 0.150126 0 0 0 0 0 GO:0006486 protein glycosylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.228774 0.391592 0.231305 0.153225 0.327671 0.202312 GO:0006493 protein O-linked glycosylation biological_process Clostridium Clostridium thermocellum 2.50346 4.38419 2.69903 22.4856 20.2827 17.4859 GO:0006493 protein O-linked glycosylation biological_process Escherichia Escherichia coli 0.0323487 0 0.0586834 0 0 0 GO:0006508 proteolysis biological_process Clostridium Clostridium thermocellum 0.486081 5.91 2.38342 6.28965 5.7809 15.2818 GO:0006508 proteolysis biological_process Escherichia Escherichia coli 1.45693 0 0.846285 0 0 0.170717 GO:0006511 ubiquitin-dependent protein catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.488463 0.781783 0.453319 0.166505 0.217876 1.0818 GO:0006515 misfolded or incompletely synthesized protein catabolic process biological_process Clostridium Clostridium thermocellum 3.384 11.554 11.2844 33.3054 26.5787 30.8817 GO:0006515 misfolded or incompletely synthesized protein catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 14.3745 14.8853 9.86895 18.6179 26.4482 29.9665 GO:0006515 misfolded or incompletely synthesized protein catabolic process biological_process Escherichia Escherichia coli 0.194675 0 0.218766 0 0 0.0530681 GO:0006520 cellular amino acid metabolic process biological_process Clostridium Clostridium thermocellum 4.75844 179.434 126.828 508.831 598.8 832.114 GO:0006520 cellular amino acid metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 93.957 92.2553 107.802 72.9845 92.6523 81.1496 GO:0006520 cellular amino acid metabolic process biological_process Escherichia Escherichia coli 0.51668 0 0.322285 0 0 0 GO:0006520 cellular amino acid metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.603664 0.353553 0.430044 0.305778 0.265665 0.88518 GO:0006522 alanine metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.111701 0.321908 0.103745 0 0.124727 0.0743471 GO:0006523 alanine biosynthetic process biological_process Clostridium Clostridium thermocellum 2.52193 14.4972 11.4945 32.9542 31.4178 34.2164 GO:0006523 alanine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 29.9563 26.9304 27.2579 21.9174 19.4253 18.9558 GO:0006523 alanine biosynthetic process biological_process Escherichia Escherichia coli 0.0446465 0 0 0 0 0 GO:0006525 arginine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 82.2044 17.393 23.6271 27.2268 30.7455 22.1183 GO:0006525 arginine metabolic process biological_process Escherichia Escherichia coli 0.260928 0 0 0 0 0 GO:0006526 arginine biosynthetic process biological_process Clostridium Clostridium thermocellum 7.94956 35.4299 30.2387 135.449 101.166 96.0519 GO:0006526 arginine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 110.225 64.4571 68.7743 37.0576 48.5997 48.8203 GO:0006526 arginine biosynthetic process biological_process Escherichia Escherichia coli 0.439563 0 0.139694 0 0 0.103581 GO:0006526 arginine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.20966 2.4042 1.89032 1.493 1.21436 3.2715 GO:0006527 arginine catabolic process biological_process Escherichia Escherichia coli 0.0887584 0 0.0493915 0 0 0 GO:0006527 arginine catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.305059 0.147408 0 0 0 GO:0006528 asparagine metabolic process biological_process Escherichia Escherichia coli 0.135471 0 0.0502936 0 0 0.0360579 GO:0006529 asparagine biosynthetic process biological_process Clostridium Clostridium thermocellum 0.0574548 0.220626 0.106631 0.26422 0.205223 0.324909 GO:0006529 asparagine biosynthetic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.452292 GO:0006529 asparagine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0771897 0.074071 0.286425 0.176802 0.0344425 0.256641 GO:0006531 aspartate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.274417 0.316447 0.10176 0.224826 0.637198 0.219193 GO:0006531 aspartate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.244572 0.104409 0.756839 0.862297 0.194176 0.506492 GO:0006535 cysteine biosynthetic process from serine biological_process Clostridium Clostridium thermocellum 9.21889 942.806 640.11 1470.31 1286.49 1136.76 GO:0006535 cysteine biosynthetic process from serine biological_process Coprothermobacter Coprothermobacter proteolyticus 6.37537 20.7263 18.0253 14.2907 15.7527 11.2618 GO:0006535 cysteine biosynthetic process from serine biological_process Escherichia Escherichia coli 0.0662285 0 0.109744 0 0 0 GO:0006536 glutamate metabolic process biological_process Escherichia Escherichia coli 0.27867 0 0 0 0 0.0517099 GO:0006537 glutamate biosynthetic process biological_process Clostridium Clostridium thermocellum 0.0358485 4.2676 11.7037 15.034 23.2169 30.3742 GO:0006537 glutamate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 8.8536 7.17812 8.30773 2.55001 3.206 4.34188 GO:0006537 glutamate biosynthetic process biological_process Escherichia Escherichia coli 0.133259 0 0.113894 0 0 0 GO:0006537 glutamate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.295076 0.463002 0.367572 1.10774 0.474339 0.297194 GO:0006541 glutamine metabolic process biological_process Clostridium Clostridium thermocellum 18.3298 83.207 52.1163 271.671 262.208 228.773 GO:0006541 glutamine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 153.962 75.4199 72.4702 69.8816 83.9803 51.9815 GO:0006541 glutamine metabolic process biological_process Escherichia Escherichia coli 0.487029 0 0.0439787 0 0 0.146657 GO:0006541 glutamine metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.04323 2.65503 2.14445 2.96146 1.79075 3.39332 GO:0006542 glutamine biosynthetic process biological_process Clostridium Clostridium thermocellum 1.24208 10.5026 19.1823 47.285 51.3849 47.0985 GO:0006542 glutamine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 89.8945 66.5803 94.2909 35.8416 41.9936 38.8995 GO:0006542 glutamine biosynthetic process biological_process Escherichia Escherichia coli 0.212272 0 0 0 0 0 GO:0006542 glutamine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.12344 0.0791584 0.229546 0.126465 0.0368081 0.164573 GO:0006543 glutamine catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.652544 0.420797 1.67843 0.202358 1.1316 GO:0006544 glycine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 33.2716 51.5545 66.8396 27.4989 35.3101 21.7446 GO:0006545 glycine biosynthetic process biological_process Clostridium Clostridium thermocellum 4.66723 34.7584 21.8931 95.8256 97.9612 69.4259 GO:0006555 methionine metabolic process biological_process Clostridium Clostridium thermocellum 0.220584 3.75139 3.04175 10.2494 9.54049 13.2489 GO:0006555 methionine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.722657 0.346785 0.335366 0.154046 0.484084 0.24044 GO:0006556 S-adenosylmethionine biosynthetic process biological_process Clostridium Clostridium thermocellum 2.44273 25.2447 17.4504 80.409 108.614 87.4991 GO:0006556 S-adenosylmethionine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 27.8182 10.2815 7.51373 26.666 34.968 18.8696 GO:0006556 S-adenosylmethionine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.13462 0.215492 0.0833114 0.183691 0.320661 0.298617 GO:0006557 S-adenosylmethioninamine biosynthetic process biological_process Clostridium Clostridium thermocellum 17.8211 150.459 93.7517 655.139 644.823 950.994 GO:0006557 S-adenosylmethioninamine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 91.4887 110.189 143.464 72.4909 93.239 81.7297 GO:0006557 S-adenosylmethioninamine biosynthetic process biological_process Escherichia Escherichia coli 0 0 0.0699148 0 0 0.0501253 GO:0006561 proline biosynthetic process biological_process Clostridium Clostridium thermocellum 0.540085 2.86455 2.88893 11.9237 4.87905 5.78973 GO:0006561 proline biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 40.8268 47.4838 37.6034 33.4503 33.3063 29.2921 GO:0006561 proline biosynthetic process biological_process Escherichia Escherichia coli 0.00636766 0 0 0 0 0 GO:0006561 proline biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.371609 0.127419 0.332163 0.366237 0.308116 0.511892 GO:0006564 L-serine biosynthetic process biological_process Clostridium Clostridium thermocellum 3.83627 38.8084 29.9703 82.1011 81.3638 64.717 GO:0006564 L-serine biosynthetic process biological_process Escherichia Escherichia coli 0.0224326 0 0.206136 0 0 0 GO:0006564 L-serine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.179121 0.675647 0.395673 0.451492 0.722751 1.06285 GO:0006569 tryptophan catabolic process biological_process Escherichia Escherichia coli 0.221993 0 0.199641 0 0 0.134886 GO:0006570 tyrosine metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0258109 0.148609 0 0.369296 0.115025 0 GO:0006571 tyrosine biosynthetic process biological_process Clostridium Clostridium thermocellum 3.38371 16.3874 12.5114 61.2005 62.8299 58.0045 GO:0006571 tyrosine biosynthetic process biological_process Escherichia Escherichia coli 0.0698499 0 0 0 0 0 GO:0006571 tyrosine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.2427 0.544541 0.41349 0.496905 0.289343 0.565963 GO:0006593 ornithine catabolic process biological_process Escherichia Escherichia coli 0.0680757 0 0 0 0 0 GO:0006605 protein targeting biological_process Clostridium Clostridium thermocellum 49.1403 203.27 133.526 944.343 781.244 838.359 GO:0006605 protein targeting biological_process Coprothermobacter Coprothermobacter proteolyticus 229.033 209.599 183.924 204.744 292.953 237.531 GO:0006605 protein targeting biological_process Escherichia Escherichia coli 0.130464 0 0.283087 0 0 0.0273587 GO:0006605 protein targeting biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.479884 0.348138 0.905871 0.768238 0.663957 0.866585 GO:0006614 SRP-dependent cotranslational protein targeting to membrane biological_process Clostridium Clostridium thermocellum 5.75785 37.1508 25.7878 104.476 103.333 103.266 GO:0006614 SRP-dependent cotranslational protein targeting to membrane biological_process Coprothermobacter Coprothermobacter proteolyticus 22.7115 17.1426 18.7198 10.9277 14.4437 12.0794 GO:0006614 SRP-dependent cotranslational protein targeting to membrane biological_process Escherichia Escherichia coli 0.0181551 0 0 0 0 0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.32231 0.877791 1.02031 1.39887 1.12061 0.698649 GO:0006627 protein processing involved in protein targeting to mitochondrion biological_process Clostridium Clostridium thermocellum 2.75139 29.8022 17.9531 85.0748 71.176 68.1265 GO:0006629 lipid metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 83.4374 87.955 117.991 64.8213 72.8441 53.7094 GO:0006629 lipid metabolic process biological_process Escherichia Escherichia coli 0.118312 0 0 0 0 0 GO:0006629 lipid metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.359773 0.138901 0.335591 0.147927 0.0322939 0 GO:0006631 fatty acid metabolic process biological_process Escherichia Escherichia coli 0.222188 0 0 0 0 0.0960142 GO:0006633 fatty acid biosynthetic process biological_process Clostridium Clostridium thermocellum 37.526 210.249 125.572 805.318 642.782 578.118 GO:0006633 fatty acid biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 289.769 157.706 129.753 180.723 215.893 161.83 GO:0006633 fatty acid biosynthetic process biological_process Escherichia Escherichia coli 0.172559 0 0.966629 0 0 0.0539089 GO:0006635 fatty acid beta-oxidation biological_process Escherichia Escherichia coli 0.194262 0 0.0881829 0 0 0.0158461 GO:0006641 triglyceride metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0006646 phosphatidylethanolamine biosynthetic process biological_process Escherichia Escherichia coli 0.0296752 0 0 0 0 0 GO:0006646 phosphatidylethanolamine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.35766 0.172802 0.19058 0.415611 0.803427 GO:0006650 glycerophospholipid metabolic process biological_process Clostridium Clostridium thermocellum 1.81461 8.36484 5.49274 33.4607 32.5297 24.5134 GO:0006650 glycerophospholipid metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.14437 4.0171 3.62457 3.57142 2.38044 3.65433 GO:0006655 phosphatidylglycerol biosynthetic process biological_process Escherichia Escherichia coli 0.060906 0 0.244476 0 0 0.175277 GO:0006662 glycerol ether metabolic process biological_process Clostridium Clostridium thermocellum 38.8844 434.038 334.012 974.87 757.718 1469.5 GO:0006662 glycerol ether metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 66.74 167.601 230.571 124.749 143.671 96.3272 GO:0006662 glycerol ether metabolic process biological_process Escherichia Escherichia coli 0.0685131 0 0 0 0 0 GO:0006662 glycerol ether metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.450087 2.58903 0.41764 0.690842 0.801966 1.19499 GO:0006665 sphingolipid metabolic process biological_process Clostridium Clostridium thermocellum 1.10134 2.62324 4.47595 5.63485 5.90085 6.5278 GO:0006725 cellular aromatic compound metabolic process biological_process Clostridium Clostridium thermocellum 6.5338 41.5837 28.6976 66.6847 86.606 106.486 GO:0006725 cellular aromatic compound metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 62.4891 45.4467 49.2424 37.3337 55.9564 46.8678 GO:0006725 cellular aromatic compound metabolic process biological_process Escherichia Escherichia coli 0.109417 0 0 0 0 0 GO:0006725 cellular aromatic compound metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.14213 0.272947 0.263692 1.65272 0.0317297 0 GO:0006730 one-carbon metabolic process biological_process Clostridium Clostridium thermocellum 9.85743 229.335 225.962 278.674 300.875 271.853 GO:0006730 one-carbon metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 44.7513 32.178 26.851 55.7994 72.6024 40.7809 GO:0006730 one-carbon metabolic process biological_process Escherichia Escherichia coli 0.0654265 0 0.365136 0 0 0 GO:0006730 one-carbon metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 40.6945 18.8299 54.8542 42.8272 37.4459 71.7083 GO:0006734 NADH metabolic process biological_process Escherichia Escherichia coli 0.0330049 0 0 0 0 0 GO:0006739 NADP metabolic process biological_process Escherichia Escherichia coli 0.0953691 0 0.07208 0 0 0.0517099 GO:0006740 NADPH regeneration biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.339924 0.246461 0 0.276647 0.0588891 GO:0006741 NADP biosynthetic process biological_process Clostridium Clostridium thermocellum 3.27337 43.3958 38.1945 99.6322 94.2849 136.194 GO:0006741 NADP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 30.4671 40.6183 32.4355 23.0473 31.7517 24.0679 GO:0006741 NADP biosynthetic process biological_process Escherichia Escherichia coli 0.233368 0 0 0 0 0 GO:0006741 NADP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.207727 0.398826 0.192649 0.070855 0.15459 0 GO:0006744 ubiquinone biosynthetic process biological_process Clostridium Clostridium thermocellum 9.60649 78.6496 60.5386 280.636 190.9 185.378 GO:0006744 ubiquinone biosynthetic process biological_process Escherichia Escherichia coli 0.267418 0 0.122915 0 0 0.154774 GO:0006744 ubiquinone biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.173288 0.290917 0.321247 0.177324 0.0580336 0.0576602 GO:0006747 FAD biosynthetic process biological_process Clostridium Clostridium thermocellum 2.18476 13.2453 14.3414 40.3507 33.9304 35.5191 GO:0006747 FAD biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.502 12.0994 6.78476 11.8856 12.0771 13.8432 GO:0006747 FAD biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0794256 0.457588 0.588683 1.70599 0.70834 0.422734 GO:0006749 glutathione metabolic process biological_process Escherichia Escherichia coli 0.227364 0 0.0750119 0 0 0 GO:0006750 glutathione biosynthetic process biological_process Clostridium Clostridium thermocellum 0 1.46588 1.69992 1.48547 0.477746 0.915255 GO:0006750 glutathione biosynthetic process biological_process Escherichia Escherichia coli 0.0455458 0 0 0 0 0 GO:0006772 thiamine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 5.52963 3.21931 2.74946 2.52561 2.69027 2.35556 GO:0006777 Mo-molybdopterin cofactor biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 121.76 47.0808 42.6733 35.536 42.2358 31.167 GO:0006777 Mo-molybdopterin cofactor biosynthetic process biological_process Escherichia Escherichia coli 0.272594 0 0.329637 0 0 0.0743471 GO:0006777 Mo-molybdopterin cofactor biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.07089 2.3671 1.79041 4.05542 1.54603 3.54971 GO:0006779 porphyrin-containing compound biosynthetic process biological_process Clostridium Clostridium thermocellum 1.10579 177.859 180.352 89.2808 88.7406 94.6287 GO:0006779 porphyrin-containing compound biosynthetic process biological_process Escherichia Escherichia coli 0.377636 0 0.173569 0 0 0 GO:0006779 porphyrin-containing compound biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.301954 0.655951 0.0781693 0.570197 0.664196 0.752138 GO:0006782 protoporphyrinogen IX biosynthetic process biological_process Clostridium Clostridium thermocellum 0.52645 14.6026 15.6358 31.3887 23.3237 22.4876 GO:0006782 protoporphyrinogen IX biosynthetic process biological_process Escherichia Escherichia coli 0.329223 0 0.429232 0 0 0 GO:0006782 protoporphyrinogen IX biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.509875 1.31531 2.35099 1.19889 0.689805 1.33223 GO:0006783 heme biosynthetic process biological_process Escherichia Escherichia coli 0.149008 0 0.109338 0 0 0 GO:0006790 sulfur compound metabolic process biological_process Escherichia Escherichia coli 0.189596 0 0 0 0 0 GO:0006793 phosphorus metabolic process biological_process Escherichia Escherichia coli 0.0349249 0 0.0648178 0 0 0 GO:0006796 phosphate-containing compound metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.122518 0 0.19547900000000001 0.170889 0.169747 GO:0006805 xenobiotic metabolic process biological_process Escherichia Escherichia coli 0.431008 0 0 0 0 0 GO:0006807 nitrogen compound metabolic process biological_process Clostridium Clostridium thermocellum 1.91424 18.0432 28.1874 80.3704 75.4314 96.7531 GO:0006807 nitrogen compound metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 68.7203 92.6506 77.1084 82.9228 92.4925 80.5627 GO:0006807 nitrogen compound metabolic process biological_process Escherichia Escherichia coli 0.20797 0 0.141183 0 0 0.101221 GO:0006807 nitrogen compound metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.134733 0.631801 0.129762 0 GO:0006808 regulation of nitrogen utilization biological_process Clostridium Clostridium thermocellum 29.5502 131.469 92.9205 281.49 268.928 416.262 GO:0006808 regulation of nitrogen utilization biological_process Escherichia Escherichia coli 0.134815 0 0.0358144 0 0 0 GO:0006808 regulation of nitrogen utilization biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.642259 1.17865 0.205956 0.531599 0.464442 1.83536 GO:0006810 transport biological_process Clostridium Clostridium thermocellum 126.041 523.997 464.856 1379.54 1287.84 1186.42 GO:0006810 transport biological_process Coprothermobacter Coprothermobacter proteolyticus 1622.31 749.489 1107.24 532.472 668.228 543.656 GO:0006810 transport biological_process Escherichia Escherichia coli 2.83757 0 2.04332 0 0 0.751912 GO:0006810 transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.49299 3.65851 3.28478 4.16726 2.65761 4.40695 GO:0006811 ion transport biological_process Escherichia Escherichia coli 1.85792 0 1.65283 0 0 0.833373 GO:0006813 potassium ion transport biological_process Clostridium Clostridium thermocellum 0.298211 3.37077 2.55194 7.38812 7.07064 9.19162 GO:0006813 potassium ion transport biological_process Coprothermobacter Coprothermobacter proteolyticus 58.6051 41.5047 41.8137 28.3159 34.0254 28.5067 GO:0006813 potassium ion transport biological_process Escherichia Escherichia coli 0.626802 0 0.261166 0 0 0.120139 GO:0006813 potassium ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.692204 1.49407 0.948541 2.37574 0.798038 1.33123 GO:0006814 sodium ion transport biological_process Clostridium Clostridium thermocellum 5.74186 19.6854 17.1418 81.1865 67.3804 47.0333 GO:0006814 sodium ion transport biological_process Coprothermobacter Coprothermobacter proteolyticus 45.0709 41.4527 36.131100000000004 39.6496 43.8495 39.3051 GO:0006814 sodium ion transport biological_process Escherichia Escherichia coli 1.47173 0 0.0728919 0 0 0.0506427 GO:0006814 sodium ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 4.65863 2.91715 9.59719 11.576 11.255 11.281 GO:0006817 phosphate ion transport biological_process Clostridium Clostridium thermocellum 2.90847 19.9349 16.6952 32.2327 38.368 43.4403 GO:0006817 phosphate ion transport biological_process Coprothermobacter Coprothermobacter proteolyticus 90.0587 23.2862 17.7497 20.0183 25.6122 19.0488 GO:0006817 phosphate ion transport biological_process Escherichia Escherichia coli 0.180774 0 0.310332 0 0 0.240666 GO:0006817 phosphate ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.379945 0.730255 1.63592 1.10871 0.585046 1.07029 GO:0006820 anion transport biological_process Escherichia Escherichia coli 0.0715025 0 0.484532 0 0 0 GO:0006824 cobalt ion transport biological_process Clostridium Clostridium thermocellum 4.31181 28.5606 28.0658 49.5695 39.6386 32.0258 GO:0006824 cobalt ion transport biological_process Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0.0478292 GO:0006824 cobalt ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0701415 0.118691 0.390531 0.452686 0.0626346 0.561953 GO:0006825 copper ion transport biological_process Clostridium Clostridium thermocellum 9.2649 157.246 73.6162 357.928 224.203 535.128 GO:0006825 copper ion transport biological_process Escherichia Escherichia coli 0.00814186 0 0 0 0 0 GO:0006826 iron ion transport biological_process Clostridium Clostridium thermocellum 6.25628 115.39 79.7483 294.479 169.316 373.564 GO:0006826 iron ion transport biological_process Coprothermobacter Coprothermobacter proteolyticus 62.6168 22.0141 74.5188 8.50255 16.5574 18.8664 GO:0006826 iron ion transport biological_process Escherichia Escherichia coli 0.139675 0 0.660312 0 0 0.228507 GO:0006826 iron ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.398416 0 0.246461 0.203661 0 0 GO:0006829 zinc II ion transport biological_process Escherichia Escherichia coli 0.708001 0 0.311144 0 0 0 GO:0006835 dicarboxylic acid transport biological_process Escherichia Escherichia coli 0.10441 0 0.0387464 0 0 0 GO:0006855 drug transmembrane transport biological_process Escherichia Escherichia coli 0.501247 0 0.178802 0 0 0.0780984 GO:0006858 extracellular transport biological_process Escherichia Escherichia coli 0 0 0.466219 0 0 0.103646 GO:0006865 amino acid transport biological_process Clostridium Clostridium thermocellum 0.86763 4.62619 3.22208 16.2786 12.353 21.5471 GO:0006865 amino acid transport biological_process Coprothermobacter Coprothermobacter proteolyticus 81.1355 2.4807 4.76494 2.9156 3.13553 2.95316 GO:0006865 amino acid transport biological_process Escherichia Escherichia coli 1.41428 0 0.360851 0 0 0.584914 GO:0006865 amino acid transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.195469 0 0.10428 0 0.271194 GO:0006869 lipid transport biological_process Escherichia Escherichia coli 0.173069 0 0 0 0 0 GO:0006874 cellular calcium ion homeostasis biological_process Escherichia Escherichia coli 0.0880536 0 0 0 0 0 GO:0006879 cellular iron ion homeostasis biological_process Clostridium Clostridium thermocellum 6.25628 115.39 79.7483 294.479 169.316 373.564 GO:0006879 cellular iron ion homeostasis biological_process Coprothermobacter Coprothermobacter proteolyticus 236.703 159.995 199.796 179.002 193.502 146.835 GO:0006879 cellular iron ion homeostasis biological_process Escherichia Escherichia coli 0.2855 0 0.660312 0 0 0.300461 GO:0006879 cellular iron ion homeostasis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.25642 0.1768 0.246461 0.297869 0.0822106 0.726687 GO:0006885 regulation of pH biological_process Escherichia Escherichia coli 0.0955635 0 0.177403 0 0 0 GO:0006935 chemotaxis biological_process Clostridium Clostridium thermocellum 39.9011 153.227 121.301 1091.54 990.623 840.94 GO:0006935 chemotaxis biological_process Coprothermobacter Coprothermobacter proteolyticus 36.7895 23.57 28.1773 7.00877 10.335 10.4379 GO:0006935 chemotaxis biological_process Escherichia Escherichia coli 0.261828 0 0.113623 0 0 0.248654 GO:0006950 response to stress biological_process Clostridium Clostridium thermocellum 13.0814 162.03 293.87 116.541 163.317 222.705 GO:0006950 response to stress biological_process Escherichia Escherichia coli 0.385365 0 0.425443 0 0 0.0942679 GO:0006950 response to stress biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.26432 5.3733 5.97118 5.52763 3.27925 4.85112 GO:0006970 response to osmotic stress biological_process Escherichia Escherichia coli 0.398416 0 0 0 0 0 GO:0006972 hyperosmotic response biological_process Escherichia Escherichia coli 0.0460319 0 0 0 0 0 GO:0006974 cellular response to DNA damage stimulus biological_process Escherichia Escherichia coli 5.0368 0 2.84125 0 0 1.53086 GO:0006979 response to oxidative stress biological_process Clostridium Clostridium thermocellum 16.883 200.229 148.232 506.966 347.335 664.317 GO:0006979 response to oxidative stress biological_process Coprothermobacter Coprothermobacter proteolyticus 33.573 20.5479 34.6584 24.9246 33.2927 30.7519 GO:0006979 response to oxidative stress biological_process Escherichia Escherichia coli 1.7608 0 0.323773 0 0 0.506395 GO:0006979 response to oxidative stress biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.562542 0.259319 0.250611 0.162278 0 0.106039 GO:0007049 cell cycle biological_process Clostridium Clostridium thermocellum 87.6465 623.172 492.517 1658.04 1523.41 1746.42 GO:0007049 cell cycle biological_process Coprothermobacter Coprothermobacter proteolyticus 297.796 313.98 266.957 271.272 297.044 221.046 GO:0007049 cell cycle biological_process Escherichia Escherichia coli 1.82285 0 0.593464 0 0 0.632937 GO:0007049 cell cycle biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.110778 0.060769 0.117502 0.145714 0.0847716 0.126316 GO:0007059 chromosome segregation biological_process Clostridium Clostridium thermocellum 6.72379 45.7892 39.4453 121.488 116.209 186.388 GO:0007059 chromosome segregation biological_process Coprothermobacter Coprothermobacter proteolyticus 17.2546 16.0043 18.9494 12.4801 8.90857 9.72214 GO:0007059 chromosome segregation biological_process Escherichia Escherichia coli 0.279472 0 0.0112766 0 0 0 GO:0007059 chromosome segregation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.123683 0.356213 0.401717 0.253103 0.386681 0.493718 GO:0007062 sister chromatid cohesion biological_process Escherichia Escherichia coli 0.0836546 0 0 0 0 0 GO:0007155 cell adhesion biological_process Clostridium Clostridium thermocellum 4.5617 21.9151 16.9857 121.04 115.348 113.012 GO:0007155 cell adhesion biological_process Escherichia Escherichia coli 2.14184 0 1.28882 0 0 0.662333 GO:0007155 cell adhesion biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.296339 0.31612 0 0.269493 0.176445 0.131458 GO:0007165 signal transduction biological_process Clostridium Clostridium thermocellum 0.354013 0.723114 0.509972 3.33183 2.72595 2.76181 GO:0007165 signal transduction biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0235751 GO:0007186 G-protein coupled receptor signaling pathway biological_process Escherichia Escherichia coli 0.361523 0 0.379841 0 0 0.0899345 GO:0007446 imaginal disc growth biological_process Clostridium Clostridium thermocellum 0.844128 1.36483 0.989498 14.7573 12.6659 10.6787 GO:0007446 imaginal disc growth biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0151414 0.116311 0.168608 0.123953 0.0946464 0.362616 GO:0007608 sensory perception of smell biological_process Escherichia Escherichia coli 0.361523 0 0.379841 0 0 0.0899345 GO:0008026 ATP-dependent helicase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0605657 0.0581553 0.22481 0.108459 0.0809953 0.181324 GO:0008033 tRNA processing biological_process Clostridium Clostridium thermocellum 8.31952 51.1094 43.9072 135.764 123.42 117.665 GO:0008033 tRNA processing biological_process Coprothermobacter Coprothermobacter proteolyticus 37.0863 31.6207 25.6656 32.4106 35.0013 24.7912 GO:0008033 tRNA processing biological_process Escherichia Escherichia coli 0.480637 0 0.182185 0 0 0 GO:0008033 tRNA processing biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.579141 0.828223 1.13497 0.876174 0.548867 1.08604 GO:0008047 enzyme activator activity molecular_function Escherichia Escherichia coli 0.0704575 0 0 0 0 0 GO:0008047 enzyme activator activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.15724 1.42733 6.11376 1.58348 2.86908 1.84513 GO:0008073 ornithine decarboxylase inhibitor activity molecular_function Escherichia Escherichia coli 0.0983099 0 0.072937 0 0 0 GO:0008080 N-acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 31.4505 94.0007 69.4138 446.086 347.924 492.377 GO:0008080 N-acetyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.1521 21.4199 16.3102 13.8887 15.5413 13.1466 GO:0008080 N-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.484647 0 0.0994144 0 0 0 GO:0008080 N-acetyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.292475 1.06915 0.466806 0.760503 0.384402 0.401132 GO:0008081 phosphoric diester hydrolase activity molecular_function Escherichia Escherichia coli 0.0576492 0 0 0 0 0 GO:0008094 DNA-dependent ATPase activity molecular_function Clostridium Clostridium thermocellum 16.5444 106.025 77.9981 221.871 221.813 226.413 GO:0008094 DNA-dependent ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 75.3055 93.129 134.803 48.402 58.49 53.6726 GO:0008094 DNA-dependent ATPase activity molecular_function Escherichia Escherichia coli 0.139748 0 0 0 0 0.0384186 GO:0008094 DNA-dependent ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.649574 0.880404 2.35212 1.47032 0.193286 0.658258 GO:0008097 5S rRNA binding molecular_function Clostridium Clostridium thermocellum 1.0118 1.38261 0 6.06257 3.34383 4.79799 GO:0008097 5S rRNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 47.7832 66.6101 38.517 77.8544 102.211 85.4707 GO:0008097 5S rRNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.169837 1.30406 0.735775 0.753366 0.505895 0.975341 GO:0008106 alcohol dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0.105261 0 0 0 0 0.0743148 GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.59595 13.7924 5.45755 15.3531 18.278 12.0259 GO:0008113 peptide-methionine (S)-S-oxide reductase activity molecular_function Clostridium Clostridium thermocellum 0.217497 2.60971 0.706365 3.28263 1.65025 7.94968 GO:0008113 peptide-methionine (S)-S-oxide reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.85163 2.10927 1.80651 1.83144 1.68072 1.29517 GO:0008113 peptide-methionine (S)-S-oxide reductase activity molecular_function Escherichia Escherichia coli 0.0994036 0 0 0 0 0 GO:0008113 peptide-methionine (S)-S-oxide reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.403958 0.259319 0.250611 0 0 0 GO:0008115 sarcosine oxidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 24.9721 21.0834 19.3698 18.0473 21.2332 16.4641 GO:0008121 ubiquinol-cytochrome-c reductase activity molecular_function Clostridium Clostridium thermocellum 0.170857 0.787664 0.539201 1.69599 1.54104 2.41028 GO:0008131 primary amine oxidase activity molecular_function Escherichia Escherichia coli 0.0686346 0 0 0 0 0 GO:0008134 transcription factor binding molecular_function Escherichia Escherichia coli 0.0430911 0 0 0 0 0 GO:0008137 NADH dehydrogenase (ubiquinone) activity molecular_function Clostridium Clostridium thermocellum 14.3932 138.42 72.764 533.184 488.292 520.938 GO:0008137 NADH dehydrogenase (ubiquinone) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 114.261 138.653 121.844 161.211 169.648 101.808 GO:0008137 NADH dehydrogenase (ubiquinone) activity molecular_function Escherichia Escherichia coli 0.514347 0 0.0653591 0 0 0.106557 GO:0008137 NADH dehydrogenase (ubiquinone) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123853 0.409561 0.12941 1.09162 0.659269 0.401132 GO:0008138 protein tyrosine/serine/threonine phosphatase activity molecular_function Escherichia Escherichia coli 0.0208286 0 0.177945 0 0 0 GO:0008143 poly(A) binding molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.027294 GO:0008143 poly(A) binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.759696 2.22096 1.62162 1.49129 0.460601 0.920041 GO:0008152 metabolic process biological_process Clostridium Clostridium thermocellum 11.168 16.4009 29.6268 72.423 52.9498 59.8253 GO:0008152 metabolic process biological_process Escherichia Escherichia coli 0.0251547 0 0 0 0 0 GO:0008152 metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.511989 1.15709 0.932213 0.64635 0.758039 1.31066 GO:0008168 methyltransferase activity molecular_function Clostridium Clostridium thermocellum 24.4054 333.039 291.441 657.494 589.854 592.538 GO:0008168 methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 210.994 200.193 203.621 142.107 171.568 148.81 GO:0008168 methyltransferase activity molecular_function Escherichia Escherichia coli 0.296266 0 0.33523 0 0 0.256674 GO:0008168 methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.46826 3.50001 2.88031 2.92843 2.29107 2.82325 GO:0008170 N-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.114326 8.09129 5.53351 1.43152 1.85276 1.02906 GO:0008170 N-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.46258 3.89958 3.45221 6.18637 6.63148 3.68699 GO:0008170 N-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0768494 0 0.071268 0 0 0 GO:0008170 N-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0571388 0.192062 0 0.146112 0.102004 0.132978 GO:0008171 O-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.298211 2.00458 0.36897 5.43305 5.09589 4.95522 GO:0008173 RNA methyltransferase activity molecular_function Clostridium Clostridium thermocellum 16.5154 41.3666 32.725 101.785 92.4117 109.412 GO:0008173 RNA methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 62.1147 20.9657 24.0939 28.4997 33.7371 24.2185 GO:0008173 RNA methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0848211 0.0813054 0.0787106 0.303739 0 0 GO:0008175 tRNA methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.704259 6.47027 5.88268 16.0671 16.4713 25.6325 GO:0008175 tRNA methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.103709 0.400725 0.331593 0 0 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.19758 22.9953 17.6967 38.2731 45.5668 49.7891 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.27006 5.18488 3.72714 2.75951 2.54302 1.27764 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0426293 0 0 0 0 0 GO:0008177 succinate dehydrogenase (ubiquinone) activity molecular_function Escherichia Escherichia coli 0.0830956 0 0 0 0 0 GO:0008184 glycogen phosphorylase activity molecular_function Clostridium Clostridium thermocellum 2.1006 8.77968 7.46055 66.069 52.7995 53.1133 GO:0008184 glycogen phosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.0012 10.3973 8.3927600000000009 14.0098 14.1239 9.89496 GO:0008184 glycogen phosphorylase activity molecular_function Escherichia Escherichia coli 0.148984 0 0.0803795 0 0 0.0281348 GO:0008186 RNA-dependent ATPase activity molecular_function Clostridium Clostridium thermocellum 10.1748 24.4047 29.7108 58.603 55.1107 60.7126 GO:0008186 RNA-dependent ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 48.4172 47.7495 49.7599 47.5107 53.7822 25.0062 GO:0008186 RNA-dependent ATPase activity molecular_function Escherichia Escherichia coli 0.0437959 0 0.0812816 0 0 0.027294 GO:0008198 ferrous iron binding molecular_function Clostridium Clostridium thermocellum 3.19713 20.6728 23.0402 38.1483 43.2343 41.2012 GO:0008198 ferrous iron binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 62.4891 45.4467 49.2424 37.3337 55.9564 46.8678 GO:0008198 ferrous iron binding molecular_function Escherichia Escherichia coli 0.159435 0 0 0 0 0 GO:0008198 ferrous iron binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.403204 0.861642 1.07642 0.503371 0.0707732 0.174792 GO:0008199 ferric iron binding molecular_function Clostridium Clostridium thermocellum 6.25628 115.39 79.7483 294.479 169.316 373.564 GO:0008199 ferric iron binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 236.703 159.995 199.796 179.002 193.502 146.835 GO:0008199 ferric iron binding molecular_function Escherichia Escherichia coli 0.350464 0 0.660312 0 0 0.197785 GO:0008199 ferric iron binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.25642 0.1768 0.246461 0.297869 0.0822106 0.726687 GO:0008216 spermidine metabolic process biological_process Escherichia Escherichia coli 0.0852829 0 0 0 0 0 GO:0008233 peptidase activity molecular_function Clostridium Clostridium thermocellum 33.4122 124.989 104.637 327.936 309.368 384.097 GO:0008233 peptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 246.804 144.137 193.867 103.974 137.478 113.159 GO:0008233 peptidase activity molecular_function Escherichia Escherichia coli 0.281562 0 0.387373 0 0 0.0229283 GO:0008233 peptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.64777 3.59765 4.19178 3.63892 2.71909 3.41373 GO:0008234 cysteine-type peptidase activity molecular_function Clostridium Clostridium thermocellum 7.07246 25.0548 21.4841 39.2775 35.7906 61.1063 GO:0008234 cysteine-type peptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 41.2371 71.3365 60.2322 79.0146 88.6953 67.4213 GO:0008234 cysteine-type peptidase activity molecular_function Escherichia Escherichia coli 0.407871 0 0.207625 0 0 0 GO:0008235 metalloexopeptidase activity molecular_function Clostridium Clostridium thermocellum 0.309172 1.84039 0.688639 4.5854799999999996 4.02984 5.22299 GO:0008235 metalloexopeptidase activity molecular_function Escherichia Escherichia coli 0.0461291 0 0.0378893 0 0 0 GO:0008236 serine-type peptidase activity molecular_function Clostridium Clostridium thermocellum 12.2412 71.1457 51.4994 188.429 169.436 184.402 GO:0008236 serine-type peptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 196.107 125.357 126.794 93.0754 104.644 89.5583 GO:0008236 serine-type peptidase activity molecular_function Escherichia Escherichia coli 0.0511843 0 0 0 0 0.0379012 GO:0008236 serine-type peptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.206293 0.395139 0.861892 0.475119 0.368624 0.137311 GO:0008237 metallopeptidase activity molecular_function Clostridium Clostridium thermocellum 6.52338 33.9952 27.8926 100.731 88.4149 81.925 GO:0008237 metallopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 189.094 153.94 216.378 178.381 199.241 115.163 GO:0008237 metallopeptidase activity molecular_function Escherichia Escherichia coli 0.727834 0 0.841324 0 0 0.199531 GO:0008237 metallopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.6775 0.504355 0.942091 0.720885 0.324046 0.924407 GO:0008239 dipeptidyl-peptidase activity molecular_function Clostridium Clostridium thermocellum 0.309172 1.84039 0.688639 4.5854799999999996 4.02984 5.22299 GO:0008251 tRNA-specific adenosine deaminase activity molecular_function Escherichia Escherichia coli 0.068659 0 0 0 0 0 GO:0008252 nucleotidase activity molecular_function Escherichia Escherichia coli 0 0 0.116555 0 0 0.0883498 GO:0008253 5'-nucleotidase activity molecular_function Clostridium Clostridium thermocellum 0.467391 8.36461 6.45373 16.038 10.6595 18.6532 GO:0008253 5'-nucleotidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 312.975 70.6242 119.511 53.59 62.7981 51.8206 GO:0008253 5'-nucleotidase activity molecular_function Escherichia Escherichia coli 0.177371 0 0 0 0 0 GO:0008253 5'-nucleotidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.141183 0 0.13586 0 GO:0008254 3'-nucleotidase activity molecular_function Escherichia Escherichia coli 0 0 0.161661 0 0 0 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity molecular_function Escherichia Escherichia coli 0.272497 0 0 0 0 0 GO:0008270 zinc ion binding molecular_function Clostridium Clostridium thermocellum 121.632 845.19 691.368 2038.04 1960.51 2121.12 GO:0008270 zinc ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 531.423 413.505 476.427 326.229 408.752 358.994 GO:0008270 zinc ion binding molecular_function Escherichia Escherichia coli 4.09348 0 1.76447 0 0 1.82818 GO:0008270 zinc ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 11.9165 47.7652 52.1486 63.5636 19.6411 44.476 GO:0008271 secondary active sulfate transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 0.738989 113.725 100.607 227.825 204.608 207.385 GO:0008271 secondary active sulfate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.293933 0 0.904563 0 0 0 GO:0008273 calcium, potassium:sodium antiporter activity molecular_function Escherichia Escherichia coli 0.0880536 0 0 0 0 0 GO:0008276 protein methyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.12718 33.8063 26.6336 52.0638 60.7265 63.5674 GO:0008276 protein methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 18.5106 5.65722 5.81867 5.00208 6.73144 3.92394 GO:0008276 protein methyltransferase activity molecular_function Escherichia Escherichia coli 0.0663987 0 0.123231 0 0 0 GO:0008276 protein methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.4531 1.89542 0.896399 0.760503 0.416696 0.818271 GO:0008289 lipid binding molecular_function Clostridium Clostridium thermocellum 40.434 668.937 426.393 906.92 869.677 781.444 GO:0008289 lipid binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 30.5067 19.9254 17.9561 26.1985 31.6671 27.2967 GO:0008289 lipid binding molecular_function Escherichia Escherichia coli 0.0827067 0 0.535728 0 0 0.0247716 GO:0008295 spermidine biosynthetic process biological_process Clostridium Clostridium thermocellum 22.3671 181.953 124.444 740.079 737.444 1042.03 GO:0008295 spermidine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 91.4887 110.189 143.464 72.4909 93.239 81.7297 GO:0008295 spermidine biosynthetic process biological_process Escherichia Escherichia coli 0.167066 0 0.267075 0 0 0.095238 GO:0008296 3'-5'-exodeoxyribonuclease activity molecular_function Escherichia Escherichia coli 0.00811755 0 0.0450612 0 0 0 GO:0008299 isoprenoid biosynthetic process biological_process Clostridium Clostridium thermocellum 2.97119 17.9604 12.1521 59.794 56.8354 54.8149 GO:0008299 isoprenoid biosynthetic process biological_process Escherichia Escherichia coli 0.215067 0 0 0 0 0.077581 GO:0008299 isoprenoid biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.235579 0.688436 0 0.872668 0.602039 0.417689 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity molecular_function Escherichia Escherichia coli 0 0 0.0705914 0 0 0 GO:0008312 7S RNA binding molecular_function Clostridium Clostridium thermocellum 1.75473 21.6171 14.4992 36.0885 39.4842 42.3414 GO:0008312 7S RNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.3594 11.5885 11.5127 5.29587 7.73811 5.73753 GO:0008312 7S RNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.08797 0.475044 0.533924 0.674801 0.769651 0.246778 GO:0008320 protein transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.621406 0 0 0 0 0 GO:0008324 cation transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 2.51355 11.0644 11.4866 62.5828 36.163 32.0477 GO:0008324 cation transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 191.391 89.6278 118.539 97.2818 101.387 65.8208 GO:0008324 cation transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.360235 0 0.176185 0 0 0.0675236 GO:0008324 cation transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.902944 1.72487 1.54724 2.82278 1.64912 2.01235 GO:0008360 regulation of cell shape biological_process Clostridium Clostridium thermocellum 66.5047 419.356 357.738 1009.31 942.865 1047.15 GO:0008360 regulation of cell shape biological_process Coprothermobacter Coprothermobacter proteolyticus 296.192 270.097 213.356 254.444 272.511 206.652 GO:0008360 regulation of cell shape biological_process Escherichia Escherichia coli 1.72031 0 0.985844 0 0 0.506007 GO:0008375 acetylglucosaminyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.0383855 0 0 0 GO:0008381 mechanically-gated ion channel activity molecular_function Escherichia Escherichia coli 0.132797 0 0 0 0 0 GO:0008408 3'-5' exonuclease activity molecular_function Clostridium Clostridium thermocellum 9.81626 53.0587 43.1783 144.084 132.052 151.627 GO:0008408 3'-5' exonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 136.446 79.7879 109.482 47.9617 57.4811 46.6896 GO:0008408 3'-5' exonuclease activity molecular_function Escherichia Escherichia coli 0.434289 0 0.223006 0 0 0.0194033 GO:0008408 3'-5' exonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.315248 0.770955 0.677046 0.442539 0.114136 0.433632 GO:0008409 5'-3' exonuclease activity molecular_function Clostridium Clostridium thermocellum 3.33376 18.9304 15.4808 44.8822 39.9729 46.566 GO:0008409 5'-3' exonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.232128 0 0.32251 0.475343 0.103718 0.0772576 GO:0008410 CoA-transferase activity molecular_function Escherichia Escherichia coli 0.0227486 0 0 0 0 0 GO:0008412 4-hydroxybenzoate octaprenyltransferase activity molecular_function Escherichia Escherichia coli 0.100838 0 0.0623821 0 0 0 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity molecular_function Clostridium Clostridium thermocellum 0.296388 0.189728 1.64873 2.62815 3.08639 2.23481 GO:0008417 fucosyltransferase activity molecular_function Escherichia Escherichia coli 0.13061 0 0 0 0 0.069561 GO:0008422 beta-glucosidase activity molecular_function Clostridium Clostridium thermocellum 44.539 159.011 199.836 380.011 390.901 329.343 GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.106654 GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity molecular_function Clostridium Clostridium thermocellum 4.64815 30.4238 25.0534 76.7492 71.5545 67.4362 GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity molecular_function Escherichia Escherichia coli 0.060906 0 0 0 0 0 GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity molecular_function Clostridium Clostridium thermocellum 1.20035 4.47483 3.62673 11.2753 13.3918 13.4697 GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 92.503 36.1405 61.5543 21.013 24.3019 21.5417 GO:0008452 RNA ligase activity molecular_function Clostridium Clostridium thermocellum 0.910041 7.48463 3.94117 18.5528 19.1552 20.1523 GO:0008452 RNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 28.137 19.8382 24.1651 17.1563 18.6719 10.7006 GO:0008452 RNA ligase activity molecular_function Escherichia Escherichia coli 0.090241 0 0.33505 0 0 0 GO:0008452 RNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.184541 0.389771 0.136988 0.264345 0.23068 0.392303 GO:0008453 alanine-glyoxylate transaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 20.0107 25.3463 31.8029 33.1498 38.9397 22.471 GO:0008460 dTDP-glucose 4,6-dehydratase activity molecular_function Clostridium Clostridium thermocellum 0 0 0 0.118854 0.285068 0.0772576 GO:0008460 dTDP-glucose 4,6-dehydratase activity molecular_function Escherichia Escherichia coli 0.0794256 0 0.0963923 0 0 0.0691405 GO:0008460 dTDP-glucose 4,6-dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0845295 0 0.209564 0.0577733 0.20162 0.0749939 GO:0008470 isovaleryl-CoA dehydrogenase activity molecular_function Escherichia Escherichia coli 0.065864 0 0.0611642 0 0 0 GO:0008474 palmitoyl-(protein) hydrolase activity molecular_function Escherichia Escherichia coli 0.17567 0 0 0 0 0 GO:0008478 pyridoxal kinase activity molecular_function Escherichia Escherichia coli 0.0681243 0 0 0 0 0 GO:0008479 queuine tRNA-ribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.897136 7.70357 5.64186 27.2274 27.742 24.7672 GO:0008479 queuine tRNA-ribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.0316 1.57836 2.19519 2.15738 2.01841 1.60763 GO:0008479 queuine tRNA-ribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.247999 0.158737 0.153407 0.26335 0.0738116 0.12748 GO:0008483 transaminase activity molecular_function Clostridium Clostridium thermocellum 34.6064 1503.8 1284.56 797.63 836.735 918.54 GO:0008483 transaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 249.643 136.399 206.923 106.815 124.342 88.9495 GO:0008483 transaminase activity molecular_function Escherichia Escherichia coli 0.369106 0 0.207895 0 0 0 GO:0008483 transaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.517312 0.776229 0.879484 1.80773 1.4873 2.24962 GO:0008484 sulfuric ester hydrolase activity molecular_function Clostridium Clostridium thermocellum 1.70218 21.2246 14.8931 44.8457 44.6346 62.6851 GO:0008484 sulfuric ester hydrolase activity molecular_function Escherichia Escherichia coli 0.736097 0 0.334238 0 0 0.0433018 GO:0008495 protoheme IX farnesyltransferase activity molecular_function Escherichia Escherichia coli 0.0657425 0 0.122238 0 0 0 GO:0008519 ammonium transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.11158 0.342864 0.248536 0.228308 0.199298 0.239211 GO:0008531 riboflavin kinase activity molecular_function Clostridium Clostridium thermocellum 2.18476 13.2453 14.3414 40.3507 33.9304 35.5191 GO:0008531 riboflavin kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.502 12.0994 6.78476 11.8856 12.0771 13.8432 GO:0008531 riboflavin kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.204106 0.338159 0 0.295319 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity molecular_function Clostridium Clostridium thermocellum 0.658737 8.53306 5.56125 17.9834 10.9944 24.9227 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity molecular_function Escherichia Escherichia coli 0.110365 0 0 0 0 0 GO:0008551 cadmium-exporting ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.8413 1.36716 1.77033 2.1443 2.67512 1.34029 GO:0008551 cadmium-exporting ATPase activity molecular_function Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0008556 potassium-transporting ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.835325 0 0 0.0340529 GO:0008559 xenobiotic-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.090168 0 0 0 0 0.0396151 GO:0008565 protein transporter activity molecular_function Clostridium Clostridium thermocellum 2.81725 12.3044 8.49569 126.483 156.54 148.163 GO:0008565 protein transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 12.0461 16.6253 20.4181 8.68141 8.19072 6.27339 GO:0008565 protein transporter activity molecular_function Escherichia Escherichia coli 0.39132 0 0.265406 0 0 0.0639663 GO:0008565 protein transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.408308 0.58146 0.431532 1.25395 0.553511 0.26201 GO:0008609 alkylglycerone-phosphate synthase activity molecular_function Escherichia Escherichia coli 0.0372581 0 0 0 0 0.0495755 GO:0008610 lipid biosynthetic process biological_process Escherichia Escherichia coli 0.0372581 0 0.150204 0 0 0.0495755 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.125603 0 0 0.28919 0 0.0417172 GO:0008615 pyridoxine biosynthetic process biological_process Clostridium Clostridium thermocellum 4.64329 43.1918 35.0846 91.5843 88.7933 75.3085 GO:0008615 pyridoxine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 4.07375 7.12706 5.74208 2.3601 3.26514 4.11351 GO:0008615 pyridoxine biosynthetic process biological_process Escherichia Escherichia coli 0.055875 0 0.0959863 0 0 0.0555582 GO:0008616 queuosine biosynthetic process biological_process Clostridium Clostridium thermocellum 7.43787 63.0593 46.9281 191.288 179.866 167.202 GO:0008616 queuosine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 4.62479 5.68111 3.72944 3.46988 3.9781 3.72444 GO:0008616 queuosine biosynthetic process biological_process Escherichia Escherichia coli 0.3204 0 0.311279 0 0 0.12389 GO:0008616 queuosine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.247999 0.158737 0.153407 0.26335 0.0738116 0.12748 GO:0008641 small protein activating enzyme activity molecular_function Clostridium Clostridium thermocellum 1.55531 48.6527 40.5622 116.804 106.304 101.53 GO:0008641 small protein activating enzyme activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 42.592 60.7525 50.0251 65.998 73.718 62.6854 GO:0008641 small protein activating enzyme activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.240634 0.231034 0.669649 0.246239 0 0 GO:0008643 carbohydrate transport biological_process Clostridium Clostridium thermocellum 59.5931 306.415 198.873 1042.01 736.089 800.478 GO:0008643 carbohydrate transport biological_process Coprothermobacter Coprothermobacter proteolyticus 247.088 84.209 155.228 50.5251 51.841 56.4278 GO:0008643 carbohydrate transport biological_process Escherichia Escherichia coli 1.56265 0 0.920305 0 0 0.784186 GO:0008649 rRNA methyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.07106 19.5737 15.6598 64.815 59.9783 50.433 GO:0008649 rRNA methyltransferase activity molecular_function Escherichia Escherichia coli 0.0375012 0 0 0 0 0 GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.375871 0 0 0 GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.099914 0 0.185252 0.307047 0 0.0665534 GO:0008652 cellular amino acid biosynthetic process biological_process Clostridium Clostridium thermocellum 2.1678 11.7328 6.25914 43.8577 36.175 34.6783 GO:0008652 cellular amino acid biosynthetic process biological_process Escherichia Escherichia coli 0.0209987 0 0 0 0 0 GO:0008653 lipopolysaccharide metabolic process biological_process Escherichia Escherichia coli 0.304749 0 0 0 0 0 GO:0008654 phospholipid biosynthetic process biological_process Clostridium Clostridium thermocellum 23.5476 153.037 92.8648 476.971 429.473 359.52 GO:0008654 phospholipid biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 355.944 176.926 137.19 170.544 199.138 168.935 GO:0008654 phospholipid biosynthetic process biological_process Escherichia Escherichia coli 0.368887 0 0.399642 0 0 0 GO:0008654 phospholipid biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.29671 4.30961 4.19859 5.05565 3.42999 6.04643 GO:0008657 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity molecular_function Escherichia Escherichia coli 0.150029 0 0 0 0 0.673716 GO:0008658 penicillin binding molecular_function Clostridium Clostridium thermocellum 5.79754 27.9027 26.0004 75.947 69.6038 70.5358 GO:0008658 penicillin binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 18.5565 11.6189 6.88066 7.818 8.36936 10.2223 GO:0008658 penicillin binding molecular_function Escherichia Escherichia coli 0.164563 0 0.121562 0 0 0 GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity molecular_function Clostridium Clostridium thermocellum 11.4118 55.3911 37.2861 156.799 140.842 119.082 GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 58.509 41.4332 32.2915 34.7667 42.3967 30.6407 GO:0008662 1-phosphofructokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 58.606 34.7227 47.5948 14.0036 17.6034 15.7465 GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.36858 2.4759 1.09947 1.97859 2.67567 2.66498 GO:0008663 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity molecular_function Escherichia Escherichia coli 0 0 0.161661 0 0 0 GO:0008664 2'-5'-RNA ligase activity molecular_function Clostridium Clostridium thermocellum 2.05304 14.8595 15.0335 28.6236 25.8995 31.0351 GO:0008664 2'-5'-RNA ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.57913 6.22052 4.92814 6.42321 4.33271 8.69916 GO:0008664 2'-5'-RNA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.718792 0.460995 0.222735 0.429706 0 0 GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0814186 0 0 0 0 0 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity molecular_function Escherichia Escherichia coli 0.039008 0 0.144836 0 0 0 GO:0008671 2-dehydro-3-deoxygalactonokinase activity molecular_function Escherichia Escherichia coli 0.112528 0 0 0 0 0 GO:0008672 2-dehydro-3-deoxyglucarate aldolase activity molecular_function Escherichia Escherichia coli 0.0695339 0 0 0 0 0 GO:0008673 2-dehydro-3-deoxygluconokinase activity molecular_function Escherichia Escherichia coli 0.0623156 0 0.567393 0 0 0 GO:0008674 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity molecular_function Escherichia Escherichia coli 0.103876 0 0 0 0 0 GO:0008675 2-dehydro-3-deoxy-phosphogluconate aldolase activity molecular_function Escherichia Escherichia coli 0 0 0.183357 0 0 0 GO:0008676 3-deoxy-8-phosphooctulonate synthase activity molecular_function Escherichia Escherichia coli 0 0 0.0639608 0 0 0 GO:0008677 2-dehydropantoate 2-reductase activity molecular_function Escherichia Escherichia coli 0.103171 0 0 0 0 0 GO:0008678 2-deoxy-D-gluconate 3-dehydrogenase activity molecular_function Escherichia Escherichia coli 1.43953 0 0 0 0 0 GO:0008679 2-hydroxy-3-oxopropionate reductase activity molecular_function Escherichia Escherichia coli 0.0661313 0 0 0 0 0 GO:0008684 2-oxopent-4-enoate hydratase activity molecular_function Escherichia Escherichia coli 0 0 0.205008 0 0 0 GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.76 21.9113 19.3042 21.3913 29.527 21.6888 GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity molecular_function Clostridium Clostridium thermocellum 2.5136 14.1421 9.7049 36.0382 30.5943 26.5774 GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0900222 0.51845 0.668251 0.41451 0.321312 0.479101 GO:0008691 3-hydroxybutyryl-CoA dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0760717 0 0 0 0 0 GO:0008692 3-hydroxybutyryl-CoA epimerase activity molecular_function Escherichia Escherichia coli 0.0966572 0 0 0 0 0.0158461 GO:0008694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity molecular_function Escherichia Escherichia coli 0.0361644 0 0 0 0 0.0481203 GO:0008695 3-phenylpropionate dioxygenase activity molecular_function Escherichia Escherichia coli 0.172632 0 0.0765455 0 0 0 GO:0008697 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity molecular_function Escherichia Escherichia coli 0 0 0.0656748 0 0 0 GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity molecular_function Escherichia Escherichia coli 0 0 0.183357 0 0 0 GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity molecular_function Escherichia Escherichia coli 0.0509413 0 0 0 0 0 GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 37.2074 46.3509 67.3938 29.4897 30.3195 28.1634 GO:0008705 methionine synthase activity molecular_function Clostridium Clostridium thermocellum 1.02847 9.14238 5.55692 33.1248 26.5505 35.1121 GO:0008705 methionine synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.221945 0 0 0 0.24776 0 GO:0008705 methionine synthase activity molecular_function Escherichia Escherichia coli 0.0137561 0 0.0127651 0 0 0.0549114 GO:0008706 6-phospho-beta-glucosidase activity molecular_function Escherichia Escherichia coli 0.239638 0 0 0 0 0 GO:0008709 cholate 7-alpha-dehydrogenase activity molecular_function Escherichia Escherichia coli 0.157247 0 0 0 0 0 GO:0008710 8-amino-7-oxononanoate synthase activity molecular_function Clostridium Clostridium thermocellum 0 1.28413 0.221743 0.73342 1.19331 1.39811 GO:0008710 8-amino-7-oxononanoate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 134.433 98.7123 165.423 101.135 109.359 59.248 GO:0008712 ADP-glyceromanno-heptose 6-epimerase activity molecular_function Escherichia Escherichia coli 0.124194 0 0 0 0 0 GO:0008713 ADP-heptose-lipopolysaccharide heptosyltransferase activity molecular_function Escherichia Escherichia coli 0.319452 0 0.0976553 0 0 0.0721157 GO:0008716 D-alanine-D-alanine ligase activity molecular_function Clostridium Clostridium thermocellum 5.92112 26.9703 36.235 49.0845 53.315 63.7877 GO:0008716 D-alanine-D-alanine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.6178 7.50381 4.59841 9.97003 7.99564 9.1715 GO:0008716 D-alanine-D-alanine ligase activity molecular_function Escherichia Escherichia coli 0.165875 0 0.153948 0 0 0 GO:0008720 D-lactate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0311578 0 0 0 0 0 GO:0008721 D-serine ammonia-lyase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.8998 8.65483 7.6177 10.4077 13.1879 9.88361 GO:0008725 DNA-3-methyladenine glycosylase activity molecular_function Escherichia Escherichia coli 0.234826 0 0.324811 0 0 0 GO:0008728 GTP diphosphokinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.1728 7.58619 5.60298 8.45164 9.38304 7.76994 GO:0008728 GTP diphosphokinase activity molecular_function Escherichia Escherichia coli 0.0785264 0 0 0 0 0 GO:0008730 L(+)-tartrate dehydratase activity molecular_function Escherichia Escherichia coli 0.0637981 0 0 0 0 0.0848249 GO:0008730 L(+)-tartrate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.0714767 0.186906 0.092942 GO:0008734 L-aspartate oxidase activity molecular_function Clostridium Clostridium thermocellum 2.029 11.9143 6.784 25.377 25.8602 20.0365 GO:0008734 L-aspartate oxidase activity molecular_function Escherichia Escherichia coli 0.0330049 0 0 0 0 0 GO:0008736 L-fucose isomerase activity molecular_function Escherichia Escherichia coli 0.014947 0 0.0554808 0 0 0 GO:0008740 L-rhamnose isomerase activity molecular_function Escherichia Escherichia coli 0.0437716 0 0 0 0 0 GO:0008742 L-ribulose-phosphate 4-epimerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.26478 1.75824 3.5795 2.61482 2.92358 3.20734 GO:0008743 L-threonine 3-dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 1.04194 14.1858 11.3134 21.2411 23.4366 38.7121 GO:0008743 L-threonine 3-dehydrogenase activity molecular_function Escherichia Escherichia coli 0.377831 0 0.0900323 0 0 0 GO:0008744 L-xylulokinase activity molecular_function Escherichia Escherichia coli 0.0359457 0 0.267842 0 0 0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular_function Clostridium Clostridium thermocellum 7.10339 23.5058 19.0309 126.018 116.203 118.523 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.0948 12.6157 10.4638 7.60829 8.64425 9.36065 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular_function Escherichia Escherichia coli 0.0675167 0 0 0 0 0.21583 GO:0008747 N-acetylneuraminate lyase activity molecular_function Escherichia Escherichia coli 0.130659 0 0 0 0 0.0434635 GO:0008748 N-ethylmaleimide reductase activity molecular_function Escherichia Escherichia coli 0.165389 0 0 0 0 0 GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity molecular_function Escherichia Escherichia coli 0.0392267 0 0 0 0 0.0260975 GO:0008752 FMN reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0532988 0.511776 0 0.10908 0.285567 0.0709192 GO:0008756 o-succinylbenzoate-CoA ligase activity molecular_function Escherichia Escherichia coli 0 0 0.114796 0 0 0 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.90585 10.6931 9.83756 42.5034 41.2786 45.8459 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity molecular_function Escherichia Escherichia coli 0.178708 0 0 0 0 0.0680087 GO:0008760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity molecular_function Clostridium Clostridium thermocellum 15.7121 94.3411 68.7886 207.11 180.461 207.703 GO:0008760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.7477 23.8692 17.1089 21.6449 23.5611 21.4403 GO:0008760 UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity molecular_function Escherichia Escherichia coli 0.0600067 0 0.0812816 0 0 0 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity molecular_function Clostridium Clostridium thermocellum 2.92271 22.322 22.6089 55.7991 61.8888 59.941 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 38.8843 38.8641 37.9197 31.6798 32.5771 32.4612 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.16483 0 0.767079 0.359498 0.166049 0.219937 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 2.82282 15.6682 16.9749 45.2639 42.9255 46.6343 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.8142 45.5113 19.1255 25.9375 35.8126 29.5353 GO:0008762 UDP-N-acetylmuramate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0276094 0 0.205279 0 0 0.147174 GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity molecular_function Clostridium Clostridium thermocellum 0.443573 2.03716 1.14417 4.28102 4.49404 5.82362 GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.38647 5.06801 2.84211 7.00932 6.40468 4.66566 GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity molecular_function Escherichia Escherichia coli 0.0732767 0 0 0 0 0 GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity molecular_function Clostridium Clostridium thermocellum 1.67047 7.83337 6.48665 14.8667 16.8925 28.5573 GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 69.0901 51.0666 35.3913 44.1491 44.1554 39.7252 GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.110825 GO:0008765 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.8484 6.35919 3.91428 6.04182 7.49536 6.00591 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity molecular_function Clostridium Clostridium thermocellum 2.66061 18.9106 21.8839 51.6569 46.4233 52.6138 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 93.6144 85.4518 89.3883 66.6686 70.5838 51.1285 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity molecular_function Escherichia Escherichia coli 0.0401989 0 0 0 0 0 GO:0008767 UDP-galactopyranose mutase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.1574 28.828 18.8548 28.2784 39.0091 28.4669 GO:0008767 UDP-galactopyranose mutase activity molecular_function Escherichia Escherichia coli 0 0 0.189131 0 0 0 GO:0008767 UDP-galactopyranose mutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0489241 0 0 0.0250442 0.0437097 0.130196 GO:0008768 UDP-sugar diphosphatase activity molecular_function Escherichia Escherichia coli 0.0161622 0 0 0 0 0 GO:0008771 [citrate (pro-3S)-lyase] ligase activity molecular_function Escherichia Escherichia coli 0.080252 0 0.0994144 0 0 0 GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity molecular_function Escherichia Escherichia coli 0.0919179 0 0.056834 0 0 0.0409087 GO:0008773 [protein-PII] uridylyltransferase activity molecular_function Escherichia Escherichia coli 0.0576492 0 0 0 0 0 GO:0008774 acetaldehyde dehydrogenase (acetylating) activity molecular_function Clostridium Clostridium thermocellum 0.658664 16.1959 9.70495 72.5495 65.9282 34.2944 GO:0008774 acetaldehyde dehydrogenase (acetylating) activity molecular_function Escherichia Escherichia coli 0.0192731 0 0 0 0 0 GO:0008775 acetate CoA-transferase activity molecular_function Escherichia Escherichia coli 0.0336125 0 0.211098 0 0 0.24694 GO:0008776 acetate kinase activity molecular_function Clostridium Clostridium thermocellum 4.97497 31.7717 26.5377 74.1942 75.7388 54.5204 GO:0008776 acetate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.0488 43.0591 49.0291 50.1978 48.3386 32.4178 GO:0008776 acetate kinase activity molecular_function Escherichia Escherichia coli 0.0923068 0 0 0 0 0.0613792 GO:0008777 acetylornithine deacetylase activity molecular_function Escherichia Escherichia coli 0.0727663 0 0 0 0 0 GO:0008779 acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity molecular_function Escherichia Escherichia coli 0.0121034 0 0 0 0 0 GO:0008783 agmatinase activity molecular_function Clostridium Clostridium thermocellum 1.78679 13.4693 13.2085 36.5505 39.1243 37.5637 GO:0008783 agmatinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.13654 0.328209 0.126884 0.0699597 0.304774 0.454394 GO:0008784 alanine racemase activity molecular_function Clostridium Clostridium thermocellum 0.852732 8.32088 5.31565 23.5014 22.1396 20.8272 GO:0008784 alanine racemase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.03638 4.11012 2.81549 4.96229 3.96708 5.04632 GO:0008784 alanine racemase activity molecular_function Escherichia Escherichia coli 0.052278 0 0 0 0 0 GO:0008785 alkyl hydroperoxide reductase activity molecular_function Clostridium Clostridium thermocellum 16.7778 159.381 159.13 520.725 417.94 348.992 GO:0008785 alkyl hydroperoxide reductase activity molecular_function Escherichia Escherichia coli 0 0 0.0636902 0 0 0 GO:0008786 allose 6-phosphate isomerase activity molecular_function Escherichia Escherichia coli 0 0 0.300724 0 0 0 GO:0008787 allose kinase activity molecular_function Escherichia Escherichia coli 0 0 0.404198 0 0 0 GO:0008791 arginine N-succinyltransferase activity molecular_function Escherichia Escherichia coli 0.0549272 0 0 0 0 0 GO:0008792 arginine decarboxylase activity molecular_function Clostridium Clostridium thermocellum 2.07724 22.2313 19.2719 50.6028 48.4844 63.904 GO:0008792 arginine decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 29.0916 43.415 37.4389 30.963 30.8548 24.9635 GO:0008792 arginine decarboxylase activity molecular_function Escherichia Escherichia coli 0.0495317 0 0.0493915 0 0 0 GO:0008792 arginine decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.305059 0.147408 0 0 0 GO:0008793 aromatic-amino-acid:2-oxoglutarate aminotransferase activity molecular_function Escherichia Escherichia coli 0.0698499 0 0 0 0 0 GO:0008794 arsenate reductase (glutaredoxin) activity molecular_function Escherichia Escherichia coli 0.231472 0 0 0 0 0 GO:0008795 NAD+ synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.32506 8.8734 6.57136 6.87448 8.45912 10.685 GO:0008795 NAD+ synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0720129 0.276494 0.801901 0.294711 0.160819 0.670579 GO:0008798 beta-aspartyl-peptidase activity molecular_function Clostridium Clostridium thermocellum 0 0.136474 0.219803 1.1145 0.99395 1.70167 GO:0008798 beta-aspartyl-peptidase activity molecular_function Escherichia Escherichia coli 0.0596421 0 0.0552553 0 0 0 GO:0008800 beta-lactamase activity molecular_function Clostridium Clostridium thermocellum 133936 95932 83193.2 37667.8 49698.2 17083.2 GO:0008800 beta-lactamase activity molecular_function Escherichia Escherichia coli 77927.8 0 34222.8 0 0 7845.05 GO:0008801 beta-phosphoglucomutase activity molecular_function Escherichia Escherichia coli 0.0476602 0 0 0 0 0 GO:0008802 betaine-aldehyde dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0319598 0 0.162338 0 0 0 GO:0008803 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity molecular_function Escherichia Escherichia coli 0.0695339 0 0 0 0 0 GO:0008804 carbamate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 82.2044 17.393 23.6271 27.2268 30.7455 22.1183 GO:0008804 carbamate kinase activity molecular_function Escherichia Escherichia coli 0.0620482 0 0 0 0 0 GO:0008806 carboxymethylenebutenolidase activity molecular_function Escherichia Escherichia coli 0.0732524 0 0 0 0 0 GO:0008808 cardiolipin synthase activity molecular_function Clostridium Clostridium thermocellum 0.139359 3.14249 2.90972 4.88365 5.64617 5.83995 GO:0008808 cardiolipin synthase activity molecular_function Escherichia Escherichia coli 0.0368206 0 0.0826348 0 0 0.0296224 GO:0008810 cellulase activity molecular_function Clostridium Clostridium thermocellum 277.868 290.699 258.98 1025.09 852.867 885.348 GO:0008810 cellulase activity molecular_function Escherichia Escherichia coli 0.0761932 0 0 0 0 0 GO:0008812 choline dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0319598 0 0.088634 0 0 0 GO:0008814 citrate CoA-transferase activity molecular_function Escherichia Escherichia coli 0.0351437 0 0 0 0 0 GO:0008815 citrate (pro-3S)-lyase activity molecular_function Escherichia Escherichia coli 0.0351437 0 0 0 0 0 GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.65144 22.8684 15.9601 71.1048 63.2645 77.3703 GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 19.8117 26.9325 13.3741 32.1034 34.5025 26.5592 GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity molecular_function Escherichia Escherichia coli 0.330535 0 0 0 0 0 GO:0008818 cobalamin 5'-phosphate synthase activity molecular_function Clostridium Clostridium thermocellum 0.529245 6.25324 3.85109 14.4517 14.1 18.0306 GO:0008818 cobalamin 5'-phosphate synthase activity molecular_function Escherichia Escherichia coli 0 0 0.151602 0 0 0 GO:0008818 cobalamin 5'-phosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.225532 0.165809 0.0723358 0.215506 GO:0008821 crossover junction endodeoxyribonuclease activity molecular_function Clostridium Clostridium thermocellum 0.500809 2.89171 0.791977 5.86776 6.65663 10.6703 GO:0008821 crossover junction endodeoxyribonuclease activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 115.224 247.569 243.498 105.74 109.677 88.587 GO:0008821 crossover junction endodeoxyribonuclease activity molecular_function Escherichia Escherichia coli 0.0633364 0 0 0 0 0 GO:0008821 crossover junction endodeoxyribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0.0750921 0.247328 GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity molecular_function Escherichia Escherichia coli 0 0 0.0903029 0 0 0 GO:0008827 cytochrome o ubiquinol oxidase activity molecular_function Escherichia Escherichia coli 0.104532 0 0 0 0 0 GO:0008829 dCTP deaminase activity molecular_function Clostridium Clostridium thermocellum 2.44795 10.3579 10.2479 25.2983 25.9347 35.8891 GO:0008829 dCTP deaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.83 23.6456 13.4701 22.3517 31.1397 20.7496 GO:0008829 dCTP deaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.107302 0 0 0.219603 0.04792 0 GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity molecular_function Clostridium Clostridium thermocellum 2.41757 17.5311 19.2926 47.297 40.3979 54.0843 GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity molecular_function Escherichia Escherichia coli 0.118993 0 0 0 0 0 GO:0008830 dTDP-4-dehydrorhamnose 3,5-epimerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0595692 0 0.330043 0 0 0.312879 GO:0008831 dTDP-4-dehydrorhamnose reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0700929 0 0 0.14355 0.187904 0.139995 GO:0008832 dGTPase activity molecular_function Clostridium Clostridium thermocellum 1.23528 7.17098 4.74217 16.84 15.7692 21.3615 GO:0008832 dGTPase activity molecular_function Escherichia Escherichia coli 0.0861822 0 0.159947 0 0 0 GO:0008833 deoxyribonuclease IV (phage-T4-induced) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.4279 2.54521 2.80124 1.05492 2.42825 2.98876 GO:0008834 di-trans,poly-cis-decaprenylcistransferase activity molecular_function Escherichia Escherichia coli 0.0797416 0 0 0 0 0 GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity molecular_function Escherichia Escherichia coli 0.0509413 0 0 0 0 0 GO:0008836 diaminopimelate decarboxylase activity molecular_function Clostridium Clostridium thermocellum 0.417568 12.3454 10.6147 52.5189 52.3375 69.821 GO:0008836 diaminopimelate decarboxylase activity molecular_function Escherichia Escherichia coli 0.0436744 0 0.0810561 0 0 0 GO:0008836 diaminopimelate decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0641141 0.533619 0.476052 0.459326 0.152658 0.312749 GO:0008837 diaminopimelate epimerase activity molecular_function Clostridium Clostridium thermocellum 0.631128 23.7695 32.1361 39.4224 43.0437 78.4114 GO:0008837 diaminopimelate epimerase activity molecular_function Escherichia Escherichia coli 0 0 0.13365 0 0 0 GO:0008837 diaminopimelate epimerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.236284 0.324102 0.560717 0.897886 0.361419 0.314399 GO:0008838 diaminopropionate ammonia-lyase activity molecular_function Escherichia Escherichia coli 0 0 0.0918816 0 0 0 GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase molecular_function Clostridium Clostridium thermocellum 4.06544 9.76006 8.49578 22.5395 26.214 33.86 GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase molecular_function Escherichia Escherichia coli 0.103973 0 0.0439787 0 0 0 GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.642405 1.07298 1.22283 1.0671 0.516638 1.49693 GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase molecular_function Clostridium Clostridium thermocellum 1.79903 4.86288 6.05792 20.2576 20.471800000000002 16.4978 GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.6663 32.0953 53.8209 19.8541 22.3277 22.2371 GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.346211 0.332316 0.835099 0.602106 0.247326 0.690662 GO:0008847 Enterobacter ribonuclease activity molecular_function Escherichia Escherichia coli 0.0369908 0 0 0 0 0 GO:0008849 enterochelin esterase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0307219 GO:0008852 exodeoxyribonuclease I activity molecular_function Escherichia Escherichia coli 0 0 0.0705914 0 0 0 GO:0008853 exodeoxyribonuclease III activity molecular_function Clostridium Clostridium thermocellum 2.72687 31.9533 20.168 68.6812 56.3785 96.8593 GO:0008853 exodeoxyribonuclease III activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.194748 0.448673 1.29956 0.356762 0.347919 0.206807 GO:0008854 exodeoxyribonuclease V activity molecular_function Clostridium Clostridium thermocellum 1.90991 12.3852 7.99226 25.3602 28.2005 32.8534 GO:0008854 exodeoxyribonuclease V activity molecular_function Escherichia Escherichia coli 0.0591804 0 0 0 0 0 GO:0008855 exodeoxyribonuclease VII activity molecular_function Clostridium Clostridium thermocellum 9.96534 32.9928 26.8289 117.871 107.577 100.856 GO:0008859 exoribonuclease II activity molecular_function Clostridium Clostridium thermocellum 4.55329 15.0492 17.6433 32.604 34.212 38.5598 GO:0008859 exoribonuclease II activity molecular_function Escherichia Escherichia coli 0.0211931 0 0 0 0 0 GO:0008860 ferredoxin-NAD+ reductase activity molecular_function Clostridium Clostridium thermocellum 0.693711 18.2606 26.7851 56.2473 59.6931 111.807 GO:0008860 ferredoxin-NAD+ reductase activity molecular_function Escherichia Escherichia coli 0.0230889 0 0 0 0 0 GO:0008861 formate C-acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 6.52107 50.7032 43.4059 122.485 102.544 118.133 GO:0008861 formate C-acetyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 12.2128 10.0403 11.7339 5.33922 5.87136 5.90738 GO:0008861 formate C-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.0675653 0 0.0817327 0 0 0.206969 GO:0008863 formate dehydrogenase (NAD+) activity molecular_function Escherichia Escherichia coli 0.173677 0 0.122734 0 0 0.0263239 GO:0008863 formate dehydrogenase (NAD+) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.180019 0.0992815 0 0 GO:0008866 fructuronate reductase activity molecular_function Escherichia Escherichia coli 0.0554375 0 0 0 0 0 GO:0008867 galactarate dehydratase activity molecular_function Escherichia Escherichia coli 0.0335639 0 0 0 0 0 GO:0008868 galactitol-1-phosphate 5-dehydrogenase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.07577 GO:0008872 glucarate dehydratase activity molecular_function Escherichia Escherichia coli 0.0507469 0 0 0 0 0 GO:0008878 glucose-1-phosphate adenylyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.41814 12.5801 8.53354 55.3722 59.9012 52.6519 GO:0008878 glucose-1-phosphate adenylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 55.6787 29.383 28.2237 27.0182 27.6617 26.7756 GO:0008878 glucose-1-phosphate adenylyltransferase activity molecular_function Escherichia Escherichia coli 0.0636037 0 0.0787106 0 0 0 GO:0008879 glucose-1-phosphate thymidylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.26015 1.99964 4.92832 0.722029 1.58891 1.92271 GO:0008879 glucose-1-phosphate thymidylyltransferase activity molecular_function Escherichia Escherichia coli 0.231618 0 0.12314 0 0 0.0961435 GO:0008879 glucose-1-phosphate thymidylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0667146 0.0640362 0.185613 0.102117 0 0 GO:0008880 glucuronate isomerase activity molecular_function Escherichia Escherichia coli 0.057309 0 0.0705914 0 0 0 GO:0008881 glutamate racemase activity molecular_function Clostridium Clostridium thermocellum 5.7221 25.3437 28.2647 44.3002 51.8337 49.9638 GO:0008881 glutamate racemase activity molecular_function Escherichia Escherichia coli 0.0760717 0 0 0 0 0.101221 GO:0008883 glutamyl-tRNA reductase activity molecular_function Clostridium Clostridium thermocellum 0.0574548 5.29461 5.06386 11.608 7.87258 5.57901 GO:0008883 glutamyl-tRNA reductase activity molecular_function Escherichia Escherichia coli 0 0 0.162654 0 0 0 GO:0008883 glutamyl-tRNA reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.321275 1.10178 1.5743 0.867768 0.204941 0.518942 GO:0008884 glutathionylspermidine amidase activity molecular_function Escherichia Escherichia coli 0.0852829 0 0 0 0 0 GO:0008885 glutathionylspermidine synthase activity molecular_function Escherichia Escherichia coli 0.0852829 0 0 0 0 0 GO:0008887 glycerate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 42.8886 9.93042 11.9993 14.1016 15.5978 11.3916 GO:0008887 glycerate kinase activity molecular_function Escherichia Escherichia coli 0.0976051 0 0 0 0 0.129873 GO:0008888 glycerol dehydrogenase [NAD+] activity molecular_function Escherichia Escherichia coli 0.0508684 0 0 0 0 0 GO:0008889 glycerophosphodiester phosphodiesterase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 44.9157 25.4133 31.2513 18.283 20.8246 13.5499 GO:0008889 glycerophosphodiester phosphodiesterase activity molecular_function Escherichia Escherichia coli 0.0262241 0 0 0 0 0 GO:0008890 glycine C-acetyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 134.433 98.7123 165.423 101.135 109.359 59.248 GO:0008890 glycine C-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.0696311 0 0 0 0 0 GO:0008891 glycolate oxidase activity molecular_function Escherichia Escherichia coli 0.0359943 0 0.0668025 0 0 0 GO:0008894 guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity molecular_function Escherichia Escherichia coli 0.254877 0 0.0675693 0 0 0.0484437 GO:0008897 holo-[acyl-carrier-protein] synthase activity molecular_function Clostridium Clostridium thermocellum 3.1134 23.8982 26.3249 55.7143 50.028 67.7148 GO:0008897 holo-[acyl-carrier-protein] synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 7.96412 13.1862 9.17571 10.6701 11.5054 8.74583 GO:0008897 holo-[acyl-carrier-protein] synthase activity molecular_function Escherichia Escherichia coli 0.278913 0 0.0729821 0 0 0.147659 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0137561 0 0.0127651 0 0 0.0549114 GO:0008899 homoserine O-succinyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.80171 18.6499 14.2566 39.4573 34.2343 40.4424 GO:0008899 homoserine O-succinyltransferase activity molecular_function Escherichia Escherichia coli 0.155789 0 0.346913 0 0 0 GO:0008901 ferredoxin hydrogenase activity molecular_function Clostridium Clostridium thermocellum 7.39113 47.3819 28.6591 262.74 233.096 198.697 GO:0008901 ferredoxin hydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 72.8251 71.6263 56.2895 66.987 100.712 65.7144 GO:0008901 ferredoxin hydrogenase activity molecular_function Escherichia Escherichia coli 0.0312793 0 0.0465498 0 0 0 GO:0008901 ferredoxin hydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 8.38981 7.17588 26.2628 12.3054 11.6651 29.7389 GO:0008908 isochorismatase activity molecular_function Escherichia Escherichia coli 0 0 0.127425 0 0 0 GO:0008909 isochorismate synthase activity molecular_function Escherichia Escherichia coli 0.0236965 0 0 0 0 0 GO:0008911 lactaldehyde dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0389594 0 0 0 0 0 GO:0008911 lactaldehyde dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.0740646 0 0 0 GO:0008914 leucyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.704623 2.19613 0.980296 6.0269 4.87048 7.72586 GO:0008914 leucyltransferase activity molecular_function Escherichia Escherichia coli 0.0872759 0 0 0 0 0 GO:0008917 lipopolysaccharide N-acetylglucosaminyltransferase activity molecular_function Escherichia Escherichia coli 0.157831 0 0.0976553 0 0 0 GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity molecular_function Escherichia Escherichia coli 0.671715 0 0.259948 0 0 0.372512 GO:0008919 lipopolysaccharide glucosyltransferase I activity molecular_function Escherichia Escherichia coli 0.591877 0 0.208121 0 0 0.22385 GO:0008921 lipopolysaccharide-1,6-galactosyltransferase activity molecular_function Escherichia Escherichia coli 0.365509 0 0.407987 0 0 0.181033 GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity molecular_function Escherichia Escherichia coli 0.0121034 0 0 0 0 0 GO:0008923 lysine decarboxylase activity molecular_function Clostridium Clostridium thermocellum 0.815595 7.43865 3.57716 26.3429 23.4271 26.2391 GO:0008923 lysine decarboxylase activity molecular_function Escherichia Escherichia coli 0.0486567 0 0.0225983 0 0 0 GO:0008925 maltose O-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.120913 0 0 0 0 0 GO:0008926 mannitol-1-phosphate 5-dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0243284 0 0.225757 0 0 0 GO:0008929 methylglyoxal synthase activity molecular_function Clostridium Clostridium thermocellum 14.5058 68.6207 67.2482 226.88 198.339 202.822 GO:0008929 methylglyoxal synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.8476 8.17008 7.28098 5.97475 7.36417 4.43159 GO:0008932 lytic endotransglycosylase activity molecular_function Escherichia Escherichia coli 0.0509413 0 0 0 0 0 GO:0008933 lytic transglycosylase activity molecular_function Clostridium Clostridium thermocellum 3.37987 22.2586 12.6333 61.629 55.6229 67.9723 GO:0008933 lytic transglycosylase activity molecular_function Escherichia Escherichia coli 0.314033 0 0 0 0 0.0656156 GO:0008934 inositol monophosphate 1-phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 37.3761 42.5571 34.4422 32.5891 40.4493 39.8263 GO:0008934 inositol monophosphate 1-phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.27587 0 0 0 GO:0008934 inositol monophosphate 1-phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0701415 0.06735 0.260354 0.0717752 0.156587 0 GO:0008939 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.42921 3.60526 1.94088 5.81473 5.79509 6.63769 GO:0008939 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity molecular_function Escherichia Escherichia coli 0.052278 0 0.0484893 0 0 0 GO:0008939 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.13061 0.250917 0.0970238 0.080231 0.140114 0.312943 GO:0008940 nitrate reductase activity molecular_function Escherichia Escherichia coli 0.176593 0 0 0 0 0 GO:0008941 nitric oxide dioxygenase activity molecular_function Escherichia Escherichia coli 0.0466881 0 0 0 0 0 GO:0008942 nitrite reductase [NAD(P)H] activity molecular_function Escherichia Escherichia coli 0.0812241 0 0 0 0 0 GO:0008948 oxaloacetate decarboxylase activity molecular_function Clostridium Clostridium thermocellum 8.12293 37.4354 30.9941 110.292 106.89 100.995 GO:0008948 oxaloacetate decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 80.9923 54.3957 54.9056 41.5088 43.4297 35.3704 GO:0008948 oxaloacetate decarboxylase activity molecular_function Escherichia Escherichia coli 0.0541008 0 0 0 0 0 GO:0008948 oxaloacetate decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0312307 0.149776 0.115788 0.159741 0.0975763 0.228442 GO:0008949 oxalyl-CoA decarboxylase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0418465 GO:0008955 peptidoglycan glycosyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.22279 6.72394 4.65502 17.615 16.7616 17.2018 GO:0008955 peptidoglycan glycosyltransferase activity molecular_function Escherichia Escherichia coli 0.0705061 0 0.0375285 0 0 0 GO:0008959 phosphate acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.82636 26.167 24.122 49.8 56.3004 73.964 GO:0008959 phosphate acetyltransferase activity molecular_function Escherichia Escherichia coli 0.0227 0 0 0 0 0 GO:0008960 phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity molecular_function Escherichia Escherichia coli 0.0907756 0 0 0 0 0 GO:0008961 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity molecular_function Clostridium Clostridium thermocellum 1.97208 5.6224 2.38586 18.0107 13.9535 12.5643 GO:0008961 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 45.9846 64.7185 78.0134 26.6446 31.0394 36.6187 GO:0008961 phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity molecular_function Escherichia Escherichia coli 0.0669577 0 0 0 0 0 GO:0008962 phosphatidylglycerophosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.244476 0 0 0.175277 GO:0008962 phosphatidylglycerophosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.359773 0.138901 0.335591 0.147927 0.0322939 0 GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity molecular_function Clostridium Clostridium thermocellum 8.31155 50.4013 54.5091 143.257 142.31 148.974 GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 123.001 63.0804 56.0024 53.3677 45.8565 36.7708 GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity molecular_function Escherichia Escherichia coli 0.0765578 0 0.0472715 0 0 0 GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.16816 0.439805 0.10618 0.28924 0.0766981 0.257062 GO:0008964 phosphoenolpyruvate carboxylase activity molecular_function Escherichia Escherichia coli 0.0194432 0 0 0 0 0.025483 GO:0008964 phosphoenolpyruvate carboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0342444 0.262166 0 0.262877 0.15294 0.159528 GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.6681 14.503 13.2736 20.8846 25.1986 16.0168 GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity molecular_function Escherichia Escherichia coli 0.251839 0 0.0430315 0 0 0.0308513 GO:0008966 phosphoglucosamine mutase activity molecular_function Clostridium Clostridium thermocellum 5.04163 23.9885 14.9549 76.3643 62.9168 59.3693 GO:0008966 phosphoglucosamine mutase activity molecular_function Escherichia Escherichia coli 0.0409037 0 0 0 0 0.0543617 GO:0008966 phosphoglucosamine mutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.280226 0.384217 0.372578 0.553659 0.249866 0.132719 GO:0008967 phosphoglycolate phosphatase activity molecular_function Clostridium Clostridium thermocellum 0.916311 12.1999 8.4127 33.9792 34.1312 43.0966 GO:0008967 phosphoglycolate phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.188405 0.361814 0.262248 0.240991 0.0420603 0.125346 GO:0008972 phosphomethylpyrimidine kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0 0.146088 0 0 0 0 GO:0008972 phosphomethylpyrimidine kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.305059 0.147408 0.243752 0.0708166 0.105683 GO:0008973 phosphopentomutase activity molecular_function Clostridium Clostridium thermocellum 0.81263 4.4486 5.05268 10.4408 12.9069 10.716 GO:0008973 phosphopentomutase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.6687 10.4423 9.26466 12.7706 15.3251 11.6857 GO:0008973 phosphopentomutase activity molecular_function Escherichia Escherichia coli 0.180458 0 0 0 0 0.060215 GO:0008977 prephenate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 3.38371 16.3874 12.5114 61.2005 62.8299 58.0045 GO:0008977 prephenate dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.2427 0.544541 0.41349 0.496905 0.289343 0.565963 GO:0008979 prophage integrase activity molecular_function Escherichia Escherichia coli 0.0479276 0 0 0 0 0 GO:0008980 propionate kinase activity molecular_function Escherichia Escherichia coli 0.0457159 0 0 0 0 0 GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1256.29 552.953 731.412 428.284 475.558 378.832 GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity molecular_function Escherichia Escherichia coli 1.17274 0 2.2513 0 0 0.339235 GO:0008983 protein-glutamate O-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.35053 3.84595 4.45073 48.6816 37.6826 26.3392 GO:0008983 protein-glutamate O-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0395184 0.151783 0 0.0403642 0.0705779 0 GO:0008984 protein-glutamate methylesterase activity molecular_function Clostridium Clostridium thermocellum 3.25315 9.02579 9.47242 86.7788 82.4587 83.4675 GO:0008984 protein-glutamate methylesterase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.8894 20.1219 28.0721 10.4345 16.3788 14.0895 GO:0008986 pyruvate, water dikinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.607431 0.574832 0.355077 0.495985 0.352955 0.322516 GO:0008987 quinolinate synthetase A activity molecular_function Clostridium Clostridium thermocellum 3.74812 39.4446 33.242 88.3542 86.2584 79.0776 GO:0008987 quinolinate synthetase A activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0953205 0.122005 0 0.390386 0.0567314 0 GO:0008989 rRNA (guanine-N1-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.151123 0 0 0 0 0 GO:0008993 rhamnulokinase activity molecular_function Escherichia Escherichia coli 0.0552431 0 0 0 0 0 GO:0008998 ribonucleoside-triphosphate reductase activity molecular_function Escherichia Escherichia coli 0.0487782 0 0 0 0 0.0325329 GO:0008998 ribonucleoside-triphosphate reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0891473 0.213999 0.268834 0.0912236 0.059683 0.0889643 GO:0008999 ribosomal-protein-alanine N-acetyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 7.87636 3.88773 3.60458 1.22769 3.346 1.58729 GO:0009001 serine O-acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.70935 12.2732 6.72188 25.6384 18.8175 41.6856 GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity molecular_function Clostridium Clostridium thermocellum 11.4678 41.1042 43.0798 77.3469 76.4782 95.1614 GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity molecular_function Escherichia Escherichia coli 0.129832 0 0.380833 0 0 0 GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity molecular_function Clostridium Clostridium thermocellum 1.16504 22.054 19.0003 37.3825 34.1225 33.9458 GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.791777 1.45729 1.46866 0.560821 0.434579 0.4054 GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity molecular_function Escherichia Escherichia coli 0.331775 0 0.071268 0 0 0 GO:0009010 sorbitol-6-phosphate 2-dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0770925 0 0 0 0 0 GO:0009011 starch synthase activity molecular_function Clostridium Clostridium thermocellum 3.25983 22.9129 16.1641 176.137 163.855 141.991 GO:0009011 starch synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 25.1303 18.9059 16.8647 23.5169 27.9081 19.338 GO:0009011 starch synthase activity molecular_function Escherichia Escherichia coli 0.0567743 0 0 0 0 0 GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity molecular_function Escherichia Escherichia coli 0.0781861 0 0 0 0 0 GO:0009014 succinyl-diaminopimelate desuccinylase activity molecular_function Escherichia Escherichia coli 0.0496046 0 0 0 0 0 GO:0009017 succinylglutamate desuccinylase activity molecular_function Escherichia Escherichia coli 0.118701 0 0 0 0 0 GO:0009018 sucrose phosphorylase activity molecular_function Escherichia Escherichia coli 0 0 0.165946 0 0 0 GO:0009022 tRNA nucleotidyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.09874 22.0906 19.5707 49.8565 44.7456 41.7264 GO:0009022 tRNA nucleotidyltransferase activity molecular_function Escherichia Escherichia coli 0.171465 0 0 0 0 0 GO:0009024 tagatose-6-phosphate kinase activity molecular_function Clostridium Clostridium thermocellum 9.86686 28.7165 21.6438 133.033 107.045 143.081 GO:0009024 tagatose-6-phosphate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 125.074 105.814 111.725 74.0842 99.1241 73.0471 GO:0009025 tagatose-bisphosphate aldolase activity molecular_function Escherichia Escherichia coli 0.103414 0 0 0 0 0 GO:0009026 tagaturonate reductase activity molecular_function Escherichia Escherichia coli 0.037331 0 0 0 0 0.0489934 GO:0009027 tartrate dehydrogenase activity molecular_function Escherichia Escherichia coli 0 0 0.0963923 0 0 0 GO:0009028 tartronate-semialdehyde synthase activity molecular_function Escherichia Escherichia coli 0.0297725 0 0.225667 0 0 0.0197914 GO:0009030 thiamine-phosphate kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.732208 0.75966 1.07344 1.04805 0.508174 0.872342 GO:0009032 thymidine phosphorylase activity molecular_function Escherichia Escherichia coli 0.0414384 0 0 0 0 0 GO:0009033 trimethylamine-N-oxide reductase activity molecular_function Escherichia Escherichia coli 0.023818 0 0 0 0 0 GO:0009034 tryptophanase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 7.95642 2.92195 5.68913 0.332439 0.870287 2.26893 GO:0009034 tryptophanase activity molecular_function Escherichia Escherichia coli 0.0897792 0 0.299687 0 0 0 GO:0009035 Type I site-specific deoxyribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0504309 0.145202 0.0935957 0.0687908 0.0825362 0.0671032 GO:0009036 Type II site-specific deoxyribonuclease activity molecular_function Escherichia Escherichia coli 0 0 0.0195762 0 0 0 GO:0009037 tyrosine-based site-specific recombinase activity molecular_function Clostridium Clostridium thermocellum 2.79817 18.9956 17.6943 53.5995 57.7881 90.0056 GO:0009037 tyrosine-based site-specific recombinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.2546 16.0043 18.9494 12.4801 8.90857 9.72214 GO:0009037 tyrosine-based site-specific recombinase activity molecular_function Escherichia Escherichia coli 0.128568 0 0 0 0 0 GO:0009037 tyrosine-based site-specific recombinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123683 0.356213 0.401717 0.253103 0.386681 0.493718 GO:0009039 urease activity molecular_function Clostridium Clostridium thermocellum 0.0309634 0.628694 1.87584 1.02724 1.13578 2.2221 GO:0009045 xylose isomerase activity molecular_function Escherichia Escherichia coli 0 0 0.0769063 0 0 0 GO:0009052 pentose-phosphate shunt, non-oxidative branch biological_process Escherichia Escherichia coli 0.24479 0 0.0933701 0 0 0 GO:0009052 pentose-phosphate shunt, non-oxidative branch biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.366068 1.3183 1.01918 1.49649 0.69458 0.912054 GO:0009055 electron carrier activity molecular_function Clostridium Clostridium thermocellum 155.433 2025.06 1177.37 6036.32 4225.39 7111.34 GO:0009055 electron carrier activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6105.26 15041.1 12849.1 5663.86 6300.71 7716.41 GO:0009055 electron carrier activity molecular_function Escherichia Escherichia coli 1.71973 0 2.40106 0 0 0.239211 GO:0009055 electron carrier activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 3.52377 21.4136 10.7144 9.17578 3.57768 9.9522 GO:0009056 catabolic process biological_process Escherichia Escherichia coli 0.0648918 0 0.0618859 0 0 0 GO:0009058 biosynthetic process biological_process Clostridium Clostridium thermocellum 31.9919 1512.4 1300.19 810.889 863.893 937.324 GO:0009058 biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 161.844 67.3117 111.497 41.4137 45.1148 49.2434 GO:0009058 biosynthetic process biological_process Escherichia Escherichia coli 0.196571 0 0.340192 0 0 0.0869269 GO:0009058 biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.05381 2.9143 3.05997 3.37973 2.29367 5.24294 GO:0009059 macromolecule biosynthetic process biological_process Clostridium Clostridium thermocellum 0.0777973 0.0373389 0.0360851 0.37815 0.277906 0.129388 GO:0009060 aerobic respiration biological_process Escherichia Escherichia coli 0.19696 0 0 0 0 0.106654 GO:0009061 anaerobic respiration biological_process Escherichia Escherichia coli 0.288319 0 0.605102 0 0 0.0680087 GO:0009063 cellular amino acid catabolic process biological_process Escherichia Escherichia coli 0.139554 0 0.0742451 0 0 0 GO:0009073 aromatic amino acid family biosynthetic process biological_process Clostridium Clostridium thermocellum 33.1477 195.447 144.814 520.522 400.363 612.79 GO:0009073 aromatic amino acid family biosynthetic process biological_process Escherichia Escherichia coli 0.543123 0 0.0854314 0 0 0 GO:0009073 aromatic amino acid family biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.89888 5.53782 3.08843 1.50516 1.32659 2.37442 GO:0009082 branched-chain amino acid biosynthetic process biological_process Clostridium Clostridium thermocellum 5.75651 34.0291 23.5696 99.5964 78.3471 48.7481 GO:0009086 methionine biosynthetic process biological_process Clostridium Clostridium thermocellum 6.93494 45.9129 36.2113 124.122 135.236 151.264 GO:0009086 methionine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 10.4237 7.6758 5.06856 6.69897 8.77134 7.19531 GO:0009086 methionine biosynthetic process biological_process Escherichia Escherichia coli 0.273737 0 0.490126 0 0 0.0708545 GO:0009086 methionine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.45451 0.689369 0.753186 0.587432 0.161122 0.562341 GO:0009088 threonine biosynthetic process biological_process Clostridium Clostridium thermocellum 5.74762 35.8923 30.8092 120.435 128.656 122.88 GO:0009088 threonine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.274417 0.316447 0.10176 0.224826 0.637198 0.219193 GO:0009088 threonine biosynthetic process biological_process Escherichia Escherichia coli 0.0847725 0 0.15476 0 0 0 GO:0009088 threonine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.752016 2.01327 2.17133 2.31757 1.04152 1.82708 GO:0009089 lysine biosynthetic process via diaminopimelate biological_process Clostridium Clostridium thermocellum 12.8175 88.7074 87.6977 259.318 265.568 319.566 GO:0009089 lysine biosynthetic process via diaminopimelate biological_process Coprothermobacter Coprothermobacter proteolyticus 0.314908 0.47201 0.327066 0.26626 0.890384 0.353917 GO:0009089 lysine biosynthetic process via diaminopimelate biological_process Escherichia Escherichia coli 0.310703 0 0.298198 0 0 0.0822378 GO:0009089 lysine biosynthetic process via diaminopimelate biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.64706 2.75967 4.2727 4.35302 1.59384 3.74378 GO:0009090 homoserine biosynthetic process biological_process Escherichia Escherichia coli 0.0825366 0 0.0395132 0 0 0 GO:0009094 L-phenylalanine biosynthetic process biological_process Clostridium Clostridium thermocellum 2.97178 34.7949 21.2976 90.9433 79.4176 122.027 GO:0009094 L-phenylalanine biosynthetic process biological_process Escherichia Escherichia coli 0.14196 0 0 0 0 0 GO:0009094 L-phenylalanine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0861822 0 0 0.176379 0 0 GO:0009097 isoleucine biosynthetic process biological_process Clostridium Clostridium thermocellum 21.536 164.346 107.335 479.914 443.671 381.841 GO:0009097 isoleucine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.274417 0.316447 0.10176 0.224826 0.637198 0.219193 GO:0009097 isoleucine biosynthetic process biological_process Escherichia Escherichia coli 0.219757 0 0.115427 0 0 0.0414585 GO:0009097 isoleucine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.988008 2.11641 2.6657 3.91177 1.36168 2.36717 GO:0009098 leucine biosynthetic process biological_process Clostridium Clostridium thermocellum 16.6799 114.54 77.5037 335.963 262.374 199.657 GO:0009098 leucine biosynthetic process biological_process Escherichia Escherichia coli 0 0 0.115427 0 0 0.0414585 GO:0009098 leucine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.557462 2.28337 1.26343 1.79316 0.668537 0.961662 GO:0009099 valine biosynthetic process biological_process Clostridium Clostridium thermocellum 17.2058 142.842 87.5369 416.188 367.883 307.213 GO:0009099 valine biosynthetic process biological_process Escherichia Escherichia coli 0.219757 0 0.115427 0 0 0.0414585 GO:0009099 valine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.403982 1.70643 1.47989 2.6718 1.09014 1.55311 GO:0009102 biotin biosynthetic process biological_process Clostridium Clostridium thermocellum 0.202428 2.11296 0.97538 2.63837 3.71452 4.66925 GO:0009102 biotin biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 134.433 98.7123 165.423 101.135 109.359 59.248 GO:0009102 biotin biosynthetic process biological_process Escherichia Escherichia coli 0.302124 0 0.233516 0 0 0.11836 GO:0009103 lipopolysaccharide biosynthetic process biological_process Clostridium Clostridium thermocellum 10.1563 81.3977 65.9993 190.168 201.5 250.541 GO:0009103 lipopolysaccharide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 17.0894 14.1176 12.1005 34.4997 35.4584 19.8786 GO:0009103 lipopolysaccharide biosynthetic process biological_process Escherichia Escherichia coli 1.57053 0 1.7029 0 0 0.431368 GO:0009103 lipopolysaccharide biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0845295 0 0.209564 0.0577733 0.20162 0.0749939 GO:0009107 lipoate biosynthetic process biological_process Escherichia Escherichia coli 0.341083 0 0 0 0 0 GO:0009108 coenzyme biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.771678 0.763254 0.841504 1.98225 0.998638 1.40351 GO:0009113 purine nucleobase biosynthetic process biological_process Clostridium Clostridium thermocellum 3.5272 5.59043 3.38983 57.058 45.3974 35.3047 GO:0009113 purine nucleobase biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.387868 0.299551 0.499508 0.272179 0.405172 0.441555 GO:0009113 purine nucleobase biosynthetic process biological_process Escherichia Escherichia coli 0.220292 0 0 0 0 0 GO:0009113 purine nucleobase biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.213633 0.190708 0.804382 0.622524 0.299956 0.630899 GO:0009114 hypoxanthine catabolic process biological_process Escherichia Escherichia coli 0.0226271 0 0 0 0 0.060215 GO:0009115 xanthine catabolic process biological_process Escherichia Escherichia coli 0.0258109 0 0 0 0 0.0119007 GO:0009116 nucleoside metabolic process biological_process Clostridium Clostridium thermocellum 8.27283 59.0624 42.3816 175.58 174.184 202.063 GO:0009116 nucleoside metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 174.28 112.929 122.558 104.879 119.324 108.393 GO:0009116 nucleoside metabolic process biological_process Escherichia Escherichia coli 0.0710651 0 0 0 0 0 GO:0009116 nucleoside metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.659466 1.10458 1.90245 2.14612 0.396208 1.96278 GO:0009117 nucleotide metabolic process biological_process Escherichia Escherichia coli 0.208966 0 0 0 0 0 GO:0009117 nucleotide metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.321445 0.20471 0 0.656919 0.523974 0.141838 GO:0009143 nucleoside triphosphate catabolic process biological_process Clostridium Clostridium thermocellum 4.42378 27.4467 20.7349 59.5457 61.5965 71.5612 GO:0009143 nucleoside triphosphate catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 39.9694 79.6803 76.3232 58.9659 71.4159 58.7156 GO:0009143 nucleoside triphosphate catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.235117 0.564237 1.08797 0.960733 0.471539 1.87452 GO:0009152 purine ribonucleotide biosynthetic process biological_process Clostridium Clostridium thermocellum 2.56609 19.096 13.0901 53.6147 49.7911 53.0492 GO:0009156 ribonucleoside monophosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 7.68042 47.456 38.0977 129.847 130.084 128.96 GO:0009156 ribonucleoside monophosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 18.0708 16.0209 9.62597 23.7424 27.9475 19.6547 GO:0009156 ribonucleoside monophosphate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0685617 0.395372 0.191116 0.56194 0.0306445 0.548177 GO:0009163 nucleoside biosynthetic process biological_process Clostridium Clostridium thermocellum 0.42921 3.60526 1.94088 5.81473 5.79509 6.63769 GO:0009163 nucleoside biosynthetic process biological_process Escherichia Escherichia coli 0.052278 0 0.0484893 0 0 0 GO:0009165 nucleotide biosynthetic process biological_process Clostridium Clostridium thermocellum 12.3477 82.2144 59.9908 225.673 228.045 198.386 GO:0009165 nucleotide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 18.0708 16.0209 9.62597 23.7424 27.9475 19.6547 GO:0009165 nucleotide biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0685617 0.395372 0.191116 0.56194 0.0306445 0.548177 GO:0009166 nucleotide catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 311.041 63.3319 114.365 50.766 59.364 46.9924 GO:0009166 nucleotide catabolic process biological_process Escherichia Escherichia coli 0.0953934 0 0.161661 0 0 0.105683 GO:0009166 nucleotide catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0388622 0.111877 0 0.0397673 0 0.155097 GO:0009168 purine ribonucleoside monophosphate biosynthetic process biological_process Escherichia Escherichia coli 0.028533 0 0 0 0 0 GO:0009186 deoxyribonucleoside diphosphate metabolic process biological_process Escherichia Escherichia coli 0.0600067 0 0.0919719 0 0 0.0329857 GO:0009220 pyrimidine ribonucleotide biosynthetic process biological_process Clostridium Clostridium thermocellum 2.44795 10.3579 10.2479 25.2983 25.9347 35.8891 GO:0009220 pyrimidine ribonucleotide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.83 23.6456 13.4701 22.3517 31.1397 20.7496 GO:0009220 pyrimidine ribonucleotide biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.107302 0 0 0.219603 0.04792 0 GO:0009225 nucleotide-sugar metabolic process biological_process Clostridium Clostridium thermocellum 0 0 0 0.118854 0.285068 0.0772576 GO:0009225 nucleotide-sugar metabolic process biological_process Escherichia Escherichia coli 0 0 0.0963923 0 0 0.0691405 GO:0009228 thiamine biosynthetic process biological_process Clostridium Clostridium thermocellum 6.01661 51.0999 62.497 93.3511 94.9705 85.8493 GO:0009228 thiamine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 58.6956 41.7458 32.4765 34.8417 42.3967 30.9067 GO:0009228 thiamine biosynthetic process biological_process Escherichia Escherichia coli 0.100108 0 0.0458281 0 0 0 GO:0009228 thiamine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.11872 1.98694 1.88175 2.89438 1.18973 1.82805 GO:0009229 thiamine diphosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 3.19829 31.4616 52.9087 44.9853 47.9843 41.0127 GO:0009229 thiamine diphosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 5.71622 3.38575 2.93453 2.60064 2.69027 2.62158 GO:0009229 thiamine diphosphate biosynthetic process biological_process Escherichia Escherichia coli 0.100108 0 0.0458281 0 0 0 GO:0009229 thiamine diphosphate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.652126 1.2621 1.20249 1.87076 0.781305 1.10428 GO:0009231 riboflavin biosynthetic process biological_process Clostridium Clostridium thermocellum 13.9733 108.373 64.8526 319.996 247.155 217.613 GO:0009231 riboflavin biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.502 12.0994 6.78476 11.8856 12.0771 13.8432 GO:0009231 riboflavin biosynthetic process biological_process Escherichia Escherichia coli 0.165851 0 0.131891 0 0 0 GO:0009231 riboflavin biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.22342 2.71318 3.34955 4.06472 0.854639 3.84729 GO:0009234 menaquinone biosynthetic process biological_process Escherichia Escherichia coli 0 0 0.114796 0 0 0.106654 GO:0009236 cobalamin biosynthetic process biological_process Clostridium Clostridium thermocellum 5.23905 72.1388 49.4712 181.5 165.378 210.436 GO:0009236 cobalamin biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 19.8117 26.9325 13.3741 32.1034 34.5025 26.5592 GO:0009236 cobalamin biosynthetic process biological_process Escherichia Escherichia coli 0.429914 0 0.287553 0 0 0 GO:0009236 cobalamin biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.02844 3.50664 3.96489 3.89456 2.84171 5.37637 GO:0009239 enterobactin biosynthetic process biological_process Escherichia Escherichia coli 0.256505 0 0.463062 0 0 0 GO:0009242 colanic acid biosynthetic process biological_process Escherichia Escherichia coli 0.504479 0 0 0 0 0 GO:0009243 O antigen biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 3.26015 1.99964 4.92832 0.722029 1.58891 1.92271 GO:0009243 O antigen biosynthetic process biological_process Escherichia Escherichia coli 0.546404 0 0.349033 0 0 0.0691405 GO:0009243 O antigen biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.151244 0.0640362 0.395177 0.15989 0.20162 0.0749939 GO:0009244 lipopolysaccharide core region biosynthetic process biological_process Escherichia Escherichia coli 3.56912 0 2.71062 0 0 0.606904 GO:0009245 lipid A biosynthetic process biological_process Clostridium Clostridium thermocellum 8.27278 53.4787 39.6463 149.361 140.346 156.965 GO:0009245 lipid A biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 17.0894 14.1176 12.1005 34.4997 35.4584 19.8786 GO:0009245 lipid A biosynthetic process biological_process Escherichia Escherichia coli 0.51092 0 0.476594 0 0 0.0872827 GO:0009246 enterobacterial common antigen biosynthetic process biological_process Clostridium Clostridium thermocellum 4.60829 38.8424 31.8566 98.9275 100.38 84.5695 GO:0009246 enterobacterial common antigen biosynthetic process biological_process Escherichia Escherichia coli 0.630083 0 0.729189 0 0 0.069561 GO:0009246 enterobacterial common antigen biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.411541 1.18523 1.3379 0.63185 0.398466 0.410963 GO:0009247 glycolipid biosynthetic process biological_process Clostridium Clostridium thermocellum 2.04611 24.743 19.4994 37.4554 36.2616 38.6475 GO:0009249 protein lipoylation biological_process Clostridium Clostridium thermocellum 1.97208 5.6224 2.38586 18.0107 13.9535 12.5643 GO:0009249 protein lipoylation biological_process Coprothermobacter Coprothermobacter proteolyticus 79.0831 107.454 114.033 57.2569 68.2734 75.6252 GO:0009249 protein lipoylation biological_process Escherichia Escherichia coli 0.156275 0 0 0 0 0 GO:0009250 glucan biosynthetic process biological_process Escherichia Escherichia coli 0.282267 0 0.209203 0 0 0.0477969 GO:0009252 peptidoglycan biosynthetic process biological_process Clostridium Clostridium thermocellum 51.5267 297.611 267.757 727.587 659.583 717.691 GO:0009252 peptidoglycan biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 260.398 247.371 193.464 222.784 238.3 185.998 GO:0009252 peptidoglycan biosynthetic process biological_process Escherichia Escherichia coli 1.38905 0 0.960495 0 0 0.476222 GO:0009253 peptidoglycan catabolic process biological_process Clostridium Clostridium thermocellum 7.10339 23.5058 19.0309 126.018 116.203 118.523 GO:0009253 peptidoglycan catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.0948 12.6157 10.4638 7.60829 8.64425 9.36065 GO:0009253 peptidoglycan catabolic process biological_process Escherichia Escherichia coli 0.212782 0 0 0 0 0.312523 GO:0009254 peptidoglycan turnover biological_process Clostridium Clostridium thermocellum 1.35245 3.64138 2.19357 9.87297 8.4925 11.1669 GO:0009254 peptidoglycan turnover biological_process Coprothermobacter Coprothermobacter proteolyticus 29.3339 38.3753 20.3505 25.8515 35.8054 29.1819 GO:0009254 peptidoglycan turnover biological_process Escherichia Escherichia coli 0.46987 0 0.0737038 0 0 0.199693 GO:0009263 deoxyribonucleotide biosynthetic process biological_process Escherichia Escherichia coli 0.0600067 0 0 0 0 0 GO:0009264 deoxyribonucleotide catabolic process biological_process Clostridium Clostridium thermocellum 2.90613 26.5489 20.1626 70.8073 50.647 71.5258 GO:0009264 deoxyribonucleotide catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 33.9091 24.7874 17.0391 25.9841 31.4897 28.5441 GO:0009264 deoxyribonucleotide catabolic process biological_process Escherichia Escherichia coli 0.0771654 0 0 0 0 0.060215 GO:0009264 deoxyribonucleotide catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.370175 0.347438 0.257738 0.142033 0.0826881 0.18514 GO:0009266 response to temperature stimulus biological_process Escherichia Escherichia coli 0.280031 0 0.374338 0 0 0.123535 GO:0009267 cellular response to starvation biological_process Coprothermobacter Coprothermobacter proteolyticus 2264.11 440.619 906.906 318.673 321.72 232.447 GO:0009267 cellular response to starvation biological_process Escherichia Escherichia coli 0 0 0 0 0 0.324003 GO:0009268 response to pH biological_process Escherichia Escherichia coli 0.613604 0 1.6706 0 0 0.175277 GO:0009271 phage shock biological_process Escherichia Escherichia coli 0.0802034 0 0 0 0 0 GO:0009273 peptidoglycan-based cell wall biogenesis biological_process Escherichia Escherichia coli 0.10949 0 0 0 0 0 GO:0009290 DNA import into cell involved in transformation biological_process Escherichia Escherichia coli 0.201602 0 0.187552 0 0 0 GO:0009294 DNA mediated transformation biological_process Clostridium Clostridium thermocellum 0.857374 9.97961 8.14846 21.3218 22.7481 23.4977 GO:0009294 DNA mediated transformation biological_process Coprothermobacter Coprothermobacter proteolyticus 1.5961 1.49617 2.16822 1.03557 0.590536 0.569488 GO:0009294 DNA mediated transformation biological_process Escherichia Escherichia coli 0.111434 0 0 0 0 0 GO:0009297 pilus assembly biological_process Escherichia Escherichia coli 0.242579 0 0.136672 0 0 0.267701 GO:0009298 GDP-mannose biosynthetic process biological_process Escherichia Escherichia coli 0.03981 0 0 0 0 0 GO:0009305 protein biotinylation biological_process Escherichia Escherichia coli 0.178999 0 0 0 0 0 GO:0009306 protein secretion biological_process Clostridium Clostridium thermocellum 116.884 557.649 443.588 1997.09 1670.65 2125.64 GO:0009306 protein secretion biological_process Coprothermobacter Coprothermobacter proteolyticus 759.094 460.013 447.271 370.495 410.122 328.987 GO:0009306 protein secretion biological_process Escherichia Escherichia coli 1.266 0 0.393824 0 0 0.117681 GO:0009307 DNA restriction-modification system biological_process Escherichia Escherichia coli 0 0 0.14213 0 0 0 GO:0009307 DNA restriction-modification system biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0504309 2.26862 0.680068 0.43274 0.435274 0.803427 GO:0009308 amine metabolic process biological_process Escherichia Escherichia coli 0.0686346 0 0 0 0 0 GO:0009372 quorum sensing biological_process Clostridium Clostridium thermocellum 13.8842 61.0926 57.1465 116.659 97.5631 177.173 GO:0009372 quorum sensing biological_process Escherichia Escherichia coli 0.16534 0 0.492967 0 0 0 GO:0009378 four-way junction helicase activity molecular_function Clostridium Clostridium thermocellum 1.22587 14.6422 11.6968 34.7141 38.6659 39.8676 GO:0009378 four-way junction helicase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.1839 32.6019 22.1902 27.65 26.8396 13.5117 GO:0009378 four-way junction helicase activity molecular_function Escherichia Escherichia coli 0.112917 0 0.104737 0 0 0 GO:0009381 excinuclease ABC activity molecular_function Clostridium Clostridium thermocellum 9.64752 26.388 25.182 61.711 59.6319 57.0161 GO:0009381 excinuclease ABC activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 23.0826 22.3576 15.9566 24.5116 23.5278 18.7787 GO:0009381 excinuclease ABC activity molecular_function Escherichia Escherichia coli 0.111604 0 0 0 0 0 GO:0009381 excinuclease ABC activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.230475 0.140161 0.308573 0.217042 0.168263 0.332023 GO:0009389 dimethyl sulfoxide reductase activity molecular_function Escherichia Escherichia coli 0.102199 0 0.252686 0 0 0 GO:0009395 phospholipid catabolic process biological_process Escherichia Escherichia coli 0 0 0.244476 0 0 0.175277 GO:0009396 folic acid-containing compound biosynthetic process biological_process Clostridium Clostridium thermocellum 10.5117 54.8254 42.4318 143.959 133.887 149.189 GO:0009396 folic acid-containing compound biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 138.25 57.6078 89.4148 49.3146 66.0765 56.4692 GO:0009396 folic acid-containing compound biosynthetic process biological_process Escherichia Escherichia coli 0.0648918 0 0 0 0 0 GO:0009398 FMN biosynthetic process biological_process Clostridium Clostridium thermocellum 2.18476 13.2453 14.3414 40.3507 33.9304 35.5191 GO:0009398 FMN biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.502 12.0994 6.78476 11.8856 12.0771 13.8432 GO:0009398 FMN biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.204106 0.338159 0 0.295319 GO:0009399 nitrogen fixation biological_process Coprothermobacter Coprothermobacter proteolyticus 89.8945 66.5803 94.2909 35.8416 41.9936 38.8995 GO:0009399 nitrogen fixation biological_process Escherichia Escherichia coli 0.316439 0 0.0358144 0 0 0 GO:0009399 nitrogen fixation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.18881 1.30317 1.201 2.57595 1.33749 3.28104 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system biological_process Coprothermobacter Coprothermobacter proteolyticus 1540.98 667.246 890.113 537.755 597.365 456.607 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system biological_process Escherichia Escherichia coli 2.54014 0 3.19935 0 0 0.533462 GO:0009403 toxin biosynthetic process biological_process Clostridium Clostridium thermocellum 4.60246 18.8217 6.64475 57.9102 57.4213 67.5969 GO:0009405 pathogenesis biological_process Clostridium Clostridium thermocellum 29.8344 141.85 161.68 252.317 242.793 327.098 GO:0009405 pathogenesis biological_process Escherichia Escherichia coli 1.34907 0 0.67231 0 0 0.273199 GO:0009407 toxin catabolic process biological_process Escherichia Escherichia coli 0.050601 0 0 0 0 0 GO:0009408 response to heat biological_process Clostridium Clostridium thermocellum 2.69197 26.4416 31.0869 38.6303 41.4569 45.3407 GO:0009408 response to heat biological_process Coprothermobacter Coprothermobacter proteolyticus 106.328 24.3363 42.4334 17.9339 28.2875 32.3251 GO:0009408 response to heat biological_process Escherichia Escherichia coli 0.496532 0 0 0 0 0.267022 GO:0009408 response to heat biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.049556 0.190288 0.458416 0.202692 0.13267 0.395472 GO:0009411 response to UV biological_process Clostridium Clostridium thermocellum 0.208553 0.972351 0.331306 3.19807 3.98802 2.61492 GO:0009411 response to UV biological_process Escherichia Escherichia coli 0 0 0 0 0 0.175277 GO:0009423 chorismate biosynthetic process biological_process Clostridium Clostridium thermocellum 28.9614 161.878 112.064 469.11 355.165 557.325 GO:0009423 chorismate biosynthetic process biological_process Escherichia Escherichia coli 0.543123 0 0 0 0 0 GO:0009423 chorismate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.6265 4.61047 2.46768 1.32797 0.950349 1.73249 GO:0009432 SOS response biological_process Clostridium Clostridium thermocellum 26.7801 153.199 114.421 313.661 317.219 320.542 GO:0009432 SOS response biological_process Coprothermobacter Coprothermobacter proteolyticus 116.093 153.077 177.261 105.008 112.728 92.5415 GO:0009432 SOS response biological_process Escherichia Escherichia coli 2.01267 0 0.768973 0 0 0.36585 GO:0009432 SOS response biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.230475 0.140161 0.308573 0.217042 0.168263 0.332023 GO:0009435 NAD biosynthetic process biological_process Clostridium Clostridium thermocellum 12.187 89.5575 75.878 198.921 190.362 190.331 GO:0009435 NAD biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 199.535 124.645 146.6 98.1614 113.467 78.0325 GO:0009435 NAD biosynthetic process biological_process Escherichia Escherichia coli 0.144488 0 0 0 0 0.0614116 GO:0009435 NAD biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.308224 0.904721 2.07534 1.47793 0.924696 2.21819 GO:0009436 glyoxylate catabolic process biological_process Escherichia Escherichia coli 0.0297725 0 0.225667 0 0 0.0197914 GO:0009437 carnitine metabolic process biological_process Escherichia Escherichia coli 0.988494 0 0.590893 0 0 0.130229 GO:0009438 methylglyoxal metabolic process biological_process Escherichia Escherichia coli 0 0 0.0997753 0 0 0.170588 GO:0009443 pyridoxal 5'-phosphate salvage biological_process Escherichia Escherichia coli 0.0681243 0 0 0 0 0 GO:0009446 putrescine biosynthetic process biological_process Escherichia Escherichia coli 0.0266129 0 0.0493915 0 0 0 GO:0009447 putrescine catabolic process biological_process Escherichia Escherichia coli 0.0785507 0 0 0 0 0.0828522 GO:0009450 gamma-aminobutyric acid catabolic process biological_process Escherichia Escherichia coli 0.099865399999999993 0 0.079748 0 0 0 GO:0009451 RNA modification biological_process Clostridium Clostridium thermocellum 2.68205 21.4866 17.6564 50.7099 42.5184 45.7352 GO:0009451 RNA modification biological_process Coprothermobacter Coprothermobacter proteolyticus 13.5997 11.3454 7.56375 15.5999 16.5164 19.1874 GO:0009451 RNA modification biological_process Escherichia Escherichia coli 0.133697 0 0 0 0 0 GO:0009451 RNA modification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.124479 0.240552 0.0442191 0 0.229186 GO:0009605 response to external stimulus biological_process Escherichia Escherichia coli 0.270674 0 0 0 0 0.126833 GO:0009607 response to biotic stimulus biological_process Escherichia Escherichia coli 0.114108 0 0 0 0 0 GO:0009617 response to bacterium biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0009636 response to toxic substance biological_process Coprothermobacter Coprothermobacter proteolyticus 5102.29 13939.3 11938.1 4792.25 5139.37 6668.11 GO:0009636 response to toxic substance biological_process Escherichia Escherichia coli 0.231861 0 0 0 0 0 GO:0009637 response to blue light biological_process Escherichia Escherichia coli 0.0457645 0 0 0 0 0.0304632 GO:0009658 chloroplast organization biological_process Coprothermobacter Coprothermobacter proteolyticus 32.7965 30.3904 25.2548 30.4867 36.1375 23.6265 GO:0009678 hydrogen-translocating pyrophosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 329.96 76.3616 128.399 27.1477 34.4745 46.8286 GO:0009735 response to cytokinin biological_process Clostridium Clostridium thermocellum 4.49499 69.5112 74.5146 100.37 105.77 104.092 GO:0009735 response to cytokinin biological_process Coprothermobacter Coprothermobacter proteolyticus 50.2588 66.8372 80.2765 34.749 48.1546 40.7722 GO:0009758 carbohydrate utilization biological_process Escherichia Escherichia coli 0.0941296 0 0 0 0 0 GO:0009791 post-embryonic development biological_process Coprothermobacter Coprothermobacter proteolyticus 32.7965 30.3904 25.2548 30.4867 36.1375 23.6265 GO:0009845 seed germination biological_process Coprothermobacter Coprothermobacter proteolyticus 32.7965 30.3904 25.2548 30.4867 36.1375 23.6265 GO:0009847 spore germination biological_process Clostridium Clostridium thermocellum 0.720567 4.40828 4.72669 11.3903 13.797 20.0624 GO:0009882 blue light photoreceptor activity molecular_function Escherichia Escherichia coli 0.0457645 0 0 0 0 0.0304632 GO:0009927 histidine phosphotransfer kinase activity molecular_function Escherichia Escherichia coli 0.0862308 0 0.0824995 0 0 0.0390654 GO:0009970 cellular response to sulfate starvation biological_process Escherichia Escherichia coli 0 0 0.111097 0 0 0 GO:0009982 pseudouridine synthase activity molecular_function Clostridium Clostridium thermocellum 20.2392 92.4515 82.796 183.884 183.662 250.521 GO:0009982 pseudouridine synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 49.0558 37.5712 26.2759 39.8535 39.3993 31.4734 GO:0009982 pseudouridine synthase activity molecular_function Escherichia Escherichia coli 0.292475 0 0 0 0 0 GO:0009982 pseudouridine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.752551 0.87625 0.922425 0.569526 0.745864 0.887056 GO:0009992 cellular water homeostasis biological_process Escherichia Escherichia coli 0.0545626 0 0 0 0 0.0773546 GO:0010033 response to organic substance biological_process Escherichia Escherichia coli 0.098796 0 0.0815072 0 0 0 GO:0010038 response to metal ion biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.444106 0 0 GO:0010041 response to iron(III) ion biological_process Escherichia Escherichia coli 0 0 0.287237 0 0 0.103032 GO:0010043 response to zinc ion biological_process Escherichia Escherichia coli 0.151682 0 0 0 0 0 GO:0010045 response to nickel cation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.535151 0.341931 0.68724 0.364397 1.03378 0.533074 GO:0010124 phenylacetate catabolic process biological_process Clostridium Clostridium thermocellum 7.04363 28.6383 26.3849 80.0477 75.0165 65.8896 GO:0010124 phenylacetate catabolic process biological_process Escherichia Escherichia coli 0.203546 0 0.112495 0 0 0 GO:0010124 phenylacetate catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.294541 0.161957 0.702937 0.517149 0.187709 0.47619 GO:0010133 proline catabolic process to glutamate biological_process Coprothermobacter Coprothermobacter proteolyticus 8.8536 7.17812 8.30773 2.55001 3.206 4.34188 GO:0010133 proline catabolic process to glutamate biological_process Escherichia Escherichia coli 0.00636766 0 0 0 0 0 GO:0010181 FMN binding molecular_function Clostridium Clostridium thermocellum 32.9676 282.972 230.348 778.784 706.429 824.017 GO:0010181 FMN binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 44.39 64.6538 47.2545 48.6192 55.3004 43.0751 GO:0010181 FMN binding molecular_function Escherichia Escherichia coli 0.890768 0 1.2766 0 0 0.109014 GO:0010181 FMN binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.54802 3.90453 2.76394 3.99064 1.79507 4.1756 GO:0010188 response to microbial phytotoxin biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0010212 response to ionizing radiation biological_process Escherichia Escherichia coli 0.0778216 0 0 0 0 0.0845339 GO:0010285 L,L-diaminopimelate aminotransferase activity molecular_function Clostridium Clostridium thermocellum 0.112212 6.54863 14.2787 14.7861 20.8913 21.728 GO:0010285 L,L-diaminopimelate aminotransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0448896 0.129286 0.499643 0.0459351 0.0400853 0.0298488 GO:0010312 detoxification of zinc ion biological_process Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0010340 carboxyl-O-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0 0.465523 0.128508 0.212515 0.618316 0.2764 GO:0010438 cellular response to sulfur starvation biological_process Escherichia Escherichia coli 0.0481949 0 0.0452868 0 0 0.0217641 GO:0010468 regulation of gene expression biological_process Escherichia Escherichia coli 0.0281198 0 0 0 0 0 GO:0010498 proteasomal protein catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.61894 3.5695 1.70137 1.70878 0.959095 2.58087 GO:0010501 RNA secondary structure unwinding biological_process Escherichia Escherichia coli 0.0880779 0 0.0645923 0 0 0.0529711 GO:0010608 posttranscriptional regulation of gene expression biological_process Escherichia Escherichia coli 0.108493 0 0 0 0 0 GO:0010628 positive regulation of gene expression biological_process Escherichia Escherichia coli 0.0309148 0 0 0 0 0.0822378 GO:0010629 negative regulation of gene expression biological_process Escherichia Escherichia coli 0 0 0 0 0 0.112378 GO:0010795 regulation of ubiquinone biosynthetic process biological_process Escherichia Escherichia coli 0.130416 0 0.0604876 0 0 0 GO:0010967 regulation of polyamine biosynthetic process biological_process Escherichia Escherichia coli 0.0983099 0 0.072937 0 0 0 GO:0010974 negative regulation of barrier septum assembly biological_process Escherichia Escherichia coli 0.108615 0 0 0 0 0.144684 GO:0015020 glucuronosyltransferase activity molecular_function Escherichia Escherichia coli 0.0280226 0 0 0 0 0 GO:0015031 protein transport biological_process Clostridium Clostridium thermocellum 5.68761 59.1771 35.7814 143.815 136.364 129.333 GO:0015031 protein transport biological_process Coprothermobacter Coprothermobacter proteolyticus 7.12833 14.9748 13.5304 19.2067 19.5046 16.6573 GO:0015031 protein transport biological_process Escherichia Escherichia coli 0.951139 0 2.04494 0 0 0.382925 GO:0015031 protein transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.884445 1.58485 0 0 GO:0015035 protein disulfide oxidoreductase activity molecular_function Clostridium Clostridium thermocellum 69.7436 705.845 554.929 1695.74 1289.88 2098.5 GO:0015035 protein disulfide oxidoreductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 74.529 175.079 237.509 129.362 148.538 101.234 GO:0015035 protein disulfide oxidoreductase activity molecular_function Escherichia Escherichia coli 0.710675 0 0.532526 0 0 0 GO:0015035 protein disulfide oxidoreductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.01528 4.75987 2.86529 2.80575 0.970207 1.94706 GO:0015036 disulfide oxidoreductase activity molecular_function Escherichia Escherichia coli 0.101688 0 0 0 0 0 GO:0015074 DNA integration biological_process Clostridium Clostridium thermocellum 15.0104 115.421 74.3284 140.258 108.481 112.067 GO:0015074 DNA integration biological_process Coprothermobacter Coprothermobacter proteolyticus 9.85029 12.0532 10.9526 11.5675 15.2489 15.3099 GO:0015074 DNA integration biological_process Escherichia Escherichia coli 2.53836 0 0.64448 0 0 0.316759 GO:0015075 ion transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 70.4932 19.0135 31.7417 17.3804 35.2874 19.0254 GO:0015075 ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0771654 0 0 0 0 0.102676 GO:0015078 hydrogen ion transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 44.9564 683.11 435.448 1010.09 966.511 862.389 GO:0015078 hydrogen ion transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 201.028 127.136 107.719 156.35 188.081 133.627 GO:0015078 hydrogen ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0.501177 0 0 0 GO:0015078 hydrogen ion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.557049 0.252084 0.9268 1.05191 0.681059 0.882949 GO:0015079 potassium ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.311481 0 0.0892204 0 0 0.109694 GO:0015079 potassium ion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0960739 0.73609 0.266533 0.343382 0.256746 0.766432 GO:0015081 sodium ion transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 2.38104 17.75 13.8523 29.105 39.5093 53.9613 GO:0015081 sodium ion transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 57.6596 26.7981 29.3111 17.74 17.493 12.5063 GO:0015081 sodium ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.207557 0 0.177403 0 0 0 GO:0015087 cobalt ion transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.24621 1.08189 1.3757 1.00187 0.476835 0.789716 GO:0015087 cobalt ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.714855 0 0.0220119 0 0 0 GO:0015087 cobalt ion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0 0.747707 GO:0015091 ferric iron transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0223597 0 0 0 0 0 GO:0015093 ferrous iron transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 0 0 0 0.0248701 0.0976414 0.048476 GO:0015093 ferrous iron transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.08462 5.46879 4.18758 3.62868 3.38264 2.09136 GO:0015093 ferrous iron transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.135349 0 0 0 0 0 GO:0015093 ferrous iron transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.120184 2.76513 1.81531 0.517871 0.273739 0.410607 GO:0015094 lead ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0015095 magnesium ion transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 1.51708 7.00716 5.29025 20.5804 20.1047 21.6624 GO:0015095 magnesium ion transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.24621 1.08189 1.3757 1.00187 0.476835 0.789716 GO:0015095 magnesium ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.691134 0 0 0 0 0 GO:0015098 molybdate ion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.436355 0.566151 0 1.2966 0.352889 0.449155 GO:0015099 nickel cation transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.120232 0 0.0220119 0 0 0.0478292 GO:0015103 inorganic anion transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 0.241364 5.40574 5.57221 1.34403 2.56268 2.1735 GO:0015103 inorganic anion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.207727 0 0.192785 0 0 0 GO:0015103 inorganic anion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.295351 0.0951744 0.209879 0 0.136405 GO:0015105 arsenite transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0.0395583 0 0 0.185755 GO:0015109 chromate transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.238277 0.228794 0.110556 0.121913 0.212775 0 GO:0015112 nitrate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.15331 0 0 0 0 0 GO:0015113 nitrite transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.15331 0 0 0 0 0 GO:0015116 sulfate transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.0751824 0 0 GO:0015128 gluconate transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 210.675 295.704 262.819 84.4667 105.365 123.045 GO:0015128 gluconate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.285791 0 0.0761395 0 0 0.164637 GO:0015129 lactate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.161403 0 0.119757 0 0 0 GO:0015143 urate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0374282 0 0.0694638 0 0 0 GO:0015144 carbohydrate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.525138 0 0.245965 0 0 0.178543 GO:0015145 monosaccharide transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.4668 15.9374 18.6096 2.48895 4.0153 5.36667 GO:0015145 monosaccharide transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.366432 0 0.113984 0 0 0.174565 GO:0015153 rhamnose transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0960253 0 0.119351 0 0 0 GO:0015159 polysaccharide transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.147258 0 0.186966 0 0 0 GO:0015169 glycerol-3-phosphate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0724747 0 0 0 0 0 GO:0015171 amino acid transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.37314 0 0.11042 0 0 3.23389 GO:0015173 aromatic amino acid transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.246224 0 0.199641 0 0 0.134886 GO:0015179 L-amino acid transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.460343 0 0.523098 0 0 0.179351 GO:0015181 arginine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0498962 0 0 0 0 0 GO:0015185 gamma-aminobutyric acid transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0388622 0 0 0 0 0 GO:0015188 L-isoleucine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.145411 0 0 0 0 0 GO:0015190 L-leucine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.246832 0 0 0 0 0 GO:0015197 peptide transporter activity molecular_function Escherichia Escherichia coli 0.233756 0 0 0 0 0 GO:0015199 amino-acid betaine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.265619 0 0 0 0 0 GO:0015205 nucleobase transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.186874 0 0 0 0 0 GO:0015207 adenine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.123489 0 0.151873 0 0 0.054588 GO:0015208 guanine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0803249 0 0 0 0 0.0530681 GO:0015210 uracil transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0548468 GO:0015211 purine nucleoside transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.141109 0 0 0 0 0 GO:0015212 cytidine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015213 uridine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015214 pyrimidine nucleoside transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015218 pyrimidine nucleotide transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0548468 GO:0015220 choline transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.265619 0 0 0 0 0 GO:0015221 lipopolysaccharide transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0.416332 0 0 0 GO:0015225 biotin transporter activity molecular_function Clostridium Clostridium thermocellum 8.34706 193.014 226.224 269.89 317.035 470.798 GO:0015225 biotin transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.981519 4.00614 2.05031 1.63257 2.30155 3.91462 GO:0015225 biotin transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.150029 0.144035 0.278442 0.230049 0.0669752 0.0997978 GO:0015230 FAD transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0959524 0 0 0 0 0.0780984 GO:0015232 heme transporter activity molecular_function Escherichia Escherichia coli 0.237475 0 0 0 0 0.0756407 GO:0015233 pantothenate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.111993 0 0 0 0 0 GO:0015234 thiamine transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 35.435 13.8448 25.477 9.90637 9.92735 6.56379 GO:0015235 cobalamin transporter activity molecular_function Escherichia Escherichia coli 0.0914562 0 0.0530902 0 0 0.0381599 GO:0015238 drug transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 5.61193 45.0619 27.6101 112.842 109.7 124.834 GO:0015238 drug transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.32465 3.04886 2.80652 8.9609 7.80836 5.64546 GO:0015238 drug transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.824831 0 0.178802 0 0 0.267798 GO:0015238 drug transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.260612 0.0385524 0.149212 0.12343 0.125638 0.133721 GO:0015288 porin activity molecular_function Escherichia Escherichia coli 1.54856 0 0.928875 0 0 0.781017 GO:0015291 secondary active transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0773355 0 0 0 0 0 GO:0015292 uniporter activity molecular_function Escherichia Escherichia coli 0 0 0.0807855 0 0 0 GO:0015293 symporter activity molecular_function Escherichia Escherichia coli 1.78885 0 0.82071 0 0 0.350036 GO:0015294 solute:cation symporter activity molecular_function Escherichia Escherichia coli 0.36388 0 0 0 0 0.0281348 GO:0015295 solute:proton symporter activity molecular_function Escherichia Escherichia coli 0.0392997 0 0 0 0 0.0261298 GO:0015297 antiporter activity molecular_function Clostridium Clostridium thermocellum 5.85329 50.4677 33.1823 114.186 112.263 127.008 GO:0015297 antiporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.32465 3.04886 2.80652 8.9609 7.80836 5.64546 GO:0015297 antiporter activity molecular_function Escherichia Escherichia coli 1.32963 0 0.700502 0 0 0.359447 GO:0015297 antiporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.260612 0.333903 0.244386 0.333309 0.125638 0.270127 GO:0015299 solute:proton antiporter activity molecular_function Clostridium Clostridium thermocellum 0.0469554 0.45096 0.348627 1.0571 1.06906 1.84325 GO:0015299 solute:proton antiporter activity molecular_function Escherichia Escherichia coli 0.239079 0 0 0 0 0.0393888 GO:0015299 solute:proton antiporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.127426 0.06721 0.0324766 0.338035 0.0413441 0.123179 GO:0015307 drug:proton antiporter activity molecular_function Escherichia Escherichia coli 0.265619 0 0 0 0 0 GO:0015315 organophosphate:inorganic phosphate antiporter activity molecular_function Escherichia Escherichia coli 0.0724747 0 0 0 0 0 GO:0015321 sodium-dependent phosphate transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 10.2247 261.617 224.053 600.669 529.904 634.346 GO:0015321 sodium-dependent phosphate transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 89.9159 78.5431 74.0493 39.0499 46.2699 45.7423 GO:0015321 sodium-dependent phosphate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0655723 0 0 0 0 0 GO:0015333 peptide:proton symporter activity molecular_function Escherichia Escherichia coli 0.115323 0 0.253047 0 0 0 GO:0015343 siderophore transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0426293 0 0.117682 0 0 0 GO:0015385 sodium:proton antiporter activity molecular_function Escherichia Escherichia coli 0.151584 0 0.0323864 0 0 0 GO:0015386 potassium:proton antiporter activity molecular_function Escherichia Escherichia coli 0.151584 0 0 0 0 0 GO:0015388 potassium uptake transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0557049 0 0 0 0 0 GO:0015407 monosaccharide-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.0354596 0 0 0 0 0 GO:0015412 molybdate transmembrane-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.106914 0 0 0 0 0 GO:0015412 molybdate transmembrane-transporting ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.498786 0.0785896 0 0 GO:0015413 nickel-transporting ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.0733429 0 0 0 GO:0015415 phosphate ion transmembrane-transporting ATPase activity molecular_function Clostridium Clostridium thermocellum 0.52645 0.388931 0.299596 0.331593 0.759667 1.28874 GO:0015415 phosphate ion transmembrane-transporting ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.243484 0 0 0 GO:0015415 phosphate ion transmembrane-transporting ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.158851 0.152529 0.442223 0.0812756 0.14185 0.422831 GO:0015419 sulfate transmembrane-transporting ATPase activity molecular_function Clostridium Clostridium thermocellum 61.4377 791.322 688.592 1110.28 1083.96 1272.36 GO:0015419 sulfate transmembrane-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.229843 0 0.845654 0 0 0.189053 GO:0015420 cobalamin-transporting ATPase activity molecular_function Clostridium Clostridium thermocellum 1.74309 13.8545 11.2913 33.7485 31.6547 41.1753 GO:0015420 cobalamin-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.052278 0 0.0484893 0 0 0 GO:0015420 cobalamin-transporting ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.507371 0.464216 0.893196 0.726431 0.447297 1.43129 GO:0015424 amino acid-transporting ATPase activity molecular_function Clostridium Clostridium thermocellum 2.21653 7.02737 4.46553 13.6725 13.1167 12.4513 GO:0015424 amino acid-transporting ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.69913 1.65803 2.58974 0.210327 0.734318 0.547109 GO:0015424 amino acid-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.420971 0 0.0740646 0 0 0.103387 GO:0015430 glycerol-3-phosphate-transporting ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.0978357 0 0 0 GO:0015439 heme-transporting ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.192785 0 0 0 GO:0015444 magnesium-importing ATPase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.101479 GO:0015446 arsenite-transmembrane transporting ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0 0.31359 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 54.6744 346.477 215.63 1371.68 1105.27 1449.86 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 320.77 451.692 397.094 377.988 419.456 341.457 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.162011 0 0.0541727 0 0 0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.864349 4.36814 2.48701 0.723423 1.07795 GO:0015459 potassium channel regulator activity molecular_function Escherichia Escherichia coli 0.208748 0 0.176185 0 0 0.0427844 GO:0015473 fimbrial usher porin activity molecular_function Escherichia Escherichia coli 0.242579 0 0.136672 0 0 0.203735 GO:0015481 maltose transporting porin activity molecular_function Escherichia Escherichia coli 0.0408065 0 0 0 0 0 GO:0015487 melibiose:monovalent cation symporter activity molecular_function Escherichia Escherichia coli 0.142252 0 0.0880025 0 0 0.212208 GO:0015489 putrescine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0392997 0 0 0 0 0.0261298 GO:0015496 putrescine:ornithine antiporter activity molecular_function Escherichia Escherichia coli 0.103876 0 0 0 0 0 GO:0015499 formate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.139019 0 0 0 0 0 GO:0015501 glutamate:sodium symporter activity molecular_function Escherichia Escherichia coli 0.23327 0 0.0854314 0 0 0.0613145 GO:0015503 glutathione-regulated potassium exporter activity molecular_function Escherichia Escherichia coli 0.132068 0 0 0 0 0.0393888 GO:0015513 nitrite uptake transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.143588 0 0 0 0 0 GO:0015517 galactose:proton symporter activity molecular_function Escherichia Escherichia coli 0.0410252 0 0 0 0 0.0554289 GO:0015518 arabinose:proton symporter activity molecular_function Escherichia Escherichia coli 0.0410252 0 0 0 0 0.0554289 GO:0015527 glycerol-phosphate:inorganic phosphate antiporter activity molecular_function Escherichia Escherichia coli 0.0724747 0 0 0 0 0 GO:0015535 fucose:proton symporter activity molecular_function Escherichia Escherichia coli 0.0410252 0 0 0 0 0.0554289 GO:0015538 sialic acid:proton symporter activity molecular_function Escherichia Escherichia coli 0.0194189 0 0 0 0 0.103387 GO:0015542 sugar efflux transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.117413 0 0 0 0 0.0624787 GO:0015546 sulfathiazole transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0266372 0 0.0494366 0 0 0 GO:0015556 C4-dicarboxylate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.167188 0 0.0759591 0 0 0 GO:0015558 p-aminobenzoyl-glutamate uptake transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0773355 0 0 0 0 0 GO:0015562 efflux transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.177055 0 0 0 0 0.0861185 GO:0015565 threonine efflux transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0443792 0 0 0 0 0 GO:0015568 L-idonate transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.145363 0 0 0 0 0.0552672 GO:0015572 N-acetylglucosamine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0270504 0 0 0 0 0 GO:0015574 trehalose transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0383275 0 0 0 0 0.0431401 GO:0015577 galactitol transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.122468 0 0 0 0 0 GO:0015591 D-ribose transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.122857 0 0.0664868 0 0 0.109467 GO:0015592 methylgalactoside transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.142252 0 0.0880025 0 0 0.212208 GO:0015594 putrescine-importing ATPase activity molecular_function Clostridium Clostridium thermocellum 1.49691 24.2779 16.7169 104.586 98.4303 50.9279 GO:0015594 putrescine-importing ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.0456927 0 0 0.065745 GO:0015595 spermidine-importing ATPase activity molecular_function Clostridium Clostridium thermocellum 1.49691 24.2779 16.7169 104.586 98.4303 50.9279 GO:0015595 spermidine-importing ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.0456927 0 0 0 GO:0015606 spermidine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.251401 0 0 0 0 0 GO:0015612 L-arabinose-importing ATPase activity molecular_function Clostridium Clostridium thermocellum 0.899031 2.69643 3.67495 3.0391 3.53656 4.19044 GO:0015612 L-arabinose-importing ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.518649 1.61411 2.1228 0.219578 0.28739 0.499668 GO:0015612 L-arabinose-importing ATPase activity molecular_function Escherichia Escherichia coli 0.26331 0 0.262158 0 0 0.109467 GO:0015614 D-xylose-importing ATPase activity molecular_function Escherichia Escherichia coli 0.0174503 0 0.0323864 0 0 0 GO:0015616 DNA translocase activity molecular_function Escherichia Escherichia coli 0.0241582 0 0 0 0 0 GO:0015620 ferric-enterobactin transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.053153 0 0.0917012 0 0 0.0327593 GO:0015623 iron-chelate-transporting ATPase activity molecular_function Escherichia Escherichia coli 0 0 0.139198 0 0 0 GO:0015628 protein secretion by the type II secretion system biological_process Coprothermobacter Coprothermobacter proteolyticus 12.0461 16.6253 20.4181 8.68141 8.19072 6.27339 GO:0015628 protein secretion by the type II secretion system biological_process Escherichia Escherichia coli 0.239371 0 0.111187 0 0 0 GO:0015643 toxic substance binding molecular_function Escherichia Escherichia coli 0.107934 0 0.406363 0 0 0 GO:0015648 lipid-linked peptidoglycan transporter activity molecular_function Escherichia Escherichia coli 0.0443792 0 0 0 0 0 GO:0015655 alanine:sodium symporter activity molecular_function Escherichia Escherichia coli 0.0759016 0 0.139018 0 0 0 GO:0015658 branched-chain amino acid transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 19.4622 2.06521 1.51941 1.18974 1.11601 0.516032 GO:0015661 L-lysine efflux transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.129711 0 0 0 0 0 GO:0015675 nickel cation transport biological_process Escherichia Escherichia coli 0.0341229 0 0 0 0 0 GO:0015682 ferric iron transport biological_process Escherichia Escherichia coli 0.0223597 0 0 0 0 0 GO:0015684 ferrous iron transport biological_process Escherichia Escherichia coli 0.329004 0 0.0804246 0 0 0 GO:0015685 ferric-enterobactin transport biological_process Escherichia Escherichia coli 0.053153 0 0.0917012 0 0 0.0327593 GO:0015692 lead ion transport biological_process Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0015693 magnesium ion transport biological_process Clostridium Clostridium thermocellum 1.51708 7.00716 5.29025 20.5804 20.1047 21.6624 GO:0015693 magnesium ion transport biological_process Coprothermobacter Coprothermobacter proteolyticus 1.24621 1.08189 1.3757 1.00187 0.476835 0.789716 GO:0015693 magnesium ion transport biological_process Escherichia Escherichia coli 0.691134 0 0 0 0 0.101479 GO:0015700 arsenite transport biological_process Escherichia Escherichia coli 0 0 0.0395583 0 0 0.185755 GO:0015707 nitrite transport biological_process Escherichia Escherichia coli 0.143588 0 0 0 0 0 GO:0015716 organic phosphonate transport biological_process Escherichia Escherichia coli 0 0 0 0 0 0.112281 GO:0015724 formate transport biological_process Escherichia Escherichia coli 0.139019 0 0 0 0 0 GO:0015726 L-idonate transport biological_process Escherichia Escherichia coli 0.145363 0 0 0 0 0.0552672 GO:0015734 taurine transport biological_process Escherichia Escherichia coli 0 0 0.111097 0 0 0 GO:0015739 sialic acid transport biological_process Escherichia Escherichia coli 0.0194189 0 0 0 0 0.103387 GO:0015747 urate transport biological_process Escherichia Escherichia coli 0.0374282 0 0.0694638 0 0 0 GO:0015749 monosaccharide transport biological_process Coprothermobacter Coprothermobacter proteolyticus 13.4668 15.9374 18.6096 2.48895 4.0153 5.36667 GO:0015749 monosaccharide transport biological_process Escherichia Escherichia coli 0.245981 0 0.113984 0 0 0.174565 GO:0015751 arabinose transport biological_process Escherichia Escherichia coli 0.0410252 0 0 0 0 0.0554289 GO:0015753 D-xylose transport biological_process Escherichia Escherichia coli 0.115323 0 0 0 0 0 GO:0015756 fucose transport biological_process Escherichia Escherichia coli 0.0410252 0 0 0 0 0.0554289 GO:0015757 galactose transport biological_process Escherichia Escherichia coli 0.333597 0 0.109022 0 0 0.0554289 GO:0015765 methylgalactoside transport biological_process Escherichia Escherichia coli 0.142252 0 0.0880025 0 0 0.212208 GO:0015769 melibiose transport biological_process Escherichia Escherichia coli 0.142252 0 0.0880025 0 0 0.212208 GO:0015771 trehalose transport biological_process Escherichia Escherichia coli 0.0383275 0 0 0 0 0.0431401 GO:0015793 glycerol transport biological_process Escherichia Escherichia coli 0.0724747 0 0 0 0 0 GO:0015794 glycerol-3-phosphate transport biological_process Clostridium Clostridium thermocellum 115.851 297.81 235.253 1285.84 1089.39 861.139 GO:0015794 glycerol-3-phosphate transport biological_process Coprothermobacter Coprothermobacter proteolyticus 188.38 65.4715 118.616 36.1918 34.5571 42.4546 GO:0015794 glycerol-3-phosphate transport biological_process Escherichia Escherichia coli 0.114108 0 0 0 0 0 GO:0015803 branched-chain amino acid transport biological_process Escherichia Escherichia coli 0.145411 0 0 0 0 0 GO:0015807 L-amino acid transport biological_process Escherichia Escherichia coli 0.707175 0 0.523098 0 0 0.179351 GO:0015809 arginine transport biological_process Escherichia Escherichia coli 0.0835087 0 0.154985 0 0 0 GO:0015814 p-aminobenzoyl-glutamate transport biological_process Escherichia Escherichia coli 0.0773355 0 0 0 0 0 GO:0015818 isoleucine transport biological_process Escherichia Escherichia coli 0.145411 0 0 0 0 0 GO:0015820 leucine transport biological_process Escherichia Escherichia coli 0.246832 0 0 0 0 0 GO:0015823 phenylalanine transport biological_process Escherichia Escherichia coli 0 0 0.0920621 0 0 0.105328 GO:0015829 valine transport biological_process Escherichia Escherichia coli 0.26941 0 0 0 0 0 GO:0015833 peptide transport biological_process Clostridium Clostridium thermocellum 1.79733 15.142 8.86768 34.1038 41.3 34.1558 GO:0015833 peptide transport biological_process Coprothermobacter Coprothermobacter proteolyticus 488.778 153.393 213.126 105.328 128.007 101.995 GO:0015833 peptide transport biological_process Escherichia Escherichia coli 0.674146 0 0.659049 0 0 0.279279 GO:0015846 polyamine transport biological_process Clostridium Clostridium thermocellum 2.86812 14.2759 7.34115 83.8084 72.8267 32.8495 GO:0015846 polyamine transport biological_process Escherichia Escherichia coli 0 0 0.181102 0 0 0 GO:0015847 putrescine transport biological_process Escherichia Escherichia coli 0.0392997 0 0 0 0 0.0918424 GO:0015851 nucleobase transport biological_process Escherichia Escherichia coli 0.186874 0 0 0 0 0 GO:0015853 adenine transport biological_process Escherichia Escherichia coli 0.123489 0 0.151873 0 0 0.054588 GO:0015857 uracil transport biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0548468 GO:0015860 purine nucleoside transmembrane transport biological_process Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015861 cytidine transport biological_process Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015862 uridine transport biological_process Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015864 pyrimidine nucleoside transport biological_process Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0015871 choline transport biological_process Escherichia Escherichia coli 0.265619 0 0 0 0 0 GO:0015886 heme transport biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0756407 GO:0015887 pantothenate transmembrane transport biological_process Escherichia Escherichia coli 0.111993 0 0 0 0 0 GO:0015889 cobalamin transport biological_process Escherichia Escherichia coli 0.0426293 0 0 0 0 0 GO:0015891 siderophore transport biological_process Escherichia Escherichia coli 0.111726 0 0.135725 0 0 0.0669738 GO:0015906 sulfathiazole transport biological_process Escherichia Escherichia coli 0.0266372 0 0.0494366 0 0 0 GO:0015914 phospholipid transport biological_process Escherichia Escherichia coli 0.110462 0 0 0 0 0 GO:0015920 lipopolysaccharide transport biological_process Escherichia Escherichia coli 0.098796 0 0.497839 0 0 0 GO:0015926 glucosidase activity molecular_function Clostridium Clostridium thermocellum 1.0845 6.84132 6.44917 14.4016 15.454 20.6395 GO:0015926 glucosidase activity molecular_function Escherichia Escherichia coli 0 0 0.0204783 0 0 0 GO:0015936 coenzyme A metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0465666 0.357427 0 0.0476512 0.12349 0.0309807 GO:0015937 coenzyme A biosynthetic process biological_process Clostridium Clostridium thermocellum 21.973 145.312 118.669 335.267 318.503 312.709 GO:0015937 coenzyme A biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 47.3424 81.1278 64.0564 61.3695 68.0343 58.0248 GO:0015937 coenzyme A biosynthetic process biological_process Escherichia Escherichia coli 0.125117 0 0.681377 0 0 0 GO:0015937 coenzyme A biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.144245 0.589068 0.603343 0.725884 0.123707 0.648653 GO:0015940 pantothenate biosynthetic process biological_process Clostridium Clostridium thermocellum 10.5444 43.7854 30.9204 93.2364 91.9091 101.826 GO:0015940 pantothenate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 86.372 51.1001 56.7059 49.8328 52.3983 44.7988 GO:0015940 pantothenate biosynthetic process biological_process Escherichia Escherichia coli 0.210084 0 0 0 0 0 GO:0015941 pantothenate catabolic process biological_process Clostridium Clostridium thermocellum 2.40399 14.0103 9.51189 35.0685 35.422 28.2307 GO:0015941 pantothenate catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 3.75624 4.16977 2.89714 3.77369 4.86838 3.58089 GO:0015941 pantothenate catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.144245 0.461509 0.356881 0.318537 0.0643926 0.383798 GO:0015948 methanogenesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 27.9748 18.0663 28.4618 27.1532 16.1025 27.568 GO:0015949 nucleobase-containing small molecule interconversion biological_process Escherichia Escherichia coli 0.153577 0 0 0 0 0 GO:0015969 guanosine tetraphosphate metabolic process biological_process Clostridium Clostridium thermocellum 2.39942 12.373 7.30416 35.2623 33.6013 30.5255 GO:0015969 guanosine tetraphosphate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.1728 7.58619 5.60298 8.45164 9.38304 7.76994 GO:0015970 guanosine tetraphosphate biosynthetic process biological_process Escherichia Escherichia coli 0.333403 0 0.0675693 0 0 0.0484437 GO:0015974 guanosine pentaphosphate catabolic process biological_process Escherichia Escherichia coli 0.254877 0 0.0675693 0 0 0.0484437 GO:0015976 carbon utilization biological_process Clostridium Clostridium thermocellum 0.658664 16.1959 9.70495 72.5495 65.9282 34.2944 GO:0015976 carbon utilization biological_process Escherichia Escherichia coli 0.208675 0 0.176005 0 0 0.270191 GO:0015977 carbon fixation biological_process Escherichia Escherichia coli 0.0194432 0 0 0 0 0.025483 GO:0015977 carbon fixation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0342444 0.262166 0 0.262877 0.15294 0.159528 GO:0015979 photosynthesis biological_process Clostridium Clostridium thermocellum 4.56945 22.8185 16.9742 52.6723 45.9177 66.2287 GO:0015979 photosynthesis biological_process Coprothermobacter Coprothermobacter proteolyticus 54.4072 55.9203 43.4377 63.3122 70.553 37.9243 GO:0015979 photosynthesis biological_process Escherichia Escherichia coli 0.585874 0 0.528331 0 0 0.0471824 GO:0015979 photosynthesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.87559 2.37592 2.75528 1.30118 0.823192 1.31645 GO:0015986 ATP synthesis coupled proton transport biological_process Clostridium Clostridium thermocellum 40.434 668.937 426.393 906.92 869.677 781.444 GO:0015986 ATP synthesis coupled proton transport biological_process Coprothermobacter Coprothermobacter proteolyticus 85.7719 70.0725 52.4691 100.01 132.568 71.7211 GO:0015986 ATP synthesis coupled proton transport biological_process Escherichia Escherichia coli 0 0 0.501177 0 0 0 GO:0015991 ATP hydrolysis coupled proton transport biological_process Clostridium Clostridium thermocellum 54.7493 782.906 507.51 1241.4 1193.76 1037.99 GO:0015991 ATP hydrolysis coupled proton transport biological_process Coprothermobacter Coprothermobacter proteolyticus 299.031 179.331 150.513 220.231 268.282 203.938 GO:0015991 ATP hydrolysis coupled proton transport biological_process Escherichia Escherichia coli 0.039421200000000003 0 0.501177 0 0 0 GO:0015991 ATP hydrolysis coupled proton transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.747471 0.443213 1.40799 1.46774 1.07041 1.40102 GO:0015992 proton transport biological_process Coprothermobacter Coprothermobacter proteolyticus 329.96 76.3616 128.399 27.1477 34.4745 46.8286 GO:0015992 proton transport biological_process Escherichia Escherichia coli 0.410666 0 0.222374 0 0 0.190702 GO:0015995 chlorophyll biosynthetic process biological_process Clostridium Clostridium thermocellum 2.47512 23.5746 18.4798 53.1256 45.2639 66.1155 GO:0015995 chlorophyll biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.989807 1.17071 0.813673 1.09185 0.833826 0.786255 GO:0015995 chlorophyll biosynthetic process biological_process Escherichia Escherichia coli 0.585874 0 0.528331 0 0 0.0471824 GO:0015995 chlorophyll biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.87559 2.37592 2.75528 1.30118 0.823192 1.31645 GO:0016024 CDP-diacylglycerol biosynthetic process biological_process Escherichia Escherichia coli 0.323463 0 0 0 0 0 GO:0016036 cellular response to phosphate starvation biological_process Escherichia Escherichia coli 0.190058 0 0 0 0 0 GO:0016048 detection of temperature stimulus biological_process Escherichia Escherichia coli 0.0815887 0 0 0 0 0 GO:0016051 carbohydrate biosynthetic process biological_process Clostridium Clostridium thermocellum 2.01823 7.02629 4.44239 48.2055 36.3285 39.9526 GO:0016051 carbohydrate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0453757 0.172926 0.0842136 0.742945 0.162121 0.332153 GO:0016052 carbohydrate catabolic process biological_process Clostridium Clostridium thermocellum 2.09353 22.1003 15.1099 60.3665 37.74 60.8098 GO:0016052 carbohydrate catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 91.1103 28.1964 28.6492 23.9455 28.6974 33.1018 GO:0016052 carbohydrate catabolic process biological_process Escherichia Escherichia coli 0.0771654 0 0 0 0 0 GO:0016052 carbohydrate catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.370175 0.347438 0.257738 0.142033 0.0826881 0.18514 GO:0016075 rRNA catabolic process biological_process Clostridium Clostridium thermocellum 1.29891 6.48698 2.88541 28.1773 22.2648 16.6507 GO:0016114 terpenoid biosynthetic process biological_process Clostridium Clostridium thermocellum 9.35047 70.1949 47.9649 168.702 161.307 170.131 GO:0016114 terpenoid biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 99.108 86.8614 64.7914 79.988 93.7285 68.1825 GO:0016114 terpenoid biosynthetic process biological_process Escherichia Escherichia coli 0.219709 0 0 0 0 0 GO:0016117 carotenoid biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.298381 0.635321 0.0921974 0.101719 0.133147 0.674751 GO:0016149 translation release factor activity, codon specific molecular_function Clostridium Clostridium thermocellum 8.22943 53.8034 38.0568 151.697 156.734 164.242 GO:0016149 translation release factor activity, codon specific molecular_function Coprothermobacter Coprothermobacter proteolyticus 100.411 68.8617 64.911 74.1595 79.4663 52.5343 GO:0016149 translation release factor activity, codon specific molecular_function Escherichia Escherichia coli 0.033734 0 0.0626527 0 0 0.0224432 GO:0016149 translation release factor activity, codon specific molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0452541 0.608344 0.251964 0.231566 0.242313 0.330859 GO:0016151 nickel cation binding molecular_function Clostridium Clostridium thermocellum 1.396 40.236 36.0393 83.4331 69.5957 62.1647 GO:0016151 nickel cation binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 78.4407 69.0492 74.2359 84.4078 80.3539 50.0137 GO:0016151 nickel cation binding molecular_function Escherichia Escherichia coli 0.253127 0 0 0 0 0 GO:0016151 nickel cation binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 15.4715 7.40832 19.0774 17.2368 11.5143 11.4617 GO:0016153 urocanate hydratase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 18.4303 10.6455 37.127 1.77538 2.92599 4.555 GO:0016154 pyrimidine-nucleoside phosphorylase activity molecular_function Clostridium Clostridium thermocellum 0.738284 1.98489 2.77977 9.99093 9.33907 7.15631 GO:0016154 pyrimidine-nucleoside phosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 30.5868 22.757 25.5162 24.0789 31.9322 18.0353 GO:0016154 pyrimidine-nucleoside phosphorylase activity molecular_function Escherichia Escherichia coli 0.0414384 0 0 0 0 0 GO:0016162 cellulose 1,4-beta-cellobiosidase activity molecular_function Clostridium Clostridium thermocellum 29.1765 25.9726 18.4872 104.811 91.8518 100.319 GO:0016163 nitrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.545869 1.22402 0.7655 2.16848 0.836213 1.44442 GO:0016197 endosomal transport biological_process Clostridium Clostridium thermocellum 0.844128 1.36483 0.989498 14.7573 12.6659 10.6787 GO:0016197 endosomal transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0151414 0.116311 0.168608 0.123953 0.0946464 0.362616 GO:0016208 AMP binding molecular_function Escherichia Escherichia coli 0.0624857 0 0 0 0 0 GO:0016208 AMP binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.321105 0.603863 0.128914 0.461639 0 0.431271 GO:0016209 antioxidant activity molecular_function Clostridium Clostridium thermocellum 6.81943 141.165 105.744 337.12 230.315 488.91 GO:0016209 antioxidant activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 47.8557 15.3999 95.7575 7.71615 13.4677 28.4274 GO:0016226 iron-sulfur cluster assembly biological_process Clostridium Clostridium thermocellum 3.46617 67.6044 65.482 114.777 110.089 136.593 GO:0016226 iron-sulfur cluster assembly biological_process Coprothermobacter Coprothermobacter proteolyticus 63.3322 62.2854 59.1862 6.35001 10.196 9.64194 GO:0016226 iron-sulfur cluster assembly biological_process Escherichia Escherichia coli 0.360016 0 0.157827 0 0 0.0375455 GO:0016226 iron-sulfur cluster assembly biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.381501 1.37897 0.790669 0.528142 0.400766 0.537408 GO:0016259 selenocysteine metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 33.2716 51.5545 66.8396 27.4989 35.3101 21.7446 GO:0016259 selenocysteine metabolic process biological_process Escherichia Escherichia coli 0.0286545 0 0 0 0 0 GO:0016260 selenocysteine biosynthetic process biological_process Clostridium Clostridium thermocellum 2.40476 16.8858 13.3064 39.3101 43.4919 37.9766 GO:0016260 selenocysteine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.9356 17.2239 16.0292 17.8264 20.1536 21.2747 GO:0016260 selenocysteine biosynthetic process biological_process Escherichia Escherichia coli 0.0212417 0 0 0 0 0 GO:0016298 lipase activity molecular_function Escherichia Escherichia coli 0.0364075 0 0 0 0 0 GO:0016301 kinase activity molecular_function Clostridium Clostridium thermocellum 45.5243 226.434 179.036 916.407 881.102 1045.35 GO:0016301 kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 515.008 453.921 527.034 323.433 389.687 304.637 GO:0016301 kinase activity molecular_function Escherichia Escherichia coli 2.76884 0 3.57161 0 0 0.494041 GO:0016301 kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 4.29557 4.98269 2.66773 3.33859 2.01507 2.95907 GO:0016310 phosphorylation biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0016310 phosphorylation biological_process Escherichia Escherichia coli 0.143904 0 0.567393 0 0 0 GO:0016310 phosphorylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0632878 0.187441 0.0587285 0.0645628 0.113029 0.215668 GO:0016311 dephosphorylation biological_process Clostridium Clostridium thermocellum 1.23491 9.13104 5.3175 27.0817 19.7135 23.0007 GO:0016311 dephosphorylation biological_process Coprothermobacter Coprothermobacter proteolyticus 9.94741 5.0141 2.59939 7.62938 7.53182 5.54085 GO:0016311 dephosphorylation biological_process Escherichia Escherichia coli 1.52656 0 0.779257 0 0 0.438612 GO:0016311 dephosphorylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.281003 0.744397 0.263782 0.502426 0.109621 0 GO:0016405 CoA-ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.294541 0.161957 0.702937 0.517149 0.187709 0.47619 GO:0016407 acetyltransferase activity molecular_function Escherichia Escherichia coli 0.0333938 0 0.0817327 0 0 0 GO:0016407 acetyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.039421200000000003 0 0 0 0.0704043 0.0524537 GO:0016410 N-acyltransferase activity molecular_function Escherichia Escherichia coli 0.118215 0 0 0 0 0 GO:0016413 O-acetyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.223276 0 0 0 GO:0016415 octanoyltransferase activity molecular_function Escherichia Escherichia coli 0.341083 0 0 0 0 0 GO:0016416 O-palmitoyltransferase activity molecular_function Escherichia Escherichia coli 0.118264 0 0 0 0 0 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.611927 4.37182 3.08121 10.9291 8.2845 15.2462 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.495997 0.158597 0.153407 0.169191 0 0 GO:0016430 tRNA (adenine-N6-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.140416 0 0 0 GO:0016434 rRNA (cytosine) methyltransferase activity molecular_function Escherichia Escherichia coli 0.129006 0 0 0 0 0 GO:0016437 tRNA cytidylyltransferase activity molecular_function Escherichia Escherichia coli 0.0223111 0 0 0 0 0 GO:0016437 tRNA cytidylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.15365 0.0742451 0.0614043 0.0178615 0 GO:0016462 pyrophosphatase activity molecular_function Clostridium Clostridium thermocellum 3.92593 27.1335 16.1024 89.4446 80.4397 68.3222 GO:0016462 pyrophosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 51.7973 29.7592 26.6445 20.2701 25.1246 15.1858 GO:0016462 pyrophosphatase activity molecular_function Escherichia Escherichia coli 0.03405 0 0 0 0 0 GO:0016462 pyrophosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.122249 0.356213 0.286922 0.126564 0.193243 0.575956 GO:0016463 zinc-exporting ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.8413 1.36716 1.77033 2.1443 2.67512 1.34029 GO:0016463 zinc-exporting ATPase activity molecular_function Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0016485 protein processing biological_process Escherichia Escherichia coli 0.169424 0 0 0 0 0 GO:0016491 oxidoreductase activity molecular_function Clostridium Clostridium thermocellum 84.3911 839.947 654.431 2048.18 1791.14 2380.9 GO:0016491 oxidoreductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6523.31 14984.4 13383.7 5555.74 6228.2 7900.53 GO:0016491 oxidoreductase activity molecular_function Escherichia Escherichia coli 2.47551 0 2.55451 0 0 1.25067 GO:0016491 oxidoreductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 5.66571 16.9487 11.6479 17.644 7.50235 15.0906 GO:0016539 intein-mediated protein splicing biological_process Clostridium Clostridium thermocellum 15.9503 80.7575 104.534 135.659 145.23 149.925 GO:0016539 intein-mediated protein splicing biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.2401 0.477658 0.379705 0.351489 0.309136 0.585237 GO:0016540 protein autoprocessing biological_process Escherichia Escherichia coli 0.0596421 0 0.0552553 0 0 0 GO:0016597 amino acid binding molecular_function Clostridium Clostridium thermocellum 30.9154 201.901 156.513 513.895 466.456 471.19 GO:0016597 amino acid binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 64.8263 25.8324 29.2434 29.6508 33.8493 23.0321 GO:0016597 amino acid binding molecular_function Escherichia Escherichia coli 0.744069 0 0.204467 0 0 0 GO:0016597 amino acid binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.46143 2.34862 2.72848 2.31188 1.65945 3.41712 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors molecular_function Clostridium Clostridium thermocellum 0.590661 6.23938 6.73266 15.5823 17.5142 24.8387 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors molecular_function Coprothermobacter Coprothermobacter proteolyticus 49.4772 24.604 18.3525 18.578 18.8433 15.6221 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors molecular_function Escherichia Escherichia coli 0.410034 0 0.246732 0 0 0.0495755 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0946886 0.363914 0.131891 0.0242484 0.042299 0.0945589 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function Clostridium Clostridium thermocellum 12.3699 143.819 94.7709 392.804 338.032 274.143 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 111.98 113.11 90.9395 125.413 149.457 106.639 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 2.46764 0 2.04233 0 0 0.170588 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.242554 0.465803 0.540013 0.198563 0.216508 0.516129 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 0.0302342 0 0.112225 0 0 0 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 160.445 10.9993 20.7678 5.23805 5.2151 4.77089 GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor molecular_function Clostridium Clostridium thermocellum 5.21115 122.998 88.8388 212.784 207.427 225.863 GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 440.06 99.0689 205.948 63.8164 73.35 55.8581 GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor molecular_function Escherichia Escherichia coli 0.0653293 0 0.146596 0 0 0 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors molecular_function Escherichia Escherichia coli 0.0368206 0 0 0 0 0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor molecular_function Clostridium Clostridium thermocellum 0.352822 1.59544 1.4264 9.34948 6.41586 5.38808 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 0.130999 0 0.0405055 0 0 0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.453951 1.49108 0.952646 1.67878 1.15991 2.00246 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 0.0566527 0 0.113894 0 0 0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123051 0.425617 0.274202 0.100799 0.109795 0.294898 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors molecular_function Escherichia Escherichia coli 0.0261755 0 0 0 0 0 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.309196 0.166391 0.522873 0.201 0.2735 0.238855 GO:0016651 oxidoreductase activity, acting on NAD(P)H molecular_function Clostridium Clostridium thermocellum 0.783927 6.16806 3.72998 19.1628 18.519 16.1259 GO:0016651 oxidoreductase activity, acting on NAD(P)H molecular_function Coprothermobacter Coprothermobacter proteolyticus 111.537 75.7659 81.9169 105.601 102.045 51.835 GO:0016651 oxidoreductase activity, acting on NAD(P)H molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123683 0.778142 0.427653 0.10331 0.320248 0.0924892 GO:0016652 oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0532988 0.511776 0 0.10908 0.285567 0.0709192 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.156229 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0532988 0.511776 0 0.10908 0.285567 0.0709192 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors molecular_function Escherichia Escherichia coli 0.0564826 0 0 0 0 0 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor molecular_function Escherichia Escherichia coli 0.0206584 0 0 0 0 0 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor molecular_function Escherichia Escherichia coli 0.0685131 0 0 0 0 0 GO:0016682 oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor molecular_function Escherichia Escherichia coli 0.0920638 0 0.0646374 0 0 0.023187 GO:0016692 NADH peroxidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 56.6641 72.7031 100.891 75.3205 108.043 91.2171 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function Escherichia Escherichia coli 0.0551702 0 0 0 0 0 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 6.22434 1.48707 6.3337 6.22444 5.29137 12.8244 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors molecular_function Escherichia Escherichia coli 0.0500177 0 0 0 0 0 GO:0016708 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor molecular_function Escherichia Escherichia coli 0.0498476 0 0 0 0 0 GO:0016722 oxidoreductase activity, oxidizing metal ions molecular_function Escherichia Escherichia coli 0.068659 0 0 0 0 0 GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor molecular_function Clostridium Clostridium thermocellum 4.06544 9.76006 8.49578 22.5395 26.214 33.86 GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 0.0723289 0 0 0 0 0 GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.361571 0.694877 0.805193 0.923204 0.290624 0.673651 GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.610117 0.416738 0.650205 0.283701 0.422055 GO:0016740 transferase activity molecular_function Clostridium Clostridium thermocellum 48.9152 387.626 291.329 984.594 869.141 909.554 GO:0016740 transferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1378.86 757.897 842.507 602.021 687.286 590.54 GO:0016740 transferase activity molecular_function Escherichia Escherichia coli 1.42774 0 0.600772 0 0 0.310518 GO:0016740 transferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.08045 4.35082 4.08415 6.98756 1.99817 4.74661 GO:0016741 transferase activity, transferring one-carbon groups molecular_function Escherichia Escherichia coli 0.0964628 0 0 0 0 0 GO:0016742 hydroxymethyl-, formyl- and related transferase activity molecular_function Escherichia Escherichia coli 0.0265157 0 0.049211 0 0 0 GO:0016743 carboxyl- or carbamoyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.241607 3.27014 1.08914 9.48984 7.39755 8.80261 GO:0016743 carboxyl- or carbamoyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 5.79985 8.39756 4.91912 6.8849 7.22312 7.9444 GO:0016743 carboxyl- or carbamoyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.0214706 0 0 0 GO:0016743 carboxyl- or carbamoyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0714782 0.343191 0.442223 0.231615 0.0850971 0.110825 GO:0016744 transferase activity, transferring aldehyde or ketonic groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.149324 0.501741 0.346552 0.076401 0.266447 0.347061 GO:0016746 transferase activity, transferring acyl groups molecular_function Clostridium Clostridium thermocellum 1.00884 3.38855 2.91915 17.8118 14.5481 21.1241 GO:0016746 transferase activity, transferring acyl groups molecular_function Coprothermobacter Coprothermobacter proteolyticus 44.8414 32.6972 30.944 32.8257 38.1974 28.2954 GO:0016746 transferase activity, transferring acyl groups molecular_function Escherichia Escherichia coli 0.368522 0 0 0 0 0.0961435 GO:0016746 transferase activity, transferring acyl groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.134733 0.631801 0.129762 0 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function Clostridium Clostridium thermocellum 8.12898 55.4573 22.4483 204.23 158.909 103.123 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function Coprothermobacter Coprothermobacter proteolyticus 80.7218 94.8999 70.5393 108.616 128.233 96.9585 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function Escherichia Escherichia coli 0.305794 0 0 0 0 0 GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.394625 1.23685 0.427383 1.03619 0.517636 1.3117 GO:0016755 transferase activity, transferring amino-acyl groups molecular_function Clostridium Clostridium thermocellum 0.187093 2.10419 0.942452 5.19669 4.29486 4.19435 GO:0016755 transferase activity, transferring amino-acyl groups molecular_function Escherichia Escherichia coli 0.0143151 0 0 0 0 0 GO:0016757 transferase activity, transferring glycosyl groups molecular_function Clostridium Clostridium thermocellum 8.12543 85.9673 76.0786 173.097 167.105 176.538 GO:0016757 transferase activity, transferring glycosyl groups molecular_function Coprothermobacter Coprothermobacter proteolyticus 38.861 37.6813 31.4745 33.9496 44.5723 36.2736 GO:0016757 transferase activity, transferring glycosyl groups molecular_function Escherichia Escherichia coli 1.04247 0 0.476955 0 0 0.281833 GO:0016757 transferase activity, transferring glycosyl groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0867898 0.192855 0.17596 0.823002 0.352586 0.372447 GO:0016758 transferase activity, transferring hexosyl groups molecular_function Clostridium Clostridium thermocellum 2.523 26.836 20.7677 45.9819 45.7431 48.9789 GO:0016758 transferase activity, transferring hexosyl groups molecular_function Coprothermobacter Coprothermobacter proteolyticus 23.0057 10.0247 7.60845 14.6403 15.6966 16.805 GO:0016758 transferase activity, transferring hexosyl groups molecular_function Escherichia Escherichia coli 0.0411225 0 0.11448 0 0 0 GO:0016758 transferase activity, transferring hexosyl groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0861093 0 0 0 0 0 GO:0016760 cellulose synthase (UDP-forming) activity molecular_function Escherichia Escherichia coli 0.0393726 0 0 0 0 0 GO:0016763 transferase activity, transferring pentosyl groups molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.93853 1.14346 1.69027 0.728719 1.27641 0.422896 GO:0016763 transferase activity, transferring pentosyl groups molecular_function Escherichia Escherichia coli 0.200095 0 0.0586834 0 0 0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups molecular_function Clostridium Clostridium thermocellum 5.18554 58.2138 51.3871 116.81 117.896 126.646 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.46276 2.28943 2.91662 0.637297 0.99204 1.80244 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.391125 0.370962 0.488908 0.55622 0.130803 0.110567 GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function Escherichia Escherichia coli 0 0 0.287237 0 0 0.103032 GO:0016772 transferase activity, transferring phosphorus-containing groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.187441 0 0 0 0.131458 GO:0016773 phosphotransferase activity, alcohol group as acceptor molecular_function Clostridium Clostridium thermocellum 3.28428 20.1069 21.7966 37.1672 36.8788 48.0418 GO:0016773 phosphotransferase activity, alcohol group as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.1265 24.3598 14.7753 15.3747 16.4329 16.4033 GO:0016773 phosphotransferase activity, alcohol group as acceptor molecular_function Escherichia Escherichia coli 0.618927 0 0.645201 0 0 0.0419435 GO:0016773 phosphotransferase activity, alcohol group as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.121071 0.350792 0.193539 0.084446 0.0419435 GO:0016774 phosphotransferase activity, carboxyl group as acceptor molecular_function Escherichia Escherichia coli 0.0195648 0 0 0 0 0.0390654 GO:0016774 phosphotransferase activity, carboxyl group as acceptor molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0945671 0.120978 0.117006 0.61285 0 0.209718 GO:0016775 phosphotransferase activity, nitrogenous group as acceptor molecular_function Clostridium Clostridium thermocellum 6.59697 103.14 172.408 53.3925 61.8042 46.4737 GO:0016776 phosphotransferase activity, phosphate group as acceptor molecular_function Escherichia Escherichia coli 0.0975565 0 0 0 0 0 GO:0016779 nucleotidyltransferase activity molecular_function Clostridium Clostridium thermocellum 14.4557 146.815 108.905 386.373 341.151 378.763 GO:0016779 nucleotidyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 106.424 100.867 102.97 72.0581 93.4425 81.5766 GO:0016779 nucleotidyltransferase activity molecular_function Escherichia Escherichia coli 0.160966 0 0.298739 0 0 0 GO:0016779 nucleotidyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.45973 2.86805 0.948767 1.18951 0.561324 2.79457 GO:0016780 phosphotransferase activity, for other substituted phosphate groups molecular_function Escherichia Escherichia coli 0.28917 0 0.14619 0 0 0 GO:0016780 phosphotransferase activity, for other substituted phosphate groups molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.121071 0.45377 0.534235 0.431063 0.411124 GO:0016783 sulfurtransferase activity molecular_function Clostridium Clostridium thermocellum 3.79967 38.8015 41.6555 95.6325 84.0832 62.1276 GO:0016783 sulfurtransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 47.4728 25.5698 16.3938 7.78537 10.9886 7.01621 GO:0016783 sulfurtransferase activity molecular_function Escherichia Escherichia coli 0.205102 0 0 0 0 0 GO:0016783 sulfurtransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0814186 0.312713 1.0964 0.722328 0.209238 1.2736 GO:0016787 hydrolase activity molecular_function Clostridium Clostridium thermocellum 160.454 821.53 712.615 2056.03 1971.88 2453.43 GO:0016787 hydrolase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 834.065 641.316 665.284 526.99 629.442 544.747 GO:0016787 hydrolase activity molecular_function Escherichia Escherichia coli 1.50445 0 0.276773 0 0 0.343051 GO:0016787 hydrolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.39004 6.54135 3.11978 3.57418 2.73298 5.2576599999999996 GO:0016788 hydrolase activity, acting on ester bonds molecular_function Clostridium Clostridium thermocellum 24.1927 112.856 133.745 239.459 240.616 272.626 GO:0016788 hydrolase activity, acting on ester bonds molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.6673 15.5307 13.405 14.5746 16.6134 19.4505 GO:0016788 hydrolase activity, acting on ester bonds molecular_function Escherichia Escherichia coli 0.359263 0 0.0618859 0 0 0 GO:0016788 hydrolase activity, acting on ester bonds molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.11366 2.4331 3.92376 3.21026 0.962481 1.75975 GO:0016790 thiolester hydrolase activity molecular_function Clostridium Clostridium thermocellum 0.635138 3.35602 4.71429 6.21626 8.14849 13.8948 GO:0016790 thiolester hydrolase activity molecular_function Escherichia Escherichia coli 0.381719 0 0.335681 0 0 0 GO:0016791 phosphatase activity molecular_function Clostridium Clostridium thermocellum 1.85348 10.1261 8.60101 22.7806 24.3596 18.8439 GO:0016791 phosphatase activity molecular_function Escherichia Escherichia coli 1.12968 0 0.270367 0 0 0.0419435 GO:0016795 phosphoric triester hydrolase activity molecular_function Escherichia Escherichia coli 0.0461291 0 0.0378893 0 0 0 GO:0016798 hydrolase activity, acting on glycosyl bonds molecular_function Clostridium Clostridium thermocellum 13.361 27.8183 15.0313 55.0456 56.3294 81.1271 GO:0016798 hydrolase activity, acting on glycosyl bonds molecular_function Coprothermobacter Coprothermobacter proteolyticus 99.2343 61.2982 62.9423 43.6585 69.2681 59.5412 GO:0016798 hydrolase activity, acting on glycosyl bonds molecular_function Escherichia Escherichia coli 0.288076 0 0.435367 0 0 0.175277 GO:0016805 dipeptidase activity molecular_function Clostridium Clostridium thermocellum 0.309172 1.84039 0.688639 4.5854799999999996 4.02984 5.22299 GO:0016805 dipeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.9339 18.7187 13.0648 22.0688 19.0866 15.9968 GO:0016805 dipeptidase activity molecular_function Escherichia Escherichia coli 0.0461291 0 0.0378893 0 0 0 GO:0016807 cysteine-type carboxypeptidase activity molecular_function Escherichia Escherichia coli 0.0143151 0 0 0 0 0 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function Clostridium Clostridium thermocellum 41.9027 75.2149 73.5632 156.028 132.134 159.755 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function Coprothermobacter Coprothermobacter proteolyticus 258.911 224.072 204.845 214.696 259.126 236.585 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function Escherichia Escherichia coli 0.283312 0 0.29274 0 0 0.101221 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.212393 0.593082 0.134733 0.774232 0.441719 0.465971 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function Coprothermobacter Coprothermobacter proteolyticus 23.564 5.88078 5.84105 6.14106 7.45656 5.88991 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0872827 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.261074 0.588694 0.812726 0.357931 0.0390435 0.174792 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides molecular_function Escherichia Escherichia coli 0.0786479 0 0 0 0 0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines molecular_function Coprothermobacter Coprothermobacter proteolyticus 31.334 20.0835 26.696 23.9334 29.1499 17.6021 GO:0016817 hydrolase activity, acting on acid anhydrides molecular_function Escherichia Escherichia coli 0.123538 0 0 0 0 0 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular_function Escherichia Escherichia coli 0.127402 0 0 0 0 0.151831 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances molecular_function Escherichia Escherichia coli 0.0180336 0 0 0 0 0 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.498476 0.104082 0.292921 0.744661 0.0469868 0.557296 GO:0016829 lyase activity molecular_function Clostridium Clostridium thermocellum 43.1951 251.02 228.725 643.928 620.508 599.84 GO:0016829 lyase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 170.495 91.7257 80.737 122.151 151.113 102.012 GO:0016829 lyase activity molecular_function Escherichia Escherichia coli 0.208626 0 0.0458281 0 0 0 GO:0016829 lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.7801 5.12952 3.69335 3.16062 1.6869 2.46513 GO:0016831 carboxy-lyase activity molecular_function Escherichia Escherichia coli 0.113014 0 0 0 0 0 GO:0016831 carboxy-lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.173288 0.290917 0.321247 0.177324 0.0580336 0.0576602 GO:0016832 aldehyde-lyase activity molecular_function Clostridium Clostridium thermocellum 4.18625 33.5688 32.7505 51.4121 45.198 55.465 GO:0016832 aldehyde-lyase activity molecular_function Escherichia Escherichia coli 0 0 0.467166 0 0 0 GO:0016833 oxo-acid-lyase activity molecular_function Escherichia Escherichia coli 0.0401017 0 0.148851 0 0 0 GO:0016833 oxo-acid-lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.121538 0.352236 0.19431 0.0565144 0.252599 GO:0016835 carbon-oxygen lyase activity molecular_function Escherichia Escherichia coli 0.065062 0 0 0 0 0 GO:0016836 hydro-lyase activity molecular_function Clostridium Clostridium thermocellum 10.7124 94.1762 47.619 230.162 116.762 364.765 GO:0016836 hydro-lyase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.5226 16.506 11.0525 16.5646 19.4523 14.2968 GO:0016836 hydro-lyase activity molecular_function Escherichia Escherichia coli 0.14981 0 0 0 0 0 GO:0016836 hydro-lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.642478 2.32827 1.93741 1.91555 1.04089 1.80335 GO:0016837 carbon-oxygen lyase activity, acting on polysaccharides molecular_function Escherichia Escherichia coli 0.55124 0 0 0 0 0.0656156 GO:0016840 carbon-nitrogen lyase activity molecular_function Clostridium Clostridium thermocellum 2.86788 11.0986 10.9256 39.106 36.1662 33.0985 GO:0016840 carbon-nitrogen lyase activity molecular_function Escherichia Escherichia coli 0.0464694 0 0 0 0 0.12389 GO:0016840 carbon-nitrogen lyase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.127159 0.487086 0.236087 0.994084 0.198647 0.549632 GO:0016851 magnesium chelatase activity molecular_function Clostridium Clostridium thermocellum 2.23945 17.4025 12.2372 39.5776 34.6634 54.8841 GO:0016851 magnesium chelatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.989807 1.17071 0.813673 1.09185 0.833826 0.786255 GO:0016851 magnesium chelatase activity molecular_function Escherichia Escherichia coli 0.585874 0 0.528331 0 0 0.0471824 GO:0016851 magnesium chelatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.87559 2.37592 2.75528 1.30118 0.85733 1.36729 GO:0016852 sirohydrochlorin cobaltochelatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.196916 0.379841 0.419758 0.457866 1.36338 GO:0016853 isomerase activity molecular_function Clostridium Clostridium thermocellum 13.9559 63.2049 53.7063 163.665 157.755 206.418 GO:0016853 isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 145.812 229.964 301.385 169.261 201.171 138.079 GO:0016853 isomerase activity molecular_function Escherichia Escherichia coli 0.324411 0 0.119802 0 0 0 GO:0016853 isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.41757 3.25226 2.36899 4.12133 1.97479 3.57688 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives molecular_function Escherichia Escherichia coli 0.0595692 0 0 0 0 0 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives molecular_function Clostridium Clostridium thermocellum 5.98225 36.2569 27.1105 100.723 88.9785 89.6585 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives molecular_function Escherichia Escherichia coli 0.071381 0 0.0471361 0 0 0.0951734 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0682701 0.087373 0.168878 0.0465817 0 0.121109 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.6022 8.82271 4.81488 8.87252 10.4749 8.15105 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses molecular_function Escherichia Escherichia coli 0.336174 0 0 0 0 0 GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups molecular_function Clostridium Clostridium thermocellum 3.3367 20.9109 5.65737 28.5364 43.3716 65.2845 GO:0016868 intramolecular transferase activity, phosphotransferases molecular_function Clostridium Clostridium thermocellum 0.0630447 0.363214 0.234012 1.16099 0.787924 1.00658 GO:0016868 intramolecular transferase activity, phosphotransferases molecular_function Coprothermobacter Coprothermobacter proteolyticus 23.5838 15.8669 9.26421 28.7642 30.7572 21.7891 GO:0016868 intramolecular transferase activity, phosphotransferases molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.228968 0.281535 0.153813 0 0.0373941 0 GO:0016869 intramolecular transferase activity, transferring amino groups molecular_function Escherichia Escherichia coli 0.027658 0 0 0 0 0 GO:0016872 intramolecular lyase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.691985 1.13095 2.00534 0.404388 0.791896 0.524763 GO:0016872 intramolecular lyase activity molecular_function Escherichia Escherichia coli 0.0900222 0 0 0 0 0 GO:0016874 ligase activity molecular_function Clostridium Clostridium thermocellum 12.658 55.6299 42.6905 168.182 143.736 102.032 GO:0016874 ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 179.082 140.979 174.861 112.425 124.84 93.3947 GO:0016874 ligase activity molecular_function Escherichia Escherichia coli 0.549077 0 0.627565 0 0 0.119363 GO:0016874 ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.678156 0.936366 1.15405 0.786344 0.654886 0.852453 GO:0016878 acid-thiol ligase activity molecular_function Escherichia Escherichia coli 0.069704 0 0.0642766 0 0 0 GO:0016879 ligase activity, forming carbon-nitrogen bonds molecular_function Clostridium Clostridium thermocellum 3.23407 21.9685 15.6691 74.2925 67.1286 68.034 GO:0016879 ligase activity, forming carbon-nitrogen bonds molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.9417 9.21365 4.19593 3.90655 4.23014 3.57849 GO:0016879 ligase activity, forming carbon-nitrogen bonds molecular_function Escherichia Escherichia coli 0.178051 0 0.0787106 0 0 0 GO:0016879 ligase activity, forming carbon-nitrogen bonds molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.20631 1.89798 2.29411 0.996993 0.777333 2.23452 GO:0016881 acid-amino acid ligase activity molecular_function Clostridium Clostridium thermocellum 1.57886 8.27644 7.72167 23.5333 21.6319 23.9263 GO:0016881 acid-amino acid ligase activity molecular_function Escherichia Escherichia coli 0.0397128 0 0.0737038 0 0 0 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor molecular_function Clostridium Clostridium thermocellum 69.1656 494.745 265.457 1228.89 1051.44 1149.61 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor molecular_function Coprothermobacter Coprothermobacter proteolyticus 12.7622 20.7861 18.2133 17.6636 24.1738 13.057 GO:0016887 ATPase activity molecular_function Clostridium Clostridium thermocellum 120.268 683.451 505.781 1920.06 1561.26 1613.93 GO:0016887 ATPase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1114.05 637.734 789.1 515.807 630.094 456.637 GO:0016887 ATPase activity molecular_function Escherichia Escherichia coli 1.60183 0 0.975019 0 0 0.786352 GO:0016887 ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.15995 6.1794 5.13297 4.15229 2.49748 4.77539 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters molecular_function Clostridium Clostridium thermocellum 1.72782 10.1905 6.13095 35.7433 29.6849 20.023 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters molecular_function Coprothermobacter Coprothermobacter proteolyticus 23.7802 10.2669 11.4827 9.10722 10.74 9.14537 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters molecular_function Escherichia Escherichia coli 0.0768008 0 0.142536 0 0 0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.827796 0.530586 0.72531 1.20108 0.612565 0.522758 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor molecular_function Escherichia Escherichia coli 0.0155303 0 0 0 0 0 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors molecular_function Clostridium Clostridium thermocellum 12.8185 56.9574 36.3573 162.379 129.516 111.612 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.4209 4.47964 7.20398 4.03809 4.54913 2.72074 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors molecular_function Escherichia Escherichia coli 0.0258109 0 0 0 0 0.0119007 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.288392 0.486852 0.199596 0.0387477 0.0336829 0 GO:0016920 pyroglutamyl-peptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 40.8456 71.071 59.7194 78.6609 88.171 67.0996 GO:0016966 nitric oxide reductase activity molecular_function Escherichia Escherichia coli 0.0447681 0 0.124584 0 0 0 GO:0016985 mannan endo-1,4-beta-mannosidase activity molecular_function Clostridium Clostridium thermocellum 41.2293 46.4253 52.9957 128.966 117.098 135.834 GO:0016987 sigma factor activity molecular_function Clostridium Clostridium thermocellum 64.1625 339.573 262.041 939.367 878.372 972.412 GO:0016987 sigma factor activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 170.255 122.214 124.81 81.1139 113.434 92.5824 GO:0016987 sigma factor activity molecular_function Escherichia Escherichia coli 0.536974 0 0.215338 0 0 0.0917454 GO:0016987 sigma factor activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.342298 0.657351 1.91549 1.08847 0 0.231191 GO:0016989 sigma factor antagonist activity molecular_function Clostridium Clostridium thermocellum 0 1.24413 1.65441 4.88044 4.12021 4.4064 GO:0016989 sigma factor antagonist activity molecular_function Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:0016992 lipoate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 33.0985 42.7352 36.02 30.6123 37.2339 39.0065 GO:0016992 lipoate synthase activity molecular_function Escherichia Escherichia coli 0.0893174 0 0 0 0 0 GO:0016993 precorrin-8X methylmutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.206512 0 0.0957608 0.158398 0.276473 0.0686555 GO:0016994 precorrin-6A reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.35634 0.393172 0.171605 0.340787 GO:0016998 cell wall macromolecule catabolic process biological_process Escherichia Escherichia coli 0.439126 0 0 0 0 0.0966933 GO:0017001 antibiotic catabolic process biological_process Escherichia Escherichia coli 0.073617 0 0 0 0 0 GO:0017004 cytochrome complex assembly biological_process Clostridium Clostridium thermocellum 7.81876 83.5873 67.8413 138.875 101.384 229.216 GO:0017004 cytochrome complex assembly biological_process Escherichia Escherichia coli 0.381671 0 0.192785 0 0 0 GO:0017004 cytochrome complex assembly biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0 0.147645 0 GO:0017013 protein flavinylation biological_process Clostridium Clostridium thermocellum 0.670865 14.7097 11.1055 32.1483 25.356 47.2252 GO:0017038 protein import biological_process Clostridium Clostridium thermocellum 1.53359 8.4545 6.70407 23.1515 21.6566 17.3492 GO:0017038 protein import biological_process Coprothermobacter Coprothermobacter proteolyticus 22.2381 15.0365 29.4212 14.101 18.5976 11.9837 GO:0017038 protein import biological_process Escherichia Escherichia coli 0.0846267 0 0.118404 0 0 0 GO:0017057 6-phosphogluconolactonase activity molecular_function Escherichia Escherichia coli 0 0 0.0532706 0 0 0 GO:0017061 S-methyl-5-thioadenosine phosphorylase activity molecular_function Clostridium Clostridium thermocellum 3.18101 9.1625 8.16429 42.2096 39.3841 31.042 GO:0017061 S-methyl-5-thioadenosine phosphorylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 53.6806 43.6106 43.2065 48.0188 47.6454 48.9161 GO:0017061 S-methyl-5-thioadenosine phosphorylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.259407 0.14355 0.062461 0.09333 GO:0017103 UTP:galactose-1-phosphate uridylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.59595 13.7924 5.45755 15.3531 18.278 12.0259 GO:0017108 5'-flap endonuclease activity molecular_function Escherichia Escherichia coli 0.103438 0 0 0 0 0 GO:0017108 5'-flap endonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.232128 0 0.32251 0.475343 0.103718 0.0772576 GO:0017111 nucleoside-triphosphatase activity molecular_function Clostridium Clostridium thermocellum 4.42378 27.4467 20.7349 59.5457 61.5965 71.5612 GO:0017111 nucleoside-triphosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.9694 79.6803 76.3232 58.9659 71.4159 58.7156 GO:0017111 nucleoside-triphosphatase activity molecular_function Escherichia Escherichia coli 0.0136346 0 0 0 0 0 GO:0017111 nucleoside-triphosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.556563 0.768948 1.08797 1.61763 0.995513 2.01636 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity molecular_function Escherichia Escherichia coli 0.110802 0 0 0 0 0.0384186 GO:0017148 negative regulation of translation biological_process Clostridium Clostridium thermocellum 1.39243 22.0746 15.9619 51.3402 47.5091 73.1241 GO:0017148 negative regulation of translation biological_process Coprothermobacter Coprothermobacter proteolyticus 4.65391 2.99453 3.27865 1.59564 2.6893 3.31622 GO:0017148 negative regulation of translation biological_process Escherichia Escherichia coli 0.964482 0 0 0 0 0 GO:0017150 tRNA dihydrouridine synthase activity molecular_function Clostridium Clostridium thermocellum 9.76146 48.7718 59.4041 84.9538 94.6885 113.978 GO:0017150 tRNA dihydrouridine synthase activity molecular_function Escherichia Escherichia coli 0.137853 0 0.42418 0 0 0.0364136 GO:0017150 tRNA dihydrouridine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.126211 0.161211 1.24633 0.128852 0.149924 0.167548 GO:0017153 sodium:dicarboxylate symporter activity molecular_function Escherichia Escherichia coli 0.170153 0 0.0387464 0 0 0 GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.139875 0 0 0.200404 GO:0018106 peptidyl-histidine phosphorylation biological_process Escherichia Escherichia coli 0.417033 0 0.500184 0 0 0.103032 GO:0018160 peptidyl-pyrromethane cofactor linkage biological_process Clostridium Clostridium thermocellum 0.233319 3.13586 4.32944 6.23263 4.85062 5.67706 GO:0018160 peptidyl-pyrromethane cofactor linkage biological_process Escherichia Escherichia coli 0.0613677 0 0.0569693 0 0 0 GO:0018160 peptidyl-pyrromethane cofactor linkage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.129659 0 0.241738 0.241185 0.26948 GO:0018298 protein-chromophore linkage biological_process Escherichia Escherichia coli 0.0457645 0 0 0 0 0.0304632 GO:0018298 protein-chromophore linkage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.265935 0.196403 0.151828 0 0.0730737 0 GO:0018307 enzyme active site formation biological_process Clostridium Clostridium thermocellum 0.0764362 0.299178 0.290079 0.637695 0.418042 0.414617 GO:0018339 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid biological_process Clostridium Clostridium thermocellum 1.48308 13.9746 12.425 28.6716 24.4524 24.9415 GO:0018339 peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid biological_process Escherichia Escherichia coli 0.0978481 0 0 0 0 0 GO:0018364 peptidyl-glutamine methylation biological_process Clostridium Clostridium thermocellum 1.69703 8.97286 6.41728 11.9222 13.9485 13.8792 GO:0018364 peptidyl-glutamine methylation biological_process Escherichia Escherichia coli 0.0620482 0 0 0 0 0 GO:0018378 cytochrome c-heme linkage via heme-L-cysteine biological_process Escherichia Escherichia coli 0.0655237 0 0.100903 0 0 0 GO:0018455 alcohol dehydrogenase [NAD(P)+] activity molecular_function Escherichia Escherichia coli 0.0479276 0 0 0 0 0 GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity molecular_function Clostridium Clostridium thermocellum 0.130416 31.3103 29.1451 43.3765 37.6878 33.5279 GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0834844 0 0 0.294885 0.159451 0.11144 GO:0018493 formylmethanofuran dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.53774 3.50888 3.31902 2.70077 1.62173 2.40061 GO:0018537 coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 7.03269 3.21927 8.41721 8.43702 7.34774 17.9235 GO:0018580 nitronate monooxygenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 90.8081 8.77324 9.87973 39.3985 47.2665 24.2261 GO:0018697 carbonyl sulfide nitrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.545869 1.22402 0.7655 2.14768 0.836213 1.36341 GO:0018738 S-formylglutathione hydrolase activity molecular_function Escherichia Escherichia coli 0.0710651 0 0 0 0 0 GO:0018741 alkyl sulfatase activity molecular_function Escherichia Escherichia coli 0.0264671 0 0 0 0 0 GO:0018759 methenyltetrahydromethanopterin cyclohydrolase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.209234 0.459268 0.166442 0.428189 0.160406 0.874961 GO:0018801 glutaconyl-CoA decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.7383 13.8552 10.5367 15.8808 17.9128 16.441 GO:0018937 nitroglycerin metabolic process biological_process Escherichia Escherichia coli 0.165389 0 0 0 0 0 GO:0019003 GDP binding molecular_function Escherichia Escherichia coli 0.0286545 0 0 0 0 0 GO:0019073 viral DNA genome packaging biological_process Escherichia Escherichia coli 20.3105 0 23.4071 0 0 18.4157 GO:0019076 viral release from host cell biological_process Escherichia Escherichia coli 0.209817 0 0.588457 0 0 0.0758994 GO:0019104 DNA N-glycosylase activity molecular_function Clostridium Clostridium thermocellum 8.44359 38.6602 41.3978 94.1453 87.3801 154.826 GO:0019104 DNA N-glycosylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.8755 10.1067 11.4614 13.4119 20.5167 15.9538 GO:0019104 DNA N-glycosylase activity molecular_function Escherichia Escherichia coli 0.100011 0 0 0 0 0 GO:0019104 DNA N-glycosylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.164322 0.045388 0.235607 0.293152 GO:0019107 myristoyltransferase activity molecular_function Escherichia Escherichia coli 0.029578 0 0 0 0 0 GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity molecular_function Clostridium Clostridium thermocellum 6.26833 35.7007 27.2547 96.8199 94.1636 84.6506 GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.0894 14.1176 12.1005 34.4997 35.4584 19.8786 GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity molecular_function Escherichia Escherichia coli 0.019905 0 0.0738842 0 0 0 GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.151609 0.166391 0.200994 0.15514 0.116067 0.172948 GO:0019143 3-deoxy-manno-octulosonate-8-phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.21633 0 0 0 GO:0019144 ADP-sugar diphosphatase activity molecular_function Escherichia Escherichia coli 0.118264 0 0 0 0 0 GO:0019146 arabinose-5-phosphate isomerase activity molecular_function Escherichia Escherichia coli 0 0 0.107759 0 0 0.0772576 GO:0019148 D-cysteine desulfhydrase activity molecular_function Escherichia Escherichia coli 0.0580624 0 0.107759 0 0 0 GO:0019159 nicotinamide-nucleotide amidase activity molecular_function Escherichia Escherichia coli 0.0696311 0 0 0 0 0 GO:0019164 pyruvate synthase activity molecular_function Clostridium Clostridium thermocellum 37.7541 467.125 390.5 1143.26 1120.48 917.719 GO:0019164 pyruvate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.102 15.7809 22.2174 16.6257 21.7097 12.2023 GO:0019164 pyruvate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.082415 0 0.283448 0.430328 0.559241 0.166028 GO:0019172 glyoxalase III activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.175277 GO:0019180 dTDP-4-amino-4,6-dideoxygalactose transaminase activity molecular_function Escherichia Escherichia coli 0 0 0.0459634 0 0 0 GO:0019239 deaminase activity molecular_function Clostridium Clostridium thermocellum 0 53.2952 41.7632 133.282 125.444 119.676 GO:0019242 methylglyoxal biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 8.8476 8.17008 7.28098 5.97475 7.36417 4.43159 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione biological_process Escherichia Escherichia coli 0.226611 0 0.148851 0 0 0.175277 GO:0019249 lactate biosynthetic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.175277 GO:0019251 anaerobic cobalamin biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.196916 0.379841 0.419758 0.457866 1.36338 GO:0019253 reductive pentose-phosphate cycle biological_process Escherichia Escherichia coli 0.11593 0 0 0 0 0.1225 GO:0019262 N-acetylneuraminate catabolic process biological_process Escherichia Escherichia coli 0.205345 0 0 0 0 0.0434635 GO:0019264 glycine biosynthetic process from serine biological_process Clostridium Clostridium thermocellum 2.54412 52.7806 35.9423 179.599 189.141 149.235 GO:0019264 glycine biosynthetic process from serine biological_process Coprothermobacter Coprothermobacter proteolyticus 22.6804 11.9841 12.0337 8.85192 9.73997 6.94814 GO:0019264 glycine biosynthetic process from serine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.106889 0.164198 0.236042 0.436595 0.0381754 0.0853423 GO:0019272 L-alanine biosynthetic process from pyruvate biological_process Escherichia Escherichia coli 0.0446465 0 0 0 0 0 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process biological_process Clostridium Clostridium thermocellum 15.7121 94.3411 68.7886 205.784 178.629 204.708 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 22.7477 23.8692 17.1089 21.6449 23.5611 21.4403 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process biological_process Escherichia Escherichia coli 0.0600067 0 0.0812816 0 0 0 GO:0019281 L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine biological_process Clostridium Clostridium thermocellum 1.80171 18.6499 14.2566 39.4573 34.2343 40.4424 GO:0019281 L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine biological_process Escherichia Escherichia coli 0.155789 0 0.346913 0 0 0 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine biological_process Clostridium Clostridium thermocellum 1.90797 8.33124 5.07952 33.3417 25.5352 24.3338 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine biological_process Coprothermobacter Coprothermobacter proteolyticus 22.4369 12.727 27.7473 8.96712 12.2831 20.0084 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.525672 1.42523 1.09036 0.253054 0.414178 0.369989 GO:0019285 glycine betaine biosynthetic process from choline biological_process Escherichia Escherichia coli 0.086328 0 0.162338 0 0 0.0355404 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0638711 0 0 0.0326296 0.0569702 0 GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway biological_process Clostridium Clostridium thermocellum 17.5654 96.757 66.0977 306.882 268.141 243.195 GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway biological_process Coprothermobacter Coprothermobacter proteolyticus 42.2315 46.6955 32.9517 47.2494 54.0949 40.364 GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway biological_process Escherichia Escherichia coli 0.219709 0 0 0 0 0 GO:0019290 siderophore biosynthetic process biological_process Escherichia Escherichia coli 0.0814186 0 0 0 0 0 GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process biological_process Escherichia Escherichia coli 0 0 0.0639608 0 0 0 GO:0019295 coenzyme M biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.912739 1.67978 1.961 2.31954 1.29925 1.0969 GO:0019298 coenzyme B biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.18198 0.0879123 0.242384 0.0846197 0 GO:0019299 rhamnose metabolic process biological_process Clostridium Clostridium thermocellum 5.56439 29.6624 24.26 87.8646 80.5556 79.0305 GO:0019299 rhamnose metabolic process biological_process Escherichia Escherichia coli 0.17375 0 0 0 0 0.232064 GO:0019301 rhamnose catabolic process biological_process Escherichia Escherichia coli 0.13795 0 0 0 0 0 GO:0019303 D-ribose catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.691985 1.13095 2.00534 0.404388 0.791896 0.524763 GO:0019303 D-ribose catabolic process biological_process Escherichia Escherichia coli 0.148935 0 0 0 0 0.0783571 GO:0019305 dTDP-rhamnose biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 3.26015 1.99964 4.92832 0.722029 1.58891 1.92271 GO:0019305 dTDP-rhamnose biosynthetic process biological_process Escherichia Escherichia coli 0.430036 0 0.12314 0 0 0 GO:0019305 dTDP-rhamnose biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.210813 0.0640362 0.72522 0.15989 0.20162 0.387873 GO:0019316 D-allose catabolic process biological_process Escherichia Escherichia coli 0.0890257 0 0.704922 0 0 0 GO:0019323 pentose catabolic process biological_process Escherichia Escherichia coli 0.0890257 0 0.0933701 0 0 0 GO:0019324 L-lyxose metabolic process biological_process Escherichia Escherichia coli 0.0359457 0 0.267842 0 0 0 GO:0019344 cysteine biosynthetic process biological_process Clostridium Clostridium thermocellum 0.170566 28.8948 17.7178 62.1958 54.7957 58.7528 GO:0019344 cysteine biosynthetic process biological_process Escherichia Escherichia coli 0.119503 0 0 0 0 0 GO:0019354 siroheme biosynthetic process biological_process Clostridium Clostridium thermocellum 0.0182523 12.9279 7.92212 23.4066 22.693 32.3801 GO:0019354 siroheme biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.08384 1.48067 1.34034 1.00281 0.829117 0.892133 GO:0019357 nicotinate nucleotide biosynthetic process biological_process Escherichia Escherichia coli 0.0461534 0 0 0 0 0.0614116 GO:0019358 nicotinate nucleotide salvage biological_process Clostridium Clostridium thermocellum 1.5758 3.20363 4.54108 9.51954 9.20165 8.45937 GO:0019363 pyridine nucleotide biosynthetic process biological_process Escherichia Escherichia coli 0.0696311 0 0 0 0 0 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) biological_process Clostridium Clostridium thermocellum 0.170566 28.8948 17.7178 62.1958 54.7957 58.7528 GO:0019380 3-phenylpropionate catabolic process biological_process Escherichia Escherichia coli 0.172632 0 0.281554 0 0 0 GO:0019386 methanogenesis, from carbon dioxide biological_process Methanothermobacter Methanothermobacter thermautotrophicus 35.4646 20.0618 50.7883 37.8944 33.1387 60.675 GO:0019402 galactitol metabolic process biological_process Escherichia Escherichia coli 0.124996 0 0 0 0 0.07577 GO:0019404 galactitol catabolic process biological_process Escherichia Escherichia coli 0.0436744 0 0.0810561 0 0 0 GO:0019419 sulfate reduction biological_process Escherichia Escherichia coli 0.0639926 0 0 0 0 0 GO:0019427 acetyl-CoA biosynthetic process from acetate biological_process Escherichia Escherichia coli 0.0624857 0 0 0 0 0 GO:0019427 acetyl-CoA biosynthetic process from acetate biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.321105 0.603863 0.128914 0.461639 0 0.431271 GO:0019430 removal of superoxide radicals biological_process Clostridium Clostridium thermocellum 3.34271 26.5836 22.3044 73.621 51.4425 40.9378 GO:0019430 removal of superoxide radicals biological_process Coprothermobacter Coprothermobacter proteolyticus 60.5844 45.6812 40.6282 27.2136 35.3746 29.7026 GO:0019430 removal of superoxide radicals biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.560136 3.79685 1.7356 1.12194 1.27526 1.14176 GO:0019439 aromatic compound catabolic process biological_process Escherichia Escherichia coli 0.244353 0 0.205008 0 0 0 GO:0019441 tryptophan catabolic process to kynurenine biological_process Coprothermobacter Coprothermobacter proteolyticus 15.5656 12.5449 8.71175 11.5431 10.73 8.61288 GO:0019441 tryptophan catabolic process to kynurenine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.320352 0.531379 0.222735 0.184064 0.107169 0.319411 GO:0019464 glycine decarboxylation via glycine cleavage system biological_process Coprothermobacter Coprothermobacter proteolyticus 706.074 325.416 401.597 307.487 371.456 244.037 GO:0019478 D-amino acid catabolic process biological_process Clostridium Clostridium thermocellum 3.31886 15.3888 14.6693 64.3926 55.4333 51.6832 GO:0019478 D-amino acid catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 17.6673 15.5307 13.405 14.5746 16.6134 19.4505 GO:0019491 ectoine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.395184 0.94332 0 0 0 0.131458 GO:0019509 L-methionine biosynthetic process from methylthioadenosine biological_process Clostridium Clostridium thermocellum 1.90797 8.33124 5.07952 33.3417 25.5352 24.3338 GO:0019509 L-methionine biosynthetic process from methylthioadenosine biological_process Coprothermobacter Coprothermobacter proteolyticus 22.4369 12.727 27.7473 8.96712 12.2831 20.0084 GO:0019516 lactate oxidation biological_process Escherichia Escherichia coli 0.176836 0 0.0692383 0 0 0.0506104 GO:0019516 lactate oxidation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 6.10015 1.48707 6.2415 6.12275 5.15822 12.196 GO:0019518 L-threonine catabolic process to glycine biological_process Escherichia Escherichia coli 0.374696 0 0 0 0 0 GO:0019521 D-gluconate metabolic process biological_process Escherichia Escherichia coli 0.431421 0 0.288636 0 0 0.128612 GO:0019538 protein metabolic process biological_process Clostridium Clostridium thermocellum 21.8133 263.562 347.214 110.844 101.05 103.011 GO:0019538 protein metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 525.539 231.02 388.516 41.1582 53.0827 48.5591 GO:0019544 arginine catabolic process to glutamate biological_process Escherichia Escherichia coli 0.241704 0 0 0 0 0 GO:0019545 arginine catabolic process to succinate biological_process Escherichia Escherichia coli 0.241704 0 0 0 0 0 GO:0019546 arginine deiminase pathway biological_process Clostridium Clostridium thermocellum 1.50707 2.58642 1.39825 7.4204 5.77356 4.76255 GO:0019546 arginine deiminase pathway biological_process Escherichia Escherichia coli 0.0620482 0 0 0 0 0 GO:0019547 arginine catabolic process to ornithine biological_process Clostridium Clostridium thermocellum 1.50707 2.58642 1.39825 7.4204 5.77356 4.76255 GO:0019552 glutamate catabolic process via 2-hydroxyglutarate biological_process Coprothermobacter Coprothermobacter proteolyticus 21.7383 13.8552 10.5367 15.8808 17.9128 16.441 GO:0019556 histidine catabolic process to glutamate and formamide biological_process Coprothermobacter Coprothermobacter proteolyticus 22.0551 11.8131 40.4703 1.99762 3.44961 5.27732 GO:0019557 histidine catabolic process to glutamate and formate biological_process Coprothermobacter Coprothermobacter proteolyticus 22.0551 11.8131 40.4703 1.99762 3.44961 5.27732 GO:0019563 glycerol catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0019563 glycerol catabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0350877 GO:0019588 anaerobic glycerol catabolic process biological_process Escherichia Escherichia coli 0.0508684 0 0 0 0 0 GO:0019594 mannitol metabolic process biological_process Escherichia Escherichia coli 0.0797659 0 0.225757 0 0 0 GO:0019605 butyrate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 81.3009 96.7253 101.091 83.5603 101.809 119.134 GO:0019627 urea metabolic process biological_process Clostridium Clostridium thermocellum 0.0764362 0.299178 0.290079 0.637695 0.418042 0.414617 GO:0019630 quinate metabolic process biological_process Clostridium Clostridium thermocellum 1.38574 7.35655 3.7173 17.0606 15.9985 19.0732 GO:0019632 shikimate metabolic process biological_process Clostridium Clostridium thermocellum 1.36543 6.36931 4.52466 37.8689 40.8847 40.2398 GO:0019632 shikimate metabolic process biological_process Escherichia Escherichia coli 0.181527 0 0 0 0 0 GO:0019632 shikimate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.307155 1.98349 0.569964 0.0392948 0.171431 0.306379 GO:0019645 anaerobic electron transport chain biological_process Escherichia Escherichia coli 0.0810054 0 0.252686 0 0 0 GO:0019646 aerobic electron transport chain biological_process Escherichia Escherichia coli 0.146432 0 0.0646374 0 0 0.023187 GO:0019674 NAD metabolic process biological_process Clostridium Clostridium thermocellum 3.27337 43.3958 38.1945 99.6322 94.2849 136.194 GO:0019674 NAD metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 26.7214 39.4559 31.2051 22.3689 30.5419 23.339 GO:0019674 NAD metabolic process biological_process Escherichia Escherichia coli 0.233368 0 0 0 0 0 GO:0019674 NAD metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.207727 0.398826 0.192649 0.070855 0.15459 0 GO:0019693 ribose phosphate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.222333 0.573012 0.41146 0.532295 0.266599 0.446632 GO:0019698 D-galacturonate catabolic process biological_process Escherichia Escherichia coli 1.43953 0 0 0 0 0 GO:0019700 organic phosphonate catabolic process biological_process Escherichia Escherichia coli 0.0798145 0 0 0 0 0 GO:0019740 nitrogen utilization biological_process Escherichia Escherichia coli 0.0551702 0 0 0 0 0 GO:0019752 carboxylic acid metabolic process biological_process Escherichia Escherichia coli 0.298235 0 0 0 0 0 GO:0019808 polyamine binding molecular_function Clostridium Clostridium thermocellum 2.86812 14.2759 7.34115 83.8084 72.8267 32.8495 GO:0019808 polyamine binding molecular_function Escherichia Escherichia coli 0 0 0.181102 0 0 0 GO:0019825 oxygen binding molecular_function Escherichia Escherichia coli 0.0466881 0 0 0 0 0 GO:0019829 cation-transporting ATPase activity molecular_function Clostridium Clostridium thermocellum 5.28287 21.5243 18.7184 79.1633 55.1678 45.7095 GO:0019829 cation-transporting ATPase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.390031 0.365314 0.395041 0.191326 0.0816681 0.210461 GO:0019835 cytolysis biological_process Escherichia Escherichia coli 0.154063 0 0.176907 0 0 0 GO:0019843 rRNA binding molecular_function Clostridium Clostridium thermocellum 332.151 1592.04 935.931 6762.96 5484.78 5699.01 GO:0019843 rRNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 1995.01 1799.96 1399.49 1858.17 2246 1681.5 GO:0019843 rRNA binding molecular_function Escherichia Escherichia coli 0.855989 0 2.05938 0 0 0.40443 GO:0019843 rRNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 7.89043 20.042 37.5021 51.1639 18.2033 27.5042 GO:0019853 L-ascorbic acid biosynthetic process biological_process Escherichia Escherichia coli 0.0540036 0 0 0 0 0 GO:0019854 L-ascorbic acid catabolic process biological_process Escherichia Escherichia coli 0.0683187 0 0 0 0 0 GO:0019856 pyrimidine nucleobase biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 5.1579 4.68626 2.36768 1.02219 2.77335 2.067 GO:0019856 pyrimidine nucleobase biosynthetic process biological_process Escherichia Escherichia coli 0.054198 0 0 0 0 0 GO:0019877 diaminopimelate biosynthetic process biological_process Clostridium Clostridium thermocellum 10.3515 38.2045 33.9355 110.667 117.318 123.081 GO:0019877 diaminopimelate biosynthetic process biological_process Escherichia Escherichia coli 0.121933 0 0 0 0 0 GO:0019877 diaminopimelate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.952354 1.1316 2.39713 2.38761 0.732126 1.87084 GO:0019932 second-messenger-mediated signaling biological_process Clostridium Clostridium thermocellum 4.19311 21.5017 17.5922 87.8474 83.4249 100.137 GO:0020037 heme binding molecular_function Clostridium Clostridium thermocellum 0.268876 23.4922 17.0868 64.5776 54.314 45.8254 GO:0020037 heme binding molecular_function Escherichia Escherichia coli 1.36037 0 0.422737 0 0 0.0680087 GO:0020037 heme binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.126576 0.486199 0.258414 0.155438 0.0676914 0.0673619 GO:0022611 dormancy process biological_process Escherichia Escherichia coli 0.0428724 0 0 0 0 0 GO:0022820 potassium ion symporter activity molecular_function Clostridium Clostridium thermocellum 1.88529 7.99094 4.77929 25.7575 26.9227 25.4754 GO:0022820 potassium ion symporter activity molecular_function Escherichia Escherichia coli 0.0557049 0 0 0 0 0 GO:0022857 transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.641821 0 0.523008 0 0 0.102935 GO:0022872 protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.201845 0 0.29901 0 0 0.0426873 GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 92.4241 20.5231 28.3484 18.3597 14.3406 8.53233 GO:0022877 protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity molecular_function Escherichia Escherichia coli 0.0550244 0 0.469873 0 0 0.0209879 GO:0022885 bacteriocin transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 7.07246 25.0548 21.4841 39.2775 35.7906 61.1063 GO:0022889 serine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0443792 0 0 0 0 0 GO:0022891 substrate-specific transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.698766 0 0.306904 0 0 0.0769342 GO:0022900 electron transport chain biological_process Clostridium Clostridium thermocellum 27.3023 113.233 112.84 293.625 296.322 288.779 GO:0022900 electron transport chain biological_process Escherichia Escherichia coli 0.0534689 0 0.297747 0 0 0 GO:0022904 respiratory electron transport chain biological_process Escherichia Escherichia coli 0.395208 0 0.108165 0 0 0.0508367 GO:0023014 signal transduction by protein phosphorylation biological_process Escherichia Escherichia coli 0.571121 0 0.500184 0 0 0.103032 GO:0030001 metal ion transport biological_process Clostridium Clostridium thermocellum 24.9573 165.741 102.104 716.088 559.563 560.753 GO:0030001 metal ion transport biological_process Coprothermobacter Coprothermobacter proteolyticus 10.7306 9.79903 8.87016 6.29811 7.3781 6.73538 GO:0030001 metal ion transport biological_process Escherichia Escherichia coli 0.14072 0 0 0 0 0 GO:0030001 metal ion transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.296339 0.31612 0 0.269493 0.176445 0.131458 GO:0030060 L-malate dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.440074 0.281489 0.162202 0.240295 0.104847 0 GO:0030091 protein repair biological_process Clostridium Clostridium thermocellum 0.217497 2.60971 0.706365 3.28263 1.65025 7.94968 GO:0030091 protein repair biological_process Coprothermobacter Coprothermobacter proteolyticus 1.85163 2.10927 1.80651 1.83144 1.68072 1.29517 GO:0030091 protein repair biological_process Escherichia Escherichia coli 0.61742 0 0.170863 0 0 0 GO:0030091 protein repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.610761 0.259319 0.964644 0.359672 0.0430586 0.106039 GO:0030145 manganese ion binding molecular_function Clostridium Clostridium thermocellum 21.8883 203.144 212.555 520.555 460.296 438.792 GO:0030145 manganese ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 30.5053 18.0302 14.1882 22.8974 23.4574 20.9737 GO:0030145 manganese ion binding molecular_function Escherichia Escherichia coli 1.623 0 1.43235 0 0 0.34221 GO:0030145 manganese ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.1594 2.28439 3.22316 2.43329 1.48253 3.45237 GO:0030151 molybdenum ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 13.8821 19.0385 12.9373 17.7183 19.5629 16.2159 GO:0030151 molybdenum ion binding molecular_function Escherichia Escherichia coli 0.758043 0 0 0 0 0.0514188 GO:0030151 molybdenum ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.100011 1.60431 0.342583 0.798878 0.150792 1.45312 GO:0030153 bacteriocin immunity biological_process Escherichia Escherichia coli 0.424738 0 0.188139 0 0 0 GO:0030163 protein catabolic process biological_process Clostridium Clostridium thermocellum 5.84393 40.4205 28.0088 109.896 98.4439 102.769 GO:0030163 protein catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 18.5312 28.6788 32.6612 16.4149 18.2525 20.9937 GO:0030163 protein catabolic process biological_process Escherichia Escherichia coli 0.412172 0 0.100722 0 0 0.0362196 GO:0030163 protein catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.613459 1.5799 1.39239 0.716359 0.489531 1.12297 GO:0030170 pyridoxal phosphate binding molecular_function Clostridium Clostridium thermocellum 61.3959 1793.24 1516.57 1656.84 1637.87 1670.83 GO:0030170 pyridoxal phosphate binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 538.617 260.019 385.875 230.782 249.884 168.924 GO:0030170 pyridoxal phosphate binding molecular_function Escherichia Escherichia coli 1.77874 0 0.977725 0 0 0.136567 GO:0030170 pyridoxal phosphate binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.12535 3.27695 2.84959 4.34625 2.66794 4.28542 GO:0030234 enzyme regulator activity molecular_function Clostridium Clostridium thermocellum 29.5502 131.469 92.9205 281.49 268.928 416.262 GO:0030234 enzyme regulator activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0514188 GO:0030234 enzyme regulator activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.642259 1.17865 0.205956 0.531599 0.464442 1.83536 GO:0030244 cellulose biosynthetic process biological_process Escherichia Escherichia coli 0.0566041 0 0.280742 0 0 0.0229283 GO:0030245 cellulose catabolic process biological_process Clostridium Clostridium thermocellum 360.113 492.19 489.415 1494.12 1317.1 1291.15 GO:0030245 cellulose catabolic process biological_process Escherichia Escherichia coli 0.0761932 0 0 0 0 0 GO:0030246 carbohydrate binding molecular_function Clostridium Clostridium thermocellum 236.158 332.987 319.585 866.912 764.217 811.045 GO:0030246 carbohydrate binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 246.44 87.6649 114.489 82.2803 91.0537 71.6753 GO:0030246 carbohydrate binding molecular_function Escherichia Escherichia coli 4.46643 0 3.38907 0 0 1.25439 GO:0030246 carbohydrate binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.47961 2.4815 1.77877 2.41031 1.75273 3.16953 GO:0030248 cellulose binding molecular_function Clostridium Clostridium thermocellum 96.9815 115.552 93.088 368.944 317.694 349.076 GO:0030254 protein secretion by the type III secretion system biological_process Clostridium Clostridium thermocellum 1.77383 6.01273 5.19088 50.7058 47.3394 37.1062 GO:0030259 lipid glycosylation biological_process Clostridium Clostridium thermocellum 1.58956 8.72969 6.41773 32.6025 24.0076 23.7881 GO:0030259 lipid glycosylation biological_process Coprothermobacter Coprothermobacter proteolyticus 23.0057 10.0247 7.60845 14.6403 15.6966 16.805 GO:0030259 lipid glycosylation biological_process Escherichia Escherichia coli 0.0536877 0 0 0 0 0 GO:0030259 lipid glycosylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0861093 0 0 0 0 0 GO:0030261 chromosome condensation biological_process Clostridium Clostridium thermocellum 35.245 378.631 231.085 1476.91 1305.28 1935.4 GO:0030261 chromosome condensation biological_process Coprothermobacter Coprothermobacter proteolyticus 907.442 2125.74 1515.98 841.108 1142.16 1196.14 GO:0030261 chromosome condensation biological_process Escherichia Escherichia coli 0.109368 0 0 0 0 0 GO:0030266 quinate 3-dehydrogenase (NAD+) activity molecular_function Escherichia Escherichia coli 0.0327619 0 0 0 0 0 GO:0030268 methylenetetrahydromethanopterin dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 6.52795 5.96223 21.7131 10.4726 10.4144 28.2812 GO:0030269 tetrahydromethanopterin S-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 26.7966 9.15881 23.6886 22.4062 18.9856 22.9934 GO:0030270 formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.615063 0.430891 1.07935 0.989756 0.893184 2.66469 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity molecular_function Clostridium Clostridium thermocellum 4.04441 28.8063 16.8272 112.805 85.4843 97.7769 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity molecular_function Escherichia Escherichia coli 0 0 0.199145 0 0 0.21418 GO:0030337 DNA polymerase processivity factor activity molecular_function Escherichia Escherichia coli 0.0136346 0 0 0 0 0 GO:0030337 DNA polymerase processivity factor activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.166118 0.159437 0.0770868 0.595043 0.519394 1.1055 GO:0030388 fructose 1,6-bisphosphate metabolic process biological_process Clostridium Clostridium thermocellum 9.251 187.596 131.683 467.604 448.693 467.214 GO:0030388 fructose 1,6-bisphosphate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 61.2687 66.3204 53.7575 64.3077 73.8739 48.3358 GO:0030393 fructoselysine metabolic process biological_process Escherichia Escherichia coli 0.040928 0 0.0374834 0 0 0 GO:0030409 glutamate formimidoyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 38.7195 12.9166 45.4751 2.07255 4.42169 4.76219 GO:0030410 nicotianamine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.458381 0.165789 0.19869 GO:0030418 nicotianamine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.458381 0.165789 0.19869 GO:0030420 establishment of competence for transformation biological_process Clostridium Clostridium thermocellum 26.4095 282.329 361.857 180.511 165.892 181.106 GO:0030420 establishment of competence for transformation biological_process Escherichia Escherichia coli 0.201602 0 0.187552 0 0 0 GO:0030435 sporulation resulting in formation of a cellular spore biological_process Clostridium Clostridium thermocellum 79.6942 328.256 169.846 1262.16 1104.35 1594.63 GO:0030435 sporulation resulting in formation of a cellular spore biological_process Coprothermobacter Coprothermobacter proteolyticus 225.31 404.169 315.996 283.672 335.978 603.333 GO:0030436 asexual sporulation biological_process Clostridium Clostridium thermocellum 1.06843 21.4712 7.272 53.8536 45.1479 49.5785 GO:0030497 fatty acid elongation biological_process Clostridium Clostridium thermocellum 1.23664 9.73149 5.3981 27.9807 25.9851 38.4535 GO:0030497 fatty acid elongation biological_process Escherichia Escherichia coli 0 0 0.150204 0 0 0 GO:0030515 snoRNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 4.51064 3.85666 1.44687 0 GO:0030541 plasmid partitioning biological_process Escherichia Escherichia coli 0.0836546 0 0 0 0 0 GO:0030573 bile acid catabolic process biological_process Escherichia Escherichia coli 0.157247 0 0 0 0 0 GO:0030599 pectinesterase activity molecular_function Clostridium Clostridium thermocellum 0.218955 0.150196 0.203159 0.495139 0.349135 0.332929 GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity molecular_function Clostridium Clostridium thermocellum 1.5856 8.00737 3.75655 20.4672 19.2295 15.9648 GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 4.67053 4.78465 2.16822 5.04796 4.35649 2.48715 GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity molecular_function Escherichia Escherichia coli 0.0464207 0 0 0 0 0 GO:0030632 D-alanine biosynthetic process biological_process Clostridium Clostridium thermocellum 0.852732 8.32088 5.31565 23.5014 22.1396 20.8272 GO:0030632 D-alanine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 5.03638 4.11012 2.81549 4.96229 3.96708 5.04632 GO:0030632 D-alanine biosynthetic process biological_process Escherichia Escherichia coli 0.0969003 0 0 0 0 0 GO:0030643 cellular phosphate ion homeostasis biological_process Clostridium Clostridium thermocellum 0.873002 8.92465 7.92108 11.9012 13.2486 11.9292 GO:0030643 cellular phosphate ion homeostasis biological_process Coprothermobacter Coprothermobacter proteolyticus 134.535 172.094 104.632 117.972 146.035 117.723 GO:0030643 cellular phosphate ion homeostasis biological_process Escherichia Escherichia coli 0 0 0 0 0 0.112378 GO:0030643 cellular phosphate ion homeostasis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.111434 0.184127 1.56966 0.754758 0.256333 0.805659 GO:0030655 beta-lactam antibiotic catabolic process biological_process Clostridium Clostridium thermocellum 133936 95932 83193.2 37667.8 49698.2 17083.2 GO:0030655 beta-lactam antibiotic catabolic process biological_process Escherichia Escherichia coli 77927.6 0 34222.8 0 0 7845.05 GO:0030674 protein binding, bridging molecular_function Escherichia Escherichia coli 0.0814915 0 0.0755531 0 0 0 GO:0030697 S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity molecular_function Escherichia Escherichia coli 0.0511114 0 0 0 0 0 GO:0030698 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.54783 8.23481 3.57378 33.2139 32.0653 25.7839 GO:0030698 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.3952 25.0556 21.3114 16.3395 17.3561 16.2648 GO:0030699 glycine reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 149.417 194.567 244.91 115.624 154.387 113.778 GO:0030788 precorrin-2 C20-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.177006 0.170032 0 0.226492 0.513556 0.471145 GO:0030798 trans-aconitate 2-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0798145 0 0 0 0 0 GO:0030955 potassium ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 82.4715 172.006 221.728 91.3702 114.013 90.918 GO:0030955 potassium ion binding molecular_function Escherichia Escherichia coli 0.183884 0 0 0 0 0 GO:0030961 peptidyl-arginine hydroxylation biological_process Escherichia Escherichia coli 0.0500177 0 0 0 0 0 GO:0030976 thiamine pyrophosphate binding molecular_function Clostridium Clostridium thermocellum 34.6043 296.207 197.136 815.991 684.099 659 GO:0030976 thiamine pyrophosphate binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 140.286 75.2662 108.498 40.4161 49.8643 52.1933 GO:0030976 thiamine pyrophosphate binding molecular_function Escherichia Escherichia coli 0.213511 0 0.225667 0 0 0.0616379 GO:0030976 thiamine pyrophosphate binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.942924 1.45645 1.49627 1.39118 0.732539 0.439162 GO:0030980 alpha-glucan catabolic process biological_process Escherichia Escherichia coli 0.168573 0 0.129139 0 0 0 GO:0030983 mismatched DNA binding molecular_function Clostridium Clostridium thermocellum 2.98984 19.5161 13.0179 52.0287 52.5978 53.8572 GO:0030983 mismatched DNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 34.6387 33.8197 30.2089 39.5389 47.3924 42.4149 GO:0030983 mismatched DNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.135471 1.14467 1.00474 0.277252 0.241922 0.342437 GO:0031071 cysteine desulfurase activity molecular_function Clostridium Clostridium thermocellum 3.91947 55.9324 51.6661 114.788 99.4343 130.863 GO:0031071 cysteine desulfurase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.138023 0.0884932 0.0854314 0.118083 0.0412138 0.122855 GO:0031119 tRNA pseudouridine synthesis biological_process Clostridium Clostridium thermocellum 1.44257 11.3463 8.44567 28.0432 29.1417 20.7401 GO:0031119 tRNA pseudouridine synthesis biological_process Coprothermobacter Coprothermobacter proteolyticus 0.964506 0.884605 0.57055 1.30193 0.757714 0.359253 GO:0031119 tRNA pseudouridine synthesis biological_process Escherichia Escherichia coli 0.133186 0 0 0 0 0 GO:0031119 tRNA pseudouridine synthesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.752551 0.87625 0.922425 0.569526 0.745864 0.887056 GO:0031154 culmination involved in sorocarp development biological_process Escherichia Escherichia coli 0.0403933 0 0.0750119 0 0 0 GO:0031167 rRNA methylation biological_process Clostridium Clostridium thermocellum 2.10947 15.9748 14.7093 39.1462 36.2457 56.1881 GO:0031167 rRNA methylation biological_process Coprothermobacter Coprothermobacter proteolyticus 3.26581 1.00339 2.54012 1.33674 1.74978 2.77348 GO:0031167 rRNA methylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0615379 0.236635 0.11439 0.0630458 0 0.0819791 GO:0031176 endo-1,4-beta-xylanase activity molecular_function Clostridium Clostridium thermocellum 39.2754 60.4228 57.7899 127.287 102.867 96.3288 GO:0031218 arabinogalactan endo-1,4-beta-galactosidase activity molecular_function Clostridium Clostridium thermocellum 1.0845 6.84132 6.44917 14.4016 15.454 20.6395 GO:0031220 maltodextrin phosphorylase activity molecular_function Escherichia Escherichia coli 0.0643814 0 0.0803795 0 0 0 GO:0031222 arabinan catabolic process biological_process Clostridium Clostridium thermocellum 0.249773 2.9802 2.21887 5.951 5.87756 6.05251 GO:0031280 negative regulation of cyclase activity biological_process Escherichia Escherichia coli 0.108493 0 0 0 0 0 GO:0031297 replication fork processing biological_process Escherichia Escherichia coli 0.0241582 0 0 0 0 0 GO:0031388 organic acid phosphorylation biological_process Coprothermobacter Coprothermobacter proteolyticus 42.8886 9.93042 11.9993 14.1016 15.5978 11.3916 GO:0031388 organic acid phosphorylation biological_process Escherichia Escherichia coli 0.0976051 0 0 0 0 0.129873 GO:0031402 sodium ion binding molecular_function Escherichia Escherichia coli 0.200047 0 0 0 0 0 GO:0031418 L-ascorbic acid binding molecular_function Escherichia Escherichia coli 0.0692422 0 0 0 0 0 GO:0031419 cobalamin binding molecular_function Clostridium Clostridium thermocellum 8.41394 130.346 127.939 169.82 136.309 98.5787 GO:0031419 cobalamin binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 144.278 89.4375 110.055 81.7648 101.578 70.7379 GO:0031419 cobalamin binding molecular_function Escherichia Escherichia coli 0.0381088 0 0.0127651 0 0 0.0549114 GO:0031419 cobalamin binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.84983 1.92543 2.22374 1.59718 0.781131 1.3366 GO:0031460 glycine betaine transport biological_process Escherichia Escherichia coli 0.328907 0 0.042851 0 0 0 GO:0031564 transcription antitermination biological_process Clostridium Clostridium thermocellum 12.7564 60.6285 41.9023 224.412 224.981 181.282 GO:0031564 transcription antitermination biological_process Coprothermobacter Coprothermobacter proteolyticus 73.3022 109.531 86.4041 101.71 134.323 109.123 GO:0031564 transcription antitermination biological_process Escherichia Escherichia coli 0.0795229 0 0 0 0 0.0241572 GO:0031669 cellular response to nutrient levels biological_process Escherichia Escherichia coli 0.25614 0 0 0 0 0 GO:0031956 medium-chain fatty acid-CoA ligase activity molecular_function Escherichia Escherichia coli 0.0767036 0 0 0 0 0.0216994 GO:0031992 energy transducer activity molecular_function Escherichia Escherichia coli 0.0426293 0 0 0 0 0 GO:0032026 response to magnesium ion biological_process Escherichia Escherichia coli 0 0 0.244476 0 0 0.175277 GO:0032049 cardiolipin biosynthetic process biological_process Clostridium Clostridium thermocellum 0.139359 3.14249 2.90972 4.88365 5.64617 5.83995 GO:0032049 cardiolipin biosynthetic process biological_process Escherichia Escherichia coli 0.0368206 0 0.0826348 0 0 0.0296224 GO:0032135 DNA insertion or deletion binding molecular_function Escherichia Escherichia coli 0.315175 0 0 0 0 0 GO:0032196 transposition biological_process Escherichia Escherichia coli 1.22062 0 0.559229 0 0 0.106039 GO:0032238 adenosine transport biological_process Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0032259 methylation biological_process Escherichia Escherichia coli 0.0764849 0 0 0 0 0 GO:0032264 IMP salvage biological_process Escherichia Escherichia coli 0.125603 0 0.23311 0 0 0.309904 GO:0032264 IMP salvage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.634761 0.307761 0.0564054 0.0984227 0 GO:0032297 negative regulation of DNA-dependent DNA replication initiation biological_process Escherichia Escherichia coli 0.12276 0 0.227832 0 0 0 GO:0032324 molybdopterin cofactor biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 85.9615 34.4384 28.4195 35.6175 36.5763 25.4597 GO:0032324 molybdopterin cofactor biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.045643 0.262912 0.253543 0.326694 0.304774 0.455429 GO:0032450 maltose alpha-glucosidase activity molecular_function Escherichia Escherichia coli 0.016867 0 0 0 0 0 GO:0032467 positive regulation of cytokinesis biological_process Escherichia Escherichia coli 0.0424106 0 0 0 0 0 GO:0032508 DNA duplex unwinding biological_process Escherichia Escherichia coli 0.234704 0 0.0936859 0 0 0.0384186 GO:0032543 mitochondrial translation biological_process Escherichia Escherichia coli 0.0469554 0 0 0 0 0 GO:0032549 ribonucleoside binding molecular_function Clostridium Clostridium thermocellum 4.13446 16.721800000000002 9.551 60.1148 58.1994 51.541 GO:0032549 ribonucleoside binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 30.8268 15.7939 11.9398 13.5998 14.9322 7.92765 GO:0032549 ribonucleoside binding molecular_function Escherichia Escherichia coli 0.0313279 0 0.0232749 0 0 0.0166869 GO:0032549 ribonucleoside binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0438688 0.441299 0.490441 0.833547 0.23832 0.189021 GO:0032775 DNA methylation on adenine biological_process Escherichia Escherichia coli 0.0768494 0 0.071268 0 0 0 GO:0032781 positive regulation of ATPase activity biological_process Escherichia Escherichia coli 0.0933276 0 0 0 0 0 GO:0032784 regulation of DNA-templated transcription, elongation biological_process Clostridium Clostridium thermocellum 14.6136 76.1035 52.063 280.642 256.965 244.417 GO:0032784 regulation of DNA-templated transcription, elongation biological_process Coprothermobacter Coprothermobacter proteolyticus 115.488 151.304 113.504 211.533 241.643 188.773 GO:0032784 regulation of DNA-templated transcription, elongation biological_process Escherichia Escherichia coli 0.351534 0 0 0 0 0 GO:0032955 regulation of barrier septum assembly biological_process Clostridium Clostridium thermocellum 15.7858 124.745 96.0914 298.916 275.98 215.301 GO:0032955 regulation of barrier septum assembly biological_process Coprothermobacter Coprothermobacter proteolyticus 41.0953 64.2831 64.2589 61.723 73.4074 44.1752 GO:0032955 regulation of barrier septum assembly biological_process Escherichia Escherichia coli 0.415453 0 0 0 0 0 GO:0032973 amino acid export biological_process Escherichia Escherichia coli 0.162035 0 0 0 0 0.215603 GO:0033094 butane-1,4-diamine:2-oxoglutarate aminotransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 176.201 53.7552 61.3663 40.5953 46.613 27.8041 GO:0033094 butane-1,4-diamine:2-oxoglutarate aminotransferase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0567224 GO:0033212 iron assimilation biological_process Escherichia Escherichia coli 0 0 0.198062 0 0 0 GO:0033228 cysteine export biological_process Escherichia Escherichia coli 0.090168 0 0.0573753 0 0 0.0861185 GO:0033362 lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway biological_process Clostridium Clostridium thermocellum 0.112212 6.54863 14.2787 14.7861 20.8913 21.728 GO:0033362 lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0448896 0.129286 0.499643 0.0459351 0.0400853 0.0298488 GO:0033384 geranyl diphosphate biosynthetic process biological_process Escherichia Escherichia coli 0.129589 0 0 0 0 0 GO:0033387 putrescine biosynthetic process from ornithine biological_process Escherichia Escherichia coli 0.0726691 0 0.0220119 0 0 0 GO:0033388 putrescine biosynthetic process from arginine biological_process Clostridium Clostridium thermocellum 1.78679 13.4693 13.2085 36.5505 39.1243 37.5637 GO:0033499 galactose catabolic process via UDP-galactose biological_process Escherichia Escherichia coli 0.0545626 0 0 0 0 0 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process Escherichia Escherichia coli 0.12327 0 0.0611642 0 0 0 GO:0033543 fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway biological_process Escherichia Escherichia coli 0.039008 0 0.144836 0 0 0 GO:0033554 cellular response to stress biological_process Clostridium Clostridium thermocellum 3.384 11.554 11.2844 33.3054 26.5787 30.8817 GO:0033554 cellular response to stress biological_process Coprothermobacter Coprothermobacter proteolyticus 14.3745 14.8853 9.86895 18.6179 26.4482 29.9665 GO:0033554 cellular response to stress biological_process Escherichia Escherichia coli 0.509097 0 1.91711 0 0 0 GO:0033567 DNA replication, Okazaki fragment processing biological_process Escherichia Escherichia coli 0.0401017 0 0 0 0 0 GO:0033592 RNA strand annealing activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.027294 GO:0033608 formyl-CoA transferase activity molecular_function Escherichia Escherichia coli 0.0441605 0 0 0 0 0 GO:0033611 oxalate catabolic process biological_process Escherichia Escherichia coli 0.0441605 0 0 0 0 0.0418465 GO:0033680 ATP-dependent DNA/RNA helicase activity molecular_function Escherichia Escherichia coli 0.0579166 0 0.0179072 0 0 0.0256771 GO:0033721 aldehyde dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0.0479276 0 0 0 0 0 GO:0033726 aldehyde ferredoxin oxidoreductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 209.021 34.6766 39.8562 70.1212 80.2354 39.5824 GO:0033739 preQ1 synthase activity molecular_function Escherichia Escherichia coli 0.0694853 0 0.129049 0 0 0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.85163 2.10927 1.80651 1.83144 1.68072 1.29517 GO:0033743 peptide-methionine (R)-S-oxide reductase activity molecular_function Escherichia Escherichia coli 0.36789 0 0.170863 0 0 0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.158584 0 0 0.162278 0 0.106039 GO:0033748 hydrogenase (acceptor) activity molecular_function Escherichia Escherichia coli 0.0312793 0 0.0465498 0 0 0 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 1.43953 0 0 0 0 0 GO:0033785 heptose 7-phosphate kinase activity molecular_function Escherichia Escherichia coli 0.0189329 0 0.0702306 0 0 0 GO:0033786 heptose-1-phosphate adenylyltransferase activity molecular_function Escherichia Escherichia coli 0.0189329 0 0.0702306 0 0 0 GO:0033794 sarcosine reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.2407 35.7679 37.5771 30.153 31.4085 22.4047 GO:0033795 betaine reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.2407 35.7679 37.5771 30.153 31.4085 22.4047 GO:0033817 beta-ketoacyl-acyl-carrier-protein synthase II activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 66.4879 3.17819 4.16665 18.499 28.3962 21.9105 GO:0033818 beta-ketoacyl-acyl-carrier-protein synthase III activity molecular_function Clostridium Clostridium thermocellum 4.04767 19.5069 7.83488 91.367 62.7221 37.8774 GO:0033819 lipoyl(octanoyl) transferase activity molecular_function Escherichia Escherichia coli 0.341083 0 0 0 0 0 GO:0033856 pyridoxine 5'-phosphate synthase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0555582 GO:0033862 UMP kinase activity molecular_function Clostridium Clostridium thermocellum 11.3218 67.1234 51.461 159.51 193.93 308.74 GO:0033862 UMP kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 31.9732 40.3057 29.2957 30.9004 30.1003 24.9502 GO:0033862 UMP kinase activity molecular_function Escherichia Escherichia coli 0.0843837 0 0 0 0 0 GO:0033862 UMP kinase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0925984 0 0 0.236316 0.289365 0.123082 GO:0033883 pyridoxal phosphatase activity molecular_function Escherichia Escherichia coli 0.0746134 0 0.138477 0 0 0.0419435 GO:0033897 ribonuclease T2 activity molecular_function Escherichia Escherichia coli 0.0369908 0 0 0 0 0 GO:0033905 xylan endo-1,3-beta-xylosidase activity molecular_function Clostridium Clostridium thermocellum 16.3941 19.9949 19.8209 38.1925 25.6185 20.6253 GO:0033971 hydroxyisourate hydrolase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.246875 GO:0033990 ectoine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.395184 0.94332 0 0 0 0.131458 GO:0034015 L-ribulose-5-phosphate 3-epimerase activity molecular_function Escherichia Escherichia coli 0.0683187 0 0 0 0 0 GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity molecular_function Clostridium Clostridium thermocellum 2.61281 3.63587 3.39479 26.268 33.4033 33.0155 GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.53017 1.38868 0.939701 2.2926 2.8344 2.40446 GO:0034023 5-(carboxyamino)imidazole ribonucleotide mutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.224229 0.322981 0.312136 0.114751 0.175186 0.223753 GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity molecular_function Escherichia Escherichia coli 0.0529585 0 0.0982867 0 0 0 GO:0034038 deoxyhypusine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.125603 0 0 0.28919 0 0.0417172 GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.189038 0.0550169 0.0819791 GO:0034040 lipid-transporting ATPase activity molecular_function Escherichia Escherichia coli 0.150977 0 0 0 0 0.040456 GO:0034194 D-galactonate catabolic process biological_process Escherichia Escherichia coli 0.216379 0 0 0 0 0 GO:0034198 cellular response to amino acid starvation biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0362842 GO:0034200 D,D-heptose 1,7-bisphosphate phosphatase activity molecular_function Escherichia Escherichia coli 0.114108 0 0.21227 0 0 0 GO:0034213 quinolinate catabolic process biological_process Escherichia Escherichia coli 0.0653293 0 0 0 0 0 GO:0034219 carbohydrate transmembrane transport biological_process Escherichia Escherichia coli 0.699835 0 0.245965 0 0 0.108206 GO:0034220 ion transmembrane transport biological_process Escherichia Escherichia coli 0.466103 0 0 0 0 0.102676 GO:0034224 cellular response to zinc ion starvation biological_process Escherichia Escherichia coli 0.0484137 0 0 0 0 0 GO:0034227 tRNA thio-modification biological_process Clostridium Clostridium thermocellum 1.60429 7.88873 6.48377 27.1068 28.7997 21.395 GO:0034227 tRNA thio-modification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.427095 0.271734 0.79518 0.582508 0.353779 0.573821 GO:0034257 nicotinamide riboside transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 0.0875918 4.78624 2.8431 6.88935 7.03481 9.66661 GO:0034567 chromate reductase activity molecular_function Escherichia Escherichia coli 0.165389 0 0 0 0 0 GO:0034599 cellular response to oxidative stress biological_process Escherichia Escherichia coli 0.0685131 0 0 0 0 0 GO:0034618 arginine binding molecular_function Clostridium Clostridium thermocellum 1.71324 12.8289 13.414 29.8852 32.2591 32.9507 GO:0034618 arginine binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 58.4295 48.081 48.318600000000004 16.422 24.8708 34.0323 GO:0034618 arginine binding molecular_function Escherichia Escherichia coli 0.234947 0 0.154985 0 0 0 GO:0034628 'de novo' NAD biosynthetic process from aspartate biological_process Escherichia Escherichia coli 0.0653293 0 0 0 0 0 GO:0034639 L-amino acid efflux transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.162035 0 0 0 0 0.215603 GO:0034661 ncRNA catabolic process biological_process Escherichia Escherichia coli 0.0135617 0 0 0 0 0.0352171 GO:0034700 allulose 6-phosphate 3-epimerase activity molecular_function Escherichia Escherichia coli 0.0890257 0 0 0 0 0 GO:0034775 glutathione transmembrane transport biological_process Escherichia Escherichia coli 0.090168 0 0.0573753 0 0 0 GO:0034979 NAD-dependent protein deacetylase activity molecular_function Clostridium Clostridium thermocellum 6.95135 45.9196 41.1006 72.7585 83.0025 129.835 GO:0034979 NAD-dependent protein deacetylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.0074 73.6862 90.1666 38.8953 49.7602 41.129 GO:0035312 5'-3' exodeoxyribonuclease activity molecular_function Escherichia Escherichia coli 0 0 0.116555 0 0 0.0883498 GO:0035344 hypoxanthine transport biological_process Escherichia Escherichia coli 0.0803249 0 0 0 0 0.0530681 GO:0035350 FAD transmembrane transport biological_process Escherichia Escherichia coli 0.0959524 0 0 0 0 0.0780984 GO:0035368 selenocysteine insertion sequence binding molecular_function Escherichia Escherichia coli 0.0286545 0 0 0 0 0 GO:0035429 gluconate transmembrane transport biological_process Escherichia Escherichia coli 0.285791 0 0 0 0 0.164637 GO:0035435 phosphate ion transmembrane transport biological_process Clostridium Clostridium thermocellum 0.234388 1.02869 0.931852 0.376733 0.179353 0.534271 GO:0035435 phosphate ion transmembrane transport biological_process Coprothermobacter Coprothermobacter proteolyticus 64.3583 11.8514 9.56327 18.2278 19.6262 11.0557 GO:0035435 phosphate ion transmembrane transport biological_process Escherichia Escherichia coli 0.247148 0 0.446147 0 0 0 GO:0035435 phosphate ion transmembrane transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.265573 0.128418 0.10622 0.0618316 0 GO:0035438 cyclic-di-GMP binding molecular_function Clostridium Clostridium thermocellum 182.668 464.075 616.926 1359.23 1402.17 1913.17 GO:0035438 cyclic-di-GMP binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 17.7769 64.669 52.0921 28.2876 34.1113 34.4956 GO:0035438 cyclic-di-GMP binding molecular_function Escherichia Escherichia coli 0.0393726 0 0 0 0 0.24639 GO:0035442 dipeptide transmembrane transport biological_process Escherichia Escherichia coli 0.217035 0 0 0 0 0.0780984 GO:0035444 nickel cation transmembrane transport biological_process Escherichia Escherichia coli 0.0848698 0 0.0220119 0 0 0 GO:0035527 3-hydroxypropionate dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0 0 0.151106 0 0 0 GO:0035556 intracellular signal transduction biological_process Escherichia Escherichia coli 0 0 0.442223 0 0 0 GO:0035725 sodium ion transmembrane transport biological_process Escherichia Escherichia coli 0.38189 0 0.0880025 0 0 0.212208 GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 2.75064 26.1507 22.8737 59.1885 55.363 59.7911 GO:0035998 7,8-dihydroneopterin 3'-triphosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 21.0869 27.9668 16.4539 22.0763 24.8876 25.081 GO:0035999 tetrahydrofolate interconversion biological_process Clostridium Clostridium thermocellum 9.03581 91.7583 67.1625 285.092 292.207 268.813 GO:0035999 tetrahydrofolate interconversion biological_process Coprothermobacter Coprothermobacter proteolyticus 149.569 51.323 89.7913 36.9756 52.1917 47.0604 GO:0035999 tetrahydrofolate interconversion biological_process Escherichia Escherichia coli 0.130318 0 0.365136 0 0 0 GO:0036009 protein-glutamine N-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.69703 8.97286 6.41728 11.9222 13.9485 13.8792 GO:0036009 protein-glutamine N-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0620482 0 0 0 0 0 GO:0036094 small molecule binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.912593 1.12829 1.69573 1.86282 1.3843 2.54177 GO:0036104 Kdo2-lipid A biosynthetic process biological_process Escherichia Escherichia coli 0.0942025 0 0 0 0 0 GO:0036108 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0872827 GO:0036131 prostaglandin D2 11-ketoreductase activity molecular_function Escherichia Escherichia coli 0.143394 0 0 0 0 0 GO:0036355 2-iminoacetate synthase activity molecular_function Clostridium Clostridium thermocellum 0.235895 3.02095 6.27362 2.49507 2.07163 1.83132 GO:0036355 2-iminoacetate synthase activity molecular_function Escherichia Escherichia coli 0 0 0.0458281 0 0 0 GO:0036356 cyclic 2,3-diphosphoglycerate synthetase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.156226 0.374836 0.253588 0.199235 0.174296 0.363424 GO:0036361 racemase activity, acting on amino acids and derivatives molecular_function Coprothermobacter Coprothermobacter proteolyticus 53.023 40.5321 36.5296 34.0965 36.1008 39.929 GO:0036361 racemase activity, acting on amino acids and derivatives molecular_function Escherichia Escherichia coli 0.0447681 0 0 0 0 0 GO:0036374 glutathione hydrolase activity molecular_function Escherichia Escherichia coli 0.0455458 0 0 0 0 0 GO:0036380 UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity molecular_function Escherichia Escherichia coli 0.0765578 0 0.0472715 0 0 0 GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.996102 1.67288 1.284 2.39159 0.79411 2.81018 GO:0036439 glycerol-3-phosphate dehydrogenase [NADP+] activity molecular_function Clostridium Clostridium thermocellum 1.81461 8.36484 5.49274 33.4607 32.5297 24.5134 GO:0036439 glycerol-3-phosphate dehydrogenase [NADP+] activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.221021 0.396106 0 0 GO:0040008 regulation of growth biological_process Escherichia Escherichia coli 0.0489484 0 0.0452868 0 0 0 GO:0042026 protein refolding biological_process Clostridium Clostridium thermocellum 4.49499 69.5112 74.5146 100.37 105.77 104.092 GO:0042026 protein refolding biological_process Coprothermobacter Coprothermobacter proteolyticus 50.2588 66.8372 80.2765 34.749 48.1546 40.7722 GO:0042026 protein refolding biological_process Escherichia Escherichia coli 0.0325674 0 0 0 0 0.0432048 GO:0042126 nitrate metabolic process biological_process Escherichia Escherichia coli 0.033734 0 0 0 0 0 GO:0042128 nitrate assimilation biological_process Escherichia Escherichia coli 0.887876 0 0.482954 0 0 0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity molecular_function Escherichia Escherichia coli 0.0870328 0 0 0 0 0 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0701415 0.06735 0.260354 0.0717752 0.156587 0 GO:0042158 lipoprotein biosynthetic process biological_process Clostridium Clostridium thermocellum 1.97208 5.6224 2.38586 18.0107 13.9535 12.5643 GO:0042158 lipoprotein biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 45.9846 64.7185 78.0134 26.6446 31.0394 36.6187 GO:0042158 lipoprotein biosynthetic process biological_process Escherichia Escherichia coli 0.101931 0 0 0 0 0 GO:0042168 heme metabolic process biological_process Escherichia Escherichia coli 0 0 0.0861531 0 0 0 GO:0042173 regulation of sporulation resulting in formation of a cellular spore biological_process Clostridium Clostridium thermocellum 4.93358 18.9337 16.2534 63.1571 73.0955 145.364 GO:0042182 ketone catabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0350877 GO:0042242 cobyrinic acid a,c-diamide synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.14247 0.234488 0.151106 0.208287 0.127222 0.0271 GO:0042244 spore wall assembly biological_process Clostridium Clostridium thermocellum 0.109733 0.31598 0.33938 1.38467 1.63286 1.58095 GO:0042245 RNA repair biological_process Escherichia Escherichia coli 0.112552 0 0.33505 0 0 0 GO:0042245 RNA repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.15365 0.0742451 0.0614043 0.0178615 0 GO:0042254 ribosome biogenesis biological_process Clostridium Clostridium thermocellum 15.3837 60.1888 32.9736 405.225 311.67 206.171 GO:0042254 ribosome biogenesis biological_process Coprothermobacter Coprothermobacter proteolyticus 73.1743 80.7309 66.0647 89.0777 108.378 94.9032 GO:0042254 ribosome biogenesis biological_process Escherichia Escherichia coli 0.0475144 0 0 0 0 0.189668 GO:0042254 ribosome biogenesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.93103 8.44153 2.0946 4.04985 1.97499 4.878 GO:0042256 mature ribosome assembly biological_process Clostridium Clostridium thermocellum 1.39243 22.0746 15.9619 51.3402 47.5091 73.1241 GO:0042256 mature ribosome assembly biological_process Coprothermobacter Coprothermobacter proteolyticus 4.65391 2.99453 3.27865 1.59564 2.6893 3.31622 GO:0042256 mature ribosome assembly biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.260895 0.430999 0.334377 0.436058 GO:0042274 ribosomal small subunit biogenesis biological_process Clostridium Clostridium thermocellum 6.82691 38.931 27.5294 102.83 100.473 77.8864 GO:0042274 ribosomal small subunit biogenesis biological_process Coprothermobacter Coprothermobacter proteolyticus 28.1351 46.0887 41.1475 31.0127 35.2509 32.5146 GO:0042277 peptide binding molecular_function Escherichia Escherichia coli 0.066666 0 0 0 0 0 GO:0042278 purine nucleoside metabolic process biological_process Escherichia Escherichia coli 0.0852829 0 0 0 0 0 GO:0042279 nitrite reductase (cytochrome, ammonia-forming) activity molecular_function Escherichia Escherichia coli 0.188502 0 0.139875 0 0 0 GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity molecular_function Clostridium Clostridium thermocellum 0.235652 6.17217 6.24254 13.548 10.6005 11.2315 GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity molecular_function Escherichia Escherichia coli 0.124024 0 0.0634195 0 0 0 GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.109174 0.0838725 0.121562 0.0893584 0.155979 0.232452 GO:0042301 phosphate ion binding molecular_function Escherichia Escherichia coli 0.109077 0 0.202663 0 0 0 GO:0042355 L-fucose catabolic process biological_process Escherichia Escherichia coli 0.0539064 0 0.0554808 0 0 0 GO:0042398 cellular modified amino acid biosynthetic process biological_process Escherichia Escherichia coli 0.0496775 0 0 0 0 0 GO:0042450 arginine biosynthetic process via ornithine biological_process Clostridium Clostridium thermocellum 1.62409 2.70049 1.06591 12.8661 7.55014 6.66527 GO:0042450 arginine biosynthetic process via ornithine biological_process Escherichia Escherichia coli 0.0416328 0 0.079748 0 0 0 GO:0042450 arginine biosynthetic process via ornithine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.193217 0.185668 0.179343 0.197842 0.120864 0.0257418 GO:0042493 response to drug biological_process Escherichia Escherichia coli 0.678982 0 0.178802 0 0 0 GO:0042542 response to hydrogen peroxide biological_process Escherichia Escherichia coli 0.198613 0 0.071674 0 0 0 GO:0042545 cell wall modification biological_process Clostridium Clostridium thermocellum 0.218955 0.150196 0.203159 0.495139 0.349135 0.332929 GO:0042558 pteridine-containing compound metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.21198 0.0857394 0.124268 0.0228308 0.0398466 0.0594065 GO:0042558 pteridine-containing compound metabolic process biological_process Escherichia Escherichia coli 0.0137561 0 0.0127651 0 0 0.0549114 GO:0042558 pteridine-containing compound metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 7.51892 2.33312 7.68946 5.3912 4.69493 6.11001 GO:0042577 lipid phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.244476 0 0 0.175277 GO:0042586 peptide deformylase activity molecular_function Clostridium Clostridium thermocellum 3.26197 24.2374 17.2553 68.291 73.0949 91.074700000000007 GO:0042586 peptide deformylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 6.56953 11.5923 8.82682 10.5893 13.7341 15.6364 GO:0042586 peptide deformylase activity molecular_function Escherichia Escherichia coli 0.197835 0 0.250611 0 0 0.513671 GO:0042602 riboflavin reductase (NADPH) activity molecular_function Escherichia Escherichia coli 0.086012 0 0.23753 0 0 0 GO:0042623 ATPase activity, coupled molecular_function Escherichia Escherichia coli 0.0375984 0 0.0348672 0 0 0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function Clostridium Clostridium thermocellum 15.7479 83.9402 64.7572 181.149 178.438 211.38 GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function Coprothermobacter Coprothermobacter proteolyticus 73.818 66.7374 77.9893 51.3728 54.2119 47.4494 GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function Escherichia Escherichia coli 0.275608 0 0.112991 0 0 0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.368182 0 0.136672 0.0751824 0 0.293993 GO:0042732 D-xylose metabolic process biological_process Escherichia Escherichia coli 0 0 0.0769063 0 0 0 GO:0042742 defense response to bacterium biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0042744 hydrogen peroxide catabolic process biological_process Escherichia Escherichia coli 0.0460319 0 0 0 0 0 GO:0042773 ATP synthesis coupled electron transport biological_process Clostridium Clostridium thermocellum 6.02553 37.0278 21.7994 232.123 203.359 171.832 GO:0042773 ATP synthesis coupled electron transport biological_process Coprothermobacter Coprothermobacter proteolyticus 95.862 59.029 46.6078 82.6894 92.291 53.6019 GO:0042773 ATP synthesis coupled electron transport biological_process Escherichia Escherichia coli 0.169156 0 0.0653591 0 0 0.106557 GO:0042773 ATP synthesis coupled electron transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.438265 0 0 0 0 GO:0042777 plasma membrane ATP synthesis coupled proton transport biological_process Clostridium Clostridium thermocellum 39.0864 407.387 328.627 946.847 865.463 694.314 GO:0042777 plasma membrane ATP synthesis coupled proton transport biological_process Coprothermobacter Coprothermobacter proteolyticus 167.471 117.226 92.5601 112.581 148.865 126.627 GO:0042777 plasma membrane ATP synthesis coupled proton transport biological_process Escherichia Escherichia coli 0.280274 0 0.376683 0 0 0 GO:0042777 plasma membrane ATP synthesis coupled proton transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.76062 0.488906 1.63768 1.46582 1.1552 1.68208 GO:0042781 3'-tRNA processing endoribonuclease activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0942025 0.241209 0.524361 0.321024 0 0.208812 GO:0042802 identical protein binding molecular_function Clostridium Clostridium thermocellum 19.4642 29.2946 29.3989 79.9306 72.7924 81.907 GO:0042802 identical protein binding molecular_function Escherichia Escherichia coli 1.71166 0 1.18499 0 0 0.583846 GO:0042802 identical protein binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.112917 0.216846 0.208346 0.461987 0.478897 0.651629 GO:0042803 protein homodimerization activity molecular_function Escherichia Escherichia coli 0.0323973 0 0 0 0 0.112378 GO:0042803 protein homodimerization activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0476602 0.184127 1.33312 0.689474 0.256333 0.636106 GO:0042819 vitamin B6 biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.996102 1.67288 1.284 2.39159 0.79411 2.81018 GO:0042823 pyridoxal phosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 0.806992 4.3834 5.1142 9.48325 7.42947 10.5914 GO:0042823 pyridoxal phosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 4.07375 7.12706 5.74208 2.3601 3.26514 4.11351 GO:0042823 pyridoxal phosphate biosynthetic process biological_process Escherichia Escherichia coli 0.055875 0 0 0 0 0 GO:0042823 pyridoxal phosphate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.996102 1.67288 1.284 2.39159 0.79411 2.81018 GO:0042834 peptidoglycan binding molecular_function Escherichia Escherichia coli 0.0633607 0 0 0 0 0 GO:0042838 D-glucarate catabolic process biological_process Escherichia Escherichia coli 0.217886 0 0 0 0 0.129873 GO:0042840 D-glucuronate catabolic process biological_process Escherichia Escherichia coli 1.49497 0 0 0 0 0 GO:0042843 D-xylose catabolic process biological_process Escherichia Escherichia coli 0.0744919 0 0 0 0 0.0247716 GO:0042867 pyruvate catabolic process biological_process Escherichia Escherichia coli 0.046445 0 0 0 0 0 GO:0042882 L-arabinose transport biological_process Clostridium Clostridium thermocellum 0.899031 2.69643 3.67495 3.0391 3.53656 4.19044 GO:0042882 L-arabinose transport biological_process Coprothermobacter Coprothermobacter proteolyticus 0.518649 1.61411 2.1228 0.219578 0.28739 0.499668 GO:0042882 L-arabinose transport biological_process Escherichia Escherichia coli 0.26331 0 0.262158 0 0 0.109467 GO:0042884 microcin transport biological_process Escherichia Escherichia coli 0.0769709 0 0.214075 0 0 0 GO:0042888 molybdenum ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.106914 0 0 0 0 0 GO:0042906 xanthine transport biological_process Escherichia Escherichia coli 0.0374282 0 0.0694638 0 0 0 GO:0042907 xanthine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0374282 0 0.0694638 0 0 0 GO:0042912 colicin transmembrane transporter activity molecular_function Escherichia Escherichia coli 0 0 0.117682 0 0 0 GO:0042914 colicin transport biological_process Escherichia Escherichia coli 0.0426293 0 0 0 0 0 GO:0042925 benzoate transporter activity molecular_function Escherichia Escherichia coli 0.0475144 0 0 0 0 0 GO:0042931 enterobactin transporter activity molecular_function Escherichia Escherichia coli 0.0882966 0 0.0819582 0 0 0.0587598 GO:0042936 dipeptide transporter activity molecular_function Escherichia Escherichia coli 0.115323 0 0.253047 0 0 0 GO:0042937 tripeptide transporter activity molecular_function Escherichia Escherichia coli 0.0781618 0 0.218585 0 0 0 GO:0042938 dipeptide transport biological_process Escherichia Escherichia coli 0.0402232 0 0 0 0 0 GO:0042939 tripeptide transport biological_process Escherichia Escherichia coli 0.0347305 0 0 0 0 0 GO:0042942 D-serine transport biological_process Escherichia Escherichia coli 0.098796 0 0 0 0 0 GO:0042945 D-serine transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.098796 0 0 0 0 0 GO:0042953 lipoprotein transport biological_process Escherichia Escherichia coli 0.600091 0 0 0 0 0 GO:0042954 lipoprotein transporter activity molecular_function Escherichia Escherichia coli 0.600091 0 0 0 0 0 GO:0042958 maltodextrin transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0408065 0 0 0 0 0 GO:0042972 licheninase activity molecular_function Clostridium Clostridium thermocellum 1.13682 8.18688 5.5922 7.09522 7.08042 10.4741 GO:0043022 ribosome binding molecular_function Clostridium Clostridium thermocellum 27.5289 152.981 146.049 415.092 385.992 382.287 GO:0043022 ribosome binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 118.63 120.893 91.2068 117.719 108.775 96.5542 GO:0043022 ribosome binding molecular_function Escherichia Escherichia coli 0.108202 0 0.681061 0 0 0 GO:0043022 ribosome binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.299645 1.15242 0.260895 1.35169 0.69126 1.63324 GO:0043023 ribosomal large subunit binding molecular_function Clostridium Clostridium thermocellum 2.44149 14.764 9.49006 44.2985 44.8502 38.8289 GO:0043023 ribosomal large subunit binding molecular_function Escherichia Escherichia coli 1.15634 0 0 0 0 0 GO:0043024 ribosomal small subunit binding molecular_function Escherichia Escherichia coli 0.0375984 0 0.0348672 0 0 0 GO:0043039 tRNA aminoacylation biological_process Coprothermobacter Coprothermobacter proteolyticus 27.0738 37.966 41.1948 36.6099 54.6363 39.6919 GO:0043086 negative regulation of catalytic activity biological_process Escherichia Escherichia coli 0.180142 0 0.072937 0 0 0 GO:0043093 FtsZ-dependent cytokinesis biological_process Clostridium Clostridium thermocellum 84.3489 514.78 368.702 1529.03 1554.37 1943.26 GO:0043093 FtsZ-dependent cytokinesis biological_process Coprothermobacter Coprothermobacter proteolyticus 156.589 152.124 188.689 119.405 144.955 121.273 GO:0043093 FtsZ-dependent cytokinesis biological_process Escherichia Escherichia coli 0.32689 0 0.0662161 0 0 0.0949793 GO:0043093 FtsZ-dependent cytokinesis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 7.95292 10.0726 7.46988 3.24533 2.46094 4.63953 GO:0043094 cellular metabolic compound salvage biological_process Clostridium Clostridium thermocellum 0.81263 4.4486 5.05268 10.4408 12.9069 10.716 GO:0043094 cellular metabolic compound salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 14.6687 10.4423 9.26466 12.7706 15.3251 11.6857 GO:0043094 cellular metabolic compound salvage biological_process Escherichia Escherichia coli 0.180458 0 0 0 0 0.060215 GO:0043103 hypoxanthine salvage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.634761 0.307761 0.0564054 0.0984227 0 GO:0043115 precorrin-2 dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 0.0182523 12.9279 7.92212 23.4066 22.693 32.3801 GO:0043115 precorrin-2 dehydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.38579 2.13658 1.4185 1.57299 1.49333 1.6443 GO:0043136 glycerol-3-phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.180065 0 0 0.193645 GO:0043137 DNA replication, removal of RNA primer biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.232128 0 0.32251 0.475343 0.103718 0.0772576 GO:0043140 ATP-dependent 3'-5' DNA helicase activity molecular_function Escherichia Escherichia coli 0.136953 0 0.0470459 0 0 0.0384186 GO:0043141 ATP-dependent 5'-3' DNA helicase activity molecular_function Clostridium Clostridium thermocellum 1.90991 12.3852 7.99226 25.3602 28.2005 32.8534 GO:0043142 single-stranded DNA-dependent ATPase activity molecular_function Escherichia Escherichia coli 0.0289947 0 0 0 0 0 GO:0043150 DNA synthesis involved in double-strand break repair via homologous recombination biological_process Escherichia Escherichia coli 0.0735927 0 0 0 0 0 GO:0043164 Gram-negative-bacterium-type cell wall biogenesis biological_process Escherichia Escherichia coli 0.0143151 0 0 0 0 0 GO:0043165 Gram-negative-bacterium-type cell outer membrane assembly biological_process Escherichia Escherichia coli 0.350149 0 0.694818 0 0 0 GO:0043169 cation binding molecular_function Clostridium Clostridium thermocellum 1.36577 4.09104 3.84514 25.4212 28.2393 28.5431 GO:0043169 cation binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 71.8698 13.8513 20.8748 10.7321 12.5328 16.2434 GO:0043169 cation binding molecular_function Escherichia Escherichia coli 0.144876 0 0.498696 0 0 0 GO:0043171 peptide catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 3.49947 3.40423 4.12114 2.4798 3.00514 1.70061 GO:0043213 bacteriocin transport biological_process Escherichia Escherichia coli 0.0230889 0 0.654358 0 0 0 GO:0043215 daunorubicin transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.391685 0.32851 0.1772 0 0.225143 GO:0043266 regulation of potassium ion transport biological_process Escherichia Escherichia coli 0.208748 0 0.176185 0 0 0.0427844 GO:0043295 glutathione binding molecular_function Escherichia Escherichia coli 0.0403933 0 0.0750119 0 0 0 GO:0043335 protein unfolding biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0547174 GO:0043335 protein unfolding biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.828574 2.49783 0.874477 1.07929 0.741198 1.43213 GO:0043365 [formate-C-acetyltransferase]-activating enzyme activity molecular_function Clostridium Clostridium thermocellum 19.3677 128.33 125.145 326.89 276.162 251.047 GO:0043365 [formate-C-acetyltransferase]-activating enzyme activity molecular_function Escherichia Escherichia coli 0.1973 0 0.120299 0 0 0 GO:0043419 urea catabolic process biological_process Clostridium Clostridium thermocellum 0.0309634 0.628694 1.87584 1.02724 1.13578 2.2221 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity biological_process Escherichia Escherichia coli 0.0888556 0 0.0854314 0 0 0.0304632 GO:0043462 regulation of ATPase activity biological_process Escherichia Escherichia coli 0 0 0.835325 0 0 0 GO:0043470 regulation of carbohydrate catabolic process biological_process Escherichia Escherichia coli 0.068659 0 0 0 0 0 GO:0043488 regulation of mRNA stability biological_process Escherichia Escherichia coli 0.16534 0 0 0 0 0 GO:0043492 ATPase activity, coupled to movement of substances molecular_function Escherichia Escherichia coli 0.0432126 0 0.214075 0 0 0 GO:0043531 ADP binding molecular_function Escherichia Escherichia coli 0.0324945 0 0 0 0 0.0418465 GO:0043546 molybdopterin cofactor binding molecular_function Escherichia Escherichia coli 0.128252 0 0 0 0 0.0230576 GO:0043565 sequence-specific DNA binding molecular_function Clostridium Clostridium thermocellum 16.3948 223.15 153.314 270.899 253.281 279.903 GO:0043565 sequence-specific DNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 24.3213 16.6139 14.0454 23.2988 30.4672 32.9608 GO:0043565 sequence-specific DNA binding molecular_function Escherichia Escherichia coli 4.04643 0 3.42208 0 0 0.861831 GO:0043565 sequence-specific DNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.65093 8.86467 3.05429 4.25921 1.93126 5.45939 GO:0043571 maintenance of CRISPR repeat elements biological_process Clostridium Clostridium thermocellum 8.10355 3.93972 1.40096 17.8139 13.038 20.0466 GO:0043571 maintenance of CRISPR repeat elements biological_process Coprothermobacter Coprothermobacter proteolyticus 5.5248 2.45653 1.18021 1.52713 3.02595 2.5506 GO:0043571 maintenance of CRISPR repeat elements biological_process Escherichia Escherichia coli 0.0633364 0 0.374338 0 0 0 GO:0043571 maintenance of CRISPR repeat elements biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.442625 0.479618 0.358009 0.029098 0.745387 0.151152 GO:0043621 protein self-association molecular_function Escherichia Escherichia coli 0.0255679 0 0 0 0 0 GO:0043687 post-translational protein modification biological_process Escherichia Escherichia coli 0.0500177 0 0 0 0 0 GO:0043708 cell adhesion involved in biofilm formation biological_process Escherichia Escherichia coli 0.0270747 0 0.0635097 0 0 0.0755436 GO:0043709 cell adhesion involved in single-species biofilm formation biological_process Escherichia Escherichia coli 0.237767 0 0.0414076 0 0 0.251952 GO:0043711 pilus organization biological_process Escherichia Escherichia coli 0.912131 0 0.704742 0 0 0.104067 GO:0043714 (R)-citramalate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0362373 0.139181 0.0672536 0.222513 0 0.192837 GO:0043726 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity molecular_function Escherichia Escherichia coli 0.114885 0 0.131891 0 0 0 GO:0043737 deoxyribonuclease V activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.41664 5.77819 4.71772 5.81506 8.1438 8.24891 GO:0043740 GTP cyclohydrolase IIa activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.526596 0.388931 0.751788 0.828871 0.469695 2.42383 GO:0043752 adenosylcobinamide kinase activity molecular_function Clostridium Clostridium thermocellum 0.176107 3.3816 2.72149 10.0231 7.27764 13.1028 GO:0043755 alpha-ribazole phosphatase activity molecular_function Clostridium Clostridium thermocellum 0.550997 2.53531 1.5333 6.70068 5.21243 4.3977 GO:0043761 archaetidylserine synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.22575 1.77486 1.71368 1.3061 1.02104 1.75351 GO:0043765 T/G mismatch-specific endonuclease activity molecular_function Escherichia Escherichia coli 0.150029 0 0 0 0 0 GO:0043766 Sep-tRNA:Cys-tRNA synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.320984 0.664072 0.412452 0.379046 0.154329 0.262915 GO:0043768 S-ribosylhomocysteine lyase activity molecular_function Escherichia Escherichia coli 0 0 0.492967 0 0 0 GO:0043772 acyl-phosphate glycerol-3-phosphate acyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.9589 11.5427 11.783 46.3819 56.3684 42.4494 GO:0043772 acyl-phosphate glycerol-3-phosphate acyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 299.256 99.4498 85.1809 76.2499 85.699 83.538 GO:0043772 acyl-phosphate glycerol-3-phosphate acyltransferase activity molecular_function Escherichia Escherichia coli 0.103876 0 0 0 0 0 GO:0043773 coenzyme F420-0 gamma-glutamyl ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.159629 0.229914 0.147994 0.366486 0.14248 0.265502 GO:0043781 cobalt-factor II C20-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.177006 0.170032 0 0.226492 0.513556 0.471145 GO:0043801 hexulose-6-phosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0453757 0.172926 0.0842136 0.742945 0.162121 0.332153 GO:0043805 indolepyruvate ferredoxin oxidoreductase activity molecular_function Clostridium Clostridium thermocellum 2.93977 15.4651 10.6259 35.8904 33.2201 36.3226 GO:0043805 indolepyruvate ferredoxin oxidoreductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 134.735 51.7516 89.4588 11.298400000000001 20.3181 42.559 GO:0043805 indolepyruvate ferredoxin oxidoreductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.193801 0.211665 1.02649 1.18665 0.174708 0.591543 GO:0043807 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 108.699 61.6366 47.053 58.4475 66.6334 93.9611 GO:0043807 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0541494 0.156077 0.652057 0.663609 0.313477 0 GO:0043814 phospholactate guanylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.465325 0 0.172802 0.238231 0 0 GO:0043815 phosphoribosylglycinamide formyltransferase 2 activity molecular_function Escherichia Escherichia coli 0 0 0.26297 0 0 0.124181 GO:0043817 phosphosulfolactate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.232565 0.595509 0.863065 1.54662 0.415307 0.670579 GO:0043821 propionyl-CoA:succinate CoA-transferase activity molecular_function Escherichia Escherichia coli 0.0623156 0 0 0 0 0.0829169 GO:0043825 succinylornithine transaminase activity molecular_function Escherichia Escherichia coli 0.0680757 0 0 0 0 0 GO:0043838 phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity molecular_function Escherichia Escherichia coli 0.0630447 0 0 0 0 0 GO:0043884 CO-methylating acetyl-CoA synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.039421200000000003 0 0 0 0.0704043 0.0524537 GO:0043887 melibiose:sodium symporter activity molecular_function Escherichia Escherichia coli 0.142252 0 0.0880025 0 0 0.212208 GO:0043917 ribose 1,5-bisphosphate isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.222333 0.573012 0.41146 0.532295 0.266599 0.446632 GO:0043934 sporulation biological_process Clostridium Clostridium thermocellum 0.109733 0.31598 0.33938 1.38467 1.63286 1.58095 GO:0043937 regulation of sporulation biological_process Clostridium Clostridium thermocellum 0.816179 4.93041 4.15096 24.8279 21.9791 19.7016 GO:0043952 protein transport by the Sec complex biological_process Clostridium Clostridium thermocellum 13.7304 31.2207 19.5836 185.679 124.807 93.6323 GO:0043952 protein transport by the Sec complex biological_process Coprothermobacter Coprothermobacter proteolyticus 81.4106 70.5303 67.6728 60.1239 70.9404 61.7074 GO:0043952 protein transport by the Sec complex biological_process Escherichia Escherichia coli 0.111458 0 0.283087 0 0 0.0273587 GO:0043953 protein transport by the Tat complex biological_process Escherichia Escherichia coli 0.621406 0 0 0 0 0 GO:0043957 acryloyl-CoA reductase (NADP+) activity molecular_function Escherichia Escherichia coli 0.117777 0 0.21845 0 0 0 GO:0044010 single-species biofilm formation biological_process Escherichia Escherichia coli 0.214726 0 0.526166 0 0 1.27302 GO:0044036 cell wall macromolecule metabolic process biological_process Escherichia Escherichia coli 0.0143151 0 0 0 0 0 GO:0044038 cell wall macromolecule biosynthetic process biological_process Escherichia Escherichia coli 0.0765578 0 0.0472715 0 0 0 GO:0044092 negative regulation of molecular function biological_process Escherichia Escherichia coli 0.168767 0 0 0 0 0 GO:0044179 hemolysis in other organism biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0424286 GO:0044183 protein binding involved in protein folding molecular_function Escherichia Escherichia coli 0.702582 0 0.704742 0 0 0 GO:0044205 'de novo' UMP biosynthetic process biological_process Clostridium Clostridium thermocellum 4.99385 32.0568 27.8071 93.7942 102.431 103.234 GO:0044205 'de novo' UMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 11.9763 7.93176 8.68739 2.85556 3.98222 3.30685 GO:0044205 'de novo' UMP biosynthetic process biological_process Escherichia Escherichia coli 0.234145 0 0.0147047 0 0 0 GO:0044205 'de novo' UMP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.28852 4.17673 2.82659 2.96541 2.36777 3.1826 GO:0044206 UMP salvage biological_process Clostridium Clostridium thermocellum 10.1241 63.2315 62.446 131.224 128.121 141.808 GO:0044206 UMP salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 24.2382 38.2105 32.2957 22.7568 21.5793 23.6577 GO:0044206 UMP salvage biological_process Escherichia Escherichia coli 0.0792312 0 0 0 0 0.105683 GO:0044206 UMP salvage biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0975079 0 0.179027 0.149818 0.130738 0 GO:0044208 'de novo' AMP biosynthetic process biological_process Clostridium Clostridium thermocellum 3.47798 25.0905 23.5623 91.833 104.184 82.8417 GO:0044208 'de novo' AMP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 33.6181 21.2865 17.5166 22.9178 27.6806 22.5992 GO:0044208 'de novo' AMP biosynthetic process biological_process Escherichia Escherichia coli 0.103268 0 0 0 0 0 GO:0044208 'de novo' AMP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.288538 0.457168 1.33862 1.72706 0.84025 1.21901 GO:0044209 AMP salvage biological_process Clostridium Clostridium thermocellum 9.88801 36.4396 19.4887 142.417 93.9552 92.2094 GO:0044209 AMP salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 82.9271 58.608 43.511 37.0193 45.5653 50.1944 GO:0044209 AMP salvage biological_process Escherichia Escherichia coli 0.147307 0 0.224404 0 0 0 GO:0044210 'de novo' CTP biosynthetic process biological_process Clostridium Clostridium thermocellum 14.3125 84.6314 61.1861 206.548 245.317 356.629 GO:0044210 'de novo' CTP biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 113.73 71.2217 63.299 59.6361 65.3162 43.5671 GO:0044210 'de novo' CTP biosynthetic process biological_process Escherichia Escherichia coli 0.247707 0 0 0 0 0 GO:0044210 'de novo' CTP biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.226489 0.514297 0.186334 0.818675 0.379063 0.523955 GO:0044211 CTP salvage biological_process Coprothermobacter Coprothermobacter proteolyticus 10.1265 24.3598 14.7753 15.3747 16.4329 16.4033 GO:0044212 transcription regulatory region DNA binding molecular_function Escherichia Escherichia coli 0.423012 0 0.411956 0 0 0.379206 GO:0044237 cellular metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 9.47532 8.33493 8.53972 5.25356 5.34 5.49489 GO:0044238 primary metabolic process biological_process Clostridium Clostridium thermocellum 57.9763 215.103 127.475 832.845 569.085 772.994 GO:0044238 primary metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 42.0218 42.5692 90.504 38.8777 52.7804 48.8106 GO:0044260 cellular macromolecule metabolic process biological_process Clostridium Clostridium thermocellum 0 0 0.267977 0 0.0645879 0.240537 GO:0044262 cellular carbohydrate metabolic process biological_process Escherichia Escherichia coli 0.0890257 0 0.0933701 0 0 0 GO:0044281 small molecule metabolic process biological_process Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:0044283 small molecule biosynthetic process biological_process Escherichia Escherichia coli 0.143856 0 0.138477 0 0 0.0419435 GO:0044318 L-aspartate:fumarate oxidoreductase activity molecular_function Clostridium Clostridium thermocellum 2.029 11.9143 6.784 25.377 25.8602 20.0365 GO:0044318 L-aspartate:fumarate oxidoreductase activity molecular_function Escherichia Escherichia coli 0.0330049 0 0 0 0 0 GO:0044349 DNA excision biological_process Escherichia Escherichia coli 1.42047 0 0 0 0 0 GO:0044571 [2Fe-2S] cluster assembly biological_process Clostridium Clostridium thermocellum 3.91947 55.9324 51.6661 114.788 99.4343 130.863 GO:0044610 FMN transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.0959524 0 0 0 0 0.0780984 GO:0044667 (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity molecular_function Escherichia Escherichia coli 0.0349249 0 0 0 0 0 GO:0044689 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.120913 0.263659 0.169871 0.81472 0.656687 1.09606 GO:0044718 siderophore transmembrane transport biological_process Escherichia Escherichia coli 0 0 0.117682 0 0 0 GO:0044780 bacterial-type flagellum assembly biological_process Clostridium Clostridium thermocellum 33.414 88.8166 65.5319 967.809 899.021 747.531 GO:0044780 bacterial-type flagellum assembly biological_process Escherichia Escherichia coli 0.190665 0 0.386697 0 0 0.0924892 GO:0044781 bacterial-type flagellum organization biological_process Clostridium Clostridium thermocellum 15.7928 45.6453 37.7114 405.282 394.889 280.533 GO:0044781 bacterial-type flagellum organization biological_process Escherichia Escherichia coli 0.0825852 0 0 0 0 0 GO:0044822 poly(A) RNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.45856 0.187441 1.44701 1.9968 1.30741 2.72633 GO:0045127 N-acetylglucosamine kinase activity molecular_function Escherichia Escherichia coli 0.0637981 0 0 0 0 0.0424286 GO:0045148 tripeptide aminopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.49947 3.40423 4.12114 2.4798 3.00514 1.70061 GO:0045150 acetoin catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 115.779 6.00386 9.3934 2.61932 4.8924 1.93923 GO:0045226 extracellular polysaccharide biosynthetic process biological_process Clostridium Clostridium thermocellum 3.49648 43.6705 36.7416 84.3769 98.3134 155.723 GO:0045226 extracellular polysaccharide biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 3.26015 1.99964 4.92832 0.722029 1.58891 1.92271 GO:0045226 extracellular polysaccharide biosynthetic process biological_process Escherichia Escherichia coli 0.599459 0 0.25873 0 0 0.134045 GO:0045226 extracellular polysaccharide biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.210813 0.0640362 0.72522 0.15989 0.20162 0.387873 GO:0045227 capsule polysaccharide biosynthetic process biological_process Clostridium Clostridium thermocellum 3.00262 16.584 8.70638 40.1594 35.961 49.9037 GO:0045227 capsule polysaccharide biosynthetic process biological_process Escherichia Escherichia coli 0.349419 0 0 0 0 0 GO:0045228 slime layer polysaccharide biosynthetic process biological_process Escherichia Escherichia coli 0.232954 0 0.37745 0 0 0 GO:0045330 aspartyl esterase activity molecular_function Clostridium Clostridium thermocellum 0.218955 0.150196 0.203159 0.495139 0.349135 0.332929 GO:0045333 cellular respiration biological_process Escherichia Escherichia coli 0.0717456 0 0.122734 0 0 0.0111569 GO:0045337 farnesyl diphosphate biosynthetic process biological_process Escherichia Escherichia coli 0.129589 0 0 0 0 0 GO:0045437 uridine nucleosidase activity molecular_function Escherichia Escherichia coli 0.153577 0 0 0 0 0 GO:0045454 cell redox homeostasis biological_process Clostridium Clostridium thermocellum 75.2534 772.464 610.22 1880.1 1429.21 2212.82 GO:0045454 cell redox homeostasis biological_process Coprothermobacter Coprothermobacter proteolyticus 75.4945 173.534 241.865 130.534 149.926 105.491 GO:0045454 cell redox homeostasis biological_process Escherichia Escherichia coli 0.953399 0 0.750344 0 0 0.0517099 GO:0045454 cell redox homeostasis biological_process Methanothermobacter Methanothermobacter thermautotrophicus 2.08901 6.07896 3.93481 3.80195 1.70492 2.5984 GO:0045471 response to ethanol biological_process Escherichia Escherichia coli 0.269994 0 0.200453 0 0 0 GO:0045490 pectin catabolic process biological_process Clostridium Clostridium thermocellum 0.218955 0.150196 0.203159 0.495139 0.349135 0.332929 GO:0045490 pectin catabolic process biological_process Escherichia Escherichia coli 0 0 0.0656748 0 0 0 GO:0045493 xylan catabolic process biological_process Clostridium Clostridium thermocellum 29.2106 51.6523 53.1545 97.1435 79.9208 78.4948 GO:0045493 xylan catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 0.227778 0.058342 0 0 0.0135643 0 GO:0045550 geranylgeranyl reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.266154 1.40968 0.781738 1.31692 1.02676 1.37405 GO:0045717 negative regulation of fatty acid biosynthetic process biological_process Clostridium Clostridium thermocellum 2.48606 19.529 5.98408 62.2942 58.1151 35.9727 GO:0045717 negative regulation of fatty acid biosynthetic process biological_process Escherichia Escherichia coli 0.132044 0 0 0 0 0 GO:0045727 positive regulation of translation biological_process Clostridium Clostridium thermocellum 1.05275 13.504 8.41166 25.5348 28.3919 30.655 GO:0045727 positive regulation of translation biological_process Coprothermobacter Coprothermobacter proteolyticus 3.84932 3.72544 2.99596 5.72677 5.91025 4.45378 GO:0045727 positive regulation of translation biological_process Escherichia Escherichia coli 0.0817831 0 0.0622017 0 0 0 GO:0045828 positive regulation of isoprenoid metabolic process biological_process Escherichia Escherichia coli 0.0932304 0 0 0 0 0 GO:0045862 positive regulation of proteolysis biological_process Escherichia Escherichia coli 0.0281198 0 0 0 0 0 GO:0045892 negative regulation of transcription, DNA-templated biological_process Clostridium Clostridium thermocellum 61.3857 237.87 183.623 1112.24 1159.02 1531.92 GO:0045892 negative regulation of transcription, DNA-templated biological_process Coprothermobacter Coprothermobacter proteolyticus 27.5553 51.8725 59.3377 36.2145 42.1951 41.0816 GO:0045892 negative regulation of transcription, DNA-templated biological_process Escherichia Escherichia coli 1.98819 0 2.27895 0 0 0.404204 GO:0045893 positive regulation of transcription, DNA-templated biological_process Escherichia Escherichia coli 2.81635 0 0.931942 0 0 1.34226 GO:0045901 positive regulation of translational elongation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.299645 1.15242 0 0.920692 0.356883 1.19719 GO:0045905 positive regulation of translational termination biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.299645 1.15242 0 0.920692 0.356883 1.19719 GO:0045910 negative regulation of DNA recombination biological_process Clostridium Clostridium thermocellum 1.79646 9.59572 7.45549 24.5317 25.6271 27.6692 GO:0045910 negative regulation of DNA recombination biological_process Coprothermobacter Coprothermobacter proteolyticus 19.9673 19.013 15.8316 20.5905 25.004 19.1869 GO:0045936 negative regulation of phosphate metabolic process biological_process Clostridium Clostridium thermocellum 0.873002 8.92465 7.92108 11.9012 13.2486 11.9292 GO:0045936 negative regulation of phosphate metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 134.535 172.094 104.632 117.972 146.035 117.723 GO:0045936 negative regulation of phosphate metabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.112378 GO:0045936 negative regulation of phosphate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.111434 0.184127 1.56966 0.754758 0.256333 0.805659 GO:0045947 negative regulation of translational initiation biological_process Escherichia Escherichia coli 0.168767 0 0 0 0 0 GO:0045982 negative regulation of purine nucleobase metabolic process biological_process Clostridium Clostridium thermocellum 1.63228 13.8764 9.70138 49.8668 49.5821 67.5221 GO:0046026 precorrin-4 C11-methyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0830956 0.0797652 0 0.0849563 0.111293 0.0551701 GO:0046034 ATP metabolic process biological_process Clostridium Clostridium thermocellum 0.844128 1.36483 0.989498 14.7573 12.6659 10.6787 GO:0046034 ATP metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0151414 0.116311 0.168608 0.123953 0.0946464 0.362616 GO:0046039 GTP metabolic process biological_process Clostridium Clostridium thermocellum 1.23528 7.17098 4.74217 16.84 15.7692 21.3615 GO:0046039 GTP metabolic process biological_process Escherichia Escherichia coli 0.0861822 0 0.159947 0 0 0 GO:0046080 dUTP metabolic process biological_process Clostridium Clostridium thermocellum 4.346 16.0451 11.3653 45.9244 54.2822 67.5313 GO:0046080 dUTP metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 6.62402 13.6576 7.89036 6.861 7.59871 11.9597 GO:0046080 dUTP metabolic process biological_process Escherichia Escherichia coli 0.0786479 0 0 0 0 0 GO:0046080 dUTP metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.159119 0.308093 0 0 0.143261 0 GO:0046104 thymidine metabolic process biological_process Escherichia Escherichia coli 0.0414384 0 0 0 0 0 GO:0046113 nucleobase catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 2.07992 3.38192 3.26796 1.73579 2.60042 1.87404 GO:0046113 nucleobase catabolic process biological_process Escherichia Escherichia coli 0.0620482 0 0 0 0 0 GO:0046133 pyrimidine ribonucleoside catabolic process biological_process Escherichia Escherichia coli 0 0 0.0567438 0 0 0.040844 GO:0046140 corrin biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.581693 1.30481 0.516017 0.416077 0.164313 0.0683321 GO:0046167 glycerol-3-phosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 1.81461 8.36484 5.49274 33.4607 32.5297 24.5134 GO:0046167 glycerol-3-phosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0046167 glycerol-3-phosphate biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.221021 0.396106 0 0 GO:0046168 glycerol-3-phosphate catabolic process biological_process Clostridium Clostridium thermocellum 1.81461 8.36484 5.49274 33.4607 32.5297 24.5134 GO:0046168 glycerol-3-phosphate catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.221021 0.396106 0 0 GO:0046176 aldonic acid catabolic process biological_process Escherichia Escherichia coli 0.0899007 0 0 0 0 0 GO:0046177 D-gluconate catabolic process biological_process Escherichia Escherichia coli 0.100206 0 0 0 0 0 GO:0046183 L-idonate catabolic process biological_process Escherichia Escherichia coli 0.431421 0 0 0 0 0.128612 GO:0046214 enterobactin catabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0307219 GO:0046256 2,4,6-trinitrotoluene catabolic process biological_process Escherichia Escherichia coli 0.165389 0 0 0 0 0 GO:0046279 3,4-dihydroxybenzoate biosynthetic process biological_process Clostridium Clostridium thermocellum 1.38574 7.35655 3.7173 17.0606 15.9985 19.0732 GO:0046294 formaldehyde catabolic process biological_process Escherichia Escherichia coli 0.0710651 0 0 0 0 0 GO:0046296 glycolate catabolic process biological_process Escherichia Escherichia coli 0.0297725 0 0.0829055 0 0 0.0197914 GO:0046316 gluconokinase activity molecular_function Escherichia Escherichia coli 0.247318 0 0 0 0 0 GO:0046336 ethanolamine catabolic process biological_process Escherichia Escherichia coli 0.0953205 0 0.27339 0 0 0.221715 GO:0046348 amino sugar catabolic process biological_process Escherichia Escherichia coli 0.071381 0 0 0 0 0.0951734 GO:0046356 acetyl-CoA catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0396156 0 0.0734782 0.0405383 0 0 GO:0046365 monosaccharide catabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0350877 GO:0046373 L-arabinose metabolic process biological_process Clostridium Clostridium thermocellum 4.20574 10.9966 12.1554 20.5277 18.1504 28.5563 GO:0046386 deoxyribose phosphate catabolic process biological_process Clostridium Clostridium thermocellum 2.09353 22.1003 15.1099 60.3665 37.74 60.8098 GO:0046386 deoxyribose phosphate catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 19.2405 14.345 7.7744 13.2134 16.1646 16.8584 GO:0046386 deoxyribose phosphate catabolic process biological_process Escherichia Escherichia coli 0.0771654 0 0 0 0 0 GO:0046386 deoxyribose phosphate catabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.370175 0.347438 0.257738 0.142033 0.0826881 0.18514 GO:0046392 galactarate catabolic process biological_process Escherichia Escherichia coli 0.266859 0 0 0 0 0.129873 GO:0046416 D-amino acid metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 13.8998 8.65483 7.6177 10.4077 13.1879 9.88361 GO:0046416 D-amino acid metabolic process biological_process Escherichia Escherichia coli 0.0580624 0 0.107759 0 0 0 GO:0046417 chorismate metabolic process biological_process Escherichia Escherichia coli 0.0721101 0 0 0 0 0 GO:0046417 chorismate metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.16534 0 0.306859 0 0.420168 0.432759 GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity molecular_function Clostridium Clostridium thermocellum 4.0625 26.2796 22.4198 63.5567 64.0331 72.5068 GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.1685 18.7323 11.0275 18.782 17.4483 13.3658 GO:0046444 FMN metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0794256 0.457588 0.588683 1.70599 0.70834 0.422734 GO:0046459 short-chain fatty acid metabolic process biological_process Escherichia Escherichia coli 0.0336125 0 0.211098 0 0 0.24694 GO:0046467 membrane lipid biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.266154 1.40968 0.781738 1.31692 1.02676 1.37405 GO:0046474 glycerophospholipid biosynthetic process biological_process Escherichia Escherichia coli 0 0 0.244476 0 0 0.175277 GO:0046474 glycerophospholipid biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.162837 0 0.37763 0.291528 0.327171 0.378915 GO:0046487 glyoxylate metabolic process biological_process Escherichia Escherichia coli 0.0661313 0 0 0 0 0 GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity molecular_function Clostridium Clostridium thermocellum 1.90797 8.33124 5.07952 33.3417 25.5352 24.3338 GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 22.4369 12.727 27.7473 8.96712 12.2831 20.0084 GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.525672 1.42523 1.09036 0.253054 0.414178 0.369989 GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity molecular_function Clostridium Clostridium thermocellum 13.9913 125.801 107.824 489.74 487.58 612.883 GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity molecular_function Escherichia Escherichia coli 0.052278 0 0 0 0 0 GO:0046537 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0908972 0.262726 0.0834919 0.673582 0.16236 0.150829 GO:0046538 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 55.8674 437.949 223.846 234.611 312.144 253.308 GO:0046553 D-malate dehydrogenase (decarboxylating) activity molecular_function Escherichia Escherichia coli 0 0 0.0963923 0 0 0 GO:0046555 acetylxylan esterase activity molecular_function Clostridium Clostridium thermocellum 7.87794 11.7939 11.5945 20.9763 16.3192 17.9495 GO:0046556 alpha-L-arabinofuranosidase activity molecular_function Clostridium Clostridium thermocellum 4.20574 10.9966 12.1554 20.5277 18.1504 28.5563 GO:0046618 drug export biological_process Escherichia Escherichia coli 0.265619 0 0 0 0 0 GO:0046654 tetrahydrofolate biosynthetic process biological_process Clostridium Clostridium thermocellum 4.67126 33.8886 28.8079 80.9409 73.8015 74.2593 GO:0046654 tetrahydrofolate biosynthetic process biological_process Escherichia Escherichia coli 0.397031 0 0.514032 0 0 0 GO:0046656 folic acid biosynthetic process biological_process Clostridium Clostridium thermocellum 1.92063 7.73797 5.93419 21.7524 18.4385 14.4682 GO:0046656 folic acid biosynthetic process biological_process Escherichia Escherichia coli 0.331605 0 0.148851 0 0 0 GO:0046657 folic acid catabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0557199 GO:0046677 response to antibiotic biological_process Clostridium Clostridium thermocellum 133937 95941.1 83198.5 37694.8 49718 17106.2 GO:0046677 response to antibiotic biological_process Coprothermobacter Coprothermobacter proteolyticus 9.94741 5.0141 2.59939 7.62938 7.53182 5.54085 GO:0046677 response to antibiotic biological_process Escherichia Escherichia coli 77929.1 0 34225.6 0 0 7845.75 GO:0046685 response to arsenic-containing substance biological_process Escherichia Escherichia coli 0 0 0.0395583 0 0 0.185755 GO:0046685 response to arsenic-containing substance biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.295351 0.0951744 0.209879 0 0.449996 GO:0046686 response to cadmium ion biological_process Escherichia Escherichia coli 0.0721344 0 0.0220119 0 0 0 GO:0046688 response to copper ion biological_process Escherichia Escherichia coli 0.316682 0 0 0 0 0 GO:0046718 viral entry into host cell biological_process Escherichia Escherichia coli 15.5896 0 16.7385 0 0 15.7476 GO:0046777 protein autophosphorylation biological_process Escherichia Escherichia coli 0.542758 0 0.142265 0 0 0 GO:0046790 virion binding molecular_function Escherichia Escherichia coli 0.0348277 0 0 0 0 0 GO:0046797 viral procapsid maturation biological_process Escherichia Escherichia coli 15.7062 0 20.3094 0 0 17.5375 GO:0046820 4-amino-4-deoxychorismate synthase activity molecular_function Escherichia Escherichia coli 0.0401017 0 0.148851 0 0 0 GO:0046834 lipid phosphorylation biological_process Escherichia Escherichia coli 0 0 0.300724 0 0 0 GO:0046835 carbohydrate phosphorylation biological_process Escherichia Escherichia coli 0.460051 0 1.23943 0 0 0.0247716 GO:0046839 phospholipid dephosphorylation biological_process Escherichia Escherichia coli 0 0 0.244476 0 0 0.175277 GO:0046854 phosphatidylinositol phosphorylation biological_process Coprothermobacter Coprothermobacter proteolyticus 37.3761 42.5571 34.4422 32.5891 40.4493 39.8263 GO:0046854 phosphatidylinositol phosphorylation biological_process Escherichia Escherichia coli 0 0 0.27587 0 0 0 GO:0046854 phosphatidylinositol phosphorylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0701415 0.06735 0.260354 0.0717752 0.156587 0 GO:0046855 inositol phosphate dephosphorylation biological_process Escherichia Escherichia coli 0 0 0.27587 0 0 0 GO:0046857 oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor molecular_function Escherichia Escherichia coli 0.234874 0 0.129049 0 0 0 GO:0046870 cadmium ion binding molecular_function Escherichia Escherichia coli 0.0484137 0 0 0 0 0 GO:0046872 metal ion binding molecular_function Clostridium Clostridium thermocellum 637.316 3232.35 2454.26 9667.48 8203.48 9482.64 GO:0046872 metal ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 2580.65 2572.22 2601.62 1853.15 2273.33 1995.7 GO:0046872 metal ion binding molecular_function Escherichia Escherichia coli 23.5591 0 27.1815 0 0 17.6502 GO:0046872 metal ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 29.4427 39.9169 36.3039 44.4933 25.18 38.1282 GO:0046873 metal ion transmembrane transporter activity molecular_function Clostridium Clostridium thermocellum 10.2384 85.9525 69.6178 190.811 184.224 229.896 GO:0046873 metal ion transmembrane transporter activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.9464 21.2467 22.6546 14.1468 16.0176 13.2948 GO:0046873 metal ion transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.532599 0 0.289132 0 0 0 GO:0046873 metal ion transmembrane transporter activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.148189 0 0 0 0 GO:0046892 peptidyl-S-carbamoyl-L-cysteine dehydration biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0375455 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer molecular_function Clostridium Clostridium thermocellum 6.07001 49.1346 31.9077 100.8 94.2191 107.021 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0350707 0.06735 0.128598 0.427244 0.297894 0.5019 GO:0046914 transition metal ion binding molecular_function Clostridium Clostridium thermocellum 8.52696 48.5364 33.3028 91.0216 90.0693 179.452 GO:0046914 transition metal ion binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.6478 11.8481 7.42383 5.30415 6.56615 7.80654 GO:0046914 transition metal ion binding molecular_function Escherichia Escherichia coli 0.120767 0 0 0 0 0.0384186 GO:0046914 transition metal ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.80653 3.52302 2.83773 1.62066 1.52589 2.20179 GO:0046917 triphosphoribosyl-dephospho-CoA synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0632878 0 0.0587285 0.0645628 0.113029 0.0842105 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function Clostridium Clostridium thermocellum 39.0864 407.387 328.627 946.847 865.463 694.314 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function Coprothermobacter Coprothermobacter proteolyticus 183.204 126.744 100.241 127.327 168.807 136.313 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function Escherichia Escherichia coli 0.280274 0 0.376683 0 0 0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.76062 0.488906 1.63768 1.46582 1.1552 1.68208 GO:0046944 protein carbamoylation biological_process Clostridium Clostridium thermocellum 0.241607 3.27014 1.08914 9.48984 7.39755 8.80261 GO:0046944 protein carbamoylation biological_process Coprothermobacter Coprothermobacter proteolyticus 5.79985 8.39756 4.91912 6.8849 7.22312 7.9444 GO:0046944 protein carbamoylation biological_process Escherichia Escherichia coli 0 0 0.0214706 0 0 0 GO:0046944 protein carbamoylation biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0714782 0.343191 0.442223 0.231615 0.0850971 0.110825 GO:0046952 ketone body catabolic process biological_process Escherichia Escherichia coli 0.0336125 0 0.0312136 0 0 0.24694 GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function Clostridium Clostridium thermocellum 15.4849 150.642 114.174 394.142 360.224 266.265 GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function Coprothermobacter Coprothermobacter proteolyticus 51.5972 34.4361 30.137 39.0334 51.421 33.217 GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function Escherichia Escherichia coli 0.0680757 0 0.252415 0 0 0 GO:0046961 proton-transporting ATPase activity, rotational mechanism molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0633607 0.162611 0.622377 0.595192 0.44823 0.779594 GO:0046982 protein heterodimerization activity molecular_function Escherichia Escherichia coli 0.0735441 0 0.0675693 0 0 0.0557199 GO:0046982 protein heterodimerization activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.996102 1.02038 0.8632 0.713151 0.591752 1.67855 GO:0046983 protein dimerization activity molecular_function Clostridium Clostridium thermocellum 4.03843 22.7861 16.3044 71.33 61.2833 62.8522 GO:0046983 protein dimerization activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.242554 0.556256 0.889407 0.37529 0.286609 0.599692 GO:0047001 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity molecular_function Escherichia Escherichia coli 1.43953 0 0 0 0 0 GO:0047017 prostaglandin-F synthase activity molecular_function Escherichia Escherichia coli 0.143394 0 0 0 0 0 GO:0047068 N5,N10-methenyltetrahydromethanopterin hydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.932547 1.73215 2.1757 2.31429 2.1895 5.72751 GO:0047111 formate dehydrogenase (cytochrome-c-553) activity molecular_function Escherichia Escherichia coli 0.0717456 0 0 0 0 0.0111569 GO:0047134 protein-disulfide reductase activity molecular_function Escherichia Escherichia coli 0.0314008 0 0 0 0 0 GO:0047138 aquacobalamin reductase activity molecular_function Escherichia Escherichia coli 0.086012 0 0.23753 0 0 0 GO:0047151 methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity molecular_function Clostridium Clostridium thermocellum 1.54783 8.23481 3.57378 33.2139 32.0653 25.7839 GO:0047151 methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 15.3952 25.0556 21.3114 16.3395 17.3561 16.2648 GO:0047154 methylmalonyl-CoA carboxytransferase activity molecular_function Clostridium Clostridium thermocellum 9.46407 45.2124 18.9764 191.309 126.004 123.774 GO:0047241 lipopolysaccharide N-acetylmannosaminouronosyltransferase activity molecular_function Escherichia Escherichia coli 0.0822449 0 0 0 0 0 GO:0047244 N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.405076 2.40616 2.02437 5.00743 5.81415 7.05007 GO:0047270 lipopolysaccharide glucosyltransferase II activity molecular_function Escherichia Escherichia coli 0.279254 0 0.0518272 0 0 0.148694 GO:0047294 phosphoglycerol geranylgeranyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.162837 0 0.37763 0.291528 0.327171 0.378915 GO:0047295 geranylgeranylglycerol-phosphate geranylgeranyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.10719 0.187014 0.092942 GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity molecular_function Escherichia Escherichia coli 0.0217764 0 0.079748 0 0 0 GO:0047310 glutamine-scyllo-inositol transaminase activity molecular_function Clostridium Clostridium thermocellum 0.21441 2.05887 0.309565 6.04406 8.5926 8.3998 GO:0047324 phosphoenolpyruvate-glycerone phosphotransferase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0350877 GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity molecular_function Clostridium Clostridium thermocellum 7.50242 63.6197 37.5005 278.781 233.258 164.662 GO:0047355 CDP-glycerol glycerophosphotransferase activity molecular_function Clostridium Clostridium thermocellum 0.0454972 0 0 0.0465569 0.0406062 0 GO:0047355 CDP-glycerol glycerophosphotransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.8887 25.5153 10.5777 19.2544 22.5056 21.648 GO:0047360 undecaprenyl-phosphate galactose phosphotransferase activity molecular_function Clostridium Clostridium thermocellum 3.31325 18.5234 21.8266 35.8816 36.2974 57.8469 GO:0047372 acylglycerol lipase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 130.308 180.976 306.722 127.162 177.056 100.76 GO:0047429 nucleoside-triphosphate diphosphatase activity molecular_function Clostridium Clostridium thermocellum 4.42378 27.4467 20.7349 59.5457 61.5965 71.5612 GO:0047429 nucleoside-triphosphate diphosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.9694 79.6803 76.3232 58.9659 71.4159 58.7156 GO:0047429 nucleoside-triphosphate diphosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.235117 0.564237 1.08797 0.960733 0.471539 1.87452 GO:0047440 2-dehydro-3-deoxy-D-pentonate aldolase activity molecular_function Escherichia Escherichia coli 0.0899007 0 0 0 0 0 GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity molecular_function Clostridium Clostridium thermocellum 2.00445 17.7779 12.3916 52.541 46.1825 72.3142 GO:0047451 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity molecular_function Escherichia Escherichia coli 0 0 0.294815 0 0 0 GO:0047475 phenylacetate-CoA ligase activity molecular_function Clostridium Clostridium thermocellum 7.14724 53.8933 41.7253 103.042 95.011 84.8779 GO:0047475 phenylacetate-CoA ligase activity molecular_function Escherichia Escherichia coli 0.0514031 0 0 0 0 0 GO:0047475 phenylacetate-CoA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.294541 0.161957 0.702937 0.517149 0.187709 0.47619 GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity molecular_function Clostridium Clostridium thermocellum 2.66061 18.9106 21.8839 51.6569 46.4233 52.6138 GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 93.6144 85.4518 89.3883 66.6686 70.5838 51.1285 GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity molecular_function Escherichia Escherichia coli 0.0401989 0 0 0 0 0 GO:0047480 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0623642 0.159577 0.0385659 0.127484 0.111271 0.0552672 GO:0047484 regulation of response to osmotic stress biological_process Escherichia Escherichia coli 0.0815887 0 0 0 0 0 GO:0047527 2,3-dihydroxybenzoate-serine ligase activity molecular_function Escherichia Escherichia coli 0 0 0.127425 0 0 0 GO:0047553 2-oxoglutarate synthase activity molecular_function Clostridium Clostridium thermocellum 10.2128 109.242 75.1143 275.178 259.948 203.582 GO:0047553 2-oxoglutarate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 61.2888 50.6646 77.3708 26.7822 35.8421 40.8824 GO:0047553 2-oxoglutarate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0984557 0.225854 0.251197 0.632696 0.527142 0.219355 GO:0047617 acyl-CoA hydrolase activity molecular_function Escherichia Escherichia coli 0.0976051 0 0 0 0 0 GO:0047631 ADP-ribose diphosphatase activity molecular_function Clostridium Clostridium thermocellum 3.0439600000000002 23.2511 19.2002 64.0822 62.3987 82.9162 GO:0047631 ADP-ribose diphosphatase activity molecular_function Escherichia Escherichia coli 0.101275 0 0 0 0 0 GO:0047693 ATP diphosphatase activity molecular_function Escherichia Escherichia coli 0.0150928 0 0 0 0 0 GO:0047760 butyrate-CoA ligase activity molecular_function Clostridium Clostridium thermocellum 2.00474 6.15989 3.39344 23.8122 21.0374 16.1112 GO:0047760 butyrate-CoA ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.215553 0.207418 0 0 0 0 GO:0047761 butyrate kinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 99.7304 47.3327 54.2261 18.4366 26.1416 51.9546 GO:0047850 diaminopimelate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 2.37006 16.0535 10.7892 47.5035 45.7581 47.6459 GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity molecular_function Clostridium Clostridium thermocellum 1.81461 8.36484 5.49274 33.4607 32.5297 24.5134 GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.221021 0.396106 0 0 GO:0048001 erythrose-4-phosphate dehydrogenase activity molecular_function Escherichia Escherichia coli 0.055875 0 0 0 0 0 GO:0048029 monosaccharide binding molecular_function Clostridium Clostridium thermocellum 8.9723 20.5811 17.6418 48.8933 48.7887 64.0767 GO:0048029 monosaccharide binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.691985 1.13095 2.00534 0.404388 0.791896 0.524763 GO:0048029 monosaccharide binding molecular_function Escherichia Escherichia coli 0.265789 0 0 0 0 0 GO:0048034 heme O biosynthetic process biological_process Escherichia Escherichia coli 0.0657425 0 0.122238 0 0 0 GO:0048037 cofactor binding molecular_function Clostridium Clostridium thermocellum 23.4304 122.456 112.408 309.517 238.34 368.942 GO:0048037 cofactor binding molecular_function Escherichia Escherichia coli 0.14772 0 0 0 0 0.114674 GO:0048037 cofactor binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.132895 0 0 0.0679452 0.118585 0 GO:0048038 quinone binding molecular_function Clostridium Clostridium thermocellum 0.783927 6.16806 3.72998 19.1628 18.519 16.1259 GO:0048038 quinone binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 114.64 130.538 140.443 157.122 149.942 80.4752 GO:0048038 quinone binding molecular_function Escherichia Escherichia coli 0.460367 0 0.579391 0 0 0.228183 GO:0048038 quinone binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.123683 0 0.181147 0.940688 0.628191 0.251338 GO:0048040 UDP-glucuronate decarboxylase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.0923797 0 0 0.0630458 0.0274976 0.0819791 GO:0048388 endosomal lumen acidification biological_process Clostridium Clostridium thermocellum 0.844128 1.36483 0.989498 14.7573 12.6659 10.6787 GO:0048388 endosomal lumen acidification biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0151414 0.116311 0.168608 0.123953 0.0946464 0.362616 GO:0048472 threonine-phosphate decarboxylase activity molecular_function Clostridium Clostridium thermocellum 1.31388 10.2492 9.35046 27.9337 25.8596 34.5376 GO:0048472 threonine-phosphate decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.228701 0.0627293 0.181869 0.0668509 0.0583808 0.434602 GO:0048473 D-methionine transport biological_process Escherichia Escherichia coli 0.291284 0 0.135454 0 0 0 GO:0048511 rhythmic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.62028 2.65867 0 0 0.824819 0 GO:0048870 cell motility biological_process Escherichia Escherichia coli 0 0 0.142987 0 0 0 GO:0050081 maltose-6'-phosphate glucosidase activity molecular_function Escherichia Escherichia coli 0.0207314 0 0.115382 0 0 0 GO:0050089 mannose isomerase activity molecular_function Escherichia Escherichia coli 0 0 0.0826348 0 0 0 GO:0050136 NADH dehydrogenase (quinone) activity molecular_function Clostridium Clostridium thermocellum 0.331191 4.92771 2.86822 9.38924 10.3754 12.6874 GO:0050163 oxaloacetate tautomerase activity molecular_function Escherichia Escherichia coli 0 0 0.06784 0 0 0.042752 GO:0050182 phosphate butyryltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 84.1331 96.2858 106.577 80.2442 97.0631 110.934 GO:0050225 pseudouridine kinase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.112378 GO:0050242 pyruvate, phosphate dikinase activity molecular_function Clostridium Clostridium thermocellum 2.59281 11.6392 13.25 49.2864 44.0848 41.199 GO:0050242 pyruvate, phosphate dikinase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 53.4174 54.7495 42.6241 62.2203 69.7192 37.1381 GO:0050263 ribosylpyrimidine nucleosidase activity molecular_function Escherichia Escherichia coli 0 0 0.0567438 0 0 0.040844 GO:0050270 S-adenosylhomocysteine deaminase activity molecular_function Clostridium Clostridium thermocellum 2.16138 9.32091 3.97432 40.4601 33.0883 28.9094 GO:0050270 S-adenosylhomocysteine deaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0428724 0 0.0795225 0 0 0.0570135 GO:0050297 stizolobate synthase activity molecular_function Escherichia Escherichia coli 0.109417 0 0 0 0 0 GO:0050308 sugar-phosphatase activity molecular_function Escherichia Escherichia coli 0.549369 0 0.318541 0 0 0.235589 GO:0050355 triphosphatase activity molecular_function Clostridium Clostridium thermocellum 0.295999 3.34197 2.52293 10.5247 8.16498 9.25041 GO:0050355 triphosphatase activity molecular_function Escherichia Escherichia coli 0.0421918 0 0 0 0 0 GO:0050380 undecaprenyl-diphosphatase activity molecular_function Clostridium Clostridium thermocellum 1.23491 9.13104 5.3175 27.0817 19.7135 23.0007 GO:0050380 undecaprenyl-diphosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 9.94741 5.0141 2.59939 7.62938 7.53182 5.54085 GO:0050380 undecaprenyl-diphosphatase activity molecular_function Escherichia Escherichia coli 0.0700686 0 0 0 0 0 GO:0050380 undecaprenyl-diphosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.281003 0.744397 0.263782 0.502426 0.109621 0 GO:0050418 hydroxylamine reductase activity molecular_function Clostridium Clostridium thermocellum 0.0657425 0 0 0.672563 0.58702 0.524666 GO:0050418 hydroxylamine reductase activity molecular_function Escherichia Escherichia coli 0 0 0.0600366 0 0 0 GO:0050418 hydroxylamine reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.642915 1.0699 0.954586 0.394565 0.344447 0.142582 GO:0050454 coenzyme F420 hydrogenase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 14.4802 5.58436 16.7493 14.0663 9.30224 8.95946 GO:0050462 N-acetylneuraminate synthase activity molecular_function Clostridium Clostridium thermocellum 2.01823 7.02629 4.44239 48.2055 36.2254 39.8759 GO:0050480 imidazolonepropionase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.62478 1.16768 3.34324 0.222239 0.523626 0.722321 GO:0050485 oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor molecular_function Coprothermobacter Coprothermobacter proteolyticus 42.2174 67.3724 100.564 54.2061 62.3147 39.6642 GO:0050492 glycerol-1-phosphate dehydrogenase [NAD(P)+] activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 26.9496 29.1195 18.9011 34.006100000000004 35.9212 26.0876 GO:0050492 glycerol-1-phosphate dehydrogenase [NAD(P)+] activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.652467 0.832564 0.908126 0.445101 0.145627 0.433826 GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.54379 8.55392 5.82296 31.9707 23.7419 22.9967 GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity molecular_function Escherichia Escherichia coli 0.0536877 0 0 0 0 0 GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity molecular_function Clostridium Clostridium thermocellum 0.848941 11.2061 6.29861 25.2185 22.7673 27.9916 GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.344656 4.62774 3.83869 11.3675 8.69026 9.27282 GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 21.76 21.9113 19.3042 21.3913 29.527 21.6888 GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity molecular_function Escherichia Escherichia coli 0.173288 0 0 0 0 0 GO:0050524 coenzyme-B sulfoethylthiotransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 13.3118 5.09979 12.4445 8.37245 5.00675 6.70278 GO:0050532 2-phosphosulfolactate phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 53.5065 48.6657 49.1516 34.1438 35.34 36.2278 GO:0050532 2-phosphosulfolactate phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.183082 0.614785 0.339786 0.655626 0.572045 0.426324 GO:0050545 sulfopyruvate decarboxylase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.497091 0.362934 0.552778 0.060509 0.212775 0 GO:0050560 aspartate-tRNA(Asn) ligase activity molecular_function Clostridium Clostridium thermocellum 3.08479 10.53 7.33533 31.6193 26.3966 21.6467 GO:0050560 aspartate-tRNA(Asn) ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0417544 0.0801853 0.154985 0.213386 0.0372856 0.138863 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function Clostridium Clostridium thermocellum 3.12545 15.906 14.9013 46.4618 52.7237 54.1587 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.7495 26.3112 22.9783 19.8318 22.7685 18.6935 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.846073 0.616558 0.66604 0.462137 0.606228 0.603799 GO:0050568 protein-glutamine glutaminase activity molecular_function Clostridium Clostridium thermocellum 2.16916 4.866 4.02655 38.4534 35.0295 26.73 GO:0050568 protein-glutamine glutaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.14981 0 0 0 0 0 GO:0050569 glycolaldehyde dehydrogenase activity molecular_function Escherichia Escherichia coli 0.0389594 0 0 0 0 0 GO:0050570 4-hydroxythreonine-4-phosphate dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 0.806992 4.3834 5.1142 9.48325 7.42947 10.5914 GO:0050570 4-hydroxythreonine-4-phosphate dehydrogenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 4.07375 7.12706 5.74208 2.3601 3.26514 4.11351 GO:0050572 L-idonate 5-dehydrogenase activity molecular_function Escherichia Escherichia coli 0.110219 0 0 0 0 0.0733446 GO:0050583 hydrogen dehydrogenase (NADP+) activity molecular_function Clostridium Clostridium thermocellum 0.799117 5.95667 2.0352 64.6092 63.8474 70.9831 GO:0050605 superoxide reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 100.946 67.9705 80.2931 72.2024 85.5126 89.8118 GO:0050605 superoxide reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.432564 2.69489 1.20285 0.665201 0.848041 0.717374 GO:0050660 flavin adenine dinucleotide binding molecular_function Clostridium Clostridium thermocellum 39.1212 295.226 284.114 849.572 733.461 667.203 GO:0050660 flavin adenine dinucleotide binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 131.205 138.242 96.7743 100.84 119.205 97.7285 GO:0050660 flavin adenine dinucleotide binding molecular_function Escherichia Escherichia coli 1.62823 0 1.70994 0 0 0.642768 GO:0050660 flavin adenine dinucleotide binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 15.6636 8.30235 19.3987 15.7627 10.4154 10.2382 GO:0050661 NADP binding molecular_function Clostridium Clostridium thermocellum 41.3139 386.441 261.994 1141.59 1195.07 1007.27 GO:0050661 NADP binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 72.6739 273.121 209.922 182.837 266.242 187.484 GO:0050661 NADP binding molecular_function Escherichia Escherichia coli 0.938355 0 0.495403 0 0 0.0260975 GO:0050661 NADP binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.35737 5.8061 5.53067 3.35175 1.88064 4.10507 GO:0050662 coenzyme binding molecular_function Clostridium Clostridium thermocellum 2.82547 21.2995 13.4876 47.656 36.4372 51.4067 GO:0050662 coenzyme binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 92.0826 136.758 127.533 110.318 134.967 120.803 GO:0050662 coenzyme binding molecular_function Escherichia Escherichia coli 0.143613 0 0.274968 0 0 0.0489934 GO:0050662 coenzyme binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.117777 0.494647 0.323593 0.566069 0.380669 0.389457 GO:0050782 galactose uniporter activity molecular_function Escherichia Escherichia coli 0.172097 0 0.109022 0 0 0 GO:0050797 thymidylate synthase (FAD) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 32.4181 24.5272 22.7811 26.6489 29.5605 19.1002 GO:0050821 protein stabilization biological_process Escherichia Escherichia coli 1.17768 0 0 0 0 0 GO:0050897 cobalt ion binding molecular_function Escherichia Escherichia coli 0.141523 0 0.180065 0 0 0.288431 GO:0050897 cobalt ion binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.06098 1.41622 6.55711 7.25927 8.9755 7.6095 GO:0050911 detection of chemical stimulus involved in sensory perception of smell biological_process Escherichia Escherichia coli 0.361523 0 0.379841 0 0 0.0899345 GO:0050919 negative chemotaxis biological_process Escherichia Escherichia coli 0.0341229 0 0 0 0 0 GO:0050983 deoxyhypusine biosynthetic process from spermidine biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.125603 0 0 0.28919 0 0.0417172 GO:0050992 dimethylallyl diphosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 10.7237 46.6363 29.7841 186.272 153.421 117.459 GO:0050992 dimethylallyl diphosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 1.63248 1.26724 0.451695 2.02813 2.76315 2.82221 GO:0050992 dimethylallyl diphosphate biosynthetic process biological_process Escherichia Escherichia coli 0.121836 0 0 0 0 0 GO:0051060 pullulanase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 71.8698 13.8513 20.8748 10.7321 12.5328 16.2434 GO:0051073 adenosylcobinamide-GDP ribazoletransferase activity molecular_function Clostridium Clostridium thermocellum 0.529245 6.25324 3.85109 14.4517 14.1 18.0306 GO:0051073 adenosylcobinamide-GDP ribazoletransferase activity molecular_function Escherichia Escherichia coli 0 0 0.151602 0 0 0 GO:0051073 adenosylcobinamide-GDP ribazoletransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0.225532 0.165809 0.0723358 0.215506 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity biological_process Escherichia Escherichia coli 0.201602 0 0.187552 0 0 0 GO:0051103 DNA ligation involved in DNA repair biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.110778 0.060769 0.117502 0.145714 0.0847716 0.126316 GO:0051108 carnitine-CoA ligase activity molecular_function Escherichia Escherichia coli 0.069704 0 0.0642766 0 0 0 GO:0051109 crotonobetaine-CoA ligase activity molecular_function Escherichia Escherichia coli 0.069704 0 0.0642766 0 0 0 GO:0051116 cobaltochelatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0293107 0.0187628 0.145017 0.0799574 0.0784994 0.12997 GO:0051156 glucose 6-phosphate metabolic process biological_process Escherichia Escherichia coli 0 0 0.404198 0 0 0 GO:0051186 cofactor metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 3.1352 1.82909 1.6582 6.13782 3.74195 5.20659 GO:0051188 cofactor biosynthetic process biological_process Clostridium Clostridium thermocellum 1.61352 22.1508 20.8666 38.4793 38.9153 60.6715 GO:0051188 cofactor biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 1.46276 2.28943 2.91662 0.637297 0.99204 1.80244 GO:0051205 protein insertion into membrane biological_process Clostridium Clostridium thermocellum 4.2142 27.8186 18.5678 87.6912 80.7945 71.4186 GO:0051205 protein insertion into membrane biological_process Coprothermobacter Coprothermobacter proteolyticus 11.9072 4.96719 2.44729 10.8778 13.9986 7.32919 GO:0051205 protein insertion into membrane biological_process Escherichia Escherichia coli 0.300082 0 0 0 0 0 GO:0051213 dioxygenase activity molecular_function Clostridium Clostridium thermocellum 0.372484 1.76534 1.72627 21.9498 17.421 12.2609 GO:0051213 dioxygenase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 89.9172 7.84009 9.02813 38.6527 46.3505 23.1125 GO:0051252 regulation of RNA metabolic process biological_process Escherichia Escherichia coli 0.0135617 0 0 0 0 0.0352171 GO:0051258 protein polymerization biological_process Clostridium Clostridium thermocellum 12.0632 81.9794 60.0784 204.496 182.774 233.796 GO:0051258 protein polymerization biological_process Coprothermobacter Coprothermobacter proteolyticus 43.0316 45.2198 45.1907 42.857 46.1551 35.4182 GO:0051258 protein polymerization biological_process Methanothermobacter Methanothermobacter thermautotrophicus 7.95292 10.0726 7.46988 3.24533 2.46094 4.63953 GO:0051259 protein oligomerization biological_process Clostridium Clostridium thermocellum 1.82297 13.1449 13.7533 31.2698 33.892 34.5316 GO:0051259 protein oligomerization biological_process Coprothermobacter Coprothermobacter proteolyticus 58.4295 48.081 48.318600000000004 16.422 24.8708 34.0323 GO:0051259 protein oligomerization biological_process Escherichia Escherichia coli 0.151439 0 0 0 0 0 GO:0051260 protein homooligomerization biological_process Escherichia Escherichia coli 0.0977023 0 0.0675693 0 0 0 GO:0051262 protein tetramerization biological_process Escherichia Escherichia coli 0 0 0.284125 0 0 0 GO:0051271 negative regulation of cellular component movement biological_process Escherichia Escherichia coli 0.103414 0 0 0 0 0 GO:0051276 chromosome organization biological_process Escherichia Escherichia coli 0.0836546 0 0 0 0 0 GO:0051287 NAD binding molecular_function Clostridium Clostridium thermocellum 70.0845 685.082 524.908 2108.29 1994.74 1701.91 GO:0051287 NAD binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 237.47 362.961 314.02 286.644 366.902 246.262 GO:0051287 NAD binding molecular_function Escherichia Escherichia coli 2.65395 0 0.577046 0 0 0.0636106 GO:0051287 NAD binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.7356 2.90945 3.58429 3.38559 1.68597 4.20761 GO:0051289 protein homotetramerization biological_process Clostridium Clostridium thermocellum 1.23664 9.73149 5.3981 27.9807 25.9851 38.4535 GO:0051289 protein homotetramerization biological_process Escherichia Escherichia coli 0.508951 0 0.531623 0 0 0.282998 GO:0051301 cell division biological_process Clostridium Clostridium thermocellum 93.0019 642.626 533.72 1554.86 1439.93 1619.37 GO:0051301 cell division biological_process Coprothermobacter Coprothermobacter proteolyticus 377.684 382.711 328.354 314.927 346.973 273.02 GO:0051301 cell division biological_process Escherichia Escherichia coli 1.81651 0 0.65968 0 0 0.727916 GO:0051301 cell division biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.110778 0.060769 0.117502 0.145714 0.0847716 0.126316 GO:0051302 regulation of cell division biological_process Clostridium Clostridium thermocellum 2.1843 6.72123 11.0618 36.7201 30.3302 29.292 GO:0051304 chromosome separation biological_process Clostridium Clostridium thermocellum 0.598098 2.71552 4.03521 9.00478 12.1324 10.1976 GO:0051345 positive regulation of hydrolase activity biological_process Escherichia Escherichia coli 0.10949 0 0 0 0 0 GO:0051391 tRNA acetylation biological_process Escherichia Escherichia coli 0 0 0.096708 0 0 0 GO:0051392 tRNA N-acetyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.096708 0 0 0 GO:0051409 response to nitrosative stress biological_process Escherichia Escherichia coli 0.0466881 0 0 0 0 0 GO:0051454 intracellular pH elevation biological_process Escherichia Escherichia coli 0.0229187 0 0 0 0 0 GO:0051536 iron-sulfur cluster binding molecular_function Clostridium Clostridium thermocellum 29.0619 366.197 283.429 750.452 678.288 667.201 GO:0051536 iron-sulfur cluster binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 846.461 519.291 520.828 308.785 377.676 285.903 GO:0051536 iron-sulfur cluster binding molecular_function Escherichia Escherichia coli 0.249554 0 0.110375 0 0 0.0593419 GO:0051536 iron-sulfur cluster binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 16.4062 13.9493 19.097 16.9624 11.5156 14.0864 GO:0051537 2 iron, 2 sulfur cluster binding molecular_function Clostridium Clostridium thermocellum 8.40638 157.22 119.713 352.273 335.739 391.002 GO:0051537 2 iron, 2 sulfur cluster binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 19.8887 51.5596 28.3769 26.604 56.1896 72.3144 GO:0051537 2 iron, 2 sulfur cluster binding molecular_function Escherichia Escherichia coli 0.790076 0 1.50975 0 0 0.0369957 GO:0051537 2 iron, 2 sulfur cluster binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 1.03183 3.62458 3.52966 6.10746 2.67274 5.49318 GO:0051538 3 iron, 4 sulfur cluster binding molecular_function Clostridium Clostridium thermocellum 10.7237 46.6363 29.7841 186.272 153.421 117.459 GO:0051538 3 iron, 4 sulfur cluster binding molecular_function Escherichia Escherichia coli 0.205151 0 0.0465498 0 0 0 GO:0051539 4 iron, 4 sulfur cluster binding molecular_function Clostridium Clostridium thermocellum 288.147 1830.98 1478.41 4777.71 4082.78 4764.19 GO:0051539 4 iron, 4 sulfur cluster binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 603.401 378.442 469.489 275.824 362.126 318.589 GO:0051539 4 iron, 4 sulfur cluster binding molecular_function Escherichia Escherichia coli 3.06032 0 1.89352 0 0 0.607421 GO:0051539 4 iron, 4 sulfur cluster binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 10.8238 20.2126 20.4974 26.843 14.6219 21.6572 GO:0051575 5'-deoxyribose-5-phosphate lyase activity molecular_function Escherichia Escherichia coli 0 0 0.0705914 0 0 0 GO:0051595 response to methylglyoxal biological_process Escherichia Escherichia coli 0.298308 0 0.266082 0 0 0.0856334 GO:0051603 proteolysis involved in cellular protein catabolic process biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0846632 GO:0051604 protein maturation biological_process Escherichia Escherichia coli 0.111629 0 0.117006 0 0 0.0375455 GO:0051606 detection of stimulus biological_process Clostridium Clostridium thermocellum 4.93358 18.9337 16.2534 63.1571 73.0955 145.364 GO:0051607 defense response to virus biological_process Clostridium Clostridium thermocellum 8.10355 3.93972 1.40096 17.8139 13.038 20.0466 GO:0051607 defense response to virus biological_process Coprothermobacter Coprothermobacter proteolyticus 5.5248 2.45653 1.18021 1.52713 3.02595 2.5506 GO:0051607 defense response to virus biological_process Escherichia Escherichia coli 0.699349 0 0.795856 0 0 0.0697873 GO:0051607 defense response to virus biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.814623 0.797092 1.12509 0.367456 1.15134 0.865938 GO:0051692 cellular oligosaccharide catabolic process biological_process Escherichia Escherichia coli 0.104191 0 0.0487149 0 0 0 GO:0051726 regulation of cell cycle biological_process Clostridium Clostridium thermocellum 2.1843 6.72123 11.0618 36.7201 30.3302 29.292 GO:0051745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity molecular_function Clostridium Clostridium thermocellum 10.7237 46.6363 29.7841 186.272 153.421 117.459 GO:0051745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.63248 1.26724 0.451695 2.02813 2.76315 2.82221 GO:0051775 response to redox state biological_process Clostridium Clostridium thermocellum 2.40763 14.705 10.6371 34.7976 28.0143 40.7787 GO:0051775 response to redox state biological_process Coprothermobacter Coprothermobacter proteolyticus 18.0234 42.4295 43.0026 32.0197 37.1684 34.5454 GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity molecular_function Escherichia Escherichia coli 0 0 0.0939565 0 0 0.0336971 GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity molecular_function Escherichia Escherichia coli 0.0198321 0 0 0 0 0 GO:0051912 CoB--CoM heterodisulfide reductase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 4.45484 3.66033 3.96183 9.47997 5.81855 8.38619 GO:0051920 peroxiredoxin activity molecular_function Clostridium Clostridium thermocellum 16.6655 197.62 147.526 503.683 345.685 656.368 GO:0051920 peroxiredoxin activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 245.438 538.765 456.814 334.051 461.701 429.056 GO:0051920 peroxiredoxin activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.657255 2.56686 1.64981 0.267901 0.466917 0.631417 GO:0051978 lysophospholipid transporter activity molecular_function Escherichia Escherichia coli 0.0231618 0 0.0432119 0 0 0.0610558 GO:0051989 coproporphyrinogen dehydrogenase activity molecular_function Clostridium Clostridium thermocellum 0.562736 5.12201 2.95248 9.71208 10.8358 8.56095 GO:0051989 coproporphyrinogen dehydrogenase activity molecular_function Escherichia Escherichia coli 0 0 0.0368519 0 0 0 GO:0051991 UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity molecular_function Clostridium Clostridium thermocellum 1.54379 8.55392 5.82296 31.9707 23.7419 22.9967 GO:0051991 UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity molecular_function Escherichia Escherichia coli 0.0536877 0 0 0 0 0 GO:0051992 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity molecular_function Clostridium Clostridium thermocellum 3.48304 21.2983 23.8072 68.5512 55.4425 61.7905 GO:0051992 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 102.047 48.8863 42.9468 45.5351 37.9895 28.5499 GO:0051992 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0536634 0 0 0.0549132 0 0.142776 GO:0052131 positive aerotaxis biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0235751 GO:0052381 tRNA dimethylallyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.42358 5.89156 6.37795 27.6865 30.4344 39.958 GO:0052381 tRNA dimethylallyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 3.11746 2.41849 1.54029 1.40437 1.32917 1.29456 GO:0052381 tRNA dimethylallyltransferase activity molecular_function Escherichia Escherichia coli 0.0606386 0 0 0 0 0 GO:0052547 regulation of peptidase activity biological_process Clostridium Clostridium thermocellum 1.07971 2.46217 0.685887 10.4612 7.32033 7.00399 GO:0052591 sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity molecular_function Escherichia Escherichia coli 0.0716727 0 0.0664868 0 0 0 GO:0052618 coenzyme F420-0:L-glutamate ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.159629 0.229914 0.147994 0.366486 0.14248 0.265502 GO:0052619 coenzyme F420-1:gamma-L-glutamate ligase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.159629 0.229914 0.147994 0.366486 0.14248 0.265502 GO:0052621 diguanylate cyclase activity molecular_function Escherichia Escherichia coli 0.131169 0 0.0671634 0 0 0.122855 GO:0052645 F420-0 metabolic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.420703 0.818608 0.96072 0.724417 0.181523 0.440326 GO:0052653 3',5'-cyclic diguanylic acid metabolic process biological_process Escherichia Escherichia coli 0.0269046 0 0.049932699999999997 0 0 0 GO:0052654 L-leucine transaminase activity molecular_function Clostridium Clostridium thermocellum 2.90122 27.9123 17.6762 74.296 70.4999 72.3582 GO:0052654 L-leucine transaminase activity molecular_function Escherichia Escherichia coli 0 0 0.115427 0 0 0.0414585 GO:0052654 L-leucine transaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.442746 0.534826 0.58977 0.205071 0.306767 GO:0052655 L-valine transaminase activity molecular_function Clostridium Clostridium thermocellum 2.90122 27.9123 17.6762 74.296 70.4999 72.3582 GO:0052655 L-valine transaminase activity molecular_function Escherichia Escherichia coli 0 0 0.115427 0 0 0.0414585 GO:0052655 L-valine transaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.442746 0.534826 0.58977 0.205071 0.306767 GO:0052656 L-isoleucine transaminase activity molecular_function Clostridium Clostridium thermocellum 2.90122 27.9123 17.6762 74.296 70.4999 72.3582 GO:0052656 L-isoleucine transaminase activity molecular_function Escherichia Escherichia coli 0 0 0.115427 0 0 0.0414585 GO:0052656 L-isoleucine transaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.442746 0.534826 0.58977 0.205071 0.306767 GO:0052657 guanine phosphoribosyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 8.76042 9.12357 11.0711 12.0851 15.1185 13.2017 GO:0052657 guanine phosphoribosyltransferase activity molecular_function Escherichia Escherichia coli 0.125603 0 0.23311 0 0 0.309904 GO:0052657 guanine phosphoribosyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.634761 0.307761 0.0564054 0.0984227 0 GO:0052665 tRNA (uracil-2'-O-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0862065 0 0 0 0 0 GO:0052666 tRNA (cytosine-2'-O-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0862065 0 0 0 0 0 GO:0052689 carboxylic ester hydrolase activity molecular_function Clostridium Clostridium thermocellum 0.0806165 0.619079 0.298965 0.988637 0.827684 0.858533 GO:0052689 carboxylic ester hydrolase activity molecular_function Escherichia Escherichia coli 0.52261 0 0.222735 0 0 0.0798124 GO:0052692 raffinose alpha-galactosidase activity molecular_function Escherichia Escherichia coli 0.0402961 0 0 0 0 0 GO:0052693 epoxyqueuosine reductase activity molecular_function Escherichia Escherichia coli 0 0 0.182185 0 0 0 GO:0052717 tRNA-specific adenosine-34 deaminase activity molecular_function Clostridium Clostridium thermocellum 4.98695 33.4582 24.2697 95.8039 74.3148 108.515 GO:0052717 tRNA-specific adenosine-34 deaminase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.08128 3.25926 2.86254 0.867992 1.23995 2.77157 GO:0052717 tRNA-specific adenosine-34 deaminase activity molecular_function Escherichia Escherichia coli 0.068659 0 0 0 0 0 GO:0052733 quinate 3-dehydrogenase (NADP+) activity molecular_function Escherichia Escherichia coli 0.0327619 0 0 0 0 0 GO:0052734 shikimate 3-dehydrogenase (NAD+) activity molecular_function Escherichia Escherichia coli 0.0327619 0 0 0 0 0 GO:0052737 pyruvate dehydrogenase (quinone) activity molecular_function Escherichia Escherichia coli 0.046445 0 0 0 0 0 GO:0052832 inositol monophosphate 3-phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 37.3761 42.5571 34.4422 32.5891 40.4493 39.8263 GO:0052832 inositol monophosphate 3-phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.27587 0 0 0 GO:0052832 inositol monophosphate 3-phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0701415 0.06735 0.260354 0.0717752 0.156587 0 GO:0052833 inositol monophosphate 4-phosphatase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 37.3761 42.5571 34.4422 32.5891 40.4493 39.8263 GO:0052833 inositol monophosphate 4-phosphatase activity molecular_function Escherichia Escherichia coli 0 0 0.27587 0 0 0 GO:0052833 inositol monophosphate 4-phosphatase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0701415 0.06735 0.260354 0.0717752 0.156587 0 GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity molecular_function Clostridium Clostridium thermocellum 2.71029 21.5149 19.8022 58.2358 63.1596 61.3673 GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 41.9319 35.3397 35.2756 29.3285 37.2414 29.4029 GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity molecular_function Escherichia Escherichia coli 0.0351437 0 0 0 0 0 GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0861822 0.0661832 0.191928 0.0705068 0.0615712 0.16053 GO:0052856 NADHX epimerase activity molecular_function Escherichia Escherichia coli 0.0351437 0 0 0 0 0 GO:0052857 NADPHX epimerase activity molecular_function Escherichia Escherichia coli 0.0351437 0 0 0 0 0 GO:0052865 1-deoxy-D-xylulose 5-phosphate biosynthetic process biological_process Clostridium Clostridium thermocellum 2.50876 20.0741 11.6512 48.092 46.587 44.3945 GO:0052865 1-deoxy-D-xylulose 5-phosphate biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 58.509 41.4332 32.2915 34.7667 42.3967 30.6407 GO:0052875 riboflavin reductase (NADH) activity molecular_function Escherichia Escherichia coli 0.086012 0 0.23753 0 0 0 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor molecular_function Escherichia Escherichia coli 0.065864 0 0.0611642 0 0 0 GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.67734 8.31579 3.26426 21.8374 22.1119 21.0588 GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.937 22.5368 17.8595 24.4585 29.2359 18.1588 GO:0052906 tRNA (guanine(37)-N(1))-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0830956 0 0.43699 0 0 0 GO:0052908 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.480005 3.09628 2.75081 11.3416 10.0213 10.6301 GO:0052908 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 11.0203 9.38784 6.66771 7.82058 9.52142 8.62006 GO:0052911 23S rRNA (guanine(745)-N(1))-methyltransferase activity molecular_function Escherichia Escherichia coli 0.151123 0 0 0 0 0 GO:0052913 16S rRNA (guanine(966)-N(2))-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.826678 3.28045 1.94336 12.8537 9.63987 16.2693 GO:0052914 16S rRNA (guanine(1207)-N(2))-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0551216 0 0 0 0 0 GO:0052915 23S rRNA (guanine(2445)-N(2))-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0247901 0 0 0 0 0 GO:0052916 23S rRNA (guanine(1835)-N(2))-methyltransferase activity molecular_function Escherichia Escherichia coli 0.04924 0 0.0913855 0 0 0 GO:0052927 CTP:tRNA cytidylyltransferase activity molecular_function Escherichia Escherichia coli 0.0223111 0 0 0 0 0 GO:0052927 CTP:tRNA cytidylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.15365 0.0742451 0.0614043 0.0178615 0 GO:0052928 CTP:3'-cytidine-tRNA cytidylyltransferase activity molecular_function Escherichia Escherichia coli 0.0223111 0 0 0 0 0 GO:0052928 CTP:3'-cytidine-tRNA cytidylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.15365 0.0742451 0.0614043 0.0178615 0 GO:0052929 ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity molecular_function Escherichia Escherichia coli 0.0223111 0 0 0 0 0 GO:0052929 ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.15365 0.0742451 0.0614043 0.0178615 0 GO:0055062 phosphate ion homeostasis biological_process Escherichia Escherichia coli 0.0724747 0 0 0 0 0 GO:0055070 copper ion homeostasis biological_process Escherichia Escherichia coli 0.0418759 0 0 0 0 0 GO:0055072 iron ion homeostasis biological_process Clostridium Clostridium thermocellum 0 0 0 0.0248701 0.0976414 0.048476 GO:0055072 iron ion homeostasis biological_process Coprothermobacter Coprothermobacter proteolyticus 6.08462 5.46879 4.18758 3.62868 3.38264 2.09136 GO:0055072 iron ion homeostasis biological_process Escherichia Escherichia coli 0.488852 0 0.713447 0 0 0.115806 GO:0055085 transmembrane transport biological_process Clostridium Clostridium thermocellum 10.823 32.2052 22.3919 176.205 153.093 89.4269 GO:0055085 transmembrane transport biological_process Coprothermobacter Coprothermobacter proteolyticus 327.662 173.635 163.847 180.746 200.23 135.771 GO:0055085 transmembrane transport biological_process Escherichia Escherichia coli 4.98622 0 3.56746 0 0 1.42055 GO:0055085 transmembrane transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.37418 1.60982 2.05965 3.62462 2.23375 1.89839 GO:0055088 lipid homeostasis biological_process Escherichia Escherichia coli 0.065864 0 0.0611642 0 0 0 GO:0055114 oxidation-reduction process biological_process Clostridium Clostridium thermocellum 194.097 2022.24 1047.27 6376.18 4231.67 7954.78 GO:0055114 oxidation-reduction process biological_process Coprothermobacter Coprothermobacter proteolyticus 25.4756 25.6189 24.403 11.5876 15.8201 15.0285 GO:0055114 oxidation-reduction process biological_process Escherichia Escherichia coli 1.07891 0 2.3085 0 0 0.127642 GO:0055114 oxidation-reduction process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 1.96396 14.9282 6.80542 3.85818 1.87576 6.44889 GO:0055129 L-proline biosynthetic process biological_process Clostridium Clostridium thermocellum 13.6731 70.1336 52.7249 157.35 138.219 140.283 GO:0060698 endoribonuclease inhibitor activity molecular_function Escherichia Escherichia coli 0.260807 0 0 0 0 0 GO:0061077 chaperone-mediated protein folding biological_process Escherichia Escherichia coli 1.00381 0 0.704742 0 0 0.13909 GO:0061489 guanine import into cell biological_process Escherichia Escherichia coli 0.0803249 0 0 0 0 0.0530681 GO:0061593 sulfoquinovose isomerase activity molecular_function Escherichia Escherichia coli 0 0 0.0826348 0 0 0 GO:0061594 6-deoxy-6-sulfofructose kinase activity molecular_function Escherichia Escherichia coli 0.065062 0 0 0 0 0 GO:0061595 6-deoxy-6-sulfofructose-1-phosphate aldolase activity molecular_function Escherichia Escherichia coli 0.066666 0 0 0 0 0 GO:0061596 3-sulfolactaldehyde reductase activity molecular_function Escherichia Escherichia coli 0.0303315 0 0 0 0 0 GO:0061597 cyclic pyranopterin monophosphate synthase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 95.0111 26.1848 26.6875 16.0023 22.5185 15.4066 GO:0061597 cyclic pyranopterin monophosphate synthase activity molecular_function Escherichia Escherichia coli 0.057868 0 0 0 0 0 GO:0061597 cyclic pyranopterin monophosphate synthase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.303388 0.349632 0.225036 0.589571 0.216899 0.685681 GO:0061599 molybdopterin molybdotransferase activity molecular_function Escherichia Escherichia coli 0.0447681 0 0 0 0 0 GO:0061602 molybdenum cofactor cytidylyltransferase activity molecular_function Escherichia Escherichia coli 0.169958 0 0.210286 0 0 0 GO:0061603 molybdenum cofactor guanylyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0743471 GO:0061603 molybdenum cofactor guanylyltransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.372502 0 0.303291 0 0.065745 GO:0061634 alpha-D-xyloside xylohydrolase molecular_function Escherichia Escherichia coli 0.0112042 0 0.109744 0 0 0 GO:0061710 L-threonylcarbamoyladenylate synthase molecular_function Clostridium Clostridium thermocellum 2.60104 14.9827 12.0892 30.5973 35.1039 40.2446 GO:0061710 L-threonylcarbamoyladenylate synthase molecular_function Coprothermobacter Coprothermobacter proteolyticus 2.76653 6.19433 3.21126 2.47634 1.9306 2.07118 GO:0061710 L-threonylcarbamoyladenylate synthase molecular_function Escherichia Escherichia coli 0.11491 0 0 0 0 0 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase molecular_function Clostridium Clostridium thermocellum 1.08943 15.2844 12.2832 27.7742 29.4735 31.8847 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase molecular_function Coprothermobacter Coprothermobacter proteolyticus 14.8289 7.57256 9.17675 5.33897 6.41807 10.4873 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase molecular_function Escherichia Escherichia coli 0.0562639 0 0 0 0 0 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.116927 0.192435 0.0620212 0.136711 0.178984 0.0888996 GO:0061712 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.124479 0.240552 0.0442191 0 0.229186 GO:0065002 intracellular protein transmembrane transport biological_process Clostridium Clostridium thermocellum 15.2639 39.6753 26.2876 208.83 146.464 110.982 GO:0065002 intracellular protein transmembrane transport biological_process Coprothermobacter Coprothermobacter proteolyticus 103.649 85.5668 97.0939 74.2249 89.538 73.691 GO:0065002 intracellular protein transmembrane transport biological_process Escherichia Escherichia coli 0.130464 0 0.283087 0 0 0.0273587 GO:0065002 intracellular protein transmembrane transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.479884 0.348138 0.905871 0.768238 0.663957 0.866585 GO:0070006 metalloaminopeptidase activity molecular_function Clostridium Clostridium thermocellum 8.05568 14.5777 9.44085 114.135 72.6202 68.1519 GO:0070006 metalloaminopeptidase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 36.2657 12.3271 7.96299 13.5957 15.1914 12.7792 GO:0070006 metalloaminopeptidase activity molecular_function Escherichia Escherichia coli 0 0 0.139965 0 0 0 GO:0070006 metalloaminopeptidase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0648189 0.248864 0.420978 0.862173 0.28917 0.172463 GO:0070008 serine-type exopeptidase activity molecular_function Escherichia Escherichia coli 0.0127353 0 0 0 0 0 GO:0070011 peptidase activity, acting on L-amino acid peptides molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0547174 GO:0070038 rRNA (pseudouridine-N3-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 2.94551 26.2976 22.5284 68.8634 60.7609 81.1661 GO:0070038 rRNA (pseudouridine-N3-)-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.344 48.6971 24.3665 16.1115 22.4702 17.825 GO:0070039 rRNA (guanosine-2'-O-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.0835087 0 0 0 0 0 GO:0070040 rRNA (adenine-C2-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 1.7819 11.4019 8.76191 33.2804 31.5624 33.2572 GO:0070041 rRNA (uridine-C5-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.0773123 0 0 0 GO:0070043 rRNA (guanine-N7-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 0.0839462 3.13698 3.18419 13.7784 10.109 6.86629 GO:0070043 rRNA (guanine-N7-)-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 10.8064 4.82642 7.18093 6.27677 8.21336 3.74494 GO:0070043 rRNA (guanine-N7-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0.127353 0 0 0 0 0 GO:0070084 protein initiator methionine removal biological_process Clostridium Clostridium thermocellum 8.05568 14.5777 9.44085 114.135 72.6202 68.1519 GO:0070084 protein initiator methionine removal biological_process Coprothermobacter Coprothermobacter proteolyticus 36.2657 12.3271 7.96299 13.5957 15.1914 12.7792 GO:0070084 protein initiator methionine removal biological_process Escherichia Escherichia coli 0 0 0.139965 0 0 0 GO:0070084 protein initiator methionine removal biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0648189 0.248864 0.420978 0.862173 0.28917 0.172463 GO:0070125 mitochondrial translational elongation biological_process Escherichia Escherichia coli 0.0469554 0 0 0 0 0 GO:0070180 large ribosomal subunit rRNA binding molecular_function Clostridium Clostridium thermocellum 42.5327 96.4747 46.0233 629.277 477.498 339.832 GO:0070180 large ribosomal subunit rRNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 72.3708 84.5407 72.6907 93.2416 126.52 113.958 GO:0070180 large ribosomal subunit rRNA binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 2.82992 3.35387 5.81164 8.00151 3.70547 7.43319 GO:0070181 small ribosomal subunit rRNA binding molecular_function Clostridium Clostridium thermocellum 4.53786 13.9793 13.3934 45.292 45.279 39.6576 GO:0070181 small ribosomal subunit rRNA binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 16.9989 10.1952 10.9968 12.2321 13.6259 11.1628 GO:0070301 cellular response to hydrogen peroxide biological_process Escherichia Escherichia coli 0.0263456 0 0.0546689 0 0 0.070046 GO:0070402 NADPH binding molecular_function Clostridium Clostridium thermocellum 1.5856 8.00737 3.75655 20.4672 19.2295 15.9648 GO:0070402 NADPH binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 4.67053 4.78465 2.16822 5.04796 4.35649 2.48715 GO:0070402 NADPH binding molecular_function Escherichia Escherichia coli 0.0464207 0 0 0 0 0.24639 GO:0070402 NADPH binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0 0 0.440599 0 0.071857 GO:0070403 NAD+ binding molecular_function Clostridium Clostridium thermocellum 6.95135 45.9196 41.1006 72.7585 83.0025 129.835 GO:0070403 NAD+ binding molecular_function Coprothermobacter Coprothermobacter proteolyticus 39.0074 73.6862 90.1666 38.8953 49.7602 41.129 GO:0070403 NAD+ binding molecular_function Escherichia Escherichia coli 0.0402961 0 0 0 0 0 GO:0070417 cellular response to cold biological_process Escherichia Escherichia coli 0.0285816 0 0 0 0 0.0380952 GO:0070453 regulation of heme biosynthetic process biological_process Escherichia Escherichia coli 0 0 0.0573753 0 0 0 GO:0070475 rRNA base methylation biological_process Clostridium Clostridium thermocellum 35.1663 237.713 263.565 597.064 572.21 797.742 GO:0070475 rRNA base methylation biological_process Coprothermobacter Coprothermobacter proteolyticus 125.45 139.18 167.218 58.9941 68.6063 50.3356 GO:0070475 rRNA base methylation biological_process Escherichia Escherichia coli 0.151123 0 0 0 0 0 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.250124 0.192875 0.0532718 0.0465311 0.138637 GO:0070491 repressing transcription factor binding molecular_function Escherichia Escherichia coli 0.0457645 0 0 0 0 0.0304632 GO:0070574 cadmium ion transmembrane transport biological_process Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0070581 rolling circle DNA replication biological_process Escherichia Escherichia coli 0.0241582 0 0 0 0 0 GO:0070588 calcium ion transmembrane transport biological_process Escherichia Escherichia coli 0.0880536 0 0 0 0 0 GO:0070590 spore wall biogenesis biological_process Clostridium Clostridium thermocellum 0.109733 0.31598 0.33938 1.38467 1.63286 1.58095 GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 4.73713 3.81776 2.90485 3.76601 3.22935 2.67336 GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity molecular_function Escherichia Escherichia coli 0.03981 0 0 0 0 0 GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.121496 0.350005 0.563694 0.559503 0.14465 0.107786 GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 3.29626 6.52502 3.96548 21.0496 18.4026 15.9098 GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 1.04605 1.09856 0.176907 1.79801 1.31821 0.824318 GO:0070677 rRNA (cytosine-2'-O-)-methyltransferase activity molecular_function Escherichia Escherichia coli 0 0 0.126794 0 0 0 GO:0070689 L-threonine catabolic process to propionate biological_process Escherichia Escherichia coli 0.387941 0 0.127967 0 0 0 GO:0070814 hydrogen sulfide biosynthetic process biological_process Clostridium Clostridium thermocellum 0.170566 28.8948 17.7178 62.1958 54.7957 58.7528 GO:0070814 hydrogen sulfide biosynthetic process biological_process Escherichia Escherichia coli 0.405683 0 0 0 0 0 GO:0070929 trans-translation biological_process Clostridium Clostridium thermocellum 4.47212 48.2579 43.9077 95.8748 84.4923 122.216 GO:0070929 trans-translation biological_process Coprothermobacter Coprothermobacter proteolyticus 75.2413 70.2379 87.0147 49.5934 62.1343 41.7394 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.250124 0.192875 0.0532718 0.0465311 0.138637 GO:0070967 coenzyme F420 binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0 0.339924 0.246461 0 0.276647 0.0588891 GO:0070981 L-asparagine biosynthetic process biological_process Clostridium Clostridium thermocellum 2.00423 11.0108 9.29827 27.4214 27.3095 32.9501 GO:0070981 L-asparagine biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 9.43158 29.0199 18.8658 23.913 24.1686 9.43613 GO:0071025 RNA surveillance biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.250124 0.192875 0.0532718 0.0465311 0.138637 GO:0071111 cyclic-guanylate-specific phosphodiesterase activity molecular_function Escherichia Escherichia coli 0.543366 0 0.395628 0 0 0.189344 GO:0071249 cellular response to nitrate biological_process Escherichia Escherichia coli 0.0463478 0 0 0 0 0 GO:0071250 cellular response to nitrite biological_process Escherichia Escherichia coli 0.0463478 0 0 0 0 0 GO:0071266 'de novo' L-methionine biosynthetic process biological_process Clostridium Clostridium thermocellum 2.11693 7.52813 8.59258 20.3668 24.8744 25.0777 GO:0071266 'de novo' L-methionine biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.244572 0.104409 0.756839 0.862297 0.194176 0.506492 GO:0071271 1-butanol biosynthetic process biological_process Escherichia Escherichia coli 0.0471013 0 0 0 0 0.0626728 GO:0071310 cellular response to organic substance biological_process Escherichia Escherichia coli 0.158827 0 0.0597659 0 0 0 GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity molecular_function Clostridium Clostridium thermocellum 33.3844 226.311 254.804 563.783 540.647 764.485 GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 125.45 139.18 167.218 58.9941 68.6063 50.3356 GO:0071436 sodium ion export biological_process Clostridium Clostridium thermocellum 2.38104 17.75 13.8523 29.105 39.5093 53.9613 GO:0071436 sodium ion export biological_process Coprothermobacter Coprothermobacter proteolyticus 57.6596 26.7981 29.3111 17.74 17.493 12.5063 GO:0071436 sodium ion export biological_process Escherichia Escherichia coli 0.111993 0 0 0 0 0 GO:0071454 cellular response to anoxia biological_process Escherichia Escherichia coli 0.0263456 0 0.0546689 0 0 0.070046 GO:0071468 cellular response to acidic pH biological_process Escherichia Escherichia coli 0 0 0.246461 0 0 0 GO:0071470 cellular response to osmotic stress biological_process Escherichia Escherichia coli 0.132797 0 0 0 0 0.0773546 GO:0071474 cellular hyperosmotic response biological_process Escherichia Escherichia coli 0.0972162 0 0.180425 0 0 0 GO:0071555 cell wall organization biological_process Clostridium Clostridium thermocellum 83.1564 304.364 272.41 761.72 699.107 771.248 GO:0071555 cell wall organization biological_process Coprothermobacter Coprothermobacter proteolyticus 260.398 247.371 193.464 222.784 238.3 185.998 GO:0071555 cell wall organization biological_process Escherichia Escherichia coli 2.93117 0 1.80782 0 0 0.640666 GO:0071577 zinc II ion transmembrane transport biological_process Escherichia Escherichia coli 0.0237208 0 0.0220119 0 0 0 GO:0071705 nitrogen compound transport biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0946559 GO:0071713 para-aminobenzoyl-glutamate hydrolase activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0557199 GO:0071805 potassium ion transmembrane transport biological_process Escherichia Escherichia coli 0.207289 0 0 0 0 0 GO:0071897 DNA biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 18.8045 14.4913 14.601 13.952 18.8738 12.0016 GO:0071897 DNA biosynthetic process biological_process Escherichia Escherichia coli 0.0145824 0 0 0 0 0.0194033 GO:0071897 DNA biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.110778 0.060769 0.117502 0.145714 0.0847716 0.126316 GO:0071916 dipeptide transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.217035 0 0 0 0 0.0780984 GO:0071949 FAD binding molecular_function Escherichia Escherichia coli 0.250016 0 0.646329 0 0 0.0304632 GO:0071949 FAD binding molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0465666 0.894313 0.691345 1.16711 0.852447 1.11433 GO:0071963 establishment or maintenance of cell polarity regulating cell shape biological_process Escherichia Escherichia coli 0.0255679 0 0 0 0 0 GO:0071972 peptidoglycan L,D-transpeptidase activity molecular_function Escherichia Escherichia coli 0.0143151 0 0 0 0 0 GO:0071973 bacterial-type flagellum-dependent cell motility biological_process Clostridium Clostridium thermocellum 56.1354 142.275 107.883 1459.48 1423.45 1202.2 GO:0071973 bacterial-type flagellum-dependent cell motility biological_process Coprothermobacter Coprothermobacter proteolyticus 0.0268317 0 0 0 0 0 GO:0071973 bacterial-type flagellum-dependent cell motility biological_process Escherichia Escherichia coli 0.291211 0 0.439426 0 0 0.108982 GO:0071978 bacterial-type flagellum-dependent swarming motility biological_process Escherichia Escherichia coli 0.687416 0 0 0 0 0 GO:0072344 rescue of stalled ribosome biological_process Escherichia Escherichia coli 0.188405 0 0 0 0 0 GO:0072348 sulfur compound transport biological_process Escherichia Escherichia coli 0.300422 0 0 0 0 0 GO:0072531 pyrimidine-containing compound transmembrane transport biological_process Escherichia Escherichia coli 0.0219952 0 0 0 0 0.0584364 GO:0072592 oxygen metabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 5102.29 13939.3 11938.1 4792.25 5139.37 6668.11 GO:0075713 establishment of integrated proviral latency biological_process Escherichia Escherichia coli 0.380626 0 0.0852059 0 0 0.155097 GO:0080100 L-glutamine:2-oxoglutarate aminotransferase activity molecular_function Clostridium Clostridium thermocellum 0.21441 2.05887 0.309565 6.04406 8.5926 8.3998 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function Clostridium Clostridium thermocellum 4.86485 17.4735 15.7327 60.4082 63.6561 96.8323 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 50.0765 13.7323 32.6144 4.60319 5.75173 6.46044 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function Escherichia Escherichia coli 0.142932 0 0 0 0 0 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.12485 0.0956809 0.138792 0.765801 0.267575 0.0995068 GO:0080146 L-cysteine desulfhydrase activity molecular_function Escherichia Escherichia coli 0 0 0.0854314 0 0 0 GO:0080167 response to karrikin biological_process Coprothermobacter Coprothermobacter proteolyticus 15.1719 14.9984 15.1648 10.3004 13.3047 12.0245 GO:0080176 xyloglucan 1,6-alpha-xylosidase activity molecular_function Escherichia Escherichia coli 0.0112042 0 0.109744 0 0 0 GO:0089714 UDP-N-acetyl-D-mannosamine dehydrogenase activity molecular_function Escherichia Escherichia coli 0.130999 0 0.0405055 0 0 0 GO:0090071 negative regulation of ribosome biogenesis biological_process Clostridium Clostridium thermocellum 1.39243 22.0746 15.9619 51.3402 47.5091 73.1241 GO:0090071 negative regulation of ribosome biogenesis biological_process Coprothermobacter Coprothermobacter proteolyticus 4.65391 2.99453 3.27865 1.59564 2.6893 3.31622 GO:0090305 nucleic acid phosphodiester bond hydrolysis biological_process Escherichia Escherichia coli 0.206973 0 0.232208 0 0 0.0883498 GO:0090313 regulation of protein targeting to membrane biological_process Escherichia Escherichia coli 0.0142665 0 0 0 0 0 GO:0090501 RNA phosphodiester bond hydrolysis biological_process Escherichia Escherichia coli 0.0369908 0 0 0 0 0 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic biological_process Escherichia Escherichia coli 1.1593 0 0 0 0 0 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic biological_process Escherichia Escherichia coli 0 0 0.187146 0 0 0.0883498 GO:0090540 bacterial cellulose biosynthetic process biological_process Escherichia Escherichia coli 1.24636 0 0 0 0 0 GO:0090582 protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity molecular_function Escherichia Escherichia coli 0 0 0 0 0 0.0209879 GO:0090589 protein-phosphocysteine-trehalose phosphotransferase system transporter activity molecular_function Escherichia Escherichia coli 0.0383275 0 0 0 0 0.0431401 GO:0090613 5'-deoxyadenosine deaminase activity molecular_function Methanothermobacter Methanothermobacter thermautotrophicus 0.0428724 0 0.0795225 0 0 0.0570135 GO:0090614 5'-methylthioadenosine deaminase activity molecular_function Clostridium Clostridium thermocellum 2.16138 9.32091 3.97432 40.4601 33.0883 28.9094 GO:0097054 L-glutamate biosynthetic process biological_process Escherichia Escherichia coli 0.0766064 0 0 0 0 0 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process biological_process Clostridium Clostridium thermocellum 2.40476 16.8858 13.3064 39.3101 43.4919 37.9766 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 21.253 22.6975 16.1781 22.7479 24.3709 26.15 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process biological_process Escherichia Escherichia coli 0.118871 0 0 0 0 0 GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.139675 0.167605 0.22675 0.303739 0.15587 0.232323 GO:0097098 DNA/RNA hybrid annealing activity molecular_function Escherichia Escherichia coli 0.0579166 0 0.0179072 0 0 0.0256771 GO:0097171 ADP-L-glycero-beta-D-manno-heptose biosynthetic process biological_process Escherichia Escherichia coli 0.257234 0 0.282501 0 0 0 GO:0097173 N-acetylmuramic acid catabolic process biological_process Escherichia Escherichia coli 0.133721 0 0 0 0 0 GO:0097175 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process biological_process Escherichia Escherichia coli 0.065062 0 0 0 0 0 GO:0097264 self proteolysis biological_process Clostridium Clostridium thermocellum 3.58145 16.78 9.44676 44.9418 44.3139 57.1423 GO:0097264 self proteolysis biological_process Escherichia Escherichia coli 0.292548 0 0.320255 0 0 0.0456625 GO:0097588 archaeal or bacterial-type flagellum-dependent cell motility biological_process Clostridium Clostridium thermocellum 13.7278 62.6596 40.8665 354.209 319.508 260.352 GO:0098655 cation transmembrane transport biological_process Escherichia Escherichia coli 0.610712 0 0 0 0 0.0281348 GO:1900190 regulation of single-species biofilm formation biological_process Escherichia Escherichia coli 0.0483165 0 0 0 0 0 GO:1900191 negative regulation of single-species biofilm formation biological_process Escherichia Escherichia coli 1.52821 0 0 0 0 0 GO:1900751 4-(trimethylammonio)butanoate transport biological_process Escherichia Escherichia coli 0.0349249 0 0 0 0 0 GO:1900753 doxorubicin transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0 0.391685 0.32851 0.1772 0 0.225143 GO:1901137 carbohydrate derivative biosynthetic process biological_process Clostridium Clostridium thermocellum 2.87425 5.07356 2.99064 34.4445 23.9786 17.6544 GO:1901137 carbohydrate derivative biosynthetic process biological_process Coprothermobacter Coprothermobacter proteolyticus 16.418 12.2322 8.50232 16.6672 18.6474 15.7124 GO:1901137 carbohydrate derivative biosynthetic process biological_process Escherichia Escherichia coli 0.0289704 0 0 0 0 0 GO:1901137 carbohydrate derivative biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.119795 0.431311 0.305731 0.612874 0.320878 0.91629 GO:1901264 carbohydrate derivative transport biological_process Escherichia Escherichia coli 0.0959524 0 0 0 0 0.0780984 GO:1901285 5,6,7,8-tetrahydromethanopterin biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.170687 0.166391 0.479796 0.177249 0.232048 0.115288 GO:1901530 response to hypochlorite biological_process Escherichia Escherichia coli 0.174382 0 0 0 0 0 GO:1901652 response to peptide biological_process Escherichia Escherichia coli 0.0514031 0 0 0 0 0 GO:1901682 sulfur compound transmembrane transporter activity molecular_function Escherichia Escherichia coli 0.300422 0 0 0 0 0 GO:1902021 regulation of bacterial-type flagellum-dependent cell motility biological_process Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:1902201 negative regulation of bacterial-type flagellum-dependent cell motility biological_process Escherichia Escherichia coli 0.519645 0 0 0 0 0.122855 GO:1902209 negative regulation of bacterial-type flagellum assembly biological_process Escherichia Escherichia coli 0.0632148 0 0 0 0 0 GO:1902475 L-alpha-amino acid transmembrane transport biological_process Escherichia Escherichia coli 0.707175 0 0.523098 0 0 0.179351 GO:1902599 sulfathiazole transmembrane transport biological_process Escherichia Escherichia coli 0.0266372 0 0.0494366 0 0 0 GO:1902760 Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process biological_process Escherichia Escherichia coli 0.169958 0 0.210286 0 0 0 GO:1902765 L-arginine import into cell biological_process Escherichia Escherichia coli 0.0835087 0 0.154985 0 0 0 GO:1902777 6-sulfoquinovose(1-) catabolic process biological_process Escherichia Escherichia coli 0.162084 0 0.0826348 0 0 0 GO:1903401 L-lysine transmembrane transport biological_process Escherichia Escherichia coli 0.129711 0 0 0 0 0 GO:1903506 regulation of nucleic acid-templated transcription biological_process Escherichia Escherichia coli 0.0604685 0 0 0 0 0 GO:1903658 positive regulation of type IV pilus biogenesis biological_process Escherichia Escherichia coli 0.201602 0 0.187552 0 0 0 GO:1903716 guanine transmembrane transport biological_process Escherichia Escherichia coli 0.0803249 0 0 0 0 0.0530681 GO:1903785 L-valine transmembrane transport biological_process Escherichia Escherichia coli 0.26941 0 0 0 0 0 GO:1903791 uracil transmembrane transport biological_process Escherichia Escherichia coli 0 0 0 0 0 0.0548468 GO:1903825 organic acid transmembrane transport biological_process Escherichia Escherichia coli 0.0374282 0 0.0694638 0 0 0 GO:1903874 ferrous iron transmembrane transport biological_process Escherichia Escherichia coli 0.135349 0 0 0 0 0 GO:1990663 dihydroorotate dehydrogenase (fumarate) activity molecular_function Coprothermobacter Coprothermobacter proteolyticus 0.864033 0.484005 0.13365 0.257804 0.353627 0.431174 GO:2000142 regulation of DNA-templated transcription, initiation biological_process Escherichia Escherichia coli 0 0 0.0968433 0 0 0 GO:2000143 negative regulation of DNA-templated transcription, initiation biological_process Escherichia Escherichia coli 1.42047 0 0.406363 0 0 0 GO:2000144 positive regulation of DNA-templated transcription, initiation biological_process Escherichia Escherichia coli 0.090727 0 0 0 0 0 GO:2000145 regulation of cell motility biological_process Escherichia Escherichia coli 0.16534 0 0 0 0 0 GO:2000147 positive regulation of cell motility biological_process Escherichia Escherichia coli 1.05166 0 0 0 0 0 GO:2000186 negative regulation of phosphate transmembrane transport biological_process Escherichia Escherichia coli 0 0 0 0 0 0.112378 GO:2000186 negative regulation of phosphate transmembrane transport biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.0476602 0.184127 1.33312 0.689474 0.256333 0.636106 GO:2000678 negative regulation of transcription regulatory region DNA binding biological_process Escherichia Escherichia coli 0.0430911 0 0 0 0 0 GO:2000884 glucomannan catabolic process biological_process Clostridium Clostridium thermocellum 7.87794 11.7939 11.5945 20.9763 16.3192 17.9495 GO:2001059 D-tagatose 6-phosphate catabolic process biological_process Clostridium Clostridium thermocellum 9.86686 28.7165 21.6438 133.033 107.045 143.081 GO:2001059 D-tagatose 6-phosphate catabolic process biological_process Coprothermobacter Coprothermobacter proteolyticus 125.074 105.814 111.725 74.0842 99.1241 73.0471 GO:2001059 D-tagatose 6-phosphate catabolic process biological_process Escherichia Escherichia coli 0.191467 0 0.0810561 0 0 0 GO:2001070 starch binding molecular_function Clostridium Clostridium thermocellum 11.5 46.4104 40.8239 383.819 405.859 540.485 GO:2001118 tetrahydromethanopterin biosynthetic process biological_process Methanothermobacter Methanothermobacter thermautotrophicus 0.265619 0.71938 1.42789 0.202194 0.11852 0.439097 GO:2001295 malonyl-CoA biosynthetic process biological_process Escherichia Escherichia coli 0.0405149 0 0.150294 0 0 0.0539089