Mercurial > repos > eschen42 > mqppep_anova
changeset 28:896eb8ae1c8c draft
planemo upload for repository https://github.com/galaxyproteomics/tools-galaxyp/tree/master/tools/mqppep commit be6750cb1d7ae18e71b60ae6f2c55e5331105c4f
| author | eschen42 |
|---|---|
| date | Thu, 27 Oct 2022 19:48:51 +0000 |
| parents | 2e35f925c469 |
| children | 42b207aaa527 |
| files | elm_networkin_psp_uniprot_lut.tabular kinase_metadata.sql kseaapp_demo.R phosphoelm_kinase_upid_desc.lut run_planemo_test.sh run_r_linter.R shed.yml |
| diffstat | 7 files changed, 0 insertions(+), 1482 deletions(-) [+] |
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--- a/elm_networkin_psp_uniprot_lut.tabular Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,446 +0,0 @@ -UniProtID Accessions kinase networkin_id psp_id netphorest_group ECs gene_names Descriptions -A9UF07_HUMAN A9UF07 BCR-ABL1 (PSP) BCR-ABL1 BCR/ABL fusion 2.7.10.2;Non-specific protein-tyrosine kinase -AAK1_HUMAN Q2M2I8 AAK1 AAK1 AAK1 2.7.11.1 AAK1;KIAA1048 2.7.11.1;AP2-associated protein kinase 1;Adaptor-associated kinase 1 -AAKB1_HUMAN Q9Y478 AMPKB1 (PSP) AMPKB1 PRKAB1;AMPK 5'-AMP-activated protein kinase subunit beta-1;AMPK subunit beta-1;AMPKb -AAKG2_HUMAN Q9UGJ0 AMPKG2 (PSP) AMPKG2 PRKAG2 5'-AMP-activated protein kinase subunit gamma-2;AMPK gamma2;AMPK subunit gamma-2;H91620p;Isoform C of 5'-AMP-activated protein kinase subunit gamma-2 -AAPK1_HUMAN Q13131 AMPK_group AMPKa1 AMPKA1 AMPK_group 2.7.11.1;2.7.11.26;2.7.11.27;2.7.11.31 PRKAA1;AMPK1 2.7.11.1;2.7.11.26;5'-AMP-activated protein kinase catalytic subunit alpha-1;AMPK subunit alpha-1;Acetyl-CoA carboxylase kinase;ACACA kinase;2.7.11.27;Hydroxymethylglutaryl-CoA reductase kinase;HMGCR kinase;2.7.11.31;Tau-protein kinase PRKAA1;Isoform 2 of 5'-AMP-activated protein kinase catalytic subunit alpha-1 -AAPK2_HUMAN P54646 AMPK_group AMPKa2 AMPKA2 AMPK_group 2.7.11.1;2.7.11.27;2.7.11.31 AMPK;PRKAA2;AMPK2 2.7.11.1;Acetyl-CoA carboxylase kinase;ACACA kinase;2.7.11.27;Hydroxymethylglutaryl-CoA reductase kinase;HMGCR kinase;2.7.11.31;5'-AMP-activated protein kinase catalytic subunit alpha-2;AMPK subunit alpha-2 -ABL1_HUMAN P00519 Abl Abl Abl Abl_group 2.7.10.2 ABL1;ABL;JTK7 2.7.10.2;Tyrosine-protein kinase ABL1;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150 -ABL2_HUMAN P42684 Abl2 Abl2 Arg Abl_group 2.7.10.2 ARG;ABL2;ABLL EC 2.7.10.2;Tyrosine-protein kinase ABL2;Abelson murine leukemia viral oncogene homolog 2;Abelson tyrosine-protein kinase 2;Abelson-related gene protein;Tyrosine-protein kinase ARG -ACK1_HUMAN Q07912 TNK2 TNK2 Ack 2.7.10.2;2.7.11.1 TNK2;ACK1 2.7.11.1;2.7.10.2;Activated CDC42 kinase 1;ACK-1;Tyrosine kinase non-receptor protein 2 -ACV1B_HUMAN P36896 ALK4 (PSP) ALK4 2.7.11.30 ACVR1B;ACVRLK4;ALK4 EC 2.7.11.30;Activin receptor type-1B;Activin receptor type IB;ACTR-IB;Activin receptor-like kinase 4;ALK-4;Serine/threonine-protein kinase receptor R2;SKR2;Isoform 5 of Activin receptor type-1B -ACVL1_HUMAN P37023 ALK1 (PSP) ALK1 2.7.11.30 ACVRL1;ACVRLK1;ALK1 EC 2.7.11.30;TGF-B superfamily receptor type I;TSR-I;Serine/threonine-protein kinase receptor R3;SKR3;Activin receptor-like kinase 1;ALK-1 -ADCK5_HUMAN Q3MIX3 ADCK5 (PSP) ADCK5 ADCK5 Uncharacterized aarF domain-containing protein kinase 5;2.7.11.- -AKT1_HUMAN P31749 PKBalpha (NetworKIN) PKBalpha Akt1 PKB_group 2.7.11.1 AKT1;PKB;RAC 2.7.11.1;PKB;RAC-alpha serine/threonine-protein kinase;Protein kinase B;Protein kinase B alpha;PKB alpha;Proto-oncogene c-Akt;RAC-PK-alpha;Isoform 2 of RAC-alpha serine/threonine-protein kinase -AKT2_HUMAN P31751 PKB_beta PKBbeta Akt2 PKB_group 2.7.11.1 AKT2 EC 2.7.11.1;RAC-beta serine/threonine-protein kinase;Protein kinase Akt-2;Protein kinase B beta;PKB beta;RAC-PK-beta;Isoform 2 of RAC-beta serine/threonine-protein kinase -AKT3_HUMAN Q9Y243 PKB_group PKBgamma Akt3 PKB_group 2.7.11.1 AKT3;PKBG EC 2.7.11.1;RAC-gamma serine/threonine-protein kinase;Protein kinase Akt-3;Protein kinase B gamma;PKB gamma;RAC-PK-gamma;STK-2;Isoform 2 of RAC-gamma serine/threonine-protein kinase -ALK_HUMAN Q9UM73 ALK ALK ALK 2.7.10.1 ALK 2.7.10.1;ALK tyrosine kinase receptor;Anaplastic lymphoma kinase;CD246 -ALPK1_HUMAN Q96QP1 AlphaK3 (PSP) AlphaK3 2.7.11.1 ALPK1;KIAA1527;LAK 2.7.11.1;Alpha-protein kinase 1;Chromosome 4 kinase;Lymphocyte alpha-protein kinase;Isoform 2 of Alpha-protein kinase 1 -ALPK3_HUMAN Q96L96 MAK (NetworKIN) MAK RCK_group 2.7.11.1 ALPK3;KIAA1330;MAK 2.7.11.1;Alpha-protein kinase 3;Muscle alpha-protein kinase -ARAF_HUMAN P10398 ARAF (NetworKIN) ARAF ARAF ARAF_BRAF_RAF1_group 2.7.11.1 ARAF;ARAF1;PKS;PKS2 EC 2.7.11.1;Serine/threonine-protein kinase A-Raf;Proto-oncogene A-Raf;Proto-oncogene A-Raf-1;Proto-oncogene Pks;Isoform 2 of Serine/threonine-protein kinase A-Raf -ARBK1_HUMAN P25098 GRK-2 GRK2 GRK2 GRK_group 2.7.11.15 GRK2;ADRBK1;BARK;BARK1 Beta-adrenergic receptor kinase 1;Beta-ARK-1;2.7.11.15;G-protein coupled receptor kinase 2 -ARBK2_HUMAN P35626 GRK-3 GRK3 GRK3 GRK_group 2.7.11.15 GRK3;ADRBK2;BARK2 2.7.11.15;Beta-adrenergic receptor kinase 2;Beta-ARK-2;G-protein-coupled receptor kinase 3 -ARP2 P61160-2 ACTR2 (NetworKIN) ACTR2 ACTR2_ACTR2B_TGFbR2_group ARP2;ACTR2 Actin-like protein 2;Isoform 2 of Actin-related protein 2 -ARP2_HUMAN P61160 ACTR2 (NetworKIN) ACTR2 ACTR2_ACTR2B_TGFbR2_group ARP2;ACTR2 Actin-related protein 2;Actin-like protein 2 -ATM_HUMAN Q13315 ATM ATM ATM ATM_ATR_group 2.7.11.1 ATM 2.7.11.1;Serine-protein kinase ATM;Ataxia telangiectasia mutated;A-T mutated -ATR_HUMAN Q13535 ATR ATR ATR ATM_ATR_group 2.7.11.1 ATR;FRP1 EC 2.7.11.1;Serine/threonine-protein kinase ATR;Ataxia telangiectasia and Rad3-related protein;FRAP-related protein 1;Isoform 2 of Serine/threonine-protein kinase ATR -AURKA_HUMAN O14965 Aurora A AuroraA AurA AuroraA 2.7.11.1 AURKA;AIK;AIRK1;ARK1;AURA;AYK1;BTAK;IAK1;STK15;STK6 2.7.11.1;Aurora kinase A;Aurora 2;Aurora/IPL1-related kinase 1;ARK-1;Aurora-related kinase 1;hARK1;Breast tumor-amplified kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A -AURKB_HUMAN Q96GD4 Aurora B AuroraB AurB AuroraC_AuroraB_group 2.7.11.1 STK1;AURKB;AIK2;AIM1;AIRK2;ARK2;STK12;STK5 2.7.11.1;STK-1;Aurora kinase B;Aurora 1;Aurora- and IPL1-like midbody-associated protein 1;AIM-1;Aurora/IPL1-related kinase 2;ARK-2;Aurora-related kinase 2;Serine/threonine-protein kinase 12;Serine/threonine-protein kinase 5;Serine/threonine-protein kinase aurora-B;Isoform 3 of Aurora kinase B -AURKC_HUMAN Q9UQB9 AuroraC (NetworKIN) AuroraC AurC AuroraC_AuroraB_group 2.7.11.1 AURKC;AIE2;AIK3;AIRK3;ARK3;STK13 EC 2.7.11.1;Aurora kinase C;Aurora 3;Aurora/IPL1-related kinase 3;ARK-3;Aurora-related kinase 3;Aurora/IPL1/Eg2 protein 2;Serine/threonine-protein kinase 13;Serine/threonine-protein kinase aurora-C -BAZ1B_HUMAN Q9UIG0 WSTF (PSP) WSTF 2.7.10.2 BAZ1B;WBSC10;WBSCR10;WBSCR9;WSTF 2.7.10.2;Tyrosine-protein kinase BAZ1B;Bromodomain adjacent to zinc finger domain protein 1B;Williams syndrome transcription factor;Williams-Beuren syndrome chromosomal region 10 protein;Williams-Beuren syndrome chromosomal region 9 protein;hWALp2;Isoform 2 of Tyrosine-protein kinase BAZ1B -BCKD_HUMAN O14874 BCKDK BCKDK PDHK_group 2.7.11.4 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial;EC 2.7.11.4;Branched-chain alpha-ketoacid dehydrogenase kinase;BCKD-kinase;BCKDHKIN -BCR_HUMAN P11274 Bcr (PSP) Bcr 2.7.11.1 BCR;BCR1;D22S11 2.7.11.1;Breakpoint cluster region protein;Renal carcinoma antigen NY-REN-26 -BIEA_HUMAN P53004 BVR (PSP) BVR 1.3.1.24 BLVRA;BLVR;BVR 1.3.1.24;Biliverdin reductase A;BVR A;Biliverdin-IX alpha-reductase -BIP_HUMAN P11021 GRP78 (PSP) GRP78 3.6.4.10 HSPA5;GRP78 3.6.4.10;Endoplasmic reticulum chaperone BiP;78 kDa glucose-regulated protein;GRP-78;Binding-immunoglobulin protein;BiP;Heat shock protein 70 family protein 5;HSP70 family protein 5;Heat shock protein family A member 5;Immunoglobulin heavy chain-binding protein -BLK_HUMAN P51451 BLK BLK BLK Src_group 2.7.10.2 BLK 2.7.10.2;Tyrosine-protein kinase Blk;B lymphocyte kinase;p55-Blk -BMP2K_HUMAN Q9NSY1 BIKE (PSP) BIKE 2.7.11.1 BMP2K;BIKE;HRIHFB2017 2.7.11.1;BMP-2-inducible protein kinase;BIKe -BMR1B_HUMAN O00238 BMPR1B BMPR1B BMPR1B 2.7.11.30 BMPR1B 2.7.11.30;Bone morphogenetic protein receptor type-1B;BMP type-1B receptor;BMPR-1B;CDw293 -BMX_HUMAN P51813 BMX BMX Etk Tec_group 2.7.10.2 BMX EC 2.7.10.2;ETK;Cytoplasmic tyrosine-protein kinase BMX;Bone marrow tyrosine kinase gene in chromosome X protein;Epithelial and endothelial tyrosine kinase;NTK38 -BRAF_HUMAN P15056 BRAF (PSP) BRAF 2.7.11.1 BRAF;BRAF1;RAFB1 2.7.11.1;p94;Serine/threonine-protein kinase B-raf;Proto-oncogene B-Raf;v-Raf murine sarcoma viral oncogene homolog B1 -BRD4_HUMAN O60885 BRD4 (PSP) BRD4 BRD4;HUNK1 Bromodomain-containing protein 4;Protein HUNK1;Isoform B of Bromodomain-containing protein 4 -BRSK1 Q8TDC3-2 BRSK1 iso2 (PSP) BRSK1 iso2 BRSK1;KIAA1811;SAD1;SADB EC 2.7.11.1;EC 2.7.11.26;Brain-selective kinase 1;Brain-specific serine/threonine-protein kinase 1;BR serine/threonine-protein kinase 1;Serine/threonine-protein kinase SAD-B;Synapses of Amphids Defective homolog 1;SAD1 homolog;hSAD1;Isoform 2 of Serine/threonine-protein kinase BRSK1 -BRSK1_HUMAN Q8TDC3 BRSK1 BRSK1 BRSK1 2.7.11.1;2.7.11.26 BRSK1;KIAA1811;SAD1;SADB EC 2.7.11.1;EC 2.7.11.26;Serine/threonine-protein kinase BRSK1;Brain-selective kinase 1;Brain-specific serine/threonine-protein kinase 1;BR serine/threonine-protein kinase 1;Serine/threonine-protein kinase SAD-B;Synapses of Amphids Defective homolog 1;SAD1 homolog;hSAD1;Isoform 3 of Serine/threonine-protein kinase BRSK1 -BRSK2_HUMAN Q8IWQ3 BRSK2 (PSP) BRSK2 2.7.11.1;2.7.11.26 BRSK2;C11orf7;HUSSY-12 EC 2.7.11.1;EC 2.7.11.26;Serine/threonine-protein kinase BRSK2;Brain-selective kinase 2;Brain-specific serine/threonine-protein kinase 2;BR serine/threonine-protein kinase 2;Serine/threonine-protein kinase 29;Serine/threonine-protein kinase SAD-A;Isoform 6 of Serine/threonine-protein kinase BRSK2 -BTK_HUMAN Q06187 BTK BTK Btk Tec_group 2.7.10.2 BTK;AGMX1;ATK;BPK EC 2.7.10.2;ATK;BPK;Tyrosine-protein kinase BTK;Agammaglobulinemia tyrosine kinase;B-cell progenitor kinase;Bruton tyrosine kinase;Isoform BTK-C of Tyrosine-protein kinase BTK -BUB1_HUMAN O43683 BUB1 (PSP) BUB1 2.7.11.1 BUB1;BUB1L EC 2.7.11.1;Mitotic checkpoint serine/threonine-protein kinase BUB1;hBUB1;BUB1A -CD11A Q9UQ88-10 CDK11A iso10 (PSP) CDK11A iso10 CDK11A;CDC2L2;CDC2L3;PITSLREB EC 2.7.11.22;Galactosyltransferase-associated protein kinase p58/GTA;Cell division cycle 2-like protein kinase 2;Cell division protein kinase 11A;PITSLRE serine/threonine-protein kinase CDC2L2;Isoform SV1 of Cyclin-dependent kinase 11A;Isoform SV2 of Cyclin-dependent kinase 11A;Isoform SV3 of Cyclin-dependent kinase 11A;Isoform SV7 of Cyclin-dependent kinase 11A;Isoform SV12 of Cyclin-dependent kinase 11A;Isoform 4 of Cyclin-dependent kinase 11A -CD11A_HUMAN Q9UQ88 CDK11A (PSP) CDK11A 2.7.11.22 CDK11A;CDC2L2;CDC2L3;PITSLREB EC 2.7.11.22;Galactosyltransferase-associated protein kinase p58/GTA;Cyclin-dependent kinase 11A;Cell division cycle 2-like protein kinase 2;Cell division protein kinase 11A;PITSLRE serine/threonine-protein kinase CDC2L2;Isoform SV13 of Cyclin-dependent kinase 11A -CD11B_HUMAN P21127 CLK1 CLK1 CDK11B CLK_group 2.7.11.22 CDK11;CDK11B;CDC2L1;PITSLREA;PK58 EC 2.7.11.22;Cyclin-dependent kinase 11B;Cell division cycle 2-like protein kinase 1;CLK-1;Cell division protein kinase 11B;Galactosyltransferase-associated protein kinase p58/GTA;PITSLRE serine/threonine-protein kinase CDC2L1;p58 CLK-1;Isoform 8 of Cyclin-dependent kinase 11B -CDC7_HUMAN O00311 CDC7 (PSP) CDC7 2.7.11.1 CDC7;CDC7L1 EC 2.7.11.1;Cell division cycle 7-related protein kinase;CDC7-related kinase;HsCdc7;huCdc7 -CDK10_HUMAN Q15131 CDK10 (PSP) CDK10 2.7.11.22 CDK10 EC 2.7.11.22;Cyclin-dependent kinase 10;Cell division protein kinase 10;Serine/threonine-protein kinase PISSLRE;Isoform 7 of Cyclin-dependent kinase 10 -CDK12_HUMAN Q9NYV4 CDK12 (PSP) CDK12 2.7.11.22;2.7.11.23 CDK12;CRK7;CRKRS;KIAA0904 EC 2.7.11.22;2.7.11.23;Cyclin-dependent kinase 12;Cdc2-related kinase, arginine/serine-rich;CrkRS;Cell division cycle 2-related protein kinase 7;CDC2-related protein kinase 7;Cell division protein kinase 12;hCDK12 -CDK13_HUMAN Q14004 CDK13 (PSP) CDK13 2.7.11.22;2.7.11.23 CDK13;CDC2L;CDC2L5;CHED;KIAA1791 EC 2.7.11.22;Cyclin-dependent kinase 13;EC 2.7.11.23;CDC2-related protein kinase 5;Cell division cycle 2-like protein kinase 5;Cell division protein kinase 13;hCDK13;Cholinesterase-related cell division controller -CDK14_HUMAN O94921 CDK14 (PSP) CDK14 2.7.11.22 CDK14;KIAA0834;PFTK1 EC 2.7.11.22;Cyclin-dependent kinase 14;Cell division protein kinase 14;Serine/threonine-protein kinase PFTAIRE-1;hPFTAIRE1;Isoform 2 of Cyclin-dependent kinase 14 -CDK16_HUMAN Q00536 PCTAIRE1 PCTAIRE1 CDK16 2.7.11.22 CDK16;PCTAIRE1;PCTK1 EC 2.7.11.22;Cyclin-dependent kinase 16;Cell division protein kinase 16;PCTAIRE-motif protein kinase 1;Serine/threonine-protein kinase PCTAIRE-1 -CDK18_HUMAN Q07002 CDK18 (PSP) CDK18 2.7.11.22 CDK18;PCTAIRE3;PCTK3 EC 2.7.11.22;Cyclin-dependent kinase 18;Cell division protein kinase 18;PCTAIRE-motif protein kinase 3;Serine/threonine-protein kinase PCTAIRE-3;Isoform 2 of Cyclin-dependent kinase 18 -CDK19_HUMAN Q9BWU1 CDK11 CDK11 CDK19 2.7.11.22 CDK19;CDC2L6;CDK11;KIAA1028 EC 2.7.11.22;Cyclin-dependent kinase 19;CDC2-related protein kinase 6;Cell division cycle 2-like protein kinase 6;Cell division protein kinase 19;Cyclin-dependent kinase 11;Death-preventing kinase -CDK1_HUMAN P06493 CDK1 CDK1 CDK1 CDK2_CDK3_CDK1_CDK5_group 2.7.11.22;2.7.11.23 CDK1;CDC2;CDC28A;CDKN1;P34CDC2 CDK1;Cyclin-dependent kinase 1;2.7.11.22;2.7.11.23;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;Isoform 2 of Cyclin-dependent kinase 1 -CDK20_HUMAN Q8IZL9 CDK20 (PSP) CDK20 2.7.11.22 CDK20;CCRK;CDCH EC 2.7.11.22;Cyclin-dependent kinase 20;CDK-activating kinase p42;CAK-kinase p42;Cell cycle-related kinase;Cell division protein kinase 20;Cyclin-dependent protein kinase H;Cyclin-kinase-activating kinase p42;Isoform 2 of Cyclin-dependent kinase 20 -CDK2_HUMAN P24941 CDK2 CDK2 CDK2 CDK2_CDK3_CDK1_CDK5_group 2.7.11.22 CDK2;CDKN2 2.7.11.22;Cyclin-dependent kinase 2;Cell division protein kinase 2;p33 protein kinase -CDK3_HUMAN Q00526 CDK3 CDK3 CDK3 CDK2_CDK3_CDK1_CDK5_group 2.7.11.22 CDK3;CDKN3 EC 2.7.11.22;Cyclin-dependent kinase 3;Cell division protein kinase 3 -CDK4_HUMAN P11802 CDK4 CDK4 CDK4 CDK4_CDK6_group 2.7.11.22 CDK4 EC 2.7.11.22;Cyclin-dependent kinase 4;Cell division protein kinase 4;PSK-J3;Isoform 2 of Cyclin-dependent kinase 4 -CDK5_HUMAN Q00535 CDK5 CDK5 CDK5 CDK2_CDK3_CDK1_CDK5_group 2.7.11.1 CDK5;CDKN5;PSSALRE EC 2.7.11.1;Cyclin-dependent kinase 5;Cell division protein kinase 5;Cyclin-dependent-like kinase 5;Serine/threonine-protein kinase PSSALRE;Tau protein kinase II catalytic subunit;TPKII catalytic subunit -CDK6_HUMAN Q00534 CDK6 CDK6 CDK6 CDK4_CDK6_group 2.7.11.22 CDK6;CDKN6 EC 2.7.11.22;Cyclin-dependent kinase 6;Cell division protein kinase 6;Serine/threonine-protein kinase PLSTIRE -CDK7_HUMAN P50613 CDK7 CDK7 CDK7 CDK7 2.7.11.22;2.7.11.23 CAK;STK1;CDK7;CAK1;CDKN7;MO15 EC 2.7.11.22;2.7.11.23;Cyclin-dependent kinase 7;39 kDa protein kinase;p39 Mo15;CDK-activating kinase 1;Cell division protein kinase 7;Serine/threonine-protein kinase 1;TFIIH basal transcription factor complex kinase subunit -CDK8_HUMAN P49336 CDK8 (PSP) CDK8 2.7.11.22;2.7.11.23 CDK8 EC 2.7.11.22;EC 2.7.11.23;Cyclin-dependent kinase 8;Cell division protein kinase 8;Mediator complex subunit CDK8;Mediator of RNA polymerase II transcription subunit CDK8;Protein kinase K35;Isoform 2 of Cyclin-dependent kinase 8 -CDK9_HUMAN P50750 CDK9 CDK9 CDK9 2.7.11.22;2.7.11.23 CDK9;CDC2L4;TAK 2.7.11.22;2.7.11.23;Cyclin-dependent kinase 9;C-2K;Cell division cycle 2-like protein kinase 4;Cell division protein kinase 9;Serine/threonine-protein kinase PITALRE;Tat-associated kinase complex catalytic subunit;Isoform 2 of Cyclin-dependent kinase 9 -CDKL2_HUMAN Q92772 CDKL2 (PSP) CDKL2 2.7.11.22 CDKL2 EC 2.7.11.22;Cyclin-dependent kinase-like 2;Protein kinase p56 KKIAMRE;Serine/threonine-protein kinase KKIAMRE -CDKL5_HUMAN O76039 CDKL5 (PSP) CDKL5 2.7.11.22 CDKL5;STK9 EC 2.7.11.22;Cyclin-dependent kinase-like 5;Serine/threonine-protein kinase 9;Isoform 2 of Cyclin-dependent kinase-like 5 -CERT_HUMAN Q9Y5P4 COL4A3BP (PSP) COL4A3BP CERT1;CERT;COL4A3BP;STARD11 GPBP;Ceramide transfer protein;hCERT;Collagen type IV alpha-3-binding protein;Goodpasture antigen-binding protein;START domain-containing protein 11;StARD11;StAR-related lipid transfer protein 11;Isoform 3 of Ceramide transfer protein -CHK1_HUMAN O14757 CHK1 CHK1 Chk1 2.7.11.1 CHEK1;CHK1 2.7.11.1;Serine/threonine-protein kinase Chk1;CHK1 checkpoint homolog;Cell cycle checkpoint kinase;Checkpoint kinase-1;Isoform 3 of Serine/threonine-protein kinase Chk1 -CHK2_HUMAN O96017 CHK2 CHK2 Chk2 2.7.11.1 CHEK2;CDS1;CHK2;RAD53 EC 2.7.11.1;Serine/threonine-protein kinase Chk2;CHK2 checkpoint homolog;Cds1 homolog;Hucds1;hCds1;Checkpoint kinase 2;Isoform 9 of Serine/threonine-protein kinase Chk2 -CILK1_HUMAN Q9UPZ9 ICK ICK ICK RCK_group 2.7.11.1 CILK1;ICK;KIAA0936 2.7.11.1;MRK;Serine/threonine-protein kinase ICK;Ciliogenesis associated kinase 1;Intestinal cell kinase;hICK;Laryngeal cancer kinase 2;LCK2;MAK-related kinase -CLK1_HUMAN P49759 CLK1 CLK1 CLK1 CLK_group 2.7.12.1 CLK1;CLK EC 2.7.12.1;Dual specificity protein kinase CLK1;CDC-like kinase 1;Isoform 2 of Dual specificity protein kinase CLK1 -CLK2_HUMAN P49760 CLK2 (NetworKIN) CLK2 CLK2 CLK_group 2.7.12.1 CLK2 Dual specificity protein kinase CLK2;EC 2.7.12.1;CDC-like kinase 2;Isoform 2 of Dual specificity protein kinase CLK2 -CLK3_HUMAN P49761 CLK3 (NetworKIN) CLK3 CLK3 CLK_group 2.7.12.1 CLK3 EC 2.7.12.1;Dual specificity protein kinase CLK3;CDC-like kinase 3;Isoform 1 of Dual specificity protein kinase CLK3 -CLK4_HUMAN Q9HAZ1 CLK4 (NetworKIN) CLK4 CLK4 CLK_group 2.7.12.1 CLK4 EC 2.7.12.1;Dual specificity protein kinase CLK4;CDC-like kinase 4 -CSF1R_HUMAN P07333 CSF1R CSF1R CSFR FLT3_CSF1R_Kit_PDGFR_group 2.7.10.1 CSF1R;FMS EC 2.7.10.1;Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor;CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD115;Isoform 2 of Macrophage colony-stimulating factor 1 receptor -CSK21_HUMAN P68400 CK2_alpha CK2alpha CK2A1 CK2_group 2.7.11.1 CSNK2A1;CK2A1 2.7.11.1;Casein kinase II subunit alpha;CK II alpha -CSK22_HUMAN P19784 CK2a2 (NetworKIN) CK2a2 CK2A2 CK2_group 2.7.11.1 CSNK2A2;CK2A2 EC 2.7.11.1;Casein kinase II subunit alpha';CK II alpha' -CSK2B_HUMAN P67870 CK2_beta CK2_beta CK2B CSNK2B;CK2N;G5A Casein kinase II subunit beta;CK II beta;Phosvitin;Protein G5a -CSKP_HUMAN O14936 CASK (PSP) CASK 2.7.11.1 CASK;LIN2 2.7.11.1;Peripheral plasma membrane protein CASK;hCASK;Calcium/calmodulin-dependent serine protein kinase;Protein lin-2 homolog -CSK_HUMAN P41240 Csk Csk CSK 2.7.10.2 CSK 2.7.10.2;Tyrosine-protein kinase CSK;C-Src kinase;Protein-tyrosine kinase CYL -CTRO_HUMAN O14578 CRIK (PSP) CRIK 2.7.11.1 CIT;CRIK;KIAA0949;STK21 2.7.11.1;CRIK;Citron Rho-interacting kinase;Serine/threonine-protein kinase 21;Isoform 2 of Citron Rho-interacting kinase -DAPK1_HUMAN P53355 DAPK1 DAPK1 DAPK1 DAPK_group 2.7.11.1 DAPK1;DAPK EC 2.7.11.1;Death-associated protein kinase 1;DAP kinase 1 -DAPK2_HUMAN Q9UIK4 DAPK2 DAPK2 DAPK2 DAPK_group 2.7.11.1 DAPK2 2.7.11.1;Death-associated protein kinase 2;DAP kinase 2;DAP-kinase-related protein 1;DRP-1;Isoform 2 of Death-associated protein kinase 2 -DAPK3_HUMAN O43293 DAPK3 DAPK3 DAPK3 DAPK_group 2.7.11.1 DAPK3;ZIPK 2.7.11.1;Death-associated protein kinase 3;DAP kinase 3;DAP-like kinase;Dlk;MYPT1 kinase;Zipper-interacting protein kinase;ZIP-kinase -DCLK1_HUMAN O15075 DCAMKL1 DCAMKL1 2.7.11.1 DCLK1;DCAMKL1;DCDC3A;KIAA0369 EC 2.7.11.1;Serine/threonine-protein kinase DCLK1;Doublecortin domain-containing protein 3A;Doublecortin-like and CAM kinase-like 1;Doublecortin-like kinase 1;Isoform 4 of Serine/threonine-protein kinase DCLK1 -DDR1_HUMAN Q08345 DDR1 (PSP) DDR1 2.7.10.1 NEP;DDR1;CAK;EDDR1;NTRK4;PTK3A;RTK6;TRKE EC 2.7.10.1;Epithelial discoidin domain-containing receptor 1;Epithelial discoidin domain receptor 1;CD167 antigen-like family member A;Cell adhesion kinase;Discoidin receptor tyrosine kinase;HGK2;Mammary carcinoma kinase 10;MCK-10;Protein-tyrosine kinase 3A;Protein-tyrosine kinase RTK-6;TRK E;Tyrosine kinase DDR;Tyrosine-protein kinase CAK;CD167a -DMPK_HUMAN Q09013 DMPK_group DMPK1 DMPK1 DMPK_group 2.7.11.1 DMPK;DM1PK;MDPK EC 2.7.11.1;DMPK;Myotonin-protein kinase;MT-PK;DM-kinase;DMK;DM1 protein kinase;Myotonic dystrophy protein kinase;Isoform 3 of Myotonin-protein kinase -DYR1A_HUMAN Q13627 DYRK1A DYRK1A DYRK1A 2.7.12.1 DYRK1A;DYRK;MNB;MNBH MNBH;Dual specificity tyrosine-phosphorylation-regulated kinase 1A;2.7.12.1;Dual specificity YAK1-related kinase;HP86;Protein kinase minibrain homolog;hMNB;Isoform 4 of Dual specificity tyrosine-phosphorylation-regulated kinase 1A -DYR1B_HUMAN Q9Y463 DYRK1B DYRK1B DYRK1B 2.7.12.1 DYRK1B;MIRK 2.7.12.1;Dual specificity tyrosine-phosphorylation-regulated kinase 1B;Minibrain-related kinase;Mirk protein kinase -DYRK2_HUMAN Q92630 DYRK2 DYRK2 DYRK2 2.7.12.1 DYRK2 2.7.12.1;Dual specificity tyrosine-phosphorylation-regulated kinase 2;Isoform 2 of Dual specificity tyrosine-phosphorylation-regulated kinase 2 -DYRK3_HUMAN O43781 DYRK3 DYRK3 DYRK3 2.7.12.1 DYRK3 2.7.12.1;Dual specificity tyrosine-phosphorylation-regulated kinase 3;Regulatory erythroid kinase;REDK -DYRK4_HUMAN Q9NR20 DYRK4 (PSP) DYRK4 2.7.12.1 DYRK4 EC 2.7.12.1;Dual specificity tyrosine-phosphorylation-regulated kinase 4 -E2AK1_HUMAN Q9BQI3 HRI HRI HRI 2.7.11.1 EIF2AK1;HRI;PRO1362 2.7.11.1;Eukaryotic translation initiation factor 2-alpha kinase 1;Heme-controlled repressor;HCR;Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase;Heme-regulated inhibitor;hHRI;Hemin-sensitive initiation factor 2-alpha kinase;Isoform 2 of Eukaryotic translation initiation factor 2-alpha kinase 1 -E2AK2_HUMAN P19525 EIF2AK2 EIF2AK2 PKR EIF2AK2 2.7.10.2;2.7.11.1 EIF2AK2;PKR;PRKR EC 2.7.11.1;EC 2.7.10.2;PKR;Interferon-induced, double-stranded RNA-activated protein kinase;Eukaryotic translation initiation factor 2-alpha kinase 2;eIF-2A protein kinase 2;Interferon-inducible RNA-dependent protein kinase;P1/eIF-2A protein kinase;Protein kinase RNA-activated;Protein kinase R;Tyrosine-protein kinase EIF2AK2;p68 kinase -E2AK3_HUMAN Q9NZJ5 EIF2AK3 EIF2AK3 PERK 2.7.11.1 EIF2AK3;PEK;PERK EC 2.7.11.1;Eukaryotic translation initiation factor 2-alpha kinase 3;PRKR-like endoplasmic reticulum kinase;Pancreatic eIF2-alpha kinase;HsPEK -E2AK4_HUMAN Q9P2K8 GCN2 (PSP) GCN2 2.7.11.1 EIF2AK4;GCN2;KIAA1338 2.7.11.1;eIF-2-alpha kinase GCN2;Eukaryotic translation initiation factor 2-alpha kinase 4;GCN2-like protein;Isoform 2 of eIF-2-alpha kinase GCN2 -EF2K_HUMAN O00418 EEF2K (PSP) EEF2K 2.7.11.20 EEF2K Eukaryotic elongation factor 2 kinase;eEF-2 kinase;eEF-2K;2.7.11.20;Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase -EGFR_HUMAN P00533 EGFR EGFR EGFR EGFR_group 2.7.10.1 EGFR;ERBB;ERBB1;HER1 EC 2.7.10.1;Epidermal growth factor receptor;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;Isoform 3 of Epidermal growth factor receptor -ENPP3_HUMAN O14638 ENPP3 (PSP) ENPP3 3.1.4.1;3.6.1.9 ENPP3;PDNP3 3.6.1.9;3.1.4.1;Alkaline phosphodiesterase I;Nucleotide pyrophosphatase;NPPase;Nucleotide diphosphatase;Ectonucleotide pyrophosphatase/phosphodiesterase family member 3;E-NPP 3;NPP3;Phosphodiesterase I beta;PD-Ibeta;Phosphodiesterase I/nucleotide pyrophosphatase 3;CD203c -EPHA1_HUMAN P21709 EphA1 (NetworKIN) EphA1 EphA1 Eph_group 2.7.10.1 EPHA1;EPH;EPHT;EPHT1 EC 2.7.10.1;Ephrin type-A receptor 1;hEpha1;EPH tyrosine kinase;EPH tyrosine kinase 1;Erythropoietin-producing hepatoma receptor;Tyrosine-protein kinase receptor EPH;Isoform 3 of Ephrin type-A receptor 1 -EPHA2_HUMAN P29317 EphA2 EphA2 EphA2 Eph_group 2.7.10.1 EPHA2;ECK EC 2.7.10.1;Ephrin type-A receptor 2;Epithelial cell kinase;Tyrosine-protein kinase receptor ECK -EPHA3_HUMAN P29320 EphA3 EphA3 Eph_group 2.7.10.1 EPHA3;ETK;ETK1;HEK;TYRO4 EC 2.7.10.1;HEK;Ephrin type-A receptor 3;EPH-like kinase 4;EK4;hEK4;Human embryo kinase;Tyrosine-protein kinase TYRO4;Tyrosine-protein kinase receptor ETK1;Eph-like tyrosine kinase 1 -EPHA4_HUMAN P54764 EphA4 EphA4 EphA4 Eph_group 2.7.10.1 EPHA4;HEK8;SEK;TYRO1 Ephrin type-A receptor 4;EC 2.7.10.1;EPH-like kinase 8;EK8;hEK8;Tyrosine-protein kinase TYRO1;Tyrosine-protein kinase receptor SEK;Isoform 2 of Ephrin type-A receptor 4 -EPHA5_HUMAN P54756 EphA5 (NetworKIN) EphA5 Eph_group 2.7.10.1 TYRO4;EPHA5;BSK;EHK1;HEK7 EC 2.7.10.1;Ephrin type-A receptor 5;Brain-specific kinase;EPH homology kinase 1;EHK-1;EPH-like kinase 7;EK7;hEK7;Isoform 3 of Ephrin type-A receptor 5 -EPHA6_HUMAN Q9UF33 EphA6 (NetworKIN) EphA6 Eph_group 2.7.10.1 EPHA6;EHK2;HEK12 EC 2.7.10.1;Ephrin type-A receptor 6;EPH homology kinase 2;EHK-2;EPH-like kinase 12;EK12;Isoform 3 of Ephrin type-A receptor 6 -EPHA7_HUMAN Q15375 EphA7 (NetworKIN) EphA7 Eph_group 2.7.10.1 EPHA7;EHK3;HEK11 EC 2.7.10.1;Ephrin type-A receptor 7;EPH homology kinase 3;EHK-3;EPH-like kinase 11;EK11;hEK11;Isoform 5 of Ephrin type-A receptor 7 -EPHA8_HUMAN P29322 EphA8 EphA8 Eph_group 2.7.10.1 EPHA8;EEK;HEK3;KIAA1459 EC 2.7.10.1;Ephrin type-A receptor 8;EPH- and ELK-related kinase;EPH-like kinase 3;EK3;hEK3;Tyrosine-protein kinase receptor EEK -EPHB1_HUMAN P54762 EphB1 EphB1 EphB1 Eph_group 2.7.10.1 NET;EPHB1;ELK;EPHT2;HEK6 EC 2.7.10.1;NET;ELK;Ephrin type-B receptor 1;EPH tyrosine kinase 2;EPH-like kinase 6;EK6;hEK6;Neuronally-expressed EPH-related tyrosine kinase;Tyrosine-protein kinase receptor EPH-2 -EPHB2_HUMAN P29323 EphB2 EphB2 EphB2 Eph_group 2.7.10.1 EPHB2;DRT;EPHT3;EPTH3;ERK;HEK5;TYRO5 EC 2.7.10.1;Ephrin type-B receptor 2;Developmentally-regulated Eph-related tyrosine kinase;ELK-related tyrosine kinase;EPH tyrosine kinase 3;EPH-like kinase 5;EK5;hEK5;Renal carcinoma antigen NY-REN-47;Tyrosine-protein kinase TYRO5;Tyrosine-protein kinase receptor EPH-3;EphB2/CTF1;EphB2/CTF2;Isoform 3 of Ephrin type-B receptor 2 -EPHB3_HUMAN P54753 EphB3 EphB3 EphB3 Eph_group 2.7.10.1 EPHB3;ETK2;HEK2;TYRO6 EC 2.7.10.1;Ephrin type-B receptor 3;EPH-like tyrosine kinase 2;EPH-like kinase 2;Embryonic kinase 2;EK2;hEK2;Tyrosine-protein kinase TYRO6 -EPHB4_HUMAN P54760 EphB4 (NetworKIN) EphB4 Eph_group 2.7.10.1 EPHB4;HTK;MYK1;TYRO11 EC 2.7.10.1;Ephrin type-B receptor 4;Hepatoma transmembrane kinase;Tyrosine-protein kinase TYRO11;Isoform 4 of Ephrin type-B receptor 4 -EPHB6 EphB6 (NetworKIN) EphB6 Eph_group EPHB6 HEP;Tyrosine-protein kinase-defective receptor EPH-6;Isoform 2 of Ephrin type-B receptor 6 -EPHB6_HUMAN EphB6 (NetworKIN) EphB6 Eph_group EPHB6 HEP;Ephrin type-B receptor 6;Tyrosine-protein kinase-defective receptor EPH-6;Isoform 3 of Ephrin type-B receptor 6 -ERBB2_HUMAN P04626 ErbB2 ErbB2 HER2 EGFR_group 2.7.10.1 ERBB2;HER2;MLN19;NEU;NGL EC 2.7.10.1;Receptor tyrosine-protein kinase erbB-2;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD340 -ERBB3_HUMAN P21860 ErbB3 (NetworKIN) ErbB3 EGFR_group 2.7.10.1 ERBB3;HER3 EC 2.7.10.1;Receptor tyrosine-protein kinase erbB-3;Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3;Isoform 4 of Receptor tyrosine-protein kinase erbB-3 -ERBB4_HUMAN Q15303 ErbB4 (NetworKIN) ErbB4 HER4 EGFR_group 2.7.10.1 ERBB4;HER4 EC 2.7.10.1;Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4;Tyrosine kinase-type cell surface receptor HER4;p180erbB4;ERBB4 intracellular domain;4ICD;E4ICD;s80HER4;Isoform JM-B CYT-2 of Receptor tyrosine-protein kinase erbB-4 -ERN1_HUMAN O75460 IRE1 (PSP) IRE1 2.7.11.1 ERN1;IRE1 2.7.11.1;Serine/threonine-protein kinase/endoribonuclease IRE1;Endoplasmic reticulum-to-nucleus signaling 1;Inositol-requiring protein 1;hIRE1p;Ire1-alpha;IRE1a;Serine/threonine-protein kinase;Endoribonuclease;3.1.26.- -FA20C_HUMAN Q8IXL6 FAM20C (PSP) FAM20C 2.7.11.1 FAM20C;DMP4 2.7.11.1;Extracellular serine/threonine protein kinase FAM20C;Dentin matrix protein 4;DMP-4;Golgi casein kinase;Golgi-enriched fraction casein kinase;GEF-CK -FAK1_HUMAN Q05397 FAK FAK FAK 2.7.10.2 PTK2;FAK;FAK1 EC 2.7.10.2;Focal adhesion kinase 1;FADK 1;Focal adhesion kinase-related nonkinase;FRNK;Protein phosphatase 1 regulatory subunit 71;PPP1R71;Protein-tyrosine kinase 2;p125FAK;pp125FAK -FAK2_HUMAN Q14289 PYK2 PYK2 Pyk2 2.7.10.2 PTK2B;FAK2;PYK2;RAFTK EC 2.7.10.2;RAFTK;Protein-tyrosine kinase 2-beta;Calcium-dependent tyrosine kinase;CADTK;Calcium-regulated non-receptor proline-rich tyrosine kinase;Cell adhesion kinase beta;CAK-beta;CAKB;Focal adhesion kinase 2;FADK 2;Proline-rich tyrosine kinase 2;Related adhesion focal tyrosine kinase -FER_HUMAN P16591 Fer Fer Fer 2.7.10.2 FER;TYK3 Tyrosine-protein kinase Fer;EC 2.7.10.2;Feline encephalitis virus-related kinase FER;Fujinami poultry sarcoma/Feline sarcoma-related protein Fer;Proto-oncogene c-Fer;Tyrosine kinase 3;p94-Fer;Isoform 2 of Tyrosine-protein kinase Fer -FES_HUMAN P07332 Fes Fes Fes 2.7.10.2 FPS;FES EC 2.7.10.2;Tyrosine-protein kinase Fes/Fps;Feline sarcoma/Fujinami avian sarcoma oncogene homolog;Proto-oncogene c-Fes;Proto-oncogene c-Fps;p93c-fes;Isoform 3 of Tyrosine-protein kinase Fes/Fps -FGFR1_HUMAN P11362 FGFR1 FGFR1 FGFR1 2.7.10.1 FGFR1;BFGFR;CEK;FGFBR;FLG;FLT2;HBGFR 2.7.10.1;BFGFR;Fibroblast growth factor receptor 1;FGFR-1;Basic fibroblast growth factor receptor 1;bFGF-R-1;Fms-like tyrosine kinase 2;FLT-2;N-sam;Proto-oncogene c-Fgr;CD331;Isoform 5 of Fibroblast growth factor receptor 1 -FGFR2_HUMAN P21802 FGFR2 (PSP) FGFR2 2.7.10.1 FGFR2;BEK;KGFR;KSAM 2.7.10.1;KGFR;Fibroblast growth factor receptor 2;FGFR-2;K-sam;Keratinocyte growth factor receptor;CD332;Isoform 9 of Fibroblast growth factor receptor 2 -FGFR3_HUMAN P22607 FGFR3 FGFR3 FGFR3 2.7.10.1 FGFR3;JTK4 EC 2.7.10.1;Fibroblast growth factor receptor 3;FGFR-3;CD333 -FGFR4_HUMAN P22455 FGFR4 FGFR4 FGFR4 2.7.10.1 FGFR4;JTK2;TKF EC 2.7.10.1;Fibroblast growth factor receptor 4;FGFR-4;CD334;Isoform 3 of Fibroblast growth factor receptor 4 -FGR_HUMAN P09769 Fgr Fgr FGR Src_group 2.7.10.2 SRC2;FGR EC 2.7.10.2;Proto-oncogene c-Fgr;Tyrosine-protein kinase Fgr;Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog;p55-Fgr;p58-Fgr;p58c-Fgr -FLT3_HUMAN P36888 FLT3 FLT3 FLT3 FLT3_CSF1R_Kit_PDGFR_group 2.7.10.1 FLT3;CD135;FLK2;STK1 EC 2.7.10.1;CD135;Receptor-type tyrosine-protein kinase FLT3;FL cytokine receptor;Fetal liver kinase-2;FLK-2;Fms-like tyrosine kinase 3;FLT-3;Stem cell tyrosine kinase 1;STK-1;Isoform 2 of Receptor-type tyrosine-protein kinase FLT3 -FRK_HUMAN P42685 FRK (NetworKIN) FRK FRK FRK 2.7.10.2 FRK;PTK5;RAK EC 2.7.10.2;Tyrosine-protein kinase FRK;FYN-related kinase;Nuclear tyrosine protein kinase RAK;Protein-tyrosine kinase 5 -FRK_HUMAN P42685 FRK (NetworKIN) FRK FRK Src_group 2.7.10.2 FRK;PTK5;RAK EC 2.7.10.2;Tyrosine-protein kinase FRK;FYN-related kinase;Nuclear tyrosine protein kinase RAK;Protein-tyrosine kinase 5 -FYN_HUMAN P06241 Fyn Fyn Fyn Src_group 2.7.10.2 FYN EC 2.7.10.2;SLK;Tyrosine-protein kinase Fyn;Proto-oncogene Syn;Proto-oncogene c-Fyn;Src-like kinase;p59-Fyn -FYN_HUMAN P06241 SLK (NetworKIN) SLK Fyn SLK_group 2.7.10.2 FYN EC 2.7.10.2;SLK;Tyrosine-protein kinase Fyn;Proto-oncogene Syn;Proto-oncogene c-Fyn;Src-like kinase;p59-Fyn -FYV1_HUMAN Q9Y2I7 PIKFYVE (PSP) PIKFYVE 2.7.1.150;2.7.11.1 PIKFYVE;KIAA0981;PIP5K3 2.7.11.1;1-phosphatidylinositol 3-phosphate 5-kinase;Phosphatidylinositol 3-phosphate 5-kinase;2.7.1.150;FYVE finger-containing phosphoinositide kinase;PIKfyve;Phosphatidylinositol 3-phosphate 5-kinase type III;PIPkin-III;Type III PIP kinase;Serine-protein kinase PIKFYVE -G6PI_HUMAN P06744 NLK NLK MAPK3_MAPK1_MAPK7_NLK_group 5.3.1.9 GPI Glucose-6-phosphate isomerase;GPI;5.3.1.9;Autocrine motility factor;AMF;Neuroleukin;NLK;Phosphoglucose isomerase;PGI;Phosphohexose isomerase;PHI;Sperm antigen 36;SA-36 -GAK_HUMAN O14976 GAK (PSP) GAK 2.7.11.1 GAK EC 2.7.11.1;Cyclin-G-associated kinase -GRK1_HUMAN Q15835 GRK-1 GRK1 GRK1 GRK_group 2.7.11.14 GRK1;RHOK 2.7.11.14;RK;Rhodopsin kinase GRK1;G protein-coupled receptor kinase 1 -GRK4_HUMAN P32298 GRK-4 GRK4 GRK4 GRK_group 2.7.11.16 GRK4;GPRK2L;GPRK4 EC 2.7.11.16;G protein-coupled receptor kinase 4;G protein-coupled receptor kinase GRK4;ITI1 -GRK5_HUMAN P34947 GRK-5 GRK5 GRK5 GRK_group 2.7.11.16 GRK5;GPRK5 EC 2.7.11.16;G protein-coupled receptor kinase 5;G protein-coupled receptor kinase GRK5 -GRK6_HUMAN P43250 GRK-6 GRK6 GRK6 GRK_group 2.7.11.16 GRK6;GPRK6 G protein-coupled receptor kinase 6;EC 2.7.11.16;G protein-coupled receptor kinase GRK6;Isoform GRK6C of G protein-coupled receptor kinase 6 -GRK7_HUMAN Q8WTQ7 GRK_group GRK7 GRK7 GRK_group 2.7.11.14 GRK7;GPRK7 Rhodopsin kinase GRK7;2.7.11.14;G protein-coupled receptor kinase 7;G protein-coupled receptor kinase GRK7 -GSK3A_HUMAN P49840 GSK-3_alpha GSK3alpha GSK3A GSK3_group 2.7.11.1;2.7.11.26 GSK3A 2.7.11.1;EC 2.7.11.26;Glycogen synthase kinase-3 alpha;GSK-3 alpha;Serine/threonine-protein kinase GSK3A -GSK3B P49841-2 GSK3B iso2 (PSP) GSK3B iso2 GSK3B 2.7.11.1;GSK-3 beta;2.7.11.26;Serine/threonine-protein kinase GSK3B;Isoform 2 of Glycogen synthase kinase-3 beta -GSK3B_HUMAN P49841 GSK-3_beta GSK3beta GSK3B GSK3_group 2.7.11.1;2.7.11.26 GSK3B 2.7.11.1;Glycogen synthase kinase-3 beta;GSK-3 beta;2.7.11.26;Serine/threonine-protein kinase GSK3B -GWL_HUMAN Q96GX5 MASTL (PSP) MASTL 2.7.11.1 MASTL;GW;GWL;THC2 EC 2.7.11.1;GW;GWL;Serine/threonine-protein kinase greatwall;hGWL;Microtubule-associated serine/threonine-protein kinase-like;MAST-L;Isoform 3 of Serine/threonine-protein kinase greatwall -HASP_HUMAN Q8TF76 Haspin (NetworKIN) Haspin Haspin Haspin 2.7.11.1 HASPIN;GSG2 2.7.11.1;Serine/threonine-protein kinase haspin;Germ cell-specific gene 2 protein;H-haspin;Haploid germ cell-specific nuclear protein kinase -HCK_HUMAN P08631 HCK HCK Hck Src_group 2.7.10.2 HCK EC 2.7.10.2;Tyrosine-protein kinase HCK;Hematopoietic cell kinase;Hemopoietic cell kinase;p59-HCK/p60-HCK;p59Hck;p61Hck;Isoform 3 of Tyrosine-protein kinase HCK -HIPK1_HUMAN Q86Z02 HIPK1 HIPK1 HIPK1 HIPK1_HIPK2_group 2.7.11.1 HIPK1;KIAA0630;MYAK;NBAK2 EC 2.7.11.1;Homeodomain-interacting protein kinase 1;Nuclear body-associated kinase 2;Isoform 3 of Homeodomain-interacting protein kinase 1 -HIPK2_HUMAN Q9H2X6 HIPK2 HIPK2 HIPK2 HIPK1_HIPK2_group 2.7.11.1 HIPK2 EC 2.7.11.1;Homeodomain-interacting protein kinase 2;hHIPk2;Isoform 3 of Homeodomain-interacting protein kinase 2 -HIPK3_HUMAN Q9H422 HIPK3 HIPK3 HIPK3 2.7.11.1 HIPK3;DYRK6;FIST3;PKY EC 2.7.11.1;Homeodomain-interacting protein kinase 3;Androgen receptor-interacting nuclear protein kinase;ANPK;Fas-interacting serine/threonine-protein kinase;FIST;Homolog of protein kinase YAK1 -HUNK_HUMAN P57058 HUNK (PSP) HUNK 2.7.11.1 HUNK;MAKV EC 2.7.11.1;Hormonally up-regulated neu tumor-associated kinase;B19;Serine/threonine-protein kinase MAK-V -IGF1R_HUMAN P08069 IGF1R IGF1R IGF1R InsR_group 2.7.10.1 IGF1R EC 2.7.10.1;Insulin-like growth factor 1 receptor;Insulin-like growth factor I receptor;IGF-I receptor;CD221;Insulin-like growth factor 1 receptor alpha chain;Insulin-like growth factor 1 receptor beta chain -IKKA_HUMAN O15111 IKK_alpha IKKalpha IKKA IKKalpha_IKKbeta_group 2.7.11.10 CHUK;IKKA;TCF16 Inhibitor of nuclear factor kappa-B kinase subunit alpha;I-kappa-B kinase alpha;IKK-A;IKK-alpha;IkBKA;IkappaB kinase;2.7.11.10;Conserved helix-loop-helix ubiquitous kinase;I-kappa-B kinase 1;IKK1;Nuclear factor NF-kappa-B inhibitor kinase alpha;NFKBIKA;Transcription factor 16;TCF-16 -IKKB_HUMAN O14920 IKK_beta IKKbeta IKKB IKKalpha_IKKbeta_group 2.7.11.1;2.7.11.10 IKBKB;IKKB 2.7.11.1;Inhibitor of nuclear factor kappa-B kinase subunit beta;I-kappa-B-kinase beta;IKK-B;IKK-beta;IkBKB;EC 2.7.11.10;I-kappa-B kinase 2;IKK2;Nuclear factor NF-kappa-B inhibitor kinase beta;NFKBIKB;Serine/threonine protein kinase IKBKB;Isoform 3 of Inhibitor of nuclear factor kappa-B kinase subunit beta -IKKE_HUMAN Q14164 IKK_epsilon IKK_epsilon IKKE 2.7.11.10 IKBKE;IKKE;IKKI;KIAA0151 EC 2.7.11.10;Inhibitor of nuclear factor kappa-B kinase subunit epsilon;I-kappa-B kinase epsilon;IKK-E;IKK-epsilon;IkBKE;Inducible I kappa-B kinase;IKK-i;Isoform 2 of Inhibitor of nuclear factor kappa-B kinase subunit epsilon -ILK_HUMAN Q13418 ILK ILK ILK 2.7.11.1 ILK;ILK1;ILK2 2.7.11.1;Integrin-linked protein kinase;59 kDa serine/threonine-protein kinase;Beta-integrin-linked kinase;ILK-1;ILK-2;p59ILK -INSRR_HUMAN P14616 IRR (NetworKIN) IRR InsR_group 2.7.10.1 INSRR;IRR EC 2.7.10.1;IRR;Insulin receptor-related protein;IR-related receptor;Insulin receptor-related protein alpha chain;Insulin receptor-related protein beta chain -INSR_HUMAN P06213 INSR INSR INSR 2.7.10.1 INSR EC 2.7.10.1;Insulin receptor;IR;CD220;Insulin receptor subunit alpha;Insulin receptor subunit beta;Isoform Short of Insulin receptor -INSR_HUMAN P06213 InsR (NetworKIN) InsR INSR InsR_group 2.7.10.1 INSR EC 2.7.10.1;Insulin receptor;IR;CD220;Insulin receptor subunit alpha;Insulin receptor subunit beta;Isoform Short of Insulin receptor -IRAK1_HUMAN P51617 IRAK1 IRAK1 IRAK1 2.7.11.1 IRAK1;IRAK EC 2.7.11.1;Interleukin-1 receptor-associated kinase 1;IRAK-1;Isoform 3 of Interleukin-1 receptor-associated kinase 1 -IRAK4_HUMAN Q9NWZ3 IRAK4 IRAK4 IRAK4 2.7.11.1 IRAK4 EC 2.7.11.1;Interleukin-1 receptor-associated kinase 4;IRAK-4;Renal carcinoma antigen NY-REN-64;Isoform 2 of Interleukin-1 receptor-associated kinase 4 -ITK_HUMAN Q08881 ITK ITK ITK Tec_group 2.7.10.2 EMT;ITK;LYK EC 2.7.10.2;Tyrosine-protein kinase ITK/TSK;Interleukin-2-inducible T-cell kinase;IL-2-inducible T-cell kinase;Kinase EMT;T-cell-specific kinase;Tyrosine-protein kinase Lyk -JAK1_HUMAN P23458 JAK1 JAK1 JAK1 2.7.10.2 JAK1;JAK1A;JAK1B 2.7.10.2;Tyrosine-protein kinase JAK1;Janus kinase 1;JAK-1 -JAK2_HUMAN O60674 JAK2 JAK2 JAK2 2.7.10.2 JAK2 2.7.10.2;Tyrosine-protein kinase JAK2;Janus kinase 2;JAK-2 -JAK3_HUMAN P52333 JAK3 JAK3 JAK3 2.7.10.2 JAK3 EC 2.7.10.2;Tyrosine-protein kinase JAK3;Janus kinase 3;JAK-3;Leukocyte janus kinase;L-JAK;Isoform 3 of Tyrosine-protein kinase JAK3 -JMJD6_HUMAN Q6NYC1 JMJD6 (PSP) JMJD6 JMJD6;KIAA0585;PSR;PTDSR 1.14.11.-;Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;Histone arginine demethylase JMJD6;JmjC domain-containing protein 6;Jumonji domain-containing protein 6;Lysyl-hydroxylase JMJD6;Peptide-lysine 5-dioxygenase JMJD6;Phosphatidylserine receptor;Protein PTDSR -KAPCA_HUMAN P17612 PKA_alpha PKAalpha PKACA iso2 PKA_group 2.7.11.11 PRKACA;PKACA EC 2.7.11.11;cAMP-dependent protein kinase catalytic subunit alpha;PKA C-alpha;Isoform 2 of cAMP-dependent protein kinase catalytic subunit alpha -KAPCB_HUMAN P22694 PKA_group PKAbeta PKACB PKA_group 2.7.11.11 PRKACB EC 2.7.11.11;cAMP-dependent protein kinase catalytic subunit beta;PKA C-beta -KAPCG_HUMAN P22612 PKA_group PKAgamma PKA_group 2.7.11.11 PRKACG cAMP-dependent protein kinase catalytic subunit gamma;PKA C-gamma;EC 2.7.11.11 -KC1AL_HUMAN Q8N752 CK1alpha2 (NetworKIN) CK1alpha2 CK1A2 CK1_group 2.7.11.1 CSNK1A1L EC 2.7.11.1;CK1;Casein kinase I isoform alpha-like;CKI-alpha-like -KC1A_HUMAN P48729 CK1_alpha CK1alpha CK1A CK1_group 2.7.11.1 CSNK1A1 EC 2.7.11.1;Casein kinase I isoform alpha;CKI-alpha;CK1;Isoform 2 of Casein kinase I isoform alpha -KC1D_HUMAN P48730 CK1_delta CK1delta CK1D CK1_group 2.7.11.1;2.7.11.26 CSNK1D;HCKID 2.7.11.1;2.7.11.26;Casein kinase I isoform delta;CKI-delta;CKId;Tau-protein kinase CSNK1D;Isoform 2 of Casein kinase I isoform delta -KC1E_HUMAN P49674 CK1_epsilon CK1epsilon CK1E CK1_group 2.7.11.1 CSNK1E 2.7.11.1;Casein kinase I isoform epsilon;CKI-epsilon;CKIe -KC1G1_HUMAN Q9HCP0 CK1_group CK1gamma1 CK1G1 CK1_group 2.7.11.1 CSNK1G1 EC 2.7.11.1;Casein kinase I isoform gamma-1;CKI-gamma 1;Isoform 1S of Casein kinase I isoform gamma-1 -KC1G2_HUMAN P78368 CK1_group CK1gamma2 CK1G2 CK1_group 2.7.11.1 CSNK1G2;CK1G2 EC 2.7.11.1;Casein kinase I isoform gamma-2;CKI-gamma 2 -KC1G3_HUMAN Q9Y6M4 CK1_group CK1gamma3 CK1G3 CK1_group 2.7.11.1 CSNK1G3 EC 2.7.11.1;Casein kinase I isoform gamma-3;CKI-gamma 3;Isoform 2 of Casein kinase I isoform gamma-3 -KCC1A_HUMAN Q14012 CaM-KI_alpha CaMKIalpha CAMK1A CaMKI_group 2.7.11.17 CAMK1 EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type 1;CaM kinase I;CaM-KI;CaM kinase I alpha;CaMKI-alpha -KCC1B_HUMAN Q6P2M8 CAMK1B (PSP) CAMK1B 2.7.11.17 PNCK EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type 1B;CaM kinase I beta;CaM kinase IB;CaM-KI beta;CaMKI-beta;Pregnancy up-regulated non-ubiquitously-expressed CaM kinase;Isoform 3 of Calcium/calmodulin-dependent protein kinase type 1B -KCC1D_HUMAN Q8IU85 CaM-KI_group CaMKIdelta CaMKI_group 2.7.11.17 CAMK1D;CAMKID EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type 1D;CaM kinase I delta;CaM kinase ID;CaM-KI delta;CaMKI delta;CaMKID;CaMKI-like protein kinase;CKLiK -KCC1G_HUMAN Q96NX5 CaM-KI_group CaMKIgamma CAMK1G CaMKI_group 2.7.11.17 CAMK1G;CLICK3;VWS1 EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type 1G;CaM kinase I gamma;CaM kinase IG;CaM-KI gamma;CaMKI gamma;CaMKIG;CaMK-like CREB kinase III;CLICK III;Isoform 2 of Calcium/calmodulin-dependent protein kinase type 1G -KCC2A_HUMAN Q9UQM7 CaM-KII_alpha CaMKIIalpha CAMK2A CaMKII_group 2.7.11.17 CAMK2A;CAMKA;KIAA0968 Calcium/calmodulin-dependent protein kinase type II subunit alpha;CaM kinase II subunit alpha;CaMK-II subunit alpha;2.7.11.17 -KCC2B_HUMAN Q13554 CaMKIIbeta (NetworKIN) CaMKIIbeta CAMK2B CaMKII_group 2.7.11.17 CAM2;CAMK2B;CAMK2;CAMKB EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type II subunit beta;CaM kinase II subunit beta;CaMK-II subunit beta -KCC2D Q13557-8 CAMK2D iso8 (PSP) CAMK2D iso8 CAMK2D;CAMKD EC 2.7.11.17;CaM kinase II subunit delta;CaMK-II subunit delta;Isoform Delta 3 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 4 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 8 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 9 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 6 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 7 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 11 of Calcium/calmodulin-dependent protein kinase type II subunit delta;Isoform Delta 12 of Calcium/calmodulin-dependent protein kinase type II subunit delta -KCC2D_HUMAN Q13557 CaM-KII_delta CaMKIIdelta CAMK2D CaMKII_group 2.7.11.17 CAMK2D;CAMKD EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type II subunit delta;CaM kinase II subunit delta;CaMK-II subunit delta;Isoform Delta 10 of Calcium/calmodulin-dependent protein kinase type II subunit delta -KCC2G_HUMAN Q13555 CaM-KII_group CaMKIIgamma CAMK2G CaMKII_group 2.7.11.17 CAMK2G;CAMK;CAMK-II;CAMKG EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type II subunit gamma;CaM kinase II subunit gamma;CaMK-II subunit gamma -KCC4_HUMAN Q16566 CaM-KIV CaMKIV CAMK4 CaMKIV 2.7.11.17 CAMK;CAMK4;CAMK-GR;CAMKIV EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase type IV;CaMK IV;CaM kinase-GR -KGP1 Q13976-2 PKG1 iso2 (PSP) PKG1 iso2 PRKG1;PRKG1B;PRKGR1A;PRKGR1B EC 2.7.11.12;cGK 1;cGK1;cGMP-dependent protein kinase I;cGKI;Isoform Beta of cGMP-dependent protein kinase 1 -KGP1_HUMAN Q13976 PKG1/cGK-I PKG1cGKI PKG1 PKGcGK_group 2.7.11.12 PRKG1;PRKG1B;PRKGR1A;PRKGR1B EC 2.7.11.12;cGMP-dependent protein kinase 1;cGK 1;cGK1;cGMP-dependent protein kinase I;cGKI;Isoform 3 of cGMP-dependent protein kinase 1 -KGP2_HUMAN Q13237 PKG2/cGK-II PKG2cGKII PKG2 PKGcGK_group 2.7.11.12 PRKG2;PRKGR2 cGMP-dependent protein kinase 2;cGK 2;cGK2;EC 2.7.11.12;cGMP-dependent protein kinase II;cGKII;Isoform 2 of cGMP-dependent protein kinase 2 -KIT_HUMAN P10721 Kit Kit Kit FLT3_CSF1R_Kit_PDGFR_group 2.7.10.1 KIT;SCFR EC 2.7.10.1;SCFR;Mast/stem cell growth factor receptor Kit;Piebald trait protein;PBT;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;p145 c-kit;v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog;CD117 -KKCC1_HUMAN Q8N5S9 CaM-KK_alpha CaM-KK_alpha CAMKK1 2.7.11.17 CAMKK1;CAMKKA Calcium/calmodulin-dependent protein kinase kinase 1;CaM-KK 1;CaM-kinase kinase 1;CaMKK 1;EC 2.7.11.17;CaM-kinase IV kinase;Calcium/calmodulin-dependent protein kinase kinase alpha;CaM-KK alpha;CaM-kinase kinase alpha;CaMKK alpha -KKCC2_HUMAN Q96RR4 CAMKK2 (PSP) CAMKK2 2.7.11.17 CAMKK2;CAMKKB;KIAA0787 EC 2.7.11.17;Calcium/calmodulin-dependent protein kinase kinase 2;CaM-KK 2;CaM-kinase kinase 2;CaMKK 2;Calcium/calmodulin-dependent protein kinase kinase beta;CaM-KK beta;CaM-kinase kinase beta;CaMKK beta;Isoform 5 of Calcium/calmodulin-dependent protein kinase kinase 2 -KPB1_HUMAN P46020 PHKA1 (PSP) PHKA1 PHKA1;PHKA Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform;Phosphorylase kinase alpha M subunit -KPCA_HUMAN P17252 PKC_alpha PKCalpha PKCA PKC_group 2.7.11.13 PRKACA;PRKCA;PKCA EC 2.7.11.13;Protein kinase C alpha type;PKC-A;PKC-alpha -KPCB_HUMAN P05771 PKC_beta PKCbeta PKCB iso2 PKC_group 2.7.11.13 PRKCB;PKCB;PRKCB1 2.7.11.13;Protein kinase C beta type;PKC-B;PKC-beta;Isoform Beta-II of Protein kinase C beta type -KPCD1_HUMAN Q15139 PKD1 PKD1 PRKD1 PKD_group 2.7.11.13 PRKD1;PKD;PKD1;PRKCM EC 2.7.11.13;Serine/threonine-protein kinase D1;Protein kinase C mu type;Protein kinase D;nPKC-D1;nPKC-mu -KPCD2_HUMAN Q9BZL6 PKD2 PKD2 PRKD2 PKD_group 2.7.11.13 PRKD2;PKD2;HSPC187 2.7.11.13;Serine/threonine-protein kinase D2;nPKC-D2;Isoform 3 of Serine/threonine-protein kinase D2 -KPCD3_HUMAN O94806 PKD3 (NetworKIN) PKD3 PRKD3 PKD_group 2.7.11.13 PRKD3;EPK2;PRKCN Serine/threonine-protein kinase D3;EC 2.7.11.13;Protein kinase C nu type;Protein kinase EPK2;nPKC-nu -KPCD_HUMAN Q05655 PKC_delta PKCdelta PKCD PKC_group 2.7.10.2;2.7.11.13 PRKCD;PKCD 2.7.11.13;EC 2.7.10.2;Protein kinase C delta type;Tyrosine-protein kinase PRKCD;nPKC-delta;Protein kinase C delta type regulatory subunit;Protein kinase C delta type catalytic subunit;Sphingosine-dependent protein kinase-1;SDK1 -KPCE_HUMAN Q02156 PKC_epsilon PKCepsilon PKCE PKC_group 2.7.11.13 PRKCE;PKCE 2.7.11.13;Protein kinase C epsilon type;nPKC-epsilon -KPCG_HUMAN P05129 PKC_gamma PKCgamma PKCG PKC_group 2.7.11.13 PRKCG;PKCG EC 2.7.11.13;Protein kinase C gamma type;PKC-gamma;Isoform 2 of Protein kinase C gamma type -KPCI_HUMAN P41743 PKC_iota PKCiota PKCI PKC_group 2.7.11.13 PRKCI;DXS1179E EC 2.7.11.13;Protein kinase C iota type;Atypical protein kinase C-lambda/iota;PRKC-lambda/iota;aPKC-lambda/iota;nPKC-iota -KPCL_HUMAN P24723 PKC_eta PKCeta PKCH PKC_group 2.7.11.13 PRKCH;PKCL;PRKCL Protein kinase C eta type;2.7.11.13;PKC-L;nPKC-eta;Isoform 2 of Protein kinase C eta type -KPCT_HUMAN Q04759 PKC_theta PKCtheta PKCT PKC_group 2.7.11.13 PRKCQ;PRKCT 2.7.11.13;Protein kinase C theta type;nPKC-theta;Isoform 2 of Protein kinase C theta type -KPCZ_HUMAN Q05513 PKC_zeta PKCzeta PKCZ PKC_group 2.7.11.13 PRKCZ;PKC2 2.7.11.13;Protein kinase C zeta type;nPKC-zeta;Isoform 2 of Protein kinase C zeta type -KPYM_HUMAN P14618 PKM (PSP) PKM 2.7.1.40;2.7.10.2;2.7.11.1 PKM;OIP3;PK2;PK3;PKM2 2.7.11.1;Pyruvate kinase PKM;2.7.1.40;Cytosolic thyroid hormone-binding protein;CTHBP;Opa-interacting protein 3;OIP-3;Pyruvate kinase 2/3;Pyruvate kinase muscle isozyme;Threonine-protein kinase PKM2;Thyroid hormone-binding protein 1;THBP1;Tumor M2-PK;Tyrosine-protein kinase PKM2;2.7.10.2;p58;Isoform 3 of Pyruvate kinase PKM -KS6A1_HUMAN Q15418 RSK-1 RSK-1 p90RSK 2.7.11.1 RPS6KA1;MAPKAPK1A;RSK1 EC 2.7.11.1;Ribosomal protein S6 kinase alpha-1;S6K-alpha-1;90 kDa ribosomal protein S6 kinase 1;p90-RSK 1;p90RSK1;p90S6K;MAP kinase-activated protein kinase 1a;MAPK-activated protein kinase 1a;MAPKAP kinase 1a;MAPKAPK-1a;Ribosomal S6 kinase 1;RSK-1 -KS6A2_HUMAN Q15349 RSK-3 RSK3 RSK3 RSK_group 2.7.11.1 RPS6KA2;MAPKAPK1C;RSK3 EC 2.7.11.1;Ribosomal protein S6 kinase alpha-2;S6K-alpha-2;90 kDa ribosomal protein S6 kinase 2;p90-RSK 2;p90RSK2;MAP kinase-activated protein kinase 1c;MAPK-activated protein kinase 1c;MAPKAP kinase 1c;MAPKAPK-1c;Ribosomal S6 kinase 3;RSK-3;pp90RSK3 -KS6A3_HUMAN P51812 RSK-2 RSK2 RSK2 RSK_group 2.7.11.1 RPS6KA3;ISPK1;MAPKAPK1B;RSK2 2.7.11.1;Ribosomal protein S6 kinase alpha-3;S6K-alpha-3;90 kDa ribosomal protein S6 kinase 3;p90-RSK 3;p90RSK3;Insulin-stimulated protein kinase 1;ISPK-1;MAP kinase-activated protein kinase 1b;MAPK-activated protein kinase 1b;MAPKAP kinase 1b;MAPKAPK-1b;Ribosomal S6 kinase 2;RSK-2;pp90RSK2 -KS6A4_HUMAN O75676 MSK2 (PSP) MSK2 2.7.11.1 RPS6KA4;MSK2 EC 2.7.11.1;Ribosomal protein S6 kinase alpha-4;S6K-alpha-4;90 kDa ribosomal protein S6 kinase 4;Nuclear mitogen- and stress-activated protein kinase 2;Ribosomal protein kinase B;RSKB -KS6A5_HUMAN O75582 RSK-5 RSK-5 MSK1 2.7.11.1 RPS6KA5;MSK1 EC 2.7.11.1;Ribosomal protein S6 kinase alpha-5;S6K-alpha-5;90 kDa ribosomal protein S6 kinase 5;Nuclear mitogen- and stress-activated protein kinase 1;RSK-like protein kinase;RSKL -KS6B1 P23443-2 p70S6K iso2 (PSP) p70S6K iso2 RPS6KB1;STK14A 2.7.11.1;S6K-beta-1;S6K1;70 kDa ribosomal protein S6 kinase 1;P70S6K1;p70-S6K 1;Ribosomal protein S6 kinase I;Serine/threonine-protein kinase 14A;p70 ribosomal S6 kinase alpha;p70 S6 kinase alpha;p70 S6K-alpha;p70 S6KA;Isoform Alpha II of Ribosomal protein S6 kinase beta-1;Isoform 2 of Ribosomal protein S6 kinase beta-1;Isoform 3 of Ribosomal protein S6 kinase beta-1 -KS6B1_HUMAN P23443 p70S6K p70S6K p70S6K p70S6K_group 2.7.11.1 RPS6KB1;STK14A 2.7.11.1;Ribosomal protein S6 kinase beta-1;S6K-beta-1;S6K1;70 kDa ribosomal protein S6 kinase 1;P70S6K1;p70-S6K 1;Ribosomal protein S6 kinase I;Serine/threonine-protein kinase 14A;p70 ribosomal S6 kinase alpha;p70 S6 kinase alpha;p70 S6K-alpha;p70 S6KA;Isoform 4 of Ribosomal protein S6 kinase beta-1 -KS6B2_HUMAN Q9UBS0 p70S6Kb p70S6Kb P70S6KB p70S6K_group 2.7.11.1 RPS6KB2;STK14B EC 2.7.11.1;SRK;Ribosomal protein S6 kinase beta-2;S6K-beta-2;S6K2;70 kDa ribosomal protein S6 kinase 2;P70S6K2;p70-S6K 2;S6 kinase-related kinase;Serine/threonine-protein kinase 14B;p70 ribosomal S6 kinase beta;S6K-beta;p70 S6 kinase beta;p70 S6K-beta;p70 S6KB;p70-beta;Isoform 2 of Ribosomal protein S6 kinase beta-2 -KSR1_HUMAN Q8IVT5 KSR1 KSR1 KSR 2.7.11.1 KSR1;KSR 2.7.11.1;Kinase suppressor of Ras 1;Isoform 4 of Kinase suppressor of Ras 1 -KSYK_HUMAN P43405 SYK SYK Syk 2.7.10.2 SYK 2.7.10.2;Tyrosine-protein kinase SYK;Spleen tyrosine kinase;p72-Syk;Isoform Short of Tyrosine-protein kinase SYK -LATS1_HUMAN O95835 LATS1 (PSP) LATS1 2.7.11.1 LATS1;WARTS 2.7.11.1;Serine/threonine-protein kinase LATS1;Large tumor suppressor homolog 1;WARTS protein kinase;h-warts -LATS2_HUMAN Q9NRM7 LATS2 (PSP) LATS2 2.7.11.1 LATS2;KPM EC 2.7.11.1;Serine/threonine-protein kinase LATS2;Kinase phosphorylated during mitosis protein;Large tumor suppressor homolog 2;Serine/threonine-protein kinase kpm;Warts-like kinase -LCK_HUMAN P06239 Lck Lck Lck Src_group 2.7.10.2 LCK EC 2.7.10.2;Tyrosine-protein kinase Lck;Leukocyte C-terminal Src kinase;LSK;Lymphocyte cell-specific protein-tyrosine kinase;Protein YT16;Proto-oncogene Lck;T cell-specific protein-tyrosine kinase;p56-LCK;Isoform 3 of Tyrosine-protein kinase Lck -LIMK1_HUMAN P53667 LIMK1 LIMK1 LIMK1 2.7.11.1 LIMK1;LIMK 2.7.11.1;LIM domain kinase 1;LIMK-1;Isoform 2 of LIM domain kinase 1 -LIMK2_HUMAN P53671 LIMK2 LIMK2 LIMK2 2.7.11.1 LIMK2 2.7.11.1;LIM domain kinase 2;LIMK-2;Isoform 3 of LIM domain kinase 2 -LMTK2_HUMAN Q8IWU2 Lmr2 (PSP) Lmr2 2.7.11.1 LMTK2;AATYK2;BREK;KIAA1079;KPI2;LMR2 EC 2.7.11.1;Serine/threonine-protein kinase LMTK2;Apoptosis-associated tyrosine kinase 2;Brain-enriched kinase;hBREK;CDK5/p35-regulated kinase;CPRK;Kinase/phosphatase/inhibitor 2;Lemur tyrosine kinase 2;Serine/threonine-protein kinase KPI-2 -LRRK1_HUMAN Q38SD2 LRRK1 (PSP) LRRK1 2.7.11.1 LRRK1;KIAA1790 Leucine-rich repeat serine/threonine-protein kinase 1;EC 2.7.11.1;Isoform 2 of Leucine-rich repeat serine/threonine-protein kinase 1 -LRRK2_HUMAN Q5S007 LRRK2 LRRK2 LRRK2 2.7.11.1 LRRK2;PARK8 2.7.11.1;3.6.5.-;Leucine-rich repeat serine/threonine-protein kinase 2;Dardarin -LTK_HUMAN P29376 LTK (PSP) LTK 2.7.10.1 LTK;TYK1 2.7.10.1;Leukocyte tyrosine kinase receptor;Protein tyrosine kinase 1 -LYN_HUMAN P07948 Lyn Lyn LYN Src_group 2.7.10.2 LYN;JTK8 EC 2.7.10.2;Tyrosine-protein kinase Lyn;Lck/Yes-related novel protein tyrosine kinase;V-yes-1 Yamaguchi sarcoma viral related oncogene homolog;p53Lyn;p56Lyn -M3K10_HUMAN Q02779 MLK2 (PSP) MLK2 2.7.11.25 MST;MAP3K10;MLK2 EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 10;Mixed lineage kinase 2;Protein kinase MST -M3K11_HUMAN Q16584 MAP3K11 MAP3K11 MLK3 2.7.11.25 MAP3K11;MLK3;PTK1;SPRK EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 11;Mixed lineage kinase 3;Src-homology 3 domain-containing proline-rich kinase;Isoform 2 of Mitogen-activated protein kinase kinase kinase 11 -M3K12_HUMAN Q12852 DLK (PSP) DLK 2.7.11.25 MAP3K12;ZPK Mixed lineage kinase;2.7.11.25;DLK;ZPK;Mitogen-activated protein kinase kinase kinase 12;Dual leucine zipper bearing kinase;Leucine-zipper protein kinase;MAPK-upstream kinase;MUK;Isoform 2 of Mitogen-activated protein kinase kinase kinase 12 -M3K13_HUMAN O43283 LZK (PSP) LZK 2.7.11.25 MAP3K13;LZK EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 13;Leucine zipper-bearing kinase;Mixed lineage kinase;MLK;Isoform 5 of Mitogen-activated protein kinase kinase kinase 13 -M3K14_HUMAN Q99558 MAP3K14 MAP3K14 Nik 2.7.11.25 MAP3K14;NIK EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 14;NF-kappa-beta-inducing kinase;HsNIK;Serine/threonine-protein kinase NIK -M3K1_HUMAN Q13233 MAP3K1 MAP3K1 MEKK1 2.7.11.25 MAP3K1;MAPKKK1;MEKK;MEKK1 EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 1;MAPK/ERK kinase kinase 1;MEK kinase 1;MEKK 1 -M3K20_HUMAN Q9NYL2 ZAK (PSP) ZAK 2.7.11.25 MAP3K20;MLTK;HCCS4 EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 20;Human cervical cancer suppressor gene 4 protein;HCCS-4;Leucine zipper- and sterile alpha motif-containing kinase;MLK-like mitogen-activated protein triple kinase;Mitogen-activated protein kinase kinase kinase MLT;Mixed lineage kinase-related kinase;MLK-related kinase;MRK;Sterile alpha motif- and leucine zipper-containing kinase AZK;Isoform 2 of Mitogen-activated protein kinase kinase kinase 20 -M3K2_HUMAN Q9Y2U5 MEKK2 (PSP) MEKK2 2.7.11.25 MAP3K2;MAPKKK2;MEKK2 Mitogen-activated protein kinase kinase kinase 2;EC 2.7.11.25;MAPK/ERK kinase kinase 2;MEK kinase 2;MEKK 2 -M3K3_HUMAN Q99759 MEKK3 (PSP) MEKK3 2.7.11.25 MAP3K3;MAPKKK3;MEKK3 EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 3;MAPK/ERK kinase kinase 3;MEK kinase 3;MEKK 3;Isoform 2 of Mitogen-activated protein kinase kinase kinase 3 -M3K4_HUMAN Q9Y6R4 MEKK4 (PSP) MEKK4 2.7.11.25 MAP3K4;KIAA0213;MAPKKK4;MEKK4;MTK1 EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 4;MAP three kinase 1;MAPK/ERK kinase kinase 4;MEK kinase 4;MEKK 4;Isoform 2 of Mitogen-activated protein kinase kinase kinase 4 -M3K5_HUMAN Q99683 MAP3K5 MAP3K5 ASK1 2.7.11.25 MAP3K5;ASK1;MAPKKK5;MEKK5 Mitogen-activated protein kinase kinase kinase 5;2.7.11.25;Apoptosis signal-regulating kinase 1;ASK-1;MAPK/ERK kinase kinase 5;MEK kinase 5;MEKK 5 -M3K6_HUMAN O95382 MEKK6 (PSP) MEKK6 2.7.11.25 MAP3K6;ASK2;MAPKKK6;MEKK6 EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 6;Apoptosis signal-regulating kinase 2 -M3K7_HUMAN O43318 MAP3K7 MAP3K7 TAK1 2.7.11.25 TAK1;MAP3K7 2.7.11.25;Mitogen-activated protein kinase kinase kinase 7;Transforming growth factor-beta-activated kinase 1;TGF-beta-activated kinase 1;Isoform 1C of Mitogen-activated protein kinase kinase kinase 7 -M3K8_HUMAN P41279 MAP3K8 MAP3K8 Cot 2.7.11.25 COT;MAP3K8;ESTF EC 2.7.11.25;Mitogen-activated protein kinase kinase kinase 8;Cancer Osaka thyroid oncogene;Proto-oncogene c-Cot;Serine/threonine-protein kinase cot;Tumor progression locus 2;TPL-2;Isoform 2 of Mitogen-activated protein kinase kinase kinase 8 -M4K1_HUMAN Q92918 MAP4K1 MAP4K1 HPK1 2.7.11.1 MAP4K1;HPK1 Mitogen-activated protein kinase kinase kinase kinase 1;2.7.11.1;Hematopoietic progenitor kinase;MAPK/ERK kinase kinase kinase 1;MEK kinase kinase 1;MEKKK 1 -M4K2_HUMAN Q12851 MAP4K2 MAP4K2 GCK 2.7.11.1 MAP4K2;GCK;RAB8IP EC 2.7.11.1;Mitogen-activated protein kinase kinase kinase kinase 2;B lymphocyte serine/threonine-protein kinase;Germinal center kinase;GC kinase;MAPK/ERK kinase kinase kinase 2;MEK kinase kinase 2;MEKKK 2;Rab8-interacting protein;Isoform 2 of Mitogen-activated protein kinase kinase kinase kinase 2 -M4K3_HUMAN Q8IVH8 KHS2 (PSP) KHS2 2.7.11.1 MAP4K3;RAB8IPL1 EC 2.7.11.1;Mitogen-activated protein kinase kinase kinase kinase 3;Germinal center kinase-related protein kinase;GLK;MAPK/ERK kinase kinase kinase 3;MEK kinase kinase 3;MEKKK 3 -M4K4_HUMAN O95819 MAP4K4 (NetworKIN) MAP4K4 HGK MSN_group 2.7.11.1 MAP4K4;HGK;KIAA0687;NIK EC 2.7.11.1;Mitogen-activated protein kinase kinase kinase kinase 4;HPK/GCK-like kinase HGK;MAPK/ERK kinase kinase kinase 4;MEK kinase kinase 4;MEKKK 4;Nck-interacting kinase;Isoform 2 of Mitogen-activated protein kinase kinase kinase kinase 4 -M4K5_HUMAN Q9Y4K4 KHS1 (PSP) KHS1 2.7.11.1 MAP4K5 EC 2.7.11.1;Mitogen-activated protein kinase kinase kinase kinase 5;Kinase homologous to SPS1/STE20;KHS;MAPK/ERK kinase kinase kinase 5;MEK kinase kinase 5;MEKKK 5 -MAK_HUMAN P20794 MAK (NetworKIN) MAK MAK RCK_group 2.7.11.1 MAK 2.7.11.1;Serine/threonine-protein kinase MAK;Male germ cell-associated kinase -MAPK2_HUMAN P49137 MAPKAPK2 MAPKAPK2 MAPKAPK2 2.7.11.1 MAPKAPK2 EC 2.7.11.1;MAP kinase-activated protein kinase 2;MAPK-activated protein kinase 2;MAPKAP kinase 2;MAPKAP-K2;MAPKAPK-2;MK-2;MK2;Isoform 2 of MAP kinase-activated protein kinase 2 -MAPK3_HUMAN Q16644 MAPK3 MAPK3 MAPKAPK3 MAPK3_MAPK1_MAPK7_NLK_group 2.7.11.1 MAPKAPK3 EC 2.7.11.1;MAP kinase-activated protein kinase 3;MAPK-activated protein kinase 3;MAPKAP kinase 3;MAPKAP-K3;MAPKAPK-3;MK-3;Chromosome 3p kinase;3pK -MAPK3_HUMAN Q16644 MAPKAPK3 (NetworKIN) MAPKAPK3 MAPKAPK3 MAPKAPK_group 2.7.11.1 MAPKAPK3 EC 2.7.11.1;MAP kinase-activated protein kinase 3;MAPK-activated protein kinase 3;MAPKAP kinase 3;MAPKAP-K3;MAPKAPK-3;MK-3;Chromosome 3p kinase;3pK -MAPK5_HUMAN Q8IW41 MAPKAPK5 MAPKAPK5 MAPKAPK5 MAPKAPK_group 2.7.11.1 MAPKAPK5;PRAK EC 2.7.11.1;PRAK;MAP kinase-activated protein kinase 5;MAPK-activated protein kinase 5;MAPKAP kinase 5;MAPKAP-K5;MAPKAPK-5;MK-5;MK5;p38-regulated/activated protein kinase;Isoform 2 of MAP kinase-activated protein kinase 5 -MARK1_HUMAN Q9P0L2 MARK1 (NetworKIN) MARK1 MARK1 MARK_group 2.7.11.1;2.7.11.26 MARK1;KIAA1477;MARK EC 2.7.11.1;EC 2.7.11.26;Serine/threonine-protein kinase MARK1;MAP/microtubule affinity-regulating kinase 1;PAR1 homolog c;Par-1c;Par1c -MARK2_HUMAN Q7KZI7 MARK2 (PSP) MARK2 2.7.11.1;2.7.11.26 MARK2;EMK1 EC 2.7.11.1;Serine/threonine-protein kinase MARK2;EC 2.7.11.26;ELKL motif kinase 1;EMK-1;MAP/microtubule affinity-regulating kinase 2;PAR1 homolog;PAR1 homolog b;Par-1b;Par1b;Isoform 2 of Serine/threonine-protein kinase MARK2 -MARK3 P27448-3 MARK3 iso3 (PSP) MARK3 iso3 MARK3;CTAK1;EMK2 EC 2.7.11.1;C-TAK1;cTAK1;Cdc25C-associated protein kinase 1;ELKL motif kinase 2;EMK-2;Protein kinase STK10;Ser/Thr protein kinase PAR-1;Par-1a;Serine/threonine-protein kinase p78;Isoform 2 of MAP/microtubule affinity-regulating kinase 3;Isoform 3 of MAP/microtubule affinity-regulating kinase 3;Isoform 5 of MAP/microtubule affinity-regulating kinase 3;Isoform 6 of MAP/microtubule affinity-regulating kinase 3;Isoform 7 of MAP/microtubule affinity-regulating kinase 3 -MARK3_HUMAN P27448 MARK3 (NetworKIN) MARK3 MARK3 MARK_group 2.7.11.1 MARK3;CTAK1;EMK2 EC 2.7.11.1;MAP/microtubule affinity-regulating kinase 3;C-TAK1;cTAK1;Cdc25C-associated protein kinase 1;ELKL motif kinase 2;EMK-2;Protein kinase STK10;Ser/Thr protein kinase PAR-1;Par-1a;Serine/threonine-protein kinase p78;Isoform 4 of MAP/microtubule affinity-regulating kinase 3 -MARK4_HUMAN Q96L34 MARK_group MARK4 MARK_group 2.7.11.1 MARK4;KIAA1860;MARKL1 2.7.11.1;MAP/microtubule affinity-regulating kinase 4;MAP/microtubule affinity-regulating kinase-like 1 -MAST3_HUMAN O60307 MAST3 (PSP) MAST3 2.7.11.1 MAST3;KIAA0561 EC 2.7.11.1;Microtubule-associated serine/threonine-protein kinase 3 -MATK_HUMAN P42679 CTK (PSP) CTK 2.7.10.2 MATK;CTK;HYL EC 2.7.10.2;CHK;Megakaryocyte-associated tyrosine-protein kinase;CSK homologous kinase;Hematopoietic consensus tyrosine-lacking kinase;Protein kinase HYL;Tyrosine-protein kinase CTK -MELK_HUMAN Q14680 Eg3 kinase Eg3 kinase MELK 2.7.10.2;2.7.11.1 MELK;KIAA0175 EC 2.7.11.1;EC 2.7.10.2;Maternal embryonic leucine zipper kinase;hMELK;Protein kinase Eg3;pEg3 kinase;Protein kinase PK38;hPK38;Tyrosine-protein kinase MELK;Isoform 3 of Maternal embryonic leucine zipper kinase -MERTK_HUMAN Q12866 Mer Mer Mer 2.7.10.1 MERTK;MER EC 2.7.10.1;Tyrosine-protein kinase Mer;Proto-oncogene c-Mer;Receptor tyrosine kinase MerTK -MET_HUMAN P08581 Met Met Met Met_group 2.7.10.1 MET EC 2.7.10.1;Hepatocyte growth factor receptor;HGF receptor;HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met -MINK1_HUMAN Q8N4C8 MAP4K6 (NetworKIN) MAP4K6 MINK MSN_group 2.7.11.1 MINK1;B55;MAP4K6;MINK;YSK2;ZC3 EC 2.7.11.1;Misshapen-like kinase 1;GCK family kinase MiNK;MAPK/ERK kinase kinase kinase 6;MEK kinase kinase 6;MEKKK 6;Misshapen/NIK-related kinase;Mitogen-activated protein kinase kinase kinase kinase 6;Isoform 4 of Misshapen-like kinase 1 -MK01_HUMAN P28482 MAPK1 MAPK1 ERK2 MAPK3_MAPK1_MAPK7_NLK_group 2.7.11.24 MAPK1;ERK2;PRKM1;PRKM2 EC 2.7.11.24;Mitogen-activated protein kinase 1;MAP kinase 1;MAPK 1;ERT1;Extracellular signal-regulated kinase 2;ERK-2;MAP kinase isoform p42;p42-MAPK;Mitogen-activated protein kinase 2;MAP kinase 2;MAPK 2 -MK03_HUMAN P27361 MAPK3 MAPK3 ERK1 MAPK3_MAPK1_MAPK7_NLK_group 2.7.11.24 MAPK3;ERK1;PRKM3 EC 2.7.11.24;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p44-ERK1;Isoform 3 of Mitogen-activated protein kinase 3 -MK04_HUMAN P31152 MAPK4 MAPK4 2.7.11.24 MAPK4;ERK4;PRKM4 EC 2.7.11.24;Mitogen-activated protein kinase 4;MAP kinase 4;MAPK 4;Extracellular signal-regulated kinase 4;ERK-4;MAP kinase isoform p63;p63-MAPK -MK06_HUMAN Q16659 MAPK6 MAPK6 ERK3 2.7.11.24 MAPK6;ERK3;PRKM6 EC 2.7.11.24;Mitogen-activated protein kinase 6;MAP kinase 6;MAPK 6;Extracellular signal-regulated kinase 3;ERK-3;MAP kinase isoform p97;p97-MAPK -MK07_HUMAN Q13164 MAPK7 MAPK7 ERK5 MAPK3_MAPK1_MAPK7_NLK_group 2.7.11.24 MAPK7;BMK1;ERK5;PRKM7 Mitogen-activated protein kinase 7;MAP kinase 7;MAPK 7;EC 2.7.11.24;Big MAP kinase 1;BMK-1;Extracellular signal-regulated kinase 5;ERK-5 -MK08 P45983-2 JNK1 iso2 (PSP) JNK1 iso2 MAPK8;JNK1;PRKM8;SAPK1;SAPK1C 2.7.11.24;MAP kinase 8;MAPK 8;JNK-46;Stress-activated protein kinase 1c;SAPK1c;Stress-activated protein kinase JNK1;c-Jun N-terminal kinase 1;Isoform 1 of Mitogen-activated protein kinase 8;Isoform 3 of Mitogen-activated protein kinase 8;Isoform 4 of Mitogen-activated protein kinase 8 -MK08_HUMAN P45983 MAPK8 MAPK8 JNK1 JNK_group 2.7.11.24 MAPK8;JNK1;PRKM8;SAPK1;SAPK1C 2.7.11.24;Mitogen-activated protein kinase 8;MAP kinase 8;MAPK 8;JNK-46;Stress-activated protein kinase 1c;SAPK1c;Stress-activated protein kinase JNK1;c-Jun N-terminal kinase 1;Isoform 5 of Mitogen-activated protein kinase 8 -MK09 P45984-2 JNK2 iso2 (PSP) JNK2 iso2 MAPK9;JNK2;PRKM9;SAPK1A MAP kinase 9;MAPK 9;2.7.11.24;JNK-55;Stress-activated protein kinase 1a;SAPK1a;Stress-activated protein kinase JNK2;c-Jun N-terminal kinase 2;Isoform Alpha-1 of Mitogen-activated protein kinase 9;Isoform Beta-1 of Mitogen-activated protein kinase 9;Isoform Beta-2 of Mitogen-activated protein kinase 9 -MK09_HUMAN P45984 MAPK9 MAPK9 JNK2 JNK_group 2.7.11.24 MAPK9;JNK2;PRKM9;SAPK1A Mitogen-activated protein kinase 9;MAP kinase 9;MAPK 9;2.7.11.24;JNK-55;Stress-activated protein kinase 1a;SAPK1a;Stress-activated protein kinase JNK2;c-Jun N-terminal kinase 2;Isoform 5 of Mitogen-activated protein kinase 9 -MK10_HUMAN P53779 MAPK10 MAPK10 JNK3 JNK_group 2.7.11.24 MAPK10;JNK3;JNK3A;PRKM10;SAPK1B EC 2.7.11.24;Mitogen-activated protein kinase 10;MAP kinase 10;MAPK 10;MAP kinase p49 3F12;Stress-activated protein kinase 1b;SAPK1b;Stress-activated protein kinase JNK3;c-Jun N-terminal kinase 3 -MK11_HUMAN Q15759 MAPK11 MAPK11 P38B p38_group 2.7.11.24 MAPK11;PRKM11;SAPK2;SAPK2B EC 2.7.11.24;Mitogen-activated protein kinase 11;MAP kinase 11;MAPK 11;Mitogen-activated protein kinase p38 beta;MAP kinase p38 beta;p38b;Stress-activated protein kinase 2b;SAPK2b;p38-2;Isoform 2 of Mitogen-activated protein kinase 11 -MK12_HUMAN P53778 MAPK12 MAPK12 P38G p38_group 2.7.11.24 MAPK12;ERK6;SAPK3 2.7.11.24;Mitogen-activated protein kinase 12;MAP kinase 12;MAPK 12;Extracellular signal-regulated kinase 6;ERK-6;Mitogen-activated protein kinase p38 gamma;MAP kinase p38 gamma;Stress-activated protein kinase 3;Isoform 2 of Mitogen-activated protein kinase 12 -MK13_HUMAN O15264 MAPK13 MAPK13 P38D p38_group 2.7.11.24 MAPK13;PRKM13;SAPK4 EC 2.7.11.24;Mitogen-activated protein kinase 13;MAP kinase 13;MAPK 13;Mitogen-activated protein kinase p38 delta;MAP kinase p38 delta;Stress-activated protein kinase 4;Isoform 2 of Mitogen-activated protein kinase 13 -MK14_HUMAN Q16539 MAPK14 MAPK14 P38A p38_group 2.7.11.24 MAPK14;CSBP;CSBP1;CSBP2;CSPB1;MXI2;SAPK2A 2.7.11.24;CSBP;Mitogen-activated protein kinase 14;MAP kinase 14;MAPK 14;Cytokine suppressive anti-inflammatory drug-binding protein;CSAID-binding protein;MAP kinase MXI2;MAX-interacting protein 2;Mitogen-activated protein kinase p38 alpha;MAP kinase p38 alpha;Stress-activated protein kinase 2a;SAPK2a;Isoform Exip of Mitogen-activated protein kinase 14 -MK15_HUMAN Q8TD08 ERK7 (PSP) ERK7 2.7.11.24 MAPK15;ERK7;ERK8 EC 2.7.11.24;Mitogen-activated protein kinase 15;MAP kinase 15;MAPK 15;Extracellular signal-regulated kinase 7;ERK-7;Extracellular signal-regulated kinase 8;ERK-8;Isoform 3 of Mitogen-activated protein kinase 15 -MKNK1_HUMAN Q9BUB5 Mnk1 Mnk1 Mnk1 iso2 2.7.11.1 MKNK1;MNK1 2.7.11.1;MAP kinase-interacting serine/threonine-protein kinase 1;MAP kinase signal-integrating kinase 1;MAPK signal-integrating kinase 1;Mnk1;Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 -MKNK2_HUMAN Q9HBH9 Mnk2 Mnk2 Mnk2 2.7.11.1 GPRK7;MKNK2;MNK2 EC 2.7.11.1;MAP kinase-interacting serine/threonine-protein kinase 2;MAP kinase signal-integrating kinase 2;MAPK signal-integrating kinase 2;Mnk2;Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 2 -MOK_HUMAN Q9UQ07 MOK (NetworKIN) MOK RCK_group 2.7.11.22 MOK;RAGE;RAGE1 2.7.11.22;MAPK/MAK/MRK overlapping kinase;MOK protein kinase;Renal tumor antigen 1;RAGE-1;Isoform 6 of MAPK/MAK/MRK overlapping kinase -MOS_HUMAN P00540 MOS MOS MOS 2.7.11.1 MOS EC 2.7.11.1;Proto-oncogene serine/threonine-protein kinase mos;Oocyte maturation factor mos;Proto-oncogene c-Mos -MP2K1_HUMAN Q02750 MAP2K1 MAP2K1 MEK1 MAP2K_group 2.7.12.2 MAP2K1;MEK1;PRKMK1 EC 2.7.12.2;Dual specificity mitogen-activated protein kinase kinase 1;MAP kinase kinase 1;MAPKK 1;MKK1;ERK activator kinase 1;MAPK/ERK kinase 1;MEK 1 -MP2K2_HUMAN P36507 MAP2K2 MAP2K2 MEK2 MAP2K_group 2.7.12.2 MAP2K2;MEK2;MKK2;PRKMK2 2.7.12.2;Dual specificity mitogen-activated protein kinase kinase 2;MAP kinase kinase 2;MAPKK 2;ERK activator kinase 2;MAPK/ERK kinase 2;MEK 2 -MP2K3_HUMAN P46734 MAP2K3 MAP2K3 MKK3 MAP2K_group 2.7.12.2 MAP2K3;MEK3;MKK3;PRKMK3;SKK2 Dual specificity mitogen-activated protein kinase kinase 3;MAP kinase kinase 3;MAPKK 3;2.7.12.2;MAPK/ERK kinase 3;MEK 3;Stress-activated protein kinase kinase 2;SAPK kinase 2;SAPKK-2;SAPKK2;Isoform 1 of Dual specificity mitogen-activated protein kinase kinase 3 -MP2K4_HUMAN P45985 MAP2K4 MAP2K4 MKK4 MAP2K_group 2.7.12.2 MAP2K4;JNKK1;MEK4;MKK4;PRKMK4;SEK1;SERK1;SKK1 EC 2.7.12.2;SEK1;Dual specificity mitogen-activated protein kinase kinase 4;MAP kinase kinase 4;MAPKK 4;JNK-activating kinase 1;MAPK/ERK kinase 4;MEK 4;SAPK/ERK kinase 1;Stress-activated protein kinase kinase 1;SAPK kinase 1;SAPKK-1;SAPKK1;c-Jun N-terminal kinase kinase 1;JNKK;Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 4 -MP2K5_HUMAN Q13163 MAP2K_group MAP2K5 MEK5 MAP2K_group 2.7.12.2 MAP2K5;MEK5;MKK5;PRKMK5 EC 2.7.12.2;Dual specificity mitogen-activated protein kinase kinase 5;MAP kinase kinase 5;MAPKK 5;MAPK/ERK kinase 5;MEK 5 -MP2K6_HUMAN P52564 MAP2K6 MAP2K6 MKK6 MAP2K_group 2.7.12.2 MAP2K6;MEK6;MKK6;PRKMK6;SKK3 Dual specificity mitogen-activated protein kinase kinase 6;MAP kinase kinase 6;MAPKK 6;EC 2.7.12.2;MAPK/ERK kinase 6;MEK 6;Stress-activated protein kinase kinase 3;SAPK kinase 3;SAPKK-3;SAPKK3;Isoform 2 of Dual specificity mitogen-activated protein kinase kinase 6 -MP2K7_HUMAN O14733 MAP2K7 MAP2K7 MKK7 MAP2K_group 2.7.12.2 MAP2K7;JNKK2;MEK7;MKK7;PRKMK7;SKK4 EC 2.7.12.2;Dual specificity mitogen-activated protein kinase kinase 7;MAP kinase kinase 7;MAPKK 7;JNK-activating kinase 2;MAPK/ERK kinase 7;MEK 7;Stress-activated protein kinase kinase 4;SAPK kinase 4;SAPKK-4;SAPKK4;c-Jun N-terminal kinase kinase 2;JNK kinase 2;JNKK 2;Isoform 4 of Dual specificity mitogen-activated protein kinase kinase 7 -MRCKA_HUMAN Q5VT25 MRCKa MRCKa MRCKA DMPK_group 2.7.11.1 CDC42BPA;KIAA0451 2.7.11.1;Myotonic dystrophy protein kinase-like alpha;Serine/threonine-protein kinase MRCK alpha;CDC42-binding protein kinase alpha;DMPK-like alpha;Myotonic dystrophy kinase-related CDC42-binding kinase alpha;MRCK alpha;Isoform 6 of Serine/threonine-protein kinase MRCK alpha -MRCKB_HUMAN Q9Y5S2 MRCKb (NetworKIN) MRCKb MRCKB DMPK_group 2.7.11.1 CDC42BPB;KIAA1124 EC 2.7.11.1;Serine/threonine-protein kinase MRCK beta;CDC42-binding protein kinase beta;CDC42BP-beta;DMPK-like beta;Myotonic dystrophy kinase-related CDC42-binding kinase beta;MRCK beta;Myotonic dystrophy protein kinase-like beta -MRCKG_HUMAN Q6DT37 DMPK_group DMPK2 DMPK_group 2.7.11.1 CDC42BPG;DMPK2 EC 2.7.11.1;Serine/threonine-protein kinase MRCK gamma;CDC42-binding protein kinase gamma;DMPK-like gamma;Myotonic dystrophy kinase-related CDC42-binding kinase gamma;MRCK gamma;MRCKG;Myotonic dystrophy protein kinase-like gamma;Myotonic dystrophy protein kinase-like alpha -MTOR_HUMAN P42345 mTOR mTOR mTOR 2.7.11.1 MTOR;FRAP;FRAP1;FRAP2;RAFT1;RAPT1 2.7.11.1;Serine/threonine-protein kinase mTOR;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP12-rapamycin complex-associated protein;Mammalian target of rapamycin;mTOR;Mechanistic target of rapamycin;Rapamycin and FKBP12 target 1;Rapamycin target protein 1 -MYLK2_HUMAN Q9H1R3 skMLCK (PSP) skMLCK 2.7.11.18 MYLK2 EC 2.7.11.18;Myosin light chain kinase 2, skeletal/cardiac muscle;MLCK2 -MYLK3_HUMAN Q32MK0 caMLCK (PSP) caMLCK 2.7.11.18 MLCK;MYLK3 Myosin light chain kinase 3;EC 2.7.11.18;Cardiac-MyBP-C-associated Ca/CaM kinase;Cardiac-MLCK -MYLK_HUMAN Q15746 smMLCK (PSP) smMLCK 2.7.11.18 MYLK;MLCK;MLCK1;MYLK1 MLCK;Myosin light chain kinase, smooth muscle;smMLCK;2.7.11.18;Kinase-related protein;KRP;Telokin;Myosin light chain kinase, smooth muscle, deglutamylated form;Isoform 6 of Myosin light chain kinase, smooth muscle -MYO3A_HUMAN Q8NEV4 MYO3A (PSP) MYO3A 2.7.11.1 MYO3A EC 2.7.11.1;Myosin-IIIa;Isoform 2 of Myosin-IIIa -NDKA_HUMAN P15531 NME1 (PSP) NME1 2.7.4.6 NME1;NDPKA;NM23 EC 2.7.4.6;Nucleoside diphosphate kinase A;NDK A;NDP kinase A;Granzyme A-activated DNase;GAAD;Metastasis inhibition factor nm23;NM23-H1;Tumor metastatic process-associated protein;Isoform 2 of Nucleoside diphosphate kinase A -NDKB_HUMAN P22392 NME2 (PSP) NME2 2.7.13.3;2.7.4.6 NME2;NM23B 2.7.4.6;Nucleoside diphosphate kinase B;NDK B;NDP kinase B;C-myc purine-binding transcription factor PUF;Histidine protein kinase NDKB;2.7.13.3;nm23-H2 -NEK11_HUMAN Q8NG66 NEK11 (NetworKIN) NEK11 NEK11 NEK1_NEK5_NEK3_NEK4_NEK11_NEK2_group 2.7.11.1 NEK11 2.7.11.1;Serine/threonine-protein kinase Nek11;Never in mitosis A-related kinase 11;NimA-related protein kinase 11;Isoform 4 of Serine/threonine-protein kinase Nek11 -NEK1_HUMAN Q96PY6 NEK1 (NetworKIN) NEK1 NEK1 NEK1_NEK5_NEK3_NEK4_NEK11_NEK2_group 2.7.11.1 NEK1;KIAA1901 2.7.11.1;Serine/threonine-protein kinase Nek1;Never in mitosis A-related kinase 1;NimA-related protein kinase 1;Renal carcinoma antigen NY-REN-55;Isoform 5 of Serine/threonine-protein kinase Nek1 -NEK2_HUMAN P51955 NEK2 NEK2 NEK2 NEK1_NEK5_NEK3_NEK4_NEK11_NEK2_group 2.7.11.1 NEK2;NEK2A;NLK1 EC 2.7.11.1;Serine/threonine-protein kinase Nek2;HSPK 21;Never in mitosis A-related kinase 2;NimA-related protein kinase 2;NimA-like protein kinase 1;Isoform 4 of Serine/threonine-protein kinase Nek2 -NEK3_HUMAN P51956 NEK3 (NetworKIN) NEK3 NEK3 NEK1_NEK5_NEK3_NEK4_NEK11_NEK2_group 2.7.11.1 NEK3 EC 2.7.11.1;Serine/threonine-protein kinase Nek3;HSPK 36;Never in mitosis A-related kinase 3;NimA-related protein kinase 3 -NEK4_HUMAN P51957 NEK4 (NetworKIN) NEK4 NEK1_NEK5_NEK3_NEK4_NEK11_NEK2_group 2.7.11.1 NEK4;STK2 2.7.11.1;Serine/threonine-protein kinase Nek4;Never in mitosis A-related kinase 4;NimA-related protein kinase 4;Serine/threonine-protein kinase 2;Serine/threonine-protein kinase NRK2;Isoform 2 of Serine/threonine-protein kinase Nek4 -NEK6_HUMAN Q9HC98 NEK6 NEK6 NEK6 2.7.11.1 NEK6 EC 2.7.11.1;Serine/threonine-protein kinase Nek6;Never in mitosis A-related kinase 6;NimA-related protein kinase 6;Protein kinase SID6-1512;Isoform 2 of Serine/threonine-protein kinase Nek6 -NEK7_HUMAN Q8TDX7 NEK7 (PSP) NEK7 2.7.11.1 NEK7 EC 2.7.11.1;Serine/threonine-protein kinase Nek7;Never in mitosis A-related kinase 7;NimA-related protein kinase 7;Isoform 2 of Serine/threonine-protein kinase Nek7 -NEK9_HUMAN Q8TD19 NEK9 NEK9 NEK9 2.7.11.1 NEK8;NEK9;KIAA1995;NERCC EC 2.7.11.1;Serine/threonine-protein kinase Nek9;Nercc1 kinase;Never in mitosis A-related kinase 9;NimA-related protein kinase 9;NimA-related kinase 8;Nek8 -NLK_HUMAN Q9UBE8 NLK NLK NLK MAPK3_MAPK1_MAPK7_NLK_group 2.7.11.24 NLK;LAK1 EC 2.7.11.24;Serine/threonine-protein kinase NLK;Nemo-like kinase;Protein LAK1 -NPM_HUMAN P06748 NPM-ALK (PSP) NPM-ALK NPM1;NPM NPM;Nucleophosmin;Nucleolar phosphoprotein B23;Nucleolar protein NO38;Numatrin -NRK_HUMAN Q7Z2Y5 NRK (NetworKIN) NRK MSN_group 2.7.11.1 NRK EC 2.7.11.1;Nik-related protein kinase -NTRK1_HUMAN P04629 TRKA TRKA TrkA Trk_group 2.7.10.1 NTRK1;MTC;TRK;TRKA 2.7.10.1;High affinity nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;Trk-A;gp140trk;p140-TrkA;Isoform TrkA-I of High affinity nerve growth factor receptor -NTRK2_HUMAN Q16620 TRKB TRKB TrkB Trk_group 2.7.10.1 NTRK2;TRKB 2.7.10.1;BDNF/NT-3 growth factors receptor;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B;Isoform TrkB-N-T1 of BDNF/NT-3 growth factors receptor -NTRK3_HUMAN Q16288 TRKC (NetworKIN) TRKC Trk_group 2.7.10.1 NTRK3;TRKC EC 2.7.10.1;NT-3 growth factor receptor;GP145-TrkC;Trk-C;Neurotrophic tyrosine kinase receptor type 3;TrkC tyrosine kinase;Isoform 5 of NT-3 growth factor receptor -NUAK1_HUMAN O60285 NuaK1 NuaK1 NuaK1 2.7.11.1 NUAK1;ARK5;KIAA0537;OMPHK1 EC 2.7.11.1;ARK5;NUAK family SNF1-like kinase 1;AMPK-related protein kinase 5;Omphalocele kinase 1;Isoform 2 of NUAK family SNF1-like kinase 1 -NUAK2_HUMAN Q9H093 NuaK2 (PSP) NuaK2 2.7.11.1 NUAK2;OMPHK2;SNARK EC 2.7.11.1;SNARK;NUAK family SNF1-like kinase 2;Omphalocele kinase 2;SNF1/AMP kinase-related kinase -OXSR1_HUMAN O95747 OSR1 (PSP) OSR1 2.7.11.1 OXSR1;KIAA1101;OSR1 EC 2.7.11.1;Serine/threonine-protein kinase OSR1;Oxidative stress-responsive 1 protein -P3C2A_HUMAN O00443 PIK3C2A (PSP) PIK3C2A 2.7.1.137;2.7.1.153;2.7.1.154 PIK3C2A 2.7.1.137;2.7.1.153;2.7.1.154;Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha;PI3K-C2-alpha;PtdIns-3-kinase C2 subunit alpha;Phosphoinositide 3-kinase-C2-alpha -P85A_HUMAN P27986 PIK3R1 (PSP) PIK3R1 PIK3R1;GRB1 Phosphatidylinositol 3-kinase regulatory subunit alpha;PI3-kinase regulatory subunit alpha;PI3K regulatory subunit alpha;PtdIns-3-kinase regulatory subunit alpha;Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;PI3-kinase subunit p85-alpha;PtdIns-3-kinase regulatory subunit p85-alpha -PAK1_HUMAN Q13153 PAK1 PAK1 PAK1 PAK_group 2.7.11.1 PAK1 2.7.11.1;Serine/threonine-protein kinase PAK 1;Alpha-PAK;p21-activated kinase 1;PAK-1;p65-PAK -PAK2_HUMAN Q13177 PAK2 PAK2 PAK2 PAK_group 2.7.11.1 PAK2 EC 2.7.11.1;p58;Serine/threonine-protein kinase PAK 2;Gamma-PAK;PAK65;S6/H4 kinase;p21-activated kinase 2;PAK-2;PAK-2p27;p27;PAK-2p34;p34;C-t-PAK2 -PAK3_HUMAN O75914 PAK3 PAK3 PAK_group 2.7.11.1 PAK3;OPHN3 EC 2.7.11.1;Serine/threonine-protein kinase PAK 3;Beta-PAK;Oligophrenin-3;p21-activated kinase 3;PAK-3 -PAK4_HUMAN O96013 PAK4 (NetworKIN) PAK4 PAK4 PAK_group 2.7.11.1 PAK4;KIAA1142 EC 2.7.11.1;Serine/threonine-protein kinase PAK 4;p21-activated kinase 4;PAK-4;Isoform 3 of Serine/threonine-protein kinase PAK 4 -PAK5_HUMAN Q9P286 PAK5 PAK5 PAK5 PAK_group 2.7.11.1 PAK5;KIAA1264;PAK7 EC 2.7.11.1;PAK-5;Serine/threonine-protein kinase PAK 5;p21-activated kinase 5;p21-activated kinase 7;PAK-7 -PAK6_HUMAN Q9NQU5 PAK5 PAK5 PAK6 PAK_group 2.7.11.1 PAK6;PAK5 EC 2.7.11.1;Serine/threonine-protein kinase PAK 6;PAK-5;p21-activated kinase 6;PAK-6;Isoform 2 of Serine/threonine-protein kinase PAK 6 -PAK6_HUMAN Q9NQU5 PAK_group PAK6 PAK6 PAK_group 2.7.11.1 PAK6;PAK5 EC 2.7.11.1;Serine/threonine-protein kinase PAK 6;PAK-5;p21-activated kinase 6;PAK-6;Isoform 2 of Serine/threonine-protein kinase PAK 6 -PASK_HUMAN Q96RG2 PASK PASK PASK 2.7.11.1 PASK;KIAA0135 EC 2.7.11.1;PAS domain-containing serine/threonine-protein kinase;PAS-kinase;PASKIN;hPASK -PCKGC_HUMAN P35558 PCK1 (PSP) PCK1 4.1.1.32 PCK1;PEPCK1 2.7.11.-;Phosphoenolpyruvate carboxykinase, cytosolic [GTP];PEPCK-C;4.1.1.32;Serine-protein kinase PCK1;Isoform 2 of Phosphoenolpyruvate carboxykinase, cytosolic [GTP] -PDK1_HUMAN Q15118 PDHK1 PDHK1 PDHK1 PDHK_group 2.7.11.2 PDK1;PDHK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial;EC 2.7.11.2;Pyruvate dehydrogenase kinase isoform 1;PDH kinase 1 -PDK2_HUMAN Q15119 PDHK2 PDHK2 PDHK2 PDHK_group 2.7.11.2 PDK2;PDHK2 EC 2.7.11.2;[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial;Pyruvate dehydrogenase kinase isoform 2;PDH kinase 2;PDKII -PDK2_HUMAN Q15119 PDK-2 PDK-2 PDHK2 2.7.11.2 PDK2;PDHK2 EC 2.7.11.2;[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial;Pyruvate dehydrogenase kinase isoform 2;PDH kinase 2;PDKII -PDK3_HUMAN Q15120 PDHK3 PDHK3 PDHK3 PDHK_group 2.7.11.2 PDK3;PDHK3 EC 2.7.11.2;[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial;Pyruvate dehydrogenase kinase isoform 3 -PDK4_HUMAN Q16654 PDHK4 PDHK4 PDHK4 PDHK_group 2.7.11.2 PDK4;PDHK4 EC 2.7.11.2;[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial;Pyruvate dehydrogenase kinase isoform 4 -PDPK1_HUMAN O15530 PDK-1 PDK-1 PDK1 2.7.11.1 PDK1;PDPK1 EC 2.7.11.1;3-phosphoinositide-dependent protein kinase 1;hPDK1;Isoform 4 of 3-phosphoinositide-dependent protein kinase 1 -PGFRA_HUMAN P16234 PDGFR_alpha PDGFRalpha PDGFRA FLT3_CSF1R_Kit_PDGFR_group 2.7.10.1 PDGFRA;PDGFR2;RHEPDGFRA EC 2.7.10.1;Platelet-derived growth factor receptor alpha;PDGF-R-alpha;PDGFR-alpha;Alpha platelet-derived growth factor receptor;Alpha-type platelet-derived growth factor receptor;CD140 antigen-like family member A;CD140a antigen;Platelet-derived growth factor alpha receptor;Platelet-derived growth factor receptor 2;PDGFR-2;CD140a -PGFRB_HUMAN P09619 PDGFR_beta PDGFRbeta PDGFRB FLT3_CSF1R_Kit_PDGFR_group 2.7.10.1 PDGFRB;PDGFR;PDGFR1 EC 2.7.10.1;Platelet-derived growth factor receptor beta;PDGF-R-beta;PDGFR-beta;Beta platelet-derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1;PDGFR-1;CD140b;Isoform 2 of Platelet-derived growth factor receptor beta -PGK1_HUMAN P00558 PGK1 (PSP) PGK1 2.7.2.3 PGK1;PGKA;MIG10;OK/SW-cl.110 Phosphoglycerate kinase 1;2.7.2.3;Cell migration-inducing gene 10 protein;Primer recognition protein 2;PRP 2 -PIM1_HUMAN P11309 PIM-1 PIM-1 Pim1 2.7.11.1 PIM1 EC 2.7.11.1;Serine/threonine-protein kinase pim-1;Isoform 2 of Serine/threonine-protein kinase pim-1 -PIM1_HUMAN P11309 Pim1 (NetworKIN) Pim1 Pim1 Pim3_Pim1_group 2.7.11.1 PIM1 EC 2.7.11.1;Serine/threonine-protein kinase pim-1;Isoform 2 of Serine/threonine-protein kinase pim-1 -PIM2_HUMAN Q9P1W9 Pim2 (NetworKIN) Pim2 Pim2 Pim2 2.7.11.1 PIM2 EC 2.7.11.1;Serine/threonine-protein kinase pim-2;Pim-2h -PIM3_HUMAN Q86V86 Pim3 (NetworKIN) Pim3 Pim3 Pim3_Pim1_group 2.7.11.1 PIM3 EC 2.7.11.1;Serine/threonine-protein kinase pim-3 -PINK1_HUMAN Q9BXM7 PINK1 (PSP) PINK1 2.7.11.1 PINK1 2.7.11.1;Serine/threonine-protein kinase PINK1, mitochondrial;BRPK;PTEN-induced putative kinase protein 1;Isoform 2 of Serine/threonine-protein kinase PINK1, mitochondrial -PK3CA_HUMAN P42336 PIK3CA PIK3CA PIK3CA 2.7.1.137;2.7.1.153;2.7.11.1 PIK3CA 2.7.11.1;2.7.1.137;2.7.1.153;Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform;PI3-kinase subunit alpha;PI3K-alpha;PI3Kalpha;PtdIns-3-kinase subunit alpha;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha;PtdIns-3-kinase subunit p110-alpha;p110alpha;Phosphoinositide 3-kinase alpha;Phosphoinositide-3-kinase catalytic alpha polypeptide;Serine/threonine protein kinase PIK3CA -PK3CB_HUMAN P42338 PIK3CB PIK3CB PIK3CB 2.7.1.153;2.7.11.1 PIK3CB;PIK3C1 2.7.11.1;2.7.1.153;Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform;PI3-kinase subunit beta;PI3K-beta;PI3Kbeta;PtdIns-3-kinase subunit beta;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;PtdIns-3-kinase subunit p110-beta;p110beta;Serine/threonine protein kinase PIK3CB -PK3CD_HUMAN O00329 PIK3CD PIK3CD PIK3CD 2.7.1.137;2.7.1.153 PIK3CD Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform;PI3-kinase subunit delta;PI3K-delta;PI3Kdelta;PtdIns-3-kinase subunit delta;2.7.1.137;2.7.1.153;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta;PtdIns-3-kinase subunit p110-delta;p110delta -PK3CG_HUMAN P48736 PIK3CG PIK3CG PIK3CG 2.7.1.137;2.7.1.153;2.7.1.154;2.7.11.1 PIK3CG 2.7.11.1;2.7.1.137;2.7.1.153;2.7.1.154;Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform;PI3-kinase subunit gamma;PI3K-gamma;PI3Kgamma;PtdIns-3-kinase subunit gamma;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma;PtdIns-3-kinase subunit p110-gamma;p110gamma;Phosphoinositide-3-kinase catalytic gamma polypeptide;Serine/threonine protein kinase PIK3CG;p120-PI3K -PKN1_HUMAN Q16512 PAK1 PAK1 PKN1 PAK_group 2.7.11.13 PKN1;PAK1;PKN;PRK1;PRKCL1 2.7.11.13;PAK-1;Serine/threonine-protein kinase N1;Protease-activated kinase 1;Protein kinase C-like 1;Protein kinase C-like PKN;Protein kinase PKN-alpha;Protein-kinase C-related kinase 1;Serine-threonine protein kinase N;Isoform 3 of Serine/threonine-protein kinase N1 -PKN1_HUMAN Q16512 PKN1 PKN1 PKN1 2.7.11.13 PKN1;PAK1;PKN;PRK1;PRKCL1 2.7.11.13;PAK-1;Serine/threonine-protein kinase N1;Protease-activated kinase 1;Protein kinase C-like 1;Protein kinase C-like PKN;Protein kinase PKN-alpha;Protein-kinase C-related kinase 1;Serine-threonine protein kinase N;Isoform 3 of Serine/threonine-protein kinase N1 -PKN2_HUMAN Q16513 PKN2 (PSP) PKN2 2.7.11.13 PKN2;PRK2;PRKCL2 EC 2.7.11.13;Serine/threonine-protein kinase N2;PKN gamma;Protein kinase C-like 2;Protein-kinase C-related kinase 2;Isoform 3 of Serine/threonine-protein kinase N2 -PKN3_HUMAN Q6P5Z2 PKN3 (PSP) PKN3 2.7.11.13 PKN3;PKNBETA EC 2.7.11.13;Serine/threonine-protein kinase N3;Protein kinase PKN-beta;Protein-kinase C-related kinase 3 -PLK1_HUMAN P53350 PLK1 PLK1 PLK1 PLK_group 2.7.11.21 PLK1;PLK 2.7.11.21;Serine/threonine-protein kinase 13;Serine/threonine-protein kinase PLK1;Polo-like kinase 1;PLK-1;STPK13 -PLK2_HUMAN Q9NYY3 PLK2 (NetworKIN) PLK2 PLK2 PLK_group 2.7.11.21 PLK2;SNK Serine/threonine-protein kinase PLK2;EC 2.7.11.21;Polo-like kinase 2;PLK-2;hPlk2;Serine/threonine-protein kinase SNK;hSNK;Serum-inducible kinase -PLK3_HUMAN Q9H4B4 PLK3 PLK3 PLK3 2.7.11.21 PLK3;CNK;FNK;PRK EC 2.7.11.21;Serine/threonine-protein kinase PLK3;Cytokine-inducible serine/threonine-protein kinase;FGF-inducible kinase;Polo-like kinase 3;PLK-3;Proliferation-related kinase -PLK4_HUMAN O00444 PLK4 (NetworKIN) PLK4 PLK4 PLK_group 2.7.11.21 PLK4;SAK;STK18 Serine/threonine-protein kinase PLK4;2.7.11.21;Polo-like kinase 4;PLK-4;Serine/threonine-protein kinase 18;Serine/threonine-protein kinase Sak;Isoform 2 of Serine/threonine-protein kinase PLK4 -PMYT1_HUMAN Q99640 Myt1 (PSP) Myt1 2.7.11.1 MYT1;PKMYT1 EC 2.7.11.1;Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase;Myt1 kinase;Isoform 4 of Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase -PRKDC_HUMAN P78527 DNA-PK DNAPK DNAPK DNAPK 2.7.11.1 PRKDC;HYRC;HYRC1 2.7.11.1;DNA-dependent protein kinase catalytic subunit;DNA-PK catalytic subunit;DNA-PKcs;DNPK1;p460 -PRKX_HUMAN P51817 PRKX (PSP) PRKX 2.7.11.1 PRKX;PKX1 EC 2.7.11.1;cAMP-dependent protein kinase catalytic subunit PRKX;PrKX;Protein kinase X;Protein kinase X-linked;Serine/threonine-protein kinase PRKX;Protein kinase PKX1 -PRP4B_HUMAN Q13523 PRP4 PRP4 PRP4 2.7.11.1 PRP4;PRPF4B;KIAA0536;PRP4H;PRP4K EC 2.7.11.1;Serine/threonine-protein kinase PRP4 homolog;PRP4 kinase;PRP4 pre-mRNA-processing factor 4 homolog -PRPK_HUMAN Q96S44 PRPK (PSP) PRPK 2.7.11.1 TP53RK;C20orf64;PRPK 3.6.-.-;2.7.11.1;EKC/KEOPS complex subunit TP53RK;Atypical serine/threonine protein kinase TP53RK;Nori-2;TP53-regulating kinase;p53-related protein kinase -PTK6_HUMAN Q13882 Brk Brk Brk Brk 2.7.10.2 PTK6;BRK 2.7.10.2;Protein-tyrosine kinase 6;Breast tumor kinase;Tyrosine-protein kinase BRK -PTK6_HUMAN Q13882 Brk Brk Brk Src_group 2.7.10.2 PTK6;BRK 2.7.10.2;Protein-tyrosine kinase 6;Breast tumor kinase;Tyrosine-protein kinase BRK -Q15300_HUMAN Q15300 Ret iso3 (PSP) Ret iso3 RET/PTC2 RET tyrosine kinase/cAMP protein kinase A subunit RI -RAF1_HUMAN P04049 RAF1 RAF1 RAF1 ARAF_BRAF_RAF1_group 2.7.11.1 RAF1;RAF 2.7.11.1;RAF proto-oncogene serine/threonine-protein kinase;Proto-oncogene c-RAF;cRaf;Raf-1 -RET_HUMAN P07949 RET RET Ret 2.7.10.1 PTC;RET;CDHF12;CDHR16;RET51 EC 2.7.10.1;Proto-oncogene tyrosine-protein kinase receptor Ret;Cadherin family member 12;Proto-oncogene c-Ret;Soluble RET kinase fragment;Extracellular cell-membrane anchored RET cadherin 120 kDa fragment -RIOK3_HUMAN O14730 RIOK3 (PSP) RIOK3 2.7.11.1 RIOK3;SUDD EC 2.7.11.1;Serine/threonine-protein kinase RIO3;RIO kinase 3;sudD homolog -RIPK1_HUMAN Q13546 RIPK1 (PSP) RIPK1 2.7.11.1 RIPK1;RIP;RIP1 2.7.11.1;Receptor-interacting serine/threonine-protein kinase 1;Cell death protein RIP;Receptor-interacting protein 1;RIP-1 -RIPK2_HUMAN O43353 RIPK2 (PSP) RIPK2 2.7.10.2;2.7.11.1 RIPK2;CARDIAK;UNQ277/PRO314/PRO34092 EC 2.7.11.1;EC 2.7.10.2;Receptor-interacting serine/threonine-protein kinase 2;CARD-containing interleukin-1 beta-converting enzyme-associated kinase;CARD-containing IL-1 beta ICE-kinase;RIP-like-interacting CLARP kinase;Receptor-interacting protein 2;RIP-2;Tyrosine-protein kinase RIPK2 -RIPK3_HUMAN Q9Y572 RIPK3 (PSP) RIPK3 2.7.11.1 RIPK3;RIP3 2.7.11.1;Receptor-interacting serine/threonine-protein kinase 3;RIP-like protein kinase 3;Receptor-interacting protein 3;RIP-3 -ROCK1_HUMAN Q13464 ROCK1 ROCK1 ROCK1 ROCK_group 2.7.11.1 ROCK1 2.7.11.1;Rho-associated protein kinase 1;Renal carcinoma antigen NY-REN-35;Rho-associated, coiled-coil-containing protein kinase 1;Rho-associated, coiled-coil-containing protein kinase I;ROCK-I;p160 ROCK-1;p160ROCK -ROCK2_HUMAN O75116 ROCK2 ROCK2 ROCK2 ROCK_group 2.7.11.1 ROCK2;KIAA0619 EC 2.7.11.1;Rho-associated protein kinase 2;Rho kinase 2;Rho-associated, coiled-coil-containing protein kinase 2;Rho-associated, coiled-coil-containing protein kinase II;ROCK-II;p164 ROCK-2 -RON_HUMAN Q04912 RON RON Ron 2.7.10.1 MST1R;PTK8;RON EC 2.7.10.1;Macrophage-stimulating protein receptor;MSP receptor;CDw136;Protein-tyrosine kinase 8;p185-Ron;CD136;Macrophage-stimulating protein receptor alpha chain;Macrophage-stimulating protein receptor beta chain;Isoform RON-5 of Macrophage-stimulating protein receptor -RON_HUMAN Q04912 Ron (NetworKIN) Ron Ron Met_group 2.7.10.1 MST1R;PTK8;RON EC 2.7.10.1;Macrophage-stimulating protein receptor;MSP receptor;CDw136;Protein-tyrosine kinase 8;p185-Ron;CD136;Macrophage-stimulating protein receptor alpha chain;Macrophage-stimulating protein receptor beta chain;Isoform RON-5 of Macrophage-stimulating protein receptor -SGK1_HUMAN O00141 SGK1 (NetworKIN) SGK1 SGK1 SGK_group 2.7.11.1 SGK1;SGK EC 2.7.11.1;Serine/threonine-protein kinase Sgk1;Serum/glucocorticoid-regulated kinase 1;Isoform 2 of Serine/threonine-protein kinase Sgk1 -SGK2_HUMAN Q9HBY8 SGK2 (NetworKIN) SGK2 SGK_group 2.7.11.1 SGK2 EC 2.7.11.1;Serine/threonine-protein kinase Sgk2;Serum/glucocorticoid-regulated kinase 2;Isoform 2 of Serine/threonine-protein kinase Sgk2 -SGK3_HUMAN Q96BR1 SGK3 (NetworKIN) SGK3 SGK3 SGK_group 2.7.11.1 SGK3;CISK;SGKL EC 2.7.11.1;Serine/threonine-protein kinase Sgk3;Cytokine-independent survival kinase;Serum/glucocorticoid-regulated kinase 3;Serum/glucocorticoid-regulated kinase-like;Isoform 2 of Serine/threonine-protein kinase Sgk3 -SIK1_HUMAN P57059 SIK SIK SIK 2.7.11.1 SIK1;SIK;SNF1LK 2.7.11.1;Serine/threonine-protein kinase SIK1;Salt-inducible kinase 1;SIK-1;Serine/threonine-protein kinase SNF1-like kinase 1;Serine/threonine-protein kinase SNF1LK -SIK2_HUMAN Q9H0K1 QIK (PSP) QIK 2.7.11.1 SIK2;KIAA0781;QIK;SNF1LK2 2.7.11.1;Serine/threonine-protein kinase SIK2;Qin-induced kinase;Salt-inducible kinase 2;SIK-2;Serine/threonine-protein kinase SNF1-like kinase 2 -SLK_HUMAN Q9H2G2 SLK (NetworKIN) SLK SLK SLK_group 2.7.11.1 STK2;SLK;KIAA0204 EC 2.7.11.1;Serine/threonine-protein kinase 2;STE20-like serine/threonine-protein kinase;STE20-like kinase;hSLK;CTCL tumor antigen se20-9;STE20-related serine/threonine-protein kinase;STE20-related kinase;Isoform 2 of STE20-like serine/threonine-protein kinase -SMG1_HUMAN Q96Q15 SMG1 (PSP) SMG1 2.7.11.1 SMG1;ATX;KIAA0421;LIP EC 2.7.11.1;Serine/threonine-protein kinase SMG1;SMG-1;hSMG-1;Lambda/iota protein kinase C-interacting protein;Lambda-interacting protein;Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1 -SPEE_HUMAN P19623 Srm (NetworKIN) Srm Srm 2.5.1.16 SPS1;SRM;SRML1 Spermidine synthase;SPDSY;EC 2.5.1.16;Putrescine aminopropyltransferase -SPEE_HUMAN P19623 Srm (NetworKIN) Srm Src_group 2.5.1.16 SPS1;SRM;SRML1 Spermidine synthase;SPDSY;EC 2.5.1.16;Putrescine aminopropyltransferase -SRC_HUMAN P12931 SRC SRC Src 2.7.10.2 SRC;SRC1 2.7.10.2;Proto-oncogene tyrosine-protein kinase Src;Proto-oncogene c-Src;pp60c-src;p60-Src;Isoform 2 of Proto-oncogene tyrosine-protein kinase Src -SRC_HUMAN P12931 Src (NetworKIN) Src Src Src_group 2.7.10.2 SRC;SRC1 2.7.10.2;Proto-oncogene tyrosine-protein kinase Src;Proto-oncogene c-Src;pp60c-src;p60-Src;Isoform 2 of Proto-oncogene tyrosine-protein kinase Src -SRMS_HUMAN Q9H3Y6 SRMS (PSP) SRMS 2.7.10.2 SRMS;C20orf148 2.7.10.2;Tyrosine-protein kinase Srms -SRPK1_HUMAN Q96SB4 SRPK1 (PSP) SRPK1 2.7.11.1 SRPK1 EC 2.7.11.1;SRSF protein kinase 1;SFRS protein kinase 1;Serine/arginine-rich protein-specific kinase 1;SR-protein-specific kinase 1;Isoform 3 of SRSF protein kinase 1 -SRPK2_HUMAN P78362 SRPK2 (PSP) SRPK2 2.7.11.1 SRPK2 2.7.11.1;SRSF protein kinase 2;SFRS protein kinase 2;Serine/arginine-rich protein-specific kinase 2;SR-protein-specific kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal;Isoform 2 of SRSF protein kinase 2 -ST17A_HUMAN Q9UEE5 DRAK1 (PSP) DRAK1 2.7.11.1 STK17A;DRAK1 EC 2.7.11.1;Serine/threonine-protein kinase 17A;DAP kinase-related apoptosis-inducing protein kinase 1 -ST38L_HUMAN Q9Y2H1 NDR2 NDR2 NDR2 2.7.11.1 STK38L;KIAA0965;NDR2 EC 2.7.11.1;Serine/threonine-protein kinase 38-like;NDR2 protein kinase;Nuclear Dbf2-related kinase 2 -STK10_HUMAN O94804 LOK LOK LOK SLK_group 2.7.11.1 STK10;LOK EC 2.7.11.1;Serine/threonine-protein kinase 10;Lymphocyte-oriented kinase -STK11_HUMAN Q15831 LKB1 LKB1 LKB1 LKB1 2.7.11.1 STK11;LKB1;PJS 2.7.11.1;LKB1;Serine/threonine-protein kinase STK11;Liver kinase B1;hLKB1;Renal carcinoma antigen NY-REN-19 -STK16_HUMAN O75716 MPSK1 (PSP) MPSK1 2.7.10.2;2.7.11.1 STK16;MPSK1;PKL12;TSF1 EC 2.7.11.1;EC 2.7.10.2;Serine/threonine-protein kinase 16;Myristoylated and palmitoylated serine/threonine-protein kinase;MPSK;Protein kinase PKL12;TGF-beta-stimulated factor 1;TSF-1;Tyrosine-protein kinase STK16;hPSK -STK19_HUMAN P49842 G11 (PSP) G11 2.7.11.1 STK19;G11;RP1 2.7.11.1;Serine/threonine-protein kinase 19;Protein G11;Protein RP1;Isoform 4 of Serine/threonine-protein kinase 19 -STK24_HUMAN Q9Y6E0 MST3 MST3 MST3 YSK_group 2.7.11.1 STK3;STK24;MST3 EC 2.7.11.1;Serine/threonine-protein kinase 24;Mammalian STE20-like protein kinase 3;MST-3;STE20-like kinase MST3;Serine/threonine-protein kinase 24 36 kDa subunit;Mammalian STE20-like protein kinase 3 N-terminal;MST3/N;Serine/threonine-protein kinase 24 12 kDa subunit;Mammalian STE20-like protein kinase 3 C-terminal;MST3/C;Isoform A of Serine/threonine-protein kinase 24 -STK25_HUMAN O00506 YSK1 (NetworKIN) YSK1 YSK1 YSK_group 2.7.11.1 STK25;SOK1;YSK1 EC 2.7.11.1;Serine/threonine-protein kinase 25;Ste20-like kinase;Sterile 20/oxidant stress-response kinase 1;SOK-1;Ste20/oxidant stress response kinase 1;Isoform 2 of Serine/threonine-protein kinase 25 -STK26_HUMAN Q9P289 MST4 (NetworKIN) MST4 MST4 YSK_group 2.7.11.1 STK26;MASK;MST4 2.7.11.1;Serine/threonine-protein kinase 26;MST3 and SOK1-related kinase;Mammalian STE20-like protein kinase 4;MST-4;STE20-like kinase MST4;Serine/threonine-protein kinase MASK -STK33_HUMAN Q9BYT3 STK33 (PSP) STK33 2.7.11.1 STK33 EC 2.7.11.1;Serine/threonine-protein kinase 33 -STK38_HUMAN Q15208 NDR1 NDR1 NDR1 2.7.11.1 STK38;NDR1 EC 2.7.11.1;Serine/threonine-protein kinase 38;NDR1 protein kinase;Nuclear Dbf2-related kinase 1 -STK39_HUMAN Q9UEW8 STLK3 STLK3 STLK3 2.7.11.1 STK39;SPAK EC 2.7.11.1;STE20/SPS1-related proline-alanine-rich protein kinase;Ste-20-related kinase;DCHT;Serine/threonine-protein kinase 39 -STK3_HUMAN Q13188 MST2 (NetworKIN) MST2 MST2 MST_group 2.7.11.1 STK3;KRS1;MST2 EC 2.7.11.1;Serine/threonine-protein kinase 3;Mammalian STE20-like protein kinase 2;MST-2;STE20-like kinase MST2;Serine/threonine-protein kinase Krs-1;Serine/threonine-protein kinase 3 36kDa subunit;MST2/N;Serine/threonine-protein kinase 3 20kDa subunit;MST2/C;Isoform 2 of Serine/threonine-protein kinase 3 -STK4_HUMAN Q13043 MST1 MST1 MST1 MST_group 2.7.11.1 STK4;KRS2;MST1 EC 2.7.11.1;Serine/threonine-protein kinase 4;Mammalian STE20-like protein kinase 1;MST-1;STE20-like kinase MST1;Serine/threonine-protein kinase Krs-2;Serine/threonine-protein kinase 4 37kDa subunit;MST1/N;Serine/threonine-protein kinase 4 18kDa subunit;MST1/C;Isoform 2 of Serine/threonine-protein kinase 4 -STYK1_HUMAN Q6J9G0 STYK1 (PSP) STYK1 2.7.10.2 STYK1;NOK EC 2.7.10.2;Tyrosine-protein kinase STYK1;Novel oncogene with kinase domain;Protein PK-unique;Serine/threonine/tyrosine kinase 1 -T2FA_HUMAN P35269 GTF2F1 (PSP) GTF2F1 GTF2F1;RAP74 General transcription factor IIF subunit 1;General transcription factor IIF 74 kDa subunit;Transcription initiation factor IIF subunit alpha;TFIIF-alpha;Transcription initiation factor RAP74 -TAF1_HUMAN P21675 TAF1 (PSP) TAF1 2.3.1.48;2.7.11.1 TAF2A;TAF1;BA2R;CCG1;CCGS 2.3.1.48;EC 2.7.11.1;p250;Transcription initiation factor TFIID subunit 1;Cell cycle gene 1 protein;TBP-associated factor 250 kDa;Transcription initiation factor TFIID 250 kDa subunit;TAF(II)250;TAFII-250;TAFII250;Isoform 2 of Transcription initiation factor TFIID subunit 1 -TAOK1_HUMAN Q7L7X3 TAO1 (PSP) TAO1 2.7.11.1 TAOK1;KIAA1361;MAP3K16;MARKK EC 2.7.11.1;TAOK1;MARKK;Serine/threonine-protein kinase TAO1;Kinase from chicken homolog B;hKFC-B;MARK Kinase;Prostate-derived sterile 20-like kinase 2;PSK-2;PSK2;Prostate-derived STE20-like kinase 2;Thousand and one amino acid protein kinase 1;hTAOK1;Isoform 2 of Serine/threonine-protein kinase TAO1 -TAOK2_HUMAN Q9UL54 TAO2 (PSP) TAO2 2.7.11.1 TAOK2;KIAA0881;UNQ2971/PRO7431 EC 2.7.11.1;Serine/threonine-protein kinase TAO2;Kinase from chicken homolog C;hKFC-C;Prostate-derived sterile 20-like kinase 1;PSK-1;PSK1;Prostate-derived STE20-like kinase 1;Thousand and one amino acid protein kinase 2;Isoform 2 of Serine/threonine-protein kinase TAO2 -TBK1_HUMAN Q9UHD2 TBK1 TBK1 TBK1 2.7.11.1 TBK1;NAK 2.7.11.1;Serine/threonine-protein kinase TBK1;NF-kappa-B-activating kinase;T2K;TANK-binding kinase 1 -TEC_HUMAN P42680 TEC TEC TEC 2.7.10.2 TEC;PSCTK4 EC 2.7.10.2;Tyrosine-protein kinase Tec -TEC_HUMAN P42680 Tec (NetworKIN) Tec TEC Tec_group 2.7.10.2 TEC;PSCTK4 EC 2.7.10.2;Tyrosine-protein kinase Tec -TESK1_HUMAN Q15569 TESK1 TESK1 TESK1 2.7.12.1 TESK1 EC 2.7.12.1;Dual specificity testis-specific protein kinase 1;Testicular protein kinase 1 -TESK2_HUMAN Q96S53 TESK2 TESK2 2.7.12.1 TESK2 EC 2.7.12.1;Dual specificity testis-specific protein kinase 2;Testicular protein kinase 2;Isoform 3 of Dual specificity testis-specific protein kinase 2 -TGFR1_HUMAN P36897 TGFbR1 TGFbR1 TGFBR1 2.7.11.30 TGFBR1;ALK5;SKR4 EC 2.7.11.30;ALK5;SKR4;TGF-beta receptor type-1;TGFR-1;Activin A receptor type II-like protein kinase of 53kD;Activin receptor-like kinase 5;ALK-5;Serine/threonine-protein kinase receptor R4;TGF-beta type I receptor;Transforming growth factor-beta receptor type I;TGF-beta receptor type I;TbetaR-I;Isoform 2 of TGF-beta receptor type-1 -TGFR2_HUMAN P37173 TGFbR2 TGFbR2 TGFBR2 ACTR2_ACTR2B_TGFbR2_group 2.7.11.30 TGFBR2 EC 2.7.11.30;TGF-beta receptor type-2;TGFR-2;TGF-beta type II receptor;Transforming growth factor-beta receptor type II;TGF-beta receptor type II;TbetaR-II -TGM2_HUMAN P21980 TGM2 (PSP) TGM2 2.3.2.13;3.5.1.44 TGM2 2.3.1.-;3.4.-.-;Protein-glutamine gamma-glutamyltransferase 2;2.3.2.13;Erythrocyte transglutaminase;Heart G alpha(h);hhG alpha(h);Isopeptidase TGM2;Protein G alpha(h);G(h);Protein-glutamine deamidase TGM2;3.5.1.44;Protein-glutamine dopaminyltransferase TGM2;Protein-glutamine histaminyltransferase TGM2;Protein-glutamine noradrenalinyltransferase TGM2;Protein-glutamine serotonyltransferase TGM2;Tissue transglutaminase;tTG;tTgase;Transglutaminase C;TG(C);TGC;TGase C;Transglutaminase H;TGase H;Transglutaminase II;TGase II;Transglutaminase-2;TG2;TGase-2;hTG2;Isoform 3 of Protein-glutamine gamma-glutamyltransferase 2 -TIE1_HUMAN P35590 TIE1 TIE1 2.7.10.1 TIE1;TIE EC 2.7.10.1;Tyrosine-protein kinase receptor Tie-1;Isoform 2 of Tyrosine-protein kinase receptor Tie-1 -TIE2_HUMAN Q02763 TIE2 TIE2 TIE2 2.7.10.1 TEK;TIE2;VMCM;VMCM1 EC 2.7.10.1;Angiopoietin-1 receptor;Endothelial tyrosine kinase;Tunica interna endothelial cell kinase;Tyrosine kinase with Ig and EGF homology domains-2;Tyrosine-protein kinase receptor TEK;Tyrosine-protein kinase receptor TIE-2;hTIE2;p140 TEK;CD202b;Isoform 3 of Angiopoietin-1 receptor -TITIN_HUMAN Q8WZ42 Titin kinase Titin kinase 2.7.11.1 TTN EC 2.7.11.1;Titin;Connectin;Rhabdomyosarcoma antigen MU-RMS-40.14;Isoform 2 of Titin -TLK1_HUMAN Q9UKI8 TLK1 TLK1 TLK1 TLK_group 2.7.11.1 TLK1;KIAA0137 EC 2.7.11.1;Serine/threonine-protein kinase tousled-like 1;PKU-beta;Tousled-like kinase 1;Isoform 4 of Serine/threonine-protein kinase tousled-like 1 -TLK2_HUMAN Q86UE8 TLK2 (NetworKIN) TLK2 TLK2 TLK_group 2.7.11.1 TLK2 EC 2.7.11.1;Serine/threonine-protein kinase tousled-like 2;HsHPK;PKU-alpha;Tousled-like kinase 2 -TNIK_HUMAN Q9UKE5 TNIK (NetworKIN) TNIK TNIK MSN_group 2.7.11.1 TNIK;KIAA0551 EC 2.7.11.1;TRAF2 and NCK-interacting protein kinase -TOPK_HUMAN Q96KB5 PBK (PSP) PBK 2.7.12.2 PBK;TOPK EC 2.7.12.2;Lymphokine-activated killer T-cell-originated protein kinase;Cancer/testis antigen 84;CT84;MAPKK-like protein kinase;Nori-3;PDZ-binding kinase;Spermatogenesis-related protein kinase;SPK;T-LAK cell-originated protein kinase -TRPM6_HUMAN Q9BX84 Chak2 (NetworKIN) Chak2 ChaK2 Chak1_Chak2_group 2.7.11.1 TRPM6;CHAK2 EC 2.7.11.1;Transient receptor potential cation channel subfamily M member 6;Channel kinase 2;Melastatin-related TRP cation channel 6;Isoform TRPM6b of Transient receptor potential cation channel subfamily M member 6 -TRPM7_HUMAN Q96QT4 Chak1 Chak1 ChaK1 2.7.11.1 TRPM7;CHAK1;LTRPC7 EC 2.7.11.1;Transient receptor potential cation channel subfamily M member 7;Channel-kinase 1;Long transient receptor potential channel 7;LTrpC-7;LTrpC7 -TSSK3_HUMAN Q96PN8 TSSK3 TSSK3 2.7.11.1 TSSK3;SPOGA3;STK22C EC 2.7.11.1;Testis-specific serine/threonine-protein kinase 3;TSK-3;TSSK-3;Testis-specific kinase 3;Serine/threonine-protein kinase 22C -TSSK4_HUMAN Q6SA08 TSSK4 (PSP) TSSK4 2.7.11.1 TSSK4;C14orf20;STK22E;TSSK5 2.7.11.1;Testis-specific serine/threonine-protein kinase 4;TSK-4;TSSK-4;Testis-specific kinase 4;Serine/threonine-protein kinase 22E;Isoform 3 of Testis-specific serine/threonine-protein kinase 4 -TTBK1_HUMAN Q5TCY1 TTBK1 (PSP) TTBK1 2.7.11.1 TTBK1;BDTK;KIAA1855 2.7.11.1;Tau-tubulin kinase 1;Brain-derived tau kinase;Isoform 2 of Tau-tubulin kinase 1 -TTBK2_HUMAN Q6IQ55 TTBK2 (PSP) TTBK2 2.7.11.1 TTBK2;KIAA0847 EC 2.7.11.1;Tau-tubulin kinase 2 -TTK_HUMAN P33981 TTK TTK TTK TTK 2.7.12.1 MPS1;TTK;MPS1L1 2.7.12.1;Dual specificity protein kinase TTK;Phosphotyrosine picked threonine-protein kinase;PYT;Isoform 2 of Dual specificity protein kinase TTK -TXK_HUMAN P42681 TXK TXK TXK Tec_group 2.7.10.2 TXK;PTK4;RLK 2.7.10.2;Tyrosine-protein kinase TXK;Protein-tyrosine kinase 4;Resting lymphocyte kinase -TYK2_HUMAN P29597 Tyk2 Tyk2 Tyk2 Tyk2 2.7.10.2 TYK2 2.7.10.2;Non-receptor tyrosine-protein kinase TYK2 -TYRO3_HUMAN Q06418 Tyro3 (PSP) Tyro3 2.7.10.1 TYRO3;BYK;DTK;RSE;SKY;TIF EC 2.7.10.1;Tyrosine-protein kinase receptor TYRO3;Tyrosine-protein kinase BYK;Tyrosine-protein kinase DTK;Tyrosine-protein kinase RSE;Tyrosine-protein kinase SKY;Tyrosine-protein kinase TIF -UFO_HUMAN P30530 Axl Axl AXL 2.7.10.1 AXL;UFO 2.7.10.1;Tyrosine-protein kinase receptor UFO;AXL oncogene -UHMK1_HUMAN Q8TAS1 KIS KIS KIS 2.7.11.1 UHMK1;KIS;KIST EC 2.7.11.1;Serine/threonine-protein kinase Kist;Kinase interacting with stathmin;PAM COOH-terminal interactor protein 2;P-CIP2;U2AF homology motif kinase 1 -ULK1_HUMAN O75385 ULK1 (PSP) ULK1 2.7.11.1 ULK1;KIAA0722 2.7.11.1;Serine/threonine-protein kinase ULK1;Autophagy-related protein 1 homolog;ATG1;hATG1;Unc-51-like kinase 1 -ULK2_HUMAN Q8IYT8 ULK2 (PSP) ULK2 2.7.11.1 ULK2;KIAA0623 EC 2.7.11.1;Serine/threonine-protein kinase ULK2;Unc-51-like kinase 2 -ULK3_HUMAN Q6PHR2 ULK3 (PSP) ULK3 2.7.11.1 ULK3 EC 2.7.11.1;Serine/threonine-protein kinase ULK3;Unc-51-like kinase 3;Isoform 4 of Serine/threonine-protein kinase ULK3 -VGFR1_HUMAN P17948 FLT1 FLT1 VEGFR1 KDR_FLT1_group 2.7.10.1 FLT1;FLT;FRT;VEGFR1 EC 2.7.10.1;FLT;Vascular endothelial growth factor receptor 1;VEGFR-1;Fms-like tyrosine kinase 1;FLT-1;Tyrosine-protein kinase FRT;Tyrosine-protein kinase receptor FLT;Vascular permeability factor receptor -VGFR2_HUMAN P35968 KDR KDR VEGFR2 KDR_FLT1_group 2.7.10.1 KDR;FLK1;VEGFR2 2.7.10.1;Vascular endothelial growth factor receptor 2;VEGFR-2;Fetal liver kinase 1;FLK-1;Kinase insert domain receptor;KDR;Protein-tyrosine kinase receptor flk-1;CD309;Isoform 2 of Vascular endothelial growth factor receptor 2 -VGFR3_HUMAN P35916 FLT4 FLT4 2.7.10.1 FLT4;VEGFR3 EC 2.7.10.1;Vascular endothelial growth factor receptor 3;VEGFR-3;Fms-like tyrosine kinase 4;FLT-4;Tyrosine-protein kinase receptor FLT4 -VRK1_HUMAN Q99986 VRK1 VRK1 VRK1 2.7.11.1 VRK1 2.7.11.1;Serine/threonine-protein kinase VRK1;Vaccinia-related kinase 1 -VRK2_HUMAN Q86Y07 VRK2 (PSP) VRK2 2.7.11.1 VRK2 2.7.11.1;Serine/threonine-protein kinase VRK2;Vaccinia-related kinase 2 -VRK3_HUMAN Q8IV63 VRK3 (PSP) VRK3 VRK3 Inactive serine/threonine-protein kinase VRK3;Serine/threonine-protein pseudokinase VRK3;Vaccinia-related kinase 3 -WEE1_HUMAN P30291 WEE1 WEE1 Wee1 2.7.10.2 WEE1 EC 2.7.10.2;Wee1-like protein kinase;WEE1hu;Wee1A kinase -WNK1_HUMAN Q9H4A3 WNK1 WNK1 WNK1 2.7.11.1 WNK1;HSN2;KDP;KIAA0344;PRKWNK1 2.7.11.1;p65;Serine/threonine-protein kinase WNK1;Erythrocyte 65 kDa protein;Kinase deficient protein;Protein kinase lysine-deficient 1;Protein kinase with no lysine 1;hWNK1;Isoform 6 of Serine/threonine-protein kinase WNK1 -WNK2_HUMAN Q9Y3S1 WNK2 (PSP) WNK2 2.7.11.1 WNK2;KIAA1760;P/OKcl.13 2.7.11.1;Serine/threonine-protein kinase WNK2;Antigen NY-CO-43;Protein kinase lysine-deficient 2;Protein kinase with no lysine 2;Serologically defined colon cancer antigen 43;Isoform 2 of Serine/threonine-protein kinase WNK2 -WNK3_HUMAN Q9BYP7 WNK3 (PSP) WNK3 2.7.11.1 WNK3;KIAA1566;PRKWNK3 2.7.11.1;Serine/threonine-protein kinase WNK3;Protein kinase lysine-deficient 3;Protein kinase with no lysine 3 -WNK4_HUMAN Q96J92 WNK4 (PSP) WNK4 2.7.11.1 WNK4;PRKWNK4 2.7.11.1;Serine/threonine-protein kinase WNK4;Protein kinase lysine-deficient 4;Protein kinase with no lysine 4;Isoform 2 of Serine/threonine-protein kinase WNK4 -YES_HUMAN P07947 Yes Yes Yes Src_group 2.7.10.2 YES1;YES EC 2.7.10.2;Tyrosine-protein kinase Yes;Proto-oncogene c-Yes;p61-Yes -ZAP70_HUMAN P43403 ZAP70 ZAP70 ZAP70 2.7.10.2 ZAP70;SRK EC 2.7.10.2;Tyrosine-protein kinase ZAP-70;70 kDa zeta-chain associated protein;Syk-related tyrosine kinase;Isoform 3 of Tyrosine-protein kinase ZAP-70
--- a/kinase_metadata.sql Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,209 +0,0 @@ --- add the 'Phosida' site-type name, probably with id 4 -INSERT INTO site_type(type_name) VALUES ('Phosida') -; --- eliminate the table that's about to be defined -DROP TABLE IF EXISTS site_metadata -; --- define the site_metadata table -CREATE TABLE site_metadata( - id INTEGER PRIMARY KEY -, site_type_id INTEGER REFERENCES site_type(id) -, full TEXT UNIQUE ON CONFLICT IGNORE -, abbrev TEXT -, pattern TEXT -, motif TEXT -) -; --- populate the table with initial values -INSERT INTO site_metadata(full, abbrev, site_type_id) - SELECT DISTINCT kinase_map, kinase_map, site_type_id - FROM ppep_gene_site - ORDER BY kinase_map - ; --- change site_type_id to Phosida where appropriate -WITH phoo(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'Phosida' -) -UPDATE site_metadata - SET site_type_id = (SELECT id FROM phoo) - WHERE abbrev LIKE '%_Phosida%' - ; --- fix messy prefixes due to compound HPRD/Phosida -WITH src(id, abbrev) AS ( - WITH RECURSIVE split(id, content, last, rest) AS ( - SELECT id, '', '', full - FROM site_metadata - WHERE site_type_id = ( - SELECT id - FROM site_type - WHERE type_name = 'Phosida' - ) - AND abbrev LIKE '%(HPRD)%' - UNION ALL - SELECT - id, - CASE - WHEN last = '&' - THEN - substr(rest, 1, 1) - ELSE - content || substr(rest, 1, 1) - END, - substr(rest, 1, 1), - substr(rest, 2) - FROM split - WHERE rest <> '' - ) - SELECT - id, substr(rest, 2) - FROM - split - WHERE last = '&' - AND rest NOT LIKE '%&%' -) -UPDATE site_metadata - SET abbrev = src.abbrev - FROM src - WHERE src.id = site_metadata.id - AND site_metadata.abbrev LIKE '%_Phosida%' - ; --- parse out abbreviation and pattern for Phosida -WITH phoo(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'Phosida' -) -UPDATE site_metadata - SET abbrev = substr(abbrev, 1, instr(abbrev,'_Phosida ') - 1), - pattern = substr(abbrev, instr(abbrev,'_Phosida ') + 9) - FROM phoo - WHERE site_type_id = phoo.id - AND abbrev LIKE '%_Phosida%' - ; --- parse out abbreviation and pattern for PhosphoSitePlus -WITH psp(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'PhosphoSite' -) -UPDATE site_metadata - SET abbrev = substr(abbrev, 1, instr(abbrev,'_PhosphoSite') - 1), - pattern = '' - FROM psp - WHERE site_type_id = psp.id - AND abbrev LIKE '%_PhosphoSite%' - ; --- parse out abbreviation and pattern for NetworKIN -WITH ntwrk(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'NetworKIN' -) -UPDATE site_metadata - SET abbrev = substr(abbrev, 1, instr(abbrev,'_NetworKIN') - 1), - pattern = '' - FROM ntwrk - WHERE site_type_id = ntwrk.id - AND abbrev LIKE '%_NetworKIN%' - ; --- fix messy prefixes due to compound HPRD/HPRD -WITH src(id, abbrev) AS ( - WITH RECURSIVE split(id, content, last, rest) AS ( - SELECT id, '', '', full - FROM site_metadata - WHERE site_type_id = ( - SELECT id - FROM site_type - WHERE type_name = 'motif' - ) - AND abbrev LIKE '%(HPRD)%' - UNION ALL - SELECT - id, - CASE - WHEN last = '&' - THEN - substr(rest, 1, 1) - ELSE - content || substr(rest, 1, 1) - END, - substr(rest, 1, 1), - substr(rest, 2) - FROM split - WHERE rest <> '' - ) - SELECT - id, substr(rest, 2) - FROM - split - WHERE - last = '&' AND rest NOT LIKE '%&%' -) --- SELECT src.abbrev, site_metadata.* --- FROM src, site_metadata --- WHERE src.id = site_metadata.id --- AND site_metadata.abbrev LIKE '%(HPRD)%(HPRD)%' --- ; -UPDATE site_metadata - SET abbrev = src.abbrev - FROM src - WHERE src.id = site_metadata.id - AND site_metadata.abbrev LIKE '%(HPRD)%(HPRD)%' - ; --- parse out abbreviation and pattern for motif -WITH mtf(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'motif' -) -UPDATE site_metadata - SET abbrev = substr(abbrev, 1, instr(abbrev,'(HPRD) ') - 1), - pattern = substr(abbrev, instr(abbrev,'(HPRD) ') + 7) - FROM mtf - WHERE site_type_id = mtf.id - AND abbrev LIKE '%(HPRD)%' - ; --- trim off verbosities for motif -WITH mtf(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'motif' -) -UPDATE site_metadata - SET abbrev = substr(abbrev, 1, instr(abbrev,'substrate') - 1), - motif = 'substrate' - FROM mtf - WHERE site_type_id = mtf.id - AND abbrev LIKE '%substrate%' - ; --- trim off verbosities for motif -WITH mtf(id) AS ( - SELECT id - FROM site_type - WHERE type_name = 'motif' -) -UPDATE site_metadata - SET abbrev = substr(abbrev, 1, instr(abbrev,'domain binding motif') - 1), - motif = 'binding' - FROM mtf - WHERE site_type_id = mtf.id - AND abbrev LIKE '%domain binding motif%' - ; - - - - --- DROP TABLE IF EXISTS ppep_gene_siteref --- ; --- --- CREATE TABLE ppep_gene_siteref( --- ppep_id INTEGER REFERENCES ppep(id) --- , gene_names TEXT --- , site_type_id INTEGER REFERENCES site_type(id) --- , site_metadata_id INTEGER REFERENCES site_metadata(id) --- , PRIMARY KEY (ppep_id, site_metadata_id) ON CONFLICT IGNORE --- ); --- -
--- a/kseaapp_demo.R Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,481 +0,0 @@ -# KSEAapp demo using SQLite data source -library(sqldf) # implies that package RSQLite will be available -library(KSEAapp) # implies that package gplots will be available - -# ref: http://adv-r.had.co.nz/Environments.html -# "When creating your own environment, note that you should set its parent -# environment to be the empty environment. This ensures you don't -# accidentally inherit objects from somewhere else." -# Caution: this prevents `with(my_env, expr)` from working when `expr` -# contains anything from the global environment, even operators! -# Hence, `x <- 1; get("x", new_env())` fails by design. -new_env <- function() { - new.env(parent = emptyenv()) -} - -# Adapted from KSEAapp::KSEA.Heatmap to allow specification of output file -ksea_heatmap <- -function( - # the data frame outputs from the KSEA.Scores() function, in list format - score_list, - # a character vector of all the sample names for heatmap annotation: - # - the names must be in the same order as the data in score_list - # - please avoid long names, as they may get cropped in the final image - sample_labels, - # character string of either "p.value" or "FDR" indicating the data column - # to use for marking statistically significant scores - stats, - # a numeric value between 0 and infinity indicating the min. number of - # substrates a kinase must have to be included in the heatmap - m_cutoff, - # a numeric value between 0 and 1 indicating the p-value/FDR cutoff - # for indicating significant kinases in the heatmap - p_cutoff, - # a binary input of TRUE or FALSE, indicating whether or not to perform - # hierarchical clustering of the sample columns - sample_cluster, - # a binary input of TRUE or FALSE, indicating whether or not to export - # the bar plot as a .tiff image into the working directory - export = FALSE -) { - filter_m <- function(dataset, m_cutoff) { - filtered <- dataset[(dataset$m >= m_cutoff), ] - return(filtered) - } - score_list_m <- lapply(score_list, function(...) - filter_m(..., - m_cutoff)) - for (i in seq_len(length(score_list_m))) { - names <- colnames(score_list_m[[i]])[c(2:7)] - colnames(score_list_m[[i]])[c(2:7)] <- - paste(names, i, sep = ".") - } - master <- - Reduce(function(...) - merge(..., by = "Kinase.Gene", all = F), score_list_m) - #ACE if (is.null(master)) return ("No significant kinase genes found") - row.names(master) <- master$Kinase.Gene - columns <- as.character(colnames(master)) - merged_scores <- as.matrix(master[, grep("z.score", columns)]) - colnames(merged_scores) <- sample_labels - merged_stats <- as.matrix(master[, grep(stats, columns)]) - asterisk <- function(matrix) { - new <- data.frame() - for (i in seq_len(nrow(matrix))) { - for (j in seq_len(ncol(matrix))) { - if (matrix[i, j] < p_cutoff) { - new[i, j] <- "*" - } - else { - new[i, j] <- "" - } - } - } - return(new) - } - merged_asterisk <- as.matrix(asterisk(merged_stats)) - create_breaks <- function(merged_scores) { - if (min(merged_scores) < -1.6) { - breaks_neg <- seq(-1.6, 0, length.out = 30) - breaks_neg <- - append(seq(min(merged_scores), -1.6, length.out = 10), breaks_neg) - breaks_neg <- sort(unique(breaks_neg)) - } - else { - breaks_neg <- seq(-1.6, 0, length.out = 30) - } - if (max(merged_scores) > 1.6) { - breaks_pos <- seq(0, 1.6, length.out = 30) - breaks_pos <- - append(breaks_pos, seq(1.6, max(merged_scores), length.out = 10)) - breaks_pos <- sort(unique(breaks_pos)) - } - else { - breaks_pos <- seq(0, 1.6, length.out = 30) - } - breaks_all <- unique(append(breaks_neg, breaks_pos)) - mycol_neg <- - gplots::colorpanel(n = length(breaks_neg), - low = "blue", - high = "white") - mycol_pos <- - gplots::colorpanel(n = length(breaks_pos) - 1, - low = "white", - high = "red") - mycol <- unique(append(mycol_neg, mycol_pos)) - color_breaks <- list(breaks_all, mycol) - return(color_breaks) - } - color_breaks <- create_breaks(merged_scores) - plot_height <- nrow(merged_scores) ^ 0.55 - plot_width <- ncol(merged_scores) ^ 0.7 - draw_heatmap <- function() gplots::heatmap.2( - merged_scores, - Colv = sample_cluster, - scale = "none", - cellnote = merged_asterisk, - notecol = "white", - cexCol = 0.9, - cexRow = 0.9, - srtCol = 45, - notecex = 1.4, - col = color_breaks[[2]], - density.info = "none", - trace = "none", - key = F, - breaks = color_breaks[[1]], - lmat = rbind(c(0, 3), c(2, 1), c(0, 4)), - lhei = c(0.4, 9.5, 0.6), - lwid = c(0.5, 3), - margins = c(2, 6) - ) - if (export == "TRUE") { - png( - "KSEA.Merged.Heatmap.png", - width = plot_width * 300, - height = plot_height * 300, - res = 300, - pointsize = 14 - ) - draw_heatmap() - dev.off() - } - else { - draw_heatmap() - } -} - -# Adapted from KSEAapp::KSEA.Barplot to allow: -# - printing main and sub titles -ksea_barplot <- function( - # The Kinase-Substrate dataset uploaded from the file prefaced with - # "PSP&networkin_" available from github.com/casecpb/KSEA/ - ksdata = KSEAapp::KSData, - # The experimental data file formatted as described in the - # KSEAapp::KSEA.Complete() documentation - px, - # networkin = TRUE means inclusion of networkin predictions - # networkin = FALSE means not to include and to ignore networkin_cutoff - networkin, - # A numeric value between 1 and infinity setting the minimum networkin score - # (can be left out if networkin = FALSE) - networkin_cutoff, - # A numeric value between 0 and infinity indicating the min. # of substrates - # a kinase must have to be included in the bar plot output - m_cutoff, - # A numeric value greater than zero indicating the p-value cutoff for - # indicating significant kinases in the bar plot - p_cutoff, - # A numeric value between 0 and 1 indicating the minimum magnitude of - # z-value cutoff for adding a kinase to the bar plot - z_threshold = 1.0, - # A binary input of TRUE or FALSE, indicating whether or not to export - # the bar plot as a .tiff image into the working directory - export = FALSE, - # This remaing arguments are passed through to barplot - main = "", - sub = "" -) { - if (length(grep(";", px$Residue.Both)) == 0) { - new <- px - colnames(new)[c(2, 4)] <- c("SUB_GENE", "SUB_MOD_RSD") - new$log2_fc <- log2(abs(as.numeric(as.character(new$FC)))) - new <- new[complete.cases(new$log2_fc), ] - } - else { - double <- px[grep(";", px$Residue.Both), ] - residues <- as.character(double$Residue.Both) - residues <- as.matrix(residues, ncol = 1) - split <- strsplit(residues, split = ";") - x <- sapply(split, length) - single <- data.frame( - Protein = rep(double$Protein, x), - Gene = rep(double$Gene, x), - Peptide = rep(double$Peptide, - x), - Residue.Both = unlist(split), - p = rep(double$p, - x), - FC = rep(double$FC, x) - ) - new <- px[-grep(";", px$Residue.Both), ] - new <- rbind(new, single) - colnames(new)[c(2, 4)] <- c("SUB_GENE", "SUB_MOD_RSD") - new$log2_fc <- log2(abs(as.numeric(as.character(new$FC)))) - new <- new[complete.cases(new$log2_fc), ] - } - if (networkin == TRUE) { - ksdata_filterd <- ksdata[grep("[a-z]", ksdata$Source), ] - ksdata_filterd <- ksdata_filterd[ - (ksdata_filterd$networkin_score >= networkin_cutoff), - ] - } - else { - ksdata_filterd <- ksdata[grep("PhosphoSitePlus", ksdata$Source), ] - } - ksdata_dataset <- merge(ksdata_filterd, new) - ksdata_dataset <- ksdata_dataset[order(ksdata_dataset$GENE), ] - ksdata_dataset$uniprot_no_isoform <- sapply( - ksdata_dataset$KIN_ACC_ID, - function(x) unlist(strsplit(as.character(x), split = "-"))[1]) - ksdata_dataset_abbrev <- ksdata_dataset[, c(5, 1, 2, 16:19, 14)] - colnames(ksdata_dataset_abbrev) <- c( - "Kinase.Gene", - "Substrate.Gene", - "Substrate.Mod", - "Peptide", - "p", - "FC", - "log2FC", - "Source" - ) - ksdata_dataset_abbrev <- ksdata_dataset_abbrev[ - order( - ksdata_dataset_abbrev$Kinase.Gene, - ksdata_dataset_abbrev$Substrate.Gene, - ksdata_dataset_abbrev$Substrate.Mod, - ksdata_dataset_abbrev$p - ), - ] - ksdata_dataset_abbrev <- aggregate( - log2FC ~ Kinase.Gene + - Substrate.Gene + Substrate.Mod + Source, - data = ksdata_dataset_abbrev, - FUN = mean - ) - ksdata_dataset_abbrev <- - ksdata_dataset_abbrev[order(ksdata_dataset_abbrev$Kinase.Gene), ] - kinase_list <- as.vector(ksdata_dataset_abbrev$Kinase.Gene) - kinase_list <- as.matrix(table(kinase_list)) - mean_fc <- aggregate( - log2FC ~ Kinase.Gene, - data = ksdata_dataset_abbrev, - FUN = mean - ) - mean_fc <- mean_fc[order(mean_fc[, 1]), ] - mean_fc$m_s <- mean_fc[, 2] - mean_fc$enrichment <- mean_fc$m_s / abs(mean(new$log2_fc, na.rm = T)) - mean_fc$m <- kinase_list - mean_fc$z_score <- ((mean_fc$m_s - mean(new$log2_fc, na.rm = T)) * - sqrt(mean_fc$m)) / sd(new$log2_fc, na.rm = T) - mean_fc$p_value <- pnorm(-abs(mean_fc$z_score)) - mean_fc$fdr <- p.adjust(mean_fc$p_value, method = "fdr") - mean_fc_filtered <- mean_fc[(mean_fc$m >= m_cutoff), -2] - mean_fc_filtered <- - mean_fc_filtered[abs(mean_fc_filtered$z_score) > z_threshold, -2] - mean_fc_filtered <- mean_fc_filtered[order(mean_fc_filtered$z_score), ] - plot_height <- length(mean_fc_filtered$z_score) ^ 0.55 - mean_fc_filtered$color <- "black" - mean_fc_filtered[ - (mean_fc_filtered$p_value < p_cutoff) & (mean_fc_filtered$z_score < 0), - ncol(mean_fc_filtered) - ] <- "blue" - mean_fc_filtered[ - (mean_fc_filtered$p_value < p_cutoff) & (mean_fc_filtered$z_score > 0), - ncol(mean_fc_filtered) - ] <- "red" - draw_barplot <- function() { - barplot( - as.numeric(mean_fc_filtered$z_score), - col = mean_fc_filtered$color, - border = NA, - xpd = F, - cex.names = 0.6, - cex.axis = 0.8, - xlab = "Kinase z-score", - names.arg = mean_fc_filtered$Kinase.Gene, - horiz = T, - las = 1, - main = main, - sub = sub - ) - } - if (export == "TRUE") { - tiff( - "KSEA Bar Plot.tiff", - width = 6 * 300, - height = 300 * plot_height, - res = 300, - pointsize = 13 - ) - par(mai = c(1, 1, 0.4, 0.4)) - draw_barplot() - dev.off() - } - else { - draw_barplot() - } -} - -ksea_app_prep_db <- c( - "mqppep.UT_Phospho_ST_Sites.sqlite", - "mqppep.pST_Sites_NancyDu.sqlite" - )[1] - -db <- dbConnect(RSQLite::SQLite(), ksea_app_prep_db) -contrast_metadata_df <- - sqldf("select * from contrast_lvl_lvl_metadata", connection = db) -rslt <- new_env() -rslt$score_list <- list() -rslt$name_list <- list() -#ACE rslt$usable_contrast_list <- list() -next_index <- 0 -low_fdr_print <- function(i) { - #ACE i <- rslt$usable_contrast_list[[i]] - if (!is.null(rslt$score_list[[i]])) { - display_metadata <- - contrast_metadata_df[i, c(4, 5, 6), drop = FALSE] - colnames(display_metadata) <- - c(paste0(contrast_metadata_df[i, 2], "_trt"), - paste0(contrast_metadata_df[i, 3], "_trt"), - "fold-change" - ) - print(display_metadata, row.names = FALSE) - #ACE print( - #ACE contrast_metadata_df[i, c(2, 4, 3, 5, 6), drop = FALSE], - #ACE row.names = FALSE) - #ACE print(contrast_metadata_df[i, ]) - if (sum(rslt$score_list[[i]]$fdr < 0.05) > 0) { - print( - rslt$score_list[[i]][rslt$score_list[[i]]$fdr < 0.05, ], - row.names = FALSE) - } else { - cat("No kinases enriched with FDR < 0.05\n") - } - } -} -err_na_subscr_df_const <- - "missing values are not allowed in subscripted assignments of data frames" - -for (i_cntrst in seq_len(nrow(contrast_metadata_df))) { - contrast_label <- sprintf( - "%s -> %s", - contrast_metadata_df[i_cntrst, "b_level"], - contrast_metadata_df[i_cntrst, "a_level"] - ) - kseaapp_input <- - sqldf( - x = sprintf(" - SELECT `Protein`, `Gene`, `Peptide`, `Residue.Both`, `p`, `FC` - FROM v_kseaapp_input - WHERE contrast = %d - ", i_cntrst - ), - connection = db - ) - #ACE K_S_links <- - #ACE KSEA.KS_table( - #ACE KSEAapp::KSData, - #ACE kseaapp_input, - #ACE networkin = TRUE, - #ACE networkin_cutoff = 2 - #ACE ) - #ACE print(sprintf("contrast = %d", i_cntrst)) - tryCatch( - expr = { - main_title <- ( - sprintf( - "Change from treatment %s to treatment %s", - contrast_metadata_df[i_cntrst, "b_level"], - contrast_metadata_df[i_cntrst, "a_level"] - ) - ) - sub_title <- ( - sprintf( - "Trt %s = {%s}. Trt %s = {%s}.", - contrast_metadata_df[i_cntrst, "b_level"], - gsub( - pattern = ";", - replacement = ", ", - x = contrast_metadata_df[i_cntrst, "b_samples"], - fixed = TRUE - ), - contrast_metadata_df[i_cntrst, "a_level"], - gsub( - pattern = ";", - replacement = "", - x = contrast_metadata_df[i_cntrst, "a_samples"], - fixed = TRUE - ) - ) - ) - ksea_barplot( - KSEAapp::KSData, - kseaapp_input, - networkin = TRUE, - networkin_cutoff = 2, - m_cutoff = 2, - p_cutoff = 0.05, - export = FALSE, - main = main_title, - sub = sub_title - ) - }, - error = function(e) { - if (tolower(e$message) == err_na_subscr_df_const) { - cat( - sprintf("\nNo scores or plot for contrast '%s' because:\n '%s'\n", - contrast_label, - "There are too many missing or invalid values." - ), - file = stdout() - ) - } else { - cat( - sprintf("\nNo scores or plot for contrast '%s' because:\n '%s'\n", - contrast_label, - e$message - ), - file = stdout() - ) - } - } - ) - tryCatch( - expr = { - ksea_scores <- - KSEA.Scores( - KSEAapp::KSData, - kseaapp_input, - NetworKIN = TRUE, - NetworKIN.cutoff = 2 - ) - - if (0 < sum(!is.nan(ksea_scores$FDR))) { - next_index <- 1 + next_index - rslt$score_list[[next_index]] <- ksea_scores - #ACE rslt$usable_contrast_list[[next_index]] <- i_cntrst - rslt$name_list[[next_index]] <- contrast_label - cat("\n", rslt$name_list[[next_index]], "\n") - low_fdr_print(next_index) - } - }, - error = function(e) str(e) - ) -} -if (length(rslt$score_list) > 0) { - ksea_heatmap( - # the data frame outputs from the KSEA.Scores() function, in list format - score_list = rslt$score_list, - # a character vector of all the sample names for heatmap annotation: - # - the names must be in the same order as the data in score_list - # - please avoid long names, as they may get cropped in the final image - sample_labels = rslt$name_list, - # character string of either "p.value" or "FDR" indicating the data column - # to use for marking statistically significant scores - stats = c("p.value", "FDR")[2], - # a numeric value between 0 and infinity indicating the min. number of - # substrates a kinase must have to be included in the heatmap - m_cutoff = 1, - # a numeric value between 0 and 1 indicating the p-value/FDR cutoff - # for indicating significant kinases in the heatmap - p_cutoff = 0.05, - # a binary input of TRUE or FALSE, indicating whether or not to perform - # hierarchical clustering of the sample columns - sample_cluster = TRUE, - # a binary input of TRUE or FALSE, indicating whether or not to export - # the bar plot as a .tiff image into the working directory - export = FALSE - ) -} -dbDisconnect(db)
--- a/phosphoelm_kinase_upid_desc.lut Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,299 +0,0 @@ -kinase_name uniprot_id description -AAK1 Q2M2I8 AP2 associated kinase 1 -Abl P00519 Proto-oncogene tyrosine-protein kinase ABL1 -Abl2 P42684 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) -Abl_drome P00522 Tyrosine-protein kinase Abl -Ack_drome Q9VZI2 Ack -AFK P80197 Actin-fragmin kinase (Physarum polycephalum) -Akt1_drome Q8INB9 RAC serine/threonine-protein kinase -AKT_group_Caeel Serine/threonine-protein kinase akt group -ALK Q9UM73 Anaplastic lymphoma kinase -AMPK_group -Atg1_drome Q9VU14 Autophagy-specific gene 1 -ATM Q13315 Ataxia telangiectasia mutated -ATR Q13535 Ataxia telangiectasia and Rad3-related protein (FRAP-related protein 1) -Aurora A O14965 Serine/threonine-protein kinase 6 (STK6) -Aurora B Q96GD4 Serine/threonine-protein kinase 12 (AURKB) -Axl P30530 Tyrosine-protein kinase receptor UFO -BCKDK O14874 Branched-chain alpha-ketoacid dehydrogenase kinase -BLK P51451 B lymphoid tyrosine kinase -BMPR1B O00238 bone morphogenetic protein receptor, type IB -BMX P51813 BMX non-receptor tyrosine kinase (Etk) -Brk Q13882 Breast tumor kinase (PTK6) -BRSK1 Q8TDC3 BR serine/threonine kinase 1 (SAD1A) -BTK Q06187 Bruton`s tyrosine kinase (AGMX1) (ATK) (BPK) -Caki_drome Q24210 Calcium/calmodulin-dependent protein kinase -CaM-KI_alpha Q14012 calcium/calmodulin-dependent protein kinase I -CaM-KI_group -CaM-KII_alpha Q9UQM7 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha -CaM-KII_delta Q13557 calcium/calmodulin-dependent protein kinase (CaM kinase) II delta -CaMKII_drome Q00168 Calcium/calmodulin-dependent protein kinase type II alpha chain -CaM-KII_group -CaM-KIV Q16566 calcium/calmodulin-dependent protein kinase (CaM kinase) IV -CaM-KK_alpha Q8N5S9 calcium/calmodulin-dependent protein kinase kinase 1, alpha -CCDPK Q9U5L0 Ca2+/calmodulin-dependent protein kinase II (Suberites domuncula) -CDC2_drome P23572 Cell division protein kinase 1 -CDK1 P06493 Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) GENE=CDC2 -CDK11 Q9BWU1 Cell division cycle 2-like 6 -CDK2 P24941 Cell division protein kinase 2 -CDK3 Q00526 cyclin-dependent kinase 3 -CDK4 P11802 Cell division protein kinase 4 (Cyclin-dependent kinase 4) -CDK5 Q00535 Cell division protein kinase 5 -CDK6 Q00534 cyclin-dependent kinase 6 -CDK7 P50613 Cell division protein kinase 7 (CDK-activating kinase) (TFIIH basal transcription factor complex kinase subunit) -CDK9 P50750 cyclin-dependent kinase 9 (CDC2-related kinase) -CDK_group -CDPK Calcium-dependent protein kinase ( in plants) -Chak1 Q96QT4 transient receptor potential cation channel, subfamily M, member 7 -CHK1 O14757 Serine/threonine-protein kinase Chk1 -CHK2 O96017 CHK2 checkpoint homolog -CK1_alpha P48729 casein kinase 1, alpha 1 -CK1_delta P48730 casein kinase 1, delta -CK1_epsilon P49674 casein kinase 1, epsilon -CK1_group -CK2_alpha P68400 casein kinase 2, alpha 1 polypeptide -CK2_beta -CK2_group -CK_group_Caeel Casein kinase group -CkI_alpha_drome P54367 Casein kinase I isoform alpha -CkII_beta_drome P08182 Casein kinase II subunit beta -CkII_group_drome Casein kinase II group -CLK1 P49759 CDC-like kinase 1 -CSF1R P07333 colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog -Csk P41240 Tyrosine-protein kinase CSK -DAPK1 P53355 death-associated protein kinase 1 -DAPK2 Q9UIK4 death-associated protein kinase 2 -DAPK3 O43293 death-associated protein kinase 3 -DAPK_group -DCAMKL1 O15075 doublecortin and CaM kinase-like 1 -DMPK_group -DNA-PK P78527 DNA-dependent protein kinase catalytic subunit -DYRK1A Q13627 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -DYRK1B Q9Y463 Dual specificity tyrosine-phosphorylation-regulated kinase 1B -DYRK2 Q92630 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -DYRK3 O43781 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -Eg3 kinase member of the KIN1/PAR-1/MARK family -EGFR P00533 Epidermal growth factor receptor (Receptor tyrosine-protein kinase ErbB-1) -EIF2AK2 P19525 Interferon-inducible RNA-dependent protein kinase -EIF2AK3 Q9NZJ5 eukaryotic translation initiation factor 2-alpha kinase 3 -EphA2 P29317 EPH receptor A2 -EphA3 P29320 EPH receptor A3 -EphA4 P54764 EPH receptor A4 -EphA8 P29322 EPH receptor A8 -EphB1 P54762 EPH receptor B1 -EphB2 P29323 EPH receptor B2 -EphB3 P54753 EPH receptor B3 -EphB5 Q07497 Ephrin type-B receptor 5 (Gallus gallus) -ErbB2 P04626 Receptor tyrosine-protein kinase erbB-2 precursor -FAK Q05397 Focal adhesion kinase -Fer P16591 Proto-oncogene tyrosine-protein kinase FER -Fes P07332 Proto-oncogene tyrosine-protein kinase Fes/Fps -FGFR1 P11362 Basic fibroblast growth factor receptor 1 -FGFR3 P22607 Fibroblast growth factor receptor 3 -FGFR4 P22455 fibroblast growth factor receptor 4 -FGFR_group -Fgr P09769 Proto-oncogene tyrosine-protein kinase FGR -FLT1 P17948 Vascular endothelial growth factor receptor 1 (VEGFR-1) -FLT3 P36888 Tyrosine-protein kinase receptor FLT3 (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen) (PDGFR family) -FLT4 P35916 Vascular endothelial growth factor receptor 3 (VEGFR-3) -fu_drome P23647 Serine/threonine-protein kinase fused -Fyn P06241 Proto-oncogene tyrosine-protein kinase Fyn -GRK-1 Q15835 Rhodopsin kinase = GRK1 (G protein-coupled receptor kinase 1) -GRK-2 P25098 G protein-coupled receptor kinase 2 = beta-ARK1 (beta-adrenergic receptor kinase 1) -GRK-3 P35626 G protein-coupled receptor kinase 3 = beta-ARK2 (beta-adrenergic receptor kinase 2) -GRK-4 P32298 G protein-coupled receptor kinase 4 -GRK-5 P34947 G protein-coupled receptor kinase 5 -GRK-6 P43250 G protein-coupled receptor kinase 6 -GRK_group -GSK-3_alpha P49840 glycogen synthase kinase 3 alpha -GSK-3_beta P49841 Glycogen synthase kinase-3 beta -GSK-3_Caeel Q9U2Q9 Glycogen synthase kinase-3 homolog -GSK-3_group -HCK P08631 Tyrosine-protein kinase HCK -HIPK1 Q86Z02 homeodomain interacting protein kinase 1 -HIPK2 Q9H2X6 homeodomain interacting protein kinase 2 -HIPK3 Q9H422 homeodomain interacting protein kinase 3 -hop_drome Q24592 Tyrosine-protein kinase hopscotch -HRI Q9BQI3 Eukaryotic translation initiation factor 2-alpha kinase 1 (GENE: Name=EIF2AK1) -ICK Q9UPZ9 intestinal cell (MAK-like) kinase -IGF1R P08069 Insulin-like growth factor 1 receptor (CD221) -IKK_alpha O15111 conserved helix-loop-helix ubiquitous kinase -IKK_beta O14920 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta -IKK_epsilon Q14164 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon -IKK_group -ILK Q13418 Integrin-linked protein kinase 1 -INSR P06213 Insulin receptor -IRAK1 P51617 interleukin-1 receptor-associated kinase 1 -IRAK4 Q9NWZ3 interleukin-1 receptor-associated kinase 4 -ITK Q08881 Tyrosine-protein kinase ITK/TSK -JAK1 P23458 Janus protein-tyrosine kinase 1 -JAK2 O60674 Janus protein-tyrosine kinase 2 -JAK3 P52333 Janus protein-tyrosine kinase 3 -JAK_group -JNK_group -KDR P35968 Vascular endothelial growth factor receptor 2 (VEGFR-2) -KIS Q8TAS1 Kinase interacting with stathmin -Kit P10721 Mast/stem cell growth factor receptor (SCFR) -KSR1 Q8IVT5 kinase suppressor of ras 1 -Lck P06239 lymphocyte-specific protein tyrosine kinase -LIMK1 P53667 LIM domain kinase 1 -LIMK1_drome -LIMK2 P53671 LIM domain kinase 2 -lit-1_Caeel Q9U9Y8 Serine/threonine kinase NLK -LKB1 Q15831 serine/threonine kinase 11 (LKB1) -LOK O94804 serine/threonine kinase 10 (LOK) -LRRK2 Q5S007 leucine-rich repeat kinase 2 -Lyn P07948 Tyrosine-protein kinase Lyn -MAP2K1 Q02750 mitogen-activated protein kinase kinase 1 (MEK1) -MAP2K2 Q7Z370 mitogen-activated protein kinase kinase 2 (MEK2) -MAP2K3 P46734 mitogen-activated protein kinase kinase 3 (MEK3) -MAP2K4 P45985 mitogen-activated protein kinase kinase 4 (MEK4) -MAP2K6 P52564 mitogen-activated protein kinase kinase 6 (MEK6) -MAP2K7 O14733 mitogen-activated protein kinase kinase 7 -MAP2K_group -MAP3K1 Q13233 mitogen-activated protein kinase kinase kinase 1 -MAP3K11 Q16584 mitogen-activated protein kinase kinase kinase 11 -MAP3K14 Q99558 mitogen-activated protein kinase kinase kinase 14 -MAP3K5 Q99683 mitogen-activated protein kinase kinase kinase 5 (ASK1) -MAP3K7 O43318 mitogen-activated protein kinase kinase kinase 7 -MAP3K8 P41279 Mitogen-activated protein kinase kinase kinase 8 -MAP3K_group -MAP4K1 Q92918 mitogen-activated protein kinase kinase kinase kinase 1 (HPK1) -MAP4K2 Q12851 mitogen-activated protein kinase kinase kinase kinase 2 -MAPK1 P28482 mitogen-activated protein kinase 1 (Erk2) -MAPK10 P53779 mitogen-activated protein kinase 10 (JNK3) -MAPK11 Q15759 mitogen-activated protein kinase 11 (p38beta) -MAPK12 P53778 mitogen-activated protein kinase 12 (p38gamma) -MAPK13 O15264 mitogen-activated protein kinase 13 (p38delta) -MAPK14 Q16539 mitogen-activated protein kinase 14 (p38alpha) -MAPK3 P27361 mitogen-activated protein kinase 3 (Erk1) -MAPK4 P31152 mitogen-activated protein kinase 4 (Erk4) -MAPK6 Q16659 mitogen-activated protein kinase 6 (Erk3) -MAPK7 Q13164 mitogen-activated protein kinase 7 (Erk5) -MAPK8 P45983 mitogen-activated protein kinase 8 (JNK1) -MAPK9 P45984 mitogen-activated protein kinase 9 (JNK3 -MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 -MAPKAPK5 Q8IW41 mitogen-activated protein kinase-activated protein kinase 5 -MAPK_group -mapk_group_drome MAPK kinase group -MARK_group -mbk-2_Caeel Q9XTF3 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 -Mer Q12866 Proto-oncogene tyrosine-protein kinase MER -Met P08581 Hepatocyte growth factor receptor -MHCK Myosin heavy chain kinase (Dictyostelium discoideum) -Mlck_drome O01651 Myosin light chain kinase isoform-I -MLCK_group -Mnk1 Q9BUB5 MAP kinase interacting serine/threonine kinase 1 -Mnk2 Q9HBH9 MAP kinase interacting serine/threonine kinase 2 -MOS P00540 v-mos Moloney murine sarcoma viral oncogene homolog -MRCKa Q5VT25 Mytonic dystrophy kinase-related Cdc42-binding kinase -MST1 Q13043 Serine/threonine-protein kinase 4 -MST3 Q9Y6E0 serine/threonine kinase 24 (STE20 homolog, yeast) (MST3) -mTOR P42345 FK506 binding protein 12-rapamycin associated protein 1 -NDR1 Q15208 serine/threonine kinase 38 -NDR2 Q9Y2H1 serine/threonine kinase 38 like -NEK2 P51955 Serine/threonine-protein kinase Nek2 (NimA-related protein kinase 2) -NEK6 Q9HC98 NIMA (never in mitosis gene a)-related kinase 6 -NEK9 Q8TD19 Serine/threonine-protein kinase Nek9 (NimA-related protein kinase 9) -NLK Q9UBE8 Serine/threonine kinase NLK -NuaK1 O60285 NUAK family, SNF1-like kinase, 1 -p38_group -p70S6K P23443 ribosomal protein S6 kinase, 70kDa, polypeptide 1 -p70S6Kb Q9UBS0 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -p70S6K_group -PAK1 Q13153 Serine/threonine-protein kinase PAK1 -PAK2 Q13177 Serine/threonine-protein kinase PAK2 -PAK3 O75914 Serine/threonine-protein kinase PAK3 -PAK5 Q9P286 p21(CDKN1A)-activated kinase 7 -Pak_drome Q24190 Serine/threonine kinase PAK homolog DPAK -PAK_group -PASK Q96RG2 PAS domain containing serine/threonine kinase -PCTAIRE1 Q00536 PCTAIRE protein kinase 1 -PDGFR_alpha P16234 platelet-derived growth factor receptor, alpha polypeptide -PDGFR_beta P09619 platelet-derived growth factor receptor, beta polypeptide -PDGFR_group -PDHK1 Q15118 pyruvate dehydrogenase kinase, isozyme 1 -PDHK2 Q15119 pyruvate dehydrogenase kinase, isozyme 2 -PDHK3 Q15120 pyruvate dehydrogenase kinase, isozyme 3 -PDHK4 Q16654 pyruvate dehydrogenase kinase, isozyme 4 -PDK-1 O15530 3-phosphoinositide dependent protein kinase 1 -PDK-2 -PDKC -PHK_group -PIK3CA -PIK3CB -PIK3CD -PIK3CG -PIM-1 P11309 pim-1 oncogene -PKA_alpha P17612 protein kinase, cAMP-dependent, catalytic, alpha -Pka-C1_drome P12370 cAMP-dependent protein kinase catalytic subunit -PKA_group -PKA_group_drome cAMP-dependent protein kinase catalytic subunit group -PKB_beta P31751 v-akt murine thymoma viral oncogene homolog 2 -PKB_group -PKC_alpha P17252 Protein kinase C, alpha type -PKC_beta P05771 protein kinase C, beta 1 -PKC_delta Q05655 Protein kinase C, delta type -PKC_epsilon Q02156 Protein kinase C, epsilon type -PKC_eta P24723 Protein kinase C, eta -PKC_gamma P05129 protein kinase C, gamma -PKC_group -PKC_group_drome Protein kinase C group -PKC_iota P41743 protein kinase C, iota -PKC_theta Q04759 Protein kinase C, theta type -PKC_zeta Q05513 Protein kinase C, zeta type -PKD1 Q15139 protein kinase D1 -PKD2 Q9BZL6 protein kinase D2 -PKG1/cGK-I P14619 cGMP-dependent protein kinase 1 -PKG2/cGK-II Q13237 cGMP-dependent protein kinase 2 -PKG/cGK_group -PKN1 Q16512 protein kinase N1 -PLK1 P53350 Polo like kinase 1 -PLK3 Q9H4B4 Polo like kinase 3 -PRP4 Q13523 PRP4 pre-mRNA processing factor 4 homolog (yeast) -PYK2 Q14289 Focal adhesion kinase 2 -RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase -RET P07949 Proto-oncogene tyrosine-protein kinase receptor ret -ROCK1 Q13464 Rho-associated, coiled-coil containing protein kinase 1 -ROCK2 O75116 Rho-associated, coiled-coil containing protein kinase 2 -ROCK_group -RON Q04912 Macrophage-stimulating protein receptor ( Stem cell-derived tyrosine kinase) (Mst1r) -RSK-1 Q15418 Ribosomal protein S6 kinase alpha 1 -RSK-2 Q15349 Ribosomal protein S6 kinase alpha 2 -RSK-3 P51812 Ribosomal protein S6 kinase alpha 3 -RSK-5 O75582 ribosomal protein S6 kinase, 90kDa, polypeptide 5 (MSK1) -RSK_group -sgg_drome P83101 Putative glycogen synthase kinase-3 homolog -SGK_group -SIK P57059 SNF1-like kinase -SRC P12931 Proto-oncogene tyrosine-protein kinase Src -SRC64B_drome P00528 Tyrosine-protein kinase Src64B -SRC_group -STLK3 Q9UEW8 Known - Refseq /Serine/threonine-protein kinase 39 -SYK P43405 Tyrosine-protein kinase SYK (Spleen tyrosine kinase). -TBK1 Q9UHD2 TANK-binding kinase 1 -TEC P42680 Tyrosine-protein kinase Tec -TESK1 Q15569 Dual specificity testis-specific protein kinase 1 -TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 -TGFbR1 P36897 TGF-beta receptor type I -TGFbR2 P37173 TGF-beta receptor type II -TIE1 P35590 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -TIE2 Q02763 Angiopoietin-1 receptor precursor (EC 2.7.1.112) (Tyrosine-protein kinase receptor TIE-2) (Tyrosine-protein kinase receptor TEK) -Titin kinase -TLK1 Q9UKI8 tousled-like kinase 1 -TNK2 Q07912 tyrosine kinase, non-receptor, 2 (p21cdc42Hs, ACK) -Tor_drome P18475 Target of rapamycin -TRKA P04629 High affinity nerve growth factor receptor -TRKB Q16620 BDNF/NT-3 growth factors receptor -Tropomyosin kinase Tropomyosin receptor kinase (Gallus gallus) -TSSK3 Q96PN8 testis-specific serine kinase 3 -TTK P33981 TTK protein kinase -TXK P42681 Syn= Rlk -Tyk2 P29597 Non-receptor tyrosine-protein kinase TYK2 -unc-43_Caeel Q9NH60 Calcium/calmodulin-dependent protein kinase II isoform B -VRK1 Q99986 vaccinia related kinase 1 -WEE1 P30291 WEE1 homolog (S. pombe) -WNK1 Q9H4A3 WNK lysine deficient protein kinase 1 -wts_drome Q24590 Serine/threonine kinase PAK homolog DPAK -Yes P07947 Proto-oncogene tyrosine-protein kinase Yes -ZAP70 P43403 Tyrosine-protein kinase ZAP-70
--- a/run_planemo_test.sh Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,8 +0,0 @@ -#!/bin/env bash -WHATTOTEST=$1 - -old_path=$PATH -new_path=`echo $PATH | sed -e "s^/home/rstudio/bin/tinytex:^^"` -export PATH=$new_path - -planemo test --biocontainers --galaxy_root ~/galaxy/thor/planemo_galaxy/galaxyproject-galaxy ${WHATTOTEST:-.}
--- a/run_r_linter.R Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,15 +0,0 @@ -#!/bin/env Rscript -library(lintr) -linters <- linters_with_defaults( - line_length_linter = NULL, - cyclocomp_linter = NULL, - object_usage_linter = NULL -) -cat("linting MaxQuantProcessingScript.R\n") -lint(filename = "MaxQuantProcessingScript.R", linters = linters) -cat("linting mqppep_anova.R\n") -lint(filename = "mqppep_anova.R", linters = linters) -cat("done linting R scripts\n") -cat("linting mqppep_anova_script.Rmd\n") -lint(filename = "mqppep_anova_script.Rmd", linters = linters) -cat("done linting Rmd scripts\n")
--- a/shed.yml Thu Oct 27 18:54:25 2022 +0000 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,24 +0,0 @@ -name: mqppep -owner: eschen42 -description: MaxQuant Phosphoproteomic Enrichment Pipeline - Preprocessing and ANOVA -homepage_url: 'https://github.com/galaxyproteomics/tools-galaxyp/' -long_description: | - Phosphoproteomic Enrichment Pipeline provides tools two tools for processing MaxQuant data for phosphoproteome-enriched samples. - - "MaxQuant Phosphopeptide Preprocessing" (mqppep_preproc) transforms the 'Phospho (STY)Sites.txt' output file that MaxQuant produces for for phosphoproteome-enriched samples to prepare it for ANOVA. - - "MaxQuant Phosphopeptide ANOVA" (mqppep_anova) performs ANOVA on the preprocessed data. -remote_repository_url: https://github.com/galaxyproteomics/tools-galaxyp/tree/master/tools/mqppep -type: unrestricted -categories: -- Proteomics -auto_tool_repositories: - name_template: "{{ tool_id }}" - description_template: "Wrapper for the mqppep suite tool: {{ tool_name }}" -suite: - name: "suite_mqppep" - description: suite for preprocessing, ANOVA, and KSEA of MaxQuant results for phosphoproteomic enrichment - long_description: | - Phosphoproteomic Enrichment Pipeline provides tools for preprocessing - the 'Phospho (ST)Sites.txt' or 'Phospho (Y)Sites.txt' files produced - by MaxQuant and for ANOVA analysis of the preprocessed data.