Mercurial > repos > dvanzessen > vep_emc
changeset 2:17c98d091710 draft
Uploaded
| author | dvanzessen |
|---|---|
| date | Mon, 15 Jul 2019 05:19:31 -0400 |
| parents | 268244627bf2 |
| children | 49397129aec0 |
| files | README.md data_manager/fetch_vep_cache_data.py data_manager/fetch_vep_cache_data.xml data_manager_conf.xml dir_plugins/.hgignore dir_plugins/AncestralAllele.pm dir_plugins/Blosum62.pm dir_plugins/CADD.pm dir_plugins/CCDSFilter.pm dir_plugins/CSN.pm dir_plugins/Carol.pm dir_plugins/Condel.pm dir_plugins/Conservation.pm dir_plugins/DAS.pm dir_plugins/Downstream.pm dir_plugins/Draw.pm dir_plugins/ExAC.pm dir_plugins/ExACpLI.pm dir_plugins/ExACpLI_values.txt dir_plugins/FATHMM.pm dir_plugins/FATHMM_MKL.pm dir_plugins/G2P.pm dir_plugins/GO.pm dir_plugins/GXA.pm dir_plugins/GeneSplicer.pm dir_plugins/HGVSReferenceBase.pm dir_plugins/LD.pm dir_plugins/LICENSE dir_plugins/LOVD.pm dir_plugins/LoFtool.pm dir_plugins/LoFtool_scores.txt dir_plugins/LocalID.pm dir_plugins/MPC.pm dir_plugins/MTR.pm dir_plugins/MaxEntScan.pm dir_plugins/NearestGene.pm dir_plugins/NonSynonymousFilter.pm dir_plugins/PON_P2.pm dir_plugins/Phenotypes.pm dir_plugins/PolyPhen_SIFT.pm dir_plugins/ProteinSeqs.pm dir_plugins/README dir_plugins/REVEL.pm dir_plugins/RankFilter.pm dir_plugins/RefSeqHGVS.pm dir_plugins/SameCodon.pm dir_plugins/SpliceRegion.pm dir_plugins/SubsetVCF.pm dir_plugins/TSSDistance.pm dir_plugins/Wildtype.pm dir_plugins/config/Condel/config/condel_SP.conf dir_plugins/config/Condel/methdist/polyphen.data dir_plugins/config/Condel/methdist/sift.data dir_plugins/config/Condel/methdist/test_condel_SP.data dir_plugins/dbNSFP.pm dir_plugins/dbNSFP_replacement_logic dir_plugins/dbscSNV.pm dir_plugins/miRNA.pm dir_plugins/plugin_config.txt tool-data/vep_cache_data.loc.sample vep.xml |
| diffstat | 61 files changed, 279 insertions(+), 55268 deletions(-) [+] |
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--- a/README.md Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,1 +0,0 @@ -vep
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/data_manager/fetch_vep_cache_data.py Mon Jul 15 05:19:31 2019 -0400 @@ -0,0 +1,70 @@ +import argparse +import os +import json +import re +import pprint +import subprocess +import sys + +if __name__ == "__main__": + parser = argparse.ArgumentParser(description="Use VEP INSTALL.pl to download/process the cache for an assembly") + parser.add_argument("--output-file") + parser.add_argument("--output-dir") + parser.add_argument("--species") + parser.add_argument("--species-type", choices=["ensembl", "refseq", "merged"], default="ensembl") + args = parser.parse_args() + + output_file = args.output_file + output_dir = args.output_dir + + species = args.species + assembly = "" + + if species.startswith("homo_sapiens"): + if species.endswith("37"): + assembly = " --ASSEMBLY GRCh37" + elif species.endswith("38"): + assembly = " --ASSEMBLY GRCh38" + else: + print("Unknown human assembly") + sys.exit(1) + species = "homo_sapiens" + + species_type = args.species_type + if species_type in ["refseq", "merged"]: + species = "{0}_{1}".format(species, species_type) + + with open(output_file) as output_file_handle: + params = json.loads(output_file_handle.read()) + + print(output_file) + print(output_dir) + print(species) + print(species_type) + pprint.pprint(params) + + if not os.path.exists(output_dir): + os.makedirs(output_dir) + + vep_install_cmd = "vep_install --NO_HTSLIB -a alcf --CACHEDIR {0} --SPECIES {1}{2}".format(output_dir, species, assembly) + + print("Running INSTALL.pl") + print(vep_install_cmd) + exit_code = subprocess.call(vep_install_cmd, cwd=output_dir, shell=True) + + print(exit_code) + + output_dict = dict( + data_tables=dict( + vep_cache_data=[{ + "value": species, + "path": output_dir, + "dbkey": args.species, + "type": species_type, + "name": "{0} ({1})".format(args.species, species_type) + }] + ) + ) + with open(output_file, 'w') as output_file_handle: + output_file_handle.write(json.dumps(output_dict)) + sys.exit(exit_code) \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/data_manager/fetch_vep_cache_data.xml Mon Jul 15 05:19:31 2019 -0400 @@ -0,0 +1,182 @@ +<tool id="fetch_vep_cache_data" name="VEP Cache" version="0.0.1" tool_type="manage_data"> + <requirements> + <requirement type="package" version="94.5">ensembl-vep</requirement> + </requirements> + <description>fetching</description> + + <command detect_errors="exit_code"> +python $__tool_directory__/fetch_vep_cache_data.py +--output-file ${ out_file } +--output-dir ${ out_file.extra_files_path } +--species ${ species } +--species-type ${ species_type } + </command> + <inputs> + <param name="species" type="select" label="Species"> + <option value="homo_sapiens37">homo_sapiens (GRCh37)</option> + <option value="homo_sapiens38">homo_sapiens (GRCh38)</option> + <option value="orycteropus_afer_afer">orycteropus_afer_afer</option> + <option value="mus_spretus">mus_spretus</option> + <option value="vicugna_pacos">vicugna_pacos</option> + <option value="poecilia_formosa">poecilia_formosa</option> + <option value="colobus_angolensis_palliatus">colobus_angolensis_palliatus</option> + <option value="anolis_carolinensis">anolis_carolinensis</option> + <option value="dasypus_novemcinctus">dasypus_novemcinctus</option> + <option value="scleropages_formosus">scleropages_formosus</option> + <option value="labrus_bergylta">labrus_bergylta</option> + <option value="stegastes_partitus">stegastes_partitus</option> + <option value="periophthalmus_magnuspinnatus">periophthalmus_magnuspinnatus</option> + <option value="rhinopithecus_bieti">rhinopithecus_bieti</option> + <option value="saimiri_boliviensis_boliviensis">saimiri_boliviensis_boliviensis</option> + <option value="pan_paniscus">pan_paniscus</option> + <option value="cavia_aperea">cavia_aperea</option> + <option value="melopsittacus_undulatus">melopsittacus_undulatus</option> + <option value="haplochromis_burtoni">haplochromis_burtoni</option> + <option value="otolemur_garnettii">otolemur_garnettii</option> + <option value="ciona_intestinalis">ciona_intestinalis</option> + <option value="ciona_savignyi">ciona_savignyi</option> + <option value="caenorhabditis_elegans">caenorhabditis_elegans</option> + <option value="cebus_capucinus_imitator">cebus_capucinus_imitator</option> + <option value="felis_catus">felis_catus</option> + <option value="astyanax_mexicanus">astyanax_mexicanus</option> + <option value="ictalurus_punctatus">ictalurus_punctatus</option> + <option value="gallus_gallus">gallus_gallus</option> + <option value="pan_troglodytes">pan_troglodytes</option> + <option value="cricetulus_griseus">cricetulus_griseus</option> + <option value="pelodiscus_sinensis">pelodiscus_sinensis</option> + <option value="anabas_testudineus">anabas_testudineus</option> + <option value="amphiprion_ocellaris">amphiprion_ocellaris</option> + <option value="gadus_morhua">gadus_morhua</option> + <option value="latimeria_chalumnae">latimeria_chalumnae</option> + <option value="propithecus_coquereli">propithecus_coquereli</option> + <option value="bos_taurus">bos_taurus</option> + <option value="macaca_fascicularis">macaca_fascicularis</option> + <option value="fukomys_damarensis">fukomys_damarensis</option> + <option value="octodon_degus">octodon_degus</option> + <option value="canis_lupus_familiaris">canis_lupus_familiaris</option> + <option value="tursiops_truncatus">tursiops_truncatus</option> + <option value="mandrillus_leucophaeus">mandrillus_leucophaeus</option> + <option value="anas_platyrhynchos">anas_platyrhynchos</option> + <option value="astatotilapia_calliptera">astatotilapia_calliptera</option> + <option value="loxodonta_africana">loxodonta_africana</option> + <option value="mustela_putorius_furo">mustela_putorius_furo</option> + <option value="ficedula_albicollis">ficedula_albicollis</option> + <option value="drosophila_melanogaster">drosophila_melanogaster</option> + <option value="takifugu_rubripes">takifugu_rubripes</option> + <option value="nomascus_leucogenys">nomascus_leucogenys</option> + <option value="capra_hircus">capra_hircus</option> + <option value="mesocricetus_auratus">mesocricetus_auratus</option> + <option value="rhinopithecus_roxellana">rhinopithecus_roxellana</option> + <option value="gorilla_gorilla_gorilla">gorilla_gorilla_gorilla</option> + <option value="seriola_dumerili">seriola_dumerili</option> + <option value="cavia_porcellus">cavia_porcellus</option> + <option value="poecilia_reticulata">poecilia_reticulata</option> + <option value="eptatretus_burgeri">eptatretus_burgeri</option> + <option value="papio_hamadryas">papio_hamadryas</option> + <option value="erinaceus_europaeus">erinaceus_europaeus</option> + <option value="equus_caballus">equus_caballus</option> + <option value="procavia_capensis">procavia_capensis</option> + <option value="oryzias_melastigma">oryzias_melastigma</option> + <option value="oryzias_latipes">oryzias_latipes</option> + <option value="dipodomys_ordii">dipodomys_ordii</option> + <option value="petromyzon_marinus">petromyzon_marinus</option> + <option value="panthera_pardus">panthera_pardus</option> + <option value="jaculus_jaculus">jaculus_jaculus</option> + <option value="echinops_telfairi">echinops_telfairi</option> + <option value="chinchilla_lanigera">chinchilla_lanigera</option> + <option value="neolamprologus_brichardi">neolamprologus_brichardi</option> + <option value="aotus_nancymaae">aotus_nancymaae</option> + <option value="macaca_mulatta">macaca_mulatta</option> + <option value="kryptolebias_marmoratus">kryptolebias_marmoratus</option> + <option value="callithrix_jacchus">callithrix_jacchus</option> + <option value="pteropus_vampyrus">pteropus_vampyrus</option> + <option value="myotis_lucifugus">myotis_lucifugus</option> + <option value="amphilophus_citrinellus">amphilophus_citrinellus</option> + <option value="xiphophorus_couchianus">xiphophorus_couchianus</option> + <option value="mus_musculus">mus_musculus</option> + <option value="mus_musculus_castaneus">mus_musculus_castaneus</option> + <option value="microcebus_murinus">microcebus_murinus</option> + <option value="mus_musculus_musculus">mus_musculus_musculus</option> + <option value="mus_musculus_domesticus">mus_musculus_domesticus</option> + <option value="fundulus_heteroclitus">fundulus_heteroclitus</option> + <option value="heterocephalus_glaber">heterocephalus_glaber</option> + <option value="peromyscus_maniculatus_bairdii">peromyscus_maniculatus_bairdii</option> + <option value="esox_lucius">esox_lucius</option> + <option value="mola_mola">mola_mola</option> + <option value="papio_anubis">papio_anubis</option> + <option value="monodelphis_domestica">monodelphis_domestica</option> + <option value="amphiprion_percula">amphiprion_percula</option> + <option value="pongo_abelii">pongo_abelii</option> + <option value="chrysemys_picta_bellii">chrysemys_picta_bellii</option> + <option value="ailuropoda_melanoleuca">ailuropoda_melanoleuca</option> + <option value="paramormyrops_kingsleyae">paramormyrops_kingsleyae</option> + <option value="sus_scrofa">sus_scrofa</option> + <option value="sus_scrofa_map">sus_scrofa_map</option> + <option value="macaca_nemestrina">macaca_nemestrina</option> + <option value="ochotona_princeps">ochotona_princeps</option> + <option value="xiphophorus_maculatus">xiphophorus_maculatus</option> + <option value="ornithorhynchus_anatinus">ornithorhynchus_anatinus</option> + <option value="microtus_ochrogaster">microtus_ochrogaster</option> + <option value="pundamilia_nyererei">pundamilia_nyererei</option> + <option value="oryctolagus_cuniculus">oryctolagus_cuniculus</option> + <option value="rattus_norvegicus">rattus_norvegicus</option> + <option value="pygocentrus_nattereri">pygocentrus_nattereri</option> + <option value="ceratotherium_simum_simum">ceratotherium_simum_simum</option> + <option value="mus_caroli">mus_caroli</option> + <option value="saccharomyces_cerevisiae">saccharomyces_cerevisiae</option> + <option value="poecilia_latipinna">poecilia_latipinna</option> + <option value="ovis_aries">ovis_aries</option> + <option value="cyprinodon_variegatus">cyprinodon_variegatus</option> + <option value="poecilia_mexicana">poecilia_mexicana</option> + <option value="sorex_araneus">sorex_araneus</option> + <option value="mus_pahari">mus_pahari</option> + <option value="choloepus_hoffmanni">choloepus_hoffmanni</option> + <option value="cercocebus_atys">cercocebus_atys</option> + <option value="physter_macrocephalus">physter_macrocephalus</option> + <option value="acanthochromis_polyacanthus">acanthochromis_polyacanthus</option> + <option value="lepisosteus_oculatus">lepisosteus_oculatus</option> + <option value="ictidomys_tridecemlineatus">ictidomys_tridecemlineatus</option> + <option value="gasterosteus_aculeatus">gasterosteus_aculeatus</option> + <option value="monopterus_albus">monopterus_albus</option> + <option value="carlito_syrichta">carlito_syrichta</option> + <option value="sarcophilus_harrisii">sarcophilus_harrisii</option> + <option value="tetraodon_nigroviridis">tetraodon_nigroviridis</option> + <option value="panthera_tigris_altaica">panthera_tigris_altaica</option> + <option value="hippocampus_comes">hippocampus_comes</option> + <option value="oreochromis_niloticus">oreochromis_niloticus</option> + <option value="cynoglossus_semilaevis">cynoglossus_semilaevis</option> + <option value="tupaia_belangeri">tupaia_belangeri</option> + <option value="scophthalmus_maximus">scophthalmus_maximus</option> + <option value="meleagris_gallopavo">meleagris_gallopavo</option> + <option value="nannospalax_galili">nannospalax_galili</option> + <option value="chlorocebus_sabaeus">chlorocebus_sabaeus</option> + <option value="notamacropus_eugenii">notamacropus_eugenii</option> + <option value="gambusia_affinis">gambusia_affinis</option> + <option value="xenopus_tropicalis">xenopus_tropicalis</option> + <option value="seriola_lalandi_dorsalis">seriola_lalandi_dorsalis</option> + <option value="taeniopygia_guttata">taeniopygia_guttata</option> + <option value="maylandia_zebra">maylandia_zebra</option> + <option value="danio_rerio">danio_rerio</option> + <option value="mastacembelus_armatus">mastacembelus_armatus</option> + <option value=""></option> + </param> + <param name="species_type" type="select" label="Get the Ensembl, Refseq or merged Ensembl/Refseq"> + <option value="ensembl" selected="true">Ensembl</option> + <option value="refseq">Refseq</option> + <option value="merged">Merged</option> + </param> + </inputs> + <outputs> + <data name="out_file" format="data_manager_json"/> + </outputs> + <!-- + <tests> + <test> + DON'T FORGET TO DEFINE SOME TOOL TESTS + </test> + </tests> + --> + <help> + There is no help + </help> +</tool> \ No newline at end of file
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/data_manager_conf.xml Mon Jul 15 05:19:31 2019 -0400 @@ -0,0 +1,20 @@ +<?xml version="1.0"?> +<data_managers> + <data_manager tool_file="data_manager/fetch_vep_cache_data.xml" id="fetch_vep_cache_data"> + <data_table name="vep_cache_data"> + <output> + <column name="value" /> + <column name="dbkey" /> + <column name="type" /> + <column name="name" /> + <column name="path" output_ref="out_file" > + <move type="directory"> + <source>${path}</source> + <target base="${GALAXY_DATA_MANAGER_DATA_PATH}">${dbkey}/seq/${path}</target> + </move> + <value_translation>${GALAXY_DATA_MANAGER_DATA_PATH}/${dbkey}/seq/${path}</value_translation> + </column> + </output> + </data_table> + </data_manager> +</data_managers>
--- a/dir_plugins/.hgignore Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,2 +0,0 @@ -syntax: glob -*~
--- a/dir_plugins/AncestralAllele.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,281 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - AncestralAllele - -=head1 SYNOPSIS - - mv AncestralAllele.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin AncestralAllele,homo_sapiens_ancestor_GRCh38_e86.fa.gz - -=head1 DESCRIPTION - - A VEP plugin that retrieves ancestral allele sequences from a FASTA file. - - Ensembl produces FASTA file dumps of the ancestral sequences of key species. - They are available from ftp://ftp.ensembl.org/pub/current_fasta/ancestral_alleles/ - - For optimal retrieval speed, you should pre-process the FASTA files into a single - bgzipped file that can be accessed via Bio::DB::HTS::Faidx (installed by VEP's - INSTALL.pl): - - wget ftp://ftp.ensembl.org/pub/release-90/fasta/ancestral_alleles/homo_sapiens_ancestor_GRCh38_e86.tar.gz - tar xfz homo_sapiens_ancestor_GRCh38_e86.tar.gz - cat homo_sapiens_ancestor_GRCh38_e86/*.fa | bgzip -c > homo_sapiens_ancestor_GRCh38_e86.fa.gz - rm -rf homo_sapiens_ancestor_GRCh38_e86/ homo_sapiens_ancestor_GRCh38_e86.tar.gz - ./vep -i variations.vcf --plugin AncestralAllele,homo_sapiens_ancestor_GRCh38_e86.fa.gz - - The plugin is also compatible with Bio::DB::Fasta and an uncompressed FASTA file. - - Note the first time you run the plugin with a newly generated FASTA file it will - spend some time indexing the file. DO NOT INTERRUPT THIS PROCESS, particularly - if you do not have Bio::DB::HTS installed. - - Special cases: - "-" represents an insertion - "?" indicates the chromosome could not be looked up in the FASTA - -=cut - -package AncestralAllele; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -our $CAN_USE_FAIDX; -our $DEBUG = 0; - -BEGIN { - if (eval { require Bio::DB::HTS::Faidx; 1 }) { - $CAN_USE_FAIDX = 1; - } -} - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # get file - my $fasta_file = $self->params->[0] || ""; - die("ERROR: Ancestral FASTA file $fasta_file not provided or found\n") unless $fasta_file && -e $fasta_file; - $self->fasta_file($fasta_file); - - # get type of index we're creating/using - my $type = $fasta_file =~ /\.gz$/ ? 'Bio::DB::HTS::Faidx' : 'Bio::DB::Fasta'; - die("ERROR: Bio::DB::HTS required to access compressed FASTA file $fasta_file\n") if $type eq 'Bio::DB::HTS::Faidx' && !$CAN_USE_FAIDX; - $self->index_type($type); - - # init DB here so indexing doesn't happen at some point in the middle of VEP run - $self->fasta_db; - - return $self; -} - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - return { AA => 'Ancestral allele from '.$_[0]->fasta_file } -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - my ($start, $end) = ($vf->{start}, $vf->{end}); - - # cache AA on VF, prevents repeat lookups for multiple TVAs - if(!exists($vf->{_vep_plugin_AncestralAllele})) { - - # insertion - return { AA => $vf->{_vep_plugin_AncestralAllele} = '-' } if $start > $end; - - my $sr_name = $self->get_sr_name($vf->{chr}); - - # chr not in FASTA - return { AA => $vf->{_vep_plugin_AncestralAllele} = '?' } unless $sr_name; - - my $fasta_db = $self->fasta_db; - my $type = $self->index_type; - my ($seq, $length); - - if($type eq 'Bio::DB::HTS::Faidx') { - my $location_string = $sr_name.":".$start."-".$end ; - ($seq, $length) = $fasta_db->get_sequence($location_string); - } - elsif($type eq 'Bio::DB::Fasta') { - $seq = $fasta_db->seq($sr_name, $start => $end); - } - else { - throw("ERROR: Don't know how to fetch sequence from a ".ref($fasta_db)."\n"); - } - - reverse_comp(\$seq) if $vf->{strand} < 0; - - $vf->{_vep_plugin_AncestralAllele} = $seq; - } - - return { AA => $vf->{_vep_plugin_AncestralAllele} }; -} - -# getter/setter for fasta file path -sub fasta_file { - my $self = shift; - $self->{_fasta_file} = shift if @_; - return $self->{_fasta_file}; -} - -# getter/setter for fasta index type -sub index_type { - my $self = shift; - $self->{_index_type} = shift if @_; - return $self->{_index_type}; -} - -## CRIBBED FROM Bio::EnsEMBL::Variation::Utils::FastaSequence -## MOVE THIS CODE TO SHARED UTILS SPACE? -# creates the FASTA DB object -# returns either a Bio::DB::Fasta or a Bio::DB::HTS::Faidx -# uses a lock file to avoid partial indexes getting used -sub fasta_db { - my $self = shift; - - # if we've forked we need to re-connect - # but make sure we only do this once per fork - my $prev_pid = $self->{_prev_pid} ||= $$; - if($prev_pid ne $$) { - delete $self->{_fasta_db}; - $self->{_prev_pid} = $$; - } - - if(!exists($self->{_fasta_db})) { - my $fasta = $self->fasta_file; - my $type = $self->index_type; - - # check lock file - my $lock_file = $fasta; - $lock_file .= -d $fasta ? '/.vep.lock' : '.vep.lock'; - - # lock file exists, indexing failed - if(-e $lock_file) { - print STDERR "Lock file found, removing to allow re-indexing\n" if $DEBUG; - for(qw(.fai .index .gzi /directory.index /directory.fai .vep.lock)) { - unlink($fasta.$_) if -e $fasta.$_; - } - } - - my $index_exists = 0; - - for my $fn(map {$fasta.$_} qw(.fai .index .gzi /directory.index /directory.fai)) { - if(-e $fn) { - $index_exists = 1; - last; - } - } - - # create lock file - unless($index_exists) { - open LOCK, ">$lock_file" or throw("ERROR: Could not write to FASTA lock file $lock_file\n"); - print LOCK "1\n"; - close LOCK; - print STDERR "Indexing $fasta\n" if $DEBUG; - } - - # run indexing - my $fasta_db; - if($type eq 'Bio::DB::HTS::Faidx' && $CAN_USE_FAIDX) { - $fasta_db = Bio::DB::HTS::Faidx->new($fasta); - } - elsif(!$type || $type eq 'Bio::DB::Fasta') { - $fasta_db = Bio::DB::Fasta->new($fasta); - } - else { - throw("ERROR: Don't know how to index with type $type\n"); - } - print STDERR "Finished indexing\n" if $DEBUG; - - throw("ERROR: Unable to create FASTA DB\n") unless $fasta_db; - - # remove lock file - unlink($lock_file) unless $index_exists; - - $self->{_fasta_db} = $fasta_db; - } - - return $self->{_fasta_db}; -} - -# gets seq region name as it appears in the FASTA -# the file contains names like "ANCESTOR_for_chromosome:GRCh38:10:1:133797422:1" -# so want to map from "10" or "chr10" to "ANCESTOR_for_chromosome:GRCh38:10:1:133797422:1" -sub get_sr_name { - my $self = shift; - my $sr_name = shift; - - my $map = $self->fasta_name_map; - my $fasta_db = $self->fasta_db; - - unless($map->{$sr_name}) { - foreach my $alt( - $sr_name =~ /^chr/i ? (substr($sr_name, 3)) : ('chr'.$sr_name, 'CHR'.$sr_name) - ) { - if($map->{$alt}) { - print STDERR "USING SYNONYM $alt FOR $sr_name\n" if $DEBUG; - $sr_name = $alt; - last; - } - } - } - - return $map->{$sr_name} || undef; -} - -sub fasta_name_map { - my ($self, $chr) = @_; - - if(!exists($self->{_name_map})) { - my $fasta_db = $self->fasta_db; - - my %map = map {(split(':', $_))[2] => $_} - $fasta_db->isa('Bio::DB::Fasta') ? - (grep {$_ !~ /^\_\_/} $fasta_db->get_all_primary_ids) : - ($fasta_db->get_all_sequence_ids); - - $self->{_name_map} = \%map; - } - - return $self->{_name_map}; -} - -1;
--- a/dir_plugins/Blosum62.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,125 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Blosum62 - -=head1 SYNOPSIS - - mv Blosum62.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Blosum62 - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - looks up the BLOSUM 62 substitution matrix score for the reference - and alternative amino acids predicted for a missense mutation. It adds - one new entry to the VEP's Extra column, BLOSUM62 which is the - associated score. - -=cut - -package Blosum62; - -use strict; -use warnings; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -my @BLOSUM_62 = qw( - 4 -1 -2 -2 0 -1 -1 0 -2 -1 -1 -1 -1 -2 -1 1 0 -3 -2 0 --1 5 0 -2 -3 1 0 -2 0 -3 -2 2 -1 -3 -2 -1 -1 -3 -2 -3 --2 0 6 1 -3 0 0 0 1 -3 -3 0 -2 -3 -2 1 0 -4 -2 -3 --2 -2 1 6 -3 0 2 -1 -1 -3 -4 -1 -3 -3 -1 0 -1 -4 -3 -3 - 0 -3 -3 -3 9 -3 -4 -3 -3 -1 -1 -3 -1 -2 -3 -1 -1 -2 -2 -1 --1 1 0 0 -3 5 2 -2 0 -3 -2 1 0 -3 -1 0 -1 -2 -1 -2 --1 0 0 2 -4 2 5 -2 0 -3 -3 1 -2 -3 -1 0 -1 -3 -2 -2 - 0 -2 0 -1 -3 -2 -2 6 -2 -4 -4 -2 -3 -3 -2 0 -2 -2 -3 -3 --2 0 1 -1 -3 0 0 -2 8 -3 -3 -1 -2 -1 -2 -1 -2 -2 2 -3 --1 -3 -3 -3 -1 -3 -3 -4 -3 4 2 -3 1 0 -3 -2 -1 -3 -1 3 --1 -2 -3 -4 -1 -2 -3 -4 -3 2 4 -2 2 0 -3 -2 -1 -2 -1 1 --1 2 0 -1 -3 1 1 -2 -1 -3 -2 5 -1 -3 -1 0 -1 -3 -2 -2 --1 -1 -2 -3 -1 0 -2 -3 -2 1 2 -1 5 0 -2 -1 -1 -1 -1 1 --2 -3 -3 -3 -2 -3 -3 -3 -1 0 0 -3 0 6 -4 -2 -2 1 3 -1 --1 -2 -2 -1 -3 -1 -1 -2 -2 -3 -3 -1 -2 -4 7 -1 -1 -4 -3 -2 - 1 -1 1 0 -1 0 0 0 -1 -2 -2 0 -1 -2 -1 4 1 -3 -2 -2 - 0 -1 0 -1 -1 -1 -1 -2 -2 -1 -1 -1 -1 -2 -1 1 5 -2 -2 0 --3 -3 -4 -4 -2 -2 -3 -2 -2 -3 -2 -3 -1 1 -4 -3 -2 11 2 -3 --2 -2 -2 -3 -2 -1 -2 -3 2 -1 -1 -2 -1 3 -3 -2 -2 2 7 -1 - 0 -3 -3 -3 -1 -2 -2 -3 -3 3 1 -2 1 -1 -2 -2 0 -3 -1 4 -); - -my @AAs = qw(A R N D C Q E G H I L K M F P S T W Y V); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # construct a hash representing the matrix for quick lookups - - my $num = @AAs; - - for (my $i = 0; $i < $num; $i++) { - for (my $j = 0; $j < $num; $j++) { - $self->{matrix}->{$AAs[$i]}->{$AAs[$j]} = $BLOSUM_62[($i * $num) + $j]; - } - } - - return $self; -} - -sub version { - return '2.3'; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - BLOSUM62 => "BLOSUM62 substitution score for the reference and alternative amino acids", - }; -} - -sub run { - my ($self, $tva) = @_; - - if ($tva->pep_allele_string && $tva->pep_allele_string =~ /^([A-Z])\/([A-Z])$/) { - - my $score = $self->{matrix}->{$1}->{$2}; - - if (defined $score) { - return { - BLOSUM62 => $score - }; - } - } - - return {}; -} - -1; -
--- a/dir_plugins/CADD.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,137 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - CADD - -=head1 SYNOPSIS - - mv CADD.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin CADD,whole_genome_SNVs.tsv.gz,InDels.tsv.gz - -=head1 DESCRIPTION - - A VEP plugin that retrieves CADD scores for variants from one or more - tabix-indexed CADD data files. - - Please cite the CADD publication alongside the VEP if you use this resource: - http://www.ncbi.nlm.nih.gov/pubmed/24487276 - - The tabix utility must be installed in your path to use this plugin. The CADD - data files can be downloaded from - http://cadd.gs.washington.edu/download - -=cut - -package CADD; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - - $self->get_user_params(); - - return $self; -} - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - my $self = shift; - return { - CADD_PHRED => 'PHRED-like scaled CADD score', - CADD_RAW => 'Raw CADD score' - } -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - # get allele, reverse comp if needed - my $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - return {} unless $allele =~ /^[ACGT-]+$/; - - my ($res) = grep { - $_->{alt} eq $allele && - $_->{start} eq $vf->{start} && - $_->{end} eq $vf->{end} - } @{$self->get_data($vf->{chr}, $vf->{start} - 2, $vf->{end})}; - - return $res ? $res->{result} : {}; -} - -sub parse_data { - my ($self, $line) = @_; - - my ($c, $s, $ref, $alt, $raw, $phred) = split /\t/, $line; - - # do VCF-like coord adjustment for mismatched subs - my $e = ($s + length($ref)) - 1; - if(length($alt) != length($ref)) { - $s++; - $ref = substr($ref, 1); - $alt = substr($alt, 1); - $ref ||= '-'; - $alt ||= '-'; - } - - return { - alt => $alt, - start => $s, - end => $e, - result => { - CADD_RAW => $raw, - CADD_PHRED => $phred - } - }; -} - -sub get_start { - return $_[1]->{start}; -} - -sub get_end { - return $_[1]->{end}; -} - -1; \ No newline at end of file
--- a/dir_plugins/CCDSFilter.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,62 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - CCDSFilter - -=head1 SYNOPSIS - - mv CCDSFilter.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin CCDSFilter - -=head1 DESCRIPTION - - A simple VEP filter plugin that limits output to variants that - fall in transcripts which have CCDS coding sequences. - -=cut - -package CCDSFilter; - -use strict; -use warnings; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepFilterPlugin); - -sub feature_types { - return ['Transcript']; -} - -sub include_line { - my ($self, $tva) = @_; - - my $t = $tva->transcript; - - my @entries = grep {$_->database eq 'CCDS'} @{$t->get_all_DBEntries}; - - return scalar @entries; -} - -1; -
--- a/dir_plugins/CSN.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,122 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - CSN - -=head1 SYNOPSIS - - mv CSN.pm ~/.vep/Plugins - ./vep -i variations.vcf --cache --plugin CSN - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - reports Clinical Sequencing Nomenclature (CSN) for variants. - - Each notation is given with reference to the transcript identifier; - specify "--plugin CSN,1" to remove this identifier from the CSN string. - - You may also wish to specify "--no_escape" to prevent the "=" in "p.=" - notations being converted to the URI-escaped equivalent "p.%3D"; doing - so may break parsers looking for "=" as a KEY=VALUE separator. - - See http://biorxiv.org/content/early/2015/03/21/016808.1 - -=cut - -package CSN; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; -use Bio::EnsEMBL::Variation::DBSQL::TranscriptVariationAdaptor; -use Bio::EnsEMBL::Variation::DBSQL::DBAdaptor; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # check config is OK - - # FASTA file defined, optimal - if(!defined($self->{config}->{fasta})) { - - # offline mode won't work without FASTA - die("ERROR: Cannot generate CSN without either a FASTA file (--fasta) or a database connection (--cache or --database)\n") if defined($self->{config}->{offline}) and !defined($self->{config}->{quiet}); - - # cache mode will work, but DB will be accessed - warn("WARNING: Database will be accessed using this plugin; use a FASTA file (--fasta) for optimal performance") if defined($self->{config}->{cache}) and !defined($self->{config}->{quiet}); - } - - no warnings 'once'; - $Bio::EnsEMBL::Variation::DBSQL::TranscriptVariationAdaptor::DEFAULT_SHIFT_HGVS_VARIANTS_3PRIME = 1; - no warnings 'once'; - $Bio::EnsEMBL::Variation::DBSQL::DBAdaptor::DEFAULT_SHIFT_HGVS_VARIANTS_3PRIME = 1; - - $self->{remove_transcript_ID} = $self->params->[0]; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['VariationFeature']; -} - -sub get_header_info { - return { CSN => 'Clinical Sequencing Nomenclature'}; -} - -sub run { - my ($self, $tva) = @_; - - my ($hgvs_c, $hgvs_p) = ($tva->hgvs_transcript || '', $tva->hgvs_protein || ''); - - return {} unless $hgvs_c; - - # trim off transcript/protein ID - $hgvs_c =~ s/.+\:// if $self->{remove_transcript_ID}; - $hgvs_p =~ s/.+\://; - - # change Ter to X - $hgvs_p =~ s/Ter/X/g; - - # leave just p.= - $hgvs_p = 'p.=' if $hgvs_p =~ /p\.\=/; - - # escape - $hgvs_p =~ s/\=/\%3D/g unless $self->{config}->{no_escape}; - - return { CSN => $hgvs_c.($hgvs_p ? '_'.$hgvs_p : '') }; -} - -1;
--- a/dir_plugins/Carol.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,177 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Carol - -=head1 SYNOPSIS - - mv Carol.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Carol - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that calculates - the Combined Annotation scoRing toOL (CAROL) score (1) for a missense mutation - based on the pre-calculated SIFT (2) and PolyPhen-2 (3) scores from the Ensembl - API (4). It adds one new entry class to the VEP's Extra column, CAROL which is - the calculated CAROL score. Note that this module is a perl reimplementation of - the original R script, available at: - - http://www.sanger.ac.uk/resources/software/carol/ - - I believe that both versions implement the same algorithm, but if there are any - discrepancies the R version should be treated as the reference implementation. - Bug reports are welcome. - - References: - - (1) Lopes MC, Joyce C, Ritchie GRS, John SL, Cunningham F, Asimit J, Zeggini E. - A combined functional annotation score for non-synonymous variants - Human Heredity (in press) - - (2) Kumar P, Henikoff S, Ng PC. - Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm - Nature Protocols 4(8):1073-1081 (2009) - doi:10.1038/nprot.2009.86 - - (3) Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. - A method and server for predicting damaging missense mutations - Nature Methods 7(4):248-249 (2010) - doi:10.1038/nmeth0410-248 - - (4) Flicek P, et al. - Ensembl 2012 - Nucleic Acids Research (2011) - doi: 10.1093/nar/gkr991 - -=cut - -package Carol; - -use strict; -use warnings; - -use Math::CDF qw(pnorm qnorm); - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -my $CAROL_CUTOFF = 0.98; - -sub version { - return '2.3'; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - CAROL => "Combined Annotation scoRing toOL prediction", - }; -} - -sub run { - my ($self, $tva) = @_; - - my $pph_pred = $tva->polyphen_prediction; - my $pph_score = $pph_pred ? ($pph_pred eq 'unknown' ? undef: $tva->polyphen_score) : undef; - my $sift_score = $tva->sift_score; - - my ($carol_pred, $carol_score) = compute_carol($pph_score, $sift_score); - - my $results = {}; - - if (defined $carol_pred) { - - $carol_score = sprintf "%.3f", $carol_score; - - my $result = "$carol_pred($carol_score)"; - - if (@{ $self->params } > 0) { - $result = $carol_pred if ($self->params->[0] =~ /^p/i); - $result = $carol_score if ($self->params->[0] =~ /^s/i); - } - - $results = { - CAROL => $result, - }; - } - - return $results; -} - -sub compute_carol { - - my ($pph_score, $sift_score) = @_; - - my $carol_score; - - if (defined $pph_score) { - $pph_score = 0.999 if $pph_score == 1; - $pph_score = 0.0001 if $pph_score == 0; - } - - if (defined $sift_score) { - $sift_score = 1 - $sift_score; - $sift_score = 0.999 if $sift_score == 1; - $sift_score = 0.0001 if $sift_score == 0; - } - - if (defined $pph_score && defined $sift_score) { - - my $pph_weight = log(1/(1-$pph_score)); - my $sift_weight = log(1/(1-$sift_score)); - - # we take -qnorm, because the R script uses qnorm(..., lower.tail = FALSE) - - my $pph_z = -qnorm($pph_score); - my $sift_z = -qnorm($sift_score); - - my $numerator = ($pph_weight * $pph_z) + ($sift_weight * $sift_z); - my $denominator = sqrt( ($pph_weight ** 2) + ($sift_weight ** 2) ); - - # likewise we take 1 - pnorm - - $carol_score = 1 - pnorm($numerator / $denominator); - } - elsif (defined $pph_score) { - $carol_score = $pph_score; - } - else { - $carol_score = $sift_score; - } - - if (defined $carol_score) { - my $carol_pred = $carol_score < $CAROL_CUTOFF ? 'Neutral' : 'Deleterious'; - return ($carol_pred, $carol_score); - } - else { - return undef; - } -} - -1; -
--- a/dir_plugins/Condel.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,261 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Condel - -=head1 SYNOPSIS - - mv Condel.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Condel,/path/to/config/Condel/config,b - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that calculates - the Consensus Deleteriousness (Condel) score (1) for a missense mutation - based on the pre-calculated SIFT (2) and PolyPhen-2 (3) scores from the Ensembl - API (4). It adds one new entry class to the VEP's Extra column, Condel which is - the calculated Condel score. This version of Condel was developed by the Biomedical Genomics Group - of the Universitat Pompeu Fabra, at the Barcelona Biomedical Research Park and available at - (http://bg.upf.edu/condel) until April 2014. The code in this plugin is based on a script provided by this - group and slightly reformatted to fit into the Ensembl API. - - The plugin takes 3 command line arguments, the first is the path to a Condel - configuration directory which contains cutoffs and the distribution files etc., - the second is either "s", "p", or "b" to output the Condel score, prediction or - both (the default is both), and the third argument is either 1 or 2 to use the - original version of Condel (1), or the newer version (2) - 2 is the default and - is recommended to avoid false positive predictions from Condel in some - circumstances. - - An example Condel configuration file and a set of distribution files can be found - in the config/Condel directory in this repository. You should edit the - config/Condel/config/condel_SP.conf file and set the 'condel.dir' parameter to - the full path to the location of the config/Condel directory on your system. - - References: - - (1) Gonzalez-Perez A, Lopez-Bigas N. - Improving the assessment of the outcome of non-synonymous SNVs with a Consensus deleteriousness score (Condel) - Am J Hum Genet 88(4):440-449 (2011) - doi:10.1016/j.ajhg.2011.03.004 - - (2) Kumar P, Henikoff S, Ng PC. - Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm - Nature Protocols 4(8):1073-1081 (2009) - doi:10.1038/nprot.2009.86 - - (3) Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, Kondrashov AS, Sunyaev SR. - A method and server for predicting damaging missense mutations - Nature Methods 7(4):248-249 (2010) - doi:10.1038/nmeth0410-248 - - (4) Flicek P, et al. - Ensembl 2012 - Nucleic Acids Research (2011) - doi: 10.1093/nar/gkr991 - -=cut - -package Condel; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '2.4'; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - Condel => "Consensus deleteriousness score for an amino acid substitution based on SIFT and PolyPhen-2", - }; -} - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # parse the config file and distribution files - - my $config_dir = $self->params->[0]; - $self->{output} = $self->params->[1] || 'b'; - $self->{version} = $self->params->[2] || 2; - - # find config dir - unless($config_dir && -d $config_dir) { - $config_dir = $INC{'Condel.pm'}; - $config_dir =~ s/Condel\.pm/config\/Condel\/config/; - die "ERROR: Unable to find Condel config path\n" unless -d $config_dir; - } - - my $config_file = "$config_dir/condel_SP.conf"; - - open(CONF, "<$config_file") || die "Could not open $config_file"; - - my @conf = <CONF>; - - my $safe_conf = 0; - - for (my $i = 0; $i < @conf; $i++){ - if ($conf[$i] =~ /condel\.dir=\'(\S+)\'/){ - $self->{config}->{'condel.dir'} = $1; - - # user has not edited config, attempt to get correct dir - if($self->{config}->{'condel.dir'} eq 'path/to/config/Condel/') { - my $dir = $INC{'Condel.pm'}; - $dir =~ s/Condel\.pm/config\/Condel/; - $self->{config}->{'condel.dir'} = $dir; - } - $safe_conf++ if -d $self->{config}->{'condel.dir'}; - } - elsif ($conf[$i] =~ /(cutoff\.HumVar\.\w+)=\'(\S+)\'/){ - $self->{config}->{$1} = $2; - $safe_conf++; - } - elsif ($conf[$i] =~ /(max\.HumVar\.\w+)=\'(\S+)\'/){ - $self->{config}->{$1} = $2; - $safe_conf++; - } - } - - if ($safe_conf < 3){ - die "Malformed config file!!!\n\n"; - } - - open(SIFT, $self->{config}->{'condel.dir'}."/methdist/sift.data"); - my @sift = <SIFT>; - close SIFT; - - for (my $i = 0; $i < @sift; $i++){ - if ($sift[$i] =~ /(\S+)\s+(\S+)\s+(\S+)/){ - $self->{sift}->{tp}->{$1} = $2; - $self->{sift}->{tn}->{$1} = $3; - } - } - - open(POLYPHEN, $self->{config}->{'condel.dir'}."/methdist/polyphen.data"); - my @polyphen = <POLYPHEN>; - close POLYPHEN; - - for (my $i = 0; $i < @polyphen; $i++){ - if ($polyphen[$i] =~ /(\S+)\s+(\S+)\s+(\S+)/){ - $self->{polyphen}->{tp}->{$1} = $2; - $self->{polyphen}->{tn}->{$1} = $3; - } - } - - return $self; -} - -sub run { - my ($self, $tva) = @_; - - my $pph_score = $tva->polyphen_score; - my $pph_pred = $tva->polyphen_prediction; - my $sift_score = $tva->sift_score; - - my $results = {}; - - if (defined $pph_score && defined $sift_score && $pph_pred ne 'unknown') { - - my ($condel_pred, $condel_score) = $self->compute_condel($sift_score, $pph_score); - - $condel_score = sprintf "%.3f", $condel_score; - - my $output = "$condel_pred($condel_score)"; - - $output = $condel_pred if ($self->{output} =~ /^p/); - $output = $condel_score if ($self->{output} =~ /^s/); - - $results = { - Condel => $output, - }; - } - - return $results; -} - -sub compute_condel { - - my ($self, $sift_score, $polyphen_score) = @_; - - my $USE_V2 = $self->{version} == 2; - - my $class; - - my $base = 0; - my $int_score = 0; - - $sift_score = sprintf("%.3f", $sift_score); - $polyphen_score = sprintf("%.3f", $polyphen_score); - - if ($sift_score <= $self->{config}->{'cutoff.HumVar.sift'}){ - $int_score += sprintf("%.3f", (1 - $sift_score/$self->{config}->{'max.HumVar.sift'})*(1-$self->{sift}->{tn}->{$sift_score})); - $base += $USE_V2 ? 1 : 1-$self->{sift}->{tn}->{$sift_score}; - } - else { - $int_score += sprintf("%.3f", (1 - $sift_score/$self->{config}->{'max.HumVar.sift'})*(1-$self->{sift}->{tp}->{$sift_score})); - $base += $USE_V2 ? 1 : 1-$self->{sift}->{tp}->{$sift_score}; - } - - if ($polyphen_score >= $self->{config}->{'cutoff.HumVar.polyphen'}){ - $int_score += sprintf("%.3f", $polyphen_score/$self->{config}->{'max.HumVar.polyphen'}*(1-$self->{polyphen}->{tn}->{$polyphen_score})); - $base += $USE_V2 ? 1 : 1-$self->{polyphen}->{tn}->{$polyphen_score}; - } - else { - $int_score += sprintf("%.3f", $polyphen_score/$self->{config}->{'max.HumVar.polyphen'}*(1-$self->{polyphen}->{tp}->{$polyphen_score})); - $base += $USE_V2 ? 1 : 1-$self->{polyphen}->{tp}->{$polyphen_score}; - } - - if ($base == 0){ - $int_score = -1; - $class = 'not_computable_was'; - } - else { - $int_score = sprintf("%.3f", $int_score/$base); - } - - if ($int_score >= 0.469){ - $class = 'deleterious'; - } - elsif ($int_score >= 0 && $int_score < 0.469) { - $class = 'neutral'; - } - - # if the user wants an array, return the class and score, otherwise just return the class - - return ($class, $int_score); -} - -1;
--- a/dir_plugins/Conservation.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,222 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Conservation - -=head1 SYNOPSIS - - mv Conservation.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Conservation,GERP_CONSERVATION_SCORE,mammals - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - retrieves a conservation score from the Ensembl Compara databases - for variant positions. You can specify the method link type and - species sets as command line options, the default is to fetch GERP - scores from the EPO 35 way mammalian alignment (please refer to the - Compara documentation for more details of available analyses). - - If a variant affects multiple nucleotides the average score for the - position will be returned, and for insertions the average score of - the 2 flanking bases will be returned. - - The plugin requires the ensembl-compara API module to be installed; - see http://www.ensembl.org/info/docs/api/index.html - -=cut - -package Conservation; - -use strict; -use warnings; - -use Bio::EnsEMBL::Registry; -use Bio::EnsEMBL::Slice; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '2.3'; -} - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - - my $self = shift; - - return { - Conservation => "The conservation score for this site (method_link_type=\"". - $self->{method_link_type}."\", species_set=\"".$self->{species_set}."\")", - }; -} - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $params = $self->params; - - # REST API passes 1 as first param - shift @$params if $params->[0] && $params->[0] eq '1'; - - $self->{method_link_type} = $params->[0] || 'GERP_CONSERVATION_SCORE'; - $self->{species_set} = $params->[1] || 'mammals'; - - my $config = $self->{config}; - my $reg = 'Bio::EnsEMBL::Registry'; - - # reconnect to DB without species param - if($config->{host}) { - $reg->load_registry_from_db( - -host => $config->{host}, - -user => $config->{user}, - -pass => $config->{password}, - -port => $config->{port}, - -db_version => $config->{db_version}, - -no_cache => $config->{no_slice_cache}, - ); - } - - my $mlss_adap = $config->{mlssa} ||= $reg->get_adaptor('Multi', 'compara', 'MethodLinkSpeciesSet') - or die "Failed to connect to compara database\n"; - - $self->{mlss} = $mlss_adap->fetch_by_method_link_type_species_set_name($self->{method_link_type}, $self->{species_set}) - or die "Failed to fetch MLSS for ".$self->{method_link_type}." and ".$self->{species_set}."\n"; - - $self->{cs_adap} = $config->{cosa} ||= $reg->get_adaptor('Multi', 'compara', 'ConservationScore') - or die "Failed to fetch conservation adaptor\n"; - - return $self; -} - -sub run { - my ($self, $bvfoa) = @_; - - my $bvf = $bvfoa->base_variation_feature; - - # we cache the score on the BaseVariationFeature so we don't have to - # fetch it multiple times if this variant overlaps multiple Features - - unless (exists $bvf->{_conservation_score}) { - - my $slice; - - my $true_snp = 0; - - if ($bvf->{end} >= $bvf->{start}) { - - if ($bvf->{start} == $bvf->{end}) { - - # work around a bug in the compara API that means you can't fetch - # conservation scores for 1bp slices by creating a 2bp slice for - # SNPs and then ignoring the score returned for the second position - - my $s = $bvf->slice; - - $slice = Bio::EnsEMBL::Slice->new( - -seq_region_name => $s->seq_region_name, - -seq_region_length => $s->seq_region_length, - -coord_system => $s->coord_system, - -start => $bvf->{start}, - -end => $bvf->{end} + 1, - -strand => $bvf->{strand}, - -adaptor => $s->adaptor - ); - - $true_snp = 1; - } - else { - - # otherwise, just get a slice that covers our variant feature - - $slice = $bvf->feature_Slice; - } - } - else { - - # this is an insertion, we return the average score of the flanking - # bases, so we create a 2bp slice around the insertion site - - my $s = $bvf->slice; - - $slice = Bio::EnsEMBL::Slice->new( - -seq_region_name => $s->seq_region_name, - -seq_region_length => $s->seq_region_length, - -coord_system => $s->coord_system, - -start => $bvf->{end}, - -end => $bvf->{start}, - -strand => $bvf->{strand}, - -adaptor => $s->adaptor - ); - } - - my $scores = $self->{cs_adap}->fetch_all_by_MethodLinkSpeciesSet_Slice( - $self->{mlss}, # our MLSS for the conservation metric and the set of species - $slice, # our slice - ($slice->end - $slice->start + 1), # the number of scores we want back (one for each base) - ); - - if (@$scores > 0) { - - # we use the simple average of the diff_scores as the overall score - - pop @$scores if $true_snp; # get rid of our spurious second score for SNPs - - if (@$scores > 0) { - - my $tot_score = 0; - - $tot_score += $_->diff_score for @$scores; - - $tot_score /= @$scores; - - $bvf->{_conservation_score} = sprintf "%.3f", $tot_score; - } - else { - $bvf->{_conservation_score} = undef; - } - } - else { - $bvf->{_conservation_score} = undef; - } - } - - if (defined $bvf->{_conservation_score}) { - return { - Conservation => $bvf->{_conservation_score} - }; - } - else { - return {}; - } -} - -1; -
--- a/dir_plugins/DAS.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,127 +0,0 @@ -=head1 LICENSE - - Copyright (c) 1999-2015 The European Bioinformatics Institute and - Genome Research Limited. All rights reserved. - - This software is distributed under a modified Apache license. - For license details, please see - - http://www.ensembl.org/info/about/code_licence.html - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - DAS - -=head1 SYNOPSIS - - mv DAS.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin DAS,<DAS_server>,<DAS_source>,<proxy> - -=head1 DESCRIPTION - - A simple VEP plugin that checks for DAS features overlapping variants. Currently assumes that - the assemblies match, and doesn't do any smart fetching of chunks of features (i.e. the plugin - will query the DAS server once for every variant in the input file). - - You can run multiple instances of this plugin at the same time so you can query multiple DAS - servers and sources. If you are querying multiple sources from the same server it is - convenient to store the server name in an environment variable to avoid specifying it - multiple times, e.g.: - - export DAS="http://somewhere/das" - ./vep -i variations.vcf --plugin DAS,$DAS,source1 --plugin DAS,$DAS,source2 - - Requires the Bio::Das::Lite module from CPAN. - -=cut - -package DAS; - -use strict; -use warnings; - -use Bio::Das::Lite; -use Data::Dumper; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub get_header_info { - my $self = shift; - return { - $self->header => $self->{source}." features from DAS server ".$self->{server}, - }; -} - -sub feature_types { - return ['Transcript','RegulatoryFeature','MotifFeature','Intergenic']; -} - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my ($server, $source, $proxy) = @{ $self->params }; - - # strip off any trailing slash from the server URL - $server =~ s/\/$//; - - $self->{das} = Bio::Das::Lite->new({ - timeout => 10000, - dsn => "$server/$source", - http_proxy => $proxy, - }) || die "Failed to connect to DAS source: $server/$source"; - - $self->{source} = $source; - $self->{server} = $server; - - return $self; -} - -sub header { - my $self = shift; - return 'DAS_'.$self->{source}; -} - -sub run { - my ($self, $vfoa) = @_; - - my $vf = $vfoa->variation_feature; - - my $segment = $vf->seq_region_name .':'.$vf->seq_region_start.','.$vf->seq_region_end; - - # cache the results on the variation feature, making sure the cache key is unique given - # that there may be multiple DAS plugins running - - my $cache_key = '_vep_das_cache_'.$self->{server}.$self->{source}; - - unless (exists $vf->{$cache_key}->{$segment}) { - - $vf->{$cache_key}->{$segment} = []; - - if (my $response = $self->{das}->features($segment)) { - for my $url (keys %$response) { - if (ref $response->{$url} eq 'ARRAY') { - for my $feat (@{ $response->{$url} }) { - push @{ $vf->{$cache_key}->{$segment} }, $feat->{feature_label}.'('.$feat->{type}.')'; - } - } - } - } - } - - my $res = join ',', @{ $vf->{$cache_key}->{$segment} }; - - return $res ? {$self->header => $res} : {}; -} - -1; -
--- a/dir_plugins/Downstream.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,137 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Downstream - -=head1 SYNOPSIS - - mv Downstream.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Downstream - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - predicts the downstream effects of a frameshift variant on the protein - sequence of a transcript. It provides the predicted downstream protein - sequence (including any amino acids overlapped by the variant itself), - and the change in length relative to the reference protein. - - Note that changes in splicing are not predicted - only the existing - translateable (i.e. spliced) sequence is used as a source of - translation. Any variants with a splice site consequence type are - ignored. - -=cut - -package Downstream; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; -use POSIX qw(ceil); - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '2.3'; -} - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['VariationFeature']; -} - -sub get_header_info { - return { - DownstreamProtein => "Predicted downstream translation for frameshift mutations", - ProteinLengthChange => "Predicted change in protein product length", - }; -} - -sub run { - my ($self, $tva) = @_; - - my @ocs = @{$tva->get_all_OverlapConsequences}; - - if(grep {$_->SO_term eq 'frameshift_variant'} @ocs) { - - # can't do it for splice sites - return {} if grep {$_->SO_term =~ /splice/} @ocs; - - my $tv = $tva->transcript_variation; - my $tr = $tv->transcript; - my $cds_seq = defined($tr->{_variation_effect_feature_cache}) ? $tr->{_variation_effect_feature_cache}->{translateable_seq} : $tr->translateable_seq; - - # get the sequence to translate - my ($low_pos, $high_pos) = sort {$a <=> $b} ($tv->cds_start, $tv->cds_end); - my $is_insertion = $tv->cds_start > $tv->cds_end ? 1 : 0; - my $last_complete_codon = (ceil($low_pos / 3) - 1) * 3; - my $before_var_seq = substr $cds_seq, $last_complete_codon, $low_pos - $last_complete_codon - ($is_insertion ? 0 : 1); - my $after_var_seq = substr $cds_seq, $high_pos - ($is_insertion ? 1 : 0); - my $to_translate = $before_var_seq.$tva->feature_seq.$after_var_seq; - my $three_prime_utr_seq = $tr->three_prime_utr->seq() if ($tr->three_prime_utr); - $to_translate = $to_translate.$three_prime_utr_seq if ($three_prime_utr_seq); - $to_translate =~ s/\-//g; - - # create a bioperl object - my $codon_seq = Bio::Seq->new( - -seq => $to_translate, - -moltype => 'dna', - -alphabet => 'dna' - ); - - # get codon table - my $codon_table; - if(defined($tr->{_variation_effect_feature_cache})) { - $codon_table = $tr->{_variation_effect_feature_cache}->{codon_table} || 1; - } - else { - my ($attrib) = @{$tr->slice->get_all_Attributes('codon_table')}; - $codon_table = $attrib ? $attrib->value || 1 : 1; - } - - # translate - my $new_pep = $codon_seq->translate(undef, undef, undef, $codon_table)->seq(); - $new_pep =~ s/\*.*//; - - # compare lengths - my $translation = defined($tr->{_variation_effect_feature_cache}) && defined($tr->{_variation_effect_feature_cache}->{peptide}) ? $tr->{_variation_effect_feature_cache}->{peptide} : $tr->translation->seq; - my $new_length = ($tv->translation_start < $tv->translation_end ? $tv->translation_start : $tv->translation_end) + length($new_pep); - - return { - DownstreamProtein => $new_pep, - ProteinLengthChange => $new_length - length($translation), - }; - } - - return {}; -} - -1; -
--- a/dir_plugins/Draw.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,387 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Draw - -=head1 SYNOPSIS - - mv Draw.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Draw - -=head1 DESCRIPTION - - A VEP plugin that draws pictures of the transcript model showing the - variant location. Can take five optional paramters: - - 1) File name stem for images - 2) Image width in pixels (default: 1000px) - 3) Image height in pixels (default: 100px) - 4) Transcript ID - only draw images for this transcript - 5) Variant ID - only draw images for this variant - - e.g. - - ./vep -i variations.vcf --plugin Draw,myimg,2000,100 - - Images are written to [file_stem]_[transcript_id]_[variant_id].png - - Requires GD library installed to run. - -=cut - -package Draw; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -# GD libraries for image creating -use GD; -use GD::Polygon; - -use Bio::EnsEMBL::Variation::Utils::VariationEffect qw(MAX_DISTANCE_FROM_TRANSCRIPT); - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # configure - my @params = @{$self->params}; - - $self->{prefix} = $params[0] || $self->{config}->{output_file}; - $self->{width} = $params[1] || 1000; - $self->{height} = $params[2] || 100; - $self->{transcript} = $params[3] || undef; - $self->{variant} = $params[4] || undef; - - return $self; -} - -sub version { - return '2.4'; -} - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['BaseVariationFeature']; -} - -sub get_header_info { - return {}; -} - -sub run { - my ($self, $tva) = @_; - - my $main_tr = $tva->feature; - my $vf = $tva->base_variation_feature; - - return {} if defined($self->{transcript}) && $main_tr->stable_id ne $self->{transcript}; - return {} if defined($self->{variant}) && $vf->variation_name ne $self->{variant}; - - # if we're showing a gene fusion, get - my $second_tr = $tva->{_fusion_transcripts}->[0] if grep {$_->SO_term =~ /gene_fusion/} @{$tva->get_all_OverlapConsequences}; - - # set up scales etc - my $width = $main_tr->feature_Slice->length + (2 * MAX_DISTANCE_FROM_TRANSCRIPT); - my $tr_start = $main_tr->start - MAX_DISTANCE_FROM_TRANSCRIPT; - my $tr_end = $main_tr->end + MAX_DISTANCE_FROM_TRANSCRIPT; - - if(defined($second_tr)) { - $width = (max(($main_tr->end, $second_tr->end)) - min(($main_tr->start, $second_tr->start))) + 1 + (2 * MAX_DISTANCE_FROM_TRANSCRIPT); - $tr_start = min(($main_tr->start, $second_tr->start)) - MAX_DISTANCE_FROM_TRANSCRIPT; - $tr_end = max(($main_tr->end, $second_tr->end)) + MAX_DISTANCE_FROM_TRANSCRIPT; - } - - my $x_scale = ($self->{width} - 20) / $width; - my $y_scale = ($self->{height} - 30) / 100; - my $x_off = 10; - my $y_off = 20; - - # create GD image object - my $img = GD::Image->new($self->{width}, $self->{height}); - - # set up some colours - my %colours = ( - white => $img->colorAllocate(255,255,255), - black => $img->colorAllocate(0,0,0), - grey => $img->colorAllocate(200,200,200), - darkgrey => $img->colorAllocate(150,150,150), - vlightgrey => $img->colorAllocate(235,235,235), - blue => $img->colorAllocate(0,0,200), - lightblue => $img->colorAllocate(200,200,255), - red => $img->colorAllocate(200,0,0), - lightred => $img->colorAllocate(255,200,200), - green => $img->colorAllocate(0,200,0), - lightgreen => $img->colorAllocate(220,255,220), - yellow => $img->colorAllocate(236,164,26), - purple => $img->colorAllocate(195,50,212), - ); - - # scale bar - my $zero_string = '0' x (length(int(100 / $x_scale)) - 1); - my $bases_per_bar = '1'.$zero_string; - - my $start = int($tr_start / $bases_per_bar) * $bases_per_bar; - my $end = (int($tr_start / $bases_per_bar) + 1) * $bases_per_bar; - my $colour = 0; - - while($start < $tr_end) { - my $method = $colour ? 'rectangle' : 'filledRectangle'; - - $img->$method( - $x_off + (($start - $tr_start) * $x_scale), - $self->{height} - 15, - $x_off + (($end - $tr_start) * $x_scale), - $self->{height} - 10, - $colours{grey}, - ); - - # tick and label - if($start =~ /(5|0)$zero_string$/) { - my $string = $start; - 1 while $string =~ s/^(-?\d+)(\d\d\d)/$1,$2/; - - $img->string( - gdTinyFont, - $x_off + (($start - $tr_start) * $x_scale) + 2, - $self->{height} - 8, - $string, - $colours{black} - ); - - $img->line( - $x_off + (($start - $tr_start) * $x_scale), - $self->{height} - 15, - $x_off + (($start - $tr_start) * $x_scale), - $self->{height}, - $start =~ /5$zero_string$/ ? $colours{grey} : $colours{black} - ); - - $img->dashedLine( - $x_off + (($start - $tr_start) * $x_scale), - 0, - $x_off + (($start - $tr_start) * $x_scale), - $self->{height} - 15, - $start =~ /5$zero_string$/ ? $colours{vlightgrey} : $colours{grey} - ) - } - - $colour = 1 - $colour; - $start += $bases_per_bar; - $end += $bases_per_bar; - } - - # render transcripts - foreach my $tr($main_tr, $second_tr) { - next unless defined($tr); - - # render introns - foreach my $intron(@{$tr->get_all_Introns}) { - $img->line( - $x_off + (($intron->start - $tr_start) * $x_scale), - $y_off + (20 * $y_scale), - $x_off + (((($intron->start + $intron->end) / 2) - $tr_start) * $x_scale), - $y_off + (10 * $y_scale), - $colours{lightblue} - ); - - $img->line( - $x_off + (((($intron->start + $intron->end) / 2) - $tr_start) * $x_scale), - $y_off + (10 * $y_scale), - $x_off + (($intron->end - $tr_start) * $x_scale), - $y_off + (20 * $y_scale), - $colours{lightblue} - ); - } - - # render exons - foreach my $exon(@{$tr->get_all_Exons}) { - - # non-coding part - $img->rectangle( - $x_off + (($exon->start - $tr_start) * $x_scale), - $y_off + (10 * $y_scale), - $x_off + (($exon->end - $tr_start) * $x_scale), - $y_off + (30 * $y_scale), - $colours{lightblue} - ); - - # coding part - $img->filledRectangle( - $x_off + (($exon->coding_region_start($tr) - $tr_start) * $x_scale), - $y_off + (0 * $y_scale), - $x_off + (($exon->coding_region_end($tr) - $tr_start) * $x_scale), - $y_off + (40 * $y_scale), - $colours{blue} - ) if defined $exon->coding_region_start($tr) && defined $exon->coding_region_end($tr); - } - - # add transcript direction indicator - if($tr->strand == 1) { - - # vertical line - $img->line( - $x_off + (($tr->start - $tr_start) * $x_scale), - $y_off + (-5 * $y_scale), - $x_off + (($tr->start - $tr_start) * $x_scale), - $y_off + (20 * $y_scale), - $colours{lightblue}, - ); - - # horizontal line - $img->line( - $x_off + (($tr->start - $tr_start) * $x_scale), - $y_off + (-5 * $y_scale), - $x_off + (($tr->start - $tr_start) * $x_scale) + 20, - $y_off + (-5 * $y_scale), - $colours{lightblue}, - ); - - # top arrow part - $img->line( - $x_off + (($tr->start - $tr_start) * $x_scale) + 17, - $y_off + (-8 * $y_scale), - $x_off + (($tr->start - $tr_start) * $x_scale) + 20, - $y_off + (-5 * $y_scale), - $colours{lightblue}, - ); - - # bottom arrow part - $img->line( - $x_off + (($tr->start - $tr_start) * $x_scale) + 17, - $y_off + (-1 * $y_scale), - $x_off + (($tr->start - $tr_start) * $x_scale) + 20, - $y_off + (-5 * $y_scale), - $colours{lightblue}, - ); - - # label - $img->string(gdTinyFont, $x_off + (($tr->start - $tr_start) * $x_scale) + 25, $y_off + (-12 * $y_scale), $tr->stable_id, $colours{blue}); - } - - else { - - # vertical line - $img->line( - $x_off + (($tr->end - $tr_start) * $x_scale), - $y_off + (20 * $y_scale), - $x_off + (($tr->end - $tr_start) * $x_scale), - $y_off + (47 * $y_scale), - $colours{lightblue}, - ); - - # horizontal line - $img->line( - $x_off + (($tr->end - $tr_start) * $x_scale), - $y_off + (47 * $y_scale), - $x_off + (($tr->end - $tr_start) * $x_scale) - 20, - $y_off + (47 * $y_scale), - $colours{lightblue}, - ); - - # top arrow part - $img->line( - $x_off + (($tr->end - $tr_start) * $x_scale) - 17, - $y_off + (50 * $y_scale), - $x_off + (($tr->end - $tr_start) * $x_scale) - 20, - $y_off + (47 * $y_scale), - $colours{lightblue}, - ); - - # bottom arrow part - $img->line( - $x_off + (($tr->end - $tr_start) * $x_scale) - 17, - $y_off + (43 * $y_scale), - $x_off + (($tr->end - $tr_start) * $x_scale) - 20, - $y_off + (47 * $y_scale), - $colours{lightblue}, - ); - - # label - $img->string(gdTinyFont, $x_off + (($tr->end - $tr_start) * $x_scale) - 100, $y_off + (43 * $y_scale), $tr->stable_id, $colours{blue}); - } - } - - # render variant - my $var_colour = 'green'; - - if($vf->class_SO_term =~ /deletion/) { - $var_colour = 'red'; - } - - $img->filledRectangle( - $x_off + (($vf->start - $tr_start) * $x_scale), - $y_off + (60 * $y_scale), - $x_off + (($vf->end - $tr_start) * $x_scale), - $y_off + (70 * $y_scale), - $colours{$var_colour}, - ); - - # variant label - $img->string( - gdTinyFont, - $x_off + (($vf->start - $tr_start) * $x_scale), - $y_off + (75 * $y_scale), - $vf->variation_name, - $colours{$var_colour} - ); - - my $vname = $vf->variation_name; - $vname =~ s/\//\_/g; - my $file = $self->{prefix}."_".$main_tr->stable_id."_".(defined($second_tr) ? $second_tr->stable_id."_" : "").$vname."\.png"; - - # check we're allowed to write to it - if(!defined($self->{config}->{force_overwrite}) && -e $file) { - die "ERROR: Image file $file already exists - choose a different file name stem or use --force_overwrite\n"; - return; - } - - open IM, ">$file" or die "ERROR: Could not write to file $file\n"; - binmode IM; - print IM $img->png; - close IM; - - return {}; -} - -sub max { - return (sort {$a <=> $b} @_)[-1]; -} - -sub min { - return (sort {$a <=> $b} @_)[0]; -} - -1; -
--- a/dir_plugins/ExAC.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,293 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - ExAC - -=head1 SYNOPSIS - - mv ExAC.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin ExAC,/path/to/ExAC/ExAC.r0.3.sites.vep.vcf.gz - ./vep -i variations.vcf --plugin ExAC,/path/to/ExAC/ExAC.r0.3.sites.vep.vcf.gz,AC - ./vep -i variations.vcf --plugin ExAC,/path/to/ExAC/ExAC.r0.3.sites.vep.vcf.gz,,AN - ./vep -i variations.vcf --plugin ExAC,/path/to/ExAC/ExAC.r0.3.sites.vep.vcf.gz,AC,AN - - - -=head1 DESCRIPTION - - A VEP plugin that retrieves ExAC allele frequencies. - - Visit ftp://ftp.broadinstitute.org/pub/ExAC_release/current to download the latest ExAC VCF. - - Note that the currently available version of the ExAC data file (0.3) is only available - on the GRCh37 assembly; therefore it can only be used with this plugin when using the - VEP on GRCh37. See http://www.ensembl.org/info/docs/tools/vep/script/vep_other.html#assembly - - The tabix utility must be installed in your path to use this plugin. - - The plugin takes 3 command line arguments. Second and third arguments are not mandatory. If AC specified as second - argument Allele counts per population will be included in output. If AN specified as third argument Allele specific - chromosome counts will be included in output. - - -=cut - -package ExAC; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); -use Bio::EnsEMBL::Variation::Utils::Sequence qw(get_matched_variant_alleles); - -use Bio::EnsEMBL::Variation::Utils::VEP qw(parse_line get_slice); - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # test tabix - die "ERROR: tabix does not seem to be in your path\n" unless `which tabix 2>&1` =~ /tabix$/; - - # get ExAC file - my $file = $self->params->[0]; - - # get AC,AN options - if (exists($self->params->[1]) && $self->params->[1] eq 'AC'){ - $self->{display_ac} = 1; - } - else { - $self->{display_ac} = 0; - } - - if (exists($self->params->[2]) && $self->params->[2] eq 'AN'){ - $self->{display_an} = 1; - } - else { - $self->{display_an} = 0; - } - - # remote files? - if($file =~ /tp\:\/\//) { - my $remote_test = `tabix -f $file 1:1-1 2>&1`; - print STDERR "$remote_test\n"; - # if($remote_test && $remote_test !~ /get_local_version/) { - # die "$remote_test\nERROR: Could not find file or index file for remote annotation file $file\n"; - # } - } - - # check files exist - else { - die "ERROR: ExAC file $file not found; you can download it from ftp://ftp.broadinstitute.org/pub/ExAC_release/current\n" unless -e $file; - die "ERROR: Tabix index file $file\.tbi not found - perhaps you need to create it first?\n" unless -e $file.'.tbi'; - } - - $self->{file} = $file; - - return $self; -} - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - my $self = shift; - - if(!exists($self->{header_info})) { - open IN, "tabix -f -h ".$self->{file}." 1:1-1 |"; - - my %headers = (); - my @lines = <IN>; - - while(my $line = shift @lines) { - if($line =~ /ID\=AC(\_[A-Zdj]+)?\,.*\"(.+)\"/) { - my ($pop, $desc) = ($1, $2); - - $desc =~ s/Counts?/frequency/i; - $pop ||= ''; - - my $field_name = 'ExAC_AF'.$pop; - $headers{$field_name} = 'ExAC '.$desc; - - if ($self->{display_ac}){ - $field_name = 'ExAC_AC'.$pop; - $headers{$field_name} = 'ExAC'.$pop.' Allele count'; - } - if ($self->{display_an}){ - $field_name = 'ExAC_AN'.$pop; - $headers{$field_name} = 'ExAC'.$pop.' Allele number'; - } - - # store this header on self - push @{$self->{headers}}, 'AC'.$pop; - } - } - - close IN; - - die "ERROR: No valid headers found in ExAC VCF file\n" unless scalar keys %headers; - - $self->{header_info} = \%headers; - } - - return $self->{header_info}; -} - -sub run { - my ($self, $tva) = @_; - # make sure headers have been loaded - $self->get_header_info(); - - my $vf = $tva->variation_feature; - my $name = $vf->variation_name; - - # get allele, reverse comp if needed - my $allele; - - $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - # adjust coords to account for VCF-like storage of indels - my ($s, $e) = ($vf->{start} - 1, $vf->{end} + 1); - - my $vf_chr = $vf->{chr}; - $vf_chr =~ s/chr//; - my $pos_string = sprintf("%s:%i-%i", $vf_chr, $s, $e); - - - # clear cache if it looks like the coords are the same - # but allele type is different - delete $self->{cache} if - defined($self->{cache}->{$pos_string}) && - scalar keys %{$self->{cache}->{$pos_string}} && - !defined($self->{cache}->{$pos_string}->{$allele}); - - my $data = {}; - - # cached? - if(defined($self->{cache}) && defined($self->{cache}->{$pos_string})) { - $data = $self->{cache}->{$pos_string}; - } - - # read from file - else { - open TABIX, sprintf("tabix -f %s %s |", $self->{file}, $pos_string); - - while(<TABIX>) { - chomp; - s/\r$//g; - # parse VCF line into a VariationFeature object - my ($vcf_vf) = @{parse_line({format => 'vcf', minimal => 1}, $_)}; - - # check parsed OK - next unless $vcf_vf && $vcf_vf->isa('Bio::EnsEMBL::Variation::VariationFeature'); - - my @vcf_alleles = split /\//, $vcf_vf->allele_string; - my $ref_allele = shift @vcf_alleles; - my $vcf_vf_start = $vcf_vf->{start}; - my $vcf_vf_end = $vcf_vf->{end}; - - my @vf_alleles = split /\//, $vf->allele_string; - my $vf_ref_allele = shift @vf_alleles; - - if ($vcf_vf_start != $vf->{start} || $vcf_vf_end != $vf->{end}) { - my $matched_alleles = get_matched_variant_alleles({ref => $vf_ref_allele, alts => [$allele], pos => $vf->{start}}, {ref => $ref_allele, alts => \@vcf_alleles, pos => $vcf_vf_start}); - - next unless (@$matched_alleles); - # We only match one alt allele from the input VF against alleles from the VCF line. b_allele is the matched allele from the VCF alt alleles - $allele = $matched_alleles->[0]->{b_allele}; - } - # iterate over required headers - HEADER: - foreach my $h(@{$self->{headers} || []}) { - my $total_ac = 0; - - if(/$h\=([0-9\,]+)/) { - - # grab AC - my @ac = split /\,/, $1; - next unless scalar @ac == scalar @vcf_alleles; - - # now sed header to get AN - my $anh = $h; - $anh =~ s/AC/AN/; - - my $afh = $h; - $afh =~ s/AC/AF/; - - # get AC from header - my $ach = $h; - - if(/$anh\=([0-9\,]+)/) { - - # grab AN - my @an = split /\,/, $1; - next unless @an; - my $an; - - foreach my $a(@vcf_alleles) { - my $ac = shift @ac; - $an = shift @an if @an; - - $total_ac += $ac; - if ($self->{display_ac}){ - $data->{$a}->{'ExAC_'.$ach} = $ac; - } - if ($self->{display_an}){ - $data->{$a}->{'ExAC_'.$anh} = $an; - } - - $data->{$a}->{'ExAC_'.$afh} = sprintf("%.3g", $ac / $an) if $an; - } - - # use total to get ref allele freq - if ($self->{display_ac}){ - $data->{$ref_allele}->{'ExAC_'.$ach} = $total_ac; - } - if ($self->{display_an}){ - $data->{$ref_allele}->{'ExAC_'.$anh} = $an; - } - $data->{$ref_allele}->{'ExAC_'.$afh} = sprintf("%.3g", 1 - ($total_ac / $an)) if $an; - } - } - } - } - - close TABIX; - } - - # overwrite cache - $self->{cache} = {$pos_string => $data}; - return defined($data->{$allele}) ? $data->{$allele} : {}; -} - -1; -
--- a/dir_plugins/ExACpLI.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,134 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Please email comments or questions to the public Ensembl - developers list at <http://lists.ensembl.org/mailman/listinfo/dev>. - - Questions may also be sent to the Ensembl help desk at - <http://www.ensembl.org/Help/Contact>. - -=cut - -=head1 NAME - -ExACpLI - Add ExAC pLI to the VEP output - -=head1 SYNOPSIS - - mv ExACpLI.pm ~/.vep/Plugins - mv ExACpLI_values.txt ~/.vep/Plugins - ./vep -i variants.vcf --plugin ExACpLI - -=head1 DESCRIPTION - - - A VEP plugin that adds the probabililty of a gene being - loss-of-function intolerant (pLI) to the VEP output. - - Lek et al. (2016) estimated pLI using the expectation-maximization - (EM) algorithm and data from 60,706 individuals from - ExAC (http://exac.broadinstitute.org/about). The closer pLI is to 1, - the more likely the gene is loss-of-function (LoF) intolerant. - - Note: the pLI was calculated using a representative transcript and - is reported by gene in the plugin. - - The data for the plugin is provided by Kaitlin Samocha and Daniel MacArthur. - See https://www.ncbi.nlm.nih.gov/pubmed/27535533 for a description - of the dataset and analysis. - - The ExACpLI_values.txt file is found alongside the plugin in the - VEP_plugins GitHub repository. The file contains the fields gene and pLI - extracted from the file at - - ftp://ftp.broadinstitute.org/pub/ExAC_release/release0.3/functional_gene_constraint/ - fordist_cleaned_exac_r03_march16_z_pli_rec_null_data.txt - - To use another values file, add it as a parameter i.e. - - ./vep -i variants.vcf --plugin ExACpLI,values_file.txt - - -=cut - -package ExACpLI; - -use strict; -use warnings; - -use DBI; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $file = $self->params->[0]; - - if(!$file) { - my $plugin_dir = $INC{'ExACpLI.pm'}; - $plugin_dir =~ s/ExACpLI\.pm//i; - $file = $plugin_dir.'/ExACpLI_values.txt'; - } - - die("ERROR: ExACpLI values file $file not found\n") unless $file && -e $file; - - open my $fh, "<", $file; - my %scores; - - while(<$fh>) { - chomp; - my ($gene, $score) = split; - next if $score eq 'pLI'; - $scores{lc($gene)} = sprintf("%.2f", $score); - } - - close $fh; - - die("ERROR: No scores read from $file\n") unless scalar keys %scores; - - $self->{scores} = \%scores; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - ExACpLI => "ExACpLI value for gene" - }; -} - -sub run { - my $self = shift; - my $tva = shift; - - my $symbol = $tva->transcript->{_gene_symbol} || $tva->transcript->{_gene_hgnc}; - return {} unless $symbol; - - return $self->{scores}->{lc($symbol)} ? { ExACpLI => $self->{scores}->{lc($symbol)}} : {}; -} - -1; -
--- a/dir_plugins/ExACpLI_values.txt Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,18226 +0,0 @@ -gene pLI -AGRN 0.17335234048116 -NOC2L 1.33038194561114e-19 -B3GALT6 0.0481044658297901 -C1orf159 0.0908776364218918 -ISG15 0.00984781293610986 -KLHL17 2.51676266070248e-07 -PLEKHN1 2.01974835522321e-08 -SAMD11 1.35381157129201e-10 -OR4F5 0.176329298172162 -HES4 0.00014794288110518 -FAM132A 4.67625423888147e-05 -TNFRSF18 8.36589277636991e-07 -SDF4 0.0013098271899439 -TNFRSF4 0.00720932981621916 -TTLL10 1.94738806982348e-05 -UBE2J2 0.415938846926224 -ATAD3C 4.90849565539176e-05 -MRPL20 0.000171803357075406 -CPSF3L 5.7881402380741e-09 -AURKAIP1 0.00247538764889321 -SSU72 0.606848849205337 -GLTPD1 0.00138279022732508 -MXRA8 0.00471297228153819 -ACAP3 0.0394309302206711 -VWA1 0.0331997601703093 -ATAD3A 0.0401305978810457 -CCNL2 0.104548195351159 -DVL1 0.157164971605877 -SCNN1D 2.82187066585139e-15 -ATAD3B 1.92301228016303e-13 -PUSL1 6.58681964674524e-12 -C1orf86 0.785170903024389 -SKI 0.981402099833324 -CDK11B 0.72829443952872 -GNB1 0.995187833121982 -SLC35E2B 0.62100245921917 -CDK11A 5.23535259576534e-05 -NADK 0.00126768961404905 -PEX10 0.010463632475946 -CALML6 0.000127436926421093 -TMEM52 0.328693114330909 -MORN1 7.87931445985798e-07 -GABRD 0.923498878454823 -PRKCZ 0.266923656763182 -RER1 0.969239732851388 -MIB2 0.000158543294053226 -SLC35E2 0.374305907762633 -PRDM16 0.999843194473124 -TP73 0.975977778366269 -PLCH2 1.70518647543863e-08 -LRRC47 0.60383218752352 -DFFB 5.08618071063922e-05 -ACTRT2 0.0187224605335923 -ARHGEF16 9.36505312388017e-08 -TPRG1L 0.00284528475212618 -HES5 0.532717161921776 -C1orf174 0.0187425021060312 -MEGF6 4.42421031130217e-15 -FAM213B 0.000166699570192146 -CCDC27 1.60569656764963e-19 -WRAP73 0.0269219902261615 -CEP104 2.63081806867216e-08 -MMEL1 8.87673673427084e-13 -PANK4 0.945333401831958 -TNFRSF14 0.819999054408814 -KLHL21 0.00107735176759231 -NOL9 0.0044702400177699 -PLEKHG5 4.02821229083025e-05 -KCNAB2 0.839972632374732 -ICMT 0.95914542813838 -ESPN 0.00255384128821556 -AJAP1 0.977592766896285 -ZBTB48 0.680198376469515 -TNFRSF25 0.448738853101197 -TAS1R1 7.9136002871651e-09 -NPHP4 1.29374352876183e-17 -RPL22 0.348492156430072 -RNF207 5.19011202351337e-06 -HES3 0.268868568223653 -CHD5 0.999999995117076 -PHF13 0.931111283002542 -THAP3 0.00148422474585026 -ACOT7 0.381517901841213 -HES2 0.0670466550651167 -GPR153 0.000377954117161823 -VAMP3 0.0542630674689049 -SLC45A1 0.0451892558909179 -CA6 0.00802362076493995 -DNAJC11 0.999970790294974 -PIK3CD 0.999984294919708 -ENO1 0.0103734127326719 -SLC25A33 0.451158319130907 -ERRFI1 0.046551582399882 -SLC2A5 5.67732629021242e-05 -GPR157 2.63491769393547e-05 -UTS2 0.151041459001058 -SLC2A7 2.99498303352468e-17 -TMEM201 0.841903867149445 -TNFRSF9 0.253050500972917 -CAMTA1 0.999999955418418 -PARK7 0.903949397411231 -PER3 2.19067741322434e-10 -H6PD 0.000111404418020294 -SPSB1 0.709596082305861 -RERE 0.999995655258253 -PEX14 0.634568377657546 -CLSTN1 0.844214450133216 -APITD1-CORT 0.00852090111528864 -DFFA 0.00021837065189826 -TARDBP 0.980707836590808 -EXOSC10 1.65795367368417e-07 -LZIC 0.00197924734359642 -CORT 0.0098377909618654 -SRM 0.869848472217591 -PGD 0.968660462332331 -RBP7 0.408810205691644 -CTNNBIP1 0.0229867402741806 -C1orf200 0.0549230054401102 -CASZ1 0.999938476327784 -KIF1B 0.999999999958917 -MASP2 1.58468707892368e-14 -UBE4B 0.999987413556799 -C1orf127 1.33454849505904e-05 -APITD1 0.00852090111528864 -NMNAT1 0.22529193858776 -FBXO6 0.00048573148176465 -FBXO2 0.273382985936642 -FBXO44 3.59578966017025e-05 -NPPB 0.00038006045771278 -MAD2L2 0.202505866427509 -UBIAD1 0.568905634331064 -MIIP 1.96191775619765e-15 -MFN2 0.999816094005639 -C1orf167 0.155526802173754 -CLCN6 0.163974191293187 -TNFRSF8 0.845965386736897 -PLOD1 2.70207303676794e-07 -MTOR 0.999999999999676 -DRAXIN 6.64368474068458e-10 -ANGPTL7 8.44492793664119e-09 -MTHFR 2.45515809266206e-07 -NPPA 0.0169316348826086 -AGTRAP 0.0416634032877011 -PTCHD2 4.16505137948208e-05 -AADACL3 0.00015633351437561 -PRAMEF6 0.691325858232332 -PRAMEF1 0.0981051636001553 -PRAMEF12 3.89692512946575e-06 -HNRNPCL1 0.0107232661654143 -TNFRSF1B 0.778880984183769 -DHRS3 0.661359704005279 -PRAMEF2 0.000567609686510291 -C1orf158 1.57145922132303e-08 -PRAMEF22 0.617146896404532 -PRAMEF11 0.285437974687136 -PRAMEF4 0.0746095246056682 -AADACL4 0.000547686324044419 -PRAMEF10 0.875594718751663 -VPS13D 0.999992132395372 -PRAMEF7 0.17686296313217 -PRAMEF14 0.55964161278638 -PRDM2 0.995040619056877 -TMEM51 0.870759443080077 -PRAMEF19 0.583094142263464 -PDPN 0.000983708235301868 -CELA2B 0.000617208883252854 -CTRC 5.21992306515278e-06 -EFHD2 0.378995543892118 -PRAMEF17 0.790929575854879 -PRAMEF13 0.529422081197501 -CELA2A 1.98449208206109e-06 -KAZN 0.144589791042949 -AGMAT 0.00367262488905154 -SPEN 0.999999999999963 -TMEM82 1.22973402675374e-05 -SLC25A34 0.000948152762042176 -FBLIM1 0.000789060297699282 -PLEKHM2 0.00506557458482561 -CLCNKA 2.74927659103062e-14 -DNAJC16 3.79285066744292e-05 -RSG1 1.08197156167219e-06 -ARHGEF19 7.63919108459289e-09 -FAM131C 0.276924372627756 -EPHA2 0.738294173427745 -HSPB7 0.013149236960213 -CLCNKB 7.80835912699469e-12 -ZBTB17 0.998165364992239 -DDI2 0.941088127387327 -RSC1A1 1.4572097447573e-08 -C1orf64 0.0105592094696203 -CASP9 0.00319395567190647 -FBXO42 0.975946026927229 -PADI1 5.26823569922429e-11 -CROCC 4.70612895871808e-20 -ATP13A2 0.00120495054739301 -ARHGEF10L 0.0383062935578488 -PADI2 0.000124031218347057 -PADI4 1.30424837822011e-09 -SDHB 0.0501027715702188 -NECAP2 6.86667313977443e-05 -MFAP2 0.000124328486872189 -SPATA21 3.58477021907411e-06 -RCC2 0.787633127226415 -SZRD1 0.719865991219815 -IGSF21 0.547298802614659 -PADI3 4.68791671509589e-10 -ACTL8 0.077144245715306 -UBR4 1 -KLHDC7A 2.58274593353359e-10 -CAPZB 0.592160351133202 -AKR7A3 6.13891503863645e-10 -TMCO4 9.98392215947084e-13 -NBL1 0.108864872574092 -ALDH4A1 0.000434043544234141 -EMC1 6.03747917977484e-14 -PAX7 0.629829299867052 -HTR6 0.00106725360649504 -AKR7L 0.00438244228415804 -TAS1R2 6.17507053671979e-13 -PQLC2 0.000146809008866195 -OTUD3 2.62536799027489e-05 -MINOS1 0.348880394858809 -IFFO2 0.382583916452741 -AKR7A2 3.55874178311221e-06 -MINOS1-NBL1 0.0681079828537187 -RNF186 0.0154783237731939 -MRTO4 0.869977920352301 -NBPF3 1.98380335692613e-11 -PINK1 4.0835436809341e-07 -DDOST 0.134980573644975 -EIF4G3 0.999999906532496 -CDA 0.787227682049009 -PLA2G5 0.000190274829493542 -ECE1 0.999768645958376 -CAMK2N1 0.138563181790624 -PLA2G2F 2.09867850599463e-06 -MUL1 3.48969973575906e-06 -SH2D5 0.00265361571731959 -KIF17 3.34364105878855e-13 -PLA2G2A 0.398124558137518 -PLA2G2D 0.000177682796600803 -PLA2G2C 0.000569562808573398 -PLA2G2E 0.000343166465007747 -UBXN10 0.000293934797697053 -HP1BP3 0.991643467677446 -RAP1GAP 0.974156915163255 -EPHA8 1.13671356316739e-08 -C1QB 0.0858810485832231 -ZBTB40 1.21207769768767e-05 -C1QC 0.0173819025149602 -LUZP1 0.287846256098982 -CELA3A 9.82224694641128e-08 -EPHB2 0.999948635231362 -LDLRAD2 0.000195122663626231 -ALPL 0.00110649599056032 -CDC42 0.656574472233884 -C1QA 0.0497899792321254 -WNT4 0.153837855740478 -CELA3B 2.11744211573648e-10 -USP48 0.999997429389181 -HTR1D 0.813006424567561 -HSPG2 6.94653656591348e-06 -KDM1A 0.991027964686515 -MDS2 0.0429655728784688 -HNRNPR 0.999079074304417 -RPL11 0.725843320629066 -ZNF436 0.304488387158864 -IL22RA1 0.0644008505714252 -TCEB3 0.999991942292927 -C1orf213 0.000260771141851481 -LYPLA2 0.979519145027567 -FUCA1 3.3905830953051e-08 -TCEA3 0.000965885853095805 -GALE 3.26698555553297e-08 -E2F2 0.914702778499156 -HMGCL 0.00256252926835471 -PITHD1 0.102416722752494 -ID3 0.68879433753555 -MYOM3 9.28408886540307e-28 -CNR2 0.00011072577844674 -ASAP3 2.35907220968951e-10 -TMEM50A 0.333486481175581 -C1orf63 2.72287500037132e-08 -RCAN3 0.00320642195331169 -MAN1C1 0.0490480402547963 -MTFR1L 0.431750877541367 -IFNLR1 0.308615221609601 -RHD 0.00606009991775824 -TMEM57 0.992504411290221 -SYF2 0.0379270965280319 -RUNX3 0.673967691642928 -CLIC4 0.00946200366501209 -RHCE 0.861454126246099 -NIPAL3 0.000454711893618813 -NCMAP 0.0672670336239585 -GRHL3 0.99558395801223 -LDLRAP1 2.90076895064709e-05 -SRRM1 0.999999022390233 -STPG1 0.00010643410734956 -SEPN1 1.08497392205754e-07 -UBXN11 1.20340272757806e-10 -LIN28A 0.196269887367842 -CATSPER4 3.16436332178783e-05 -FAM110D 0.550404227081523 -AUNIP 5.49329871865606e-08 -CNKSR1 3.79048704121579e-16 -ZNF683 0.00156069704939338 -CEP85 0.00585126875456993 -PAFAH2 2.68539651867445e-07 -PDIK1L 0.381253877249055 -DHDDS 0.704700922518414 -AIM1L 3.33461351873646e-07 -STMN1 0.648591503545553 -SLC30A2 0.708283236156756 -SH3BGRL3 0.795103829065415 -ZNF593 0.156440973665101 -TRIM63 4.71828632864004e-12 -EXTL1 1.17897567862766e-12 -PAQR7 0.0093107679780527 -CD52 0.530686211965741 -FCN3 0.0172513382815348 -WDTC1 0.99930782583365 -PIGV 7.2042376998992e-06 -ARID1A 0.999999996642687 -HMGN2 0.79667455877069 -TMEM222 0.0719860750297163 -SFN 0.490890062387915 -CD164L2 0.0337448656970662 -MAP3K6 4.90980509511437e-15 -GPATCH3 6.05252012288109e-07 -RPS6KA1 0.725875552839744 -SYTL1 1.0822256796955e-07 -ZDHHC18 0.00119784993745536 -NUDC 0.822775133437605 -GPN2 0.0369234540989058 -FAM46B 0.0511898745130631 -NR0B2 5.83479715619009e-08 -SLC9A1 0.952228129998873 -C1orf172 0.153805473990332 -XKR8 1.43123535164264e-05 -STX12 0.896720265506838 -EYA3 0.995035731060423 -PPP1R8 0.954054369869303 -FGR 0.177174438745081 -IFI6 0.230931224633812 -SESN2 0.00076370931416015 -FAM76A 0.000561029444884688 -ATPIF1 0.0593535041039216 -AHDC1 0.999431447817631 -MED18 0.000448333946024653 -PTAFR 0.118775353428594 -GPR3 0.0209357972702136 -THEMIS2 0.0647217124407372 -WASF2 0.975317445622322 -SMPDL3B 1.39140296501713e-07 -DNAJC8 0.582006641588927 -RPA2 0.888461678653319 -SRSF4 0.934762697175769 -OPRD1 0.109062189113339 -SNRNP40 0.825363235899783 -PHACTR4 0.00427377620221426 -TAF12 0.892665247929895 -SDC3 0.527916180650144 -LAPTM5 0.735702166051801 -RCC1 0.19394393095681 -PUM1 0.999998854510137 -PTPRU 0.990698955783316 -ZCCHC17 0.215147590312843 -GMEB1 0.960593932192331 -TMEM200B 0.15528270100677 -EPB41 0.0621098709716946 -RAB42 0.00255498366167514 -TRNAU1AP 0.882819951620334 -MATN1 0.00527398583990045 -NKAIN1 0.615737172831643 -YTHDF2 0.99116572766449 -MECR 0.0036031322030062 -FABP3 0.354913336595959 -EIF3I 0.417329824985689 -COL16A1 3.38473511158888e-15 -CCDC28B 9.96843350374975e-08 -PEF1 0.323496548949568 -BAI2 0.995235377472474 -SERINC2 1.03374403745308e-06 -KPNA6 0.988827605869537 -AC114494.1 0.0296791583668939 -PTP4A2 0.760772901354061 -SPOCD1 8.79900241092214e-06 -TXLNA 0.995925358284739 -HCRTR1 0.261800018351598 -IQCC 2.25735733275782e-07 -TMEM234 0.000523997901712417 -DCDC2B 8.88085255997303e-08 -TINAGL1 0.245105548080211 -KHDRBS1 0.94687645920226 -TMEM39B 0.021450432147613 -BSDC1 0.482345221176286 -TMEM54 0.164454120579217 -TSSK3 0.763235263396559 -FAM167B 0.00269115267024858 -ZBTB8B 0.360954124529864 -HPCA 0.433846185685315 -MARCKSL1 0.653774932497598 -KIAA1522 0.802365146971355 -ZBTB8A 0.106372648345456 -ZBTB8OS 0.95574935791171 -FNDC5 0.406509132252723 -HDAC1 0.937916989643132 -SYNC 0.0416853059014448 -RNF19B 0.625353364992841 -RBBP4 0.989804589203081 -YARS 0.000308553759899848 -LCK 0.999425040716645 -S100PBP 0.947039388875535 -PHC2 0.205656047583874 -TRIM62 0.00161141831959926 -SFPQ 0.999527260233545 -SMIM12 0.396299543247483 -ADC 0.00234311016336715 -ZMYM1 0.0017290006507811 -GJB3 0.00273307067844208 -C1orf94 0.00437226006687605 -AK2 0.00556558560437493 -A3GALT2 6.50302639229507e-07 -GJA4 0.239138208939641 -DLGAP3 0.999638515813562 -GJB4 1.96484561379576e-06 -ZNF362 0.928285965252321 -ZSCAN20 0.0719552830685617 -ZMYM4 0.999999928925947 -ZMYM6 1.40245953692462e-08 -HMGB4 9.96360941849729e-06 -GJB5 7.70660156496684e-05 -COL8A2 0.699343492871063 -KIAA0319L 0.188543868959937 -TEKT2 4.73097417544403e-09 -AGO3 0.999998843614557 -ADPRHL2 6.50306503732575e-05 -AGO4 0.990043812111039 -C1orf216 0.128378757752275 -MAP7D1 0.973584103721944 -CLSPN 0.991559393439728 -PSMB2 0.972351383142869 -AGO1 0.999999463471423 -NCDN 0.99673508374991 -EVA1B 0.656674967875198 -THRAP3 0.999996899183557 -SH3D21 0.000722997736993469 -TRAPPC3 0.810539219939377 -TFAP2E 0.000972259060989771 -LSM10 0.615647823094396 -STK40 0.991723985402898 -DNALI1 6.82031949142269e-08 -EPHA10 3.15992066275912e-18 -CDCA8 0.0971532321701097 -ZC3H12A 0.91163271519429 -MTF1 0.991394717050406 -C1orf122 0.123246499727265 -CSF3R 1.41619198119671e-06 -OSCP1 0.000148146568416105 -SF3A3 0.999895351853046 -RSPO1 0.00291051404723573 -FHL3 0.534417265883107 -MRPS15 0.000342016118820908 -GNL2 0.453032469584323 -SNIP1 0.905058048773074 -GRIK3 0.999980170163858 -YRDC 0.13339560775993 -MANEAL 0.00438904419096243 -INPP5B 7.43289930464084e-09 -MEAF6 0.730388139479782 -C1orf109 6.27363023706354e-08 -PPIE 0.980809839859493 -KIAA0754 0.0210361269465471 -PABPC4 0.992493064403533 -NT5C1A 8.15238589051518e-05 -GJA9 3.07324197077134e-06 -HPCAL4 0.0184227514017707 -HEYL 6.80881163426979e-07 -MYCBP 0.739328409179167 -UTP11L 1.26970219909462e-06 -MYCL 0.3588124729359 -BMP8A 0.456963119276428 -TRIT1 9.42968680674274e-10 -RRAGC 0.600078052257623 -BMP8B 0.774529935806127 -MACF1 1 -AKIRIN1 0.672015819577841 -NDUFS5 0.0982173317228148 -RHBDL2 2.70127816729767e-06 -PPT1 3.75207213169725e-05 -RLF 0.999999867034835 -ZFP69 8.55771991050002e-08 -CTPS1 0.932192403965688 -SCMH1 0.52410168415646 -TMCO2 0.03971131287527 -KCNQ4 0.985178281898531 -EXO5 0.000872651077294589 -SLFNL1 0.000108969289298797 -ZFP69B 2.52121150457695e-09 -SMAP2 0.014285645188747 -FOXO6 0.437580050850403 -COL9A2 0.182801205838876 -NFYC 0.631959350371475 -ZMPSTE24 1.25000649755402e-07 -RIMS3 0.00725110831997781 -CITED4 0.358265028581015 -CAP1 0.585940925968321 -ZNF684 0.00221741911028769 -MFSD2A 0.917671219949033 -HIVEP3 0.0308106016636644 -FOXJ3 0.977575009123256 -PPCS 0.00353633641897521 -ZNF691 0.417758649657401 -C1orf50 0.00701592646307591 -ZMYND12 0.00105994735075674 -SLC2A1 0.939808130156394 -YBX1 0.990640769249964 -GUCA2A 0.00607225846311219 -CLDN19 0.175565901482529 -GUCA2B 0.707935696188502 -PPIH 0.00475502689084187 -CCDC23 0.213154887650545 -FAM183A 0.0293267361122758 -LEPRE1 1.63942117634135e-17 -EDN2 0.0110864412384733 -ERMAP 5.8055284133168e-05 -CCDC30 6.06674580228951e-12 -RIMKLA 0.0873953268287957 -EBNA1BP2 2.3767005478956e-06 -PTPRF 0.999998378977356 -ATP6V0B 0.927635231427402 -C1orf210 0.00121963583096512 -B4GALT2 0.295417380860886 -KDM4A 0.999993865120135 -WDR65 8.58277032784158e-09 -HYI 3.15819250162145e-08 -MPL 1.43928006099179e-06 -DPH2 0.00684674768380938 -SLC6A9 0.0442530405880805 -ARTN 0.293100341552423 -SZT2 1.51746679777732e-07 -IPO13 0.972444338181171 -CDC20 0.000181853834795088 -MED8 8.1582621367423e-06 -TMEM125 0.000428556113626271 -ST3GAL3 0.573989459299218 -ELOVL1 0.223414530247304 -CCDC24 2.01106420911485e-08 -TIE1 8.71416663313257e-12 -PTCH2 6.1101240485129e-10 -MUTYH 8.56708501585961e-11 -RNF220 0.999277879441591 -ZSWIM5 0.116879095769383 -KLF17 4.24588312614059e-09 -TCTEX1D4 0.208823533681892 -DMAP1 0.336141633295794 -KIF2C 0.01719407223229 -TMEM53 0.0389751684862776 -BEST4 0.00309511388143714 -RPS8 0.965122842277358 -HPDL 0.0139648272169788 -UROD 0.000142209588904372 -ERI3 0.129756091189771 -EIF2B3 0.393440242907713 -PLK3 6.24924446856326e-05 -HECTD3 0.0170427799161936 -TOE1 6.58751882854325e-09 -MAST2 5.44402882251562e-11 -CCDC163P 0.143398568804261 -PIK3R3 1.40585793273596e-06 -UQCRH 0.218440721378243 -PRDX1 1.43818422373501e-07 -MMACHC 5.25633027461793e-14 -NSUN4 1.38867585570257e-06 -CCDC17 3.58916148308353e-13 -NASP 0.470216299614197 -FAAH 5.9295002678292e-07 -RAD54L 2.73718135268854e-13 -POMGNT1 1.68023697303463e-09 -LURAP1 0.220934118593464 -TSPAN1 0.000714382124602965 -TMEM69 0.000261682873521805 -TESK2 8.65426854901905e-06 -IPP 0.00253170996710155 -AKR1A1 0.000107486413477255 -LRRC41 0.999804640576002 -GPBP1L1 0.435324050435863 -MOB3C 0.0340049542449835 -MKNK1 0.000222399042685413 -CYP4B1 5.37386386780508e-10 -STIL 0.202687840102417 -CYP4Z1 5.28062048296512e-06 -ATPAF1 0.236382638181407 -CMPK1 0.319273509909851 -PDZK1IP1 0.000484064755406402 -CYP4X1 1.72089900913095e-06 -TAL1 0.824692214968038 -KNCN 0.0295306711881479 -TRABD2B 0.370916244398265 -DMBX1 0.915995646935682 -EFCAB14 0.000132862974740103 -CYP4A11 1.57399320908396e-15 -CYP4A22 1.4221825850504e-08 -RNF11 0.420327239136286 -BEND5 0.114990689141033 -TXNDC12 0.344869172542878 -CDKN2C 0.315707026353853 -FAF1 0.997397841844743 -ZFYVE9 0.943796743559468 -OSBPL9 0.998515312665247 -TTC39A 0.0983102549140287 -EPS15 0.241707066029501 -SLC5A9 6.41959687057975e-13 -BTF3L4 0.451300212005922 -ELAVL4 0.976912761697479 -AGBL4 3.57830057240453e-06 -RAB3B 0.156443019931872 -NRD1 0.878722429060876 -KTI12 0.0342938336572136 -SPATA6 2.02900598310508e-11 -ZCCHC11 0.999999999122232 -SCP2 0.000139759628696758 -NDC1 0.937525025656544 -DMRTB1 0.589036510844938 -GLIS1 0.0999809478306639 -MAGOH 0.747938336088651 -ZYG11B 0.999923789376919 -CC2D1B 4.76314820582514e-10 -CPT2 4.77178075381137e-07 -C1orf123 1.26488229435833e-07 -ORC1 3.38880226667018e-05 -GPX7 0.000179755480234412 -SELRC1 0.167434926950638 -ECHDC2 1.18082144336839e-07 -FAM159A 0.000284217822528371 -PODN 5.1967645599773e-07 -LRP8 0.999985760234446 -PRPF38A 0.996467618668032 -SLC1A7 1.86525618722239e-05 -ACOT11 1.33339142705338e-10 -HSPB11 0.00497874000170344 -CYB5RL 4.23010695021034e-05 -SSBP3 0.99975619603717 -YIPF1 0.0173793241634188 -DIO1 0.271104148641763 -LRRC42 1.66639189391607e-06 -PARS2 0.701898000015829 -TMEM59 2.23025067852854e-07 -MROH7 6.65107650339551e-19 -TCEANC2 2.81297991262072e-05 -CDCP2 6.92291104064707e-10 -TTC4 0.0439675923529379 -TTC22 0.000878027240110101 -FAM151A 3.92272933199048e-13 -LDLRAD1 0.000101665235918743 -MRPL37 0.000268371179907098 -C1orf177 2.53305443830598e-11 -JUN 0.46085190120742 -C8A 5.355640730752e-11 -MYSM1 0.0202316448544944 -TMEM61 0.00437577280284652 -FGGY 1.20951730816233e-11 -OMA1 3.51132911001781e-09 -DHCR24 0.969136893394347 -C1orf168 2.35652055532321e-30 -C1orf87 1.57688017827745e-17 -CYP2J2 4.51201698997771e-12 -C8B 1.49406934497858e-09 -PPAP2B 0.961834123262929 -PCSK9 1.02507611210468e-10 -PRKAA2 1.44261719898224e-05 -DAB1 0.98140856728469 -USP24 0.999999998496473 -TACSTD2 0.20524803232453 -BSND 4.41379060688424e-07 -HOOK1 4.15670073195207e-05 -ALG6 0.0553676261725129 -NFIA 0.999555166212873 -KANK4 5.3984986278488e-08 -ITGB3BP 1.47054021720334e-05 -DOCK7 0.771361085896655 -ANGPTL3 2.12015609401708e-07 -TM2D1 0.0420614829227396 -UBE2U 7.80931252869977e-08 -PGM1 9.96139807231456e-06 -ROR1 0.906688532334116 -USP1 0.993180568281562 -RAVER2 1.85996394365043e-06 -INADL 6.18135248541528e-26 -L1TD1 0.000340201048660737 -ATG4C 3.32761781234443e-09 -EFCAB7 1.67071925383672e-12 -CACHD1 0.838036969203847 -JAK1 0.995909680354616 -SGIP1 0.999651092711271 -IL23R 0.00649529618715747 -C1orf141 2.70036597974712e-05 -MIER1 0.96629546639685 -TCTEX1D1 0.00642468214043671 -LEPROT 0.0947893568489441 -PDE4B 0.709078616910536 -INSL5 1.51756497878115e-05 -DIRAS3 0.0372391763198298 -SERBP1 0.999863113808072 -IL12RB2 4.50998691872981e-06 -LEPR 0.999805342049916 -WDR78 7.87925768320976e-11 -GNG12 0.553351817862124 -AK4 0.23613336099277 -SLC35D1 0.001854200528779 -DNAJC6 0.99918835079312 -GADD45A 0.109847669303976 -TNNI3K 1.80292277016875e-38 -PTGER3 0.787642828876607 -TYW3 0.431871959845862 -CRYZ 1.14334039127866e-14 -FPGT 5.97096312971038e-08 -SRSF11 0.999787767134473 -ZRANB2 0.992881089843736 -DEPDC1 3.29623878527281e-07 -WLS 0.344541187034555 -NEGR1 0.951349394977358 -C1orf173 4.16253138952944e-32 -CTH 4.08793061635348e-05 -LRRC7 0.999998533487013 -ANKRD13C 0.999095558403675 -RPE65 1.45840005679569e-07 -FPGT-TNNI3K 1.84157554257575e-38 -HHLA3 0.00618097014298229 -LRRC40 2.64692039855136e-19 -LRRIQ3 3.22226837336838e-15 -IFI44 4.72292352590193e-14 -SLC44A5 0.0342286898388776 -FUBP1 0.999972830983476 -DNAJB4 0.840407621121713 -ST6GALNAC5 0.852521023463578 -RABGGTB 0.449469061672224 -NEXN 3.66202095881219e-06 -PIGK 0.000544787618840002 -IFI44L 2.21842256623261e-10 -LHX8 0.663323206439864 -ST6GALNAC3 0.178471681213117 -ASB17 0.00615869575211394 -GIPC2 3.41555177810974e-08 -ACADM 8.44476503475977e-10 -MSH4 3.6994716527544e-15 -PTGFR 0.760040674562793 -AK5 0.139499449417184 -ZZZ3 0.999729639003156 -USP33 0.996116690829413 -FAM73A 0.000750458579415592 -C1orf52 0.359076551650837 -WDR63 0.000118222164733869 -LPHN2 0.999999944952148 -LPAR3 0.786363329238024 -DDAH1 0.168276873038356 -SAMD13 0.128562761436203 -ELTD1 5.25882220113331e-07 -MCOLN2 1.32269877326023e-10 -PRKACB 0.612478408550855 -SYDE2 3.19709426065925e-12 -DNASE2B 3.78798985155026e-14 -BCL10 0.118213218716406 -SSX2IP 0.000829858792208633 -CYR61 0.882250775888852 -MCOLN3 3.77973883718057e-07 -TTLL7 0.268072469343805 -RPF1 9.47682922183822e-07 -CTBS 2.00761188893893e-07 -GNG5 0.524989345213255 -SH3GLB1 0.730421396838354 -CCBL2 3.04636359623202e-08 -SEP15 0.428149534913429 -GBP4 1.42218697793758e-09 -ODF2L 3.32070872906533e-09 -COL24A1 1.06341054664097e-25 -HS2ST1 0.535866622243903 -GTF2B 0.489078694212667 -GBP7 5.50946977464199e-11 -CLCA4 3.19440293023477e-09 -PKN2 0.999995222562088 -RP5-1052I5.2 0.0888231635700647 -GBP1 1.80843358162521e-12 -CLCA1 6.08038432284723e-06 -ZNHIT6 0.000536150774329766 -CLCA2 1.90835519560536e-20 -GBP3 5.83109623121067e-18 -RBMXL1 0.119596956167504 -GBP2 1.96948500969075e-05 -LMO4 0.816026560670216 -GBP6 2.45413567039759e-10 -HFM1 1.44957889668382e-23 -CDC7 0.352414094259261 -BTBD8 1.30361769669498e-06 -BARHL2 0.222344944286557 -ZNF326 0.977917716799787 -GBP5 7.95482106405718e-06 -GLMN 4.16913776813199e-06 -ZNF644 0.997328579642784 -EPHX4 0.033543926869158 -C1orf146 0.0240479302432628 -GFI1 0.029628557114147 -LRRC8C 0.0165279231134417 -EVI5 2.33071549244674e-06 -RPAP2 0.00208553433642619 -TGFBR3 0.0110547982037593 -BRDT 2.47163040334459e-06 -LRRC8B 0.806424943328372 -LRRC8D 0.868441355312111 -ABCD3 0.999695622624106 -FAM69A 0.0908652263134349 -TMEM56 0.338393703132694 -ARHGAP29 0.999986514079404 -ABCA4 1.26762782980402e-28 -F3 0.132021360809909 -CNN3 0.864370512768343 -RPL5 0.994762228681169 -BCAR3 0.916779854975838 -RWDD3 1.52122961502874e-06 -MTF2 0.994599740764267 -TMED5 0.00243713073785069 -DR1 0.835491729483673 -FNBP1L 0.965504529201717 -ALG14 0.000832660846870737 -SLC44A3 1.8199523853244e-24 -DNTTIP2 0.000217903722961202 -RP11-57H12.6 0.00274643100808391 -GCLM 0.414918212155138 -SNX7 0.0288388617246868 -DBT 0.000147622487439407 -FRRS1 5.4989943969967e-08 -HIAT1 0.983243231071697 -LPPR4 0.972616087917465 -TRMT13 2.92966422052012e-05 -SLC30A7 0.0289920473573277 -LPPR5 0.959898117418367 -DPYD 4.18972244079049e-09 -CDC14A 0.0156184793096619 -PTBP2 0.992693429228573 -LRRC39 0.0397074605005753 -AGL 2.30929380571103e-15 -GPR88 0.754055177236605 -VCAM1 0.781503144443611 -RTCA 0.00292097800955511 -SASS6 4.9987952418433e-05 -EXTL2 3.15804988853622e-05 -PALMD 0.0369520095811702 -SLC35A3 0.0693153753308512 -SLC25A24 4.89817247272209e-09 -AMY1C 0.844157662030798 -HENMT1 1.41529040753691e-06 -OLFM3 6.96790168770402e-05 -RNPC3 0.525297994226153 -AMY2B 7.64543781687526e-09 -NTNG1 0.4410311282378 -FAM102B 0.0479307719355573 -PRMT6 0.0241276210660794 -AMY2A 0.00560391741240498 -S1PR1 0.484814894860016 -AC093157.1 0.154674834678079 -NBPF4 0.346635143601408 -PRPF38B 0.990908108110014 -DPH5 0.00189943547170022 -NBPF6 0.0874538512080049 -VAV3 0.0200593234937473 -AMY1A 0.365183316916371 -COL11A1 0.999980608468386 -ATXN7L2 0.718954812432385 -PSRC1 1.74717788563073e-06 -TMEM167B 0.632476718728509 -KIAA1324 2.14864520738644e-08 -TAF13 0.0198501953204612 -WDR47 0.90566161819711 -SORT1 0.999926560036891 -PSMA5 0.974255885097096 -MYBPHL 0.00461844098878081 -CELSR2 0.999999199832348 -CLCC1 0.0267100875839262 -SARS 0.999150650957633 -STXBP3 7.39663613294889e-06 -C1orf194 2.50029511352176e-07 -AKNAD1 8.20527848932304e-19 -AMIGO1 0.888492588974354 -FNDC7 0.000318365257387006 -SYPL2 0.0167710987562036 -CYB561D1 0.0158304191038284 -GPSM2 2.9412972070079e-10 -SLC6A17 0.962734835648401 -GPR61 0.801488898268086 -GSTM4 0.000917344712640999 -GNAI3 0.038811277618943 -CSF1 0.939718909454486 -LAMTOR5 0.00711604756483594 -ALX3 0.208670051874219 -GSTM1 0.345713720441091 -GSTM2 0.00890200357706731 -GSTM3 0.00057258920556302 -RBM15 0.999853092554739 -GSTM5 0.000214167029024381 -AMPD2 0.0085424965783861 -UBL4B 0.000847798204150755 -EPS8L3 0.000100217168096749 -KCNC4 0.00053422527064709 -GNAT2 0.00815865202254078 -AHCYL1 0.999795279646545 -SLC16A4 0.00583523308352845 -STRIP1 0.130901315990928 -DDX20 4.187651178714e-07 -KCNA10 0.00305948856082549 -DENND2D 1.02695227272951e-05 -LRIF1 0.000245000652306933 -RAP1A 0.934189797815675 -ADORA3 0.00605730645545196 -DRAM2 0.00139586626243694 -KCNA2 0.884173956445609 -CHI3L2 6.54220595861069e-07 -CD53 0.0240198281448552 -C1orf162 0.00613131644818344 -WDR77 0.0157265712626212 -OVGP1 0.000935883751426529 -ATP5F1 0.0128675263722768 -PIFO 7.54735435611498e-05 -CEPT1 0.946564689940993 -FAM212B 0.00359051662635945 -PROK1 0.0206691663843015 -CHIA 2.25649100389894e-15 -DCLRE1B 0.107858132118987 -FAM19A3 0.0271473784019524 -BCL2L15 0.00361468827063082 -HIPK1 0.999942914529477 -MAGI3 0.570580157400499 -ST7L 1.94396958967683e-06 -KCND3 0.803752595406802 -LRIG2 3.28910293719164e-12 -CTTNBP2NL 0.141381251992425 -OLFML3 0.000588286969051829 -CAPZA1 0.983027524743633 -RSBN1 0.805139687607845 -MOV10 0.998090427630705 -PPM1J 2.30817311285829e-07 -PTPN22 3.0777571006681e-16 -SLC16A1 0.826067878054453 -WNT2B 0.285537291393408 -RHOC 0.586036085485523 -AP4B1 2.69463741752042e-08 -PHTF1 5.47464863886936e-18 -SYCP1 0.949997702198387 -NRAS 0.912772900891261 -SYT6 0.0328455242915539 -TRIM33 0.999998355934464 -NGF 0.704368811874854 -BCAS2 6.52504489211884e-05 -CSDE1 0.999951563731616 -ATP1A1 0.999993850305473 -CD58 0.299199171430379 -SIKE1 0.0729823085203998 -CASQ2 1.06548301273598e-06 -AMPD1 3.77976185034765e-12 -TSHB 0.00575808545782517 -IGSF3 0.987084919325614 -SLC22A15 8.6598992720709e-06 -DENND2C 1.70408687930238e-07 -MAB21L3 0.000490218809434059 -NHLH2 0.537457456619661 -TSPAN2 0.000100586967317338 -VANGL1 0.533615186185259 -HAO2 4.4763295317251e-08 -WDR3 3.05076498982483e-07 -MAN1A2 0.996263145196637 -VTCN1 7.28889632660935e-09 -PTGFRN 0.6388592328477 -TBX15 0.877333976211489 -TRIM45 1.44830918595153e-06 -SPAG17 9.34771220873125e-16 -ZNF697 0.191081026945304 -HSD3B1 8.51173207421434e-05 -WARS2 0.601342004604768 -HSD3B2 1.21147217431287e-06 -CD101 5.54031092302461e-10 -TTF2 7.3515283462504e-16 -FAM46C 0.523539097501889 -GDAP2 8.51357562104278e-05 -HMGCS2 1.06116787483877e-08 -CD2 0.768323768543511 -PHGDH 0.000436998677210205 -REG4 5.62414830360332e-05 -NBPF10 2.80946400390907e-13 -ADAM30 0.00193807290428196 -LIX1L 0.116630313625694 -FAM72B 0.251829881310335 -PEX11B 0.000510737313623795 -ANKRD34A 0.974591387104345 -POLR3GL 0.0024402126746499 -HFE2 0.0123303974512737 -NOTCH2NL 0.00010062258971701 -FCGR1B 0.676508623032471 -AL592284.1 0.336126600836845 -RBM8A 0.962186022966541 -NOTCH2 0.999999993249444 -TXNIP 0.252140354472324 -PPIAL4G 0.606751613079552 -FAM72D 0.580818100007918 -GPR89B 0.791699861953137 -ANKRD35 4.67636131494537e-13 -NBPF12 0.210636207445938 -BCL9 0.831846216932657 -PDZK1 0.000134102441018778 -ACP6 3.14409809921214e-05 -GJA8 2.67760459251749e-05 -CHD1L 1.05042366445767e-20 -POLR3C 8.6570108559178e-06 -GPR89A 0.847988631121754 -GJA5 0.09799649643541 -CD160 1.90559903419166e-05 -PIAS3 0.998174980398239 -PRKAB2 0.767108491529973 -RNF115 0.0806347440374519 -ITGA10 8.55370308285704e-11 -NUDT17 0.00537990843402384 -FMO5 3.69166290202894e-15 -PPIAL4A 0.377823123108992 -HIST2H2BE 0.487682589452728 -HIST2H3PS2 0.135983520424883 -NBPF15 0.123939063679527 -FCGR1A 0.97163343240963 -NBPF16 0.0907606604548231 -NBPF20 0.000445919208521471 -HIST2H2BF 0.0259999814401532 -HIST2H3D 0.498937279946072 -CA14 1.43471644090703e-09 -TARS2 1.87455824083767e-08 -OTUD7B 0.100123440515689 -HIST2H2AB 0.216215034165356 -SV2A 0.578982694774458 -VPS45 0.00030556962283822 -SF3B4 0.918007232108898 -MRPS21 0.353450051428985 -HIST2H2AC 0.209670054818694 -C1orf54 0.178651547006617 -APH1A 0.132136061884529 -C1orf51 0.804527837676217 -BOLA1 0.634184000881994 -ANP32E 0.976918663468077 -PRPF3 0.999998843810724 -ECM1 7.32850722654138e-08 -PLEKHO1 0.949230797050779 -MTMR11 7.32567938847539e-13 -RPRD2 0.999977310558099 -ANXA9 3.36086004793863e-14 -BNIPL 1.0279554795193e-09 -GABPB2 0.00262905195509113 -MCL1 0.950092967336216 -PRUNE 0.0107617657791834 -HORMAD1 0.00312691335861907 -C1orf56 0.00131728385359755 -GOLPH3L 0.0221067463015886 -ARNT 0.976348195268955 -ADAMTSL4 7.08734668179842e-16 -MLLT11 0.473311552387312 -CTSS 0.628282928532702 -ENSA 0.162369766475176 -SETDB1 0.999996683969478 -CERS2 0.91016304279668 -CTSK 0.000135210885342523 -FAM63A 8.24250956861272e-06 -SEMA6C 5.65313335596491e-05 -CDC42SE1 0.0135194909211455 -PIP5K1A 0.0145862989024307 -PI4KB 0.998716210797651 -CGN 1.82319246593754e-22 -SNX27 0.999884818815405 -TNFAIP8L2 0.504728364704239 -SELENBP1 1.22411207379355e-06 -LYSMD1 0.181950236021973 -POGZ 0.999999128125461 -TMOD4 1.33270686836563e-07 -PSMB4 0.398813284714522 -RFX5 0.000136785945750611 -TUFT1 0.0180800994157088 -VPS72 0.249428570077118 -PSMD4 0.984312091842397 -SCNM1 4.72848403910251e-05 -ZNF687 0.975942572522876 -CELF3 0.2931429110507 -TCHHL1 2.23453010094714e-08 -THEM4 0.000241347691647955 -S100A10 0.173245480827353 -CRCT1 0.00367304007975833 -S100A11 0.0501061591847237 -OAZ3 9.17261329992055e-05 -TDRKH 0.00696242282858822 -TCHH 3.87496343902758e-23 -CRNN 0.000495360508958453 -LCE3E 0.0390009274705493 -RPTN 3.17531967976647e-18 -THEM5 5.98125901231817e-07 -MRPL9 0.0513078499662132 -FLG2 4.64992449263283e-41 -HRNR 5.01202544702428e-29 -RORC 0.997845135319209 -LINGO4 0.00285409743434757 -LCE5A 0.0767260194114967 -LCE1B 0.0272674911272321 -LCE2D 0.139231288431163 -LCE1C 0.0275164497301328 -LCE1A 0.000409833656946099 -LCE2C 0.0226062040752681 -IVL 3.43124628664551e-09 -LCE3B 0.039623989044318 -LCE3A 0.496361201281267 -LCE2A 0.00619380141821062 -LCE3D 7.91048601058223e-05 -LCE1F 0.0294987722043082 -LCE3C 0.496169124945965 -LCE4A 0.00328018180284451 -KPRP 7.82565128996116e-14 -LCE1D 0.00356754650118208 -SMCP 0.0429932404361666 -LCE2B 0.137251509220331 -LCE1E 0.000399700058911427 -SPRR2E 0.15458733678847 -SPRR2A 0.160255855292028 -LOR 0.179479999341018 -SPRR2B 0.15744268643288 -SPRR4 0.582181678693793 -PGLYRP4 2.63028984617915e-08 -S100A9 0.667440117616727 -SPRR1B 0.17260904615434 -S100A7L2 0.558124073655943 -SPRR1A 0.175108853992108 -PGLYRP3 9.00246757206822e-05 -SPRR2D 0.00368097397742855 -S100A7A 0.0315992767749722 -S100A12 0.0335297458461187 -S100A8 0.186216605301329 -SPRR2F 0.00362203147645598 -LELP1 0.000473718090816196 -SPRR3 0.00604296707083471 -SPRR2G 0.0266080186616705 -S100A4 0.00465145853748136 -SLC39A1 0.167076829803909 -S100A3 0.000978354164779786 -S100A1 0.00465602079501881 -CHTOP 0.998109469154056 -CRTC2 0.996361791046642 -S100A5 4.81203056762956e-05 -S100A16 0.00563845182351615 -INTS3 0.999997023490929 -S100A13 0.0351531421862098 -NPR1 0.000172508543840191 -S100A6 0.178917966295076 -S100A14 0.0570469536230336 -ILF2 0.997052017177466 -GATAD2B 0.998594716203308 -SLC27A3 7.80147738518240e-11 -S100A2 0.000135122428502476 -S100A7 0.547478872262447 -SNAPIN 3.04880662881494e-05 -DENND4B 0.999987069079939 -RAB13 0.57012570509712 -HAX1 1.10582340278236e-05 -JTB 0.645223905316483 -TPM3 0.191983984043152 -AQP10 0.0152782932027765 -PMVK 0.000305454915643329 -UBAP2L 0.999999873126418 -IL6R 0.0478690367242407 -SHE 0.721620118578427 -KCNN3 0.864940881345047 -ADAR 0.907595373477161 -C1orf189 0.000114764896185549 -CREB3L4 8.06202744664506e-05 -C1orf43 0.173985957447014 -TDRD10 2.45421655192587e-06 -CHRNB2 0.720254345017317 -RPS27 0.697777961357601 -UBE2Q1 0.969363486984384 -NUP210L 0.144640619732186 -ATP8B2 0.999564591733884 -CKS1B 0.723280936456517 -PBXIP1 5.79843921369484e-07 -EFNA3 0.18056410470307 -SHC1 0.341634863000658 -MTX1 0.198221290051836 -DPM3 0.233470170067034 -THBS3 1.20600565280442e-08 -EFNA4 0.000252891317706202 -ADAM15 1.07719204651477e-11 -PYGO2 0.923104365059159 -LENEP 0.0322826229786669 -EFNA1 0.872063427950098 -SLC50A1 0.130229792296048 -DCST1 3.88695922784292e-15 -FLAD1 0.0917935111458052 -ZBTB7B 0.837393370882557 -TRIM46 0.998652125444883 -KRTCAP2 0.0299704903065574 -MUC1 0.730964975196719 -DCST2 1.45881629274481e-09 -ASH1L 0.999999999999834 -SSR2 0.822108921079836 -RIT1 0.666809792340233 -SCAMP3 0.0128944102681846 -MSTO1 0.0418044849918912 -GON4L 0.999998891638014 -PKLR 1.00020289233933e-05 -KIAA0907 0.99711361843545 -CLK2 0.999952949082341 -YY1AP1 0.000145221258212536 -GBA 0.0340405400496017 -RXFP4 0.00549581832537321 -ARHGEF2 0.99999323549835 -HCN3 0.0150933826344395 -SYT11 0.801740134718319 -UBQLN4 0.997522419654586 -FDPS 0.00175127849063184 -RUSC1 0.949429117518656 -DAP3 1.9076333934558e-05 -FAM189B 0.000482815313135408 -VHLL 0.00290057346415176 -RAB25 9.31079417686485e-06 -TSACC 0.0697917263737303 -SEMA4A 0.615371620982326 -PAQR6 0.000721604365184446 -LAMTOR2 0.481086311682732 -BGLAP 1.75722490280257e-05 -PMF1 1.71367442696473e-05 -C1orf85 4.68709760252752e-08 -RHBG 3.72564357556274e-10 -LMNA 0.993449023376761 -IQGAP3 6.47051186060707e-16 -MEF2D 0.998547093289291 -CCT3 0.998745412971341 -PMF1-BGLAP 1.71367442696473e-05 -MEX3A 0.881462711195155 -TMEM79 3.49884123421551e-07 -C1orf61 0.104422489726842 -SMG5 0.998179752831908 -SLC25A44 0.247810862226725 -INSRR 4.91565760465697e-07 -APOA1BP 1.72708938017144e-06 -PEAR1 1.18896498529681e-14 -CRABP2 0.00816686942900527 -LRRC71 0.00904921773201473 -GPATCH4 1.68775621140413e-07 -ETV3L 1.20827466358355e-05 -MRPL24 0.00149122661138067 -HDGF 0.269699273955011 -BCAN 0.00361212462845155 -NES 2.06955630735523e-05 -NTRK1 0.000424899217244118 -ISG20L2 0.821397244338996 -ARHGEF11 0.999945339206174 -PRCC 0.921293121521907 -TTC24 6.58039647151808e-05 -HAPLN2 1.05244127720139e-05 -RRNAD1 2.11535175142641e-08 -SH2D2A 8.43213730306944e-05 -ETV3 0.783799556047856 -CD1B 1.15095187891101e-07 -FCRL1 0.00159526703104064 -FCRL4 1.59511072407105e-07 -FCRL2 0.000160040383245631 -KIRREL 0.95946008263139 -OR10K1 0.0130991891900967 -FCRL5 7.49244691962338e-14 -OR10R2 0.0443756510558884 -FCRL3 4.5604025041299e-18 -CD1E 8.77644488499941e-13 -CD5L 7.09602208888946e-07 -OR10Z1 0.00736423007934796 -CD1C 6.43880889369437e-07 -CD1A 5.0115630563305e-17 -CD1D 0.000899328621662704 -OR10X1 0.00590274236426999 -OR10T2 0.0631105268901614 -OR10K2 8.0533546777969e-05 -OR6Y1 0.0179818972231652 -OR10J5 0.723391071464347 -SPTA1 5.85298929647153e-05 -OR6K6 0.0104831042185149 -OR10J1 1.59229720392064e-08 -OR6N1 0.00123986038668199 -IFI16 0.00295604093058718 -CADM3 0.975630650500283 -AIM2 9.0084267551464e-08 -APCS 0.0386375435691614 -OR6N2 0.0234399156655135 -FCRL6 5.08221240608822e-14 -DUSP23 0.0411468265638501 -MNDA 7.23077353015599e-11 -OR6K3 0.0069063678864482 -DARC 0.000273605757450067 -PYHIN1 0.000917067605008323 -FCER1A 0.0025580283628798 -OR6K2 6.62918854479771e-05 -OR10J3 0.00103942838422063 -CRP 3.06308864362311e-05 -IGSF8 2.27585228881138e-06 -ATP1A4 1.89733270588042e-11 -PEX19 0.0429221720976364 -IGSF9 0.568910879897229 -VSIG8 0.00315999833233031 -PIGM 0.000916857647096851 -SLAMF9 0.00785783195511103 -CASQ1 1.03907088565768e-09 -KCNJ9 0.583029242446481 -KCNJ10 0.59838882297069 -TAGLN2 0.00329073326368993 -SLAMF8 1.70506204430406e-06 -DCAF8 0.999730107307524 -COPA 0.999999997609881 -C1orf204 0.0933681491982905 -ATP1A2 0.600219587089565 -NCSTN 0.999982342874537 -CCDC19 2.35996200641365e-10 -PEA15 0.698679171533243 -NHLH1 0.640239274537506 -ITLN2 1.15271947267602e-05 -PFDN2 0.219933484264837 -ITLN1 0.00489119365441958 -F11R 5.54288059660764e-05 -SLAMF7 0.00654462638539223 -CD48 0.000152358839925206 -USF1 0.381283031966058 -CD244 0.00174717204516475 -KLHDC9 5.36703786259885e-06 -LY9 4.14080222823562e-10 -PVRL4 0.439337892970362 -CD84 0.000390056564945539 -SLAMF1 0.135406431574352 -SLAMF6 0.356879514961895 -NIT1 0.000861524962795638 -UFC1 0.0899541883849323 -VANGL2 0.948574651924172 -DEDD 0.869503209773923 -ARHGAP30 0.968957887758364 -FCGR2B 0.0474026079439954 -B4GALT3 0.0208228744149612 -FCGR2A 0.000150862363564485 -APOA2 0.00943705539989373 -C1orf192 4.99767687708523e-06 -SDHC 0.0954199560781008 -FCER1G 0.635845638352269 -USP21 0.0746516537664707 -TOMM40L 0.744035828405772 -ADAMTS4 0.00546593980671702 -HSPA6 0.461296068531822 -MPZ 0.691715780756532 -FCGR3B 3.30211049830827e-05 -NR1I3 0.000355219683159767 -NDUFS2 0.99773539454649 -FCRLA 0.000166358002713443 -FCGR3A 1.22273626907589e-05 -PPOX 0.328331759509175 -PCP4L1 0.223985830023401 -FCRLB 1.19992605936002e-08 -UHMK1 0.729319451779304 -ATF6 3.10664680607037e-05 -RGS4 1.59300274695159e-05 -OLFML2B 3.02036832631922e-06 -HSD17B7 0.00175450778717878 -MGST3 0.00715304129824559 -SH2D1B 0.0598833646548052 -PBX1 0.910582151189653 -NUF2 6.55912662381588e-05 -RGS5 0.0404998864654464 -RXRG 0.937024401992312 -LRRC52 0.00132907118787168 -C1orf110 1.05804561663551e-05 -DUSP12 0.00353533720698026 -UAP1 0.908075010378527 -LMX1A 0.901260324312874 -DDR2 0.990992372312246 -C1orf111 2.10439313677877e-05 -NOS1AP 0.119913961376149 -C1orf226 0.723357168775303 -GPA33 1.49713378108759e-06 -FAM78B 0.770974373780866 -MAEL 0.0212546382876771 -ALDH9A1 1.29139214945887e-05 -CD247 0.661382967025913 -ADCY10 5.85120000034897e-26 -TMCO1 9.55325778347458e-07 -DCAF6 0.996908923107335 -MPZL1 0.327816834049089 -MPC2 0.449429466744431 -CREG1 0.0170794446011191 -RCSD1 0.108221839863747 -DUSP27 2.04584346521462e-15 -POGK 0.917279174747958 -UCK2 0.962082764358181 -ILDR2 0.398939847020927 -POU2F1 0.913950638110934 -TADA1 0.358858662861777 -GPR161 0.0295792897121091 -METTL18 0.0289350542238762 -BLZF1 7.04847210432784e-06 -CCDC181 3.80247233403694e-07 -ATP1B1 0.995564605006206 -KIFAP3 0.00197154943265453 -XCL1 0.088160228432048 -DPT 9.10510156884477e-05 -SELP 4.62464817320191e-20 -XCL2 0.0874325391165776 -C1orf112 5.98150986824657e-08 -SFT2D2 0.00394965055414437 -NME7 0.00352847685132706 -SELE 1.6649159169351e-08 -SCYL3 0.547053807767411 -F5 4.69402330698069e-08 -SLC19A2 0.00428587935441669 -TBX19 2.79914141349298e-05 -TIPRL 0.867249670452818 -SELL 0.00173463089981873 -FMO2 0.00129017983136937 -MYOC 5.01978488588844e-08 -FMO4 2.40849026007635e-09 -PRRC2C 0.999999999976013 -C1orf105 0.000319847693203247 -GORAB 6.82629373307261e-06 -DNM3 0.028276990644479 -FMO1 5.09733210470965e-07 -VAMP4 0.919995933830113 -MROH9 2.468587335044e-06 -SUCO 0.302497744042791 -FASLG 0.611670213878948 -FMO3 2.82794197226029e-09 -PRRX1 0.752904237310255 -PRDX6 0.00998976782458624 -TNFSF4 0.12523000717497 -FMO6P 0.376800998137273 -METTL13 0.00133198019797483 -PIGC 0.000110183266434322 -TNFSF18 0.000468355604968885 -MRPS14 0.00165874458756506 -DARS2 4.40767877928912e-09 -PAPPA2 0.00125005429153315 -RFWD2 0.998566093485584 -RC3H1 0.999539902744329 -TNN 5.19247511001232e-15 -SLC9C2 1.18824028993333e-06 -RABGAP1L 0.0891727139857161 -CACYBP 0.943386849157678 -SEC16B 4.43622376673842e-13 -SERPINC1 0.993263587241958 -ZBTB37 0.734036618249105 -ANKRD45 0.0198872747296348 -CENPL 0.513926394303849 -KLHL20 0.0616770822299398 -ASTN1 0.999415997291979 -BRINP2 0.999086308312748 -TNR 0.987762731547826 -GPR52 0.0654585923633591 -C1ORF220 0.000458581980652934 -IFRG15 0.702840889380842 -FAM163A 0.579850964182797 -ANGPTL1 1.52668512765821e-08 -SOAT1 1.665002779751e-05 -ABL2 0.00970257687397593 -LHX4 0.401093501395259 -TDRD5 0.975818615175016 -TOR1AIP1 0.0646147824983602 -CEP350 0.999996390363333 -AXDND1 1.80353379874149e-15 -TOR3A 2.47193997160645e-08 -FAM20B 0.285813780362229 -NPHS2 0.00896414230475842 -TEX35 0.00166477140275049 -RALGPS2 0.922194824062516 -TOR1AIP2 4.03605255306865e-05 -QSOX1 6.78457250016221e-05 -RASAL2 0.226449659060918 -RGS8 0.520349598238871 -GLUL 0.977842592811399 -TEDDM1 0.084146705930434 -LAMC2 7.93300382052603e-05 -CACNA1E 0.999999999999934 -IER5 0.666267931394036 -SHCBP1L 7.09410137011176e-10 -MR1 5.61258291225197e-09 -NPL 4.51265435659546e-07 -KIAA1614 2.19336786808695e-13 -RNASEL 8.98220456476748e-09 -DHX9 0.999999986154664 -STX6 0.0198491170645574 -NMNAT2 0.943848445340391 -LAMC1 0.999999624623106 -XPR1 0.998119588301853 -ZNF648 8.27115198132611e-06 -ACBD6 0.0649592587219742 -RGS16 0.00900264875905795 -APOBEC4 0.000618475417657442 -SMG7 0.999981493421641 -RNF2 0.944004162174101 -IVNS1ABP 0.999065766116616 -TRMT1L 0.939618900830471 -FAM129A 1.39592253616035e-13 -NCF2 8.50962248758179e-05 -TPR 0.999999999996002 -RGL1 0.987846908541125 -OCLM 0.0173290392628945 -PRG4 0.469279559391241 -COLGALT2 5.01784059691338e-07 -SWT1 0.117421725145305 -ARPC5 0.772685974822978 -EDEM3 0.122702493142942 -HMCN1 2.19206065668674e-18 -C1orf21 0.81911661413853 -C1orf27 1.38118318297717e-06 -TSEN15 0.504749058385151 -CFHR2 8.62005163564686e-09 -RGS2 0.00294511869423358 -CFH 0.99963096815145 -RGS18 0.0908283672627467 -KCNT2 0.666802213991112 -PDC 2.22523081961224e-06 -B3GALT2 0.491100476141356 -UCHL5 0.78109674793509 -GLRX2 6.50645483475157e-05 -CFHR3 1.21901547639532e-05 -RGS21 0.00740545430462791 -RGS13 9.33798010643176e-05 -BRINP3 0.00375909281013884 -CFHR1 0.000909321621156627 -RGS1 0.635710552007249 -PTGS2 0.999033115984394 -CFHR4 1.898128871656e-13 -TROVE2 0.0190448996422325 -PLA2G4A 0.00110001839424313 -CDC73 0.999958508392824 -CFHR5 9.56874096632543e-22 -KIF21B 0.999414089961557 -ATP6V1G3 0.0305017788865879 -ASPM 6.16438991946625e-26 -KIF14 6.0274856650418e-05 -C1orf53 0.10469872738464 -DDX59 0.00107791458335624 -NEK7 0.707657760923798 -C1orf106 0.555282612544487 -CACNA1S 9.55874082626219e-08 -NR5A2 0.959085110774338 -CAMSAP2 0.999973881501979 -DENND1B 0.636578248354416 -ZNF281 0.951671589857101 -F13B 2.13259736615404e-05 -GPR25 0.00563545142572482 -ZBTB41 0.76962740291043 -LHX9 0.941757643329135 -CRB1 3.35697504496476e-09 -PTPRC 0.999941156148536 -CSRP1 0.00342203414248425 -TMEM9 0.298539881699223 -ELF3 0.986666748385297 -TIMM17A 0.243777584003779 -SHISA4 0.00107148238892978 -IPO9 0.999992154750332 -TNNI1 0.120125044584648 -RNPEP 4.80666222710557e-11 -PHLDA3 0.527854532202414 -GPR37L1 2.88015901916168e-07 -IGFN1 2.50313046386532e-18 -ARL8A 0.630040288339089 -PKP1 0.00480236370151161 -NAV1 0.999999985195655 -TNNT2 0.01285284006076 -LMOD1 0.790872726605776 -PTPN7 2.56582220393352e-07 -LAD1 4.12856291165876e-08 -KDM5B 5.09420142344633e-05 -ADORA1 0.0212580375414267 -TMEM183A 0.948747425039997 -CHIT1 1.39253489248215e-09 -PPFIA4 0.00151553282447576 -CHI3L1 0.00112581158404786 -UBE2T 0.000369195253169518 -SYT2 0.88781098862506 -FMOD 0.0495813811462611 -CYB5R1 9.32776750510642e-09 -RABIF 0.0252902573574674 -LGR6 4.08845719461255e-05 -MYBPH 3.22430226765915e-11 -BTG2 0.0489784871870145 -PRELP 0.00373648581113307 -ADIPOR1 0.592753905673148 -MYOG 0.740012060346863 -PPP1R12B 0.124454641728848 -KLHL12 0.00808698785950803 -PPP1R15B 0.161223927951919 -KISS1 0.524779455234627 -GOLT1A 0.0387578834234533 -LRRN2 0.220781250034657 -PIK3C2B 0.976238394768661 -REN 0.00660413891460337 -ZC3H11A 0.997151604742134 -ATP2B4 0.521756389409679 -MDM4 0.998569577969579 -PLEKHA6 0.981969069730327 -ETNK2 0.00711885369597901 -RBBP5 0.995054147429424 -SNRPE 0.891456792044026 -LAX1 4.68312858821734e-07 -TMEM81 0.000222028741737008 -CNTN2 0.129621135189604 -OPTC 4.3127291120927e-07 -SOX13 0.964099530137052 -NFASC 0.998762678321666 -C1orf186 0.00189512675148331 -TMCC2 0.288835546910598 -DSTYK 0.147285745754517 -CDK18 7.15896735407714e-08 -SLC41A1 0.705784064695467 -MFSD4 0.0099886567002245 -AVPR1B 2.82255376407223e-05 -RAB7L1 0.790354891047754 -LEMD1 0.00457260632601518 -SLC45A3 0.0368495348530263 -SLC26A9 0.0029854587016256 -NUAK2 3.1843015314192e-05 -KLHDC8A 1.5912847668424e-05 -ELK4 0.0845886750240457 -CTSE 4.86866962963033e-07 -PM20D1 1.26770298960659e-09 -IKBKE 0.804391777009201 -NUCKS1 0.979237657935801 -IL19 0.0203202325026012 -PIGR 0.650095686646365 -FAIM3 0.000560563623745146 -CR2 2.16539872051034e-11 -MAPKAPK2 0.996185444591235 -RASSF5 0.248711065765209 -CD55 2.49092265860477e-07 -IL24 0.00271588782691559 -C4BPA 0.0127393583379383 -C1orf116 0.371958031808421 -EIF2D 6.59630829154375e-06 -DYRK3 0.000220921842662409 -IL10 0.0291622262123568 -C4BPB 2.57853683497245e-06 -YOD1 0.543401293595549 -FCAMR 8.00343370771682e-06 -PFKFB2 0.0010886274208406 -IL20 0.00253917759019062 -CR1 9.34032929712518e-08 -C1orf147 0.0120639015558244 -DIEXF 0.0492348597469146 -CD34 0.00344956865429019 -TRAF5 8.829041147296e-06 -HHAT 0.000341683761055846 -CD46 0.000191603012709758 -RCOR3 0.672007745805069 -SYT14 0.966548706607067 -C1orf74 0.489345231114962 -CR1L 3.55709649735169e-15 -HSD11B1 0.691555250680053 -G0S2 0.153689954137791 -IRF6 0.975119180790352 -LAMB3 1.36402401238307e-09 -PLXNA2 0.993981181863515 -CAMK1G 0.101614386605182 -RD3 0.0975162265688966 -SLC30A1 0.913544366960314 -KCNH1 0.333014560273438 -TRAF3IP3 1.3764917816926e-06 -SERTAD4 0.641278925379282 -PROX1 0.993426962817253 -NENF 0.00299100360136081 -TMEM206 8.00777346701742e-06 -LPGAT1 0.967547481345112 -DTL 0.0070133816764049 -SMYD2 0.00536893714935113 -C1orf227 0.27160333000862 -RPS6KC1 0.0204400966055895 -INTS7 0.860980155121656 -ANGEL2 0.121064258682459 -NEK2 8.72367756771365e-07 -BATF3 0.0307613819993955 -NSL1 0.043155916748521 -FLVCR1 0.00037308554680706 -PTPN14 0.991959026069808 -ATF3 0.276113481429884 -FAM71A 2.16426906493996e-10 -PPP2R5A 0.899520424028407 -VASH2 0.81958256467456 -TATDN3 4.62050476662264e-05 -GPATCH2 9.6600306030973e-05 -TGFB2 0.9891155078203 -MARC1 8.19879290549747e-05 -MARC2 0.0326007029745028 -HLX 0.561219969045613 -MARK1 0.990825675842053 -SPATA17 0.00473910823610697 -RRP15 0.00163197039115739 -KCNK2 0.339842885035151 -ESRRG 0.93661120997453 -C1orf115 0.283640867396314 -BPNT1 0.00021897484271604 -KCTD3 0.986866111092156 -RAB3GAP2 0.99873648274446 -SLC30A10 0.921869997532192 -USH2A 3.68100336207458e-43 -LYPLAL1 3.45406097372974e-08 -EPRS 3.847395094191e-07 -CENPF 2.12598447439069e-25 -IARS2 0.472741795319536 -TAF1A 6.60087794025323e-07 -CAPN8 0.0151809363825236 -CNIH4 0.0847249901890333 -DISP1 4.23342758464293e-06 -AIDA 0.0823723820518631 -FBXO28 0.930139055201687 -NVL 7.75724236417881e-12 -MIA3 0.47138810555393 -DEGS1 0.859651068829934 -TLR5 5.68654860439007e-09 -TP53BP2 0.00201851813532473 -CAPN2 1.61617931384536e-11 -HHIPL2 1.14241085217888e-17 -C1orf65 5.55983921321795e-11 -WDR26 0.99967739101451 -CNIH3 0.381818439065843 -DUSP10 0.499521469849817 -FAM177B 9.20960342032327e-06 -SUSD4 0.00457175417443286 -BROX 2.4755364239274e-05 -DNAH14 8.77000190556253e-06 -ENAH 0.995700037438515 -LBR 0.997025227192741 -PARP1 0.00699693078764991 -SRP9 0.308171838775694 -ACBD3 0.981823329864037 -PSEN2 0.0270141824537153 -C1orf95 0.0920540809601597 -EPHX1 1.6189441694091e-07 -LEFTY1 6.88020467750251e-05 -PYCR2 0.00506294198593209 -SDE2 5.17001532782485e-07 -MIXL1 0.0428902666081295 -LEFTY2 0.122897476061549 -LIN9 0.999926500458297 -H3F3A 0.692334633697484 -RP4-559A3.7 0.0163545947653949 -ITPKB 0.998850076050969 -TMEM63A 6.10813887296527e-05 -MRPL55 0.000411107916634712 -OBSCN 5.35738960908037e-91 -IBA57 0.0830210148136165 -TRIM11 0.547146512887441 -CDC42BPA 0.99992014796463 -PRSS38 0.0302666135927824 -ARF1 0.819433490606023 -GJC2 0.483282478985978 -JMJD4 1.86970802268343e-07 -GUK1 0.000100020035077034 -WNT3A 0.777794121014665 -HIST3H3 0.000822080676547451 -WNT9A 0.68038414960894 -SNAP47 0.00030482303703809 -ADCK3 1.23500239562904e-05 -TRIM17 2.40298559120734e-05 -C1orf145 0.097680709474626 -ZNF678 4.66546659354214e-07 -C1orf35 0.0740070368474459 -C1orf198 0.0273752757183558 -PGBD5 0.0280632434924286 -TAF5L 0.985849776766725 -AGT 1.57429487936421e-09 -SPHAR 0.0144631168350946 -HIST3H2A 0.484381729433831 -COG2 0.000167564985575961 -HIST3H2BB 0.0228263871923496 -URB2 3.33649047524477e-11 -RHOU 0.531957244266069 -CAPN9 1.73327533297539e-11 -NUP133 0.0662324196154904 -ABCB10 7.9478594059038e-06 -RAB4A 0.081107904343709 -TTC13 0.67322418180806 -ACTA1 0.00802663240582685 -CCSAP 0.11178307102521 -GALNT2 0.881985612838068 -KCNK1 0.580150979004335 -DISC1 0.0197098835616187 -NTPCR 1.70241673676366e-05 -IRF2BP2 0.470291318540817 -GNPAT 0.291272732702187 -MLK4 0.000607298684335364 -FAM89A 0.0096405423416975 -TSNAX 0.972037851150335 -TRIM67 0.672039658016629 -EGLN1 0.925890293932093 -MAP10 1.29356795750669e-14 -SLC35F3 0.894523108035515 -EXOC8 0.987113069402522 -SPRTN 0.981335747291668 -SIPA1L2 0.999219705697118 -COA6 0.0885473096033926 -ARV1 1.54945904545113e-06 -C1orf131 1.77283464318131e-07 -TARBP1 5.69518410914162e-16 -PCNXL2 7.55212281834843e-14 -TOMM20 0.577780758415904 -MTR 2.84377203137864e-07 -EDARADD 0.103567654975129 -HEATR1 0.999999993216506 -NID1 0.000366475613763869 -RYR2 0.999999934433848 -ERO1LB 1.54261289794237e-05 -LYST 0.999978422869173 -ZP4 3.78719861366908e-10 -ARID4B 0.999976459226573 -GGPS1 0.666629559092989 -GNG4 0.158455672191453 -ACTN2 0.999811915853309 -B3GALNT2 4.87048529360604e-06 -RBM34 7.9464873955861e-09 -MT1HL1 0.0200621262324532 -TBCE 6.2870662207293e-07 -LGALS8 0.000188797120394855 -GPR137B 0.000253029828140192 -CHRM3 0.937026128208817 -WDR64 4.9048627570315e-15 -FH 0.148694445276004 -C1orf101 5.88680638235274e-07 -OPN3 0.846289039558313 -FMN2 0.994502609230201 -MAP1LC3C 0.000381762122487153 -EXO1 9.25484656376633e-09 -C1orf100 3.53989017733453e-08 -GREM2 0.081742843165364 -SDCCAG8 1.32893386487215e-07 -AKT3 0.99958539864029 -ADSS 0.822870227739542 -ZBTB18 0.97012354907433 -CHML 0.0011577797146624 -KMO 0.000261678764903106 -PLD5 0.124197736898067 -RGS7 0.781745872893189 -CNST 0.925062821549835 -SCCPDH 0.0119007027684187 -DESI2 0.915084441052073 -ZNF124 1.29546905801823e-07 -KIF26B 0.999987955632678 -AHCTF1 0.999999999875185 -TFB2M 9.61899524222107e-05 -NLRP3 0.447262679111629 -C1orf229 0.520799629104626 -ZNF695 1.29535996261044e-10 -ZNF496 0.983327487660117 -ZNF670 0.451260083419079 -COX20 0.0118854356661511 -SMYD3 7.8037496651672e-06 -EFCAB2 7.50630911796469e-05 -HNRNPU 0.999903322582432 -OR2B11 0.0215165179641658 -OR2C3 0.114992646561768 -ZNF669 0.0604993991526988 -OR13G1 0.00566795772598196 -OR2AJ1 0.0152833137797469 -OR14A16 0.00599837462277144 -OR6F1 0.000152779476135538 -OR1C1 0.25334262466403 -OR2L3 6.39176609224206e-05 -OR14K1 0.00240709203730588 -OR2L13 0.0144191909265063 -OR2AK2 0.0159576976321787 -OR2G3 0.0570926577558068 -OR2W3 0.079635091424146 -GCSAML 0.0357958598740132 -OR2T8 0.71743769729565 -OR11L1 0.0194798581395402 -OR2G2 0.0571280420634526 -TRIM58 2.07666883202414e-07 -OR2L2 0.00186774816903584 -OR2L5 7.10964719988903e-05 -OR2L8 0.179168619944803 -OR2M4 0.000224877765407964 -OR2T29 0.476864535017878 -OR2T5 0.620583476697508 -OR14C36 0.0101800694540978 -OR2T33 0.0164922028007124 -OR2T2 0.692627480778694 -OR2M5 0.00156615505507947 -OR2T6 0.0505815474387303 -OR2T7 0.100403453856641 -OR2T10 0.000155748840698714 -OR2T34 0.746970217903766 -OR2G6 0.0097517007736297 -OR2T3 0.358715347130465 -OR2T12 0.0170417020619487 -OR2M3 0.0671997116609769 -OR2T4 0.337136812366449 -OR2T11 2.01105703156492e-05 -OR2M2 0.000216664687987796 -OR2T1 7.28824697455401e-07 -OR2M7 0.012356410379401 -SH3BP5L 0.140999405772345 -OR14I1 2.99510561937582e-05 -ZNF672 0.000127541106455286 -PGBD2 3.892421473741e-07 -ZNF692 3.97065824374004e-07 -OR2T27 0.000134198174502552 -OR2T35 0.536149911036962 -TPO 1.35596875602643e-07 -TMEM18 0.0536351493645142 -SOX11 0.343767037415361 -RSAD2 4.58535841046995e-12 -ADI1 0.00602945066661725 -FAM110C 8.70816981585542e-08 -MYT1L 0.999963989377009 -TRAPPC12 1.34328496197278e-09 -RNASEH1 0.0164156541621668 -PXDN 2.03602830062533e-05 -TSSC1 0.121031637073714 -RPS7 0.907087093194304 -SH3YL1 1.00024009653743e-05 -FAM150B 0.384937770733736 -SNTG2 9.17608832343845e-07 -CMPK2 0.00180796531822905 -ACP1 0.00220753415585866 -COLEC11 0.0720344752709555 -ALLC 4.60880908473295e-11 -TAF1B 4.28699121753238e-06 -ODC1 0.950802102507626 -RRM2 0.96827092119529 -ASAP2 0.99998604336681 -IAH1 0.000119134559107643 -CPSF3 3.4570475120286e-05 -C2orf48 0.0318183705555399 -CYS1 0.00331532008626381 -KLF11 0.00111669037367127 -ITGB1BP1 0.00190084865607946 -HPCAL1 0.779954229263187 -ID2 0.583638221851485 -RNF144A 0.988258456955496 -ADAM17 0.997367645320671 -MBOAT2 0.71697037979262 -GRHL1 0.983150778709021 -NOL10 0.80330394780875 -ATP6V1C2 2.2580233090132e-06 -KIDINS220 0.0290445776929918 -YWHAQ 0.873107724496422 -FAM84A 0.0878163030920847 -MYCN 0.913862107818068 -DDX1 0.998606607070136 -TRIB2 0.926787339017351 -PDIA6 0.120591091840199 -LPIN1 2.34821042560306e-05 -SMC6 0.455419790303775 -VSNL1 0.744967825012453 -RAD51AP2 1.70293206079099e-18 -GREB1 0.0254855377300684 -NTSR2 2.52586411261305e-05 -PQLC3 6.74909232375959e-07 -KCNF1 0.498369029988399 -ROCK2 0.999999990311408 -NBAS 1.89431039938141e-25 -E2F6 0.55450901223844 -C2orf50 0.00360224822906377 -FAM49A 0.805360676032756 -C2orf43 0.00064748477489379 -TTC32 0.0898978964968043 -NT5C1B-RDH14 5.06962994365991e-05 -SDC1 0.290469547271798 -APOB 5.49085163436995e-16 -WDR35 2.64838406754913e-16 -PUM2 0.999922863782349 -RHOB 0.245030976539202 -RDH14 0.232943493348579 -NT5C1B 3.45087072878803e-05 -GEN1 2.85815324965099e-10 -LAPTM4A 0.503802410255576 -GDF7 0.778067351749562 -KCNS3 0.0160901263314807 -OSR1 0.774760147238011 -MATN3 1.61181027463323e-06 -MSGN1 0.191097329641165 -HS1BP3 0.000353324886507251 -SF3B14 0.881404454908759 -C2orf44 0.0014413481942125 -PTRHD1 9.18016740847292e-06 -DNMT3A 7.7278751608327e-45 -NCOA1 0.999077342831501 -CENPO 6.62948080155535e-06 -DTNB 0.000530412146332964 -UBXN2A 0.000588703494775096 -ADCY3 0.00137930101469091 -FKBP1B 0.00888532712656979 -POMC 0.000689013181047222 -DNAJC27 0.0482582333406014 -ITSN2 0.0244336907969597 -TP53I3 3.7580421810693e-07 -PFN4 0.00113106337284472 -ATAD2B 0.999998682086859 -FAM228A 0.000409739893538017 -MFSD2B 1.76078145058686e-07 -EPT1 0.347461749547272 -SLC35F6 0.0161307579092324 -AC013449.1 0.174139213264941 -KIF3C 0.909864325651814 -C2orf70 0.000944694394683253 -DPYSL5 0.998332100766402 -CENPA 0.139975206060218 -ASXL2 0.992738818422806 -AGBL5 0.0206948513459665 -RAB10 0.944404791408518 -GPR113 1.48528745876047e-10 -HADHB 1.04714648529854e-07 -OTOF 4.32599885952291e-25 -CIB4 2.30345990608051e-06 -MAPRE3 0.799864407370243 -TMEM214 0.00116735534958103 -HADHA 0.0151113309974031 -DRC1 1.30453003302834e-10 -PREB 0.0018983627682706 -SLC5A6 0.571968337581082 -TCF23 0.000503312310069814 -ZNF513 0.940738428263313 -KHK 5.36079485314004e-05 -DNAJC5G 0.00397478941010456 -SNX17 0.686180301198043 -EIF2B4 0.832609528731968 -CAD 0.999999701880854 -UCN 0.517240162953561 -EMILIN1 0.00521656081419512 -ATRAID 0.00791394898030435 -MPV17 1.10286841801097e-08 -CGREF1 5.50290788195318e-08 -TRIM54 8.24707898322991e-07 -SLC30A3 0.64608387237045 -ABHD1 1.06027288753589e-21 -C2orf53 1.54927478958821e-09 -GTF3C2 0.999786435918561 -SLC4A1AP 7.73999085415032e-07 -GCKR 3.58392509874806e-16 -CCDC121 9.72713578876563e-05 -SUPT7L 0.833193338587633 -MRPL33 0.749164756585824 -PLB1 1.9931529274349e-56 -GPN1 0.0049035919998219 -NRBP1 0.999548511025196 -C2orf16 3.91661992667067e-17 -ZNF512 0.949146986047491 -FOSL2 0.925334261981773 -FNDC4 0.759219015798597 -PPP1CB 0.997194974203565 -RBKS 1.93197572918752e-05 -BRE 0.279976282823241 -SPDYA 0.166884223990281 -KRTCAP3 0.0445235342133754 -IFT172 2.29011817971014e-18 -PPM1G 0.996010385533881 -XDH 1.55760351242192e-13 -WDR43 0.998942440488972 -MEMO1 0.876156693867831 -EHD3 0.0885343960081059 -GALNT14 3.03253774344532e-09 -LBH 0.300590032052918 -FAM179A 2.53209738989517e-20 -SLC30A6 0.0126596121889265 -YPEL5 0.799401083937221 -DPY30 0.451358336289617 -LCLAT1 0.000175609752118781 -NLRC4 4.35115119359313e-08 -SPAST 0.99707471255289 -ALK 0.522362516846561 -C2orf71 5.64897460026644e-10 -CLIP4 0.000288887942474729 -YIPF4 0.019788591248373 -TRMT61B 4.00751770882134e-06 -CAPN13 1.83080779880556e-09 -SULT6B1 3.4792081587007e-11 -QPCT 1.87382648510695e-08 -CRIM1 0.977883078914308 -HEATR5B 8.10479286093348e-10 -EIF2AK2 0.0515534226933567 -PRKD3 0.00807565614889671 -STRN 0.969336393172942 -FAM98A 0.68941491445387 -TTC27 6.54258241947822e-09 -VIT 4.91295866698497e-22 -RASGRP3 0.110282852347241 -AC007390.5 0.346577578729861 -GPATCH11 1.26665642095237e-05 -LTBP1 0.526234698119928 -BIRC6 0.999999999999996 -FEZ2 3.59160198779228e-05 -NDUFAF7 1.17734908571096e-11 -CDC42EP3 0.275699032932777 -CEBPZ 1.78414032435548e-05 -RMDN2 5.20509387294093e-16 -EML4 0.391138665343134 -SRSF7 0.997841973267641 -SLC8A1 0.98820862479259 -COX7A2L 0.00041024940040515 -GALM 8.92598000417204e-09 -CYP1B1 0.00029647591103164 -DHX57 4.41862619399682e-08 -ATL2 0.980197371048562 -HNRNPLL 0.00539438758557714 -SOS1 0.99999989519361 -MAP4K3 0.804701046466324 -CDKL4 3.68817176201996e-08 -THUMPD2 1.94113855777167e-08 -GEMIN6 0.00259514571092877 -TMEM178A 0.95174771629757 -PKDCC 5.4125797267683e-05 -PLEKHH2 1.78874098604568e-26 -SIX3 0.348879193568557 -ABCG8 3.74527259993631e-16 -MTA3 0.855163471897877 -EPAS1 0.997628292931524 -DYNC2LI1 8.37968944079953e-05 -HAAO 7.80091656962148e-06 -ZFP36L2 0.456433762263267 -SRBD1 1.67463053962146e-14 -THADA 1.24008146143984e-28 -SLC3A1 7.54764121472888e-16 -KCNG3 0.0405974403481221 -OXER1 4.76881321179725e-07 -PPM1B 0.109620710824446 -SIX2 0.870283341963573 -ABCG5 1.89797083861304e-15 -CAMKMT 5.14965805552299e-13 -PREPL 2.42946176486827e-11 -PRKCE 0.999891646235438 -LRPPRC 0.000433777803620707 -FBXO11 0.999979628316394 -MSH2 0.867725630709854 -CALM2 0.856387218811605 -FOXN2 0.392770620749062 -EPCAM 7.50009447417055e-07 -C2orf61 0.0141003474837281 -ATP6V1E2 9.71403129278788e-05 -PIGF 0.000909040072288399 -KCNK12 0.671633264361772 -CRIPT 0.0186146204892108 -STON1-GTF2A1L 1.65449700249586e-14 -PPP1R21 0.000402100492101584 -RHOQ 0.304654917043609 -MCFD2 0.0699912352148666 -STON1 4.44985489455154e-08 -TTC7A 1.95620464496503e-09 -SOCS5 0.410273257241663 -PSME4 0.999999996860777 -LHCGR 2.80154457660207e-08 -ACYP2 0.000220644831166404 -GPR75 0.00319480233774598 -MTIF2 9.07160853775263e-08 -FSHR 3.74938916692834e-10 -SPTBN1 0.999999999947367 -ASB3 0.247642059161546 -GTF2A1L 5.65246891903056e-07 -ERLEC1 0.000679063416474332 -C2orf73 0.000860167631538041 -EML6 0.44303244895019 -CHAC2 0.00282189031328415 -CLHC1 4.15102363149147e-15 -TSPYL6 0.581660026360398 -CCDC88A 0.999999956100474 -RPS27A 0.525112781965164 -RTN4 0.0108353564169536 -GPR75-ASB3 0.247642059161546 -NRXN1 0.999948738356297 -CCT4 0.999184050209255 -COMMD1 0.372793786323877 -FANCL 2.09960326026736e-08 -PUS10 5.26981477460816e-10 -BCL11A 0.828999684744843 -REL 0.969516332676901 -PNPT1 0.90826684333985 -PEX13 0.0231397187071568 -AHSA2 5.61437783752719e-06 -VRK2 1.21621414925507e-08 -XPO1 0.999999567496659 -FAM161A 3.02772896806868e-09 -CCDC104 0.000457853241462737 -PAPOLG 0.989888395224926 -USP34 1 -SMEK2 0.811197027412435 -KIAA1841 3.32934655708566e-06 -EFEMP1 0.999786492859359 -CCDC85A 0.00173520517334067 -CEP68 0.371622601856965 -MEIS1 0.99088519686075 -VPS54 0.949816739802316 -PELI1 0.909074231450461 -ETAA1 0.975314596420393 -B3GNT2 0.696953713886218 -EHBP1 0.999748961950681 -UGP2 0.00102013070287478 -SPRED2 0.000973022757208799 -WDPCP 2.32411054871015e-09 -ACTR2 0.99709654108635 -RAB1A 0.602945640832257 -TMEM17 0.00402396190447031 -MDH1 0.982634617401256 -SLC1A4 0.242897704080993 -SERTAD2 0.736975237127184 -LGALSL 0.670765299027282 -C1D 0.365972886685355 -OTX1 0.219807903535165 -AFTPH 0.996888387523368 -BMP10 0.722716219511508 -PROKR1 5.42251256340407e-10 -ANTXR1 0.98528320310747 -APLF 1.13610489937719e-17 -FBXO48 0.0166653080454206 -ARHGAP25 0.438207321068152 -GFPT1 0.974567999344653 -GKN2 0.000143060405510152 -WDR92 0.805659459340733 -NFU1 0.000687750920306089 -PNO1 0.256534456542778 -CNRIP1 0.299559964908186 -ANXA4 0.000342406647441912 -MXD1 0.388108480553253 -PLEK 0.140273936864108 -AAK1 0.99932042127733 -GKN1 0.00026487819662883 -GMCL1 9.6231886938057e-06 -PPP3R1 0.889820219565523 -SNRNP27 0.024069445050423 -CD207 1.65311921220204e-06 -AC007040.11 0.000106767465979753 -MCEE 0.00211926018791901 -C2orf42 0.134381994203355 -TGFA 0.574368121554422 -MPHOSPH10 0.585921552769244 -TEX261 0.00019534179099528 -PCBP1 0.727131612150662 -CLEC4F 4.19038841935212e-12 -ADD2 0.999175206924775 -FAM136A 0.00147861672914258 -PCYOX1 6.73322799744091e-12 -ATP6V1B1 0.000244050365843846 -FIGLA 0.731738228189441 -VAX2 0.315038571131068 -TIA1 0.832581092063394 -SNRPG 0.866844385628649 -ANKRD53 0.000455607586717175 -NAGK 8.57690899485212e-09 -ASPRV1 0.0918052632340838 -C2orf78 6.9191452153743e-05 -FBXO41 0.95177320105102 -PRADC1 3.3061098634495e-07 -CCT7 0.989844502127012 -SFXN5 0.0140304509437934 -TPRKB 0.0206180267045899 -ZNF638 0.999959949685778 -CYP26B1 0.954353506649453 -EMX1 0.710215196701832 -SPR 0.000439257239321401 -SMYD5 0.103327058155762 -EXOC6B 0.666298051678121 -ALMS1 3.0369217543731e-39 -DUSP11 9.06000699119451e-05 -PAIP2B 0.0917531004004723 -RAB11FIP5 0.00267591631179698 -NAT8 0.0756516923219644 -EGR4 0.0062667783643699 -DYSF 1.00255104624413e-15 -TTC31 2.61841974324849e-15 -DCTN1 0.291891035522283 -WDR54 2.39788118448388e-06 -MOB1A 0.853010254514718 -ACTG2 0.692010864371864 -LBX2 0.617324061969185 -DGUOK 0.368434604695276 -STAMBP 0.00143027314024062 -TET3 0.999942650512804 -BOLA3 0.418296316493259 -MRPL53 0.222249430173565 -WBP1 0.000303097285548392 -RTKN 0.000149538066738097 -CCDC142 0.000167047986406049 -SLC4A5 1.37460263086747e-07 -MOGS 3.25166586108679e-09 -MTHFD2 0.151202634179126 -INO80B 0.949554116037684 -GCFC2 6.26945536555853e-12 -PCGF1 0.987060430814222 -TACR1 0.000227888560237543 -REG3A 0.00142860711460032 -AUP1 0.0241550475219776 -REG3G 2.17515516666175e-05 -M1AP 5.83274913656993e-12 -DQX1 7.46878481629986e-15 -SEMA4F 6.7352998574131e-10 -HK2 0.0209328439585101 -MRPL19 0.00131859090035099 -REG1A 0.00852762762703895 -DOK1 0.0169928839616036 -HTRA2 0.00230127577366885 -LOXL3 5.65366567269509e-08 -REG1B 0.00195416709048902 -TLX2 0.140777838183909 -EVA1A 0.0618110308718402 -LRRTM4 0.748069164341842 -POLE4 0.000410965033929284 -TMSB10 0.124315434010793 -CTNNA2 0.999717952847311 -SH2D6 0.00369649800986005 -LRRTM1 0.951075572630596 -TMEM150A 0.145714083697218 -DNAH6 0.000223494727431832 -CAPG 5.32548826021192e-09 -C2orf68 0.0124864992399887 -KCMF1 0.595292976154389 -VAMP8 0.270489594281997 -RETSAT 2.04966693109555e-10 -TGOLN2 0.000179690886067026 -VAMP5 0.0516197457018348 -MAT2A 0.733230032010008 -TRABD2A 7.93859484463642e-10 -ELMOD3 4.56408780285543e-11 -RNF181 3.13991934782278e-09 -GGCX 1.19797696730827e-08 -SUCLG1 0.0597686458354184 -TCF7L1 0.753752010042604 -IMMT 0.000945647236388923 -RNF103 0.832672501332977 -RMND5A 0.964712069198993 -RNF103-CHMP3 0.036245866120423 -SFTPB 0.040741578571877 -POLR1A 0.999861745940553 -ATOH8 0.888203282317987 -KDM3A 0.981756840004812 -ST3GAL5 0.0278549097052091 -PTCD3 1.02555530600256e-06 -REEP1 0.938706616254476 -CD8B 0.412381162991474 -MRPL35 0.0209370095571054 -GNLY 0.00154995699769898 -CHMP3 0.036245866120423 -USP39 0.0316077960336367 -CD8A 0.0241810989781012 -THNSL2 3.94167649325955e-06 -MAL 0.78607902501438 -ASTL 3.67008336651582e-05 -TEX37 3.7065751974129e-06 -ZNF514 7.04681464876894e-09 -FAHD2A 0.0540720339307648 -SMYD1 0.000247889682244781 -ZNF2 0.298104856888565 -PROM2 7.89703407792325e-08 -KCNIP3 0.852600760709297 -RPIA 0.00590911291307371 -EIF2AK3 0.0114235489498432 -ADRA2B 0.000244368543397983 -KRCC1 0.187811675472145 -MRPS5 0.0063387043052427 -TRIM43 0.484034992740452 -TEKT4 2.56100307685227e-11 -FABP1 0.0160619800486128 -GPAT2 0.0016122998449236 -KANSL3 0.994530636900608 -FAM178B 8.69889482161504e-05 -ACTR1B 0.0316601262849816 -FAHD2B 0.0279113840334889 -NCAPH 0.0321635838191526 -CNNM4 0.000338908702685108 -ANKRD36 2.11660484589104e-19 -SNRNP200 0.999999999999148 -COX5B 0.412576836067639 -ANKRD23 8.66315090908555e-16 -LMAN2L 1.28590577344366e-07 -TMEM127 0.101457374227938 -ARID5A 0.971125743700561 -STARD7 0.927709615692812 -ANKRD39 0.0573082907278283 -CIAO1 0.0147161304906565 -DUSP2 0.791321031693344 -ITPRIPL1 1.10905298650302e-07 -SEMA4C 0.999373139159557 -MGAT4A 0.0598161748111026 -TXNDC9 0.223930350936401 -INPP4A 0.99488626390091 -C2ORF15 0.013119592808789 -EIF5B 0.895387512560445 -TSGA10 0.894352624053566 -MRPL30 0.543252452898348 -COA5 0.239646156062635 -UNC50 0.0116183072135509 -VWA3B 3.26524146038958e-18 -LYG2 5.77012180169849e-06 -TMEM131 0.999999482162299 -CNGA3 1.18045078044952e-08 -ZAP70 0.272667248493713 -LYG1 0.000104427732291753 -C2orf15 0.543252452898348 -MITD1 0.00170794026951473 -LIPT1 6.17016770936916e-05 -IL1RL1 1.28060324751977e-07 -IL1R2 1.95242791720407e-07 -RPL31 0.843001842538011 -LONRF2 0.851045048927734 -AFF3 0.998912591236449 -CNOT11 0.993507645349384 -IL1RL2 1.96903985630201e-07 -RFX8 0.379276472235567 -REV1 0.997023540664416 -PDCL3 0.000392970999859276 -CREG2 0.00561130743800167 -TBC1D8 5.26132710714781e-07 -IL1R1 0.362921430952917 -CHST10 0.00330306267127204 -RNF149 0.000502223698926861 -AC012493.2 0.395880595507613 -NMS 2.78112452887771e-10 -MAP4K4 0.999998979047087 -NPAS2 0.990888561613575 -NCK2 0.702843117670504 -UXS1 0.0661553399099762 -C2orf49 0.192673532038566 -MFSD9 7.72060377762361e-06 -GPR45 0.864764500756331 -IL18R1 5.02097661201518e-07 -TGFBRAP1 0.129423465806074 -TMEM182 0.0159876948837043 -IL18RAP 0.366507424726522 -SULT1C3 2.998783895639e-11 -MRPS9 3.35947244572882e-06 -C2orf40 0.00167864098073389 -SLC5A7 0.101652706275807 -FHL2 0.00288060194827599 -ST6GAL2 0.0149364382080836 -SLC9A4 1.58073058570014e-06 -SLC9A2 0.481161337483386 -ACOXL 6.28385483611373e-10 -RANBP2 0.999999998507193 -SULT1C2 1.42167398484664e-05 -BCL2L11 0.950822922206983 -CCDC138 1.08334074018145e-05 -MALL 0.201463447177582 -NPHP1 1.36518515099961e-08 -LIMS1 0.347565207480817 -BUB1 4.49651698196957e-06 -EDAR 8.30571010658446e-05 -SEPT10 0.00288328636526247 -SULT1C4 0.000445387423842765 -RGPD6 0.401313700854421 -SH3RF3 0.981100871728341 -GCC2 0.0134657614610954 -CKAP2L 0.218393604055394 -POLR1B 0.91220791018127 -SLC20A1 0.725656582615843 -CHCHD5 0.0336410132342975 -IL1A 1.1235918506998e-05 -IL36A 0.000123309813533248 -ZC3H6 0.938245509196475 -IL1B 0.925868311820487 -MERTK 9.66187266673099e-08 -IL36G 2.50412730985725e-05 -IL1F10 0.0039602428583005 -TTL 0.984657698728457 -TMEM87B 7.97639690780215e-08 -FBLN7 1.57848110307796e-05 -IL36B 0.00351729714336239 -IL36RN 0.000972339640244069 -IL37 0.00783605765988603 -ZC3H8 0.464854053485364 -STEAP3 3.93787753538719e-07 -ACTR3 0.998335663589052 -DBI 0.000164260337073615 -DDX18 0.839996435028735 -CBWD2 0.967070795623724 -PSD4 0.805496070283155 -TMEM37 0.0418161454815406 -IL1RN 0.340218948927042 -RABL2A 0.940339177673539 -SCTR 1.95522328385349e-09 -MARCO 6.41628014969988e-08 -C2orf76 0.00333205633699219 -INSIG2 0.023277147220178 -SLC35F5 0.00121571774591936 -DPP10 0.99998928551057 -C1QL2 0.396068457162213 -PAX8 0.90212384293593 -CCDC93 0.064375261486792 -EN1 0.751931859883325 -ERCC3 2.05509479327392e-05 -MKI67IP 0.000174106402560633 -MAP3K2 0.999560916816359 -RALB 0.193989190711601 -PTPN4 0.999997516004175 -GYPC 0.0138697690065761 -CLASP1 0.999999988870922 -TFCP2L1 0.999192586615908 -CYP27C1 0.000184566831654872 -INHBB 0.916829217955213 -TMEM177 0.428469415988159 -CNTNAP5 0.0972729242803616 -PCDP1 6.22961816607344e-09 -TSN 0.945966337540149 -EPB41L5 0.0229338405829811 -TMEM185B 0.493451137380388 -GLI2 0.998939595969048 -BIN1 0.474193121768888 -MYO7B 6.3829496749846e-16 -HS6ST1 0.906059214439201 -WDR33 0.999997732823828 -TUBA3E 0.00120527821375768 -AMMECR1L 0.995586601652785 -LIMS2 1.13990016377388e-05 -SAP130 0.998572964181711 -PROC 0.0324754428971477 -CCDC74B 1.19190170799534e-06 -SMPD4 0.00605804578247869 -IMP4 0.000968217902139582 -UGGT1 0.00289726281334611 -RAB6C 0.377324685045267 -MZT2B 0.575112152377793 -IWS1 0.986444880095647 -CCDC115 1.51132252418088e-05 -GPR17 1.06559378636528e-05 -POLR2D 0.470737784692657 -CCDC74A 1.16806309975737e-05 -TUBA3D 3.70763769526702e-08 -MZT2A 0.0055676765947401 -CFC1 0.682601111382939 -PLEKHB2 3.5372142088758e-06 -FAM168B 0.0437714936797545 -GPR39 1.54608229502499e-12 -ARHGEF4 0.0685948768686647 -C2orf27B 0.0140708907504597 -C2orf27A 0.419684826011534 -AMER3 0.000112022874748601 -PTPN18 6.51922683029034e-07 -GPR148 0.00480951704813308 -LCT 0.0642550168201587 -HNMT 0.0967293826850996 -NXPH2 0.798014407186903 -NCKAP5 0.524874191725049 -ACMSD 1.98871537094846e-07 -THSD7B 5.65285413355626e-06 -LYPD1 0.000238591129314029 -UBXN4 0.974205695161288 -SPOPL 0.0454469525997792 -DARS 0.00061199920887983 -ZRANB3 7.42639986547535e-15 -R3HDM1 0.00602513988409452 -RAB3GAP1 3.66101381631237e-05 -MAP3K19 3.69884742626308e-14 -CXCR4 0.427450979947767 -TMEM163 0.0672624651374226 -MCM6 0.998482019514362 -MGAT5 0.999925016569622 -CCNT2 0.49810408150126 -ACVR2A 0.993932261799491 -MMADHC 0.02077684339759 -NEB 4.08103130095905e-17 -KYNU 1.82768855736828e-09 -NMI 6.22629202890385e-09 -EPC2 0.999952360459163 -LYPD6 0.000624825868659602 -KIF5C 0.999515597151875 -RBM43 0.0518667699188216 -TNFAIP6 4.01524767427486e-06 -ZEB2 0.999833866722983 -ORC4 2.29195436096199e-06 -RND3 0.940812851099585 -GTDC1 2.40902542593717e-10 -LRP1B 0.999999190192507 -LYPD6B 0.00103350797846491 -MBD5 0.999852333253027 -RIF1 0.999999997436204 -ARHGAP15 5.25405675416054e-06 -NR4A2 0.991432865508232 -CYTIP 0.0487986718847789 -GALNT13 0.853952804016347 -RPRM 0.532566514880165 -GPD2 0.000100774785789542 -ACVR1 0.95644819340706 -DAPL1 0.000268262509293928 -UPP2 0.00202492321799246 -FMNL2 0.996999397171698 -CACNB4 0.0113635817076805 -ERMN 0.00310152547649555 -PKP4 1.59819832523135e-05 -KCNJ3 0.989708242851416 -CCDC148 7.95012569570602e-19 -ACVR1C 0.0448910050879584 -STAM2 0.034504985570748 -ARL5A 0.0173648434841349 -ARL6IP6 0.170955560789642 -GALNT5 1.33613590422636e-12 -PRPF40A 0.966325783136999 -IFIH1 6.00238931195841e-26 -DPP4 4.05740539448844e-10 -SLC4A10 0.00263554372615494 -CD302 0.0093852868835867 -MARCH7 0.977026371329949 -GCG 0.0772034616847316 -PSMD14 0.790099057421391 -TBR1 0.993588037464593 -GCA 0.000445654786146001 -PLA2R1 5.17711186126812e-15 -LY75 3.63213139501385e-27 -ITGB6 1.90571778312696e-15 -TANC1 0.140685896305883 -LY75-CD302 3.63213139501385e-27 -KCNH7 0.984445949327848 -BAZ2B 0.999921440363501 -FAP 3.27312070401378e-11 -WDSUB1 1.37628007456398e-06 -RBMS1 0.996886207084215 -TANK 0.943798417923446 -NOSTRIN 3.5797265988291e-10 -CSRNP3 0.832452929930476 -SCN7A 1.72076245416042e-15 -COBLL1 0.0121973641922403 -XIRP2 2.85559362075031e-37 -GALNT3 2.0116310885668e-05 -G6PC2 1.91255841634904e-09 -SPC25 0.0594294501038599 -FIGN 0.741736097596996 -SCN1A 0.999999999535395 -SLC38A11 1.9255130084062e-06 -TTC21B 3.38768007245796e-22 -SCN3A 0.999999992847256 -STK39 0.999462431417641 -SCN9A 9.30185484244833e-13 -CERS6 0.684541332373748 -GRB14 0.0966012167550771 -B3GALT1 0.329724363511517 -ABCB11 2.18849485467569e-10 -SCN2A 0.999999992314383 -CCDC173 1.08459309632037e-15 -SP5 0.432721441198873 -MYO3B 4.47146671165632e-20 -KLHL41 0.0188120404902001 -GAD1 0.82254015260978 -METTL5 0.00367271509116605 -PPIG 0.984147328507764 -RP11-724O16.1 0.00439597445972593 -KLHL23 0.0206607984994721 -TLK1 0.999994767519327 -SSB 0.525946313253719 -BBS5 0.00259936459879345 -DHRS9 2.60804336160151e-07 -PHOSPHO2 0.0155246829335628 -GORASP2 0.891064439802649 -FASTKD1 1.65436401216165e-12 -LRP2 0.99999999999851 -UBR3 0.999549123627985 -RAPGEF4 0.957225849602447 -CDCA7 0.141954502881666 -METTL8 1.43717079201752e-09 -DLX2 0.887610614037221 -SLC25A12 0.887050481777341 -ITGA6 0.00991360284214048 -SCRN3 1.32015222635661e-06 -MLTK 1.21040586417153e-06 -PDK1 0.00465668929433836 -DCAF17 0.000284984948941262 -CYBRD1 0.351788246409073 -METAP1D 1.55557888019336e-06 -OLA1 0.0436206997457236 -DLX1 0.926719407831698 -SP9 0.498147938263282 -DYNC1I2 5.18719626749822e-07 -AC018470.1 0.0207446505030933 -HAT1 0.839884792256617 -CIR1 0.0121190516591458 -SP3 0.992297744064531 -HOXD3 0.407559214082803 -HOXD4 0.167399010627391 -GPR155 8.12952100257327e-11 -WIPF1 0.944313925016733 -CHN1 0.837424430279943 -HOXD12 0.00334591723055039 -HOXD10 0.132556118191002 -NFE2L2 0.686008361900756 -HOXD1 0.0105884596930334 -KIAA1715 0.00192358301419587 -HNRNPA3 0.992644939735303 -HOXD8 0.617630962362728 -CHRNA1 8.79556820389947e-06 -HOXD13 0.33206948542304 -MTX2 0.0813718081793007 -ATP5G3 0.538092564469556 -HOXD9 0.422099307773999 -HOXD11 0.0131898476206074 -ATF2 0.89224439257863 -CCDC141 1.4276211576785e-09 -DFNB59 1.07044413650742e-05 -PLEKHA3 0.0229786985598172 -TTN 1.21111377105808e-32 -UBE2E3 0.653907525579768 -ZNF385B 0.00106530263678159 -PDE11A 4.16725018760818e-31 -NEUROD1 0.138071318356774 -SSFA2 7.68386262291993e-05 -SESTD1 0.989112552502484 -ITGA4 0.0288517021361378 -RBM45 0.000125349305556292 -CERKL 5.39719665583234e-11 -PRKRA 0.15454198723567 -OSBPL6 0.999012303789089 -FKBP7 3.15602385489856e-05 -CWC22 0.0181890738297984 -AGPS 0.998805101972043 -TTC30B 0.00186185059553787 -TTC30A 1.362196147394e-05 -FSIP2 3.21632919900929e-08 -CALCRL 0.926324873613011 -DIRC1 0.0222588439435162 -ITGAV 0.477866430207163 -COL5A2 0.999999999884353 -DUSP19 0.00439399968226496 -DNAJC10 8.94919335579899e-05 -ZC3H15 0.947515648259226 -NCKAP1 0.999999990714008 -FRZB 0.125665908311615 -FAM171B 0.0574213565538764 -ZSWIM2 5.13768966981789e-10 -COL3A1 0.999999998393609 -PPP1R1C 0.00253358869301562 -AC018867.2 0.381213095192818 -NUP35 0.123687364628472 -TFPI 0.0253229555895134 -GULP1 0.677557750178314 -PDE1A 0.730656355381448 -ZNF804A 0.827436291073838 -STAT4 0.988867842653571 -PMS1 6.56457792406353e-14 -ASNSD1 1.63756463401646e-08 -SLC40A1 0.977595134539298 -ORMDL1 0.0758238996219523 -GLS 0.999302599696976 -MYO1B 0.878004107551654 -OSGEPL1 0.000202433816403507 -NAB1 0.84850840841026 -NABP1 0.014256968227511 -MSTN 0.812914735546533 -STAT1 0.999994277113306 -INPP1 0.000237351689203819 -SDPR 0.000704632748926169 -ANKAR 6.6124241759396e-24 -HIBCH 4.18223751191075e-08 -C2orf88 0.023588526845881 -MFSD6 0.00184669369540055 -WDR75 0.566494633877436 -C2orf66 0.00454708436823975 -CCDC150 3.80375071750666e-24 -SF3B1 0.999999972774106 -HSPD1 0.985208243840261 -BOLL 0.00790218351286136 -SLC39A10 0.997850639903884 -HSPE1-MOB4 0.889798357973135 -PGAP1 0.00878588184543819 -HECW2 0.99999585183338 -RFTN2 0.00207696217684847 -MARS2 1.41647403486977e-06 -TMEFF2 0.386319161722515 -ANKRD44 0.775902811645404 -GTF3C3 5.35810483574069e-06 -AC011997.1 0.00485703460001062 -STK17B 0.0898257461867161 -MOB4 0.777832909994367 -DNAH7 1.0373966005542e-47 -HSPE1 0.787528047849985 -COQ10B 0.140032716980132 -CLK1 0.0953474554277548 -ORC2 0.971869811180841 -NDUFB3 0.0425652843014725 -CASP10 8.53789597425533e-12 -C2orf47 0.00977968048221656 -KCTD18 0.000526111235034034 -TYW5 2.19729035112119e-07 -FAM126B 0.979818816441785 -PLCL1 0.0110523707623017 -CFLAR 0.999719869699545 -PPIL3 0.549646605195737 -CASP8 0.00484502421758434 -SGOL2 6.60739694811965e-05 -BZW1 0.744805846771698 -C2orf69 0.432171539151161 -SATB2 0.99956300698079 -NIF3L1 0.00517700548052124 -AOX1 2.67936726161947e-22 -SPATS2L 0.970345371568033 -CDK15 5.05622865918498e-13 -ICA1L 0.442027586412226 -MPP4 5.87636433014139e-09 -ALS2CR11 7.66191254911719e-11 -TRAK2 6.92274497111198e-10 -CYP20A1 7.40838062967993e-10 -TMEM237 9.39702047725716e-10 -STRADB 0.669632058274396 -ALS2CR12 1.66284147135039e-10 -ALS2 0.000769641354733604 -NBEAL1 1.09294225815105e-10 -BMPR2 0.996668086457278 -CARF 0.00454103717523082 -SUMO1 0.80037401914066 -FAM117B 0.0673870151606627 -NOP58 0.509478886469782 -WDR12 0.609006890639148 -FZD7 0.73019872989797 -ADAM23 0.995404041331662 -CPO 1.82892275396605e-13 -MDH1B 5.81111250194294e-12 -KLF7 0.92993070889515 -ZDBF2 1.3787431893894e-07 -PARD3B 8.64518813873327e-08 -CTLA4 0.57732241884153 -CD28 0.511989197368705 -GPR1 1.8355531462035e-05 -DYTN 2.804133893579e-15 -FASTKD2 4.03134120797395e-06 -INO80D 0.99817951445727 -RAPH1 0.957851233210029 -NDUFS1 3.9665516500916e-09 -ABI2 0.953329215745317 -ICOS 0.0520092290924777 -CREB1 0.969960676573643 -NRP2 0.0017116502518865 -EEF1B2 0.333347471841196 -MYL1 0.0633863743158515 -RPE 0.316665036809444 -CRYGD 0.00822648074513727 -KANSL1L 0.476930027111924 -CRYGB 2.05606816353459e-09 -MAP2 0.999983364970244 -C2orf80 7.49151434788534e-05 -CCNYL1 0.977770143814808 -METTL21A 0.0521776538764983 -ACADL 3.5917982569485e-08 -PTH2R 1.3161518374435e-15 -CPS1 0.0833573677195577 -CRYGA 0.000127117288397655 -LANCL1 9.92097579258599e-06 -PIKFYVE 0.97980274888433 -IDH1 0.00145370762541468 -CRYGC 0.0436098458397775 -PLEKHM3 0.76624837589687 -FZD5 0.898345425581581 -UNC80 0.139839110565612 -IGFBP2 0.84435378457342 -ERBB4 0.999900653614005 -ATIC 2.48609470825841e-13 -XRCC5 0.999991832000583 -PECR 0.000786066276789855 -BARD1 1.17553778280862e-11 -SPAG16 3.65639735304229e-20 -IGFBP5 0.859978350463281 -TNP1 0.222164609123562 -SMARCAL1 0.000314358585842015 -VWC2L 0.612117520612058 -RPL37A 0.00477076544447004 -IKZF2 0.922956763628976 -FN1 0.0644415382988527 -MREG 5.96360913088242e-06 -ABCA12 2.02270864482359e-07 -TMEM169 0.0117845367387348 -MARCH4 0.0162584104874255 -ARPC2 0.990984291645615 -CXCR1 0.000374556416932971 -C2orf62 6.71096173645635e-05 -USP37 0.998322478621928 -CXCR2 0.405284397129407 -GPBAR1 1.86484038880538e-06 -RQCD1 0.930277945404411 -CTDSP1 0.902026975894043 -TMBIM1 7.40053901450362e-05 -RUFY4 4.87589210961602e-09 -AAMP 0.531201269396819 -TNS1 0.924939888851989 -VIL1 1.21278222497287e-05 -PNKD 1.89916080841465e-08 -STK36 3.75253893187074e-07 -ZNF142 1.87523307695819e-15 -BCS1L 2.2774208943895e-08 -RNF25 0.829695265718338 -SLC11A1 6.5921175084613e-12 -PLCD4 8.11639260444202e-09 -ATG9A 0.714827712943686 -CNPPD1 1.63494195830923e-05 -CRYBA2 0.000626081708704005 -GLB1L 2.51566098661046e-10 -WNT6 0.669265997304332 -ZFAND2B 0.00495151493335169 -ABCB6 2.11132200307841e-17 -ANKZF1 4.83243050013918e-14 -CCDC108 2.33292401855033e-18 -FAM134A 0.758589563138407 -IHH 0.349924208747533 -SLC23A3 0.00231261775618616 -STK16 0.000478667136022908 -TTLL4 2.83171379258391e-06 -NHEJ1 0.027184525357164 -WNT10A 0.0101692886252667 -CYP27A1 3.89681875061633e-11 -PRKAG3 9.66992545866806e-05 -GMPPA 2.35237377979873e-06 -PTPRN 0.021748200630743 -ASIC4 0.72851478269818 -DNPEP 0.000202595534805018 -CHPF 0.231251265748001 -EPHA4 0.99989132522117 -PAX3 0.900856133271901 -DES 0.00308243386387878 -SPEG 0.999790421916053 -MOGAT1 2.12658352177613e-06 -SLC4A3 0.218420219942613 -SGPP2 0.0122737609427454 -TMEM198 0.061248392613131 -CCDC140 0.0630857519946017 -INHA 0.199710681546667 -OBSL1 6.64137887872857e-16 -DNAJB2 5.19696073671681e-06 -FARSB 0.900979753771666 -TUBA4A 0.0296379358390164 -FAM124B 0.00229940234451662 -TM4SF20 2.18814392829867e-06 -C2orf83 0.0501106068636758 -KCNE4 0.560426843330162 -SERPINE2 0.643023919378065 -SLC19A3 0.00163108657525026 -NYAP2 0.906196258132315 -IRS1 0.218507352371316 -RHBDD1 4.74167775070528e-09 -AP1S3 0.167450176735496 -CUL3 0.974063405438851 -AGFG1 0.969265961919115 -WDFY1 1.68817254810104e-05 -SCG2 0.898323134283839 -COL4A4 1.68977859995688e-08 -ACSL3 0.530102680564255 -COL4A3 7.57550007722727e-05 -MRPL44 9.27743859396845e-06 -MFF 0.375813389382855 -DOCK10 0.0291925300959096 -DAW1 0.00078594792223416 -SP140L 6.06952429760381e-05 -GPR55 0.000388569399865933 -ARMC9 1.03024252062501e-08 -SP140 1.99687363350876e-08 -PID1 0.403719374100703 -ITM2C 0.208530379146834 -TRIP12 0.999999999999483 -FBXO36 3.22841418359222e-06 -CAB39 0.0621795964046071 -HTR2B 3.66015293333563e-09 -PSMD1 0.999999202638138 -SP110 3.16369314039825e-09 -SLC16A14 0.215983363626467 -DNER 0.785502089513872 -SPHKAP 0.233358014706211 -SP100 8.71376355676682e-07 -CCL20 0.0877400024034262 -DIS3L2 0.863517182071107 -EIF4E2 0.91955877975189 -EFHD1 0.77000556440612 -ALPP 1.68537812798331e-06 -NCL 0.999106738363181 -COPS7B 0.207502332172099 -PTMA 0.377491925621091 -ALPI 4.02971384353915e-16 -CHRND 7.26421538921512e-07 -NPPC 0.32306534692621 -NMUR1 1.07262381171516e-05 -PDE6D 0.0844960932718429 -CHRNG 1.12925757682932e-09 -ALPPL2 6.22052907362555e-06 -B3GNT7 0.620845260079446 -ECEL1 9.10967319793021e-05 -C2orf57 0.00229596523789253 -KCNJ13 0.758052442479994 -AC106876.2 0.322632813017622 -C2orf82 0.466831048732835 -UGT1A7 1.8013984282508e-12 -UGT1A9 1.32215694425957e-08 -INPP5D 0.167430840933568 -UGT1A8 6.95565246350873e-05 -UGT1A10 1.09144321714604e-11 -UGT1A1 2.93632324623578e-09 -DGKD 0.97707055456914 -SAG 1.56803495288471e-08 -UGT1A6 0.000217879588051916 -GIGYF2 0.99999999997935 -UGT1A3 2.93632324623578e-09 -UGT1A4 2.34298507765321e-06 -NEU2 3.08678522547744e-12 -UGT1A5 0.000100214943072604 -NGEF 0.949825524634906 -USP40 1.74474759846129e-14 -ATG16L1 0.999737382504978 -GBX2 0.567961292707506 -RBM44 0.0141498802590379 -COL6A3 7.79330849282056e-11 -IQCA1 0.00138117063159793 -LRRFIP1 0.365512490408218 -RAB17 0.00739028017956446 -SPP2 1.27136183221359e-06 -HJURP 1.26222310392964e-05 -ARL4C 0.607389355262414 -MLPH 0.00125354964830075 -AGAP1 0.999356435740804 -TRPM8 4.73679846782498e-15 -MROH2A 0.314233041801318 -ACKR3 0.419555701616577 -COPS8 0.138824250988609 -ASB18 0.00457337421001374 -SH3BP4 0.0809644359581152 -PRLH 0.0401709303704193 -KLHL30 8.29725101843079e-11 -OR6B3 0.0646108476974636 -SCLY 1.52191274633036e-06 -NDUFA10 0.00138793990464123 -HES6 0.00886156439200741 -TWIST2 0.443476734119021 -PRR21 0.00365275248209853 -HDAC4 0.999989726820827 -ILKAP 0.99250779685517 -ESPNL 3.87784946442822e-10 -TRAF3IP1 0.000159261765651607 -UBE2F 0.950479184702081 -ASB1 0.350835778789251 -OR6B2 0.695947064753924 -PER2 0.933004687040542 -RAMP1 0.0577928242238866 -AQP12B 0.00435864786698477 -GPC1 0.109569938244377 -PASK 9.06471768179714e-20 -HDLBP 0.999998382970679 -PPP1R7 0.840144247050338 -AQP12A 0.0462663637441815 -SNED1 0.983762810114589 -GPR35 0.00363558120757164 -MTERFD2 0.00488812041925451 -OTOS 2.78890336245965e-07 -CAPN10 2.37881013810975e-08 -KIF1A 0.99998943706213 -RNPEPL1 0.0279016170372594 -AGXT 0.00359436899475076 -DUSP28 0.23221694539441 -C2orf54 6.76852841899048e-06 -ANO7 1.87089456161351e-30 -MYEOV2 0.000104799265064917 -ANKMY1 7.81266990643975e-14 -CXXC11 2.88586379912503e-05 -GAL3ST2 4.41529604975779e-05 -BOK 0.318891848354031 -NEU4 0.00027758289159766 -SEPT2 0.866554502924365 -THAP4 0.116840641035292 -ING5 0.445393628361777 -ATG4B 0.988495912592781 -FARP2 1.9753652138302e-20 -DTYMK 0.54609142720961 -PDCD1 0.0179540479322239 -STK25 0.0452670903034573 -D2HGDH 0.000752024031447155 -CRBN 0.0384944384873777 -GRM7 0.999169068679813 -OXTR 5.74322739893592e-05 -BHLHE40 0.941607017631946 -CNTN6 3.58671135173889e-22 -IL5RA 0.000332264657278137 -LMCD1 0.376043791136965 -CAV3 0.339836385676367 -ARL8B 0.622356589003264 -SUMF1 0.0425777224004311 -SETMAR 0.00213127902514751 -EDEM1 5.59576418489089e-11 -CHL1 2.05381563644969e-06 -SSUH2 2.48997802703819e-08 -LRRN1 0.876589036506927 -CNTN4 0.996606387924368 -ITPR1 0.999999999994095 -AC018816.3 0.391940522738083 -TRNT1 2.45863122935093e-06 -RAD18 5.20372835528497e-05 -OGG1 7.80168038151753e-08 -CIDEC 0.00141663238797231 -IL17RE 0.00861987839064516 -CRELD1 1.4147073999886e-06 -PRRT3 0.658018522445195 -CAMK1 0.00474654619158076 -JAGN1 0.0230627329552788 -CPNE9 0.0010321031792749 -THUMPD3 3.99618097660492e-11 -SRGAP3 0.999997750223865 -ARPC4-TTLL3 1.37468731036407e-12 -TTLL3 3.84160687240076e-14 -LHFPL4 0.178387581231495 -RPUSD3 0.0003227735750223 -BRPF1 0.999626031304734 -ARPC4 0.937798821155646 -MTMR14 0.00293982096906861 -IL17RC 4.25361992744768e-10 -TADA3 0.0047473552883576 -SETD5 0.999999563778174 -FANCD2OS 0.0484543148164917 -HRH1 0.00156116787120129 -BRK1 0.604508693799594 -TATDN2 0.000742651150073241 -GHRL 8.36902634828911e-05 -SEC13 0.584365053119917 -ATG7 1.52666137074291e-05 -SLC6A11 0.364943330068891 -TIMP4 0.00355403121695193 -ATP2B2 0.999921506473264 -FANCD2 2.47937339463725e-14 -SLC6A1 0.999301879165817 -TSEN2 0.000104861288702718 -EMC3 0.801934562245368 -TAMM41 0.000184600184419332 -VHL 0.0337352004297955 -PPARG 0.668218173785609 -IRAK2 2.89785862103042e-08 -VGLL4 0.469478552740923 -CCDC174 2.94812141217999e-05 -C3orf20 2.35749782524757e-14 -RAF1 0.999776866110749 -TMEM43 9.84762662149707e-08 -MKRN2 0.407628906147087 -NUP210 1.45347383950117e-10 -LSM3 2.76631880023763e-05 -CHCHD4 0.144674862711758 -XPC 1.31713341793089e-10 -HDAC11 0.0447802083550292 -FBLN2 0.62982515300036 -IQSEC1 0.998506226942054 -CAND2 4.5328114836349e-09 -FGD5 0.994386979064628 -NR2C2 0.994140346353249 -WNT7A 0.441260494800712 -SLC6A6 0.98227564953919 -RPL32 0.755582037585297 -TMEM40 0.000135844028608561 -ANKRD28 0.99992881046712 -EAF1 0.070565049762035 -SATB1 0.856613872020163 -GALNT15 5.51634648613177e-10 -METTL6 0.000603417643377884 -EFHB 6.02556402227351e-17 -COLQ 1.42517319859713e-07 -OXNAD1 2.37384753438508e-05 -SH3BP5 0.00902325002023801 -RFTN1 5.13898056372008e-12 -KCNH8 0.000102483662649291 -MRPS25 0.545528804168266 -TBC1D5 6.51864399070986e-10 -ZFYVE20 0.016782703504972 -DAZL 0.961607975742939 -HACL1 4.18066326371778e-10 -PLCL2 0.999118779774419 -DPH3 0.0446708183979692 -CAPN7 5.28615018685299e-07 -BTD 1.28845384445698e-06 -UBE2E1 0.872957997407213 -EOMES 0.71187838114463 -OXSM 0.00330641693750777 -NGLY1 2.20290079449091e-10 -ZNF385D 0.724321866793819 -SGOL1 2.46285208677179e-07 -SLC4A7 0.69770797268161 -RARB 0.999317519370488 -UBE2E2 0.924393312463155 -LRRC3B 0.228541145950027 -NKIRAS1 0.0348877719884207 -NEK10 0.000236569051864242 -THRB 0.994541861187431 -KAT2B 0.998926901286195 -TOP2B 0.99731109311551 -NR1D2 0.631421779865195 -RAB5A 0.774403049424523 -RPL15 0.956294173685839 -TGFBR2 0.0355927009989093 -TRIM71 0.993173544222524 -GPD1L 0.00953782790179044 -AZI2 0.185308909021358 -OSBPL10 0.000141845926676448 -ZCWPW2 6.76412703598574e-05 -CCR4 0.760806752827452 -RBMS3 0.741403241313464 -STT3B 0.980028091148833 -CMTM8 0.847881588243377 -GLB1 4.86457143252396e-08 -TMPPE 4.8633767753696e-05 -CRTAP 5.34389142589516e-05 -CMTM7 0.426220205435479 -CNOT10 0.999834446356576 -GADL1 5.39098728033269e-09 -DYNC1LI1 0.977918890005446 -CMC1 0.00144188642781411 -CMTM6 0.822756767085209 -ZNF860 7.85955632803042e-11 -SUSD5 4.30999192934607e-09 -EPM2AIP1 0.164415268467168 -FBXL2 0.216479060538488 -C3orf35 0.014135320099321 -STAC 0.0107102692074456 -PDCD6IP 0.751958921876168 -CLASP2 0.999948359508774 -ACAA1 2.6382494578646e-05 -ARPP21 0.00367693074803101 -UBP1 0.999799486559086 -DCLK3 0.439315817627167 -VILL 3.00934969096386e-12 -CTDSPL 0.0888481859287146 -ITGA9 0.0961917478256693 -PLCD1 2.55415564522998e-09 -LRRFIP2 4.80060455389411e-08 -DLEC1 6.45016367111782e-18 -MLH1 0.739578311354265 -GOLGA4 2.26164990605558e-09 -TRANK1 2.79379160018064e-10 -MOBP 0.592010032536213 -SCN5A 0.995747526532478 -WDR48 0.999805648456572 -CCR8 0.0176258189185473 -OXSR1 0.989117555735273 -EXOG 2.8645498363351e-08 -SCN10A 6.14214934293813e-26 -XYLB 2.62886453689458e-13 -CX3CR1 0.107291641248763 -GORASP1 0.698377750425013 -CSRNP1 0.59953098933972 -TTC21A 2.120275914728e-16 -SLC25A38 0.0682178285427916 -SLC22A14 9.57031766361908e-09 -SLC22A13 2.16075768642524e-15 -SCN11A 2.51866017251712e-19 -MYD88 0.711854614335331 -RPSA 0.751851425879316 -ACVR2B 0.993110896136122 -XIRP1 2.18393838159372e-17 -ZNF621 4.17647812895176e-05 -CTNNB1 0.999812749503708 -ZNF620 6.82676319543398e-06 -LYZL4 0.112282902130519 -SS18L2 0.0602071955135164 -ULK4 1.68589239610196e-23 -CCDC13 1.15875211638949e-07 -ZBTB47 0.974750217387723 -HHATL 1.48700262097741e-05 -ZNF619 2.36447989133731e-05 -RPL14 0.936435427719195 -SEC22C 1.72380785269272e-06 -MYRIP 0.000902541100654773 -KLHL40 0.0781027060776258 -TRAK1 9.70917112523944e-05 -CCK 0.0231054020414021 -EIF1B 0.394740519246042 -NKTR 0.991877509743874 -ENTPD3 2.55562814397697e-19 -VIPR1 8.27528331892667e-10 -HIGD1A 0.450480881720745 -POMGNT2 0.00772677154516411 -ZNF662 3.7181666705829e-10 -TCAIM 4.45858902178291e-05 -ZNF445 0.996478491372579 -ZNF660 0.0548051045454931 -ANO10 1.92259540732638e-06 -ZNF502 1.40776549102333e-05 -ZNF501 0.00549805795272302 -KRBOX1 0.416823600155305 -ZNF35 0.0792906266095248 -ACKR2 0.000376890363248093 -ZKSCAN7 1.17628257340827e-05 -ABHD5 3.45366245550968e-05 -ZNF852 6.53650192013867e-09 -ZNF197 5.95384346361306e-14 -SNRK 0.994142267780069 -CYP8B1 0.00051293164796349 -CCR1 0.891828751553939 -LZTFL1 0.194102810474707 -FYCO1 9.66912529361977e-13 -LIMD1 0.127770680853122 -CDCP1 0.0211525261340679 -TGM4 1.13522291514052e-11 -ZDHHC3 0.144015391144747 -CXCR6 6.15120183208142e-05 -CLEC3B 0.000380110335261023 -CCR3 0.0318930527902387 -LARS2 2.60643828587561e-07 -TMEM158 0.382809463415714 -KIF15 7.46949818975046e-13 -KIAA1143 0.025102469555063 -XCR1 0.0978541501235188 -SACM1L 0.721901742734862 -EXOSC7 0.0141395293232584 -CCR9 0.00464030866963606 -TMEM42 0.306977503268514 -SLC6A20 6.44898031809492e-10 -LTF 1.76023213454946e-13 -SETD2 0.999992944074178 -TMIE 0.000366606281610635 -ALS2CL 2.72979618994274e-18 -CCDC12 0.774130719749877 -MYL3 0.888080620769772 -PRSS50 2.62070748435681e-05 -CCRL2 0.00216377842930582 -NBEAL2 0.862533062213951 -RTP3 0.181516461400941 -PTH1R 0.742389488872585 -PRSS45 8.77664623875441e-05 -CCR2 0.0114633179449999 -CCR5 3.51208840566472e-08 -LRRC2 4.7683181051694e-05 -KIF9 2.17357320878688e-11 -PRSS42 4.68320795534589e-05 -TDGF1 3.98298058552725e-06 -PTPN23 0.647596781106679 -ELP6 0.00350789886566748 -TMA7 0.0100073079474151 -SHISA5 9.94272259623573e-08 -DHX30 0.999999462569762 -NME6 9.2163606322478e-05 -FBXW12 1.97457661872321e-07 -CCDC51 1.46055955445772e-06 -TREX1 0.093340719174628 -CSPG5 0.414829723073552 -CAMP 0.0896557021569683 -SCAP 0.0225547504834219 -CDC25A 0.979698044533755 -SMARCC1 0.999999593393603 -KLHL18 0.984175216789434 -ATRIP 0.00148697990787471 -ZNF589 6.50060605876318e-07 -PLXNB1 0.85019510818446 -MAP4 0.99884872439436 -SPINK8 0.00112128585214279 -SLC26A6 3.31045065696163e-05 -P4HTM 0.0232749358306657 -UQCRC1 0.132467103146211 -QARS 8.78969829865226e-08 -TMEM89 0.711075964906752 -CELSR3 0.999656221390747 -NDUFAF3 4.85972513641338e-05 -WDR6 9.19647551585082e-07 -DALRD3 1.84813920683629e-05 -SLC25A20 2.04566835698354e-07 -UCN2 0.157235729046978 -IP6K2 0.989457702873501 -NCKIPSD 0.00713136165785669 -COL7A1 2.10611122198023e-18 -QRICH1 0.996069748046578 -PFKFB4 0.000321134414442041 -ARIH2 0.987412494790781 -PRKAR2A 0.983250575891508 -IMPDH2 0.00135316628366044 -ARIH2OS 0.437613435241329 -GPX1 0.00693165111693131 -DAG1 0.940921791331691 -APEH 0.0132157073381975 -AMIGO3 7.50516210752013e-06 -RHOA 0.804697934205436 -NICN1 0.257245528868092 -CCDC71 0.0169896394893115 -RNF123 0.969714693858756 -C3orf84 0.000221291799515334 -MST1 1.72735679966035e-10 -LAMB2 7.45006902753361e-11 -KLHDC8B 0.010421420264697 -USP4 6.20193619608728e-07 -C3orf62 0.00712465933483595 -USP19 0.999991981492882 -BSN 0.999999992077176 -CCDC36 0.509348612076541 -AMT 0.000569475286585638 -TCTA 0.0132648475524679 -GNAT1 2.50523154178956e-06 -RBM5 0.999999469802352 -LSMEM2 2.89143693080036e-05 -UBA7 2.68227797741532e-14 -CAMKV 0.996846171233152 -CDHR4 0.0134739491219744 -NAT6 0.402945153314903 -IP6K1 0.235179980766781 -SEMA3F 0.999917700468544 -MST1R 1.6934911102813e-20 -HYAL1 0.0055367061124395 -RBM6 0.999999963583324 -FAM212A 0.000589161385315042 -GMPPB 8.24535896597197e-05 -TRAIP 0.125103591601554 -HYAL3 1.52465574848001e-05 -MON1A 0.00636811048934964 -IFRD2 5.52609563426163e-06 -GNAI2 0.861160290278213 -NPRL2 0.345174793559064 -CYB561D2 0.0147104753856424 -GRM2 0.983083426226356 -HEMK1 8.23152653057192e-05 -MAPKAPK3 2.71040946081621e-06 -RASSF1 4.85820372401728e-08 -ZMYND10 3.60239883453688e-07 -TUSC2 0.703033003634111 -CISH 0.00144425763962849 -MANF 0.327002524454327 -TEX264 0.910814338863852 -RBM15B 0.998677123640892 -DOCK3 0.999999698562023 -TMEM115 0.876895269487346 -XXcos-LUCA11.5 0.206890278846601 -CACNA2D2 0.999693296855458 -C3orf18 0.0143080084934581 -HYAL2 0.0206315124398338 -RAD54L2 0.999999053426257 -IQCF1 0.0468541004756609 -DUSP7 0.228528646563016 -RRP9 0.3420434837746 -ALAS1 0.907956554078195 -PARP3 1.48672469453256e-08 -POC1A 1.1532167339453e-05 -LINC00696 0.211998268274444 -ACY1 7.69184316863466e-05 -TLR9 0.000525225802125772 -ABHD14B 0.116162846197975 -PPM1M 0.0923289257222666 -GPR62 0.229621630878426 -RPL29 0.597262029881945 -ABHD14A 0.000234514195858804 -PCBP4 0.233370935826447 -TWF2 0.857810163904333 -ABHD14A-ACY1 2.24506546646095e-05 -IQCF2 0.000296978107855683 -IQCF3 0.127529596598468 -IQCF5 0.433199985636479 -NEK4 1.21649867284356e-12 -ITIH3 6.66881160948057e-12 -GLYCTK 1.36482731873284e-06 -DNAH1 4.42227332517076e-20 -NISCH 0.817101389344283 -GLT8D1 0.00348977535071494 -NT5DC2 0.0046088659492231 -WDR82 0.923062143793669 -ITIH4 4.63110952740984e-05 -BAP1 0.385637503937077 -SPCS1 0.118910837533606 -GNL3 1.53959646341731e-09 -PHF7 0.0649138823166041 -STAB1 2.79798765369336e-25 -ITIH1 4.79131815203759e-18 -TNNC1 0.510486367884133 -SEMA3G 6.07682770496396e-10 -MUSTN1 0.00175218786439621 -PBRM1 0.999999987154091 -WNT5A 0.974673047386647 -SELK 0.00322865297478492 -CACNA1D 0.99999999998943 -TMEM110-MUSTN1 0.684628071972952 -LRTM1 5.24712732718947e-09 -ARHGEF3 0.991271357501421 -CACNA2D3 0.998032255145607 -CCDC66 8.98685926047288e-28 -SFMBT1 0.99589420844432 -ERC2 0.9968564624658 -TKT 0.0602834945523099 -IL17RB 3.50844752193209e-08 -CHDH 0.00530866013391797 -DCP1A 0.943913887681161 -RFT1 3.17066987972078e-06 -FAM208A 0.999672316077973 -ACTR8 2.01457015209018e-08 -TMEM110 0.901349032819805 -PRKCD 0.997593706576692 -SPATA12 0.00717463491260291 -IL17RD 2.6354985095282e-05 -FAM107A 0.00164508891972831 -RPP14 0.147340973271617 -ARF4 0.931562500213935 -PDE12 0.0235724225080969 -FAM3D 0.00403090933804102 -HESX1 0.00816309859692874 -ABHD6 0.00255991600957779 -ACOX2 1.54733558790157e-09 -DNAH12 0.000394165957730919 -C3orf67 1.50533862917062e-05 -PXK 0.932144255708936 -APPL1 0.18416100961266 -ASB14 6.07961312910373e-10 -DENND6A 0.852272523176061 -PDHB 0.357305589322301 -DNASE1L3 0.155489629437521 -SLMAP 0.999325964654365 -FLNB 0.00243124047488239 -KCTD6 0.206951627204982 -FHIT 0.00139183900459992 -SNTN 0.00273794435957524 -SYNPR 0.171706356156551 -SUCLG2 3.28018373617218e-05 -PTPRG 0.00417657315674374 -LRIG1 0.835793558274592 -MAGI1 0.999615674506819 -PRICKLE2 0.987837185730764 -CADPS 0.0528164675314738 -THOC7 0.978320488745139 -C3orf14 1.59540116585515e-06 -FAM19A1 0.861963100838969 -SLC25A26 4.24371628598418e-09 -FEZF2 0.902033503582519 -ADAMTS9 4.22655241635146e-07 -KBTBD8 0.00167056987470839 -PSMD6 0.962085714874074 -ATXN7 0.928556027503616 -PDZRN3 0.908376144076894 -SHQ1 1.16644798453142e-10 -EIF4E3 0.00423250331377467 -CNTN3 0.0141417862555819 -LMOD3 0.00805841552794795 -MITF 0.997810643539312 -GXYLT2 1.76182494127584e-06 -GPR27 0.598851196353134 -PPP4R2 0.98805629012284 -FRMD4B 0.807013707732818 -ZNF717 0.332205459126617 -PROK2 0.270454067222245 -EOGT 9.78550475841108e-06 -ARL6IP5 0.313164924329023 -FAM19A4 0.198148820346351 -FOXP1 0.999750735055125 -UBA3 0.967546957863583 -TMF1 2.8391125268012e-06 -EBLN2 0.0865230043591697 -ROBO1 3.04028778350882e-08 -EPHA6 0.954513146757851 -STX19 1.15387050808179e-05 -CGGBP1 0.777631517643376 -VGLL3 0.336018871714114 -EPHA3 0.0156859621990761 -ROBO2 0.99999613022592 -ZNF654 0.947346014675446 -ARL13B 1.39144766800328e-06 -HTR1F 0.00161477471674346 -GBE1 1.17856543699791e-13 -PROS1 0.000209233911903675 -DHFRL1 0.102597562557193 -C3orf38 0.00699878324708333 -POU1F1 0.618818418545953 -CHMP2B 0.0130803147575514 -CADM2 0.984668909563275 -NSUN3 2.56992377769436e-07 -CPOX 0.0232273467536485 -COL8A1 0.0381673646294114 -ARL6 0.0042708684124606 -DCBLD2 0.000553237247244631 -OR5H2 1.56486567272373e-05 -OR5H15 1.77804938664206e-06 -OR5K4 9.27165287016062e-07 -OR5K3 0.00192053079542076 -OR5H1 0.0674147765122453 -GPR15 0.00326499920869601 -OR5AC2 5.95935728781755e-05 -OR5K2 9.18743788922924e-05 -CRYBG3 0.000473718112503729 -OR5H6 4.75403468374202e-05 -OR5K1 9.41011918854772e-05 -CMSS1 0.000665484679606108 -ST3GAL6 0.00106167207338745 -OR5H14 0.000175213979260701 -MINA 1.5762094096492e-05 -CLDND1 0.590515429063808 -ZBTB11 0.269451352114294 -ZPLD1 0.000311007049144322 -CEP97 1.32650017854034e-06 -NIT2 1.59970723969675e-10 -IMPG2 1.4748151437863e-08 -GPR128 1.98948574576502e-11 -TFG 0.757056423125628 -TOMM70A 0.998235566053271 -NFKBIZ 0.999616951200414 -FILIP1L 0.000245912456600934 -TMEM45A 0.0101836251559842 -TBC1D23 0.000111511568799616 -PCNP 0.872423409746757 -LNP1 0.00188517623884581 -TRMT10C 1.05912396335495e-05 -SENP7 0.987260725175161 -NXPE3 0.402099827242488 -RPL24 0.864299873369858 -ABI3BP 3.9401554209396e-07 -BBX 0.958097848857497 -ZBED2 0.00205866015297017 -CD47 0.886113810883053 -MYH15 4.73936233784156e-39 -MORC1 0.000240876467310313 -DPPA2 7.75895224134516e-08 -CBLB 0.913125166981959 -CD96 1.00320569768936e-05 -PVRL3 0.733660990323007 -CCDC54 8.5500859196346e-08 -IFT57 4.07945731178608e-06 -KIAA1524 5.75236747593882e-08 -TRAT1 0.486401716946783 -RETNLB 0.0099474568203867 -GUCA1C 0.000632586350938465 -DPPA4 0.0016014612995864 -DZIP3 3.74220282201281e-10 -HHLA2 8.08523957370927e-05 -ALCAM 0.98833623820425 -PLCXD2 5.16800987455644e-05 -BTLA 0.430977023003583 -GTPBP8 2.88123347250605e-06 -WDR52 4.18629122672432e-06 -CD200R1 7.03843365792991e-09 -SLC35A5 0.00141225113499444 -ABHD10 0.000658971112003106 -BOC 0.00472748578589258 -CCDC80 0.00584309877267669 -TMPRSS7 6.09045610445382e-15 -TAGLN3 0.685406597871256 -PHLDB2 0.0112157669847478 -SPICE1 5.13620862858274e-08 -C3orf17 9.41502116744778e-05 -C3orf52 1.27244581516247e-08 -GCSAM 0.0985013069335167 -CD200R1L 0.00306227329023055 -SLC9C1 7.81673916364206e-11 -ATG3 0.978991920554431 -CD200 0.160238630083487 -LSAMP 0.946283746572624 -DRD3 0.0102953433153304 -GAP43 0.0123799221019638 -C3orf30 1.64784502765984e-06 -TMEM39A 0.979617998375633 -ZBTB20 0.982557230407655 -B4GALT4 2.32860130735228e-06 -ARHGAP31 0.999634465686628 -IGSF11 0.175167238322195 -TIGIT 0.0451499001724995 -ATP6V1A 0.986543791938074 -SIDT1 5.02880784411406e-13 -ZDHHC23 3.89032529135583e-06 -GRAMD1C 8.13050191922526e-10 -ZNF80 5.32106862981897e-08 -UPK1B 4.50333086319676e-05 -QTRTD1 2.19116828365188e-05 -NAA50 0.876848812692325 -KIAA1407 3.28846696637553e-23 -KIAA2018 0.999948325292411 -ARGFX 1.03484051516333e-05 -POLQ 9.94639217152803e-47 -PLA1A 0.00169014777230665 -GSK3B 0.998731142420546 -COX17 0.515141893437219 -LRRC58 0.0191326932920517 -RABL3 0.136652214705715 -GPR156 3.67917855529623e-07 -MAATS1 9.7774896920592e-10 -NR1I2 0.000129416843964785 -CD80 0.25522458111489 -POGLUT1 0.000114466389873238 -STXBP5L 0.99994837069221 -ADPRH 8.59498396157278e-06 -POPDC2 0.000116007752087542 -TIMMDC1 5.67649555021519e-07 -HGD 6.42452291651269e-05 -FSTL1 0.959341928524645 -NDUFB4 0.00226606590074798 -GTF2E1 0.902579885844598 -EAF2 0.000680757757036257 -GOLGB1 4.23236652462592e-06 -PARP9 5.1404381489417e-06 -CCDC58 0.0802761221198354 -CSTA 0.000533613519559043 -PARP15 2.70928333439315e-07 -DTX3L 2.44159143785208e-05 -CD86 0.962700436186593 -FAM162A 0.000629842253416895 -ILDR1 7.93588407013792e-07 -PARP14 0.0129606904086898 -SLC15A2 1.50274634978985e-10 -FBXO40 3.6419894887019e-08 -KPNA1 0.993000949687577 -DIRC2 6.7997685830619e-06 -WDR5B 5.46914499159414e-05 -CASR 0.366508674072432 -HSPBAP1 9.97537509364561e-07 -HCLS1 5.08798891518146e-05 -IQCB1 1.19705337503096e-07 -PTPLB 0.922342684585728 -SLC12A8 7.93459144299657e-13 -SLC41A3 0.000139670421791452 -HEG1 6.98959647837495e-06 -SEMA5B 0.00033149979824729 -PDIA5 1.00405592105616e-06 -ADCY5 0.989940591837607 -KALRN 0.999996915329978 -MYLK 9.37919861515833e-06 -SEC22A 0.638909264916314 -ITGB5 0.000480018789158923 -ROPN1B 5.67126033394535e-05 -UMPS 0.000109217442760822 -SNX4 0.011061878512626 -ZNF148 0.932274762499269 -CCDC14 3.40559309548439e-07 -MUC13 0.0251339159380931 -ROPN1 0.00818535249401917 -OSBPL11 0.898599332497567 -ALG1L 3.26303190374336e-09 -CCDC37 4.72529645072491e-14 -EEFSEC 0.0131152875630723 -PODXL2 0.977986099041167 -MCM2 0.509038119651144 -TXNRD3NB 0.00177417484616752 -C3orf22 0.127310951022659 -UROC1 3.35644591456772e-10 -ALDH1L1 9.61783695417292e-06 -ZXDC 0.000818651643605645 -C3orf56 2.51567990011522e-07 -KBTBD12 9.96465322017853e-13 -ABTB1 0.00129830665139568 -KLF15 0.435175998587426 -CHST13 0.000159791662950939 -MGLL 0.00459891048076127 -PLXNA1 0.999998424887592 -RUVBL1 0.998897690232788 -TPRA1 0.0583580196535496 -CHCHD6 1.0801836127763e-08 -SEC61A1 0.995608071830047 -RPN1 0.664450734249708 -ACAD9 2.07158412910707e-05 -GATA2 0.979762089854754 -EFCC1 0.000466919773276265 -RAB43 0.341400602766556 -HMCES 4.51657466936959e-05 -IFT122 2.16271033723115e-11 -C3orf27 0.0294465914150084 -CNBP 0.92057305466698 -MBD4 1.69561035781758e-06 -ISY1-RAB43 0.99889493512477 -RAB7A 0.922269115879691 -H1FX 0.496856075371417 -DNAJB8 0.0475406871720836 -COPG1 0.998499313833563 -ISY1 0.998290706422744 -EFCAB12 2.17729967150611e-06 -GP9 0.570607601028968 -KIAA1257 1.74543485053087e-08 -PLXND1 0.999989724505468 -COL6A5 9.56358791513705e-12 -TMCC1 0.209385317152585 -PIK3R4 0.707146275693906 -CPNE4 0.775139285096664 -RHO 0.000556528415833613 -ACAD11 1.67704087843789e-07 -TRH 0.0108069146502521 -NUDT16 0.00146067601382414 -MRPL3 2.80524857561429e-08 -ACKR4 0.0074451081605227 -COL6A6 3.59168701863295e-45 -H1FOO 0.398598145711215 -NEK11 3.82253260833349e-17 -DNAJC13 0.999999999681765 -UBA5 0.745375692202932 -NPHP3 1.41114914876655e-09 -ACPP 1.75749793157423e-07 -ASTE1 3.39138941425054e-12 -ATP2C1 0.999798834520344 -KY 1.0676447551172e-08 -PCCB 0.000735839433891269 -SRPRB 0.0107906261312511 -EPHB1 0.998398641021365 -NCK1 0.00103502587808822 -CEP63 8.50276907222801e-21 -TOPBP1 0.999999933511461 -ANAPC13 0.00134979464058177 -STAG1 0.999999910022904 -RAB6B 0.893311148938933 -AMOTL2 0.207914897262679 -MSL2 0.889663741822694 -TF 0.00237226565881044 -SLC35G2 0.0663953363472009 -CDV3 0.201907143848833 -SLCO2A1 2.25372891314708e-09 -PPP2R3A 0.920487875254504 -BFSP2 6.66210219090541e-05 -TMEM108 0.983718759593856 -C3orf36 0.00367253659454535 -IL20RB 0.000354183473406977 -MRPS22 6.39409151183266e-05 -COPB2 0.999998457069596 -A4GNT 0.598408702159303 -CEP70 5.9520361020633e-11 -PRR23A 0.0180799350653936 -FAIM 0.0681171937664527 -DBR1 8.70518439226155e-05 -PRR23C 0.000636017536157745 -MRAS 0.859946833275581 -ESYT3 2.43267295856475e-11 -CLDN18 0.0126449337520513 -PIK3CB 0.999979002310697 -C3orf72 0.0934370542464938 -PRR23B 0.0025340200634616 -NME9 2.62520678425012e-05 -ARMC8 0.999883770038606 -DZIP1L 6.92918542273119e-20 -SOX14 0.720669571974876 -XRN1 0.995837599420394 -RNF7 0.0145273267605025 -ATR 0.701297833041861 -RBP2 0.433554514449151 -SPSB4 0.0052286394184106 -ATP1B3 0.641391596618863 -SLC25A36 0.88301361858947 -GRK7 1.19306241308231e-07 -RBP1 0.000490535137623092 -ACPL2 0.215526325024235 -GK5 0.519887601252046 -TFDP2 0.975087598074196 -ZBTB38 0.97949144936684 -PLS1 0.000310388416470486 -RASA2 5.3166662616203e-17 -TRIM42 5.57634194724097e-15 -CLSTN2 4.5392971229794e-05 -PCOLCE2 6.87765105520563e-07 -TRPC1 0.784921837002802 -NMNAT3 5.34376100617257e-08 -ZIC4 0.00181690392137032 -PLSCR2 2.19480995516763e-05 -SLC9A9 2.47740520992669e-08 -ZIC1 0.825224393438112 -HPS3 3.52030440679389e-15 -PLSCR4 0.00169240896275056 -PAQR9 0.80079430697556 -PLSCR5 1.16765638368877e-09 -PLOD2 0.00117484049993417 -CPA3 1.2834341428345e-12 -PLSCR1 0.00293164530943767 -CPB1 2.26972023407954e-14 -HLTF 6.80799092701924e-20 -CHST2 0.123805841170553 -AGTR1 0.00727625074022701 -CP 0.000168752233046611 -U2SURP 0.999999613278695 -GYG1 6.90635734321028e-07 -C3orf58 0.162503916327723 -GPR171 0.00167512127492569 -P2RY14 0.000377084300253391 -P2RY13 0.327928323861021 -TSC22D2 0.831881107448022 -WWTR1 0.918871194380801 -RNF13 0.00198548907909874 -TM4SF4 0.00251101484799328 -CLRN1 0.000915821935109622 -SIAH2 0.360182186098013 -TM4SF1 0.000859110031523055 -TM4SF18 2.10380518922091e-07 -PFN2 0.638693741946579 -SELT 0.143778780365533 -MED12L 0.99999927637145 -FAM194A 1.41957265019042e-19 -SERP1 0.211802393028658 -GPR87 0.290536848999693 -COMMD2 3.65344719758037e-07 -EIF2A 0.00015893869213679 -PLCH1 0.425540924509534 -KCNAB1 0.0665503434443176 -TMEM14E 0.185564714484572 -IGSF10 2.98760657394284e-36 -ARHGEF26 5.99162897861342e-06 -AADAC 0.000181834436419695 -GPR149 2.6464400182055e-05 -MBNL1 0.981577652065926 -C3orf79 0.260312468461099 -AADACL2 1.78138870795841e-08 -DHX36 0.99055580055265 -MME 2.19309064304115e-08 -RAP2B 0.275476507802157 -GMPS 0.993904305716876 -P2RY12 0.107032257879275 -SUCNR1 6.24867481072073e-08 -C3orf33 1.52110426864005e-07 -P2RY1 0.581732803893959 -SLC33A1 0.100521117903096 -GFM1 1.66398179768796e-06 -RSRC1 3.41025677860813e-05 -CCNL1 0.942872593157657 -RARRES1 8.40651968753382e-07 -PTX3 0.0129819003080692 -LXN 0.00362044465677788 -IQCJ 0.0984293652546805 -MFSD1 1.01997314131748e-09 -IFT80 1.44402047985056e-10 -TIPARP 0.997752090167203 -IQCJ-SCHIP1 0.66050205956069 -SHOX2 0.0852112280919416 -IL12A 0.299096926040613 -MLF1 1.28387834312483e-06 -VEPH1 9.32876839110736e-12 -C3orf55 0.0392312788649 -SCHIP1 0.956602926491204 -SSR3 0.301905502483941 -TRIM59 0.0321109566837029 -B3GALNT1 0.248006524456185 -SMC4 0.105530996358142 -MECOM 0.999085313439389 -SLITRK3 0.603043296412279 -SERPINI1 0.930874238033153 -SERPINI2 1.99904531615741e-10 -GOLIM4 5.53788033369551e-11 -ZBBX 4.33160126727107e-11 -ACTRT3 0.000670123620467876 -BCHE 4.44441991561661e-11 -WDR49 2.29866609656679e-12 -OTOL1 1.71727944749843e-07 -SPTSSB 0.00589959099120582 -ARL14 2.57323247313565e-06 -PPM1L 0.570549299339256 -KPNA4 0.998180756390855 -PDCD10 0.985734930905909 -SI 7.97067187590746e-26 -NMD3 4.4226191654738e-05 -MYNN 0.650144393600751 -GPR160 0.00375671992599514 -SLC2A2 7.53167438901512e-05 -PRKCI 0.253553082477709 -EIF5A2 0.167390171566573 -SLC7A14 0.332594381838482 -LRRIQ4 0.00168554785571336 -PHC3 0.99995554091245 -PLD1 7.20704885136773e-16 -RPL22L1 0.0939593928074091 -SKIL 0.459267762614766 -SEC62 0.967257862682972 -FNDC3B 0.999999985029909 -TNIK 0.997185845677764 -LRRC31 5.24031482355817e-06 -CLDN11 0.32891224511477 -SAMD7 6.78008462543362e-06 -LRRC34 5.88856097246935e-07 -USP13 2.17337060975034e-08 -NDUFB5 0.00344108897309257 -GHSR 0.0433453469862917 -TNFSF10 0.405364744467663 -KCNMB2 0.652459629699188 -SPATA16 1.64842747374149e-06 -ECT2 2.55528752962742e-05 -NLGN1 0.755797511974091 -PIK3CA 0.99999851122751 -TBL1XR1 0.998821952425029 -ZNF639 0.122945965165128 -GNB4 0.629775083415026 -MRPL47 0.000142436318907292 -NAALADL2 3.04144463822372e-06 -ACTL6A 0.992221335003384 -ZMAT3 0.0567031582457627 -MFN1 0.0190381900124968 -KCNMB3 2.57857245438483e-08 -NCEH1 0.00107451129620312 -HTR3C 2.33900863158536e-08 -FXR1 0.999992197639482 -DCUN1D1 0.990513001427957 -ABCC5 0.896205134921104 -MAP6D1 0.0518280033537145 -MCF2L2 1.61269129905986e-12 -PARL 1.07316888361272e-05 -CCDC39 5.10298688091632e-05 -B3GNT5 0.630704047253903 -MCCC1 2.51105898766941e-05 -YEATS2 0.999977828893892 -PEX5L 0.664004906251205 -HTR3D 2.59130296079301e-06 -LAMP3 0.833342526965146 -KLHL6 3.42666879196839e-06 -ATP11B 0.992834850949756 -SOX2 0.396696528099993 -KLHL24 0.252414430146934 -TTC14 4.41871480046018e-06 -DNAJC19 0.0144036901582712 -VPS8 3.61819753295781e-06 -HTR3E 0.00133646646478871 -CAMK2N2 0.320487800680099 -CLCN2 2.26513810859121e-07 -CHRD 0.00038124723708207 -EIF2B5 0.996711860525997 -EPHB3 0.956539592127129 -VWA5B2 0.354623648336578 -DVL3 0.995402942345558 -ALG3 4.17818824908735e-06 -AP2M1 0.993893174243241 -THPO 0.00514022944754883 -POLR2H 0.902767280232976 -ABCF3 0.00402616582072083 -EIF4G1 0.999999999936491 -ECE2 1.65047866122531e-17 -FAM131A 0.0313284236342615 -PSMD2 0.999997115740613 -MAGEF1 0.0340314663613953 -KNG1 4.17299309157391e-08 -C3orf70 0.00239094751008584 -TRA2B 0.988418187489854 -EHHADH 8.50410911635847e-11 -TMEM41A 0.00224660859113542 -CRYGS 0.182730047254129 -AHSG 2.86452047704873e-08 -IGF2BP2 0.942124149210594 -HRG 1.70020586338944e-12 -TBCCD1 0.0121109839106441 -EIF4A2 0.997112604533517 -DNAJB11 0.909930974034799 -C3orf65 0.0636621541218024 -SENP2 0.998304834433867 -ETV5 0.999892475775242 -FETUB 6.8836490746529e-05 -RFC4 9.67497618265728e-05 -MAP3K13 0.966849138305972 -LIPH 2.13279458867521e-06 -DGKG 5.43821441070651e-06 -SST 0.66549802364856 -RTP1 0.56382972565799 -RPL39L 0.175781234610387 -ADIPOQ 5.61889056767483e-07 -TPRG1 4.87825873738663e-05 -RTP4 0.0108456456084385 -TP63 0.983222202403613 -LEPREL1 6.48633510490974e-10 -BCL6 0.982525139432015 -TMEM207 0.000192958975824054 -RP11-211G3.3 0.75732929368071 -ST6GAL1 0.814435677774412 -IL1RAP 0.506746749056946 -MASP1 9.74280364714267e-06 -RTP2 0.00338105493146928 -CLDN16 0.0333869032212615 -LPP 0.582399908119384 -CLDN1 0.0581349308262247 -UTS2B 0.0110399911903071 -MB21D2 0.385737570551862 -CPN2 0.00023179534317588 -ATP13A4 6.07648654021509e-10 -HES1 0.644078951582769 -LSG1 6.58805364159815e-07 -CCDC50 9.33289305733199e-06 -XXYLT1 0.0516035068341256 -ACAP2 0.999918184975784 -FGF12 0.114210585344935 -ATP13A3 0.999967444596667 -GP5 4.00900429038836e-06 -ATP13A5 6.22871619777347e-28 -OSTN 0.0858560507076122 -PYDC2 0.0221705221528128 -TMEM44 1.19424157266321e-06 -HRASLS 0.000717831128354625 -LRRC15 1.35693788842668e-06 -OPA1 0.994351455893758 -TM4SF19 0.0139308428726723 -SMCO1 4.62967906395968e-05 -PAK2 0.938688563524374 -TNK2 1.20620740888102e-10 -PCYT1A 0.0983000755796718 -RNF168 1.37259354976502e-10 -UBXN7 0.990657189537173 -FBXO45 0.857972569151264 -TCTEX1D2 0.000234712184365325 -CEP19 0.0526189332458462 -SLC51A 0.0575688115148571 -ZDHHC19 0.0524274267287205 -NRROS 0.457686197904668 -APOD 0.000853904292818293 -WDR53 0.000341188959787833 -PPP1R2 0.04270925654256 -SENP5 0.996261182637231 -TFRC 0.780323176637487 -RPL35A 0.914385546016633 -FYTTD1 0.829001566647634 -KIAA0226 4.7700136988124e-06 -LMLN 7.35628703193249e-06 -LRCH3 1.19680658993201e-08 -PIGZ 0.000159853219090366 -IQCG 3.61162236640437e-15 -DLG1 0.998742049204796 -BDH1 0.000383112941167296 -MFI2 7.70860150304015e-12 -NCBP2 0.266930249458524 -IDUA 2.64182167327825e-08 -SLC26A1 4.01304192741795e-06 -MFSD7 2.75660020784589e-12 -ZNF595 1.77527172321732e-05 -ZNF732 1.31184093398498e-09 -RNF212 0.125225584495356 -ZNF721 5.97289371219059e-11 -CTBP1 0.979763654461024 -TMEM175 0.000439629704611645 -FGFRL1 0.582186675448565 -MYL5 4.42986035820118e-08 -GAK 0.973134951387495 -ZNF141 0.161888983164538 -PCGF3 0.943399926818786 -SPON2 1.0881191748191e-06 -PDE6B 1.62565147164988e-13 -ATP5I 0.207299098398329 -DGKQ 0.0011940236557909 -CPLX1 0.795789957123327 -PIGG 8.77510701005957e-07 -POLN 2.99655974305971e-32 -NAT8L 0.32467788359779 -UVSSA 8.88754059993399e-14 -NKX1-1 0.188420302823464 -HAUS3 8.89916619400129e-07 -ZFYVE28 0.88846014978575 -FGFR3 0.00290912236409275 -NELFA 0.166888720234175 -MAEA 0.844858361058156 -MXD4 0.896936709353244 -TMEM129 1.57455519983462e-06 -TACC3 0.0919518142926963 -WHSC1 0.999999325434983 -SLBP 0.51565945835262 -LETM1 0.0810547259175606 -RNF4 0.628950995184494 -FAM53A 3.00698000612452e-05 -CRIPAK 2.43127197997244e-12 -LYAR 0.000132448509465871 -NOP14 0.0174491653147605 -DOK7 0.00480838202293031 -ZBTB49 0.00916415492518601 -TMEM128 0.110058362630308 -GRK4 5.6904219834531e-07 -ADD1 0.611299255784318 -HGFAC 5.20820571636199e-07 -MFSD10 3.01777310462786e-07 -MSANTD1 0.32217221350423 -LRPAP1 0.00608430596153667 -OTOP1 7.31470990584692e-16 -NSG1 0.00453828786793088 -TNIP2 2.97330525116274e-06 -RGS12 0.00056037428714452 -SH3BP2 0.00310189992242549 -HTT 0.999999999968547 -ADRA2C 0.645951820563209 -FAM193A 0.997818289407157 -JAKMIP1 0.993166783894696 -TBC1D14 0.909001498276562 -STX18 1.16778720480768e-06 -MAN2B2 4.35731486928261e-18 -MRFAP1 0.177064470221167 -KIAA0232 0.99472089633487 -MRFAP1L1 0.008908008002048 -S100P 0.0486493649314778 -PPP2R2C 0.564450094959733 -C4orf6 4.5834627829078e-07 -EVC2 1.0533170759541e-21 -C4orf50 6.34225080498418e-10 -MSX1 0.275361731184646 -BLOC1S4 0.158972119673534 -EVC 8.01499590160707e-08 -CRMP1 0.953273234767141 -CYTL1 0.000652770817543667 -STK32B 0.00432349027379393 -HMX1 0.125284952216653 -PSAPL1 3.33502575049141e-11 -AFAP1 0.376071779661091 -SORCS2 0.00264628823985857 -TRMT44 1.47758486898954e-13 -GPR78 1.28260435114209e-05 -SH3TC1 1.08196254711814e-27 -ACOX3 3.03156501744108e-12 -GRPEL1 0.896268185523963 -ABLIM2 0.762415766797037 -HTRA3 1.71991707578293e-05 -CCDC96 2.70543466349121e-06 -CPZ 4.50799530429476e-21 -TADA2B 0.345059566153662 -WDR1 0.994593463305913 -DEFB131 0.15739801203891 -ZNF518B 0.591536151289667 -DRD5 2.52172129080646e-14 -RP11-1396O13.13 8.12517704755969e-08 -SLC2A9 1.40146196215314e-10 -BST1 2.81284355269231e-08 -LDB2 0.97606785748877 -FGFBP1 0.00103703132793641 -QDPR 0.0658164274641498 -BOD1L1 0.999528154229673 -LAP3 0.00122013401187321 -NKX3-2 0.0584925207834858 -CLNK 1.34591221879556e-20 -HS3ST1 0.00617541021258819 -FBXL5 0.977580081625291 -FGFBP2 1.14165900472648e-07 -CC2D2A 5.49406447707416e-15 -CPEB2 0.992723048645125 -PROM1 7.17058540967505e-17 -CLRN2 0.000289450029462047 -TAPT1 0.563962464646747 -C1QTNF7 0.0199101310745169 -CD38 7.65670798329562e-05 -RAB28 0.000997907226518685 -NCAPG 0.618144197205832 -PPARGC1A 0.999660628733418 -CCDC149 0.0020492844117992 -LGI2 4.4155177153273e-05 -SEPSECS 2.65169597190819e-06 -KCNIP4 0.967714666988821 -SEL1L3 0.628820331551994 -DCAF16 0.00409865973416999 -SLC34A2 1.02438347272582e-05 -MED28 0.00785226414652491 -PI4K2B 0.0426563496873728 -SOD3 0.223646616064723 -DHX15 0.999997156110677 -SLIT2 0.999999067396252 -ZCCHC4 3.21958379232717e-05 -ANAPC4 0.463847640731492 -LCORL 0.963114570470951 -PACRGL 9.13794781278667e-08 -GPR125 0.916438558188407 -KLF3 0.800390629045236 -PGM2 1.05928155018637e-12 -RELL1 0.883550395447861 -TBC1D19 0.0161012405580571 -TBC1D1 3.93946057987096e-08 -TLR10 8.43095303268399e-08 -PTTG2 0.00173161102598497 -TLR6 0.00730490768109257 -ARAP2 7.56157160220884e-13 -FAM114A1 2.38422962541873e-08 -CCKAR 0.0174084828953902 -C4orf19 0.00416046038426668 -RBPJ 0.999929168569422 -TLR1 2.02406979914294e-14 -SMIM14 0.742727362576883 -LIAS 0.0614137585139882 -CHRNA9 0.000411143835005301 -RBM47 0.958532355471074 -PHOX2B 0.850787952870986 -RFC1 0.17548740360959 -RHOH 0.123279462609065 -LIMCH1 0.999638378558411 -PDS5A 0.999852920422859 -KLHL5 0.00136508018518131 -UBE2K 0.962613421415574 -NSUN7 0.048551891347876 -KLB 0.0944730785192823 -UGDH 5.54140714269145e-05 -UCHL1 0.972670211212399 -APBB2 0.0398888659197788 -WDR19 1.73111340259862e-07 -N4BP2 0.000473118175100564 -RPL9 0.918456437508184 -TMEM156 5.76274863785555e-09 -GRXCR1 1.27110683991337e-07 -CORIN 6.35410439875821e-20 -DCAF4L1 0.851426397412879 -GABRB1 0.977782832819184 -SHISA3 0.000449561639995539 -COX7B2 0.474554621396108 -GNPDA2 0.0126461807896128 -SLC30A9 0.00142348509355749 -ATP8A1 0.999804445776751 -ATP10D 2.24183562738568e-11 -COMMD8 9.08074870529186e-07 -BEND4 0.986764685888198 -GABRG1 0.00847448373058956 -NFXL1 0.0078889795648465 -KCTD8 0.291159282160617 -GABRA4 0.981416568659062 -TMEM33 0.229168918276829 -GABRA2 0.976963701382334 -YIPF7 2.38128208040908e-05 -GUF1 2.3678005877753e-11 -ZAR1 0.0166840207254921 -TXK 1.24865833150559e-07 -SLAIN2 0.883438470234681 -RASL11B 0.290784777820631 -OCIAD2 0.00459157056484811 -DCUN1D4 0.160650285832102 -SCFD2 1.8739349735319e-06 -SGCB 0.00360015162466118 -CNGA1 5.70944542887735e-10 -FRYL 0.999999992503124 -LRRC66 9.28497779822103e-14 -CWH43 5.77317899546204e-15 -TEC 0.00257331126911319 -USP46 0.911054239074288 -FIP1L1 0.600789667366506 -SLC10A4 0.167299362234621 -NIPAL1 3.20929588480326e-09 -OCIAD1 4.71641550912238e-06 -SPATA18 1.02781168487922e-11 -NMU 0.00893184170488053 -CLOCK 0.998479650515238 -SRD5A3 0.0407270356125485 -PPAT 0.994564413329382 -PAICS 0.0683141233819019 -AASDH 2.00999745907204e-05 -PDCL2 0.0413602868128142 -GSX2 0.14870134534922 -EXOC1 0.0966642040161599 -SRP72 0.0141881388069381 -CHIC2 0.344123665599696 -TMEM165 0.94379661352925 -KIAA1211 0.130364633073797 -CEP135 4.85411343707254e-17 -KIT 0.999879540537062 -KDR 0.984488111789506 -LNX1 0.0072436266198218 -PDGFRA 0.999876729754594 -ARL9 0.397380993748074 -TMPRSS11B 1.68050228934566e-11 -YTHDC1 0.999999898691266 -HOPX 0.146965694076451 -STAP1 0.000129550414834948 -TECRL 6.39982199048601e-10 -TMPRSS11A 9.57132467628292e-11 -IGFBP7 0.00596320863879663 -LPHN3 0.999992531171852 -TMPRSS11BNL 0.315776901388964 -CENPC 0.0671173857252203 -REST 0.972672070524831 -EPHA5 0.000390070112904698 -NOA1 0.000579556702703894 -GNRHR 0.0139680451262733 -TMPRSS11D 0.0625189697700861 -POLR2B 0.988161838424889 -UBA6 0.932317516582033 -TMPRSS11F 4.97616723411608e-07 -TMPRSS11E 3.75424420546756e-05 -SPINK2 0.717781972812012 -UGT2B7 3.49679084556951e-08 -UGT2B11 3.14709815271135e-13 -UGT2A3 5.00169122908013e-06 -FDCSP 0.358744941994043 -UGT2B28 6.44395718165304e-08 -UGT2B17 0.0102556056990611 -SULT1B1 6.23606774532932e-05 -UGT2A2 2.32634948326899e-07 -HTN1 0.00180851969959408 -HTN3 0.000271792557384507 -UGT2B10 5.50615564451229e-15 -SULT1E1 7.40467355453317e-05 -CSN2 0.0588787964999457 -UGT2B15 1.92098648554063e-10 -ODAM 1.16193333896843e-13 -UGT2A1 2.73195454586815e-11 -CSN1S1 8.3001256244457e-06 -UGT2B4 8.44718840140518e-11 -C4orf40 0.00281347264227103 -STATH 0.00208280630577998 -NPFFR2 9.71482184173607e-06 -SLC4A4 0.999995794728427 -SMR3A 0.0390546471524191 -RUFY3 0.980976378677518 -MOB1B 0.00797371498062726 -CSN3 0.000194175276675009 -GC 5.77520038554047e-06 -AMTN 1.12206536324357e-06 -ENAM 5.67050431084391e-07 -IGJ 0.0048472738015348 -SMR3B 0.536532375027107 -AMBN 1.8551891948061e-05 -COX18 3.71187019873397e-05 -GRSF1 7.98241685263603e-07 -CABS1 0.0541377125884707 -ADAMTS3 1.7895345062741e-06 -PROL1 1.27720773695834e-06 -UTP3 0.00277696283555097 -MUC7 9.13857519573247e-05 -DCK 0.390659944763637 -CXCL6 0.000196265143583925 -EPGN 0.00349254550043154 -CXCL1 0.0924102929795663 -CXCL5 0.000222602233631482 -ALB 0.985726825017932 -CXCL2 0.00141254997978349 -MTHFD2L 0.000263184973008233 -PPBP 0.267236204496095 -BTC 0.116138687032558 -AREG 0.652354960633584 -CXCL3 0.0100002452503271 -AFM 2.50671195979513e-12 -PF4V1 0.00689209434338382 -AFP 4.89578911326565e-05 -EREG 0.00040011069339593 -RASSF6 1.00445854817251e-17 -ANKRD17 0.999999999649327 -PF4 0.0332968172086843 -IL8 0.000203277808854328 -THAP6 0.00144042332675322 -AC110615.1 0.00669454433694063 -USO1 0.918011905997378 -FAM47E-STBD1 1.57859436993511e-07 -CDKL2 1.86965524979377e-09 -ART3 2.26602612517891e-08 -CXCL9 0.00533395218084944 -NUP54 0.96017275018188 -FAM47E 0.341134282192102 -CXCL10 0.731025929703926 -C4orf26 0.124857081122354 -PARM1 0.00606336268651226 -SCARB2 0.072442869057668 -G3BP2 0.983145417305228 -RCHY1 0.823377800911552 -NAAA 3.31295406720326e-06 -SDAD1 3.78400058799568e-09 -PPEF2 7.34246082496395e-10 -CXCL11 0.126083380430516 -CCDC158 2.98525360726236e-13 -CCNG2 0.893204360024237 -PAQR3 0.0203917043787596 -SEPT11 0.68190156444561 -NAA11 0.00282227496929348 -PRKG2 0.449903081101253 -SOWAHB 0.00410236827486597 -FRAS1 2.28997696302965e-23 -MRPL1 3.2125698010729e-05 -SHROOM3 0.732358844454904 -ANXA3 2.04254227340065e-09 -BMP3 0.110241117911489 -CNOT6L 0.954497484149675 -ANTXR2 0.405188748060346 -CCNI 0.789094042870787 -FGF5 4.31893230685642e-05 -BMP2K 0.00191652482552986 -C4orf22 1.12464982894466e-05 -GK2 2.89758110627621e-08 -CXCL13 0.461397954954361 -AGPAT9 3.03983008533795e-09 -FAM175A 0.314878215342693 -COPS4 0.997696128383201 -HPSE 1.81464251749446e-08 -TMEM150C 0.0113392514005819 -SCD5 0.0050170857407118 -PLAC8 0.372859441505333 -ENOPH1 0.00175784115061139 -RASGEF1B 0.48852966231346 -HNRNPDL 0.916051062720941 -HELQ 4.80499059166513e-11 -LIN54 0.999433598501497 -WDFY3 1 -COQ2 0.000224020159654837 -NKX6-1 0.501554506769164 -SEC31A 0.00369934559039677 -CDS1 0.00532553324506115 -HNRNPD 0.957344185404364 -THAP9 7.47715130371729e-10 -MRPS18C 0.00897318619515012 -MAPK10 0.834149756443907 -ABCG2 1.37099444079211e-18 -DMP1 0.000223014124025285 -SPARCL1 1.07142828397564e-06 -SPP1 1.51211983311729e-06 -MEPE 0.362907708690344 -ARHGAP24 0.00469608080576638 -KLHL8 0.00120835097187105 -AFF1 0.47664697267645 -HERC6 3.19039189946829e-09 -HSD17B13 0.00195742553870655 -HSD17B11 0.000142446252538164 -DSPP 0.000618023464984046 -NUDT9 1.2725661032482e-05 -PKD2 0.995277859575451 -IBSP 7.12926740123526e-08 -PTPN13 5.05692716523618e-10 -PPM1K 0.0454661266650863 -SLC10A6 1.84221510783847e-06 -C4orf36 0.00148486509394954 -CCSER1 0.211350847441148 -BMPR1B 0.991704371391891 -NAP1L5 0.788624389923416 -GRID2 0.999998446555818 -HPGDS 8.21760977553245e-07 -HERC5 5.20637325902102e-05 -PIGY 0.106390613184656 -MMRN1 9.35082142599867e-17 -SMARCAD1 0.999996802718288 -HERC3 0.719742122657536 -PDLIM5 0.0122782806115329 -ATOH1 0.767526002722777 -UNC5C 0.0169270053737034 -SNCA 0.841962359247494 -FAM13A 2.45411477501299e-14 -TIGD2 7.02044932871713e-06 -GPRIN3 0.000266284255273368 -ADH4 7.01336073217093e-06 -TRMT10A 2.83742642062567e-05 -METAP1 0.0435476826328097 -ADH1B 0.193827609463651 -ADH1A 6.68921783131982e-08 -H2AFZ 0.855327138804775 -DAPP1 0.183493679964267 -TSPAN5 0.927948896697443 -EIF4E 0.983573342194326 -ADH6 0.00201652366064819 -ADH7 7.33278354117419e-09 -MTTP 0.0125833671870721 -C4orf17 5.65209813902781e-09 -DNAJB14 0.956254969811075 -LAMTOR3 0.68057944478499 -STPG2 1.00566542470556e-12 -PDHA2 4.51589978063264e-11 -RAP1GDS1 0.824878144875972 -ADH5 9.11477880080588e-07 -EMCN 1.65285025326724e-05 -TACR3 1.89892528244929e-06 -BDH2 4.05062122865546e-06 -CENPE 0.64584064374891 -PPP3CA 0.998148788702111 -CISD2 0.649111068534367 -MANBA 1.14972215660264e-11 -SLC9B2 0.067056661977643 -SLC39A8 0.891567478844834 -ARHGEF38 0.00563171745432905 -BANK1 1.76433043896144e-10 -TET2 7.05368251291393e-26 -SLC9B1 8.48795187528449e-05 -DDIT4L 0.000548864407256177 -INTS12 0.687399443679649 -PPA2 9.23378955160168e-06 -UBE2D3 0.748203020257397 -NFKB1 0.994260375128404 -OSTC 0.608151848832313 -CYP2U1 0.0817830150318557 -CFI 2.2377327985363e-05 -ETNPPL 0.000225469247160346 -DKK2 0.864037651771095 -CCDC109B 0.00614925695036299 -GAR1 0.812564980288159 -LEF1 0.97013467744067 -GSTCD 1.33356519642071e-07 -CASP6 0.000855157619243091 -NPNT 7.28477742725992e-06 -SEC24B 0.999867447443696 -SGMS2 0.0371284039640799 -RPL34 0.891623097197441 -COL25A1 7.11571993838381e-08 -HADH 0.000613689575050013 -AIMP1 0.000209309476432127 -PLA2G12A 0.00188156069840513 -PAPSS1 2.62383558845094e-06 -TBCK 3.2154815637914e-06 -RRH 5.10693280504954e-06 -UGT8 0.226816185725885 -AP1AR 0.511166928930552 -EGF 7.013329027337e-12 -C4orf32 0.285815911901643 -TIFA 0.118201140622243 -CAMK2D 0.016661668817136 -TRAM1L1 0.0302314470646564 -ANK2 0.999999999999808 -ALPK1 9.99914293624518e-08 -PITX2 0.672788795640444 -ELOVL6 0.97107445684069 -NDST4 0.0823391729749423 -ARSJ 0.00345579904808939 -ENPEP 3.57621192360691e-19 -LRIT3 2.23302448594056e-08 -C4orf21 2.90755164749466e-28 -NEUROG2 0.361612796522161 -LARP7 0.0150803234132968 -C4orf3 0.868030873638966 -MYOZ2 0.016734637788662 -TNIP3 0.324695186091686 -NDNF 0.152719665162684 -TMEM155 0.0012002097237969 -METTL14 0.847165775043653 -MAD2L1 0.0131674546651585 -ANXA5 3.81587630791735e-06 -CCNA2 0.994683049578133 -SYNPO2 0.737066032210172 -PRDM5 0.742419320671244 -QRFPR 1.86675403550802e-12 -FABP2 0.00117790515234333 -NDST3 0.0201167463351311 -PRSS12 4.55000945509139e-18 -SEC24D 0.00209421159390303 -EXOSC9 1.87139306709704e-06 -PDE5A 0.00339090594474959 -USP53 0.00105335346562689 -SPRY1 4.1272720246655e-05 -FAT4 0.999999998364028 -NUDT6 0.000761661984062648 -KIAA1109 3.91297690789911e-08 -SLC25A31 3.01905109757447e-06 -ANKRD50 0.918119608798956 -PLK4 0.77798174923305 -SPATA5 4.64814283804171e-10 -INTU 3.66142698703447e-07 -HSPA4L 0.0300111206441728 -TRPC3 0.000446956189740094 -IL2 0.784777636804067 -C4orf29 7.66552378708766e-07 -LARP1B 2.24164431739323e-06 -BBS12 3.92874770167448e-07 -ADAD1 0.974992286651792 -IL21 0.502190579590147 -BBS7 0.00117874565612182 -PGRMC2 0.403432082267 -MFSD8 4.66812963476778e-06 -C4orf33 0.000824304469823587 -PCDH18 0.000442524633771551 -SETD7 0.293260030580492 -ELMOD2 0.804445977851897 -PCDH10 0.894430213447045 -SCOC 0.280616505811833 -PABPC4L 0.220668248086012 -SCLT1 5.17317913653687e-12 -SLC7A11 0.000970108502996297 -MAML3 0.32989504838315 -ELF2 0.985385386978225 -MGST2 0.0551505663366712 -CCRN4L 0.520114298941272 -RAB33B 0.902062769310016 -CLGN 2.8539583939315e-07 -NDUFC1 0.459572169037874 -NAA15 0.998576839501621 -PHF17 0.982794004650508 -MGARP 0.0238241579491463 -OTUD4 0.999916478365076 -INPP4B 0.998611010146477 -MMAA 0.00318180827221776 -GAB1 0.686084015452251 -SMAD1 0.870045546037874 -HHIP 0.984617793727221 -IL15 0.917197526895697 -USP38 5.91380852389764e-05 -C4orf51 0.0151808801541665 -ZNF330 0.838316378914674 -RNF150 0.0136897522513468 -GYPE 0.00163909694496274 -GYPA 0.0153129822194926 -TBC1D9 0.876941194844605 -SMARCA5 0.999999855058167 -GYPB 0.442245534937964 -ANAPC10 0.0575682391681918 -UCP1 4.52263871484388e-08 -ABCE1 0.999982596858514 -LRBA 0.0442294366134414 -FBXW7 0.999977858674741 -DCLK2 0.966310094576242 -PRMT10 7.84047426816724e-06 -SLC10A7 0.0288074279323974 -TMEM154 0.000320382542979419 -PRSS48 0.000223313869312723 -ARHGAP10 1.21711064000628e-10 -TMEM184C 0.0175950350566643 -SH3D19 0.3750873860445 -RPS3A 0.744269730691134 -ZNF827 0.999865837850191 -NR3C2 0.925088552607185 -PET112 6.06135240467788e-10 -LSM6 0.868075946393215 -TTC29 1.57133321621439e-06 -POU4F2 0.180133325514263 -EDNRA 0.986016088385212 -MAB21L2 0.803779158934581 -FHDC1 0.024454126798477 -TIGD4 0.00192450479967101 -GUCY1A3 1.41368686812155e-06 -FGG 0.0792944198109911 -PLRG1 0.998224783427136 -RNF175 6.78625718663534e-10 -FGA 6.34645634966279e-10 -KIAA0922 0.999390132960342 -MND1 1.27812915374527e-05 -LRAT 0.0969625060475692 -FGB 0.19539017557497 -TRIM2 0.894263856491426 -RBM46 0.0203628577683536 -TLR2 9.22924764317956e-05 -NPY2R 0.188394784935151 -SFRP2 0.0538845191822357 -MAP9 5.17494979120361e-12 -GUCY1B3 0.000916633852893547 -ARFIP1 0.00372902323812407 -DCHS2 7.24816951158799e-28 -C4orf45 1.27822060379936e-05 -RAPGEF2 0.999996666741051 -NPY5R 0.491800967519258 -TDO2 1.52467035320059e-08 -GRIA2 0.99550949045347 -NAF1 0.959542886987655 -ASIC5 2.25727206903282e-07 -RXFP1 3.06530424439522e-07 -NPY1R 0.651605218674681 -FNIP2 0.997777001640614 -FSTL5 0.0025626068189185 -GLRB 0.0269281197941717 -PPID 1.70586248866827e-06 -FAM198B 2.49581508305481e-06 -ETFDH 1.63440676840321e-07 -CTSO 6.3496157062382e-06 -C4orf46 0.25900301841022 -PDGFC 0.969061048929965 -TMEM144 7.82129795001937e-08 -PALLD 6.63951548296594e-05 -CPE 0.997846906408955 -ANXA10 1.28390900106885e-08 -MARCH1 0.218777254594417 -CBR4 8.22221600155339e-06 -TRIM61 0.672137878695462 -DDX60L 8.16952566679389e-30 -SH3RF1 0.0463955276236296 -FAM218A 0.00182632450339697 -TRIM60 2.87342302842874e-07 -SPOCK3 0.495144483703879 -TMA16 0.0294700244557601 -TKTL2 8.54252539945376e-05 -DDX60 3.67465810588512e-10 -MSMO1 0.137137230699618 -TLL1 0.327496391486389 -KLHL2 0.99855485686333 -NEK1 4.21851213590427e-12 -CLCN3 0.993264929284599 -TMEM192 0.0046981347356385 -GALNT7 0.000181549323194455 -HMGB2 0.907849743135355 -ASB5 1.82587478491106e-11 -SCRG1 0.0345290274781524 -HAND2 0.351297751553542 -WDR17 7.02409304518169e-16 -GLRA3 0.0437525585382368 -CEP44 0.000569744896364766 -SPCS3 0.697040878974778 -MFAP3L 0.910529966045715 -VEGFC 0.115230709366776 -AADAT 0.250802295313827 -HPGD 0.00328250843894793 -SAP30 0.228585001159406 -GALNTL6 0.00165568126276253 -GPM6A 0.952961852044875 -ADAM29 4.69432338449837e-07 -C4orf27 0.000423306504309246 -SPATA4 0.000481541751455871 -FBXO8 0.836833761720097 -WWC2 2.48112813993575e-05 -IRF2 0.382047181106152 -ENPP6 6.11082610084163e-07 -CDKN2AIP 0.987251415538184 -RP11-389E17.1 0.0103722634244906 -CASP3 0.184808404916883 -RWDD4 0.482983522176144 -ACSL1 0.0918373313295172 -NEIL3 3.54834979186504e-07 -CLDN22 0.000437370884697617 -TRAPPC11 0.000208772147312059 -TENM3 0.999937943986087 -CLDN24 0.000259988316035725 -PRIMPOL 2.78745619908396e-13 -ING2 0.283379994488456 -AGA 0.000640803798191545 -MLF1IP 0.000144351589110452 -DCTD 1.63560551829744e-05 -STOX2 0.96321644241095 -MTNR1A 0.00303239205970951 -HELT 0.0473977091398056 -ANKRD37 0.00570485150514028 -KLKB1 4.7595385832154e-11 -FAM149A 0.00644452968141037 -SNX25 5.35420238191736e-05 -KIAA1430 0.00107217984226958 -TLR3 0.0012112447445172 -CCDC110 1.34679613842264e-08 -PDLIM3 9.36781115533718e-08 -RP11-279O9.4 0.0860375323397253 -F11 1.91287337257915e-22 -SLC25A4 0.483364232516032 -LRP2BP 1.09566990321557e-06 -SORBS2 0.0888062839921232 -UFSP2 6.10971263298467e-06 -CYP4V2 0.000200713189191236 -TRIML1 9.1739223202005e-11 -ZFP42 0.0047532978087036 -FAT1 1.77905878379738e-10 -FRG1 3.6739295210831e-06 -TRIML2 8.26179056182447e-10 -FRG2 0.431237852770668 -PDCD6 0.714212208927811 -ZDHHC11B 0.0432283730925046 -SLC6A19 8.52430000848369e-18 -PLEKHG4B 7.81216708928923e-20 -AHRR 6.76187936246612e-05 -LRRC14B 3.30673334839527e-09 -TRIP13 0.968635140819723 -ZDHHC11 5.59638555559534e-11 -SDHA 9.3872916167157e-06 -SLC9A3 0.988153998366091 -EXOC3 0.755230038369907 -SLC12A7 8.45108944554302e-11 -CEP72 1.05831804132716e-09 -BRD9 0.249187873857174 -C5orf55 0.0530820617263169 -TPPP 0.447860539159373 -NKD2 2.35583650240863e-05 -CCDC127 0.0209574915978507 -PAPD7 0.998369133901838 -CLPTM1L 0.311319339054671 -C5orf49 0.346800140585866 -NSUN2 0.961845836118256 -SLC6A18 1.67091561448187e-22 -NDUFS6 0.00026220073529281 -ADAMTS16 0.00108650288416212 -C5orf38 0.162071502267242 -SRD5A1 1.81750169865493e-06 -IRX1 0.00231065420659156 -TERT 0.866151189063377 -KIAA0947 0.999997609908876 -MRPL36 0.254818113331356 -IRX2 0.648697596940709 -MED10 0.0397210577852175 -LPCAT1 0.813682374432471 -IRX4 0.25376901140337 -ADCY2 0.999995485664533 -SLC6A3 0.99703690247797 -TAS2R1 0.241581130135791 -TRIO 0.999999999999911 -CTNND2 0.999999951944472 -ROPN1L 0.00163543636221054 -DNAH5 5.78867795702671e-37 -ANKH 0.167376865709729 -CMBL 0.00776530380841664 -MTRR 4.10850052026828e-07 -CCT5 0.998786782216759 -FASTKD3 2.49269112263401e-10 -MARCH11 0.0024662431250002 -FAM173B 2.44499722250718e-07 -FBXL7 0.200106851536876 -SEMA5A 0.000979594322677327 -MARCH6 0.999995976388274 -FAM105A 2.32580771885254e-07 -DAP 0.000324904230614164 -FAM105B 0.969681278249237 -MTMR12 0.997884435033356 -AC026703.1 0.451936607798932 -SUB1 0.800760313727209 -CDH6 0.980834799201761 -PDZD2 0.999645170986495 -TARS 1.18541739422624e-09 -BASP1 0.539222352506789 -CDH18 0.463926460278232 -CDH9 0.992483590378092 -FAM134B 0.00565139603237414 -PRDM9 1.9533397375621e-22 -CDH10 0.309152977089917 -ZFR 0.999999670342593 -CDH12 0.00145119382648096 -ZNF622 0.0888038528384209 -GOLPH3 0.0143654910992665 -MYO10 0.00396952046057879 -NPR3 0.00309926266837596 -DROSHA 0.99639964840206 -C5orf22 0.169565363421206 -ADAMTS12 1.53777100809711e-11 -SKP2 0.9942587612668 -SLC45A2 7.85681140165749e-05 -C1QTNF3 0.000296343818969862 -PRLR 0.916128016014322 -NADK2 0.90764788651388 -CAPSL 0.000440614569244343 -IL7R 3.72072117299544e-06 -TTC23L 2.21738028334575e-09 -UGT3A1 5.21347442389169e-10 -RXFP3 2.31380740273664e-11 -AMACR 0.125255655188202 -UGT3A2 2.94297254099195e-10 -LMBRD2 0.0145652183487776 -AGXT2 4.66554613813699e-15 -RAI14 0.487656416164767 -RAD1 0.000186646011793966 -BRIX1 0.981126894231147 -DNAJC21 1.4512199767017e-05 -SPEF2 2.02916164361718e-16 -PTGER4 0.896912956538018 -NUP155 0.990594276419902 -PRKAA1 0.0351010343853684 -TTC33 0.0226185448110003 -SLC1A3 0.432519796435931 -C9 6.82499306595342e-17 -DAB2 0.980417113899471 -RICTOR 0.999999999869293 -EGFLAM 9.38438550961537e-10 -RANBP3L 1.13183444081718e-10 -NIPBL 1 -C5orf42 6.320876617357e-19 -FYB 0.792005858585418 -LIFR 0.00100684330037545 -RPL37 0.577671288406045 -CARD6 1.45631048490053e-16 -GDNF 0.698672292120293 -OSMR 3.10306262078619e-11 -WDR70 0.802235272890051 -SEPP1 3.00317467343857e-08 -GHR 0.000232177140704853 -FBXO4 7.10839893911415e-05 -MROH2B 1.28868466121395e-26 -NNT 0.99955047731355 -C5orf28 1.49355055551377e-05 -C5orf51 0.00388889950519938 -NIM1 5.80877563098536e-09 -ANXA2R 3.08027490605399e-06 -C7 1.26145650921317e-11 -ZNF131 0.999460221505131 -CCL28 0.281065700553635 -HMGCS1 0.972848684238687 -C5orf34 9.91326958657609e-11 -PAIP1 0.994278972453478 -C6 1.2016606841251e-14 -PLCXD3 0.0484887392356897 -OXCT1 0.267382736691876 -FGF10 0.858814551551722 -HCN1 0.953138502832124 -NDUFS4 0.00416499574013875 -HSPB3 0.000440374165595957 -PARP8 0.119242934394393 -SNX18 0.146597452225803 -ITGA1 0.00237568458237799 -CDC20B 1.44458294596898e-11 -MOCS2 0.0404518496138402 -ESM1 0.0261762175615844 -GZMA 3.24372441390747e-07 -EMB 6.39337047960594e-05 -FST 0.963797331589925 -PELO 0.590624888783281 -MRPS30 5.58147796749342e-05 -ISL1 0.606135790074323 -GZMK 0.000569041450124066 -ARL15 0.00886642197401129 -ITGA2 9.23087390177119e-09 -IL31RA 2.13041261180957e-15 -DHX29 0.00352731615478607 -SLC38A9 0.755167399338962 -SETD9 0.000533497554716758 -PPAP2A 0.799472951883635 -ACTBL2 6.02234434562323e-10 -MIER3 0.999216429515142 -PLK2 0.998863614916352 -GPBP1 0.975851112431475 -ANKRD55 2.4350104791824e-07 -IL6ST 0.997842778499494 -CCNO 0.0407101250551045 -DDX4 0.998516038315595 -SKIV2L2 0.725400924600165 -GAPT 0.00163093337057768 -GPX8 0.0190662288898625 -MAP3K1 0.998072118460426 -FAM159B 0.101184301652243 -KIF2A 0.999339688994676 -SMIM15 0.228320204389897 -ZSWIM6 0.330184633856795 -PDE4D 0.983199686418857 -RGS7BP 0.978832467535271 -RNF180 5.17341244679766e-05 -IPO11 0.996456954689181 -RAB3C 0.015496264062785 -C5orf64 0.0411009097234592 -ERCC8 8.5728345941739e-09 -HTR1A 0.926694462856279 -NDUFAF2 3.85650772594405e-07 -DIMT1 1.47117897450072e-05 -DEPDC1B 2.28513658245294e-05 -ELOVL7 0.00156092226554038 -TRAPPC13 0.765500289091919 -MRPS36 0.746558796887922 -NLN 3.59597227684907e-07 -SGTB 0.991633522582233 -CWC27 1.01532147516582e-05 -PIK3R1 0.998240487886569 -TRIM23 0.0669671844650749 -ADAMTS6 0.998800472645028 -SREK1 0.98837347237608 -CENPK 1.66228604969503e-08 -MAST4 0.00813023877986137 -SREK1IP1 0.656016357375955 -ERBB2IP 0.993356911851659 -CCNB1 0.0239694449209668 -CD180 1.35095566898906e-05 -PPWD1 0.0317857747802877 -CENPH 7.52859796072614e-05 -SLC30A5 0.230512231685005 -ZNF366 0.504819503691726 -CDK7 0.00161852539016363 -RAD17 0.00769743491101139 -SMN1 0.10097186938376 -GTF2H2 0.724561788823269 -MCCC2 4.09035244002361e-08 -TAF9 5.73990719710396e-05 -OCLN 0.491025450228121 -MAP1B 0.999986247796098 -NAIP 0.000869318190199381 -CARTPT 0.420347162514966 -CCDC125 8.05457406388208e-06 -SMN2 0.0952559827908932 -BDP1 4.37097990000324e-11 -MRPS27 0.0285866865587268 -MARVELD2 4.23034393772305e-11 -GTF2H2C 0.89190553150668 -PTCD2 3.49480168983275e-08 -TNPO1 0.999998700726593 -UTP15 0.985835503072082 -ARHGEF28 1.82695073178584e-10 -ENC1 0.879896897082265 -GFM2 1.22849095804363e-08 -FCHO2 0.999038489396249 -POLK 5.99896012883471e-07 -BTF3 0.904371539633102 -COL4A3BP 0.979474243191344 -NSA2 0.686235240727363 -TMEM174 0.0152558855768961 -HEXB 1.49158509655983e-05 -ANKRA2 0.0035050375875932 -TMEM171 0.000165604398072204 -HMGCR 0.999836644997739 -GCNT4 0.0212350420721519 -FAM169A 0.998576224772368 -F2R 0.0412384876728322 -IQGAP2 4.102950079501e-15 -LHFPL2 0.0150144683952531 -POC5 0.00213816175598754 -AP3B1 0.995386030171841 -F2RL2 7.36707093228916e-07 -TBCA 0.716435529155031 -BHMT2 2.73916876646438e-12 -CRHBP 0.989594470418958 -ARSB 0.00126175276165402 -F2RL1 0.00202251710092648 -WDR41 2.51915134260848e-06 -SCAMP1 0.842276280270073 -PDE8B 0.986862335777411 -ZBED3 0.0784364357896077 -DMGDH 8.90328276029772e-17 -AGGF1 6.09962982121775e-05 -S100Z 0.00959470303590954 -SV2C 6.35694393316701e-05 -OTP 0.848003249176535 -ZFYVE16 1.30484002602704e-08 -CMYA5 3.80676086686769e-43 -FAM151B 8.20978463368662e-07 -SSBP2 0.976772519033216 -HOMER1 0.995922024391312 -JMY 0.999722637107555 -SPZ1 0.0015105932431128 -PAPD4 0.000956870232763351 -ACOT12 1.28596440526683e-11 -ANKRD34B 2.52690094900488e-09 -CKMT2 7.87308868812856e-10 -MTX3 0.10035111705881 -SERINC5 0.000839904080638089 -BHMT 0.000316952447729784 -RASGRF2 0.998743353862856 -MSH3 4.56585570518733e-23 -THBS4 1.74208249337707e-08 -ZCCHC9 0.00747394820991637 -DHFR 0.276594317743087 -CETN3 0.0113207798625902 -VCAN 0.999750597976069 -ARRDC3 0.978746961781062 -RASA1 0.999998285566451 -MBLAC2 0.000280100214502958 -CCNH 0.00472976282475442 -ATG10 0.00168505422151429 -MEF2C 0.00424617418418377 -COX7C 0.545791853002404 -TMEM161B 0.00368500214116822 -GPR98 8.11098418587805e-24 -XRCC4 0.00125064277988027 -HAPLN1 0.260833364813835 -RPS23 0.878578937888168 -POLR3G 6.42759125510305e-05 -EDIL3 4.08771487713601e-05 -TMEM167A 0.388457895130387 -LYSMD3 0.771815089892096 -ATP6AP1L 0.139629451145235 -GPR150 0.00224716234978038 -MCTP1 0.00988911824115707 -GLRX 0.000187398851916141 -KIAA0825 4.26150495630825e-07 -ELL2 0.99828854499778 -PCSK1 0.0896398214145992 -RHOBTB3 0.000533732466857457 -RFESD 0.000253687867229454 -TTC37 7.99341870810084e-20 -ARSK 0.00461420992933416 -ERAP1 9.99009541070118e-18 -FAM172A 0.0182871087954041 -ANKRD32 0.00364190299939628 -FAM81B 5.11790785662586e-06 -CAST 1.55575755785131e-06 -SPATA9 0.00218974170250578 -POU5F2 0.00100875260505586 -LNPEP 0.998308425894494 -RGMB 0.0607554230019872 -RIOK2 0.00114011174991567 -LIX1 0.0166746879363502 -PPIP5K2 4.05311854851164e-10 -ERAP2 3.18437372981209e-22 -CTD-2215E18.1 2.43899077768921e-05 -FBXL17 0.977900472361054 -FAM174A 0.000618293705839529 -NUDT12 3.27725302698986e-11 -ST8SIA4 0.675929296308764 -EFNA5 0.889436552296034 -FER 0.968420467139565 -CHD1 0.999999999362856 -C5orf30 0.778880851929595 -SLCO6A1 2.70904557113252e-06 -PAM 0.0304443970438953 -GIN1 0.00667768191022757 -SLCO4C1 1.37231076325155e-06 -APC 0.999999927739402 -SRP19 0.0852679958175839 -SLC25A46 0.00117611684259399 -EPB41L4A 1.98631994116418e-11 -NREP 0.563643143236761 -PJA2 0.466603861583053 -ZRSR1 1.30572509036053e-05 -REEP5 0.0628875963888091 -DCP2 0.856306644918669 -MAN2A1 0.0186444331521237 -CAMK4 0.0158296697612448 -MCC 2.25777940265897e-08 -TSSK1B 0.000465467839899368 -STARD4 2.95656598761803e-07 -YTHDC2 0.999999571704339 -TSLP 0.0447881738846191 -WDR36 0.544023667237535 -AP3S1 0.00185372377308681 -CCDC112 0.821147626124143 -CDO1 0.0200728003981878 -TNFAIP8 0.239737016503802 -TMED7-TICAM2 0.00470963741298361 -COMMD10 7.83686369938315e-06 -TRIM36 0.000675729869239821 -PRR16 0.52619928151234 -PGGT1B 0.625204501483712 -SEMA6A 0.999546536591411 -FEM1C 0.624676084568469 -DTWD2 2.16048560607966e-05 -HSD17B4 1.82463226929793e-05 -DMXL1 0.999998843167901 -TICAM2 0.00470963741298361 -KCNN2 0.971048688574044 -AQPEP 2.72895123983059e-09 -ATG12 0.00165807110195777 -TMED7 0.363701354530081 -CEP120 4.34470692506916e-11 -C5orf48 0.00517878083539121 -SNX24 0.00139280727569243 -FTMT 0.0816239867421276 -GRAMD3 1.53546581217794e-07 -ZNF474 5.66230084983659e-07 -ALDH7A1 1.95312955165253e-12 -LOX 0.97935777427103 -SNCAIP 0.000362967804998999 -PHAX 0.00269319619944417 -ZNF608 0.999968158467997 -LMNB1 0.952857388391862 -SNX2 0.99794124167631 -PPIC 0.000967993093039106 -MARCH3 0.636727871339738 -CSNK1G3 0.996751666329429 -MEGF10 0.994324945081641 -SRFBP1 8.19334299777791e-05 -SLC12A2 0.999438621805128 -FBN2 0.999999991794472 -PDLIM4 0.924088701530717 -CTC-432M15.3 0.996763358307615 -ACSL6 0.088562272207543 -LYRM7 0.0135019993167191 -FNIP1 0.99981944509088 -HINT1 0.0842644971048886 -ADAMTS19 0.951958940870202 -CDC42SE2 0.753728627374484 -CTXN3 0.544481267710668 -SLC27A6 2.858831106907e-09 -CSF2 0.803849286352491 -PRRC1 2.13078587199281e-05 -CHSY3 0.011861287143968 -P4HA2 6.46128411074688e-05 -IL3 3.72135953228091e-09 -RAPGEF6 0.998026273148455 -ISOC1 0.00529303405400188 -C5orf56 0.107649237505837 -RAD50 3.45027967852237e-15 -LEAP2 0.00789837798993102 -CCNI2 4.53255419093452e-05 -ZCCHC10 0.16080191147859 -SHROOM1 0.00959554880204162 -IL4 0.168021415276942 -HSPA4 0.999958225713848 -KIF3A 0.992416127781631 -SLC22A5 4.90000271154311e-09 -IRF1 0.867788618113854 -FSTL4 0.981626121203096 -GDF9 1.19472233006091e-05 -AFF4 0.999997450786603 -IL13 0.0257146912157871 -IL5 0.0283744149089649 -SLC22A4 4.64079476855844e-06 -SEPT8 0.954285718069544 -UQCRQ 0.0919129783108912 -PHF15 0.999310487478193 -UBE2B 0.320977558728882 -SKP1 0.224830619473668 -PITX1 0.273516400735677 -TCF7 0.361554570284009 -CDKL3 4.32898502493702e-07 -PCBD2 0.00306259643722676 -CATSPER3 0.000487201544072685 -C5orf24 0.640813736011774 -CAMLG 0.00402053963029354 -C5orf15 0.0159999377606089 -CTC-349C3.1 0.00111546783951847 -CDKN2AIPNL 0.0582451914681328 -DDX46 0.999997754157555 -H2AFY 0.795089570241366 -SAR1B 0.00630041605283772 -PPP2CA 0.985509347938547 -TXNDC15 0.109182712654528 -VDAC1 0.975595138410154 -SEC24A 1.31213682191576e-05 -MYOT 2.64170747311334e-05 -SMAD5 0.986055593220514 -KIF20A 1.91703489767524e-08 -CXCL14 0.0227861893272512 -HNRNPA0 0.863701458346368 -PKD2L2 3.49693117527093e-07 -KLHL3 0.924154761446343 -NEUROG1 5.1362785698948e-05 -FAM13B 0.900071909481818 -TIFAB 1.15428409214873e-06 -TRPC7 0.00298615175665186 -IL9 0.000540879665166309 -C5orf20 0.00255118373262747 -SPOCK1 0.320886444579516 -SLC25A48 0.3910144779106 -BRD8 0.000590819287003113 -LECT2 0.00580249401291057 -WNT8A 0.875728925683611 -TGFBI 0.00372244046527813 -NME5 0.570640716006077 -SLC23A1 0.0243223058859264 -EGR1 0.674344947164404 -HSPA9 0.981119322463888 -CDC23 0.999307693129197 -REEP2 0.876388829269941 -TMEM173 0.0323306205833744 -DNAJC18 0.00546933470257871 -CTNNA1 0.970554290062812 -KDM3B 0.999999999078234 -PAIP2 0.79947261034215 -GFRA3 0.0290609621761813 -MATR3 0.999818897618359 -ETF1 0.998925127429319 -CDC25C 3.00948392905045e-08 -FAM53C 0.639249208225445 -MZB1 0.0038114549410852 -SIL1 0.000933875133307504 -LRRTM2 0.923558761887084 -CYSTM1 0.284309259662413 -NDUFA2 0.339536516355874 -UBE2D2 0.945312660180096 -CXXC5 0.79535527912222 -NRG2 0.995154288008006 -IK 3.47058187314951e-06 -PSD2 0.180222827298736 -IGIP 0.41991884415955 -APBB3 1.54051117620328e-05 -PFDN1 0.805475103411555 -SLC4A9 5.6907011258673e-18 -EIF4EBP3 0.0542430246091404 -PURA 0.845099483885208 -SRA1 5.00127987809857e-06 -HBEGF 0.830814322298121 -SLC35A4 0.000744268610339096 -ANKHD1-EIF4EBP3 0.999999999937697 -ANKHD1 0.999999999937697 -TMCO6 8.14596215918246e-06 -CD14 6.68636589803062e-05 -DND1 0.709666236197164 -PCDHA9 7.8893945081967e-14 -PCDHA12 3.51762607400118e-10 -HARS 0.000736050889038717 -PCDHA10 4.18271816069149e-11 -PCDHA6 6.16174888872113e-08 -PCDHA1 0.000559474715442591 -PCDHA7 0.000137151933946153 -PCDHA11 3.59325181225576e-10 -PCDHA3 1.46196613178525e-13 -PCDHA8 3.70119875231036e-10 -PCDHA4 2.8753730977395e-15 -WDR55 1.48298652018262e-06 -PCDHA13 4.28546861491057e-11 -HARS2 8.12767561165649e-05 -AC005609.1 0.0330363485865677 -PCDHAC1 4.57699170322582e-09 -PCDHA2 1.98580542965182e-09 -PCDHA5 0.00353824820282254 -ZMAT2 0.971433760073875 -PCDHB13 1.69139790303478e-09 -PCDHB7 1.30423838331795e-15 -PCDHB8 4.79968959397036e-08 -PCDHB6 0.00172664093496475 -PCDHB1 2.81493692972867e-08 -PCDHB16 0.00177081504936022 -PCDHB17 0.0302156622505593 -PCDHB11 3.09017538885927e-07 -PCDHB5 9.45268553121999e-07 -PCDHB15 0.00680082460641515 -SLC25A2 0.0365973537230041 -PCDHGA1 0.000268173566278005 -PCDHB14 9.0591236628607e-09 -PCDHB10 1.17632278967153e-06 -PCDHB12 0.000155401804648917 -TAF7 0.736629403611825 -PCDHAC2 0.916966111870881 -PCDHGC4 0.93614957487166 -PCDHGB7 0.0160706258502221 -PCDHGA6 8.20064599747487e-07 -PCDHGC3 0.705736988755585 -PCDHGA8 9.44701125840242e-09 -PCDHGC5 2.85043689391107e-05 -PCDHGA11 4.54527989298976e-05 -PCDHGB6 6.46505596680808e-05 -PCDHGA10 5.44479549104987e-06 -PCDHGB2 3.5428979703809e-07 -PCDHGA3 0.000592397328401253 -PCDHGA5 0.000468775328634083 -PCDHGA12 0.00072767906356036 -PCDHGA9 3.67577801365825e-05 -PCDHGB1 0.168083945130884 -PCDHGB4 0.00256131629310045 -PCDHGA7 5.27648432399162e-06 -PCDHGB3 0.000624134619793241 -PCDHGA4 5.9646129412289e-07 -PCDHGA2 8.23180823080115e-07 -GNPDA1 0.00342635564065799 -PRELID2 1.73073934677441e-05 -SH3RF2 1.79074374939974e-11 -HDAC3 0.955038023763879 -KCTD16 0.959972607609424 -RELL2 0.800132420991145 -PCDH12 1.29394215809467e-10 -PCDH1 0.87319543986175 -ARHGAP26 0.998859800147404 -FCHSD1 1.92350768763502e-16 -RNF14 0.00753476991397154 -DIAPH1 0.267109674008721 -KIAA0141 3.06120841888116e-10 -ARAP3 0.967505028947346 -YIPF5 0.931585721197837 -GRXCR2 1.74530955295463e-05 -FGF1 0.320471735942387 -NDFIP1 0.920196502722478 -NR3C1 0.311618465710419 -SPRY4 0.109919685601811 -SPINK13 0.0243569531155143 -C5orf46 0.29942489197858 -PLAC8L1 0.13237785518608 -SPINK9 0.326828103280709 -RBM27 0.999999942051571 -POU4F3 0.721115139448867 -GPR151 1.05612992862494e-05 -TCERG1 0.999962712136281 -DPYSL3 0.996483173643699 -JAKMIP2 0.999936528336512 -FBXO38 0.999962180270506 -SCGB3A2 0.0424274770547476 -SPINK5 2.116589476282e-17 -SPINK6 2.41645569954461e-05 -SPINK1 0.293111298714489 -SPINK7 0.0761167144856102 -PPP2R2B 0.900682516546481 -LARS 2.27045044262368e-05 -SPINK14 0.0163521578795306 -STK32A 5.72450465710222e-05 -SH3TC2 1.73290380655384e-12 -PDE6A 6.60508610952056e-12 -PCYOX1L 1.26712222774021e-05 -CDX1 0.702597062757003 -IL17B 0.00207428402959818 -SLC26A2 2.16616893086973e-05 -ADRB2 0.476493104047244 -HTR4 0.648787512759024 -AFAP1L1 4.06878415314462e-08 -GRPEL2 0.00575467231542279 -TIGD6 4.86406711005621e-06 -CAMK2A 0.998004220808766 -SLC6A7 7.14638706508392e-06 -ABLIM3 0.0160253493614536 -CSNK1A1 0.993657229734498 -CSF1R 0.993497648111379 -PPARGC1B 0.934054614318936 -PDGFRB 0.998643465625158 -ARHGEF37 1.08240046485854e-13 -SLC36A3 1.18609331200363e-06 -SYNPO 0.980249084871384 -AC010441.1 0.00461285721530898 -ZNF300 0.000952650554439373 -ARSI 1.05161485653303e-09 -NDST1 0.998138371728285 -GM2A 0.111186454530615 -SLC36A2 1.41130186369675e-06 -TNIP1 0.929689199234392 -SMIM3 0.00149206539766125 -CCDC69 3.78649706533996e-08 -RPS14 0.864815342185179 -RBM22 0.995946455694191 -TCOF1 0.765232862711561 -MYOZ3 0.346673295762729 -ANXA6 0.000183002363281359 -DCTN4 0.953389997662452 -GPX3 0.0155826368713898 -CD74 0.0500580580449508 -ATOX1 0.17740157925531 -HAND1 0.0695994741559291 -SGCD 0.00233910042363156 -FAXDC2 1.47672397769909e-06 -MFAP3 0.00844477902532272 -SLC36A1 0.0234724316059047 -CNOT8 0.675125645478961 -FAM114A2 3.07870322878957e-07 -G3BP1 0.98839076401586 -MRPL22 3.44167883429456e-07 -NMUR2 0.421657260997351 -SPARC 0.886494106065438 -GLRA1 0.0764924553316808 -FAT2 7.35015824204342e-11 -GEMIN5 3.13420201203131e-14 -GALNT10 0.000449260379215831 -LARP1 0.9999521889832 -GRIA1 0.999436340840325 -KIF4B 3.11373152293453e-19 -SAP30L 0.857185856481165 -FAM71B 0.00232967390794607 -ADAM19 4.20155244794664e-06 -LSM11 0.490844531335381 -IL12B 0.000223245843678324 -HAVCR1 0.00305433633416917 -ADRA1B 0.182479134837027 -THG1L 3.48304059537209e-05 -UBLCP1 0.118128583459485 -TIMD4 4.33746964441321e-08 -CYFIP2 0.999998602593714 -ITK 1.49550808638438e-05 -SOX30 0.998986334267771 -FNDC9 0.00399382359916547 -MED7 0.215739810584496 -NIPAL4 0.000898828686270022 -HAVCR2 0.111384118892431 -EBF1 0.996264496901181 -RNF145 0.663621979090798 -CLINT1 0.800888476219691 -TENM2 0.999951089930002 -NUDCD2 0.000812082193063064 -WWC1 0.0183845063096721 -HMMR 1.03956948492903e-14 -TTC1 0.00185167699732794 -PTTG1 0.169726364244784 -C1QTNF2 0.00135853504128362 -CCNG1 0.359162745208338 -GABRA6 9.41937064600856e-08 -GABRA1 0.963866034985763 -RARS 0.000533649935549474 -FABP6 0.000205946389112365 -C5orf54 0.000364084044826785 -SLU7 0.000115176106946952 -GABRG2 0.958543398155425 -PWWP2A 0.920215651464739 -GABRB2 0.940299230468594 -MAT2B 0.252497397412429 -CCNJL 1.94749657136305e-05 -ATP10B 1.3436999038052e-23 -PANK3 0.000282412768333647 -STK10 1.50167370249254e-07 -DOCK2 0.999999892553994 -LCP2 0.988900379914002 -NPM1 0.959043977290382 -C5orf58 0.0389421300224031 -RANBP17 8.61017652515499e-36 -FOXI1 0.109581473399305 -KCNIP1 0.0202319565749317 -SLIT3 0.991788383605727 -TLX3 0.302655050937496 -GABRP 9.63031365626368e-06 -SPDL1 8.71550549150675e-10 -FGF18 0.175827312241956 -FBXW11 0.997161483868132 -KCNMB1 2.07038513299084e-05 -NSG2 0.799823217857166 -DRD1 0.896431549924012 -SH3PXD2B 0.0185367927997724 -NEURL1B 0.370536573297444 -BNIP1 0.00143692768334693 -MSX2 0.42149241575751 -SFXN1 0.58517754975236 -CPEB4 0.996854727820052 -BOD1 0.031829615385069 -RPL26L1 0.492260269694433 -NKX2-5 0.858647741285937 -HRH2 0.83527325871176 -CREBRF 0.998406138401379 -UBTD2 0.748758501654584 -STC2 0.453518117972185 -ATP6V0E1 0.277597261020232 -ERGIC1 0.714836766400926 -DUSP1 0.0205002018825111 -SNCB 0.198196528468429 -TSPAN17 1.31977556559059e-05 -UNC5A 0.996259997309535 -UIMC1 0.0326458625692234 -FAF2 0.998046615446585 -GPRIN1 0.787287341879441 -CLTB 0.115492460175414 -SIMC1 0.000207486981163 -CPLX2 0.717836321082537 -CDHR2 6.36801969145907e-10 -KIAA1191 0.00156087265921572 -EIF4E1B 0.111053691650741 -NOP16 0.145044756925216 -HIGD2A 0.238671224285494 -FAM153B 0.647490029033932 -ARL10 4.90395449664771e-05 -RNF44 0.56792965822815 -HK3 1.15547608704236e-14 -RAB24 0.725032093168432 -TMED9 0.159567867411613 -F12 3.46472901004721e-06 -MXD3 0.00156992894615881 -DOK3 7.27877709275655e-05 -PRR7 0.72498912624669 -RGS14 0.0231115520177416 -SLC34A1 1.07656497406863e-15 -PDLIM7 0.903030194388649 -LMAN2 0.0500442996260229 -PRELID1 0.865363911946567 -FGFR4 1.30017490282e-06 -FAM193B 0.923710453002021 -PFN3 0.519957351463764 -DBN1 0.962685618555225 -NSD1 0.999999999179163 -DDX41 0.000984379620636701 -GRK6 0.248841091131392 -ZNF346 0.782525684649077 -B4GALT7 0.00319749562629115 -ZNF354A 0.000195110610594158 -N4BP3 0.276863142105786 -ZNF454 4.44345719446746e-05 -COL23A1 9.57449236414112e-10 -ZNF354C 0.000135489022139871 -ADAMTS2 0.992213475206961 -RMND5B 6.92213346694124e-08 -NHP2 0.0342616850367737 -RUFY1 0.0646702146609533 -PHYKPL 1.72748794347931e-10 -ZFP2 5.6203288384679e-12 -FAM153A 0.276667825081711 -ZNF879 0.000705395855764813 -ZNF354B 1.96076723041207e-05 -PROP1 0.299126611004975 -FAM153C 0.848853442214669 -GRM6 2.41818920529745e-09 -CLK4 0.449835920959239 -HNRNPAB 0.960162611643984 -LTC4S 0.00216910624326774 -SCGB3A1 0.452637901767245 -CANX 0.86247386009449 -SQSTM1 0.00353899119164032 -CNOT6 0.478458001419819 -FLT4 0.999936678740361 -MAPK9 0.00956433819094729 -MAML1 0.998362055817934 -RASGEF1C 0.00331810036135796 -TBC1D9B 1.4941078717937e-07 -GFPT2 6.62530503452039e-07 -OR2Y1 5.15790392859341e-07 -HNRNPH1 0.99914829403982 -C5orf45 3.28629116657157e-06 -MGAT4B 0.813383750750224 -MGAT1 0.690362903375764 -RNF130 0.864935169465201 -TRIM41 0.965388635580126 -BTNL9 6.53404156111455e-10 -TRIM7 0.0659400780546186 -TRIM52 8.08204670688077e-06 -BTNL3 0.0396371481687155 -ZFP62 0.115212077093719 -BTNL8 0.000235087769484238 -GNB2L1 0.994631521397633 -OR2V2 0.225731243700957 -OR2V1 1.7436947905009e-08 -SERPINB1 0.0203430155859586 -BPHL 0.000194971395463508 -SERPINB6 0.0356687992106553 -MYLK4 1.65850133719676e-11 -EXOC2 0.000114966062554538 -NQO2 1.26932724907491e-05 -GMDS 0.997690128557445 -IRF4 0.922220690010892 -SERPINB9 0.00489853442133744 -C6orf195 0.00344852669127423 -RIPK1 0.418177400187703 -DUSP22 0.00430707145380812 -HUS1B 0.00831323325620067 -WRNIP1 0.637334638091566 -RREB1 0.999967927968287 -F13A1 0.00102736089825156 -PXDC1 0.550017216808143 -FAM217A 1.67423776229135e-06 -NRN1 0.823897693087707 -RPP40 0.00257720793912516 -PRPF4B 0.999999729158495 -LY86 9.98061892056217e-06 -SLC22A23 0.366550902975159 -C6orf201 0.0922482847224992 -CAGE1 2.62440972757105e-06 -FARS2 4.54145794820807e-06 -SSR1 0.0322896005433474 -FAM50B 0.195542493403811 -LYRM4 0.0402580402942408 -ECI2 3.83619595564471e-09 -CDYL 0.946570708320529 -TXNDC5 1.78543371790755e-06 -SYCP2L 4.34413935048992e-11 -SNRNP48 7.93003716284965e-05 -BLOC1S5 1.60196837053719e-05 -SLC35B3 0.00056646400612064 -GCM2 0.00140119057160784 -RIOK1 8.13737884500142e-07 -PAK1IP1 0.368163912185113 -DSP 0.999901542789998 -ELOVL2 0.000198697181598092 -TMEM14B 6.47506816571318e-07 -MAK 9.62965218458322e-11 -TFAP2A 0.987223276135779 -BMP6 0.895081718104266 -EEF1E1 0.553269942523892 -GCNT2 0.0193977222149499 -TMEM14C 0.121418783802206 -GFOD1 0.0496190699820879 -RANBP9 0.999958495559594 -PHACTR1 0.664117315162539 -CD83 0.0177806863985442 -MYLIP 0.020226886854297 -SIRT5 1.87753474665446e-05 -HIVEP1 0.999986917229393 -JARID2 0.999862193011047 -DTNBP1 1.33929654176623e-06 -AL583828.1 6.68248157406909e-05 -TBC1D7 8.3011606302466e-06 -ERVFRD-1 0.00242834562362554 -ADTRP 0.000702618266442128 -AL441883.1 0.008076217272729 -NEDD9 0.534981125014028 -MCUR1 0.00156303078281646 -TMEM170B 0.674229051511487 -EDN1 0.0810200671130622 -RNF182 0.0120687768208081 -NOL7 0.0109601211451256 -GMPR 0.00252568644042527 -RBM24 0.196222354193918 -RNF144B 0.0276377158382251 -SOX4 0.384005969080463 -MBOAT1 8.84450886798244e-07 -TPMT 7.57391771227039e-05 -HDGFL1 0.313343421346475 -DEK 0.102359186951826 -ID4 0.149454865643541 -ATXN1 0.398661149433984 -KDM1B 0.815087936736707 -NHLRC1 0.0360065335308677 -KIF13A 0.999958505813411 -CDKAL1 0.577650480843115 -PRL 0.00264110170025645 -E2F3 0.84245784569691 -FAM8A1 0.170367796343802 -NUP153 0.999994457328352 -CAP2 0.410487087790501 -KAAG1 0.0191912389509573 -LRRC16A 0.502318842467879 -SLC17A3 9.88205561287661e-14 -FAM65B 0.971310088681335 -NRSN1 0.00430725148247795 -GMNN 0.607453614744368 -KIAA0319 7.95792630986591e-12 -GPLD1 5.63947612847098e-09 -ALDH5A1 0.00290426169695016 -SLC17A1 2.59261497697838e-10 -HIST1H2BA 0.132823726172591 -HIST1H2AA 0.00086097937187989 -SLC17A4 6.33422534991957e-06 -ACOT13 3.42929947285046e-05 -C6orf62 0.946557424258141 -MRS2 8.84583170646535e-05 -SCGN 0.0359460022848758 -DCDC2 1.04848738314639e-05 -TDP2 0.000137008141135578 -HIST1H2BD 0.000277979441009119 -HIST1H4A 0.00228540295756206 -SLC17A2 0.00466985446742192 -HIST1H4B 0.00854182671998013 -TRIM38 4.75130205096512e-06 -HIST1H3C 0.215540519058334 -HIST1H2BE 0.000307871828087192 -HIST1H2BB 0.130327871216174 -HFE 8.4969700310781e-07 -HIST1H1A 0.00353079926543669 -HIST1H2BC 0.00287801155749555 -HIST1H2AB 0.00531944331445787 -HIST1H4D 0.00226430020608533 -HIST1H2AC 0.599175549394101 -HIST1H4C 8.85616839210981e-05 -HIST1H3A 3.98008178767139e-05 -HIST1H3B 0.307282993148648 -HIST1H2BG 2.94452400546665e-06 -BTN3A2 0.000124518814289725 -HIST1H2BH 0.000295729876724394 -BTN2A1 1.07467588553941e-18 -HIST1H2AD 3.99677268819075e-05 -HIST1H4G 0.00262999657981332 -HIST1H4F 0.181985150966619 -HIST1H2AE 0.62412365369502 -BTN3A1 8.65113669435817e-07 -HIST1H2BI 0.138012141980387 -HIST1H4H 0.00879032933359599 -BTN3A3 7.19024879190517e-10 -BTN2A2 0.000150288420483044 -HIST1H4E 0.000642250549090646 -HIST1H3E 0.000813428842528686 -HIST1H2BF 0.000300020472922898 -HIST1H3F 0.042215361750485 -HIST1H3G 1.71005632806188e-05 -HIST1H3D 0.011195071454157 -HIST1H4K 0.429118935200097 -HMGN4 0.557082341510099 -HIST1H2AI 0.581587114173739 -PRSS16 2.23791834002529e-06 -HIST1H4I 0.446296012965993 -HIST1H2AG 0.000610464103704842 -HIST1H2BK 0.490754148427297 -HIST1H2BJ 0.47884211441258 -HIST1H2AH 6.2950794420684e-05 -HIST1H2AJ 0.19119768143705 -HIST1H2BM 0.00275346435077864 -ZNF184 0.133748635714874 -ABT1 0.0271055673799205 -HIST1H4J 0.423753830207411 -HIST1H2BL 0.00286755404850941 -HIST1H3H 0.02493915563981 -BTN1A1 1.14088369109076e-09 -ZNF391 9.25869403182407e-07 -ZKSCAN3 0.000122608322341288 -ZSCAN16 2.67303498489914e-06 -ZKSCAN4 6.74288454800845e-05 -OR2B2 6.86720334316105e-05 -ZSCAN9 4.10248860506101e-08 -HIST1H2AL 0.0624869158210738 -HIST1H4L 0.191234624133278 -HIST1H2BN 0.139774615254902 -ZSCAN31 3.7712697083703e-09 -NKAPL 0.000165621301014734 -HIST1H2BO 3.07277582735277e-05 -ZNF165 0.000563292029886091 -HIST1H2AK 0.0684285015781424 -PGBD1 1.46735073363618e-05 -HIST1H3J 0.695883936820569 -HIST1H2AM 0.000856482029037302 -ZKSCAN8 0.000231594506551783 -OR2B6 0.0407309275321611 -HIST1H3I 0.360879945054601 -HIST1H1B 0.509138756022723 -ZSCAN12 1.43991732878074e-05 -OR10C1 0.227592079399406 -OR2B3 0.0013369321318042 -OR12D2 0.601033125257784 -SCAND3 9.70724396864633e-09 -OR2J2 0.0107267189301636 -GPX6 3.13757952195529e-05 -OR12D3 1.34136303903671e-05 -GPX5 0.00888467745572368 -ZNF311 0.000129446471411909 -OR2H1 0.0449040613109769 -OR2W1 0.0865618905271982 -OR11A1 0.0434844025575059 -OR14J1 8.02406099709927e-08 -TRIM27 0.878751858118275 -OR2J1 0.0174945019459341 -OR5V1 0.00344261897900665 -ZSCAN23 0.00270295085017911 -OR2J3 0.0281435008681581 -HLA-E 0.347084032103792 -ZFP57 0.00181593681997415 -UBD 0.0798957514124674 -RPP21 0.0824539766931298 -GABBR1 0.999969901472702 -HLA-G 9.54870629366445e-08 -HLA-F 4.40041067524121e-05 -HLA-A 0.132779664827761 -RNF39 0.00666120713219206 -OR2H2 0.0899459247726437 -TRIM40 1.53055068540437e-07 -TRIM15 2.18350911167555e-11 -TRIM31 0.0163881344679348 -PPP1R11 0.783087010418086 -ZNRD1 0.144862729781844 -TRIM10 9.94954187768385e-06 -TRIM26 0.829653548058971 -MAS1L 0.000466205666114264 -TRIM39 0.999421097975261 -MOG 0.103680312661872 -C6orf136 0.87389420310306 -DHX16 2.0110821119233e-07 -MRPS18B 0.000565208886259378 -DDR1 0.0264778570642852 -GTF2H4 0.25803488725879 -PPP1R18 0.12120153280798 -PPP1R10 0.999999767757527 -ATAT1 0.0143739247782645 -MUC21 0.331419151101163 -FLOT1 0.0152734382576229 -VARS2 4.21949935405234e-14 -TUBB 0.875276521102353 -GNL1 0.999930615118599 -NRM 0.142577186791213 -SFTA2 0.594981142208541 -MDC1 0.00094184680344876 -IER3 0.671461598838892 -DPCR1 0.140380580992053 -ABCF1 2.7302422835602e-06 -PRR3 0.114320038533931 -LTB 1.00562999342202e-05 -HLA-C 9.94564281082044e-10 -CDSN 0.499451801068193 -DDX39B 0.997728044454765 -CCHCR1 6.50103692455086e-08 -ATP6V1G2 0.224789736223208 -LTA 0.743246562194033 -C6orf15 0.00142769734419249 -TCF19 0.000232743975557081 -TNF 0.272829190351182 -LST1 0.00253791495629015 -MICA 0.000378019716342188 -NFKBIL1 0.816647169800353 -PSORS1C2 0.104502852669113 -POU5F1 0.889691089140015 -MICB 0.000284376917984568 -MCCD1 0.00896309387231422 -PSORS1C1 0.00085535591737133 -HLA-B 0.00266463463685607 -APOM 0.00854307555982986 -BAG6 0.999987885791662 -CSNK2B-LY6G5B-1181 0.196071244498545 -CSNK2B 0.943856699084629 -DDAH2 0.842139471278318 -ABHD16A 0.988882578133094 -LY6G5B 0.000871193542460961 -LY6G6D 0.542857604337903 -LY6G6C 0.0016526950106923 -LY6G5C 0.614670423249105 -PRRC2A 0.999999999990663 -GPANK1 0.000931901014120056 -AIF1 0.0127986482867158 -C6orf47 0.16984783307713 -C6orf25 0.0040376920872826 -NCR3 0.00146130688438596 -MEGT1 2.30552003730605e-05 -LY6G6F 2.55909344216693e-06 -ZBTB12 0.807401018591612 -SAPCD1 2.31956261529551e-07 -SKIV2L 1.11011779473699e-15 -NEU1 1.93153899716433e-05 -MSH5 6.13879541730601e-08 -SLC44A4 8.27829933247523e-08 -HSPA1L 2.19040919542089e-06 -EHMT2 0.0644714712842996 -LSM2 0.00596281731563641 -DXO 4.98479742091705e-10 -VWA7 4.28880941939168e-07 -STK19 0.00461708135223375 -NELFE 0.756273167199129 -CLIC1 0.0124562134918973 -CFB 0.000978859412496618 -VARS 0.67979413526559 -C2 1.37888637170214e-06 -C6orf48 5.82446544381436e-05 -NOTCH4 1.19532150508521e-10 -AGPAT1 0.984453681304784 -HLA-DRB1 5.62352879494898e-05 -PBX2 0.889707316038439 -C6orf10 1.22806574585252e-13 -ATF6B 1.6770144203098e-06 -GPSM3 0.609591627820476 -PRRT1 0.407945729723328 -TNXB 0.774153751864359 -AGER 1.46448261051773e-10 -FKBPL 5.3549944756646e-05 -CYP21A2 0.672306731067129 -HLA-DRA 0.700164889675938 -BTNL2 2.02725572868094e-07 -RNF5 0.00299042376639745 -EGFL8 3.51576835152093e-06 -PPT2 0.772683334522566 -HLA-DRB5 0.0032272662883476 -BRD2 0.999530880243209 -HLA-DMB 0.00490510636506002 -HLA-DQB2 0.00935592869459469 -PSMB9 0.225647028212841 -TAP1 0.286650163167608 -HLA-DPB1 7.18465788950328e-09 -SLC39A7 0.0149907535503378 -HLA-DPA1 0.000185717032888532 -COL11A2 0.999999324603711 -RXRB 0.99759435069672 -TAP2 0.00171341819174486 -HSD17B8 0.744497984421353 -HLA-DOA 1.88487379125175e-05 -HLA-DQB1 0.353015151654053 -HLA-DOB 9.08751665004379e-05 -PSMB8 0.0120031719912635 -HLA-DMA 0.687977633420569 -HLA-DQA1 0.166625329932453 -RING1 0.915792421657898 -HLA-DQA2 0.00504406368032515 -IP6K3 0.0485338526527661 -WDR46 8.42034553335386e-06 -RPS18 0.962013320594563 -DAXX 0.842736879816879 -TAPBP 0.000393581688587975 -SYNGAP1 0.999998449747972 -ZBTB9 0.0121593630542635 -PFDN6 0.859422179892135 -RGL2 0.0747682997961984 -UQCC2 0.0595477327271092 -BAK1 0.00348654810029572 -B3GALT4 0.236708748288266 -CUTA 1.14218167340545e-05 -VPS52 0.0159632630188721 -KIFC1 0.0155780337232565 -ZBTB22 0.235099436717728 -ITPR3 4.97536705049387e-12 -PHF1 0.999558759279796 -SBP1 0.00238547209488957 -TCP11 4.00945484653237e-05 -GRM4 0.979350085369263 -HMGA1 0.724299774339856 -C6orf106 0.454029671085684 -SCUBE3 0.9999837065276 -PPARD 0.966868134632325 -SNRPC 0.727261777653869 -LEMD2 0.302373361272148 -ANKS1A 0.84685967793139 -PACSIN1 0.991339222233708 -DEF6 0.976824149100722 -ZNF76 5.07288621916122e-16 -SPDEF 0.711825442176907 -C6orf1 0.29871864309512 -RPS10 0.946462997504496 -NUDT3 0.876816622471426 -MLN 0.00165857384360036 -FANCE 0.00313889923167915 -UHRF1BP1 2.46541297366596e-07 -TAF11 0.875431936618392 -ARMC12 0.000270201697673098 -PXT1 1.3167645760551e-05 -BRPF3 0.993940981411932 -MAPK13 5.48349848830244e-07 -SRPK1 0.000394806789886588 -RPL10A 0.30237883059711 -MAPK14 0.997467188213903 -SRSF3 0.976175209668048 -PNPLA1 0.000465200350864785 -ETV7 2.00672826880885e-08 -LHFPL5 0.494778072886935 -SLC26A8 7.64803110765732e-08 -TULP1 0.80790432015979 -CLPSL1 0.00164846548972643 -CLPSL2 0.146625366873331 -KCTD20 0.399321757575798 -STK38 0.853295086026932 -C6orf222 1.39401452747336e-13 -FKBP5 0.498849476622916 -CLPS 0.0562747598072514 -GLP1R 0.0640780487665267 -PIM1 0.886575782773823 -FGD2 4.70751448593272e-05 -MTCH1 0.964878856015847 -ZFAND3 0.961977905050761 -DNAH8 2.09466493164173e-37 -MDGA1 0.995236956713737 -GLO1 0.000220688734065718 -TBC1D22B 0.0063706262671989 -CDKN1A 0.0272025507564846 -C6orf89 8.22352243978553e-05 -BTBD9 0.00573299396733052 -RNF8 0.995892884804807 -COX6A1P2 0.139600415963223 -PI16 4.4012998949913e-07 -CPNE5 0.0778897502698332 -CCDC167 0.00208987937449307 -PPIL1 0.013003975971324 -CMTR1 0.999294924067237 -TMEM217 0.00500602743445728 -TREML4 2.78304131594225e-05 -SAYSD1 0.000747903956143336 -KIF6 1.03952440427845e-16 -NFYA 0.0220592707694253 -TREM1 0.000343966174620477 -FOXP4 0.671770825297787 -TREML2 1.29204332519966e-07 -NCR2 0.000163783304597834 -KCNK5 0.884297675252843 -UNC5CL 1.666644191506e-07 -APOBEC2 0.132007272868405 -KCNK16 0.0113618650298823 -TREML1 1.00255175928297e-05 -TSPO2 4.28516292472018e-07 -DAAM2 0.998285962155217 -OARD1 0.12375137115757 -TREM2 2.35316946822257e-08 -MOCS1 0.000969834096250532 -LRFN2 0.117460637188488 -KCNK17 3.39348404854779e-06 -PGC 3.30129659251128e-06 -CCND3 0.946445162222962 -TFEB 0.968857337769685 -TRERF1 0.999595776775278 -PRICKLE4 7.00664679526374e-06 -USP49 0.943537458576996 -BYSL 0.0673214421779635 -TBCC 0.0110028256898399 -GUCA1A 0.00991832803266624 -UBR2 0.999999880132158 -PRPH2 0.388059586223376 -MDFI 0.144418737080253 -MED20 0.48894272078137 -TAF8 3.04223621180909e-09 -FRS3 0.808550861208179 -GUCA1B 0.00199506191376467 -MRPS10 0.0282121460745838 -GLTSCR1L 0.999918135203136 -DNPH1 0.000716569937593186 -PEX6 0.00284958751998099 -PPP2R5D 0.997520078948917 -MRPL2 0.00159372149990342 -RPL7L1 0.201503933112919 -PTK7 0.975879481016201 -SLC22A7 3.71516467731254e-06 -KLC4 0.236002384577825 -KLHDC3 0.993829271351028 -MEA1 0.0434012333734021 -SRF 0.970031287954396 -CNPY3 0.466081200956065 -TTBK1 0.9973069629351 -PTCRA 0.0113951526484819 -C6orf226 0.494949271877891 -CUL9 0.967475855018408 -CUL7 2.23525658801241e-11 -GNMT 0.667933555724909 -CRIP3 0.0339026389635781 -RRP36 9.22385848172131e-11 -MRPL14 0.0369989874032739 -MRPS18A 0.00112610816941113 -MAD2L1BP 0.0082444395179893 -ABCC10 8.30539108826425e-21 -SLC35B2 0.700038249852824 -ZNF318 0.0537829671346281 -SLC29A1 0.964281534686621 -LRRC73 0.635116132508035 -DLK2 0.685774157956481 -RSPH9 0.00490037811031499 -XPO5 0.999999368728011 -TJAP1 0.00105939310202612 -C6orf223 0.0204906742338502 -POLH 0.00359087143137192 -POLR1C 0.000291622651225996 -HSP90AB1 0.99529931563779 -GTPBP2 0.884778920255619 -YIPF3 0.812100973786078 -CAPN11 2.97448051307409e-10 -TMEM63B 0.999844992461849 -GPR116 0.990814985963621 -CYP39A1 2.01302072315531e-12 -MEP1A 5.76708569342659e-07 -AARS2 1.64858013716987e-07 -TDRD6 6.46494143305785e-23 -ENPP5 1.91660634387746e-05 -RUNX2 0.995958899294884 -PLA2G7 8.02276784444073e-11 -RCAN2 0.430936968293151 -CLIC5 0.00187685115916181 -NFKBIE 0.548429215223667 -TCTE1 3.26370848659523e-07 -SLC25A27 0.160724478287132 -SUPT3H 0.000109913332445794 -SPATS1 0.000191249661738644 -ENPP4 0.414683930724528 -CDC5L 0.999992549267724 -CRISP1 0.000219401762806872 -GPR115 3.9103549200985e-06 -DEFB114 0.162703129468739 -TNFRSF21 0.656653056375282 -DEFB110 0.0332221914618416 -CRISP3 0.000109838277984035 -CENPQ 6.26744705048062e-07 -PGK2 9.50692786238878e-06 -RHAG 0.340299251263077 -GPR110 4.78541618591994e-11 -GPR111 2.1438019263369e-11 -OPN5 0.948752683071951 -MUT 5.92436972896757e-18 -DEFB113 0.000538841057144388 -CD2AP 0.813221347122531 -PTCHD4 0.00276059838903919 -CRISP2 7.55320333504596e-10 -MCM3 6.37332148340467e-07 -TFAP2D 0.981586998492109 -IL17F 0.0302739252616752 -PAQR8 0.17786881683175 -GSTA1 0.0590105424594988 -ELOVL5 0.924260371630133 -GSTA2 4.24100248085288e-08 -IL17A 0.16720839132903 -GSTA3 0.0868631567505918 -GSTA4 0.0213022543085222 -EFHC1 5.05957542028851e-12 -TMEM14A 0.121253231019811 -TFAP2B 0.990904305042869 -DEFB112 4.67296856823663e-05 -ICK 0.10744982933628 -PKHD1 2.88608936958615e-23 -GSTA5 3.9842196790073e-09 -GCM1 0.988333939596922 -FBXO9 0.734879394524417 -TRAM2 0.99535786489498 -LRRC1 0.573184205198454 -HCRTR2 0.0636440358462457 -BEND6 0.135146272891265 -HMGCLL1 8.77269111699165e-07 -RAB23 0.038517374000133 -KLHL31 0.0190832639670692 -FAM83B 7.60280952486396e-08 -DST 0.99999999999999 -COL21A1 1.1540367820735e-20 -GCLC 0.815078354570402 -TINAG 4.10810051835617e-18 -MLIP 1.01588135455232e-11 -BMP5 0.000107433236892632 -KHDRBS2 0.142878302250928 -GFRAL 0.000114819883521722 -ZNF451 1.98298362859696e-06 -KIAA1586 1.77777131304971e-06 -BAG2 0.0883361376691997 -PRIM2 5.14707916843554e-08 -EYS 8.21411418968935e-09 -FAM135A 0.787125610333894 -KHDC1L 0.013352848445668 -LMBRD1 1.94347159526564e-06 -OGFRL1 0.000150358853454911 -B3GAT2 7.03605213348901e-07 -KCNQ5 0.99953508656607 -KHDC1 6.80134798473891e-05 -DPPA5 0.000949315393546459 -COL9A1 4.77422931673328e-15 -COL19A1 5.55032017757713e-17 -KHDC3L 0.24120460893701 -SMAP1 0.983689233136559 -PTP4A1 0.889900786451036 -RIMS1 0.0292114494347639 -C6orf57 0.0300229381181541 -FKBP1C 0.000605467062300138 -PHF3 0.999469419864182 -LGSN 2.5899855281394e-07 -BAI3 0.99999996623609 -MTO1 9.81851398890532e-05 -IMPG1 6.13186468480682e-13 -HTR1B 0.645559516982246 -HMGN3 0.175434355125753 -DDX43 6.82016832652361e-05 -MB21D1 2.61494381328063e-05 -IRAK1BP1 0.000864773844343313 -OOEP 0.230723598205906 -MYO6 0.0177883990936548 -SENP6 0.999876821596652 -COL12A1 0.999999611399328 -LCA5 0.00428217416197877 -FILIP1 1.85337719894375e-07 -SLC17A5 0.0221961749395672 -PHIP 0.999999947701654 -EEF1A1 0.984461027263021 -CD109 2.28792087896417e-32 -COX7A2 0.3755612546357 -TMEM30A 0.04068308491811 -IBTK 0.901146102319855 -RWDD2A 0.000931281554491641 -KIAA1009 6.36089024759487e-20 -MRAP2 0.00034873923097844 -CYB5R4 0.000343480484234464 -PGM3 0.0235635730698108 -PRSS35 1.33594366817905e-06 -SH3BGRL2 7.16872263567788e-06 -SNAP91 0.974350743810835 -TTK 0.00535776884387935 -BCKDHB 2.91008815830628e-06 -ME1 2.22311340829984e-10 -FAM46A 0.34745796945762 -DOPEY1 0.999995778425231 -RIPPLY2 0.078765747544666 -TPBG 0.123234260109032 -UBE3D 9.57947053072492e-08 -TBX18 0.997468364011956 -ELOVL4 0.74105115457534 -AKIRIN2 0.975340569110996 -CGA 0.251018987056367 -PNRC1 0.836159280405651 -SYNCRIP 0.999378591415277 -SLC35A1 0.208304140627799 -NT5E 2.33633611917161e-06 -CNR1 0.155072221772085 -ORC3 0.00030999720359409 -HTR1E 0.0237097657740907 -RNGTT 0.763456431133887 -SNX14 6.79995024969682e-10 -C6ORF165 3.10221622487386e-05 -SPACA1 0.382221740156508 -ZNF292 0.999976984136083 -RARS2 3.49435482374605e-06 -SMIM8 0.0358536168485527 -GJB7 1.49897888141327e-06 -MAP3K7 0.998336232242865 -KLHL32 0.509586628745803 -LYRM2 0.0596813347506901 -EPHA7 0.987759366731359 -FUT9 0.0813711620521245 -FHL5 1.6770876188147e-08 -UFL1 1.9081642881261e-12 -GABRR1 2.12253958201951e-07 -GABRR2 4.52031672010083e-07 -SRSF12 0.01623122038502 -GPR63 0.646359079516381 -MANEA 0.000414997365079232 -GJA10 4.55274700970182e-13 -PM20D2 0.00116674345055796 -MDN1 0.999999999489064 -ANKRD6 3.48769137996221e-07 -BACH2 0.874039851139597 -UBE2J1 0.857925444410675 -RRAGD 0.812902090860283 -NDUFAF4 0.382015184836328 -SIM1 0.99693618254279 -CCNC 0.990104533528106 -LIN28B 0.721962206839986 -ATG5 0.981561830973196 -FAXC 0.872413322160328 -GRIK2 0.994567954112697 -BVES 0.000308542708446569 -POPDC3 1.70813560977159e-05 -PNISR 0.999085487307753 -ASCC3 1.42788116112326e-10 -PRDM1 0.980264413149198 -PREP 0.991043730072313 -HACE1 0.00159566252447192 -USP45 8.69749163787703e-14 -MMS22L 0.671142491080048 -COQ3 7.05935714539158e-10 -FBXL4 0.0079087988593491 -MCHR2 3.50210575927378e-05 -C6orf203 0.00178692275457031 -ARMC2 2.20161046716889e-08 -PPIL6 6.30258336517342e-08 -NR2E1 0.990508625123308 -OSTM1 0.0604714184790487 -CEP57L1 4.26476293249987e-09 -CD164 0.401084248143714 -SNX3 0.466342861502279 -PDSS2 1.89564464414184e-05 -SMPD2 8.11572389971647e-11 -AIM1 7.45739464483608e-20 -RTN4IP1 3.75201094361177e-06 -SCML4 0.268213054620722 -SESN1 0.000638247819798128 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0.44521331275852 -RNF217 0.0299836634081045 -C6orf58 1.61255593750847e-10 -KIAA0408 1.95785656687142e-06 -NCOA7 0.960907672037716 -TRDN 1.81677623808329e-10 -ECHDC1 6.03175404565904e-05 -NKAIN2 0.00783238533852385 -MED23 0.150657691204943 -STX7 0.00426311559874846 -EPB41L2 0.993883457586741 -ENPP1 2.30987361236777e-05 -ENPP3 6.43746414984857e-17 -MOXD1 8.99118348991882e-11 -PTPRK 0.980388546226756 -CTGF 0.124048405573342 -ARHGAP18 2.45958437535249e-06 -L3MBTL3 0.999498723142149 -SAMD3 1.09707510090606e-06 -ARG1 0.000499882512051677 -OR2A4 0.684827959840006 -THEMIS 0.142516979842166 -LAMA2 1.1846527263111e-24 -TMEM200A 0.835246151685534 -AKAP7 0.00159877310631196 -TMEM244 0.03708753594163 -AHI1 3.25663341010612e-14 -VNN2 1.01889678992448e-08 -SGK1 0.986448162634836 -EYA4 0.126429148938264 -SLC18B1 3.94675803740147e-10 -TAAR5 3.45752187600458e-07 -VNN3 0.0347314452513382 -ALDH8A1 9.45631299959995e-06 -TCF21 0.80536994429277 -RPS12 0.827435141809626 -TAAR8 0.000303108489621688 -TAAR1 0.000283698038082418 -PDE7B 0.946452268895357 -MYB 0.88184751057148 -HBS1L 0.924522220570616 -SLC2A12 0.0194084110413465 -TAAR6 0.153131232007238 -TAAR2 3.41448199446952e-06 -VNN1 2.35465646726636e-07 -TBPL1 0.879617094046 -PERP 0.141632278773961 -IFNGR1 0.327969027338138 -OLIG3 0.672757859435387 -MTFR2 0.000151538368941259 -PEX7 6.86128307466037e-08 -IL22RA2 1.20924934270126e-09 -PBOV1 0.00757239690458909 -CCDC28A 1.49777690050185e-05 -KIAA1244 0.98742288863517 -SLC35D3 0.149614410820931 -MAP3K5 0.995107743453563 -REPS1 0.999363610065212 -HEBP2 0.000947405784931283 -MAP7 0.929880601613702 -TNFAIP3 0.999666684982313 -ECT2L 7.34277312291911e-32 -IL20RA 0.00757531716048163 -TXLNB 1.64577814159854e-16 -VTA1 0.0824061412273581 -NMBR 0.000742388919470671 -SF3B5 0.600475506656737 -HIVEP2 0.999999664252267 -ADAT2 2.09083702776258e-08 -HECA 0.347342389373824 -PLAGL1 0.881694431277305 -GPR126 0.283489107749214 -UTRN 2.96803315260187e-09 -STX11 0.0200260555260361 -LTV1 2.0508487464442e-05 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0.00017261233677896 -PLEKHG1 0.000178677408303547 -AKAP12 0.37250182178499 -VIP 0.00582894419478932 -IYD 0.0883091920429625 -FBXO5 0.982078346510874 -RAET1E 1.85957575867062e-05 -ULBP2 0.00110138772463706 -TFB1M 1.15656604217462e-05 -IPCEF1 0.399940590099527 -SCAF8 0.999999979124473 -NOX3 3.57964894206844e-09 -SNX9 0.578575161358935 -TIAM2 0.124829516016011 -TMEM242 0.000194207923288789 -ZDHHC14 0.98236655846095 -MTRF1L 4.39782481222077e-07 -RGS17 0.380684169627847 -OPRM1 4.20778097354752e-05 -SERAC1 0.0024009813989791 -ARID1B 0.999949930200412 -CLDN20 0.000765369094942534 -CNKSR3 0.211063418499667 -GTF2H5 0.0468099786233029 -SYNJ2 3.52295821798563e-05 -TMEM181 0.468986734137893 -TULP4 0.99993680345815 -MRPL18 0.000794102804498299 -IGF2R 0.999999196216303 -SOD2 0.237154646295316 -SLC22A2 1.4191712191388e-09 -RSPH3 0.00139623159251261 -SLC22A3 3.31638540911901e-05 -FNDC1 3.07460719768204e-07 -LPA 2.4422277924849e-32 -PNLDC1 2.5447781123909e-08 -TAGAP 0.927102798290041 -DYNLT1 0.0392109729198064 -SLC22A1 1.23977716739769e-13 -ACAT2 1.26453863126978e-05 -SYTL3 2.13951132456814e-17 -PLG 0.00243511733948206 -TCP1 0.989085751892209 -EZR 0.988110189680017 -WTAP 0.995576734722068 -MAS1 0.000870823408355688 -PARK2 0.0218088318211922 -PDE10A 0.998485350613982 -T 0.000208190165714723 -PACRG 0.000104676937493315 -GPR31 0.000351018338141658 -CCR6 0.0664814988844572 -TCP10L2 0.694467188174552 -MPC1 0.145968077163696 -FGFR1OP 0.710817709841688 -QKI 0.963163356453829 -C6orf118 1.45572025749264e-17 -SFT2D1 0.350193452291255 -MAP3K4 0.999991910638856 -AGPAT4 0.674499951839515 -RNASET2 0.00948040570721487 -RPS6KA2 0.0847008861629755 -PRR18 0.488137895604996 -ERMARD 5.17462949024395e-10 -THBS2 0.245000802643493 -DLL1 0.999053067436918 -TBP 0.490805122134187 -KIF25 3.75351002915501e-09 -WDR27 2.39749911767589e-15 -TCTE3 0.00321873255866745 -FRMD1 5.14902401948958e-13 -PDCD2 0.000192308695614694 -FAM120B 2.3406676741202e-08 -PHF10 0.0838841643103564 -SMOC2 0.0129697790449358 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0.699066032235909 -TTYH3 0.979598759303839 -SNX8 0.165170968578774 -SLC29A4 0.00114748805216547 -MMD2 0.00091686259327882 -AIMP2 0.00146308205811016 -CCZ1 0.99469468815396 -USP42 0.998681652752129 -WIPI2 0.093680612051952 -RNF216 0.409334345064788 -FBXL18 2.5658113917006e-07 -ACTB 0.935803217105583 -EIF2AK1 0.000121058308025956 -FSCN1 0.776273596220643 -RBAK 0.0096768994616337 -PAPOLB 0.0371791800354128 -RBAK-RBAKDN 0.724663171287708 -PMS2 1.13903542422692e-13 -OCM 5.57372955370736e-06 -RADIL 1.30554853556863e-12 -TNRC18 0.999973965663352 -COL28A1 1.89303475564036e-20 -ZNF12 0.551264006012047 -FAM220A 1.23121895874442e-05 -ICA1 0.00495036829251652 -CYTH3 0.356369422651745 -FLJ20306 0.548118202921881 -GRID2IP 0.314734427863365 -C1GALT1 0.679379972140309 -GLCCI1 0.24528207975459 -ZNF853 0.000958951242529297 -C7orf26 0.82656655995323 -RPA3 7.56338766676384e-05 -RAC1 0.572395052728126 -MIOS 0.00143566907100511 -ZDHHC4 5.32054090170074e-10 -DAGLB 1.65016137668239e-06 -KDELR2 0.268728640616792 -ETV1 0.996674203240852 -THSD7A 0.999280748692625 -AGMO 3.25792688425734e-07 -ARL4A 0.640299399643897 -TSPAN13 0.609851374390786 -NDUFA4 0.480021717091325 -MEOX2 0.6852347181888 -NXPH1 0.555861072202942 -TMEM106B 0.515078464231904 -PHF14 0.206539239599482 -ISPD 0.00243660167412645 -AGR2 0.335455070189878 -ANKMY2 0.00022375835823033 -SCIN 4.08229993266863e-16 -BZW2 0.995822418135325 -SOSTDC1 0.303977581230425 -DGKB 0.669214093853988 -TOMM7 0.0547352976629651 -IL6 0.289669116993916 -SNX13 0.985321607862615 -CDCA7L 0.120661404768047 -STEAP1B 4.60216723976545e-05 -ABCB5 1.16623512959537e-23 -SP4 0.95128804346323 -AGR3 3.84686825137146e-14 -TMEM196 1.50141300317772e-05 -FERD3L 0.258156359245349 -TWIST1 0.182033891254288 -TWISTNB 0.309424388132866 -HDAC9 0.998375125074442 -FAM126A 0.803307844592117 -AHR 0.999872136742516 -ITGB8 0.998351443978669 -MACC1 7.56011564443965e-17 -RAPGEF5 0.997815952976676 -NFE2L3 1.09962052794343e-07 -GPNMB 1.12477120855255e-12 -NPY 0.588186085546856 -MPP6 0.930676770761374 -STK31 0.233315306725925 -CYCS 0.583556979310405 -HNRNPA2B1 0.970043353092889 -TRA2A 0.212371727129574 -C7orf31 7.44109236489478e-08 -CCDC126 0.351142326713522 -CBX3 0.633200403003169 -FAM221A 5.09767784280586e-09 -NPVF 0.00264028304563325 -MALSU1 1.78046134626036e-08 -OSBPL3 0.00266192967168592 -NUPL2 3.67028875429224e-05 -KLHL7 0.000319112118508392 -IGF2BP3 0.999726189174336 -DFNA5 1.21683174137448e-05 -SNX10 0.00585750531238308 -RP1-170O19.20 0.0286938131551325 -HOXA5 0.79621299361995 -HOXA4 0.00942667003682843 -HOXA2 0.278337993967382 -HOXA3 0.931754220622883 -HOXA1 0.0849873631655924 -HOXA9 0.000100012594431347 -HOXA6 1.80043020270311e-05 -SKAP2 0.909797277702382 -JAZF1 0.958302381623798 -TAX1BP1 2.99233082871036e-06 -HIBADH 0.25072009941523 -EVX1 2.93029181691565e-05 -HOXA10 0.678435260569461 -HOXA7 0.00316907031376716 -HOXA11 0.863825169181447 -CREB5 0.989844564730837 -GHRHR 0.00267945937720418 -CRHR2 6.66041350022908e-07 -WIPF3 0.000296998615800264 -CPVL 4.06683849640159e-07 -ZNRF2 0.590835927693181 -CCDC129 2.61411786914665e-17 -CHN2 0.0255023240305153 -PRR15 0.446963256775024 -GARS 0.788927209872354 -SCRN1 0.065188552320723 -FAM188B 2.24554390700363e-15 -FKBP14 4.19320787675072e-05 -NEUROD6 0.681645767008427 -PLEKHA8 2.06117242932264e-06 -INMT 0.000120277973301167 -ADCYAP1R1 0.00133478497077452 -NOD1 5.05414452036266e-13 -AQP1 0.0499256381399427 -GGCT 0.000385990598175728 -C7orf41 0.306492233024659 -PDE1C 0.000270703875847391 -KIAA0895 0.00114571990792928 -DPY19L1 0.142871737069563 -BBS9 6.37524189346244e-10 -NT5C3A 0.0123721939228459 -RP9 0.174162977653973 -FKBP9 0.072366214136072 -HERPUD2 0.906200797865081 -PPP1R17 0.000392906114832172 -BMPER 0.00107085516215034 -ANLN 0.923521451884595 -EEPD1 0.00265719814434564 -KBTBD2 0.991275949151835 -AVL9 0.00032549454622102 -SEPT7 0.992377500380079 -NPSR1 8.1777016956916e-07 -LSM5 0.0182319329650146 -TBX20 0.337045818385032 -RALA 0.950372431421878 -C7orf10 2.03063092087898e-09 -GPR141 1.53229743185974e-05 -MPLKIP 0.00205835193328243 -POU6F2 0.00036907554163621 -SFRP4 4.45782556410063e-05 -NME8 2.02524932547695e-21 -CDK13 0.751250538151318 -YAE1D1 0.125672788400272 -INHBA 0.556279739729954 -PSMA2 0.937474829201216 -AOAH 6.14602362973613e-11 -FAM183B 0.00150866331106646 -VPS41 1.16349819146267e-08 -EPDR1 0.029388013814021 -ELMO1 0.993000631915938 -C7orf25 0.352368932691872 -AMPH 0.0322665655002833 -STARD3NL 0.00554582817086751 -GLI3 0.999994739435503 -STK17A 0.176185204823442 -YKT6 0.852902232625853 -AEBP1 0.000218798556316862 -URGCP-MRPS24 0.0115516877111986 -POLD2 0.0443243929840342 -PGAM2 0.000842261527216773 -POLM 2.42618818804445e-08 -HECW1 0.999999893537852 -BLVRA 0.0832220297693768 -DBNL 0.070981914478068 -NUDCD3 0.706731711814528 -URGCP 0.207220454111315 -GCK 0.204306172514215 -SPDYE1 0.206335952529226 -UBE2D4 0.00231860847257596 -MRPL32 0.00129078014499608 -MRPS24 0.0016576685245083 -MYL7 3.65494513796836e-06 -COA1 0.0384625323456856 -CAMK2B 0.468620194092365 -OGDH 0.993695121200126 -ZMIZ2 0.999620382312933 -TMED4 0.292927703052725 -H2AFV 0.412114349708015 -NPC1L1 1.37380138652805e-10 -ADCY1 0.999909620125574 -IGFBP3 0.362251902433295 -IGFBP1 0.00178327971594811 -PPIA 0.808049495342876 -TNS3 0.999389290859683 -MYO1G 7.64108904488102e-07 -TBRG4 0.780939582899283 -CCM2 0.483088350953085 -DDX56 3.51574131414912e-06 -PKD1L1 1.72329201787273e-23 -C7orf65 2.78279603971715e-06 -RAMP3 0.00952875139018002 -NACAD 0.365728808142491 -PURB 0.605935032790202 -ZPBP 0.159636078544989 -SUN3 3.79821816082152e-05 -HUS1 0.000609572433043018 -VSTM2A 0.107352765766498 -UPP1 9.00844799997619e-05 -COBL 0.982698636920497 -DDC 4.60661229193956e-05 -SEC61G 0.611529456532535 -IKZF1 0.985751324145976 -LANCL2 0.786760146345929 -C7orf69 0.051049199904848 -GRB10 0.367423738728048 -EGFR 0.998664530178053 -POM121L12 8.97051067778844e-05 -AC004899.1 9.64120892106423e-05 -ABCA13 3.30732765255053e-78 -FIGNL1 0.000108679232933473 -C7orf57 4.29144419573902e-05 -VWC2 0.795160869537721 -ZNF107 7.59375740639872e-17 -VOPP1 0.12531564122422 -PSPH 0.709723367299492 -SEPT14 4.96607463060426e-05 -ZNF479 0.00810131717246567 -GBAS 4.14826721847044e-05 -ZNF727 1.56297034947385e-07 -ZNF736 0.143727833114872 -ZNF679 1.4326770609757e-09 -CHCHD2 0.000221319937862802 -MRPS17 0.74281378474708 -CCT6A 0.998661755000443 -PHKG1 3.5805417364897e-10 -ZNF713 0.00111519799587951 -SUMF2 5.52632393168249e-05 -ZNF680 4.59084206576754e-06 -ZNF716 2.56317973452826e-08 -GUSB 4.07005874224264e-05 -ERV3-1 4.31444689510584e-07 -RABGEF1 0.496529665997915 -CRCP 0.00139892682926566 -WBSCR17 0.0956174277642264 -TYW1 0.000457248889921904 -ZNF273 8.54685134114473e-06 -ZNF138 2.22312670470713e-07 -AUTS2 0.996187482008472 -KCTD7 0.496529665997915 -ASL 3.8494991468686e-08 -VKORC1L1 0.851484218854318 -SBDS 0.119263624331666 -TYW1B 8.1161283885492e-09 -ZNF92 9.99259330998176e-08 -CALN1 0.153650290078419 -TPST1 0.0114811021514916 -ZNF117 0.00021360138840966 -TMEM248 0.422731519664078 -DNAJC30 0.00479827795416004 -WBSCR28 1.58800503099146e-06 -WBSCR27 0.0679116625114122 -TRIM74 0.780333820359187 -BCL7B 0.706637383924404 -STX1A 0.910475757164848 -ELN 1.51996287413625e-05 -WBSCR22 0.52115193984232 -CLDN4 0.00013715830896755 -FKBP6 0.13060063873413 -TBL2 0.00437650656905421 -ABHD11 9.03291221619057e-06 -CLDN3 0.678537320145956 -VPS37D 0.656347210550458 -BAZ1B 0.999999562861573 -TRIM50 2.72561665019464e-06 -NSUN5 1.45415268581091e-06 -MLXIPL 0.676823094036297 -WBSCR16 0.000647047934647949 -LIMK1 0.990896287164463 -RFC2 4.04212746398499e-05 -NCF1 0.92335956129349 -HIP1 0.999681016475132 -LAT2 0.000691063098880473 -EIF4H 0.922544880243499 -CCL26 0.019786154155303 -GTF2IRD1 0.996434356913921 -GTF2I 0.999348689931056 -CCL24 0.0171892202994171 -RHBDD2 0.646226806703523 -CLIP2 0.999881647285659 -POR 4.33906087150102e-05 -SRCRB4D 9.86180795293454e-05 -STYXL1 0.00974654300814003 -CD36 8.31103233660849e-46 -TMEM60 0.661431575510107 -CCDC146 3.02024489245997e-18 -PTPN12 0.999459858785815 -HSPB1 6.92483241362485e-06 -YWHAG 0.937613568815639 -MAGI2 0.883174386756098 -SRRM3 0.911827252904099 -FGL2 0.0949976759625154 -RSBN1L 0.500030091124699 -UPK3B 0.000192328231865901 -ZP3 0.00159681546702936 -MDH2 0.177605135901673 -GNAI1 0.917528243665787 -GSAP 3.59525944818388e-16 -POMZP3 0.879121225424826 -DTX2 0.106757915614529 -PHTF2 0.0249464272569149 -DBF4 0.998167681555921 -ABCB4 0.000203043316816073 -ABCB1 0.734473812399813 -SEMA3A 0.988432782312704 -GRM3 0.984710456532565 -TMEM243 1.28559617872968e-05 -DMTF1 0.956216302595223 -SLC25A40 2.14670620627733e-07 -HGF 0.994701028645709 -CROT 6.7490162375597e-21 -SEMA3C 0.296856253558956 -CACNA2D1 0.999995804404225 -PCLO 0.999999999988929 -GNAT3 0.000297548170729583 -SEMA3D 3.53080230466104e-05 -KIAA1324L 0.000166955192879022 -RUNDC3B 0.00149189416804701 -SEMA3E 0.0304478723822677 -ADAM22 0.999388899396346 -CLDN12 0.10092139715214 -KRIT1 0.0942382450327803 -STEAP4 1.49862010031802e-05 -ERVW-1 0.0135671717993117 -C7orf62 0.0235072221293244 -GTPBP10 0.13073148451219 -MTERF 9.3827857727949e-07 -FZD1 0.344486647877948 -STEAP2 0.00244974706931913 -ZNF804B 4.77795175322779e-14 -CYP51A1 9.85961120147983e-06 -STEAP1 0.434511093853516 -PEX1 3.96976240276807e-05 -C7orf63 0.000134084128006003 -SRI 9.97957046166647e-05 -GATAD1 0.507483499064787 -AKAP9 2.29354530903585e-05 -ANKIB1 0.999885674650132 -CDK14 0.476260128391186 -SAMD9L 3.79851707301836e-10 -PON2 0.0014042483858281 -CDK6 0.923677276455166 -PPP1R9A 0.0513404120249266 -SAMD9 1.28543048483051e-23 -HEPACAM2 8.70715988746485e-09 -BET1 0.00201119979865631 -TFPI2 0.237365841602754 -SGCE 0.00138632178574484 -CALCR 3.37646968831731e-05 -CASD1 0.0367943378808448 -GNG11 0.163792461884714 -CCDC132 0.991409342401086 -RBM48 5.12365921814138e-05 -PON3 0.00253678311281302 -COL1A2 0.99975494444276 -PEG10 0.894178858164044 -PON1 0.00220884417330799 -GNGT1 0.276892736896177 -FAM133B 0.000297398530792941 -NPTX2 0.0975684543323326 -DLX6 0.842830433475103 -LMTK2 0.994402282503334 -SHFM1 0.418592332178749 -ASB4 0.0110197125961939 -DYNC1I1 0.0116377037964894 -DLX5 0.675979516490967 -SLC25A13 1.9404630788689e-15 -TECPR1 2.43068227306975e-07 -BRI3 0.0152584135023695 -BAIAP2L1 0.042773725631072 -TAC1 0.877314614642078 -OCM2 0.0800687372958595 -ASNS 0.00166592807757199 -TMEM130 1.28738785007366e-08 -BHLHA15 0.14284139616861 -PDK4 4.55196606471685e-06 -ACN9 0.014583040343596 -ATP5J2 0.348503040158147 -ATP5J2-PTCD1 1.77777327849927e-09 -ARPC1B 0.156070499348014 -FAM200A 6.00941061236888e-05 -CYP3A4 2.81509485996385e-07 -ARPC1A 0.734759682759801 -CYP3A7 2.92836029852247e-07 -ZNF789 7.06159747447558e-08 -BUD31 0.417010233438905 -ZNF655 0.0378918199572815 -PTCD1 1.77777327849927e-09 -CPSF4 0.629613784158072 -PDAP1 0.00558937831758173 -ZNF394 0.0433348237892985 -ZSCAN25 0.214589397019398 -TRRAP 1 -SMURF1 0.996803391218968 -ZKSCAN5 0.000618302540533773 -CYP3A5 5.21037691769514e-11 -TRIM4 1.68258188143666e-06 -ZKSCAN1 0.607275236573615 -CYP3A43 1.47487370812895e-10 -ZNF3 0.0089610568357088 -MCM7 1.4578327477307e-13 -GAL3ST4 3.81535057360793e-10 -STAG3 1.10348940584416e-06 -LAMTOR4 0.0256870248906026 -CNPY4 3.6762305295632e-09 -MBLAC1 0.313958463301017 -ZSCAN21 1.70973909902822e-11 -AZGP1 0.0175975830278723 -COPS6 0.84586120251302 -GATS 0.000965025102116515 -GPC2 0.307395086157098 -TAF6 0.00067416521660161 -C7orf43 0.300413006639945 -GJC3 0.00578882239787705 -OR2AE1 0.00537432026972538 -AP4M1 2.36166196366206e-11 -TSC22D4 0.894817346966523 -PCOLCE 0.500664877958131 -PPP1R35 0.00198348749453857 -GIGYF1 0.978704811680111 -MEPCE 0.996809251755068 -SPDYE3 0.825434138244106 -TFR2 0.000139030759104317 -NYAP1 0.990932129553248 -GNB2 0.989239434673184 -MOSPD3 0.00160694416950915 -PILRB 3.36639654254602e-06 -PVRIG 0.0010018919897152 -FBXO24 0.141279967523548 -ACTL6B 0.987130694865973 -AGFG2 0.00476446377841632 -ZCWPW1 1.15224577774625e-12 -PILRA 2.14141882603506e-08 -C7orf61 0.0120812493963009 -LRCH4 0.00017644288346698 -ZAN 1.56059061227021e-43 -SERPINE1 0.219519976967254 -CLDN15 0.889708635311524 -ZNHIT1 0.000428046419828023 -AP1S1 0.52022703354864 -NAT16 5.90939217834721e-05 -UFSP1 0.00559926862470787 -EPO 0.116862381941263 -TRIM56 0.0801579223006073 -MOGAT3 2.40335585035369e-10 -TRIP6 0.659398351134913 -SRRT 0.982967889936454 -EPHB4 0.989869332436591 -VGF 0.825896021447167 -PLOD3 3.88014355176489e-08 -SLC12A9 2.37211122104682e-06 -POP7 0.285660408621197 -ACHE 0.996674942122373 -FIS1 0.0401785771611955 -ORAI2 0.336548283911044 -COL26A1 0.000191086087413664 -RABL5 0.525713723655738 -PRKRIP1 0.000394800445184658 -MYL10 0.00804655016342347 -RASA4B 0.57564632650937 -ALKBH4 0.496783561003534 -POLR2J2 0.0923409063648301 -POLR2J 0.444173138750063 -LRRC17 6.63875292520614e-08 -CUX1 0.999988877535193 -SH2B2 0.0113599414609977 -RASA4 0.661336761566351 -FBXL13 1.66151922936947e-11 -LRWD1 2.01862470800891e-07 -ATXN7L1 0.11109157508575 -CDHR3 6.98636378515767e-13 -PUS7 2.16505288475568e-05 -PIK3CG 0.56396387141262 -CCDC71L 0.482182658122372 -RINT1 1.92725153213016e-06 -NAPEPLD 0.0627214993961428 -SLC26A5 0.00137555507026871 -NAMPT 0.982566484474744 -SRPK2 0.997504054449169 -PSMC2 0.999210832748991 -PMPCB 5.37977878966889e-06 -SYPL1 0.289132309522734 -RELN 0.999999999999998 -EFCAB10 0.100686560719915 -LHFPL3 0.795069316295047 -DNAJC2 0.984694417551266 -ARMC10 0.0312022174247536 -ORC5 2.288348167214e-05 -KMT2E 0.999999994702687 -C7orf66 0.00581436531098041 -LRRN3 0.686452349711702 -SLC26A4 6.36692519367205e-13 -LAMB4 3.21022487204354e-30 -THAP5 0.00279203530856965 -DLD 0.371053212777847 -SLC26A3 3.07620637453319e-10 -HBP1 0.770302411913946 -PRKAR2B 0.995321215882976 -GPR22 0.427181284606709 -CBLL1 0.997784847703943 -COG5 1.13576699864644e-11 -NRCAM 0.456484598308671 -IMMP2L 0.0407609178597598 -BCAP29 0.220058296267505 -DOCK4 0.998535732717338 -DUS4L 0.000141354055808242 -DNAJB9 0.224582946037773 -LAMB1 1.79440028222301e-06 -PNPLA8 0.00813185680534786 -WNT2 0.611106305088224 -ASZ1 1.71628994930091e-06 -IFRD1 0.105462456846984 -TES 4.84137383314076e-11 -TFEC 4.73106154908356e-05 -LSMEM1 0.00519486074970192 -C7orf60 0.99081083987417 -CAV1 0.0187079719750825 -MET 0.996412863765497 -TMEM168 0.0134130851252731 -CAPZA2 0.986605820644033 -FOXP2 0.996178831092855 -ZNF277 4.86865721154542e-14 -GPR85 0.810447100376797 -CAV2 0.00411638498497318 -ST7 0.998051871776655 -PPP1R3A 6.58740989250831e-07 -TAS2R16 0.0149965302399621 -ING3 0.9936029551269 -SLC13A1 1.83879119780268e-09 -PTPRZ1 0.994707963074545 -CTTNBP2 2.59915879681031e-06 -CPED1 8.34882400764031e-17 -TSPAN12 0.554920625997523 -NAA38 0.00827246331155774 -FEZF1 0.298172189886215 -IQUB 3.23577428041204e-13 -RNF148 0.000117583776346138 -CFTR 2.96390764420065e-36 -FAM3C 0.00108107460535983 -RNF133 0.015150794090117 -KCND2 0.980460832264043 -NDUFA5 0.173963053327748 -CADPS2 0.997778954042416 -WNT16 0.000185158701253108 -ANKRD7 0.00752456912905973 -AASS 1.35531507533066e-06 -RBM28 2.04684238620984e-09 -IMPDH1 0.00581185872999049 -ARF5 0.234001126600504 -WASL 0.961960486819179 -LRRC4 0.877360671606607 -ASB15 6.00806210432932e-08 -LMOD2 0.00499630318196295 -SPAM1 1.24369500877438e-06 -GPR37 0.799390711133167 -ZNF800 0.997032620126522 -FSCN3 7.76329851727915e-12 -POT1 0.522727216703268 -LEP 0.318971026075485 -GCC1 6.6895203134617e-08 -SND1 0.999917088790426 -PAX4 0.00337035582414097 -HYAL4 2.05182329925812e-15 -GRM8 0.0040386229885192 -FAM71F1 8.94982212165727e-06 -IRF5 0.288476015651223 -STRIP2 7.35176598741971e-10 -METTL2B 0.0827090983733214 -OPN1SW 0.369090989256908 -TNPO3 0.00138920147813071 -TSPAN33 0.000103178201876671 -FLNC 0.999503524836351 -KLHDC10 0.996683789589299 -UBE2H 0.970971739459398 -CALU 0.447140101291407 -CCDC136 4.88758232322395e-08 -FAM71F2 0.0624738918069958 -AHCYL2 0.949258836025037 -SMO 0.0637118150614874 -NRF1 0.996970242690309 -ATP6V1F 0.563002529826286 -HILPDA 0.422104597498185 -ZC3HC1 0.000510516198199949 -TSGA13 6.10474450186949e-09 -SSMEM1 6.42506346890127e-13 -COPG2 0.0560373568810472 -MEST 0.997526693420813 -CPA4 3.54914778603255e-07 -CPA2 1.7428258238813e-08 -CEP41 0.000125629303655449 -TMEM209 0.00520456472367071 -KLF14 0.21811382303303 -CPA1 1.10123631470328e-05 -MKLN1 0.999577504819181 -SLC35B4 4.5384262452846e-06 -PODXL 0.251078485785218 -CHCHD3 0.0404016311674061 -AKR1B1 1.07346253038348e-05 -EXOC4 0.000726958108385659 -CPA5 0.0474887384414102 -PLXNA4 0.9999997021004 -LRGUK 1.91691232979875e-08 -STRA8 0.00268491395995002 -PTN 0.289147235393633 -C7orf49 0.335421676073075 -TMEM140 0.0397282430652476 -CALD1 0.99909770368326 -SLC13A4 0.915550850591339 -DGKI 0.738016171796638 -CHRM2 0.00587059361264825 -MTPN 0.754654166903489 -FAM180A 0.337078259629403 -WDR91 0.00140853962093613 -CNOT4 0.996013724617981 -AKR1B10 1.2180120737993e-05 -BPGM 0.126322243893593 -CREB3L2 0.609225183555282 -AKR1B15 4.52992010086282e-15 -NUP205 0.999998807559353 -TRIM24 0.999995048034361 -C7orf55 0.0170096837393943 -TTC26 0.00767000315281739 -TBXAS1 1.37136184087511e-08 -JHDM1D 0.99869438014555 -TMEM213 0.0452604681604892 -PARP12 7.92982223351822e-06 -ATP6V0A4 1.94342756038366e-12 -ZC3HAV1L 0.0417616097396591 -C7orf55-LUC7L2 0.995965817862567 -HIPK2 0.998346420156677 -LUC7L2 0.590287985521778 -KLRG2 4.20606730807966e-07 -KIAA1549 0.998645789892966 -SLC37A3 7.1633846502858e-08 -ZC3HAV1 0.0218726180746054 -UBN2 0.998642622987556 -AKR1D1 5.69259631264517e-08 -SVOPL 0.00113327221416435 -CLEC2L 0.0175943800770233 -PRSS37 0.001727084840966 -ADCK2 0.000169237561936908 -TAS2R5 0.000103902616890766 -WEE2 0.000967997099215928 -DENND2A 0.972231280413339 -TAS2R38 0.065390402368431 -KIAA1147 0.00204302025834016 -AGK 2.4706842233331e-06 -MRPS33 0.00339571782411825 -OR9A4 0.000344414708783223 -BRAF 0.999978196041997 -SSBP1 0.058441518078084 -RAB19 4.08401148578637e-05 -MKRN1 0.97942365116225 -TAS2R4 0.0497384495024723 -MGAM 1.5473423744435e-23 -NDUFB2 0.0118150668313523 -TAS2R3 0.000144123847766213 -CLEC5A 0.238602268127914 -GSTK1 1.10372350730423e-09 -TRPV6 0.00141348404170926 -ZYX 7.73888873879817e-06 -FAM131B 0.921928277751244 -RP11-1220K2.2 0.0293800126236847 -PRSS58 6.15774870353692e-05 -TAS2R39 5.30383482902454e-08 -C7orf34 0.000149478331950413 -TRPV5 4.66125605838153e-10 -OR9A2 8.86431291599995e-05 -TAS2R40 0.00249983201307608 -OR6V1 0.0764745296511436 -KEL 2.00929288413252e-16 -CASP2 0.4231010544127 -TMEM139 0.0187541363348994 -PIP 0.0055055964537849 -CLCN1 6.82240250810421e-13 -PRSS1 0.00122029540045484 -EPHB6 0.253348704299398 -OR2A2 0.391377425515877 -ARHGEF35 0.12761661654485 -CTAGE6 0.366836244776785 -CTAGE15 0.784298473587336 -OR2A25 0.34776329142618 -TAS2R60 6.30040071512039e-06 -OR2A42 0.595675111848453 -TAS2R41 4.93429098643450e-09 -OR2A14 0.00212703548326032 -OR2F2 0.000573456091648581 -OR2F1 0.00428737773717987 -OR2A12 0.000159693166175513 -OR6B1 3.06652361670517e-05 -EPHA1 5.30365074340992e-11 -OR2A5 2.24250803002605e-05 -FAM115A 0.862004719189463 -ZNF777 0.997614409900424 -CNTNAP2 3.82882607342169e-05 -ZNF783 0.000963929173297341 -OR2A1 0.646778691858269 -KRBA1 1.47475623545829e-12 -ZNF425 3.18872671120405e-14 -ZNF467 1.71294598036323e-07 -ZNF862 3.68873263295519e-09 -PDIA4 0.014774296571888 -ZNF212 1.88610484725312e-06 -EZH2 0.999990079045986 -ZNF282 0.277662873290001 -ZNF786 1.40003789521225e-08 -ZNF746 0.0517385668171128 -ZNF398 0.959343721509368 -CUL1 0.999963289879359 -NOBOX 3.74460520566748e-05 -C7orf33 0.000634926247300206 -TPK1 0.0282545792431748 -GIMAP4 7.68887548397492e-05 -GIMAP8 6.85022595051609e-06 -GIMAP7 0.00184489304608896 -NOS3 2.21161070571318e-05 -REPIN1 0.961996440962356 -TMEM176B 2.99736600245482e-09 -LRRC61 0.00519555071411505 -RARRES2 0.00295445312501597 -ZBED6CL 0.00292226219818059 -AOC1 1.2402397245546e-08 -TMEM176A 0.399810437494734 -ACTR3C 0.00123151135996935 -GIMAP5 0.189192166314945 -ATP6V0E2 2.0563161489236e-05 -GIMAP2 0.00122833357888369 -GIMAP6 0.0973436196255574 -KCNH2 0.996051301626768 -GIMAP1 0.839321399910499 -ZNF775 0.0122292592081411 -ATG9B 1.85392629019537e-11 -TMUB1 0.314893201445842 -CDK5 0.94751618934918 -CRYGN 4.64269756915624e-05 -ASIC3 7.95974781199542e-07 -ABCF2 0.995417497143895 -SLC4A2 0.999960115734587 -SMARCD3 0.23191843214181 -AGAP3 0.991380425409819 -RHEB 0.954420413456341 -PRKAG2 0.977557428638321 -GALNTL5 6.05278672454337e-13 -GBX1 0.269607760761063 -ABCB8 4.59594908795322e-06 -ASB10 0.000421836172303841 -KMT2C 0.999999999999997 -WDR86 3.30809403776567e-11 -GALNT11 0.00404741904705645 -FASTK 0.0305313518323476 -NUB1 1.14912569365706e-05 -CHPF2 7.24132491401232e-17 -ACTR3B 0.997547180064581 -DPP6 0.96769110706309 -LMBR1 0.000687935571767197 -EN2 0.433107378953652 -RBM33 0.999967324739204 -PAXIP1-AS2 0.0916808795062666 -INSIG1 0.124543666409511 -HTR5A 0.00578863422656513 -PAXIP1 0.999932438035634 -SHH 0.912961328200915 -XRCC2 4.23850679023585e-06 -HTR5A-AS1 0.632521887487388 -RNF32 1.59862356818775e-08 -CNPY1 0.00874565540084683 -WDR60 2.00913621845281e-07 -VIPR2 9.34378712597189e-07 -NOM1 0.000163382709301448 -ESYT2 0.00844095092621287 -NCAPG2 0.975711232780226 -DNAJB6 0.963595740652646 -PTPRN2 0.0165571526676371 -UBE3C 0.999999273217422 -DEFA6 0.00438946005151902 -ZNF596 2.89554865880379e-14 -ANGPT2 0.454891016173085 -DEFA4 0.271968353462833 -ARHGEF10 1.10804741351534e-13 -ERICH1 1.38646429216599e-10 -MYOM2 1.48718449693549e-55 -DEFB1 5.06986674339156e-05 -AGPAT5 0.00579495332667733 -KBTBD11 0.273543144822399 -FBXO25 0.310315222130944 -DLGAP2 0.950397325917595 -CLN8 0.000747073250102511 -MCPH1 5.16507030687178e-18 -TDRP 0.00132192801257303 -DEFB106A 0.409307651822525 -DEFA3 0.489152996997351 -DEFB104A 0.519473453237245 -ZNF705G 4.24856211732445e-09 -SPAG11B 0.0472376897206403 -DEFA5 0.000100681038440857 -DEFB105A 0.436248234904372 -SPAG11A 0.0390121663586044 -DEFB4A 0.399812614148335 -CLDN23 2.46842024128337e-05 -SGK223 5.12369052262778e-20 -ZNF705B 0.652541803539784 -MSRA 1.69976100303061e-06 -C8orf74 1.01040579381024e-11 -MFHAS1 2.22820045783843e-05 -ERI1 0.000454685197816091 -PPP1R3B 0.0229191412335762 -PRSS55 1.2335690846368e-08 -XKR6 0.956776701241562 -SOX7 0.131241610927833 -C8orf12 0.311268910075586 -TNKS 0.777115954184058 -PINX1 4.9427916851122e-09 -MTMR9 0.210866148969841 -SLC35G5 0.0274846347511103 -DLC1 0.992807272978016 -FAM167A 0.000192997889999534 -USP17L2 0.0138587263197935 -GATA4 0.802155487205778 -DEFB135 1.31655071986469e-06 -FAM86B1 0.744460341331624 -NEIL2 2.11099583099423e-09 -DEFB136 0.0340000990200746 -LONRF1 0.919751764265427 -BLK 2.86165843035065e-07 -FAM86B2 0.674121349080742 -DEFB134 0.0322373411768572 -MTUS1 1.1438280194915e-05 -VPS37A 0.534958339986742 -MTMR7 1.63743798338027e-09 -PSD3 0.851705649436322 -MICU3 3.12316752281864e-06 -FGL1 1.873536127279e-16 -SGCZ 0.00198581635801512 -CNOT7 0.986495484302418 -PDGFRL 4.16904903414803e-10 -NAT1 2.8541046904519e-10 -SH2D4A 1.53114480649588e-18 -NAT2 0.0226078662097717 -ASAH1 5.35814510968979e-11 -SLC7A2 1.1726426517571e-08 -ZDHHC2 0.00703300683867723 -FGF20 0.702854984376326 -MSR1 8.20826841073278e-16 -TUSC3 0.00189876427347781 -HR 2.12734947334705e-05 -FAM160B2 2.05240114095338e-05 -DMTN 0.961762589977884 -GFRA2 0.337127994516478 -SFTPC 0.0684488020229368 -BMP1 0.868760693373601 -LZTS1 0.525971472516105 -LPL 3.33727737763241e-06 -LGI3 1.94564245688285e-05 -DOK2 2.33626639170304e-06 -SLC18A1 1.8888318573672e-14 -FGF17 0.865331559549294 -CSGALNACT1 6.87751081149391e-05 -REEP4 0.175027611415095 -ATP6V1B2 0.991448562707497 -NUDT18 0.000135276357888308 -XPO7 0.999999311353521 -INTS10 0.984216594645776 -NPM2 0.000671457222251747 -PHYHIP 0.873268767669363 -PEBP4 0.0388985351374596 -SORBS3 2.31106262231037e-06 -ENTPD4 2.06793054504749e-11 -TNFRSF10D 3.28274094560628e-05 -POLR3D 5.65731890104614e-11 -TNFRSF10C 1.31871168945746e-07 -CHMP7 0.980739996928141 -RHOBTB2 0.508425067947333 -CCAR2 0.960454889427648 -BIN3 5.99066271257055e-06 -LOXL2 2.99731375478488e-07 -PDLIM2 0.0497493108362985 -SLC39A14 0.314629295810412 -TNFRSF10B 9.803529644727e-07 -TNFRSF10A 3.93409884735762e-13 -PPP3CC 0.0166246432473754 -EGR3 0.81109794446274 -PIWIL2 0.0024831521594482 -C8orf58 7.25833522609638e-07 -DPYSL2 0.995558288769102 -SLC25A37 0.512222994662905 -CDCA2 1.61084700624997e-05 -STMN4 0.146519525068475 -DOCK5 0.00134268610814527 -EBF2 0.971965790083313 -ADAMDEC1 1.76177869055281e-09 -NEFM 0.0359563283297322 -BNIP3L 0.330817931436664 -NKX3-1 0.000884340872180055 -PNMA2 0.101076994690922 -NKX2-6 0.00352254257656912 -ADRA1A 4.17186626185209e-07 -STC1 0.473499049992616 -ADAM7 1.73705605343028e-12 -KCTD9 0.0733968308677995 -PPP2R2A 0.959642692100134 -ADAM28 1.96799528021972e-17 -GNRH1 0.0986916060732056 -ELP3 3.92611121629076e-07 -SCARA3 1.62407014825429e-07 -TRIM35 0.000940307552509518 -FBXO16 6.61703415087813e-07 -PNOC 0.151495123138375 -CLU 0.453463613311341 -EXTL3 0.0612804860054933 -NUGGC 1.95612770357102e-07 -SCARA5 0.0669917769697247 -HMBOX1 0.997096381434551 -ESCO2 0.178963923075095 -KIF13B 0.000199447010513076 -CHRNA2 0.00176647920423662 -CCDC25 0.051834010875526 -INTS9 2.00066301787045e-06 -EPHX2 4.92248524715445e-13 -PBK 4.09216216235921e-05 -FZD3 0.275435382319683 -PTK2B 0.984520870569303 -ZNF395 0.819057406199046 -FUT10 3.07918840008664e-07 -NRG1 0.947798761974756 -RNF122 0.0763862528356865 -TMEM66 0.00970133769736859 -TEX15 3.89144760802236e-17 -DUSP4 0.53906924159124 -GTF2E2 0.00866855235922082 -GSR 0.012481213675682 -RBPMS 0.783171944383471 -WRN 1.96078222210392e-16 -PPP2CB 0.622505955129438 -DCTN6 0.0262383991081917 -TTI2 0.00188633676443484 -UNC5D 0.849201861283474 -MAK16 0.993980456078529 -LEPROTL1 0.622320079235797 -PURG 0.934741136588781 -DUSP26 0.003914765174449 -GOT1L1 2.11851720642321e-10 -GPR124 0.000300880854492373 -PROSC 0.297119448410396 -LSM1 0.931276896697764 -ASH2L 0.995792115553242 -RAB11FIP1 2.10564412942988e-05 -LETM2 1.34235674967667e-10 -DDHD2 3.09639823750121e-08 -KCNU1 3.90823831937045e-12 -WHSC1L1 0.999999688469196 -PPAPDC1B 3.06881649960598e-07 -EIF4EBP1 0.184082876876197 -ADRB3 0.323569934345889 -BRF2 1.88281642938786e-09 -BAG4 0.0237409026699778 -STAR 3.07154052744717e-07 -ERLIN2 0.111582004871944 -GINS4 0.0504728646441056 -FGFR1 0.988744284614171 -ZMAT4 0.0193268627627965 -NKX6-3 0.190054225881154 -HTRA4 2.53128845476791e-07 -ADAM9 0.828249261024913 -SFRP1 0.465845741756302 -IDO2 9.40310162872685e-06 -AGPAT6 0.446180354943142 -ADAM32 1.1677289848388e-08 -C8orf4 0.0652714996147049 -ADAM2 7.2128414191772e-14 -IDO1 1.41760011324181e-05 -TM2D2 0.071028871563027 -GOLGA7 0.691723360705822 -PLEKHA2 0.363909173512548 -ADAM18 1.53440056708128e-19 -C8orf86 6.34747718357808e-05 -TACC1 0.0151208742819385 -ANK1 0.999999999957629 -SMIM19 0.323327861192079 -SPIDR 1.0712969110463e-14 -PLAT 0.000197179503033642 -CEBPD 0.540717582035749 -IKBKB 0.998786698708708 -CHRNB3 0.000131863319539552 -FNTA 0.988212601847893 -PRKDC 1 -POLB 0.000157163663858776 -VDAC3 0.970696229268312 -SLC20A2 0.864429580346683 -RNF170 0.648136150929931 -HGSNAT 1.43961491298178e-06 -KAT6A 0.999999984631619 -CHRNA6 2.0439355054386e-06 -POMK 0.000523312395933512 -THAP1 0.89916932761685 -HOOK3 0.99999800538276 -DKK4 0.0213797596918408 -AP3M2 4.4000015278485e-05 -SNAI2 0.871690015207373 -UBE2V2 0.10887932581952 -PCMTD1 2.55691827695449e-06 -FAM150A 0.00184552053934947 -RGS20 0.0162152582585256 -EFCAB1 0.000635897890174213 -ST18 0.999009547757882 -MRPL15 1.33578833013651e-05 -LYPLA1 0.00849442588120882 -ATP6V1H 3.85908994314964e-05 -OPRK1 0.0188155191797378 -SNTG1 0.0379275653329757 -TCEA1 0.342254929345763 -MCM4 0.000301842295939908 -NPBWR1 0.00013240681272579 -PXDNL 1.93677107008286e-27 -RB1CC1 0.999999798846797 -C8orf22 0.375401958677392 -RPS20 0.686321059018356 -XKR4 0.977591689560257 -IMPAD1 0.327579022336398 -CYP7A1 0.00345536122276857 -TGS1 1.02458361412861e-07 -FAM110B 0.172625630799022 -SDR16C5 0.00291744009323263 -UBXN2B 0.487567803186615 -TMEM68 0.0169369701777745 -RP1 3.68445777366637e-10 -SDCBP 0.000811571828670198 -PLAG1 0.829917236319924 -PENK 2.75735812375646e-05 -CHCHD7 0.387975837016134 -NSMAF 3.1837468420093e-08 -MOS 0.149307838238506 -LYN 0.995480464487175 -SOX17 0.866918773398146 -CA8 0.783927466808709 -RRS1 0.551023834121811 -CHD7 0.999999999999751 -NKAIN3 0.0101794431862366 -CLVS1 0.853643444640218 -YTHDF3 0.975545265361137 -ARMC1 0.876351937073404 -ADHFE1 3.87814550307822e-05 -CYP7B1 2.13811071901553e-06 -TRIM55 0.000207996390208794 -CRH 0.52778935313737 -RAB2A 0.970735512688083 -DNAJC5B 0.0096775847127486 -TOX 0.892971024523591 -BHLHE22 0.677980336838841 -ASPH 1.01766195600599e-08 -MTFR1 2.18012894299362e-05 -TTPA 0.0098843163239351 -PDE7A 0.19205771415361 -GGH 0.578462954904656 -C8orf46 0.639231507537227 -PREX2 1.00807254029751e-10 -C8orf44-SGK3 0.136791140818748 -CPA6 1.6994617793848e-09 -PRDM14 0.968775953486552 -CSPP1 3.27686488216766e-13 -MYBL1 0.998332687390342 -SULF1 0.879274682816298 -C8orf44 0.0169402857224386 -ARFGEF1 0.999999909436541 -C8orf34 9.85328956909529e-06 -SLCO5A1 1.52377907757975e-05 -VCPIP1 0.999341018273703 -MCMDC2 5.68685507134259e-06 -SGK3 0.136832560084944 -NCOA2 0.999997381929581 -COPS5 0.994339560596831 -PPP1R42 0.0127465309535919 -TRAM1 0.676696973918678 -TRPA1 9.96588682289508e-23 -KCNB2 0.954615847239045 -STAU2 0.950439190486362 -RDH10 0.934320138948288 -SBSPON 5.95163270931251e-05 -XKR9 3.6097329382333e-08 -LACTB2 0.000281761255835968 -UBE2W 0.954557960872144 -TMEM70 0.00324098348148041 -TERF1 0.878033579613451 -MSC 0.673682720909904 -LY96 2.41002321572206e-06 -RP11-383H13.1 0.0410465960747765 -TCEB1 0.643993932413181 -RPL7 0.991153031565654 -EYA1 0.955704570459788 -MRPS28 0.000355479735890669 -FABP5 0.09583820082204 -ZC2HC1A 0.811433032279189 -PKIA 0.254973075890028 -HNF4G 0.544634189825221 -CRISPLD1 0.000148412019623545 -HEY1 0.916104730437935 -IL7 0.879873742046463 -ZBTB10 0.881586182628026 -ZFHX4 0.999999642290115 -PEX2 0.0555564811475487 -ZNF704 0.972642496818876 -PAG1 0.0108372777343039 -STMN2 0.932287578199384 -GDAP1 0.000184528849113524 -TPD52 0.00511208310791974 -PI15 0.00430939169683863 -JPH1 0.706129632533951 -PMP2 0.0339817010706723 -LRRCC1 5.39715886159611e-19 -FABP9 0.000340176944486432 -IMPA1 0.0175360055513113 -CA13 0.000339444426113696 -FABP4 0.00492564212941202 -CA3 4.68813817881995e-05 -RALYL 0.0296900360975372 -SLC10A5 0.000395027314980564 -CA1 3.77366091172667e-05 -CHMP4C 0.00183040997493416 -E2F5 0.0263290981712336 -FABP12 0.00294556959022277 -ZFAND1 0.000588040962386689 -CA2 0.100369922719721 -C8orf59 0.0427259485219979 -SNX16 4.22457640928623e-08 -TMEM64 0.157412876273051 -MMP16 0.916974083764173 -PSKH2 1.74383885343745e-07 -NECAB1 0.377811814333756 -TMEM55A 0.0219903647102958 -DECR1 1.66744250187555e-05 -CNGB3 8.86463595476286e-11 -NBN 1.74403595456629e-10 -RIPK2 0.554263285932167 -RMDN1 8.90570887997982e-07 -SLC7A13 4.70688995096023e-15 -OSGIN2 0.988642484366364 -CNBD1 2.81654403463771e-10 -OTUD6B 6.25843988413621e-08 -CPNE3 5.16184252829367e-13 -CALB1 0.898924669499301 -WWP1 0.956844283836257 -ATP6V0D2 2.36746090830609e-08 -DCAF4L2 0.0016494438654563 -INTS8 0.989948635386659 -GEM 6.12905425295423e-06 -RUNX1T1 0.999121687972463 -RBM12B 0.120424618919486 -KIAA1429 0.999441598833336 -FAM92A1 3.68953972008855e-05 -CDH17 2.80756011028863e-06 -RAD54B 8.51438445753387e-10 -TMEM67 1.21202254456235e-17 -SLC26A7 3.32458521232632e-08 -DPY19L4 1.51116557898014e-15 -PDP1 0.340047357623312 -ESRP1 0.999134056583357 -NDUFAF6 2.90617936538145e-05 -NIPAL2 5.79287299169819e-06 -CPQ 7.3007030738252e-10 -POP1 2.42370810234407e-08 -C8orf37 0.0021844296064522 -RPL30 0.77479016788703 -MATN2 7.29384689107479e-09 -UQCRB 0.206960117710418 -PTDSS1 0.857749191896846 -LAPTM4B 3.42948861043789e-05 -SDC2 0.579949600907069 -CCNE2 0.338179975892655 -MTDH 0.721809341419168 -TP53INP1 6.85854635079359e-05 -C8orf47 0.000337507188161007 -PLEKHF2 0.749566016857493 -TSPYL5 0.852598058180395 -GDF6 0.910386172281508 -MTERFD1 8.34343761139148e-06 -HRSP12 0.281991269003249 -NCALD 0.817423495231911 -RGS22 1.18909888570947e-20 -RNF19A 0.0270760961169109 -YWHAZ 0.817170005056014 -VPS13B 9.81062330211603e-27 -POLR2K 0.0117782524449014 -GRHL2 0.999880613176069 -ZNF706 0.21628195162679 -PABPC1 0.999692442888147 -STK3 5.73733703569325e-09 -UBR5 1 -RRM2B 0.157235868251287 -FBXO43 0.000150255023791678 -KCNS2 0.528896630632781 -ANKRD46 0.918715846360714 -SPAG1 2.32516545713077e-07 -OSR2 0.56668220898551 -COX6C 0.230650731334253 -SNX31 1.95703250355648e-10 -ABRA 4.06005533531396e-06 -ATP6V1C1 0.142543167612395 -CTHRC1 0.00818066246056197 -KLF10 0.00342176655842149 -OXR1 0.488534430030687 -SLC25A32 7.69073648140823e-07 -ZFPM2 0.999955693827333 -DCAF13 6.92729531171936e-05 -ANGPT1 0.993331323979084 -LRP12 0.969751548793752 -AZIN1 0.991669446644311 -DCSTAMP 0.00134526640829737 -DPYS 9.89625849678714e-08 -BAALC 5.01827896369176e-05 -ODF1 0.417383751319128 -RIMS2 0.999998398615947 -FZD6 8.02772643839484e-08 -SLC30A8 1.79754250091306e-09 -RAD21 0.999544949425601 -CSMD3 0.999999995922049 -ENY2 0.797810081751442 -TMEM74 0.00033122585381911 -EIF3E 0.734231961664271 -NUDCD1 3.84054787465333e-06 -TRHR 0.265021780649127 -EIF3H 0.465051249825806 -EMC2 8.61007227016537e-05 -SYBU 0.00595342898375397 -EBAG9 0.717057362958321 -UTP23 0.033108947324346 -TRPS1 0.990109017620343 -AARD 0.328326488367201 -KCNV1 0.778125704329582 -PKHD1L1 9.12623254733104e-65 -RSPO2 0.691140450045943 -TBC1D31 1.34364593318333e-09 -DEPTOR 0.000777355950659311 -DSCC1 0.0227186261604573 -SAMD12 0.00131724341047217 -COL14A1 0.00136791753453828 -DERL1 0.0115886691978839 -MAL2 0.458862107533214 -ENPP2 0.00682819825531218 -EXT1 0.999320485111258 -MTBP 1.71020418457244e-07 -NOV 0.113896789353618 -COLEC10 0.09853673511482 -MRPL13 7.01924287122997e-07 -TAF2 0.566087060043687 -MED30 0.606541510277703 -SNTB1 0.618933425335325 -TNFRSF11B 0.272229439885372 -ZHX2 0.408482948991885 -HAS2 0.994245615539079 -SQLE 0.91297067975512 -WDYHV1 0.000384004659787212 -FAM91A1 0.515693526571197 -ATAD2 0.999997953114707 -FAM83A 0.00286574578553523 -ZNF572 0.000651450621070101 -KIAA0196 4.81024990398197e-13 -MTSS1 0.999823848176415 -FER1L6 7.9960324128331e-30 -FBXO32 0.972568188048745 -KLHL38 3.93864930044432e-06 -ZHX1-C8ORF76 0.00105203127523669 -TMEM65 0.594652549330275 -TATDN1 1.72640600686597e-08 -C8orf76 1.71944218858493e-05 -RNF139 0.0608738334958745 -TRMT12 0.942425529132779 -NDUFB9 0.0428894468164687 -ZHX1 0.821482966948104 -ANXA13 0.00725652255849584 -EFR3A 0.00926619083230622 -TRIB1 0.606587656595858 -FAM49B 0.996856902184787 -SLA 0.722953169634171 -ASAP1 0.999983091251179 -TMEM71 4.16584061056541e-10 -NDRG1 0.0538232412513876 -WISP1 0.00332828025066983 -GSDMC 9.34939571735548e-12 -FAM84B 0.0156910063345731 -LRRC6 8.29727962409699e-08 -POU5F1B 7.27271426587485e-07 -OC90 8.16819622863985e-09 -NSMCE2 0.0724507212755206 -ADCY8 0.0029856615213929 -TG 2.62956477021395e-29 -KCNQ3 0.985604293672352 -PHF20L1 0.99991198433104 -GPR20 0.315068599677581 -TSNARE1 3.60235223112282e-07 -KHDRBS3 0.868289437076458 -PTP4A3 0.127669884218514 -COL22A1 8.25832618148535e-32 -SLC45A4 0.00458960961270734 -ZFAT 0.00292867269376687 -FAM135B 0.999998682401374 -TRAPPC9 5.76038953455576e-06 -ARC 0.920765733774356 -KCNK9 0.126993745644894 -DENND3 0.0171730327867355 -ST3GAL1 0.59355924559558 -BAI1 0.999875311419222 -PTK2 0.999992957786805 -AGO2 0.999992248962312 -CHRAC1 0.658094860543726 -GLI4 0.00102128735288296 -C8orf31 1.08582352031841e-05 -LY6H 0.46060556878133 -TOP1MT 1.63072339882279e-19 -LYPD2 0.0633022046112556 -ZNF696 0.00597972241429247 -LY6D 0.000620135417616238 -GML 0.439134841904715 -CYP11B1 0.00143393188162045 -GPIHBP1 0.023780962945537 -CYP11B2 3.92718052728051e-13 -LY6E 0.733420181505572 -THEM6 0.0242798295662762 -ZFP41 0.000671957504039482 -RHPN1 1.30045250011161e-06 -LY6K 0.000583632193494971 -PSCA 0.00894842686480651 -SLURP1 0.328314103428116 -LYNX1 0.110678246204466 -PUF60 0.849324854511446 -PARP10 0.00291131564961967 -FAM83H 0.884824710028448 -ZNF623 0.0941970020128073 -EPPK1 4.95287341529358e-21 -MAPK15 1.28603703609388e-16 -ZC3H3 0.96453876461509 -EEF1D 0.394239744215719 -PLEC 0.024936270552365 -PYCRL 0.0171284135571899 -GSDMD 4.80694673198233e-07 -MROH6 1.27469283128293e-10 -ZNF707 0.0127700852104931 -TSTA3 0.0049919240345017 -NRBP2 0.00241294545324528 -SCRIB 0.91327318061127 -NAPRT1 9.84204377802944e-13 -TIGD5 0.000172428541029168 -DGAT1 2.90054760621977e-10 -SCRT1 0.294251146505632 -SHARPIN 0.0198873358156404 -GRINA 0.757342473317658 -SPATC1 3.5903133043143e-08 -CYC1 0.979014367766699 -MAF1 0.794024579551437 -TMEM249 0.341068399494477 -OPLAH 2.99003379437065e-11 -BOP1 0.526839488528947 -MROH1 0.587142254682183 -HSF1 0.586374294516982 -EXOSC4 0.0994501752994272 -GPAA1 2.89309136314948e-07 -ZNF251 3.06038920043107e-06 -ADCK5 0.908275225235627 -FOXH1 0.0132911961348389 -LRRC14 0.00665273421562502 -VPS28 0.115974874224198 -FBXL6 3.69520806815842e-06 -PPP1R16A 0.0476703373113261 -C8orf82 0.00666763298298849 -ZNF34 0.246110577926244 -CPSF1 0.0011044541536769 -LRRC24 0.775315502193512 -ARHGAP39 0.00168179647156594 -KIFC2 0.00134057888635577 -SLC39A4 0.00573736084471825 -SLC52A2 0.0119600051418378 -TONSL 6.06324987077416e-05 -GPT 2.84324204580575e-15 -MFSD3 2.01615229921387e-08 -CYHR1 0.0538307875149217 -ZNF16 4.586333335148e-12 -ZNF517 2.00971919308343e-05 -ZNF250 0.0676198881241094 -RPL8 0.93269341315758 -COMMD5 0.000302003112131852 -C8orf33 6.35413220057411e-05 -ZNF7 0.000238233955048981 -CDC37L1 0.935601045748761 -SMARCA2 0.999998263539487 -C9orf66 0.000775174366698502 -DMRT2 0.46093942790113 -AK3 5.63208744451123e-05 -GLIS3 0.000100596771327456 -DMRT3 0.00137345213214081 -DOCK8 0.00013543398043996 -SLC1A1 0.00127116672107192 -CBWD1 0.642141452095713 -PPAPDC2 0.810402576661217 -DMRT1 0.683592810352089 -RFX3 0.999773274384127 -KCNV2 6.27109599144588e-17 -RCL1 0.948080583071813 -SPATA6L 1.92357114676295e-11 -VLDLR 0.000865740605897974 -KIAA0020 1.66222046244305e-14 -MLANA 1.07616714222612e-08 -RANBP6 0.0417425099168488 -TMEM261 0.000777639943629337 -INSL4 2.05845917461986e-05 -CD274 0.00468160279332483 -UHRF2 0.999646143660092 -KIAA1432 0.804233369730465 -RLN2 5.04438325121297e-05 -TPD52L3 0.163388307107127 -PLGRKT 8.35916111034872e-08 -INSL6 4.56932984256453e-05 -ERMP1 4.54996963090227e-05 -IL33 1.05455841268217e-08 -GLDC 4.8794486364637e-14 -KDM4C 0.000758734602622751 -PDCD1LG2 0.000429826390067904 -RLN1 0.000528756556393035 -JAK2 0.969034926832703 -PTPRD 0.999999982037603 -PSIP1 0.946350057562085 -HAUS6 6.60892812829788e-10 -ZDHHC21 0.0512303788505532 -TTC39B 1.06813738722138e-11 -FAM154A 2.674971380453e-18 -TYRP1 4.48055884907162e-21 -LURAP1L 0.0766242694095508 -ADAMTSL1 8.82648695835544e-05 -SNAPC3 5.53901197607186e-05 -BNC2 0.999465645265111 -NFIB 0.990809167018789 -SH3GL2 0.916295307104429 -CER1 2.57822812120588e-05 -RRAGA 0.291376609279646 -FOCAD 5.37298120474939e-16 -PLIN2 1.19940435129965e-05 -SLC24A2 0.0350598258476389 -RPS6 0.789114983445045 -MLLT3 0.99559104959863 -DENND4C 0.406967594357299 -IFNW1 0.00616591505034941 -PTPLAD2 0.0044327552335192 -IFNA17 0.00702582209296288 -ACER2 0.146646886780043 -IFNA5 0.00683606087118389 -IFNA10 0.00187253447928596 -IFNB1 0.0136944375935193 -IFNA21 8.62552167583039e-08 -IFNA16 0.00656986926455156 -KLHL9 0.988339534912071 -IFNA4 0.240444347478374 -IFNA7 9.01848744740703e-05 -IFNA6 0.000913991156173349 -MTAP 0.000179316285483304 -CDKN2A 0.357648776382819 -PLAA 0.648657498456697 -EQTN 1.33350036518987e-07 -IFNE 8.78738642634286e-07 -CDKN2B 0.281057556695991 -CAAP1 0.708931875446252 -IFNA13 0.711459503244693 -TUSC1 0.324671553271701 -TEK 0.999992784331617 -IFNA8 2.11513003983028e-06 -MOB3B 0.0303777770401778 -LRRC19 5.16703198852798e-05 -DMRTA1 8.38884762019811e-05 -ELAVL2 0.972927704179956 -IFNA2 0.0445894041680805 -IFNA1 0.711485383815355 -IFT74 9.26889343173298e-06 -B4GALT1 0.486324787710792 -NDUFB6 0.0472184480336986 -DDX58 1.08821627751063e-14 -SMU1 0.998978044438405 -TAF1L 0.119270692068056 -ACO1 3.56928434859223e-08 -NOL6 0.999078031560119 -APTX 7.72907188264723e-06 -IFNK 9.61085354448357e-09 -SPINK4 0.713655355930809 -NFX1 0.386441238708853 -AQP7 1.86009112555737e-09 -TOPORS 0.975842586892896 -CHMP5 0.259054926516174 -LINGO2 0.807167303861535 -TMEM215 0.0082158266283866 -AQP3 0.504827505452393 -C9orf72 0.000715131762650573 -DNAJA1 0.260111368523282 -UBE2R2 0.908519448838349 -ARID3C 6.787321200931e-07 -GALT 0.00119073949704641 -KIF24 7.56461062195694e-14 -DCAF12 0.00348556415870117 -C9orf24 1.68680241907127e-05 -DCTN3 0.020223961561602 -NUDT2 0.00236774773837517 -PRSS3 4.79797626819515e-10 -UBAP1 0.952984527092159 -SIGMAR1 0.125068129498213 -RPP25L 0.834923218511704 -FAM219A 0.2726030357487 -CNTFR 0.906207074768488 -UBAP2 0.989509350398503 -ENHO 0.113449545869116 -DNAI1 0.0001273439173132 -ANKRD18B 0.00748014663853119 -IL11RA 3.74046234601675e-17 -KIAA1161 5.13052574184938e-10 -CCL21 0.110386513859901 -RUSC2 0.999977319884014 -TESK1 0.999003534885551 -CCL19 0.317197583093149 -STOML2 0.529200678276011 -FAM214B 0.387716111489972 -FANCG 9.75294817310612e-09 -UNC13B 6.60361794417271e-05 -SIT1 0.0354131319355265 -FAM166B 3.8532046326348e-06 -C9orf131 3.48248704048122e-13 -VCP 0.999992047388692 -KIAA1045 0.892271220153409 -CCL27 0.0168894105374168 -CD72 0.956612026422468 -PIGO 1.12529315374815e-06 -DNAJB5 0.491267707346988 -TLN1 0.999999999998354 -CREB3 8.86997227194125e-07 -HINT2 0.000235168176378488 -MSMP 0.443121280696342 -NPR2 0.991660781814467 -GBA2 4.79266614474154e-09 -FAM221B 4.05317460075816e-06 -GLIPR2 0.000501676858537022 -SPAG8 2.74927867712799e-07 -CCDC107 1.69816301679586e-07 -CA9 4.38501915523555e-07 -HRCT1 0.158290620361276 -RGP1 1.51313055452894e-05 -TMEM8B 0.00130768857902563 -OR2S2 0.000575667126931314 -TPM2 4.59299187157402e-05 -OR13J1 1.00804374676836e-05 -RECK 0.000196797881487026 -CCIN 0.0104920413784341 -ARHGEF39 2.22010112867739e-08 -MELK 1.8665175196218e-08 -PAX5 0.984243988730267 -GNE 4.85673826932321e-07 -FRMPD1 3.5321087486031e-10 -ZBTB5 0.798455361479278 -ZCCHC7 3.37485219287985e-09 -EXOSC3 0.701888823414483 -ALDH1B1 0.000426748675847598 -TOMM5 0.588881590096298 -ANKRD18A 0.000945591321948718 -IGFBPL1 0.0085039334958594 -POLR1E 1.02878653124634e-05 -DCAF10 0.967142660986371 -RNF38 0.999390256892047 -SHB 0.744183629095086 -GRHPR 0.00013344009925403 -SLC25A51 0.0492003687342311 -TRMT10B 8.98476738851976e-05 -CLTA 0.961296504131539 -FBXO10 0.00149253162516481 -SPATA31A2 0.432354823302012 -CNTNAP3 0.0725663655548519 -ANKRD20A2 0.118527454191844 -SPATA31A7 0.481345574657339 -ANKRD20A4 0.319603989806576 -FAM122A 0.800532188149013 -CBWD6 0.26744134859198 -PGM5 0.961611244474183 -CBWD3 0.358916974871045 -PIP5K1B 0.00744304703893292 -ANKRD20A1 0.864283491882154 -CBWD5 0.534115235923079 -TMEM252 0.00364514746841679 -FXN 0.81775377252312 -PRKACG 0.00505819149155764 -C9orf85 0.00692105108649798 -APBA1 0.865841338704799 -TMC1 3.80770445106551e-07 -RORB 0.998551700707594 -MAMDC2 0.00417147485342542 -ALDH1A1 0.993850728751138 -GDA 0.998845432686572 -ANXA1 0.000442370109951712 -PTAR1 0.73155829105821 -TJP2 6.24313389627035e-07 -FAM189A2 8.91881745197623e-06 -TMEM2 1.28387737688986e-09 -TRPM3 7.73754359412344e-06 -C9orf135 1.84473133938082e-05 -KLF9 0.882452241010758 -ZFAND5 0.91258506652532 -TRPM6 0.588344973192852 -ABHD17B 0.961448199081918 -SMC5 0.980364885210913 -IDNK 0.484632918227252 -C9orf40 0.263986200149246 -NMRK1 0.00106636786756072 -GCNT1 0.0665766367898709 -OSTF1 0.666040393255519 -RFK 0.523880795224488 -FOXB2 2.39247928093334e-06 -PSAT1 2.11054344459797e-09 -PCSK5 0.000207778974917015 -TLE4 0.999921640049606 -C9orf41 0.540935217797351 -PRUNE2 3.68321629803942e-12 -CEP78 5.36028026344908e-06 -SPATA31D1 2.73056573499066e-09 -GNA14 6.82392732529186e-10 -TLE1 0.957285090965036 -RASEF 3.27123151464191e-05 -VPS13A 0.00423831123659198 -FRMD3 0.195215061672292 -GNAQ 0.984390020772814 -RMI1 0.00309709763513186 -NAA35 0.999995236725095 -GAS1 0.616849184793069 -C9orf153 0.23330732490067 -UBQLN1 0.998753261709901 -C9orf64 0.00113820304494202 -CTSL 0.00934180847585961 -CDK20 7.19398847298015e-12 -GKAP1 0.122828409976511 -NTRK2 0.999893180098198 -SPATA31E1 6.08488739187726e-21 -SLC28A3 1.9648660260768e-17 -ZCCHC6 0.999999562537735 -DAPK1 0.999700496019786 -HNRNPK 0.999782388949029 -C9orf170 1.76428978941079e-06 -GOLM1 0.00261253568459098 -KIF27 1.3496944348062e-09 -ISCA1 0.77897388347489 -AGTPBP1 0.476341243345348 -OMD 0.00235083281027152 -NOL8 4.48669269210147e-08 -NXNL2 0.477417234289534 -SHC3 0.457668718698201 -S1PR3 0.0793338897465345 -CKS2 0.383050486929908 -OGN 0.00751075016804017 -CENPP 0.0239284606585644 -SPTLC1 2.78402793024923e-07 -SECISBP2 1.29314962997414e-09 -SEMA4D 0.995825192024996 -IARS 4.34508835544123e-09 -NFIL3 0.948599643399575 -C9orf47 0.0850920101967428 -AUH 0.00725253971720532 -ROR2 0.46471860623842 -GADD45G 0.72098224781391 -SYK 0.998540058933014 -DIRAS2 0.327172252454951 -SPIN1 0.925083438998768 -BICD2 0.332593897219712 -ASPN 0.0233215368712169 -PHF2 0.994132137165918 -BARX1 0.69051609142232 -FGD3 8.70335327222514e-06 -NINJ1 0.0612939091849242 -ECM2 1.56333125806507e-06 -IPPK 0.973790826181443 -FBP2 0.00139312366455047 -C9orf89 5.82581586008619e-05 -PTPDC1 0.00209572239053366 -HIATL1 0.0239501855388986 -WNK2 0.792762080315492 -ZNF484 4.88360439462987e-09 -SUSD3 0.00319514254571766 -ZNF169 1.74927627359584e-09 -C9orf129 0.375838563772169 -FAM120AOS 0.514390706669033 -FAM120A 0.999907050343555 -ZNF510 2.36025273380781e-09 -PTCH1 0.999998857309533 -CCDC180 5.35201684379183e-22 -TMOD1 0.856622011630374 -HSD17B3 2.48712329277216e-05 -HABP4 0.00493250468368015 -FBP1 0.0985907926556028 -ZNF782 4.92957230407518e-05 -CDC14B 0.576306678785861 -TDRD7 4.56540427647574e-05 -TSTD2 1.6294589433286e-06 -C9orf3 5.19688494998789e-12 -CTSV 9.73428954621341e-06 -FANCC 5.87975059285447e-10 -SLC35D2 9.13442164129427e-05 -ERCC6L2 0.00155590713206106 -HIATL2 0.66379100159355 -AAED1 9.50774394657092e-08 -ZNF367 0.802012369199828 -TBC1D2 2.30690551887448e-08 -GABBR2 0.999790262521872 -SEC61B 0.74284023328671 -NCBP1 0.99995610858717 -CORO2A 2.57251247711706e-06 -GALNT12 0.0028256589510292 -HEMGN 3.18514258889817e-07 -NANS 0.00017687867479135 -XPA 6.116600769977e-05 -ANP32B 0.957395492721211 -ALG2 0.0206692446248705 -STX17 0.0849679795016525 -COL15A1 3.68385885743904e-06 -C9orf156 4.080842435117e-05 -TGFBR1 0.948697388130312 -TRIM14 0.0102131175441416 -ANKS6 0.000273308458823526 -ERP44 0.956751213284096 -BAAT 7.96375042041763e-06 -OR13F1 0.00023179177042085 -GRIN3A 0.123333065136569 -TEX10 0.999988106747192 -MSANTD3 0.063002985781323 -TMEFF1 0.551607065775263 -MURC 3.72846528183563e-07 -MRPL50 0.00031841038474517 -ALDOB 0.000813754198789228 -OR13C4 5.657035075097e-08 -CYLC2 5.14081582239004e-07 -OR13C8 0.0123180644765934 -PPP3R2 0.0476655036055107 -INVS 1.44663483353059e-06 -OR13C3 0.000119523876421113 -LPPR1 0.68321406548505 -ZNF189 0.00461788519238261 -SMC2 0.998014292090329 -RNF20 0.000923364699321696 -TMEM246 0.278461423575281 -OR13C5 0.624784091356639 -OR13D1 0.010955869467886 -FKTN 0.000192375264435551 -TAL2 0.488535069507167 -NIPSNAP3A 1.63591359584979e-05 -FAM206A 0.00336234418280111 -ACTL7A 6.78270698204256e-06 -KLF4 0.981049995653145 -OR13C9 0.0436652352628204 -OR13C2 0.0443479877615874 -ACTL7B 6.59958139173351e-05 -IKBKAP 1.20456829864128e-08 -ZNF462 0.999999998400102 -ABCA1 0.00165880319635912 -SLC44A1 0.999253571367297 -NIPSNAP3B 0.0238829678663823 -RAD23B 0.973409007097557 -TMEM38B 0.1687999661801 -PALM2 0.00389317095880877 -TMEM245 0.000362236651362455 -TXNDC8 0.835982582435059 -KIAA0368 0.999999935694415 -PTGR1 0.0442771156840298 -MUSK 8.17346413889496e-05 -OR2K2 0.00146151785432729 -FRRS1L 0.00842827995041548 -CTNNAL1 2.30659700336349e-06 -LPAR1 0.00141898105564211 -EPB41L4B 0.999700026887568 -DNAJC25-GNG10 0.00277817399396608 -C9orf152 0.00474768063508639 -AKAP2 0.0665164408552921 -PTPN3 0.000188227651000982 -ZNF483 0.413497358830604 -SVEP1 0.589007650495336 -DNAJC25 0.00562063467846135 -TXN 0.417886376366376 -PALM2-AKAP2 0.0665179535302839 -UGCG 0.982568591990549 -PRPF4 0.999643089192096 -WDR31 5.53967209469172e-06 -SUSD1 8.56399035687766e-09 -SLC31A2 2.78117305043228e-05 -SLC31A1 0.519265077977303 -SNX30 0.970626802540167 -CDC26 0.646600813692917 -C9orf84 4.96930426660693e-16 -PTBP3 0.978776733356337 -BSPRY 9.78555675234067e-05 -HDHD3 0.005551021155164 -KIAA1958 0.0490021397440159 -SLC46A2 0.000292933739775045 -ZFP37 4.10777184988061e-09 -FKBP15 1.84755802385896e-07 -GNG10 0.000310150416814466 -RNF183 0.0375935013159203 -HSDL2 3.95214567435055e-05 -INIP 0.017451553253115 -AMBP 4.48294573237029e-10 -ATP6V1G1 0.0451736710316889 -POLE3 0.0777453985625654 -RGS3 9.68169038709646e-05 -ZNF618 0.994715996591424 -DFNB31 0.0110884966572566 -ORM2 0.0050434836061214 -TNC 1.4524742493256e-05 -COL27A1 0.999999360727437 -C9orf91 0.000442176335696461 -ORM1 0.13235751069872 -TNFSF15 0.364139465628525 -ALAD 0.062950260359489 -DEC1 0.000209448507541278 -C9orf43 2.99765253312802e-08 -AKNA 0.0285257400281318 -PAPPA 0.967751416645701 -TNFSF8 0.852776651355479 -KIF12 1.78101316758064e-05 -RAB14 0.973482565196718 -MORN5 0.00166333543671728 -TTLL11 0.0182318373613278 -MEGF9 0.921919104573547 -PHF19 0.995642238517627 -DAB2IP 0.999652087746425 -C5 5.61068968015523e-11 -PSMD5 1.26579691239429e-05 -TRAF1 0.0567442890552586 -STOM 0.000669922832797632 -CNTRL 4.16998709620411e-35 -TRIM32 0.0973176435273222 -ASTN2 0.989172283780343 -GSN 3.18617651517055e-06 -TLR4 4.18065301209718e-06 -CDK5RAP2 5.70875541213003e-16 -FBXW2 0.976204028260448 -NDUFA8 0.202476373061858 -BRINP1 0.995424257691719 -PDCL 0.3120279698914 -OR1L8 0.325912944324476 -PTGS1 6.4126306324781e-06 -MRRF 3.57943059722468e-05 -OR1L4 0.0431650560794194 -OR5C1 0.000111246308040193 -RBM18 0.0380098730683964 -OR1N1 0.00294378453634941 -LHX6 0.948528052712538 -OR1Q1 0.000120115267773362 -OR1B1 0.000898340840427638 -OR1J1 0.00802465330021941 -OR1K1 0.000145199061585828 -OR1J2 0.00168244963116285 -OR1L3 0.000337194097420875 -RC3H2 0.999999562144921 -OR1L6 0.0106956620736813 -OR1N2 0.00140501047777096 -OR1L1 0.000185743012731064 -OR1J4 0.240446421040762 -ARPC5L 0.775599153315343 -RABGAP1 0.999999799770328 -ZBTB6 0.357932618205793 -LHX2 0.946789688867038 -ZBTB26 0.0154751252760809 -DENND1A 0.904475401385969 -GPR144 0.315055470944652 -STRBP 0.999902421283963 -RPL35 0.527875068824637 -PSMB7 0.941261762860495 -GOLGA1 0.00610739448233049 -SCAI 0.999445289317284 -NEK6 0.644137660973949 -NR6A1 0.992320028072041 -WDR38 0.000345295162872057 -GPR21 0.0246511140506383 -OLFML2A 1.74427014386868e-05 -CRB2 3.46014603004443e-05 -PPP6C 0.988609353693385 -NR5A1 0.94752349831578 -SLC2A8 0.237274587723511 -MVB12B 0.622016653573598 -RALGPS1 0.999856880539416 -PTRH1 0.00158633515439893 -RPL12 0.164356184673043 -C9orf117 6.00502749216672e-06 -LRSAM1 2.92723845718058e-05 -PBX3 0.592665483652486 -ZNF79 0.0171294207080235 -ZBTB34 0.829622812482223 -LMX1B 0.82273227003236 -GARNL3 0.0210868407044144 -MAPKAP1 0.999736598475665 -ZBTB43 0.877041935440621 -STXBP1 0.999882943227088 -HSPA5 0.885688897994033 -FAM129B 0.0967032137688596 -RABEPK 4.19209227321727e-06 -ANGPTL2 0.182258216688379 -GAPVD1 0.999999871594819 -CIZ1 0.993095776092735 -ENG 0.989617028317184 -LCN2 0.000596069473927577 -TTC16 5.08132918779213e-12 -SH2D3C 0.000941187334660319 -AK1 0.654809128002237 -C9orf16 0.0164936296194712 -NAIF1 0.0225455776754148 -FPGS 0.000112877619093231 -DNM1 0.999863839316264 -CDK9 0.000275105560710601 -PTGES2 2.07241974496747e-05 -DPM2 0.0198009574006693 -ST6GALNAC4 0.00507720489655408 -TOR2A 0.0567475787024611 -SLC25A25 0.973302049193279 -PIP5KL1 4.90216675296999e-06 -ST6GALNAC6 0.00205356014302079 -FAM102A 0.430347065056518 -WDR34 3.69860491111848e-05 -GLE1 1.53824816142355e-05 -SPTAN1 0.999999999999786 -PKN3 1.47314472009515e-09 -CERCAM 0.0182542487737662 -TBC1D13 0.611736246776985 -ODF2 0.365893592358874 -CCBL1 6.50937611869334e-08 -SLC27A4 0.00122183971500027 -TRUB2 0.00149570183624144 -ZER1 0.998769062850375 -COQ4 0.000292854581816104 -ZDHHC12 0.0117662276069055 -SET 0.963364279903668 -C9orf114 0.104849793965415 -URM1 0.498052547084336 -SWI5 0.0263593312558164 -ENDOG 0.00624335330071762 -GOLGA2 0.994925568732598 -PRRX2 0.305924077055442 -DOLK 0.0576024421193242 -NTMT1 0.40245053975409 -CRAT 3.45790827945061e-07 -NUP188 0.987079307345649 -SH3GLB2 0.370053036389675 -C9orf78 0.117679601576605 -PPP2R4 0.983923153384693 -IER5L 0.829266816302918 -PTGES 0.624659346812814 -ASB6 0.00464633688363772 -LRRC8A 0.916104676238055 -PHYHD1 5.93053456347448e-10 -C9orf50 7.27866245193078e-10 -DOLPP1 0.604058624199982 -FNBP1 0.846297745604282 -FAM73B 0.0035189659568434 -USP20 0.00188749026993717 -TOR1B 0.743694124428476 -TOR1A 0.16704849102676 -PRDM12 0.297870330270587 -NCS1 0.947220876195482 -FUBP3 0.86267942485269 -ABL1 0.999882701417156 -PPAPDC3 0.810567266409024 -GPR107 0.839149575740717 -ASS1 0.000493337976371257 -QRFP 0.00762334929561819 -PRRC2B 0.99999910432668 -LAMC3 9.82326673498679e-11 -UCK1 0.00212663067332242 -RAPGEF1 0.999914749689066 -FAM78A 0.480800490723991 -NUP214 0.993841692882668 -POMT1 4.99835474252924e-10 -AIF1L 0.0330739002216349 -FIBCD1 7.56460038005606e-06 -EXOSC2 0.0040898062988956 -GFI1B 0.0128387744473726 -AK8 1.50735950671094e-07 -TSC1 0.999978334212389 -SURF6 8.12446562293265e-05 -MED22 0.00632213991393259 -GBGT1 0.000100077199027406 -BARHL1 0.0384385890309819 -C9orf171 5.9147238133923e-07 -DDX31 2.75575676923568e-06 -NTNG2 0.829583230038295 -GTF3C5 0.00274002234197739 -GTF3C4 0.0149762555569875 -TTF1 1.47325071683527e-06 -C9orf9 0.212814053223936 -OBP2B 0.182972936041483 -RALGDS 0.296706347503849 -SETX 0.200249583810895 -RPL7A 0.979405408797334 -CEL 6.34004798807079e-05 -MED27 0.00360424731766106 -SLC2A6 0.000366664150450035 -TMEM8C 0.00216915928417017 -BRD3 0.766979379296961 -SARDH 8.19688048123126e-10 -VAV2 0.00251877000405443 -DBH 2.54160922305115e-06 -SURF1 1.02063910629184e-13 -REXO4 9.99455362636825e-06 -FAM163B 0.428150995206124 -SURF2 3.07087198881956e-07 -COL5A1 0.999999999999752 -ADAMTS13 7.88296728194754e-11 -ADAMTSL2 0.0710586670580913 -C9orf96 2.54706971388686e-16 -CACFD1 0.00574676872876184 -SURF4 0.686424182931678 -WDR5 0.99870216011753 -FCN2 1.93230355683024e-09 -FCN1 1.2564580969204e-11 -RXRA 0.943607122852813 -PPP1R26 0.985547303285213 -GLT6D1 0.00318828821641753 -OBP2A 0.000133913764845764 -CAMSAP1 0.753664482005709 -NACC2 0.13460734119916 -PAEP 0.0316183735787673 -GPSM1 0.00214952675934529 -QSOX2 0.00783061284578592 -LCN9 0.0148717290734386 -SOHLH1 0.0104189866654002 -C9orf69 0.496755436370346 -C9orf116 0.0100326018329181 -LHX3 0.158417722579245 -MRPS2 0.0372234054354855 -UBAC1 0.865452586951363 -OLFM1 0.935993730569587 -LCN1 1.90926015198603e-07 -KCNT1 0.00534873818795492 -LCN10 0.00212801263084344 -DNLZ 0.00894156460568737 -TMEM141 0.0991119722986669 -AGPAT2 0.000150355052372305 -LCN15 0.0068805976606108 -C9orf163 0.0550466033843523 -CARD9 2.29038097230092e-11 -FAM69B 0.00357715901222349 -LCN8 0.042675811681238 -SEC16A 0.687007221303222 -INPP5E 0.388563848233216 -NOTCH1 0.999999994320622 -KIAA1984 0.000582460692550357 -RABL6 0.970513087651376 -PMPCA 0.000186050485171578 -EGFL7 9.26440008429184e-13 -SNAPC4 2.00808955575167e-21 -SDCCAG3 1.37769738127372e-07 -LCN6 2.55253161126526e-05 -MAN1B1 2.62916999838095e-06 -CLIC3 0.000387773349058043 -C9orf139 1.55539634643458e-06 -ABCA2 0.999999515728741 -UAP1L1 0.00112977007873698 -TRAF2 0.996480874852948 -SAPCD2 0.00479900889045619 -FUT7 0.905391611564477 -ENTPD2 9.49154003624772e-07 -EDF1 0.908576775721659 -MAMDC4 2.5961065070387e-35 -PTGDS 0.00887038851736075 -C9orf142 0.569785721445569 -LCN12 0.00153203676033422 -PHPT1 0.0043396321806158 -FBXW5 1.16272334357727e-08 -C8G 1.63182991085726e-09 -LCNL1 0.00301595115191131 -NPDC1 0.703401664363711 -NELFB 0.748854269451641 -TMEM203 0.500301666052416 -TOR4A 0.215534135723215 -FAM166A 1.69745841119407e-11 -TMEM210 0.313442754852511 -NRARP 0.150570049374677 -SSNA1 0.00800260908344484 -GRIN1 0.972708946068042 -ANAPC2 0.987268624004797 -TUBB4B 0.929541173942078 -RNF208 0.603529096049194 -EXD3 1.18854775167792e-08 -NDOR1 2.60774272635224e-05 -SLC34A3 2.02896416643879e-11 -C9orf173 3.9371530786687e-11 -DPP7 2.02498204002921e-15 -LRRC26 0.028439437509515 -PNPLA7 6.22823670158545e-27 -ZMYND19 0.879391539340359 -NOXA1 4.73427762914004e-06 -ENTPD8 1.72250124679312e-07 -DPH7 4.37594731994362e-05 -NSMF 0.0465461743281801 -ARRDC1 0.000232262782397713 -MRPL41 0.213388424979656 -C9orf37 0.0214340283604266 -CACNA1B 0.982603443138066 -EHMT1 0.99999990401202 -IDI2 6.34065398267436e-09 -AKR1E2 6.35197354907988e-06 -IDI1 0.00205000884385519 -WDR37 0.996766802999974 -GTPBP4 0.999865566823629 -PITRM1 7.16194900224229e-16 -DIP2C 0.999999838277401 -LARP4B 0.999885803939474 -TUBB8 0.266953543410632 -AKR1C1 8.39898077933769e-06 -AKR1C3 1.07139398635711e-11 -PFKP 7.08342752970718e-15 -UCN3 0.508143909845209 -ADARB2 0.738168861452959 -ZMYND11 0.999963586350186 -AKR1C4 1.68467759451019e-10 -KLF6 0.925053295453051 -AKR1C2 0.00410317193583082 -FBXO18 0.755821847790508 -FAM208B 0.96506326510446 -NET1 0.0668541946676421 -CALML5 0.53657959921762 -ITIH2 7.06617629312369e-10 -RBM17 0.998602405364789 -IL2RA 0.881288719632373 -KIN 0.00322198747938574 -TAF3 0.995125179714143 -PRKCQ 0.967595405937699 -ITIH5 5.63852864594726e-13 -ANKRD16 2.5777043745873e-06 -ATP5C1 0.425803630820125 -IL15RA 3.17110849041528e-08 -PFKFB3 0.0489318118268948 -SFMBT2 0.996407769866383 -GDI2 0.98715482475951 -CALML3 0.0379249704063146 -TUBAL3 0.000170843012375288 -ASB13 0.25715636307997 -SEPHS1 0.979964054551001 -UCMA 1.84529777389669e-07 -ECHDC3 0.000536785623378491 -PHYH 1.80976025439547e-05 -CAMK1D 0.99380705214431 -BEND7 0.01119032203323 -UPF2 0.99999826926484 -CELF2 0.998785801473528 -PRPF18 0.099443258781573 -MCM10 5.09300719404944e-11 -CDC123 0.239628030246869 -AL138764.1 0.0957064845042253 -USP6NL 0.102392914785226 -GATA3 0.882718840964597 -NUDT5 0.0094606868155339 -DHTKD1 1.97824193673953e-16 -SEC61A2 0.950042172255429 -CCDC3 0.000821908073152066 -PROSER2 0.00546315143684282 -OPTN 4.99023423032989e-07 -PTER 2.38597256347762e-10 -MEIG1 0.0531737986074582 -ACBD7 0.0863366080379718 -CUBN 3.03432572949695e-28 -HSPA14 0.991685161782873 -C1QL3 0.718803251749119 -RSU1 0.0477656793520055 -RPP38 1.68152550937737e-05 -C10orf111 0.035674990458653 -CDNF 0.000111034121691279 -DCLRE1C 0.00286935735912744 -FAM171A1 0.987016297989282 -SUV39H2 0.910307361240509 -TRDMT1 1.67244828325926e-06 -ITGA8 5.01886012783355e-08 -NMT2 0.317678321422733 -FRMD4A 0.999986541343185 -OLAH 0.00132846389180959 -FAM188A 0.629692867941796 -FAM107B 0.00019611623707521 -CASC10 0.02005486166772 -PTPLA 0.278082271575576 -NSUN6 1.72775122895768e-14 -EBLN1 6.91019370514168e-05 -NEBL 5.76983793061894e-24 -COMMD3 0.00742011460272826 -VIM 0.959386089206453 -ST8SIA6 2.70748990652578e-08 -DNAJC1 1.42208526512983e-08 -C10orf113 0.00753778234040987 -MLLT10 0.999583699307582 -STAM 0.902578080850864 -CACNB2 0.00182033784193924 -MRC1 0.975871402342468 -ARL5B 0.463976138130045 -SLC39A12 0.000292985871332697 -PLXDC2 0.613047816780497 -GPR158 0.678504824963118 -C10orf67 1.97204391780943e-06 -GAD2 0.898626707693029 -ENKUR 9.60808494268811e-06 -COMMD3-BMI1 0.0225993476495416 -APBB1IP 0.594392028430969 -MYO3A 6.58594533648526e-30 -MSRB2 0.00424761100040581 -ARHGAP21 0.999946673207153 -ARMC3 4.53373054750587e-08 -THNSL1 5.61830090821939e-12 -SPAG6 7.41292381390175e-06 -KIAA1217 0.0141678943279396 -PIP4K2A 0.788196366835575 -BMI1 0.515144747396546 -PRTFDC1 5.27828246084182e-09 -ABI1 0.632775183188113 -MKX 0.882320086401519 -BAMBI 0.00217665588048022 -MPP7 8.57971709426373e-07 -ACBD5 0.061645689531942 -LYZL1 0.0486957459732464 -SVIL 0.999399704010116 -ARMC4 3.96230149060258e-15 -MTPAP 0.91057549736558 -LYZL2 3.25974148951073e-06 -WAC 0.999891942627968 -PTCHD3 6.38190348669616e-11 -RAB18 0.955008594637843 -KIAA1462 0.104293752088672 -YME1L1 0.994242144818157 -MASTL 1.08232471911869e-08 -ANKRD26 7.08727863800569e-15 -MAP3K8 0.870951295340519 -PDSS1 0.263151860027171 -PARD3 0.938527049620697 -ANKRD30A 1.26066166278999e-23 -ZNF438 3.4556460409994e-05 -ZEB1 0.983612745475666 -ZNF37A 0.00192441523384355 -CREM 0.644423492964678 -ZNF248 0.685698353455718 -ZNF25 0.000386915993164412 -CCDC7 3.52388170883264e-09 -EPC1 0.999993177292492 -ZNF33A 0.000466480342698693 -GJD4 2.7835442829258e-05 -CUL2 0.999998410397597 -ARHGAP12 0.00231777174845934 -ITGB1 0.914111640885177 -NRP1 0.996035953147062 -CCNY 0.384469091192146 -KIF5B 0.761006987755031 -OR13A1 0.000212216731545614 -ZNF32 0.276205822566686 -ZNF485 3.53439212461835e-05 -ALOX5 0.00164439332581691 -ZNF33B 2.25380897368934e-06 -RASSF4 2.04594734373322e-11 -C10orf25 0.012567313038728 -ZNF22 0.126684327200881 -ZNF487 0.381487324002118 -FXYD4 0.0524503210084792 -RET 0.999889043907306 -RASGEF1A 0.910096302244158 -CXCL12 0.118587913081985 -ZNF239 0.000867929253552217 -HNRNPF 0.864039577145677 -CSGALNACT2 0.451240634927787 -C10orf10 3.86908584231525e-05 -TMEM72 0.49453096966628 -BMS1 0.995287036407563 -NPY4R 6.11597013241374e-09 -SYT15 3.40186944300935e-18 -MARCH8 1.37263384630584e-05 -GPRIN2 0.00029629113351708 -ANTXRL 0.317924027109247 -FAM21B 0.896400747509227 -ANXA8L2 0.0609064480469201 -ZFAND4 0.00925156548332018 -ASAH2C 0.655040923573138 -GDF2 0.0860071410894876 -VSTM4 0.155399626463079 -ERCC6-PGBD3 2.07309895414368e-06 -RBP3 0.0166541508510061 -ERCC6 5.00691675988158e-13 -FRMPD2 1.17402718335837e-15 -C10orf128 0.045128477576212 -LRRC18 0.00012417329035041 -PGBD3 3.01621817097075e-06 -DRGX 0.252322869969299 -ARHGAP22 0.000724652276522939 -C10orf71 9.35244270248519e-05 -ZNF488 0.000246116976810111 -GDF10 0.308234424584061 -MAPK8 0.98360211806986 -ASAH2 0.015900691207307 -TIMM23 0.597093477480232 -OGDHL 3.46920930995895e-05 -NCOA4 0.00856580592851277 -PRKG1 0.999743687068331 -SLC18A3 0.161377081657339 -ASAH2B 0.154867549921384 -CSTF2T 0.229519703844076 -A1CF 0.00361970078438154 -CHAT 0.014030306190231 -MSMB 0.0987031872923106 -C10orf53 0.00106876991334412 -SGMS1 0.89086679790325 -CDK1 0.970572339309587 -TMEM26 1.73428388598308e-07 -ANK3 0.999999999999921 -PHYHIPL 0.402880316525568 -IPMK 0.426106181687242 -C10orf107 0.000790930288586529 -UBE2D1 0.908884949778809 -CCDC6 0.967799855640717 -PCDH15 7.23123612897865e-11 -RHOBTB1 0.00183822701018375 -MBL2 0.000741511520333564 -BICC1 0.571303026474837 -ZWINT 1.33038568640096e-08 -TFAM 0.775627181230517 -FAM13C 0.000441695756137109 -DKK1 0.075574375488613 -CISD1 0.464700956103008 -SLC16A9 0.642448764557902 -RUFY2 0.416574096064703 -HERC4 0.99270709607873 -CTNNA3 6.54257200440676e-08 -ATOH7 0.0430200322640268 -ADO 0.745072785344825 -JMJD1C 0.999999999962643 -LRRTM3 0.852645121301407 -MYPN 0.065221396704038 -EGR2 0.619543204134511 -RTKN2 1.30976541627025e-14 -DNA2 1.94885128663318e-08 -ZNF365 3.62115394483978e-05 -SLC25A16 0.000247608136026081 -PBLD 2.81748273900393e-05 -SIRT1 0.951787840736877 -ARID5B 0.999889943413299 -DNAJC12 0.000104073988925761 -REEP3 0.0129812993547476 -NRBF2 0.0821062414135336 -HNRNPH3 0.996456324079282 -SUPV3L1 0.0338209971609747 -COL13A1 0.0039289675922385 -DDX21 0.998039215836896 -TET1 0.9995632776113 -TYSND1 0.0666400995988282 -KIAA1279 0.0538834564301892 -SAR1A 0.630165514404675 -SRGN 0.140766946662158 -H2AFY2 0.975641110489864 -HK1 0.555733310453426 -DDX50 0.000758121354986356 -VPS26A 0.661577283638167 -CCAR1 0.998746219854088 -HKDC1 1.84795215291941e-12 -AIFM2 1.41216409648831e-07 -C10orf35 0.0683715809117433 -NEUROG3 0.00111669288987821 -TSPAN15 0.00185580828692184 -STOX1 2.34464637366538e-07 -TACR2 9.87812061995907e-07 -LRRC20 0.136831660590252 -AC022532.1 0.0504664637507207 -SPOCK2 0.881279639448395 -SGPL1 0.122514047712303 -UNC5B 0.000746121343818483 -EIF4EBP2 0.694677115504761 -PALD1 0.000887741362023023 -C10orf54 0.385978707698929 -ADAMTS14 2.33178919110162e-06 -PCBD1 0.00109441294418619 -SLC29A3 2.99085356226281e-08 -PPA1 0.00255640189205126 -CDH23 0.0506929591139338 -PRF1 1.39812349386747e-07 -TBATA 1.68599393619126e-07 -PSAP 0.950037220630023 -NPFFR1 4.68664713029487e-09 -CHST3 0.165928594453581 -NODAL 0.947214573997477 -PLA2G12B 0.0598690316011939 -USP54 3.94252208286798e-05 -NUDT13 5.7285446566616e-07 -ASCC1 1.30497571091109e-05 -DNAJC9 0.547006457229025 -MSS51 4.16498200099113e-05 -DDIT4 0.0194954678096794 -TTC18 1.75161021605109e-05 -MYOZ1 0.00459210288836828 -ECD 1.14934390390028e-09 -MRPS16 0.0827659032788113 -ANXA7 4.616142141031e-08 -OIT3 1.03779931784183e-09 -ANAPC16 0.0725864981457658 -P4HA1 0.776076094613878 -DNAJB12 0.0399386738756349 -MICU1 1.67853966108127e-10 -PPP3CB 0.9997036494233 -MCU 0.980775509208689 -KAT6B 0.999999922573337 -DUSP13 9.99450179596282e-08 -VDAC2 0.819301260757835 -COMTD1 5.22496817166168e-06 -VCL 0.994870401764453 -CHCHD1 0.10383118057353 -NDST2 0.052949614092355 -DUPD1 1.17861404790217e-07 -ADK 0.322841314242593 -FUT11 1.25546506236405e-05 -SYNPO2L 0.0267397661792638 -SAMD8 0.00435169659402061 -SEC24C 0.999992339582229 -ZSWIM8 0.999999920857054 -AP3M1 0.768617879575058 -C10orf55 0.00506563580969443 -CAMK2G 0.994506145969444 -AC022400.2 0.49824513652403 -PLAU 0.00055026957460409 -C10orf11 0.0410566177922973 -SFTPA2 0.0145995049228688 -PLAC9 0.010238569080354 -TMEM254 0.00506595039575398 -ZNF503 0.887882312685142 -AL133481.1 0.0833915571124751 -SFTPA1 0.000541611929247931 -SFTPD 0.240356031009661 -ZMIZ1 0.999743700872505 -ANXA11 3.45820449578136e-06 -NUTM2B 0.841786847408577 -PPIF 0.00518621282700724 -DLG5 0.999998542279994 -RPS24 0.852844134621405 -POLR3A 7.38505099463942e-14 -ZCCHC24 0.473546851353267 -KCNMA1 0.999216602851545 -GHITM 0.129493357758818 -NRG3 0.210337990089114 -DYDC1 0.00206579247169306 -CDHR1 5.14858122982389e-10 -BMPR1A 0.768624359128999 -LRIT1 2.92363820811623e-08 -SH2D4B 3.12418681330873e-07 -OPN4 1.101892100262e-06 -GRID1 0.950796125986905 -TSPAN14 0.863069547941605 -LRIT2 1.82785298018402e-09 -WAPAL 0.999997764870197 -RGR 1.56159337321462e-06 -DYDC2 0.0233122399240471 -CCSER2 0.475105131344699 -MAT1A 0.754129517901618 -LDB3 0.000214849555827575 -C10orf99 0.0824467096075278 -FAM213A 0.000157315082288998 -SNCG 0.382299480507148 -LIPK 1.19029209489596e-08 -NUTM2A 0.672316972777699 -LIPM 0.169253544600704 -ANKRD22 2.03180312966558e-05 -LIPJ 2.64340955679906e-07 -LIPF 0.000753524618867874 -PAPSS2 2.50259228647192e-07 -MINPP1 0.454406266536868 -GLUD1 0.0139354648468801 -LIPN 1.70698681214155e-07 -RNLS 1.04360345149786e-06 -MMRN2 2.4897545819111e-10 -PTEN 0.975506865848027 -NUTM2D 0.227557523833091 -FAM35A 0.156586368560935 -ADIRF 0.033386817321431 -ATAD1 0.5363543151617 -ACTA2 0.734223241103143 -ANKRD1 0.000250275507071081 -STAMBPL1 1.93494634741509e-05 -IFIT3 0.00442653331666044 -LIPA 0.0112778036759298 -TNKS2 0.733760224283182 -IFIT1 0.00534820018141597 -RPP30 2.35352304647074e-05 -IFIT2 0.00148220080965614 -SLC16A12 0.00201890642213391 -PPP1R3C 0.0368811778240755 -PANK1 0.00212214971137582 -FAS 0.726173343974111 -IFIT5 0.0581423496290215 -KIF20B 6.54546380494303e-10 -HTR7 0.0340176985624909 -HECTD2 0.994416490072573 -IFIT1B 7.25641577038389e-09 -PCGF5 0.996021945517005 -CH25H 0.342292545785796 -SLC35G1 0.917135938028142 -MARCH5 0.898062228933406 -MYOF 2.08401244116976e-36 -CPEB3 0.994664051960669 -FRA10AC1 9.71537508229325e-10 -IDE 0.426771018104833 -NOC3L 1.14013419227493e-06 -HHEX 0.216268139022434 -BTAF1 0.999999999938298 -FFAR4 0.0055724932654211 -EXOC6 0.0281606351001072 -FGFBP3 0.00171216825220463 -RBP4 0.57861895575558 -CEP55 1.30065957563854e-07 -LGI1 0.997175814162011 -CYP26A1 6.64311184026187e-05 -PDE6C 7.4249966167879e-08 -KIF11 0.999996042973183 -PLCE1 0.204555596267865 -CYP26C1 0.0229549008545053 -ENTPD1 0.519393999413089 -CYP2C18 5.267291853526e-08 -TLL2 2.18060362101359e-19 -CYP2C9 2.53599347417585e-08 -CYP2C19 2.53768601148421e-10 -OPALIN 0.0606427546253694 -TCTN3 6.43975615999618e-08 -SORBS1 2.14384718511001e-08 -CC2D2B 2.5176722476543e-05 -DNTT 8.53802251177926e-05 -CCNJ 0.983940395518084 -ALDH18A1 0.855933081745869 -CYP2C8 5.35039546572966e-12 -TBC1D12 0.00264365020875562 -BLNK 0.990011101848006 -PDLIM1 1.38008290255861e-05 -C10orf129 0.0112101925841759 -HELLS 0.999418431126719 -C10orf62 9.87003275729534e-05 -MORN4 0.182745760595456 -EXOSC1 1.88218256844532e-07 -FRAT1 0.271480885095774 -LCOR 0.913200262247645 -C10orf12 0.979876887411768 -HOGA1 7.32776904772909e-06 -PGAM1 0.623538729209142 -PI4K2A 0.980219633327766 -UBTD1 0.777525003561891 -ARHGAP19 1.63035988922819e-07 -PIK3AP1 0.999656618843573 -ANKRD2 1.00825852488919e-06 -TM9SF3 0.999654187290714 -SLIT1 0.999930815097543 -MMS19 0.831821999461453 -ZDHHC16 0.0180658269032166 -ARHGAP19-SLIT1 2.95389171915188e-07 -FRAT2 0.630848044064571 -RRP12 4.36448365338862e-06 -SLC25A28 0.765079077823325 -GOLGA7B 0.0104883753574862 -HPS1 5.9907099496673e-07 -DNMBP 1.15012174102811e-09 -COX15 2.16295028243055e-09 -SFRP5 1.17131762074183e-05 -CRTAC1 0.000140635307914693 -AVPI1 1.07449770214276e-05 -LOXL4 2.14099281310303e-09 -PYROXD2 8.99028044954632e-08 -R3HCC1L 2.88113627340706e-05 -ZFYVE27 0.00370395320426504 -ABCC2 3.36341398926312e-29 -ENTPD7 2.56620119878035e-08 -HPSE2 1.85176194871334e-06 -CUTC 0.0204865647949904 -NKX2-3 0.802089179396299 -CNNM1 0.906070593117324 -GOT1 0.129221467229635 -HIF1AN 0.867690854822548 -PKD2L1 6.57113540225805e-17 -SEMA4G 0.000802235120632221 -LZTS2 0.875482095891018 -CPN1 1.32620038323609e-06 -PDZD7 0.722769807735439 -WNT8B 0.485778276590173 -SEC31B 1.30061598943069e-24 -NDUFB8 0.350528579843796 -C10orf2 0.990313030047165 -FAM178A 0.016447397085142 -SFXN3 1.26901089843385e-11 -SCD 0.887398175951616 -KAZALD1 0.000335811357601351 -MRPL43 0.000110895960635175 -CHUK 0.998703705142778 -CWF19L1 5.68864368127268e-09 -PAX2 0.120234372467327 -ERLIN1 0.931709473902675 -BLOC1S2 0.0560249302301392 -PPRC1 0.999999327553735 -KCNIP2 0.018688177733799 -TLX1 0.463723105013332 -FGF8 0.927194848734189 -LBX1 0.805820728845252 -NOLC1 0.246823454180935 -MGEA5 0.71410354161128 -C10orf76 0.0553398070733845 -FBXW4 0.000691009777576757 -HPS6 0.301742441643438 -LDB1 0.879454004833888 -PITX3 0.768360298132641 -ELOVL3 0.0100893512709736 -BTRC 0.863167823590213 -NPM3 0.85917647558232 -DPCD 0.0027034038456891 -GBF1 4.12350724274109e-07 -POLL 2.24671352271532e-11 -TLX1NB 0.0193356166079286 -ARL3 0.716101006738786 -TMEM180 0.000178664408567319 -TRIM8 0.992012340638519 -SUFU 0.99916148458521 -FBXL15 0.00210111721413477 -C10orf32 0.0316378611332373 -PCGF6 0.000251716409020373 -CUEDC2 0.0719074383771385 -NT5C2 0.0521978626707803 -INA 0.29291701476286 -CYP17A1 0.0350306078051602 -AS3MT 5.09137965873753e-07 -C10orf95 0.0113912343253953 -ACTR1A 0.941234073723515 -NFKB2 0.999696457724303 -CNNM2 0.994106430518482 -PSD 0.987334022305881 -RP11-332O19.5 0.00239907188012324 -SFXN2 0.00108457408549622 -WBP1L 0.909387313715096 -CALHM2 5.29267890521713e-07 -NEURL 0.537569854397269 -SH3PXD2A 0.232738023334583 -XPNPEP1 0.964214096910664 -PDCD11 0.468448697895289 -GSTO2 1.66971146764309e-07 -USMG5 0.243352200194902 -CALHM1 9.35701997314557e-05 -WDR96 1.11043319913338e-14 -TAF5 0.999555180536955 -SLK 0.428398338221419 -SORCS3 0.325134263508276 -SORCS1 0.969565842045511 -SFR1 0.000222754704198165 -COL17A1 5.82447151365916e-11 -ITPRIP 1.35269477140853e-05 -GSTO1 0.0150378430797143 -OBFC1 1.32529699599379e-05 -CCDC147 3.42062201153183e-18 -TECTB 5.94966588308075e-09 -ACSL5 0.0167637112007589 -TCF7L2 0.98960502908944 -CASP7 0.000373926384361289 -ADD3 0.952357436631549 -DUSP5 0.0255938782141754 -MXI1 0.707739926081003 -NRAP 2.58648973238176e-31 -SMC3 0.99999999949759 -PDCD4 0.000577683801357511 -HABP2 1.17394512031747e-14 -SMNDC1 0.27579751481189 -GPAM 0.000580579250988833 -VTI1A 0.413424037513717 -SHOC2 0.991705191552454 -ZDHHC6 0.000675860139797096 -NHLRC2 0.000339054634985002 -TRUB1 0.000523645293941091 -C10orf82 0.00387838131040333 -TDRD1 0.999760761518604 -FAM160B1 0.999984985147066 -DCLRE1A 4.67768893872676e-08 -PNLIPRP3 2.75274000877155e-09 -AFAP1L2 0.446972663901368 -PNLIPRP1 6.28353313986005e-10 -PLEKHS1 1.17132107467687e-15 -ABLIM1 0.951991965239091 -CCDC172 0.00832961563746814 -PNLIPRP2 2.8556336614904e-05 -PNLIP 0.00935447108842685 -C10orf118 0.258534202161481 -ATRNL1 0.995631864108185 -GFRA1 0.119577142602515 -VWA2 2.57813515827879e-13 -KCNK18 0.000349560661258946 -RGS10 0.601559967602402 -EMX2 0.941755033342245 -KIAA1598 0.886314076883697 -RAB11FIP2 0.910707841389083 -FAM45A 0.000243198672562155 -CACUL1 0.84668696675278 -TIAL1 0.998790731658321 -VAX1 0.534984091030816 -NANOS1 0.180809141007575 -SFXN4 0.000148320455391636 -EIF3A 0.999999999560078 -PDZD8 0.997263557407283 -PRDX3 0.221688705653951 -SLC18A2 0.971755218810696 -PRLHR 0.000426453630646031 -FAM204A 0.0507124221470989 -GRK5 0.984107718022279 -HSPA12A 0.980307172080411 -NSMCE4A 0.0859469951564236 -INPP5F 0.00146883108535103 -CUZD1 5.27752199889402e-06 -HTRA1 0.0169475465900735 -ARMS2 0.0391826461982656 -PLEKHA1 0.0177773375494199 -BAG3 0.53203443022702 -ATE1 0.511356720482748 -FAM24A 0.167839101766311 -SEC23IP 0.373415107688289 -PPAPDC1A 0.184092341386933 -TACC2 3.52232783639013e-19 -MCMBP 0.998215054692028 -DMBT1 7.35516622313886e-32 -FAM24B 0.0336499409548214 -WDR11 0.070328055046955 -BTBD16 3.41362084542176e-12 -FGFR2 0.999752493022751 -C10orf120 1.29529424187308e-06 -CTBP2 0.655184958473335 -LHPP 1.59687423011584e-06 -CHST15 0.177822119661987 -HMX2 0.000305119293834059 -ACADSB 2.98832226560367e-08 -METTL10 0.371286245054088 -CPXM2 1.82592014923893e-10 -PSTK 0.00411002353042562 -C10orf88 0.0385850029121195 -IKZF5 0.422736840290601 -ZRANB1 0.99983984952777 -FAM53B 0.40047960162071 -OAT 0.000721947397616178 -HMX3 0.772661528331209 -FAM175B 0.0868521973405688 -GPR26 0.627337376565242 -C10orf137 0.000606745879282857 -BUB3 0.554686126711163 -MKI67 4.17035383841505e-16 -FAM196A 0.849026864550399 -UROS 0.0122749509635658 -MGMT 9.20505516948058e-09 -BNIP3 0.0487268463399347 -DHX32 6.96915711971685e-07 -BCCIP 0.00165485845540064 -CLRN3 0.140040446356922 -MMP21 3.21016423544875e-07 -TCERG1L 0.000228294241632806 -ADAM12 0.341608446907088 -GLRX3 0.629710154906928 -FOXI2 1.59663014247231e-05 -FANK1 0.000115654248643306 -DOCK1 0.36842317046063 -C10orf90 6.05506924127418e-11 -PTPRE 0.0100100422146958 -EBF3 0.998590013761644 -NPS 0.0001000801288686 -NKX6-2 0.0134613071846023 -TUBGCP2 5.05146960755812e-05 -PRAP1 0.000246548833965658 -TTC40 4.17911546120286e-25 -GPR123 0.51215511770856 -C10orf91 0.0743076347528587 -ADAM8 1.47656059828336e-07 -CALY 0.706613402268371 -STK32C 0.309709769270868 -LRRC27 9.74868422732027e-14 -PWWP2B 0.71615388692527 -INPP5A 0.942238413616355 -FUOM 0.00160107219629907 -DPYSL4 5.85788198919438e-06 -JAKMIP3 0.053931825098127 -VENTX 3.99153777112171e-09 -ZNF511 0.0144447040829361 -UTF1 0.150834366464766 -KNDC1 4.44328480271007e-05 -ECHS1 0.519800839729468 -RP11-108K14.8 0.0293653123812636 -SPRN 0.386597169234573 -SYCE1 0.000763634678380383 -PAOX 0.0004355557754425 -CYP2E1 0.265925587444093 -MTG1 0.0626719606528276 -FRG2B 0.152494211914454 -B4GALNT4 0.816930490785275 -IFITM2 0.299375900397776 -SCGB1C1 3.34415917228498e-05 -SIRT3 2.70051653943508e-05 -PTDSS2 0.000109482996794452 -RIC8A 0.000378552821267232 -RNH1 0.000213431930050961 -SIGIRR 0.00530888875886403 -IFITM3 0.199202473288833 -PSMD13 0.993513212124208 -PKP3 0.194350414769518 -BET1L 0.378367596560038 -IFITM5 0.000115704605462658 -ANO9 4.59377788263046e-11 -ODF3 0.586974862090879 -LRRC56 0.000110646268059748 -HRAS 0.00794104930284198 -ATHL1 3.53241578008574e-09 -IFITM1 0.221686062595446 -EPS8L2 0.00182700802996643 -RPLP2 0.708517552606227 -PIDD 1.60116343352886e-09 -TALDO1 0.000175588436662531 -PNPLA2 0.0011411925640916 -SCT 0.406650722252906 -IRF7 3.31354276199443e-07 -CD151 0.00164311219240346 -TMEM80 4.91354767098304e-05 -DEAF1 0.000193157379315308 -RASSF7 3.45003416366976e-06 -DRD4 7.58378913666363e-06 -PDDC1 0.617289947810584 -CEND1 0.584353271222879 -CDHR5 1.31307026997115e-10 -EFCAB4A 0.00185893565695636 -SLC25A22 0.568405564949865 -C11orf35 1.19218722495886e-17 -PHRF1 0.948919011202068 -CTSD 0.0891858597432503 -SYT8 7.5902706627317e-13 -DUSP8 0.6844729650101 -KRTAP5-6 0.000393980177015885 -KRTAP5-3 0.262910457239172 -BRSK2 0.779570081093511 -MUC5B 0.999999706471312 -POLR2L 0.53288051090857 -KRTAP5-1 0.000129615662038598 -MOB2 0.641498728519639 -KRTAP5-5 1.15231280702318e-05 -KRTAP5-4 0.00679370641134028 -TSPAN4 2.52434251211869e-06 -CHID1 0.000725517070552349 -KRTAP5-2 0.000625082928112611 -MUC6 1.08683766450872e-32 -MUC2 4.54632231934197e-05 -TOLLIP 0.52290626801214 -AP2A2 0.999932214597942 -KCNQ1 2.45298673885324e-05 -INS 0.730321287731717 -TSPAN32 0.000537261290250421 -TSSC4 0.0132781892109177 -INS-IGF2 0.0364414126480976 -TRPM5 7.63575945842109e-17 -TNNT3 0.00472931950180961 -ASCL2 0.388900409868869 -TH 0.00409874369425709 -TNNI2 0.0861527411924089 -CD81 0.950521598051911 -PHLDA2 0.0242596618306058 -IGF2 0.0253027183278788 -MRPL23 1.45650190962038e-06 -CDKN1C 0.522821690107795 -LSP1 0.259641696484575 -SLC22A18 0.00192306817866287 -CARS 2.96288607598974e-06 -OR52K2 1.59479439547175e-06 -ART5 0.0172264751087272 -NUP98 0.999999978537761 -STIM1 0.926766742543403 -ZNF195 0.731668924641439 -CHRNA10 1.04066746022543e-05 -OR52M1 4.69164554510947e-06 -PGAP2 0.15222416020635 -TRIM21 0.0930518154823646 -OR52K1 1.7549622716681e-05 -ART1 1.54462673964299e-09 -OR52B4 0.000229944721320279 -OSBPL5 0.000848897697066133 -NAP1L4 0.995731030115456 -MRGPRE 4.75586456400976e-05 -RRM1 0.999994803572266 -RHOG 0.600682842297036 -OR51S1 0.00381804007088034 -C11orf40 4.84556312500488e-08 -OR51E1 0.000349920575007864 -MMP26 0.0221718840532987 -OR52I2 0.0745578369232702 -OR51A2 0.645582291191579 -OR52R1 6.92486080039828e-06 -OR52I1 0.0620560888985741 -OR51D1 0.0017095838447418 -OR51E2 0.00369122591258073 -OR51T1 0.0197223467998845 -OR51G1 6.15802285365321e-05 -OR51A7 1.657185671764e-06 -OR51F2 0.000112097120181894 -OR51F1 0.0539403351067528 -OR51L1 0.0155803661202956 -TRIM68 2.15428833165883e-11 -OR51G2 0.00310073735008262 -OR51A4 0.239072288434888 -OR51B5 0.000317629351949324 -OR51B2 0.0073551857029565 -HBG1 0.0297794697176572 -OR52D1 0.00367438578175141 -OR52J3 0.00101254779687311 -OR51I2 0.00088895679609386 -OR52E2 0.0004277489192399 -HBB 1.02493118765881e-08 -OR52A1 0.00107001892950523 -OR51Q1 0.00368505396031344 -OR51V1 0.00371474051452938 -HBE1 0.0108144244545265 -OR52A5 0.000168133883560112 -OR51B6 0.00017487774428757 -OR51B4 0.0123392431471372 -HBD 0.000155107643467577 -OR51I1 0.00237702705500239 -HBG2 0.241303510098989 -OR51M1 0.253410703966009 -TRIM6 3.78638887641513e-10 -OR52N5 0.0492919635950094 -OR52N1 0.0204785353882855 -OR52N4 3.29464855948091e-05 -OR52E4 4.45011681541019e-07 -TRIM6-TRIM34 2.30605194516737e-11 -OR52E6 0.0680948880246383 -OR52N2 7.30570712567745e-05 -TRIM34 0.00020889000433714 -OR56A4 0.307699476267042 -OR52B6 0.0735885276233448 -TRIM5 4.36970250918444e-08 -UBQLNL 3.52672263535128e-09 -OR56B1 1.26988881075159e-08 -OR52H1 0.0130705992596721 -UBQLN3 0.00382806762177032 -OR52E8 0.0166920375816032 -OR52L1 0.00634036042025339 -OR56A3 7.11292351711341e-08 -TRIM22 3.15622179426349e-12 -PRKCDBP 4.93189420887156e-05 -RRP8 6.40182729629982e-06 -OR56B3P 9.25160420643862e-07 -ARFIP2 0.942932710427979 -ILK 0.0421959659732426 -TRIM3 0.952560875185986 -TIMM10B 0.00115870998097543 -OR52W1 0.000404092684374612 -HPX 0.00412144745614206 -CNGA4 9.8597680152566e-05 -CCKBR 9.67009048154741e-05 -C11orf42 3.04760565776035e-06 -FAM160A2 0.999881559428366 -OR56A1 0.263101576969007 -OR56B4 1.18644352031201e-05 -DNHD1 1.33457888519476e-18 -APBB1 0.986993652220937 -OR52B2 5.17756813877584e-05 -SMPD1 4.204719316463e-07 -MRPL17 0.464121315693857 -PPFIBP2 1.42290838281706e-18 -OR2D2 5.50847424198125e-07 -TPP1 0.0257560632861161 -NLRP14 9.14864568100148e-23 -SYT9 0.331363732407492 -OR2AG2 0.216721901668246 -OR2AG1 8.87524222679285e-06 -OR10A4 2.78490991495933e-05 -RBMXL2 0.677816820678495 -TAF10 0.77613089905454 -OR6A2 0.267851555384992 -DCHS1 0.999995437521813 -ZNF215 4.25305953478021e-13 -OR10A2 0.000920372164321628 -OR10A5 0.00842213119189341 -OLFML1 0.000497436648326104 -OR2D3 0.00308950663827612 -CYB5R2 2.70695453986963e-05 -ZNF214 2.49756188348063e-14 -OR10A3 4.36193036936385e-09 -ST5 0.99998977925639 -SCUBE2 1.4930424797099e-13 -ASCL3 0.00828397093918885 -OR5P2 0.0101383238709392 -OVCH2 7.83188711149752e-14 -OR10A6 8.59245281840639e-09 -NLRP10 5.09582300313282e-12 -RIC3 0.0122613505184732 -RPL27A 0.867199853512814 -TMEM9B 0.911174542861045 -OR5P3 0.615021497256301 -AKIP1 1.85693228183286e-05 -LMO1 0.477078993256257 -C11orf16 4.79365943685803e-06 -STK33 0.000137426345687613 -EIF3F 0.669067337550454 -NRIP3 2.34631014081811e-05 -TUB 0.471428314326012 -DENND5A 0.991775356411996 -ZNF143 0.0219669962784504 -USP47 0.999999875159451 -LYVE1 4.22095940703122e-07 -AMPD3 1.3313454680315e-08 -GALNT18 0.0476851755722948 -CTR9 0.999999446978789 -DKK3 1.88888907624104e-05 -ADM 0.576630085865165 -IPO7 0.999998374732842 -RNF141 0.00070215316465317 -TMEM41B 0.0201899312153953 -CSNK2A3 1.32371438961756e-11 -SWAP70 0.348844347370405 -SBF2 0.380054089955573 -WEE1 0.997105770017131 -MRVI1 0.00184121524712682 -CALCA 0.00139555682902756 -PSMA1 0.947988404934487 -PIK3C2A 0.14870309003261 -C11orf58 0.709037215515083 -RRAS2 0.674254313651317 -INSC 1.3427309129659e-09 -FAR1 0.87956746195825 -COPB1 0.999763440028058 -PDE3B 0.0036164696577972 -MICALCL 5.41818008026451e-16 -ARNTL 0.987642966676249 -SOX6 0.999530959870119 -MICAL2 0.132223746243123 -BTBD10 0.477320145122737 -CYP2R1 3.05144607991638e-09 -PARVA 0.343764020273313 -CALCB 0.0578761947440093 -PTH 0.270149119024624 -PLEKHA7 0.000173040691290598 -RPS13 0.960207216837053 -RP11-113D6.6 0.000556180208336132 -MRGPRX4 0.00181856462826359 -HPS5 9.07535902902917e-06 -SAAL1 0.000128876571862682 -MRGPRX3 2.86211366895334e-08 -NUCB2 8.58987882667095e-08 -KCNC1 0.70997213579973 -SAA4 0.0146359405828845 -ABCC8 3.93872340599153e-15 -TPH1 2.67305040364718e-05 -SAA2 0.0286553987840972 -SAA1 0.181814610902195 -KCNJ11 0.314724130416306 -USH1C 2.72435840434222e-12 -GTF2H1 0.995912255857913 -SERGEF 2.21836725525601e-10 -MYOD1 2.68321885548831e-05 -RP11-113D6.10 0.34890553015955 -NELL1 2.16981597021605e-09 -HTATIP2 3.64419690390924e-12 -DBX1 0.14778053659514 -UEVLD 1.09267674829095e-07 -MRGPRX1 0.0831473169654194 -PRMT3 6.29172115448445e-12 -LDHC 0.000944178486057736 -PTPN5 0.000777688142490709 -E2F8 0.995041279088296 -TMEM86A 0.0329601379578081 -ZDHHC13 2.55026685458048e-14 -CSRP3 0.00220886834015439 -LDHA 0.058657590294526 -LDHAL6A 0.000200256316758105 -TSG101 0.982720286760501 -IGSF22 1.19691570710455e-20 -SPTY2D1 0.99791521426105 -NAV2 0.997517125070282 -MRGPRX2 0.00249061218606174 -SLC6A5 1.84554624033866e-12 -FSHB 0.0128991685953233 -KCNA4 0.946234021376117 -KIF18A 0.149441082550392 -BBOX1 1.50172844518235e-12 -FIBIN 0.308532918780581 -FANCF 0.00381453403362032 -ANO3 4.08913851953925e-13 -ANO5 9.89423115964736e-16 -MUC15 3.93192149563272e-05 -LIN7C 0.0300652295135779 -LGR4 0.994112645257008 -METTL15 0.000155430996855608 -GAS2 0.0262897655046356 -SLC17A6 0.857098873242776 -CCDC34 4.91354825835912e-07 -SLC5A12 2.14726778576519e-05 -SVIP 0.0114316242536358 -BDNF 0.946719308479018 -LUZP2 8.71328292536607e-05 -PAX6 0.998807897358069 -QSER1 0.999935658653166 -CCDC73 1.19030024122162e-13 -HIPK3 0.893187377239476 -CSTF3 0.996434299674929 -FBXO3 0.969760026410035 -DNAJC24 7.24727295119377e-07 -IMMP1L 0.0207131651278836 -MPPED2 0.970565201803493 -EIF3M 0.981660594170631 -DEPDC7 1.25056837709977e-05 -TCP11L1 0.0880469871522841 -KIAA1549L 0.00370822940112543 -DCDC1 9.13494875057035e-05 -PRRG4 0.18140174334153 -ELP4 0.0125582812097109 -ARL14EP 0.151697478147144 -CD59 0.0683809188352026 -RCN1 0.0163385637096446 -LDLRAD3 0.0250893103934073 -CAPRIN1 0.999767661808702 -NAT10 1.05399824567495e-13 -FJX1 0.823951146531355 -TRAF6 0.996923826264077 -CAT 1.47983086096776e-06 -CD44 0.0082693846811732 -TRIM44 0.163653747251109 -LMO2 0.753952192768922 -APIP 4.19693047731044e-10 -ELF5 0.0190865143588019 -PRR5L 0.0787688609861764 -RAG1 0.00189800110752859 -SLC1A2 0.907792747494983 -PDHX 0.00137028838511485 -PAMR1 4.62835775540526e-21 -EHF 0.978731448718073 -COMMD9 0.635260481804229 -ABTB2 0.124650440326371 -HSD17B12 0.00555447777759886 -LRRC4C 0.953730868705953 -C11orf74 0.00762075072953251 -ALKBH3 2.55797163392014e-09 -CD82 0.00496183334104084 -CHST1 0.820990319101784 -SLC35C1 0.147014851687706 -TSPAN18 0.161860431497711 -TP53I11 0.0671742712713169 -PRDM11 0.942263570754501 -ACCS 0.00017166582720853 -RAG2 0.0105193118193894 -SYT13 0.220165778639476 -ALX4 0.23488770388706 -API5 0.9995550190637 -TTC17 0.999727593898895 -ACCSL 2.58324245379256e-11 -EXT2 2.46055407087129e-07 -ARFGAP2 0.562990971385505 -MAPK8IP1 0.999000973193662 -DGKZ 0.998142633966722 -ZNF408 7.89160984461696e-06 -ARHGAP1 0.185564722294501 -CREB3L1 0.399379409918579 -C11orf94 0.000289638176341335 -CHRM4 0.916843942226412 -CRY2 0.993283035571508 -PHF21A 0.999675486100741 -F2 0.959943187768661 -AMBRA1 0.999971640508962 -C11orf49 5.45467879227827e-07 -CKAP5 0.99999999753418 -GYLTL1B 8.27410616426457e-12 -MDK 0.0224327842650619 -LRP4 0.10020880429216 -ATG13 0.984296607292859 -PEX16 0.00174660780249164 -HARBI1 0.00570134099999797 -CELF1 0.998616884875254 -NUP160 0.023979152527532 -MTCH2 0.166788403447163 -FAM180B 0.315838165150116 -PSMC3 0.979199713289554 -PACSIN3 0.0167930476176259 -KBTBD4 0.0180743639557145 -NDUFS3 0.0471370341289045 -NR1H3 0.856185983167695 -AGBL2 6.81051045839789e-12 -MADD 0.000901823421065546 -SPI1 0.89723051716191 -RAPSN 0.0326445463388561 -PTPMT1 0.459152455272006 -MYBPC3 1.35053975034244e-06 -FNBP4 0.999993422916695 -ACP2 0.00052597665714545 -SLC39A13 0.0118520311660311 -DDB2 0.00511790717237921 -C1QTNF4 0.679081390678169 -OR4C3 0.00874513097467769 -OR4A47 1.43390782604699e-05 -OR4C46 8.76630664507137e-07 -TRIM49B 7.55661253581996e-05 -TRIM48 1.77341661947835e-14 -OR4C12 0.23821319029955 -FOLH1 0.253396884638148 -OR4B1 0.0109380186584993 -OR4C13 8.59262892850206e-09 -OR4S1 0.00461719061361746 -OR4X1 0.00015767458987061 -OR4A16 2.61340194128249e-05 -OR4X2 1.10988723254503e-08 -TRIM64C 0.012116567412189 -OR4C15 3.39409709462154e-11 -OR4C5 0.0165676629621224 -PTPRJ 2.38654353395849e-05 -OR4C6 1.0819424863645e-05 -OR5W2 0.0488123221166674 -OR4S2 0.00103860294519937 -OR4C11 1.40886744095212e-06 -OR4P4 0.0573838007216111 -OR10AG1 0.000135734106384808 -OR5AS1 0.255635872734436 -OR5L2 0.000593860863455805 -OR8H2 0.000858971946429471 -OR5D18 0.000954997598444594 -OR8J3 0.0655570233337098 -OR5L1 5.93920385495045e-07 -TRIM51 1.04917684230659e-05 -OR8I2 0.000129181427224364 -OR8H3 7.94648072869994e-07 -OR5D13 1.73555819538654e-07 -OR5I1 0.237661331801561 -OR5D16 2.33685393272016e-07 -OR5D14 0.000814344980968998 -OR5F1 0.00647381424823331 -OR8K5 4.10692348788277e-07 -OR5AR1 0.000179721317392242 -OR8J1 4.47462093270338e-06 -OR8K3 4.46100866088346e-06 -OR5T2 0.0010790748626569 -OR5M1 0.0473826725341121 -OR5T3 1.28424640234906e-05 -OR5J2 0.000124682157643135 -OR5AP2 0.0692232333224351 -OR8U1 0.0134541405146474 -OR5M11 0.000762549638271515 -OR5M8 0.00973388346897511 -OR5M9 0.00775094260115899 -OR5R1 2.18602853058181e-05 -OR8K1 0.00203916386705507 -OR8H1 1.46607275128529e-05 -OR5M10 0.0077276318820004 -OR9G1 0.00099531584115889 -OR5T1 0.000130890000678226 -OR5M3 1.24690874517497e-05 -P2RX3 0.0114975811361225 -SLC43A1 7.85327016141061e-05 -UBE2L6 0.0140103299116803 -YPEL4 0.805554819387752 -SMTNL1 6.40314836984676e-06 -OR5AK2 2.87905465610352e-07 -LRRC55 0.677224186440864 -SLC43A3 0.000317449115823233 -CLP1 0.937604668403125 -TNKS1BP1 0.0297108798308007 -APLNR 0.432459659997125 -PRG2 1.36694535208987e-05 -OR9G4 0.000306987549777873 -SSRP1 0.999693191606899 -MED19 0.683790051387125 -PRG3 0.000177440765062925 -SERPING1 0.972837398501847 -ZDHHC5 0.999924209308766 -TIMM10 0.00949476231742544 -RTN4RL2 0.975814588290454 -OR5B17 0.0772363405801556 -OR5B3 0.00100172727895397 -OR5B2 0.0056353700412876 -OR6Q1 0.00486335445142141 -OR9Q1 0.00859489705714355 -CNTF 0.000349252208597215 -OR5B21 9.44945209297068e-05 -C11orf31 0.000781712087900896 -OR1S1 0.00790090049807544 -OR1S2 0.0010633304095779 -LPXN 0.0172004433087515 -ZFP91 0.983773002727888 -TMX2 0.42991378476753 -OR9I1 0.612331301435911 -OR10W1 0.0473260213246962 -OR10Q1 0.254569448021136 -OR5B12 0.310930146470037 -OR9Q2 1.29909599868149e-07 -CTNND1 0.995312685088934 -OR5AN1 0.00117731258117152 -OR5A2 0.0014039822282672 -OR5A1 2.02941693534639e-05 -FAM111A 3.22456890783558e-09 -GLYAT 8.03824153928287e-05 -OR4D9 4.8854167946133e-05 -DTX4 0.594144205008104 -STX3 0.630609378340344 -MRPL16 0.00310865625311475 -OR4D6 0.0150121178988349 -FAM111B 7.17098815107683e-11 -OR4D10 0.0640123916557904 -OR10V1 0.00168146463399745 -MPEG1 3.45678304248647e-12 -GLYATL2 9.09624563195602e-11 -OSBP 0.999542555149074 -GLYATL1 6.26859114623908e-05 -PATL1 0.991973625774226 -OR4D11 0.000895035311998553 -CCDC86 0.00147735697356089 -MS4A7 9.27325316417502e-06 -MS4A13 0.0538658364526184 -PLAC1L 0.0217138962545513 -MS4A3 4.21112895152531e-05 -MS4A6E 0.72055108088883 -MS4A4E 0.515839923885565 -GIF 0.434202069663625 -MS4A10 1.79435429349408e-08 -MS4A6A 1.49231954313632e-09 -MS4A5 0.00920453847809139 -MS4A8 0.00260921171410416 -MS4A12 4.95569370765756e-05 -MS4A2 6.49875397938143e-05 -TCN1 3.85562988627718e-16 -PTGDR2 0.184110369283718 -MS4A4A 0.000743081971054817 -MS4A14 2.18827547869555e-16 -MS4A1 0.0153881692917396 -MS4A15 0.0384681974305748 -CYB561A3 0.0587317231678231 -TMEM216 0.00201929498374557 -PPP1R32 2.68242098295629e-07 -TMEM132A 2.88925822598835e-06 -TMEM109 0.0518905468899636 -TMEM138 0.53112115683539 -SLC15A3 3.65752302506969e-07 -DDB1 0.999992284151209 -PRPF19 0.998566695864226 -PGA5 0.00127358049246854 -VPS37C 0.197171487861635 -CPSF7 0.991330175057795 -PGA3 0.645340633938956 -DAK 2.79479210875633e-07 -CD6 0.00430465847629855 -ZP1 4.95779407104949e-10 -VWCE 5.90266495568438e-13 -SDHAF2 6.97874038276147e-05 -CD5 2.72798403763384e-05 -RAB3IL1 0.000894540821499919 -SCGB1D2 0.0961136812474541 -MYRF 0.999847803435962 -SYT7 0.904578639335977 -FADS3 0.0488722447276726 -FADS2 0.990052486204972 -SCGB2A1 0.0564012954624431 -DAGLA 0.953148342492449 -SCGB2A2 0.00892427737697349 -FTH1 0.918437494529701 -FADS1 0.383801126989728 -TMEM258 0.000864646359600505 -BEST1 4.88561552823397e-08 -INCENP 0.996086664513722 -SCGB1D1 1.19495732132787e-05 -ASRGL1 0.000386788119196688 -SCGB1D4 0.00290219205998929 -FEN1 3.47774227503768e-05 -SCGB1A1 0.00766133226097893 -UBXN1 0.768417510378765 -TUT1 9.985102139972e-06 -HNRNPUL2 0.999925394683505 -LRRN4CL 5.4372145884e-05 -METTL12 0.00946026365697049 -TTC9C 0.000139734935043785 -C11orf83 0.000546458147219791 -GANAB 0.99994841038629 -MTA2 0.978013018375655 -C11orf48 1.53758667829402e-05 -B3GAT3 0.000286974910106167 -EML3 0.394340909405705 -RP11-831H9.11 0.0791666783539495 -EEF1G 0.998058440819428 -INTS5 0.999284368233793 -GNG3 0.5272272299072 -ROM1 0.00326883045590689 -BSCL2 0.00852541052442389 -AHNAK 0.344567387106657 -HRASLS5 0.000123369757946174 -POLR2G 0.00646539515591118 -RARRES3 0.000504117067056656 -SLC22A6 2.189266123066e-05 -SLC22A8 1.50475715346013e-10 -WDR74 2.46017425068892e-08 -ZBTB3 0.243280561450218 -SLC3A2 0.923234161379885 -STX5 0.362948405820287 -NXF1 0.998990474742992 -TMEM223 0.0124355311633348 -TMEM179B 0.0107811505009859 -SLC22A10 1.54344983139895e-14 -CHRM1 0.931378496611047 -SLC22A24 0.000186760846184136 -LGALS12 2.6857353502622e-09 -TAF6L 0.819819294441314 -SLC22A9 3.61523813897635e-14 -HRASLS2 0.0182738037126763 -SLC22A25 4.63017324509406e-13 -PPP1R14B 0.709204424376776 -AP000721.4 0.136411776382316 -RCOR2 0.115753696587521 -STIP1 0.999887764233234 -OTUB1 0.945238199205908 -NUDT22 0.000315497036403361 -VEGFB 1.52262082590775e-06 -DNAJC4 6.43771101373159e-06 -ATL3 0.000317251708826362 -TRPT1 0.00867584904463919 -FERMT3 0.257005091081095 -MACROD1 0.00662476930110474 -COX8A 0.491407579691412 -PLA2G16 1.19316734661233e-05 -FKBP2 0.307159555574364 -RTN3 0.0400228226482246 -MARK2 0.999900854654153 -FLRT1 0.546319766734407 -C11orf84 0.471418765181543 -NAA40 0.00544668374828987 -PRDX5 0.00314038121761632 -NRXN2 0.999895574015252 -KCNK4 0.0424811996004613 -PLCB3 0.968376699687946 -RASGRP2 0.995280465479902 -RPS6KA4 0.99947453973056 -ESRRA 0.527244156756672 -PYGM 2.61594230276409e-08 -TRMT112 0.141017363378346 -TEX40 0.47704330239022 -CDC42BPG 1.40627803289603e-17 -CCDC88B 0.000929045236295006 -MAP4K2 6.47662241204138e-05 -BAD 0.000414578843999332 -GPR137 0.484398269659545 -MEN1 0.999190000895056 -SF1 0.998855016951352 -SLC22A11 5.80185239880571e-05 -SLC22A12 4.90101865688499e-06 -TM7SF2 0.000447934141918511 -SPDYC 0.00185514874297755 -CDCA5 0.0707160812169158 -PPP2R5B 0.932458812261463 -C11orf85 0.00735718824902867 -ZNHIT2 0.200832999054726 -EHD1 0.894832021981373 -ZFPL1 0.654739309143482 -ATG2A 0.999922729645369 -GPHA2 2.06936557406623e-05 -NAALADL1 3.83011320553878e-12 -FAU 0.768145175266772 -SAC3D1 4.62359782878809e-05 -SNX15 0.000705751006111747 -ARL2 0.00739853976623839 -SYVN1 0.996650377830331 -VPS51 6.38019616804219e-05 -BATF2 0.0295318774859601 -MRPL49 0.0423029188906129 -FRMD8 0.0842909431231267 -SIPA1 0.0279051429893718 -CDC42EP2 0.150921493212549 -SLC25A45 7.20169689648338e-07 -RNASEH2C 0.511931591971642 -TIGD3 7.77840778267298e-11 -SCYL1 0.00778440657043786 -DPF2 0.999787288487276 -MAP3K11 0.170283101085365 -POLA2 0.000215959060480748 -LTBP3 0.996034358631329 -EHBP1L1 8.081316771713e-07 -KCNK7 6.42726120007493e-06 -RELA 0.998828467638028 -PCNXL3 0.488259801934332 -CAPN1 5.00439517393622e-05 -KAT5 0.471177718664719 -FAM89B 0.0291384645647437 -SSSCA1 0.00200151049783838 -CCDC85B 0.491379557770827 -FIBP 0.0147227845892947 -MUS81 1.5772598767523e-06 -CFL1 0.731049774850236 -CATSPER1 1.14276525299487e-08 -GAL3ST3 1.24668822518249e-06 -BANF1 0.739287243394207 -CTSW 2.6259020966295e-07 -EIF1AD 0.181571133840477 -EFEMP2 0.0283881635333074 -FOSL1 0.28979602655229 -OVOL1 0.676795693517501 -DRAP1 0.215306249804435 -AP5B1 6.97158289196506e-06 -SF3B2 0.999459845161211 -CST6 0.723124872712649 -C11orf68 0.409498865109943 -SNX32 2.72866806441788e-13 -SART1 0.992556330388662 -SLC29A2 1.32364671800173e-08 -RAB1B 0.751684324915879 -CTSF 1.32810650436187e-13 -CTD-3074O7.11 2.03206323452216e-07 -BRMS1 0.00107652477429526 -BBS1 1.77866932252961e-07 -NPAS4 0.424264241074538 -B3GNT1 0.159379726862654 -PACS1 0.999906351685189 -ZDHHC24 0.00614030824043694 -DPP3 4.36332090330589e-09 -MRPL11 2.04235979758032e-05 -CNIH2 0.894540206775537 -RIN1 0.000202046521763345 -RP11-867G23.8 0.114175280580478 -CD248 0.541815274554495 -KLC2 0.997255173219259 -TMEM151A 0.788175023378681 -PELI3 0.027343381963134 -YIF1A 2.08231700262511e-09 -RBM4B 0.442246701889638 -LRFN4 0.942092245046717 -ANKRD13D 0.984538263546097 -CCDC87 3.05913441954035e-06 -RBM4 0.943908956686511 -RHOD 0.203235060329607 -SYT12 1.02517315716305e-05 -C11orf80 0.00846259594390007 -SSH3 1.31856569258694e-07 -RBM14 0.987907650264068 -KDM2A 0.999999954603642 -RBM14-RBM4 0.918848169112948 -SPTBN2 0.999977956591075 -PC 0.716435670079512 -ADRBK1 0.998627979474698 -RCE1 0.559303286832047 -CCS 3.77236487706065e-06 -POLD4 0.745036468604439 -TBC1D10C 0.00160909822063443 -CARNS1 0.0221290003969173 -CLCF1 0.860488104474125 -NDUFV1 9.82538524288839e-05 -GSTP1 0.115024062658021 -CABP2 0.0212095370479509 -CABP4 1.84429317413404e-05 -C11orf72 0.00104922449953811 -NUDT8 0.0032881681662429 -CDK2AP2 0.25647477386357 -CORO1B 0.260249265031264 -TMEM134 3.02585174245466e-08 -GPR152 1.00978862123821e-05 -RAD9A 0.00232537793665103 -AIP 0.673915913889954 -PPP1CA 0.941508635503383 -RPS6KB2 3.2061006422526e-11 -PITPNM1 0.722090613819786 -TBX10 2.15116537729034e-07 -PTPRCAP 0.770195971803083 -TPCN2 2.06493806936103e-06 -GAL 0.000289003407059731 -LRP5 0.998355570314237 -MRPL21 5.45959674014109e-08 -MYEOV 0.00119290607835127 -UNC93B1 0.513837375928464 -C11orf24 0.0307663209865782 -MTL5 0.0332214023664625 -SUV420H1 0.999930189531327 -MRGPRF 0.370675550581141 -ACY3 1.8844549900242e-07 -CHKA 0.787088146901824 -ALDH3B2 0.000359298698542525 -CPT1A 0.9391397334386 -IGHMBP2 1.5094399423583e-08 -ALDH3B1 3.93511223222023e-05 -PPP6R3 0.995714713640604 -MRGPRD 0.000404522656857286 -NDUFS8 0.0141745022672731 -TCIRG1 6.03647247019708e-06 -CCND1 0.238186361767522 -FGF3 0.0330372169885067 -KRTAP5-8 0.006907479136412 -DHCR7 5.04266438763907e-08 -SHANK2 0.999920169615752 -KRTAP5-11 0.033567491593056 -CTTN 0.215776882831596 -ANO1 0.993084640132559 -NADSYN1 2.45472937261485e-09 -KRTAP5-7 0.581964460910534 -KRTAP5-9 0.000861770573554934 -FADD 0.665952895317945 -FGF4 0.750215677974647 -KRTAP5-10 0.191708884269112 -PPFIA1 0.999999874338716 -FGF19 0.294076907366963 -FAM86C1 1.47905868931909e-08 -AP000867.1 0.0289831629951808 -ORAOV1 0.0329902568453812 -P2RY6 4.63834764452777e-07 -PHOX2A 0.65257572600188 -P2RY2 0.0704719841364836 -FOLR1 0.00741067522640952 -PDE2A 0.988417592612146 -FOLR3 0.0108674399648362 -INPPL1 0.00608952548790821 -RNF121 0.972894709447048 -LRTOMT 0.0145642639198667 -IL18BP 3.32665579767765e-06 -NUMA1 0.999999245387494 -DEFB108B 0.0235485404628086 -FOLR2 6.16825536172656e-07 -FCHSD2 0.994752587131223 -ATG16L2 8.94242667912362e-09 -LAMTOR1 0.435675722554207 -ARAP1 1.50377669733894e-05 -ANAPC15 0.564413605348492 -STARD10 0.0510371457810707 -CLPB 9.1324224431567e-06 -CHRDL2 2.13642145685107e-05 -DNAJB13 0.121954826569755 -UCP2 1.91977015979194e-08 -ARHGEF17 0.995257098833384 -FAM168A 0.951667905445732 -KCNE3 0.444435272345118 -C2CD3 8.07884267817138e-10 -PGM2L1 0.390476072570689 -PPME1 0.92489377029294 -UCP3 1.07071142074629e-05 -MRPL48 0.138891984829277 -POLD3 0.99139424670152 -PLEKHB1 0.000703306678862264 -COA4 0.000586606150848862 -RAB6A 0.877760860434295 -PAAF1 1.03087812740244e-06 -RNF169 0.0841392817954343 -RELT 1.50780432907826e-05 -P4HA3 1.60495574125891e-07 -UVRAG 0.858602500357733 -WNT11 0.118580135382174 -GDPD5 0.0699851235479039 -DGAT2 7.51042690362332e-08 -OR2AT4 0.0460851530028238 -NEU3 1.64057530076216e-06 -KLHL35 1.35038973626761e-12 -MOGAT2 0.218649112879292 -C11orf30 0.999997096766169 -SERPINH1 0.16655084953195 -PRKRIR 0.968969189254267 -MAP6 0.0131669155399533 -RPS3 0.957385985784031 -ARRB1 0.986801821116486 -LRRC32 0.0215755256662984 -SPCS2 0.725113280909428 -SLCO2B1 0.00335356336964323 -XRRA1 4.2498222134866e-05 -MYO7A 5.37673856270135e-25 -USP35 0.0434784639735485 -GDPD4 9.33225882341034e-09 -B3GNT6 2.42261009335967e-06 -CAPN5 3.53957426282048e-07 -RSF1 0.999999962570394 -ALG8 1.00988304374679e-05 -TSKU 0.729712730834786 -THRSP 0.00560130986826702 -INTS4 0.653071264464616 -NDUFC2-KCTD14 0.626507873919539 -AQP11 0.0591720470749302 -CLNS1A 0.0950296158150142 -OMP 0.045566820595818 -PAK1 0.670970123358133 -KCTD21 0.29110859643231 -ACER3 0.831594948873275 -AAMDC 0.000474346768584031 -KCTD14 0.00289299266628188 -NDUFC2 0.625235914208963 -FAM181B 0.216567007712648 -CCDC83 6.83032869950337e-07 -TMEM126B 0.000531075640903117 -EED 0.997671033484958 -PRCP 3.33652772106359e-08 -SYTL2 2.11826952070561e-19 -CCDC89 0.00582182407300908 -PCF11 0.999999873982097 -RAB30 0.959123959685969 -CCDC90B 0.0090638207534691 -NARS2 0.000838255657065933 -PICALM 0.972083090436883 -CREBZF 0.0366616489719182 -ANKRD42 2.60039143890093e-08 -TMEM126A 0.00487417780484098 -DLG2 0.673545370161857 -C11orf82 5.25890335772558e-13 -GAB2 0.998921870889081 -TENM4 0.999718775956683 -TRIM49C 0.161108014215193 -NAALAD2 7.02449643708852e-15 -FZD4 0.920786850569231 -MTNR1B 0.00870272985599477 -CHORDC1 0.531116383359684 -C11orf73 0.769988210012451 -TYR 7.26380826960726e-21 -PRSS23 1.26863442289862e-06 -TRIM49 0.64552339591359 -CCDC81 2.78823114302232e-09 -NOX4 8.15748090375783e-07 -TMEM135 0.879933359061526 -RAB38 0.00471761819647518 -GRM5 0.985984068270878 -CTSC 0.000816868198136731 -ME3 1.1418824476976e-05 -FAT3 0.999999813687366 -ANKRD49 0.173264896104373 -CWC15 0.9002772115237 -PANX1 0.00309549630219255 -SMCO4 0.00205704974104072 -MRE11A 0.00115883260457516 -FOLR4 9.45254021176074e-09 -CCDC67 2.60445763225589e-11 -HEPHL1 7.16328140545691e-28 -GPR83 0.0324677129064709 -MED17 3.88512441026693e-06 -FUT4 0.055379992152633 -SLC36A4 2.69891717644805e-09 -KIAA1731 0.00287975572839384 -KDM4D 0.149201646842992 -TAF1D 0.00591146736086776 -PIWIL4 7.41292866543896e-06 -KDM4E 0.764772097616784 -C11orf54 0.00735855500344581 -AMOTL1 0.31122818605871 -CCDC82 1.73421696254218e-07 -CEP57 0.565432341176635 -C11orf70 8.92573228629031e-06 -TMEM133 0.025317130805039 -JRKL 0.000583510618527107 -CNTN5 0.00135406144303263 -MAML2 0.998525114326019 -BIRC3 0.886667092506474 -YAP1 0.998547799526509 -KIAA1377 6.77476563137896e-13 -MTMR2 0.212768599766799 -TRPC6 0.00456410505335574 -BIRC2 0.40445564763058 -SESN3 0.994296082928102 -ENDOD1 1.42162447825975e-06 -TMEM123 0.605287080500358 -FAM76B 0.0224491994808166 -PGR 0.884782623229294 -ANGPTL5 1.75089935363839e-11 -MMP10 1.98053112611486e-13 -DDI1 5.48151682948122e-06 -MMP7 1.6572045692897e-09 -CASP4 8.20826546130762e-07 -DCUN1D5 0.97199487015266 -CASP12 0.0877124851163816 -MMP13 2.16777707829054e-05 -MMP27 2.34681280025563e-10 -MMP8 1.17621282658989e-19 -CASP5 8.10674722109889e-09 -MMP1 2.48971498237184e-15 -CARD17 0.000301791817816637 -MMP20 1.62632042148573e-08 -CASP1 0.13679833104076 -PDGFD 0.0159483357606564 -MMP3 3.50440404382942e-08 -DYNC2H1 2.1785373082787e-21 -CARD16 0.0401643320693458 -SLC35F2 0.00952167661780261 -RAB39A 0.00185648965406038 -ALKBH8 0.00282934969265518 -ATM 2.71064232749178e-30 -KBTBD3 2.5976137143971e-05 -ELMOD1 0.536337679434055 -CWF19L2 9.64691491307459e-09 -AASDHPPT 0.0839417342934132 -CARD18 0.0487537469113847 -ACAT1 0.00159951559198285 -MSANTD4 0.00546195429080008 -EXPH5 5.76468072680194e-21 -C11orf65 8.78129550119407e-17 -AP000889.3 0.00767291884591441 -CUL5 0.999964792113235 -NPAT 0.14267656931501 -SLN 0.393191120931887 -GRIA4 0.988749209826684 -GUCY1A2 0.377257492585874 -KDELC2 1.57001885647098e-08 -FDXACB1 3.14671300310384e-07 -SIK2 0.99983680888605 -LAYN 2.17830732747888e-06 -ALG9 0.00122530850136209 -DDX10 5.41642779880176e-11 -PPP2R1B 2.18828630617287e-07 -C11orf1 7.80824715195598e-07 -COLCA1 0.0266155404570166 -ZC3H12C 0.998726025413791 -CRYAB 0.00909092009196377 -C11orf88 0.0986136578440954 -C11orf53 7.52888554833811e-05 -BTG4 0.256389240572353 -C11orf87 0.245098740734549 -FDX1 0.0839816283786201 -POU2AF1 0.752817874787067 -RDX 0.998954589256721 -ARHGAP20 0.00902004672136777 -HSPB2 0.211781189194987 -TIMM8B 0.226807933085792 -TTC12 1.44726952967987e-07 -C11orf57 0.913210185651405 -PTS 0.00115618802233995 -TMPRSS5 2.57785706102948e-08 -DLAT 6.67603193149511e-06 -ANKK1 2.51117065910348e-08 -DRD2 0.733263888671177 -IL18 0.102774109232244 -TEX12 0.133134681714709 -ZW10 0.0472628924555654 -C11orf52 0.0237243779473785 -PIH1D2 0.000130201269552391 -DIXDC1 4.26871314762917e-06 -BCO2 1.83157881067306e-13 -SDHD 0.70544004830206 -CLDN25 2.36412438667322e-09 -NXPE4 2.74741341116275e-08 -HTR3A 1.02839422335736e-09 -HTR3B 6.14952696572758e-07 -C11orf71 0.00842481501256066 -NXPE1 3.48609216284613e-10 -NNMT 0.00427916395502723 -BUD13 0.00229542848916745 -REXO2 0.888428672321779 -APOA4 3.57595118139907e-05 -APOC3 0.00067802640410586 -ZBTB16 0.980087305825708 -RBM7 0.769935289328386 -USP28 0.031657505195455 -CADM1 0.99438640410443 -APOA5 1.37735073361006e-06 -PAFAH1B2 0.962029472445706 -NXPE2 0.244911849376349 -SIK3 0.999882540750175 -ZNF259 0.0193034953229086 -APOA1 0.0487383759438174 -SIDT2 0.00257240105871232 -AMICA1 0.0040590935326328 -SCN2B 0.133477243490071 -TMPRSS13 6.08622571727962e-05 -TAGLN 0.241537680178233 -CEP164 9.66879225304467e-18 -MPZL3 6.52170419480443e-09 -TMPRSS4 1.19754386539244e-08 -SCN4B 0.00153522738620452 -FXYD6-FXYD2 0.637758562604967 -CD3E 0.302672925327359 -FXYD2 0.698943754498667 -PCSK7 0.191369613352617 -RNF214 0.830018244677536 -CD3D 0.00662794601075922 -FXYD6 0.829814383552752 -MPZL2 1.21919862877634e-11 -BACE1 0.944278809144277 -DSCAML1 0.999999092176902 -IL10RA 0.968345855815418 -ARCN1 0.999850871289472 -TRAPPC4 0.0013236960271552 -TREH 1.40028647894894e-14 -CD3G 0.0250305279644512 -ATP5L 0.337891181698725 -DDX6 0.998985995919041 -UPK2 2.80119065022381e-06 -KMT2A 1 -BCL9L 0.998124598837792 -CXCR5 0.16025378973425 -PHLDB1 0.81858015218857 -RPS25 0.809686936073412 -FOXR1 0.00292657754004723 -CCDC84 4.70436509120475e-06 -TTC36 0.507038897896992 -TMEM25 0.00042136891544107 -IFT46 0.950870755108113 -UBE4A 0.937619432134248 -RP11-770J1.5 0.0139344190138334 -HYOU1 0.9997793595111 -NLRX1 9.83505664629216e-22 -CCDC153 0.154452992851167 -HMBS 0.944813615556974 -SLC37A4 0.000674732363421853 -USP2 0.185180861868735 -C1QTNF5 0.830646789327775 -MFRP 5.34353005764772e-08 -THY1 0.164135342066625 -DPAGT1 0.00018751828847891 -ABCG4 0.000455417358401195 -H2AFX 0.620410500240712 -VPS11 0.223659481916243 -HINFP 0.979628977326725 -C2CD2L 0.998151740074915 -RNF26 0.677950757165205 -MCAM 0.0547531292437873 -PDZD3 3.35725944256501e-07 -CBL 0.00678735718516732 -PVRL1 0.503155896301941 -GRAMD1B 0.984850768297199 -HSPA8 0.997882601177929 -CLMP 3.02178689371524e-05 -CRTAM 1.15272875885834e-06 -BLID 0.590165692367457 -ARHGEF12 0.99999892582633 -SC5D 0.103132834566042 -TECTA 1.06498565113514e-12 -TMEM136 0.0348719238573205 -OAF 0.00616888335875156 -UBASH3B 0.988510645026986 -SORL1 0.0174141233573499 -POU2F3 0.00288839549557629 -TBCEL 0.971498208896393 -TRIM29 9.16729542241399e-05 -GRIK4 0.630846158157366 -C11orf63 1.16452328608552e-11 -BSX 0.136321314394079 -OR8G1 0.285950158784041 -SCN3B 0.347297034219147 -OR6X1 0.00034659635921149 -OR8G5 0.652742658849299 -OR10G4 0.216924072224088 -VWA5A 1.88623682085499e-15 -OR10G9 0.00713845173418904 -OR10G8 0.636591633450699 -OR10G7 0.00712210899720655 -OR8D4 0.0504863379478631 -OR8D2 0.616576837370082 -ZNF202 0.138743297874791 -TMEM225 0.541094557388445 -OR6M1 0.00196364804612078 -OR6T1 7.96194444184611e-05 -OR4D5 0.00186757114304027 -OR10S1 0.00188929864169299 -OR8D1 0.215921298613233 -HEPN1 0.0262294918736351 -ROBO3 0.0286120107539813 -NRGN 0.536942023282865 -ESAM 0.191978713582815 -HEPACAM 0.630644860946896 -VSIG2 0.000163565811379291 -ROBO4 1.66866223576903e-09 -CCDC15 3.21210263109898e-16 -OR8B4 0.707743835067628 -TBRG1 8.02614053558845e-05 -OR8B12 0.178075255695636 -OR8B8 0.00555520538174593 -OR8B3 0.618283247505984 -OR8A1 0.058828646142404 -OR8B2 0.205712840071851 -SIAE 2.58571955397209e-09 -RP11-664I21.6 0.0970957801810817 -MSANTD2 0.70997170666646 -PANX3 0.00188124156678788 -SPA17 0.00626347389447245 -SRPR 0.992611253840392 -TMEM218 0.00149018994146523 -RPUSD4 0.00672913845111168 -PKNOX2 0.91736894679552 -FEZ1 0.540112166448388 -HYLS1 5.8228427856488e-05 -CDON 3.04906879944482e-12 -CHEK1 0.000249110252826237 -PUS3 1.0865601617407e-05 -FAM118B 0.390427138904487 -ACRV1 0.00043284285276665 -PATE1 7.59081522526465e-08 -STT3A 0.978952343158655 -DDX25 4.23433637836541e-09 -SLC37A2 5.00926399593573e-10 -EI24 0.965168318705079 -PATE2 3.37327473997107e-05 -KCNJ5 0.309232169469227 -TP53AIP1 9.46747721512866e-07 -ST14 0.85267655285458 -PRDM10 0.998059991340664 -TMEM45B 8.86544079040378e-07 -APLP2 0.521618002879557 -TIRAP 0.00266923121316854 -FLI1 0.819814084378667 -ST3GAL4 0.439048570873843 -ETS1 0.795176655680943 -ARHGAP32 0.987088519508478 -DCPS 0.00163802399731831 -KIRREL3 0.977505780991965 -FOXRED1 4.09171835158384e-11 -RP11-712L6.5 0.402528095080464 -KCNJ1 0.001702478576957 -BARX2 0.123464487684471 -C11orf45 0.0137112878913203 -ZBTB44 0.992064123809693 -NFRKB 0.752744578187088 -NCAPD3 0.0731520869970458 -VPS26B 0.970719437677481 -GLB1L2 1.44692099840466e-16 -ADAMTS8 1.0556522196896e-08 -ACAD8 1.16610074814559e-05 -SNX19 9.83338246488835e-07 -THYN1 1.40363665599038e-09 -IGSF9B 0.99987339409272 -NTM 0.525365693930018 -OPCML 0.578155981232135 -B3GAT1 0.78915280663019 -JAM3 0.000178704009379398 -ADAMTS15 0.679914358287786 -SPATA19 5.976953927201e-05 -GLB1L3 1.88655110815495e-13 -WNT5B 0.835340308837053 -IQSEC3 0.925104239220891 -DCP1B 5.3210820854203e-07 -WNK1 0.999999999364508 -ADIPOR2 0.810597984007902 -CACNA1C 0.99999843310185 -FKBP4 0.927473130653813 -SLC6A13 1.85726644531532e-08 -ERC1 0.00412388322590132 -RAD52 2.38441629175774e-07 -FBXL14 0.40527008579802 -CCDC77 9.40308683942061e-15 -LRTM2 0.739704570731645 -SLC6A12 7.90050068276314e-07 -B4GALNT3 1.06179854846531e-07 -KDM5A 0.999994827471308 -CACNA2D4 4.57168482146793e-22 -NINJ2 0.0201388621613476 -NRIP2 9.12047384069789e-08 -ITFG2 1.38956896751476e-06 -EFCAB4B 0.00382179118476076 -CCND2 0.949000818432094 -TULP3 0.00103688890759594 -PARP11 0.00015946555998602 -FOXM1 0.802589769159313 -AKAP3 0.0263329788992228 -KCNA6 0.961132595185659 -FGF23 0.0279896645640281 -RAD51AP1 0.0223532839828689 -GALNT8 1.87452420046286e-10 -KCNA5 0.000687391815094003 -NDUFA9 0.542744183961533 -C12orf5 0.691296680522057 -DYRK4 3.79608758155986e-10 -KCNA1 0.0518014558510951 -FGF6 0.000705757813368273 -RHNO1 0.000558184641145266 -PRMT8 0.95875274427484 -C12orf4 9.82515157241538e-05 -TSPAN9 0.779777700780573 -IFFO1 0.0207323486767856 -VAMP1 0.673786666046467 -MRPL51 0.0667471984789823 -TAPBPL 3.2851378423028e-07 -ANO2 2.8480469622138e-18 -TNFRSF1A 0.985476047130114 -LPAR5 0.0296429210794608 -PLEKHG6 1.17026398871661e-10 -GAPDH 0.180460004147139 -CHD4 0.999999998385354 -NTF3 0.854440385007675 -CD9 0.147688594875406 -VWF 1.52411378256046e-11 -LTBR 0.428683150276069 -ACRBP 1.88089650899479e-07 -SCNN1A 9.40050560868697e-06 -NCAPD2 5.92581370196276e-08 -ING4 0.0521019243914109 -NOP2 0.0489276422808689 -CD27 0.266793352840931 -GNB3 6.50125510048293e-09 -USP5 0.996309624736257 -ZNF384 0.941996440237097 -SPSB2 0.125059417279287 -C12orf57 0.0603360644826819 -MLF2 0.921484672213679 -GPR162 0.0171343880053493 -PTMS 0.778967638261344 -ATN1 0.998533107154739 -CD4 0.00150688725929523 -LRRC23 0.000915908771944211 -LEPREL2 3.19759536270092e-08 -PIANP 0.619509239955918 -TPI1 0.581366832186706 -PTPN6 0.999911914896819 -COPS7A 0.922072581433795 -CDCA3 0.913578465420915 -ENO2 0.0185777100017329 -LAG3 0.109617010744363 -PHB2 0.0758353620381498 -SLC2A14 0.989967414117294 -RBP5 0.00181920990078845 -C1S 0.863410048494588 -APOBEC1 0.000144861579102738 -CLEC4C 0.000999349230166641 -GDF3 0.0812132152427739 -CLSTN3 0.997857932255683 -PEX5 0.401174868136947 -LPCAT3 0.980678848782637 -EMG1 0.0106038960648901 -CD163L1 2.21693679765122e-17 -C1RL 0.000277416754917204 -ACSM4 4.67032830619752e-11 -CD163 0.0151369036126436 -DPPA3 0.165194336334944 -FOXJ2 0.998394611630928 -C3AR1 4.69335718249232e-05 -NANOG 0.911618852133588 -SLC2A3 0.519822945853932 -AICDA 0.00125550164168763 -CLEC4E 0.00355802800557527 -CD69 0.0188833577598224 -A2ML1 1.32902210264609e-22 -A2M 0.000540114865271392 -CLEC6A 1.79122751588445e-06 -PHC1 0.997152365464677 -FAM90A1 6.49112967670201e-12 -ZNF705A 0.0524783696043198 -M6PR 0.71302578173056 -PZP 1.35183771709263e-21 -CLEC4A 7.43752503067102e-07 -CLEC2D 0.767944822366651 -NECAP1 0.0409114385552469 -CLEC4D 0.000109415250448658 -MFAP5 0.348683723133855 -KLRG1 0.0580256114184196 -CLECL1 1.65162875088135e-06 -RIMKLB 0.911252633654497 -KLRB1 4.43124831904582e-06 -CLEC1A 2.08332477642767e-10 -GABARAPL1 0.782335274522732 -KLRD1 0.015657762831995 -CLEC12B 0.000124715849356653 -CLEC12A 6.28346136908363e-06 -CLEC7A 7.98974757902589e-08 -NKG2-E 0.0181894806690389 -KLRC1 0.00117546106046322 -CLEC1B 0.00010417075731215 -CLEC9A 2.45378474312192e-05 -KLRC4 0.00108734943903597 -KLRF1 0.00436476048223472 -KLRC2 0.00427823231663552 -CLEC2B 0.00273195547397739 -KLRC3 0.204478935607772 -KLRK1 9.74878780699033e-10 -TMEM52B 0.0401804982967945 -OLR1 0.297321524092708 -TAS2R20 0.00447601535837195 -TAS2R19 0.00414619841164368 -TAS2R10 0.428565950557266 -MAGOHB 0.0417829970477984 -TAS2R8 0.0124682631133943 -TAS2R7 0.0230774509333994 -EIF2S3L 0.147907104544137 -PRR4 1.03390158107127e-05 -YBX3 0.00662806716120506 -PRH2 0.595625943201393 -TAS2R9 0.000278743191968872 -TAS2R14 0.00105542818770112 -TAS2R46 3.10044300046628e-08 -PRH1 0.284195071358163 -STYK1 1.53641100905639e-05 -TAS2R31 2.54372259099135e-05 -TAS2R13 0.579968726680784 -TAS2R43 0.00210427361078187 -TAS2R50 1.89175446267053e-07 -PRB4 8.85269506815037e-08 -LOH12CR1 0.021632084531083 -GPRC5A 8.02764467699413e-06 -TAS2R42 0.0025809974952036 -MANSC1 0.000352735755361128 -DUSP16 0.112697836437734 -HEBP1 8.07251624878692e-05 -GPR19 0.348589813892755 -PRB3 2.57026606514489e-07 -CREBL2 0.623023671533736 -BCL2L14 0.14312358632999 -APOLD1 0.000507905443363466 -LRP6 0.999978329943341 -CDKN1B 0.847005306213341 -TAS2R30 0.00170314797923996 -PRB2 2.87656217860537e-14 -GPRC5D 2.97022164147864e-05 -ETV6 0.99522782011263 -DDX47 1.14178044496829e-08 -PRB1 2.09216771553037e-05 -C12orf36 0.00537404588595086 -HIST4H4 0.260791362702686 -KIAA1467 0.221017048145421 -ART4 0.00145180854137921 -ERP27 1.10529479333454e-07 -C12orf60 0.00629216814365261 -SMCO3 0.205394525245437 -RERG 0.00116495678097805 -ARHGDIB 0.000280473501044255 -H2AFJ 0.765927441730416 -PLBD1 9.67351257348209e-13 -ATF7IP 0.99974103814101 -MGP 0.00672833394383241 -GRIN2B 0.999994895762786 -EMP1 0.411003665812915 -PDE6H 0.00652871284753312 -GUCY2C 1.77521150622888e-18 -GSG1 0.00134933358137472 -WBP11 0.999928146457789 -PTPRO 0.304626089545522 -CAPZA3 0.000212651606249841 -LMO3 0.43420908358226 -PLCZ1 6.45114192499903e-10 -DERA 0.0340764800521968 -SLCO1B7 4.9248493708995e-17 -IAPP 0.166030146477273 -SLCO1A2 5.58441209241734e-15 -SLCO1B1 3.45238778980654e-16 -STRAP 0.701829615941537 -PLEKHA5 0.999999407945124 -PDE3A 0.106612095996096 -RERGL 5.31614636600088e-09 -SLCO1B3 9.24108066211779e-17 -PIK3C2G 9.18857248003686e-32 -SLCO1C1 7.6167599235895e-06 -EPS8 0.947393284119214 -AEBP2 0.950982695744305 -MGST1 0.0140289444910937 -LST3 2.45570570280504e-17 -BCAT1 7.04875662949652e-06 -C12orf77 0.00286773857994041 -CMAS 0.472364310654414 -LYRM5 0.00088717027424368 -ETNK1 0.865130479359824 -SOX5 0.999398884487612 -KCNJ8 0.256769967780786 -LRMP 0.0209127073492332 -KRAS 0.00106119304255182 -C12orf39 0.005505192002489 -LDHB 2.02750017037306e-05 -C2CD5 8.69478577467222e-07 -CASC1 8.0583173448997e-12 -ST8SIA1 0.211574643725732 -PYROXD1 3.50579116851114e-07 -GYS2 1.21631815172674e-14 -RECQL 7.14017324493182e-13 -GOLT1B 0.798383719617006 -ABCC9 0.000700542902364641 -IFLTD1 2.39046582778289e-09 -ITPR2 5.7359279512263e-11 -STK38L 0.965893632010774 -C12orf71 0.360330750091633 -TM7SF3 0.0898995981071209 -RASSF8 0.841236340481478 -SSPN 0.753322775232488 -PPFIBP1 2.09888083812757e-12 -MED21 0.0580450998864159 -CCDC91 3.15157303302004e-05 -FGFR1OP2 0.42972800313106 -REP15 0.00139895184971886 -MRPS35 0.0409282753572301 -ASUN 0.998587603501794 -PTHLH 0.921296517827875 -ARNTL2 2.37204609554434e-06 -KLHL42 0.438781823689429 -DNM1L 0.176947821562628 -ERGIC2 0.320357206097489 -AMN1 0.0201026561840101 -TMTC1 3.06491591423056e-07 -FAM60A 0.936959839782085 -METTL20 5.20322751250045e-05 -CAPRIN2 0.0120891274382742 -DENND5B 0.999945504401691 -YARS2 6.88418442329642e-06 -FGD4 0.335778541836355 -BICD1 0.144785241366813 -H3F3C 0.297369301956225 -FAR2 0.922173887824306 -TSPAN11 2.9598251783614e-05 -OVCH1 1.53112390015935e-28 -KIAA1551 0.0364911089052999 -IPO8 0.97978380275245 -PDZRN4 0.0708527732027404 -LRRK2 7.5565041633134e-14 -KIF21A 6.18012815847982e-05 -PKP2 6.1431013754488e-10 -C12orf40 1.15273949503851e-19 -ZCRB1 0.000953935727738575 -SLC2A13 0.956100908800451 -PUS7L 1.56980935543342e-06 -CNTN1 0.999989199613199 -ADAMTS20 4.85371907276584e-26 -ALG10B 0.000152772162093977 -ALG10 0.00574913500300478 -PPHLN1 7.58102542315877e-05 -GXYLT1 0.987483160840119 -CPNE8 0.07800427323508 -SYT10 0.123246845459562 -YAF2 0.842513636178487 -PRICKLE1 0.991966858696436 -ABCD2 2.96980747420595e-06 -SLC38A2 0.969356999809796 -AC004466.1 0.000546041514682032 -ENDOU 6.22319085378802e-12 -SLC48A1 0.437511991431989 -SLC38A1 0.975432122735683 -TMEM117 3.5741678559228e-05 -IRAK4 0.00057687169808497 -DBX2 4.41842154586426e-08 -RPAP3 0.140309540099749 -ARID2 0.999999053128101 -ANO6 4.52445486156544e-20 -SCAF11 0.999681330779109 -AMIGO2 0.545241647080824 -NELL2 0.999853571748522 -VDR 0.392125211518415 -TWF1 0.00796369297166301 -HDAC7 0.998019873410435 -SLC38A4 0.942982185779924 -RAPGEF3 2.0974108088557e-15 -PCED1B 0.00826612737821006 -LALBA 0.395945445252935 -ADCY6 0.596680215378215 -H1FNT 0.00506623310388001 -KANSL2 0.404028496542896 -ASB8 0.0180285302816205 -PFKM 6.03263003776653e-07 -ZNF641 0.228415943182732 -TMEM106C 3.96020841080124e-06 -OR10AD1 0.00351676157654617 -C12orf68 0.62547082649676 -CCNT1 0.995809373034455 -OR8S1 3.08155201788778e-06 -C12orf54 0.00416735395983964 -SENP1 0.99389690234868 -ANP32D 0.147937099023862 -COL2A1 0.999999986012304 -DHH 0.259714235022627 -TUBA1C 0.840150770014777 -TUBA1B 0.828418234696983 -DDN 0.986679783745218 -TROAP 3.02009096735006e-07 -CCDC65 9.59689476863394e-07 -DDX23 0.999558303316101 -RHEBL1 3.29298900292704e-06 -ARF3 0.622731323606937 -RND1 0.965631677734805 -FKBP11 2.22757446059631e-05 -LMBR1L 2.18323454000279e-06 -PRPH 5.04583995510316e-10 -CACNB3 0.0495836525739543 -WNT1 0.101878962320727 -TUBA1A 0.836535571093595 -PRKAG1 0.00163708742661498 -WNT10B 0.00399812606925071 -KMT2D 0.999999999999995 -RP11-302B13.5 0.63027046059773 -PRPF40B 0.98865339397477 -NCKAP5L 0.56561925191278 -RACGAP1 0.786373400640943 -AQP6 0.211427984634698 -FAM186B 2.40022432048492e-12 -MCRS1 0.0665356264871206 -TMBIM6 0.0161697441134311 -FAIM2 0.619353001444294 -SPATS2 0.989651259812943 -BCDIN3D 0.00503914777207975 -AQP5 0.00438548410684657 -C1QL4 0.621177258193781 -SMARCD1 0.99952730034881 -COX14 0.193248416761832 -GPD1 0.147319093451793 -AQP2 4.17696058293906e-06 -DNAJC22 1.10777165570409e-05 -ASIC1 0.988325492354336 -KCNH3 0.999889995234816 -FMNL3 0.356499503624211 -GALNT6 1.65843390047223e-06 -LETMD1 0.793860582161175 -POU6F1 0.907559367268063 -DAZAP2 0.527543739723783 -LARP4 0.994628855689498 -BIN2 0.000209938130106231 -ATF1 0.663831053655397 -CERS5 1.31067685318133e-05 -TFCP2 0.000102418586669595 -SMAGP 0.0451746107003794 -METTL7A 0.00551876494694803 -SLC11A2 0.00623523691810572 -HIGD1C 2.42000601499889e-05 -TMPRSS12 0.00311627484097927 -CSRNP2 0.950516343514854 -CELA1 0.129951931571659 -DIP2B 0.999668381879693 -LIMA1 1.28359617495965e-07 -SLC4A8 0.999867374132928 -KRT75 5.13559935197705e-07 -KRT81 2.1584354437647e-07 -KRT82 2.61197625522827e-16 -KRT85 0.00110914581875823 -ACVRL1 0.00794107205683194 -KRT6C 4.10516812763235e-12 -KRT6B 0.00479265544310742 -C12orf44 0.731720304904651 -KRT86 3.63965280007909e-05 -ACVR1B 0.998904331171601 -KRT80 5.43098446060312e-05 -KRT6A 0.948763036418681 -KRT83 1.70400143344448e-10 -KRT7 2.78644976230631e-09 -ANKRD33 1.96179306102665e-14 -NR4A1 0.959497620910649 -SCN8A 0.999998290292746 -KRT84 9.43275724197859e-07 -GRASP 0.930936502160189 -KRT73 2.00824929501873e-11 -KRT1 0.973618209444121 -KRT3 1.92686672080473e-06 -KRT78 2.05638911162984e-08 -KRT76 6.27273672835566e-07 -KRT8 5.61440512780514e-06 -EIF4B 0.99998652408939 -KRT18 0.62478258844471 -KRT79 2.9864941695015e-10 -KRT2 0.0673499186894365 -IGFBP6 0.0923313370768109 -KRT5 0.469327657850036 -KRT77 1.05294123025074e-06 -KRT71 3.12740120353346e-08 -SPRYD3 0.94694247848355 -TENC1 0.000160117108171403 -KRT72 3.06920505425378e-05 -SOAT2 9.10116639624956e-18 -KRT4 0.000566042966242136 -KRT74 8.39640673732565e-09 -RARG 0.970063074313349 -PRR13 0.634332002252778 -CSAD 2.4796775415935e-06 -AMHR2 5.93082108191015e-07 -NPFF 0.000253702225634586 -C12orf10 2.43605474737215e-06 -TARBP2 0.446803723604583 -RP11-793H13.10 0.480886450381891 -ATF7 0.983314715299326 -MFSD5 0.102466254658811 -ITGB7 0.00265423920172315 -SP7 0.663143306771365 -MAP3K12 0.99998181311032 -PFDN5 0.0433855614772836 -ATP5G2 0.000275239005290865 -SP1 0.997637149483068 -AAAS 4.54287182926272e-10 -ESPL1 0.999999917627418 -ZNF740 0.653748287756941 -PCBP2 0.987030330209409 -CALCOCO1 0.171891880753814 -GPR84 2.72207266045491e-07 -SMUG1 0.00123008785180229 -HOXC12 1.8910234355918e-09 -ITGA5 0.999798063012463 -NCKAP1L 0.990439663587777 -HOXC4 0.311491215792623 -HOXC13 0.379358816453153 -HOXC9 0.128099662221138 -HOXC10 0.648346217700278 -HOXC5 0.039073775712826 -HNRNPA1 0.966614388412206 -GTSF1 0.513379498300112 -NFE2 0.688914373837473 -ZNF385A 0.848554693733189 -HOXC11 0.0786952810694774 -CBX5 0.835000939076987 -COPZ1 0.890701152776699 -HOXC8 0.392360835996751 -HOXC6 0.907689925205709 -LACRT 8.87854549242137e-05 -PPP1R1A 0.00857614104493053 -TESPA1 1.91516352804028e-05 -OR9K2 9.7525214366511e-05 -PDE1B 0.94673728390002 -OR6C76 0.00102177135806382 -DCD 0.00361067086160127 -OR6C4 1.10236491400675e-07 -OR6C74 0.0780086954370734 -OR6C75 0.0484775642216433 -OR6C1 0.0123858709297222 -OR6C70 1.41010421459543e-05 -OR6C3 0.000123119568975691 -OR10A7 0.268100024278158 -OR6C6 0.0658375506091577 -OR6C2 0.658293420139718 -OR6C65 0.00106148732110602 -MUCL1 1.14812282999876e-05 -NEUROD4 0.140552618676384 -OR6C68 0.000123416793775027 -OR2AP1 0.00290394574305701 -RP11-644F5.10 0.0386103160865983 -PMEL 1.12363431292712e-07 -SARNP 0.989074046382946 -DGKA 0.999250949298834 -WIBG 0.862135667337759 -CDK2 0.958299189494179 -SUOX 0.00208476865750542 -RDH5 3.1134515694943e-06 -BLOC1S1 0.205801576114329 -ORMDL2 0.15086877829343 -RAB5B 0.215698853711726 -METTL7B 0.522330681005523 -ITGA7 1.80979797287063e-09 -OR10P1 0.0192350794042469 -IKZF4 0.953608121096321 -MMP19 1.45383844369831e-13 -DNAJC14 0.999707754511218 -CD63 0.00716077580833122 -GDF11 0.963838119160384 -STAT2 0.0410947373611941 -NABP2 0.956804648100521 -ESYT1 2.14071709405869e-07 -ERBB3 4.35825057327711e-06 -RPS26 0.753342825086325 -PA2G4 0.998000990941836 -SMARCC2 0.999999989058527 -IL23A 0.842438306418319 -APOF 0.0193380084394216 -MYL6B 0.00373381128610738 -ZC3H10 0.792020464408796 -CS 0.999828375740044 -PAN2 0.946674806799818 -RPL41 0.0415295991097929 -MYL6 0.256616370152787 -SLC39A5 1.20741073816294e-07 -CNPY2 0.0300953472407302 -COQ10A 0.12109648380279 -RNF41 0.856083577085887 -ANKRD52 0.999987966825373 -RBMS2 0.00291479790209536 -NACA 0.0203382171134431 -ATP5B 0.991635070003861 -TMEM194A 0.0290896643526579 -BAZ2A 0.999999725956371 -NAB2 0.987535197753901 -HSD17B6 0.381986470871383 -PRIM1 0.0268979390191366 -SPRYD4 0.000589211754630036 -PTGES3 0.871365849855667 -TAC3 0.040450004755837 -MIP 0.677914765017758 -MYO1A 1.94521735757924e-35 -TIMELESS 1.03547195051349e-25 -GPR182 0.000859696118417304 -SDR9C7 0.013528777168157 -RDH16 8.59884923667545e-05 -GLS2 0.0009871223239844 -ZBTB39 0.00973093010397182 -NDUFA4L2 0.0142523749586636 -STAC3 0.00487830161425738 -GLI1 1.94829927539368e-06 -DDIT3 0.515502016999664 -KIF5A 0.999979703146806 -DCTN2 0.996367311488722 -MARS 2.73685367110748e-12 -LRP1 1 -ARHGAP9 2.89131295292005e-09 -DTX3 0.921137255195518 -SHMT2 0.00748753462073037 -PIP4K2C 0.0133787346006026 -MBD6 0.963657500420421 -ARHGEF25 5.17606707704438e-06 -STAT6 0.100774662146281 -INHBC 0.083686116557619 -NXPH4 0.462095793940255 -INHBE 7.68032635379316e-06 -R3HDM2 0.995928589389731 -LRIG3 0.426287752609207 -B4GALNT1 0.0560737731652395 -CDK4 0.93201691552067 -OS9 1.13151214875817e-07 -METTL21B 0.00509293953556655 -XRCC6BP1 0.00463367011739199 -CYP27B1 3.60155144475408e-06 -AGAP2-AS1 0.0423449093257325 -AGAP2 0.999218902067889 -SLC26A10 1.16500286588742e-09 -AVIL 1.03036255351714e-10 -METTL1 0.0059156174332639 -TSPAN31 0.32725853041475 -MARCH9 0.350280135696905 -FAM19A2 0.547457170346071 -SLC16A7 0.00178576628878128 -CTDSP2 0.397665011331897 -TSFM 9.80455460336749e-08 -DPY19L2 7.02940400276182e-05 -LEMD3 0.998968434807237 -XPOT 0.997933923133681 -RASSF3 0.00159786199358572 -TMEM5 1.85422958050936e-06 -WIF1 2.41723210239144e-05 -MON2 0.982708262602224 -USP15 0.990365016125739 -TBK1 0.995096971403116 -C12orf56 2.90933463847163e-11 -GNS 0.0829052963160252 -MSRB3 0.00702679578516966 -C12orf61 0.0545281957159483 -PPM1H 0.855024040523664 -SRGAP1 0.987851405418528 -AVPR1A 1.28646095006851e-05 -C12orf66 0.757788499527866 -HMGA2 0.733852103838821 -MDM1 5.78287888907171e-08 -LYZ 0.00137551693250335 -DYRK2 0.979337328880354 -GRIP1 0.916894968096624 -SLC35E3 0.00040677888074501 -RAP1B 0.936825076137946 -CPM 8.0712082035317e-07 -MDM2 0.995410847609102 -LLPH 0.341447375249415 -NUP107 1.19844636512887e-06 -IL26 0.0527617615393175 -TMBIM4 0.0020799620820819 -IRAK3 3.58183663944626e-15 -YEATS4 0.0987387891578807 -IL22 0.490718395700443 -CPSF6 0.999113680151761 -CAND1 0.999927001146307 -IFNG 0.0204465656775392 -HELB 2.01687819135373e-13 -CCT2 0.999501007213571 -TSPAN8 0.0086947214274004 -FRS2 0.979070203401274 -TMEM19 0.0013806937133801 -TPH2 0.696911876254858 -KCNMB4 0.829402296381292 -PTPRB 0.943502941208234 -ZFC3H1 0.999999999616417 -RAB21 0.882341696062871 -CNOT2 0.999868597154773 -RAB3IP 0.0167529426994785 -THAP2 5.16530633847092e-05 -BEST3 3.69441601591338e-17 -TRHDE 0.0809965086232841 -LRRC10 0.00919176631881308 -PTPRR 0.000430475916164989 -LGR5 1.13571270342706e-05 -TBC1D15 0.148718808827344 -GLIPR1L1 0.00366338494663925 -ZDHHC17 0.998394623926362 -PPP1R12A 0.999179084030694 -KRR1 0.0193505805705808 -SYT1 0.837180354589946 -ATXN7L3B 0.0979606124442928 -E2F7 0.423130675694931 -GLIPR1 1.05178857542352e-09 -BBS10 6.78247357873408e-09 -KCNC2 0.00359681821930559 -CSRP2 0.000305231930183442 -NAP1L1 0.993880985311057 -GLIPR1L2 0.00310862434597101 -OSBPL8 0.988348145917672 -PHLDA1 0.166867882714649 -OTOGL 3.7282457621613e-31 -NAV3 0.999999398861806 -CAPS2 2.65069655043534e-09 -PAWR 0.442459924660124 -MGAT4C 0.0111690534801191 -ALX1 0.600326160302233 -C12orf50 0.000154448367602554 -METTL25 1.64825272550087e-07 -PPFIA2 0.999975971595094 -SLC6A15 0.00226259561522053 -TMTC2 0.863100805982337 -CCDC59 0.000680494758463173 -LRRIQ1 6.84986559676448e-19 -CEP290 1.03912081117924e-34 -TSPAN19 2.63765238175314e-09 -ACSS3 2.99940752851555e-11 -C12orf29 2.45710284617945e-05 -TMTC3 0.00905213224625117 -KITLG 0.508530401642626 -RASSF9 7.70404622377727e-05 -NTS 7.97101367921064e-06 -LIN7A 0.0411484963561707 -MYF5 0.0019034048050669 -MYF6 0.0762860430466965 -PLEKHG7 3.6750124896981e-11 -LUM 0.101924740774409 -DUSP6 0.911205141065287 -KERA 0.000414369553245371 -CLLU1OS 0.0527318795262529 -DCN 0.457565652637867 -CCER1 4.84730770012203e-07 -MRPL42 0.0278815666313714 -POC1B-GALNT4 0.0375964932909429 -POC1B 5.89427992774507e-05 -C12orf74 0.000522237109268262 -ATP2B1 0.999997542188065 -UBE2N 0.787720767545003 -GALNT4 0.112929757253281 -EPYC 5.0529732963996e-05 -NUDT4 0.164174989201243 -EEA1 0.6973588149443 -CLLU1 0.0413682841967756 -BTG1 0.483157589180579 -HAL 5.90868534733458e-17 -TMCC3 0.000392184014749242 -PLXNC1 0.999714839774068 -NR2C1 0.98233319709664 -LTA4H 0.0494218192368297 -CRADD 0.731812881349657 -FGD6 0.995227689206774 -CCDC41 8.74184019994934e-09 -USP44 1.46115265759899e-09 -SOCS2 0.0985304077058318 -CCDC38 1.56677307281946e-08 -NTN4 0.994426784918463 -METAP2 0.906382727005543 -SNRPF 0.734661647651888 -AMDHD1 2.46953918892759e-06 -RP11-1105G2.3 0.337743806668859 -ELK3 0.101741246004499 -VEZT 0.0259368505876322 -NDUFA12 0.00201599261273099 -ACTR6 0.00468594297720818 -UHRF1BP1L 0.989377600602275 -ANO4 0.844044636742629 -APAF1 3.82072122629714e-05 -TMPO 0.000659535706594771 -C12orf55 9.30036258919147e-13 -SLC17A8 0.0449262500512103 -GAS2L3 0.000258593475911662 -FAM71C 0.0299979974622026 -UTP20 0.170231062921548 -NEDD1 0.221564198564528 -SLC25A3 0.0715576488202016 -ANKS1B 0.992771667778122 -SCYL2 0.931828671048131 -DEPDC4 4.10418498875559e-09 -NR1H4 0.161696750786205 -SLC5A8 2.85808956199266e-11 -CDK17 0.988843485373774 -IKBIP 9.59326123111629e-05 -HSP90B1 0.987843128807057 -PMCH 0.115285755884675 -SPIC 0.118412347531258 -STAB2 4.17567584164662e-28 -C12orf42 2.29275590874033e-07 -CHPT1 0.0035704767848813 -PARPBP 9.66662310636925e-13 -NT5DC3 0.000112402109573626 -ASCL1 0.364739460004734 -GNPTAB 4.22557947344879e-06 -IGF1 0.469523496452965 -CCDC53 0.0351259294423371 -MYBPC1 0.657926418342859 -PAH 1.19519744629961e-10 -DRAM1 0.0807000769340284 -ARL1 0.480262743398917 -SYCP3 5.52621227683122e-05 -NUP37 0.000998328030395386 -HCFC2 0.994468276315441 -CHST11 0.398388040805651 -TCP11L2 7.48808798072002e-07 -POLR3B 2.72991445717276e-09 -NUAK1 0.189029672518911 -TDG 0.000922352403038787 -CKAP4 0.891862493984838 -RFX4 0.999662759432222 -EID3 0.237610982131272 -SLC41A2 0.913051821488741 -APPL2 3.52822991386898e-09 -KIAA1033 0.155503528869923 -NFYB 0.00327375770291337 -TXNRD1 0.00233754717803129 -GLT8D2 3.34398984119123e-07 -C12orf45 0.389486545133401 -ALDH1L2 3.50010213963042e-11 -RP11-144F15.1 0.0219762945567379 -ISCU 0.135947771003731 -CORO1C 0.997273678156858 -SART3 0.991709384753294 -PWP1 1.8549631577177e-05 -ASCL4 0.24741188917303 -MTERFD3 2.51773404015545e-06 -ALKBH2 0.000816686414241077 -RIC8B 0.997486826763253 -CMKLR1 0.0685269634408008 -CRY1 4.24281789472779e-07 -SELPLG 0.00495442531161246 -WSCD2 0.494025684101003 -FICD 0.00638582212011792 -TMEM119 0.00956737466521472 -BTBD11 0.99343298086277 -USP30 0.309014179184126 -DAO 9.26248223544675e-15 -PRDM4 0.833196847904435 -SSH1 0.987158740858356 -C12orf23 0.200504870049001 -MYO1H 2.91611360098295e-17 -TRPV4 7.31947219105235e-06 -ATP2A2 0.998230938512269 -ANAPC7 0.999257869586772 -FOXN4 0.133060550432118 -GPN3 0.000100471691467198 -FAM222A 0.400389071715135 -C12orf76 0.000101301333532111 -KCTD10 0.17266981342374 -ANKRD13A 0.350624808697698 -IFT81 5.76030312431944e-07 -ARPC3 0.931506660806945 -GLTP 0.22708870640821 -ACACB 5.12432725817776e-22 -UBE3B 0.00938770579237683 -GIT2 0.970632700807013 -MVK 0.0421613966473064 -UNG 0.0465811527139078 -TCHP 6.99625064835171e-12 -MMAB 0.00387716022324201 -RAD9B 3.62698610369545e-05 -HVCN1 0.750490678392491 -MYL2 0.0168131337644691 -FAM109A 0.00514982698391651 -ALDH2 1.73245219738394e-06 -ERP29 0.470649236214131 -SH2B3 0.00592218956138136 -CUX2 0.999656384592776 -TMEM116 1.14999091475817e-09 -TCTN1 1.86861398243824e-09 -PPTC7 0.354852283261299 -MAPKAPK5 0.0234226025504899 -CCDC63 4.48038323358414e-10 -ATXN2 0.999862271558356 -FAM216A 0.0011162985137716 -VPS29 0.934744447933042 -ACAD10 4.01457480802773e-20 -PPP1CC 0.944905081326266 -NAA25 0.999989964284881 -BRAP 0.0157033106581831 -LHX5 0.695818426257564 -DDX54 1.04148957531094e-06 -IQCD 7.66417947056825e-06 -TPCN1 0.00385891575421665 -HECTD4 0.99999999999996 -PLBD2 7.18473138561366e-08 -SDSL 2.99135817651197e-09 -RPH3A 0.738603478065915 -RPL6 0.98828827107104 -OAS1 0.00123924128980461 -OAS2 1.89091809637863e-14 -TRAFD1 1.82691525643369e-05 -RASAL1 4.85979006124582e-08 -SLC8B1 5.47604607149263e-10 -DTX1 0.00125591757009814 -SDS 0.00548426197624614 -PTPN11 0.999877230878678 -OAS3 1.82237568934062e-23 -C12orf52 0.000608069689464473 -FBXW8 8.69106598857506e-13 -RNFT2 0.790709970439595 -MED13L 0.999999998677147 -C12orf49 0.0452103165858912 -WSB2 0.503215469280486 -TESC 0.692139730962892 -NOS1 0.998694760625134 -FBXO21 0.990625618968859 -TAOK3 0.999977597504952 -TBX5 0.991878563864068 -VSIG10 5.54754892563778e-07 -RBM19 1.62207368798361e-05 -RFC5 0.01471033033263 -PEBP1 0.148864265050852 -MAP1LC3B2 0.0237056854362151 -KSR2 0.999946624685717 -SUDS3 0.00759610717840473 -TBX3 0.948925457312872 -PRKAB1 0.0518791329975909 -RPLP0 0.978691782887372 -RAB35 0.979782361188921 -COX6A1 0.0609575623120839 -DYNLL1 0.696580483081237 -MSI1 0.997146450593471 -GATC 7.79020409773576e-05 -CCDC64 0.549254948786093 -SIRT4 1.80676632025049e-07 -TRIAP1 0.590216383617478 -HSPB8 0.0277554701284337 -RP1-127H14.3 0.163512576517237 -PXN 0.00656841085846847 -CIT 0.999998739281467 -GCN1L1 0.999999998837185 -SRSF9 0.819638672376706 -CCDC60 8.62068411387964e-06 -SRRM4 0.411747626154712 -PLA2G1B 3.64893028626161e-11 -CABP1 0.994401234059643 -OASL 5.07293522290638e-12 -MORN3 1.82555353991208e-06 -KDM2B 0.999785914187162 -RNF10 0.502963048424231 -C12orf43 2.5600625299979e-07 -P2RX7 3.78969928544417e-06 -CAMKK2 0.503475917086193 -COQ5 7.95018460631921e-05 -ACADS 0.000162910285908926 -HNF1A 0.969659467322862 -ORAI1 0.00305335775445046 -SPPL3 0.907785634336426 -UNC119B 0.677325341021738 -MLEC 0.470920638317783 -ANAPC5 4.18001522765e-05 -P2RX4 2.36800653754896e-09 -RNF34 0.190893161577717 -POP5 1.28002317887135e-05 -B3GNT4 3.93670006882859e-06 -TMEM120B 0.264378756491141 -IL31 0.150887238101552 -DIABLO 0.000889964950590053 -LRRC43 6.70342212695841e-14 -HCAR2 0.0201092731074374 -SETD1B 0.0224563158915498 -CLIP1 0.96849601373118 -BCL7A 0.215729268155923 -MLXIP 0.975747589022912 -HCAR1 0.140999390466245 -RSRC2 0.992877361426345 -PSMD9 3.77628232193741e-05 -ZCCHC8 0.777819067262697 -VPS33A 0.687968695146875 -HPD 0.00776520567552076 -KNTC1 4.7771798324088e-32 -HCAR3 6.93117983208457e-06 -WDR66 1.2516451688474e-10 -RHOF 0.00520736033592633 -ARL6IP4 0.0112342008018869 -MPHOSPH9 0.000759987146945632 -DDX55 6.00815721436613e-06 -PITPNM2 0.999993632310422 -SBNO1 0.999999983699679 -ABCB9 0.00290110755910397 -SETD8 0.945359271397737 -RILPL1 0.0660195664772473 -GTF2H3 1.59171384172212e-05 -VPS37B 0.67680963728232 -CDK2AP1 0.74236102805821 -OGFOD2 3.80505928088838e-07 -TMED2 0.79767958829404 -C12orf65 0.17232858993411 -DENR 0.846252782580504 -CCDC62 1.43534739270012e-12 -EIF2B1 0.104796388339037 -HIP1R 1.442966534484e-06 -SNRNP35 2.28333241562555e-07 -RILPL2 0.0608721865653384 -BRI3BP 0.125132504957692 -TMEM132D 0.999010386532627 -NCOR2 0.999999722324534 -ATP6V0A2 4.73810629233338e-06 -UBC 0.704156666525431 -DHX37 0.978475417629788 -DNAH10OS 0.0133663892213768 -DNAH10 4.14031534574386e-37 -SCARB1 0.0772244034409674 -TMEM132C 0.667071880413267 -SLC15A4 2.99438982124826e-09 -AACS 4.2456926056096e-12 -TCTN2 1.97172300054813e-05 -FAM101A 0.212634236356269 -GLT1D1 9.15081325034839e-05 -PIWIL1 2.12575606834247e-07 -ZNF664 0.0016267937964256 -CCDC92 0.368849605751602 -TMEM132B 0.455834501099099 -GPR133 0.373629567284559 -EP400NL 0.0912207592458008 -RIMBP2 0.292582176020545 -RAN 0.95593796807508 -ULK1 0.964459663318906 -EP400 0.999999999883201 -SFSWAP 0.999425434016638 -POLE 1.00660603240353e-14 -PUS1 0.0199884225458712 -DDX51 2.27756414069476e-10 -P2RX2 9.69419848481171e-12 -PGAM5 0.03521668839589 -STX2 0.000386515733492941 -GALNT9 0.594228592829193 -MMP17 1.14744032526495e-06 -ANKLE2 7.47280326815163e-07 -PXMP2 0.0288943082845666 -GOLGA3 0.991564255599712 -ZNF140 0.00206505130454093 -CHFR 0.636712516541035 -ZNF10 0.000431500551933787 -CTD-2140B24.4 0.000562247977838478 -ZNF268 1.61651265255367e-09 -ZNF891 0.636347899240249 -ZNF605 0.960905074648588 -ZMYM5 0.200378134555614 -GJB2 1.02863295453376e-11 -IFT88 1.97189619737225e-08 -CRYL1 1.86752538837027e-05 -PSPC1 0.9926070201195 -MRP63 0.149929909009704 -IL17D 0.158810135100355 -GJB6 0.000189819676898347 -XPO4 0.999999613279938 -TUBA3C 0.00681759403629645 -SAP18 0.0457562409111712 -LATS2 0.869216004378958 -RP11-408E5.4 0.172474732490544 -ZMYM2 0.974459955902358 -N6AMT2 0.00099088008840384 -TPTE2 3.69447198098053e-08 -SKA3 2.99578704451869e-07 -MPHOSPH8 0.930242309438753 -GJA3 0.000279889069012082 -MIPEP 8.49063579888535e-07 -AL359736.1 0.481334586798072 -ZDHHC20 0.00233007066872882 -NUPL1 0.0848275553283195 -TNFRSF19 0.0198825133386579 -SGCG 0.00637038417637866 -RNF17 0.99999998654341 -C1QTNF9B 0.0400104739852192 -C1QTNF9 0.169231075575943 -FGF9 0.910715910113492 -PABPC3 3.37207246022607e-11 -CENPJ 3.02634315768328e-21 -ATP12A 9.71336645553994e-10 -PARP4 2.13341699280147e-20 -SACS 6.1462947887645e-12 -ATP8A2 0.418077899724509 -SPATA13 0.528844213374764 -MICU2 2.60205517637133e-13 -MTMR6 3.01310181922185e-06 -GPR12 0.852043161669527 -ATP5EP2 0.0224816072745641 -PAN3 0.999989677110545 -WASF3 0.960588201860343 -FLT1 0.997806027350573 -CDX2 0.553145867415221 -MTIF3 0.0296353067663883 -CDK8 0.946653349022173 -PDX1 0.522915815715109 -RNF6 0.170343293261201 -RPL21 0.920443069002851 -LNX2 0.215281596114596 -FLT3 0.609047700982651 -POLR1D 0.257868790684444 -USP12 0.79499196891634 -POMP 0.861423055957475 -URAD 0.00378363577582596 -SHISA2 0.404087524363213 -GSX1 0.0795564103198462 -RASL11A 0.00768974207631144 -UBL3 0.718099179817861 -MEDAG 0.000667054100444806 -HSPH1 0.983009121355496 -FRY 0.999999999958023 -B3GALTL 2.01556582308315e-10 -USPL1 0.491296980027037 -ALOX5AP 0.846184681895041 -KL 1.95267033273788e-05 -HMGB1 0.633893930973864 -SLC46A3 1.30472037835528e-07 -RXFP2 2.94175840947603e-08 -BRCA2 2.21312120661867e-15 -N4BP2L1 0.945268895282581 -SLC7A1 0.574964447374533 -KATNAL1 0.946326582546448 -PDS5B 0.99991240409457 -TEX26 8.72441908029966e-09 -MTUS2 0.330673093548944 -N4BP2L2 3.06127675841692e-06 -SPG20 0.000159489204272841 -RFXAP 0.439791636737197 -SERTM1 0.467667125905543 -CCNA1 0.00990629608655128 -MAB21L1 0.367416501981844 -POSTN 5.5233906383619e-05 -ALG5 0.00342997463732752 -SMAD9 0.000691360029213452 -DCLK1 0.961271824270266 -SOHLH2 0.429898601119812 -CCDC169-SOHLH2 0.429898601119812 -TRPC4 0.967651076497012 -EXOSC8 1.75847936308234e-05 -CSNK1A1L 0.000361793544139328 -NBEA 0.999999999999975 -SUPT20H 0.00138198819635341 -RFC3 0.000984459541916788 -STARD13 1.84668647836473e-07 -DGKH 0.818123800274802 -PROSER1 0.736135591768488 -NAA16 1.70534181115751e-10 -RGCC 0.0703969097546725 -VWA8 2.93154218637359e-40 -FREM2 1.25164781172615e-07 -FOXO1 0.966380393739249 -COG6 6.7206281668635e-10 -KBTBD7 0.223860925044712 -MRPS31 4.09360421604781e-05 -ELF1 0.547779993268523 -LHFP 0.463787541652463 -KBTBD6 0.934819360334992 -SLC25A15 0.00124731974401554 -AKAP11 0.896372711854258 -STOML3 1.97289725402202e-08 -NHLRC3 0.00380865629106237 -UFM1 0.464066114233379 -MTRF1 1.54398173133647e-07 -WBP4 0.000482126451524307 -CCDC122 8.65057685310611e-08 -LACC1 4.63538843291218e-06 -GPALPP1 0.000396088218762865 -SLC25A30 8.39152402794254e-06 -KCTD4 0.0407045021423859 -SERP2 0.229121363041921 -ENOX1 0.0364014174663741 -FAM216B 9.4200190421495e-05 -SPERT 0.000527781321155571 -EPSTI1 1.3509232083864e-18 -TPT1 0.946442279845925 -GTF2F2 0.0252302317679079 -COG3 0.999142795814268 -NUFIP1 3.91687077980072e-06 -TSC22D1 0.941151545615587 -SIAH3 0.00183208051769324 -TNFSF11 0.130191546680804 -DNAJC15 2.92123814107371e-07 -CAB39L 0.0164205539395948 -ITM2B 0.715126636356634 -HTR2A 0.772773609936333 -RB1 0.999999833394892 -ZC3H13 0.99999999999964 -SUCLA2 0.0306681591456276 -FNDC3A 0.999884367658408 -ESD 0.00061169243619552 -CYSLTR2 0.00155402110804489 -MLNR 0.0465876752547782 -CDADC1 6.88626543443745e-08 -NUDT15 0.0972295800796055 -KIAA0226L 2.02280092225205e-11 -LCP1 0.973076021263703 -MED4 0.06162002785339 -LRCH1 0.982396864430302 -CPB2 2.80849135453329e-06 -LPAR6 0.0304365240746065 -RCBTB2 7.21687231446053e-09 -KPNA3 0.809823934177535 -KCNRG 0.00052028933781877 -WDFY2 0.00359500151111569 -RCBTB1 0.000217673997703456 -DLEU7 0.0310204749254743 -EBPL 0.0388533331243391 -SERPINE3 0.00116717973839619 -ATP7B 5.23092252901538e-20 -SPRYD7 0.0911571663926814 -CCDC70 0.0531534616697279 -ARL11 8.09182009706795e-06 -INTS6 0.999996534735088 -RNASEH2B 1.29919624387268e-09 -PHF11 1.76757700990619e-05 -ALG11 0.000122134567519387 -DHRS12 0.00725776436102893 -SETDB2 0.0437301091973815 -TRIM13 0.505141848020281 -FAM124A 5.43000288891245e-07 -UTP14C 0.00117836245561414 -OLFM4 2.41040640655975e-06 -NEK3 5.05530998545056e-10 -VPS36 0.100608360734491 -PCDH20 0.88114907262702 -DIAPH3 1.2254557817215e-12 -HNRNPA1L2 6.70372795331927e-05 -NEK5 5.03282784249709e-20 -PCDH17 0.960498313002076 -LECT1 6.68267008491628e-06 -SUGT1 0.977752129164094 -THSD1 2.45031608890038e-05 -TDRD3 0.000211829294720341 -CKAP2 3.96231847753185e-08 -MZT1 0.611862318159052 -AL445989.1 0.172745643750502 -KCTD12 0.353531089443336 -PCDH9 0.97301427734079 -KLF5 0.871983359183675 -LMO7 0.0416242513975852 -KLHL1 0.00808344241005034 -DIS3 2.04523468343561e-11 -KLF12 0.982233162437981 -C13orf45 0.00981786503996022 -DACH1 0.995944076016472 -BORA 0.000692705153335445 -UCHL3 1.95224115097409e-05 -FBXL3 0.251434579423949 -PIBF1 4.97647085898113e-08 -COMMD6 0.131043402998848 -TBC1D4 3.64406926442853e-13 -CLN5 5.08087125944432e-06 -SLITRK5 0.812088308384531 -DCT 6.54969970498014e-12 -RBM26 0.999996998269038 -MYCBP2 1 -RNF219 2.48629783293926e-05 -NDFIP2 0.801878730067158 -TGDS 8.78036163423323e-06 -SLITRK1 0.988430445876677 -SLITRK6 8.60812958532084e-06 -SCEL 5.00221967904975e-12 -SLAIN1 0.959443821545465 -EDNRB 0.0193615215886145 -GPC5 1.99113939736555e-05 -ABCC4 0.0013146830739273 -SPRY2 0.930516838339553 -GPC6 0.338854613354057 -CLDN10 0.0459304128904221 -GPR180 6.5915409717463e-11 -RNF113B 0.135168377219133 -HS6ST3 0.747377572908153 -SLC15A1 8.68961113389547e-08 -DZIP1 3.32705692527064e-12 -UBAC2 0.11149235350166 -OXGR1 0.000863935505500482 -GPR18 9.91795601258391e-07 -RAP2A 0.71733965665019 -GPR183 0.0255456321889338 -TM9SF2 0.999928359846155 -DNAJC3 0.951080561997675 -IPO5 0.999998736678014 -STK24 0.79799829659642 -FARP1 0.0452630742628719 -MBNL2 0.900896116763864 -UGGT2 1.01866409514518e-21 -CLYBL 8.32420361913943e-06 -DOCK9 0.999999306507167 -EFNB2 0.938926864720003 -BIVM 6.43353311511258e-06 -FGF14 0.724525962590089 -KDELC1 6.41764150689518e-06 -TPP2 0.999863188903156 -ITGBL1 0.170877824203552 -ABHD13 0.637356652288557 -TEX30 0.00629544130857506 -PCCA 2.13324738593485e-10 -DAOA 0.00804524559202352 -FAM155A 0.80041532637658 -TMTC4 3.908551911016e-06 -LIG4 0.0021012376555408 -NALCN 0.000169004064103246 -ARGLU1 0.992267193125092 -ERCC5 4.64770040217028e-06 -METTL21C 3.55322885209736e-06 -SLC10A2 1.60745645494627e-13 -COL4A2 2.10928692329967e-06 -CARS2 0.0404651180857425 -RAB20 0.697708787502414 -TUBGCP3 0.952526133875611 -ATP11A 0.967333743318821 -TEX29 0.00145166750512405 -ANKRD10 0.127073151881964 -SPACA7 2.1004322887891e-06 -ARHGEF7 0.953985930517112 -COL4A1 0.99999998123739 -TNFSF13B 0.954794121426939 -CARKD 0.00650287988804953 -MCF2L 0.79554140444058 -ING1 0.0114357020023887 -C13orf35 0.00244696378299538 -MYO16 0.998667245865902 -RASA3 0.000433958644882729 -F7 1.3314119006302e-05 -PCID2 6.36502716196613e-09 -DCUN1D2 9.91158372964289e-05 -UPF3A 0.000813153350217953 -LAMP1 0.978974558833222 -TFDP1 0.963153120498646 -TMEM255B 3.85360358148072e-10 -CHAMP1 0.985193951059278 -PROZ 3.84163746031333e-09 -ADPRHL1 2.87960164870856e-07 -F10 0.160510707320587 -TMCO3 6.68498405104448e-10 -GAS6 0.333438602414211 -CDC16 0.952255349904704 -CUL4A 0.99941287660114 -ATP4B 1.84084732787283e-05 -GRTP1 4.78830161751861e-06 -GRK1 0.00915421207464947 -POTEM 0.784476802333841 -OR11G2 0.000228689713102011 -OR11H12 0.798398679764048 -OR4K1 2.21165537903248e-06 -OR4K15 0.635537854800151 -OR4K5 0.000430658354321092 -CCNB1IP1 0.183416412334859 -OR11H6 0.0210491564058505 -OR4N5 0.235716665504507 -OR4K13 6.75517891131211e-05 -TTC5 0.00249362475890097 -OR4N2 0.0737889122932416 -OR4M1 0.00516878743080707 -OR4K14 0.027453438192046 -OR4L1 0.00278340671476074 -OR4K17 0.047180154158617 -OR4K2 8.6747089870991e-06 -OR11H4 6.22542213030787e-05 -PARP2 2.09998835678433e-07 -RNASE10 0.013059518657014 -ANG 0.224577463484553 -TEP1 4.51417224704889e-24 -RNASE9 1.66649163366409e-05 -OR6S1 0.000222105368534211 -APEX1 0.000103582180068405 -PNP 0.0656268007332897 -RNASE4 0.00701713412897145 -OSGEP 1.79721398649986e-05 -EDDM3B 0.0185127670928452 -EDDM3A 2.78870436637145e-09 -RNASE6 5.43170259087741e-08 -TMEM55B 0.800399509827653 -RNASE1 0.161588976975498 -RNASE12 0.00683829902185725 -RNASE3 0.000178635535037144 -RNASE11 0.000992587146927763 -AL163636.6 0.125744484704797 -RNASE8 0.0051691020998071 -TPPP2 0.0171866165993747 -RNASE7 0.28044916605996 -METTL3 0.00100496545950933 -METTL17 5.78059529660905e-08 -RNASE2 0.0380227485132804 -SLC39A2 0.000671706229021376 -NDRG2 0.126597034289842 -RP11-998D10.1 0.0483260540112249 -CHD8 0.999999999998095 -RAB2B 0.000147821571275719 -ZNF219 0.988717808247592 -SUPT16H 0.999999605669678 -ARHGEF40 7.1856790203222e-05 -TOX4 0.811965790149349 -RNASE13 0.00115691527116493 -OR5AU1 1.41823424059493e-06 -HNRNPC 0.985848437293407 -RPGRIP1 2.57325929287003e-21 -ABHD4 7.5061622204536e-05 -PSMB5 0.758964107014505 -OR4E2 0.000222164124943235 -OR10G2 0.0460936473447754 -OXA1L 5.96038677388776e-09 -REM2 0.00050240605135054 -MMP14 0.987123657228178 -DAD1 0.276496725647528 -RBM23 4.62938214208565e-08 -C14orf93 0.0321277715658725 -SLC7A7 0.00209119496896398 -AJUBA 0.83340004755109 -OR6J1 0.40685269362071 -LRP10 0.000211411030039288 -OR10G3 0.234560474406909 -MRPL52 0.000108205112146637 -SALL2 1.78061422737665e-05 -PRMT5 0.994806432825256 -HAUS4 0.036809880472709 -BCL2L2 0.312495747576068 -PABPN1 0.599824569306877 -HOMEZ 0.342229011643787 -MYH6 1.27598576115295e-17 -C14orf119 0.0027616618278927 -ACIN1 0.999998436751071 -BCL2L2-PABPN1 0.425968450134784 -PSMB11 0.0171391308148329 -CDH24 6.70386871764034e-05 -SLC22A17 0.772286750668166 -MYH7 0.000145766291646031 -EFS 2.44587050452523e-06 -NGDN 6.84417480572023e-07 -IL25 3.62722298351536e-06 -CEBPE 0.00239237618926747 -SLC7A8 0.000166180404409209 -CMTM5 0.0600876421893113 -RNF31 0.999718687079344 -DHRS2 4.75351023968218e-06 -FITM1 0.072113818994595 -AP1G2 8.93514525478059e-14 -CPNE6 0.918263625967071 -PSME1 0.0508808333116453 -REC8 0.526977585048225 -PSME2 0.108796041514697 -DHRS4L2 0.357376761988657 -DCAF11 0.0714513191790591 -THTPA 0.000116051034701592 -IRF9 0.631965597852179 -LRRC16B 4.86594856632392e-05 -DHRS4 0.121200513498066 -JPH4 0.987347572961713 -IPO4 3.22469522365963e-06 -PCK2 2.18697220904741e-17 -NRL 0.0797351085798011 -EMC9 0.00035382769828854 -LTB4R2 0.000267452650893406 -ADCY4 2.37957783954271e-13 -RIPK3 2.24111545145836e-06 -NFATC4 0.985383663547882 -LTB4R 0.677367973216978 -TGM1 5.30650116807075e-07 -TSSK4 2.51468703195602e-11 -RABGGTA 0.00133984157846634 -TINF2 0.158554363406221 -RP11-934B9.3 0.00596515540794168 -NYNRIN 0.000549672204856649 -TM9SF1 0.000166484197400084 -GMPR2 0.000987612921603035 -CHMP4A 1.26405702868177e-06 -DHRS1 2.40813512310606e-10 -CBLN3 0.000188310725826416 -NOP9 6.32257639700667e-06 -CIDEB 1.51797420711163e-11 -MDP1 0.00152615928709452 -NEDD8 0.429440681272929 -GZMH 0.000213178163607732 -STRN3 0.447040096169006 -SCFD1 0.991579193827834 -G2E3 0.751141211279106 -KHNYN 1.39063137188499e-05 -CTSG 0.202072535708407 -STXBP6 0.0978976738904898 -RP11-80A15.1 0.108183260899262 -HECTD1 0.999999999999764 -COCH 0.000262849456488043 -GZMB 1.78750946382579e-06 -SDR39U1 7.40935818071384e-08 -PRKD1 2.12624005070963e-05 -CMA1 4.1077240038228e-08 -NOVA1 0.977721706151375 -RP11-176H8.1 0.172135496707513 -AP4S1 1.33545575036575e-07 -AKAP6 0.999936668135418 -NPAS3 0.980548669706538 -SRP54 0.996689717284175 -ARHGAP5 0.98705369807694 -NUBPL 0.00200988228068456 -PSMA6 0.943987639676727 -SNX6 0.965428129158632 -BAZ1A 0.999999774015725 -DTD2 0.00170814911545887 -FAM177A1 0.00206788278490877 -SPTSSA 0.571317620217307 -PPP2R3C 8.05791672286188e-07 -KIAA0391 1.7775756011591e-05 -EAPP 2.71832573208649e-05 -EGLN3 0.00264133555777407 -NFKBIA 0.97935202641697 -CFL2 0.164507783006843 -CLEC14A 0.000668541235966075 -PAX9 0.0880945051453336 -SLC25A21 6.47218604218705e-07 -SSTR1 0.829919497496787 -NKX2-1 0.0819264859161676 -MIPOL1 6.81655610731612e-06 -SLC25A21-AS1 0.387549574235059 -GEMIN2 0.00660919664980099 -PNN 0.163641787377565 -NKX2-8 0.243402674501059 -SEC23A 0.000127975825136816 -TRAPPC6B 0.0219802776295562 -SFTA3 0.294636981931893 -BRMS1L 0.368282761115449 -MIA2 0.000208820494041296 -TTC6 8.74475121291033e-09 -RP11-407N17.3 0.00613602032791982 -RALGAPA1 0.999999978076686 -MBIP 2.39687346293752e-05 -LRR1 8.60725001636742e-07 -FANCM 6.24486171840289e-12 -LRFN5 0.712324783241459 -POLE2 0.000153355971239164 -FSCB 4.81479388500392e-13 -RPL36AL 0.0418331992833221 -MDGA2 0.993216871367626 -FBXO33 0.986077142306714 -CTAGE5 0.00187636795944541 -RPL10L 0.0260549200341443 -FAM179B 2.88662498531604e-06 -PRPF39 0.995121732276915 -RPS29 0.349407010133348 -MIS18BP1 2.3000916264824e-05 -DNAAF2 4.78818341115889e-06 -C14orf28 2.0845213544728e-10 -MGAT2 0.955031701312776 -KLHL28 0.188871208958842 -FKBP3 0.812901762488181 -C14orf183 0.000343703213445726 -TMX1 0.00332853970137368 -SOS2 0.999427840971243 -PYGL 1.31337485605572e-09 -ABHD12B 3.28064370577763e-13 -MAP4K5 0.944269981947709 -AL627171.2 0.0887631612514117 -SAV1 0.777230367391595 -ATL1 0.99211803597583 -NIN 8.93549269098595e-06 -C14orf182 0.000354638787700124 -ARF6 0.600609559476142 -VCPKMT 2.61753927969878e-08 -KLHDC1 0.000148222869695322 -CDKL1 3.60337409896438e-05 -NEMF 0.981706446227217 -TRIM9 0.987914427877689 -ATP5S 6.3043463659782e-05 -L2HGDH 0.309969498152224 -KLHDC2 0.157958962045693 -BMP4 0.967466005226941 -GNG2 0.52377049107399 -DDHD1 0.968458213705181 -GPR137C 0.695444477253459 -C14orf166 0.666285715823714 -STYX 0.97206861803257 -PSMC6 0.995511977073858 -PTGER2 0.105022888329559 -GNPNAT1 0.00556740862247386 -PTGDR 4.02092917428872e-05 -GMFB 0.323144112210257 -FERMT2 0.999827199539689 -FRMD6 0.438403934830725 -CDKN3 0.0662974565528495 -NID2 6.95346797158758e-07 -TXNDC16 1.68997528709087e-07 -ERO1L 0.446965589250233 -CNIH1 0.843993720425153 -SAMD4A 0.999267731904104 -NAA30 0.97371507084361 -GCH1 0.942485932944866 -AP5M1 0.000108637306093947 -TBPL2 4.93486514101523e-08 -CGRRF1 0.00522692652830377 -PELI2 0.948506494774501 -TMEM260 5.88265833039317e-12 -DLGAP5 1.74110377765691e-05 -MAPK1IP1L 0.389494276372223 -KTN1 0.639772920815945 -FBXO34 0.00459847722302636 -SOCS4 1.85889470977039e-06 -OTX2 0.744599586946362 -WDHD1 1.82370607612634e-11 -EXOC5 0.996683024892685 -ATG14 0.326846073593547 -LGALS3 0.00017511393726883 -JKAMP 0.0598976863876527 -DACT1 0.81659755259209 -ACTR10 0.00473623657219373 -GPR135 0.00393204052879483 -TOMM20L 0.000787655427739962 -C14orf37 8.27235953361938e-05 -SLC35F4 0.00969257412732057 -L3HYPDH 1.52384322492068e-07 -C14orf105 0.000136147483752656 -PCNXL4 4.27002592047683e-16 -ARID4A 0.999999263100059 -DHRS7 1.22281963443987e-05 -TIMM9 0.437845525129567 -KIAA0586 1.44868459274921e-12 -RTN1 0.959599485657203 -PSMA3 0.99028192222966 -DAAM1 0.999990849460485 -SIX6 0.757754035338817 -MNAT1 3.96573933428392e-12 -TRMT5 0.965267929961933 -PRKCH 0.99439017871354 -SIX4 0.685504308249748 -PPP2R5E 0.999433463999183 -SNAPC1 3.82492140215155e-07 -SYT16 0.00124651789754824 -RHOJ 0.229657760958795 -SIX1 0.92637706377143 -SGPP1 0.500345892791711 -C14orf39 0.00852079034470034 -KCNH5 0.769049292397075 -PPM1A 0.985449561262778 -HIF1A 0.980689532418508 -WDR89 0.0001980885726453 -SLC38A6 6.10703569830496e-16 -TMEM30B 0.0211817301247061 -SYNE2 1.8533519422462e-11 -GPHN 0.999981472805078 -MAX 0.951898293348912 -RAB15 5.20750293834997e-06 -ATP6V1D 0.00315144323792958 -PLEKHG3 1.16377189060086e-08 -MPP5 0.660477587444664 -EIF2S1 0.916802002902544 -PPP1R36 2.76562693347729e-07 -FNTB 0.17200103905538 -GPX2 0.00231703379463956 -FUT8 0.997566109877212 -AKAP5 0.8411295400862 -CHURC1 3.13272051464755e-05 -ESR2 5.15440712040043e-08 -ZBTB25 3.31068569517812e-05 -ZBTB1 0.973423963579882 -MTHFD1 0.605609113854515 -SPTB 0.999999747900015 -EXD2 1.11026481255e-08 -ACTN1 0.999930573576069 -ERH 0.846059923578033 -KIAA0247 0.687192425148202 -GALNT16 0.0168277172834296 -RDH12 4.71469945442482e-06 -SLC39A9 0.529198523354405 -RDH11 0.00966533141048819 -VTI1B 0.209578768555067 -ZFP36L1 0.506697565301335 -ZFYVE26 1.03844572602961e-11 -PIGH 0.0698815809187974 -PLEK2 2.21898388320313e-08 -TMEM229B 0.214249970166916 -PLEKHH1 0.000660284566746353 -RAD51B 1.45736567534375e-09 -DCAF5 0.999968932331125 -ARG2 0.542999038189075 -RGS6 0.801361182566502 -DCAF4 0.00364518370773562 -SMOC1 0.00600403092020696 -RBM25 0.99999996714713 -COX16 0.0304599840487893 -MED6 0.0149679496565466 -PSEN1 0.997601160543998 -SLC8A3 0.621079527402869 -SIPA1L1 0.999999774320167 -DPF3 0.828481786371688 -PCNX 0.999999565127288 -SLC10A1 8.44088192990943e-16 -MAP3K9 0.92339517875996 -SRSF5 0.339129154603779 -ADAM21 0.0146728762806569 -SYNJ2BP 0.50394450911297 -TTC9 0.0585566584919598 -ZFYVE1 0.953726202611526 -ADAM20 1.79696117345216e-09 -PAPLN 5.13478634877696e-22 -COQ6 2.31087652552578e-07 -DNAL1 0.00640146907989069 -PNMA1 0.0593103724771047 -VSX2 0.116076832895677 -ENTPD5 0.000105198200581121 -PTGR2 7.20253305877724e-07 -CCDC176 0.000124143067055134 -ACOT6 0.00152388682505152 -ALDH6A1 1.62229467445935e-05 -ACOT2 0.142294697843995 -ACOT1 0.0359991659838093 -LIN52 0.891966387273143 -NUMB 0.0243991693428803 -FAM161B 9.86041048036769e-11 -ACOT4 4.21463209007871e-08 -HEATR4 6.23228339805708e-17 -ZNF410 0.661705780560574 -ELMSAN1 0.999772779607384 -ABCD4 1.39849213579456e-08 -PGF 0.898304164411566 -NEK9 1.19201671010644e-06 -VRTN 0.858358428932427 -AREL1 0.0118020841149469 -ISCA2 6.27266246447634e-05 -TMED10 0.718151478052545 -PROX2 7.88534780140081e-07 -NPC2 0.00870069266662882 -LTBP2 0.0187346880945461 -MLH3 0.000425002178066797 -SYNDIG1L 0.00366418236769666 -ACYP1 0.223001663900667 -FOS 0.435710740653144 -FCF1 0.934256694936662 -EIF2B2 0.000428255871835589 -YLPM1 0.999933059355471 -DLST 0.95039365180288 -RPS6KL1 0.000674280963305879 -ZC2HC1C 1.62188208850506e-06 -C14orf1 0.891783234105691 -ESRRB 0.542080991203377 -JDP2 0.856106109996034 -NGB 0.00253179978703355 -TMEM63C 0.988496791803572 -VASH1 0.730608113503456 -GSTZ1 1.06852258414363e-05 -KIAA1737 0.226034705693039 -BATF 0.744904919744278 -TGFB3 0.92271748369888 -C14orf166B 2.17584254850766e-07 -IRF2BPL 0.968935346112199 -ZDHHC22 0.318481044811824 -TTLL5 1.97990564092488e-09 -FLVCR2 0.000368276215601782 -GPATCH2L 0.539068808366984 -IFT43 4.37841580307519e-07 -POMT2 0.000130414429321649 -ANGEL1 3.05586566551492e-10 -SEL1L 0.704308255469323 -STON2 0.568326467737997 -GTF2A1 0.956765261830397 -VIPAS39 0.000534939494815586 -NRXN3 0.999855500755767 -SPTLC2 0.820593934643991 -AHSA1 0.938521220776593 -SNW1 0.999633196215809 -NOXRED1 0.118495407678092 -DIO2 0.217796806901725 -SLIRP 0.000361057844318624 -ISM2 1.26338885002286e-05 -C14orf178 0.00852342418083104 -SAMD15 2.34405461457857e-06 -ALKBH1 2.13146607160804e-05 -TSHR 5.80341698067131e-06 -ADCK1 4.22838319274286e-09 -CEP128 4.09190040207887e-18 -TMED8 0.0843249980243263 -RPS6KA5 0.999801806584297 -FLRT2 0.894038333573428 -KCNK13 0.258007859554083 -PTPN21 2.36179668693425e-07 -FOXN3 0.907799359973324 -GALC 6.28347214969704e-07 -SPATA7 3.13904072808556e-09 -TTC8 0.345392611801702 -TDP1 1.11209643921476e-11 -NRDE2 6.49344106983731e-10 -CALM1 0.894820172867617 -GPR65 0.505440551202977 -TTC7B 0.999902561387641 -PSMC1 0.995728890599096 -ZC3H14 0.999785297023323 -EFCAB11 0.0202622727133803 -EML5 0.158418534732481 -KCNK10 0.00757969172842383 -CHGA 0.000145486160271026 -LGMN 0.00097489450100372 -ITPK1 0.987051326793078 -CATSPERB 4.2621545768236e-13 -CCDC88C 2.17322769994979e-06 -GOLGA5 0.363133884753824 -C14orf159 2.06971538888579e-14 -ATXN3 0.176363907956847 -NDUFB1 0.311678002538598 -SLC24A4 3.16711232181816e-06 -SMEK1 0.998771820725125 -AL133373.1 0.522343672603738 -TC2N 0.0121893285015318 -MOAP1 0.00140363613553352 -GPR68 0.000219036510559383 -TRIP11 2.34458214955102e-09 -RIN3 0.000276829502107209 -FBLN5 0.995790692927138 -CPSF2 7.81001536480669e-05 -SERPINA10 1.21176106869289e-05 -OTUB2 9.30774599769382e-06 -PRIMA1 0.367086765780191 -SERPINA6 5.27007649744634e-07 -ASB2 4.58910505820339e-05 -IFI27L2 0.00150740100387573 -SERPINA11 1.4053679123183e-07 -UBR7 0.426811632119051 -UNC79 0.999999999973909 -PPP4R4 0.00567425479283036 -C14orf142 0.190974080812774 -IFI27 0.0561856088767235 -IFI27L1 0.076473377797993 -BTBD7 0.682366256826822 -FAM181A 0.0249838634471543 -SERPINA1 3.65586459511635e-07 -COX8C 0.144098451101148 -TMEM251 0.0771120001365747 -DDX24 0.221392665021272 -DICER1 0.9999945509466 -BDKRB2 0.269901202726925 -TCL1B 0.00468673143485725 -GSC 0.0697083404726596 -GSKIP 0.718816129437916 -SERPINA9 1.79474750647935e-09 -RP11-404P21.8 0.0226071204924502 -ATG2B 8.12742750734489e-05 -TCL1A 0.0012233048337285 -SERPINA3 5.34007170592001e-12 -GLRX5 0.626214086667008 -BDKRB1 0.07010469248697 -CLMN 2.06352661935763e-07 -SERPINA4 1.58265231800216e-07 -SERPINA5 0.0526385833218062 -SERPINA12 7.46593117503427e-06 -SYNE3 2.9457549334185e-15 -HHIPL1 0.00214437023105914 -BCL11B 0.929785241868294 -CYP46A1 0.754693330684111 -SLC25A29 0.00606097276523407 -SLC25A47 3.17553796647681e-12 -PAPOLA 0.999971689697056 -AK7 9.78990970793468e-09 -WARS 0.994700675309381 -YY1 0.967830954926674 -SETD3 0.371891002606027 -VRK1 0.0428984052164855 -C14orf177 0.00674701538541544 -EVL 0.992615269783271 -DEGS2 0.00586427408044219 -WDR25 0.0422261097836064 -CCNK 0.997144332155116 -EML1 0.999446460294898 -BEGAIN 0.890710074727172 -TNFAIP2 0.00267820839495161 -DYNC1H1 1 -DIO3 0.768046570846978 -TECPR2 0.948515859986564 -ZNF839 9.18902348869399e-05 -DLK1 0.400971249953363 -WDR20 0.939272872591341 -AMN 0.0923578355683243 -TRAF3 0.998405668636195 -CDC42BPB 0.999999999630375 -RCOR1 0.994042794940819 -PPP2R5C 0.997672663482247 -RTL1 0.00816648413128806 -ANKRD9 0.180354468492622 -HSP90AA1 0.676747646700996 -EXOC3L4 3.12925255065406e-07 -MOK 5.96438032193124e-17 -CINP 0.00276924897730325 -ZFYVE21 0.713442898007109 -ASPG 1.18217261186296e-06 -RP11-73M18.2 0.0070525462787843 -KLC1 0.51495533247325 -PPP1R13B 0.976929374224392 -APOPT1 0.000361375806098766 -KIF26A 0.41090369131392 -TDRD9 3.82298905718051e-07 -EIF5 0.907859809790479 -XRCC3 6.31832524034568e-08 -TRMT61A 0.00570206467721117 -CKB 0.85084546139957 -TMEM179 0.278562205449867 -C14orf180 0.0134314304920118 -BAG5 0.0432181879837962 -C14orf2 0.658634629667739 -MARK3 6.11449031625676e-05 -BTBD6 0.000422096018258331 -NUDT14 0.000705232590146412 -CDCA4 0.499553162512056 -BRF1 0.634632788081496 -CEP170B 0.870509859679243 -C14orf79 5.1346210352029e-08 -INF2 0.999083287804995 -CRIP1 0.0013579599192347 -JAG2 0.990248880592838 -ADSSL1 0.000383323420631864 -SIVA1 0.313588965101933 -MTA1 0.999747857218867 -GPR132 0.0347124102896783 -AKT1 0.980206587064648 -PLD4 1.23030186248079e-13 -CRIP2 0.00507027849660397 -PACS2 0.999324515491581 -TMEM121 0.178807336241636 -C14orf80 0.00122228120574754 -NIPA1 0.214097495852355 -GOLGA8I 0.263870337812603 -GOLGA6L2 8.97094503942648e-06 -MAGEL2 0.922411269035569 -NIPA2 0.487193753650621 -OR4N4 0.0180506007874978 -CYFIP1 0.994933031618259 -TUBGCP5 0.000126197167194763 -GOLGA8S 0.00466261611098299 -NDN 0.470364294438916 -NPAP1 0.273009365565849 -GOLGA6L6 0.0868643024684935 -RP11-467N20.5 0.398578851671092 -POTEB2 0.571892791435193 -SNURF 0.780882316345501 -SNRPN 0.848259450842786 -MKRN3 0.0235775059313367 -GABRA5 0.951529195038544 -GABRB3 0.997073960271659 -GOLGA8J 0.355056850110703 -NDNL2 0.195522567139285 -GOLGA8H 3.19984019621833e-05 -HERC2 1 -GABRG3 0.993679844208636 -GOLGA8M 0.920983506421717 -ATP10A 0.611013499237766 -APBA2 0.0735269721652979 -UBE3A 0.999576243958304 -GOLGA8T 0.76143467128854 -GOLGA8Q 0.480898386722338 -GOLGA8R 0.175047823831853 -GOLGA8F 0.559396882573985 -OCA2 7.67937025845118e-12 -TJP1 0.999999982283293 -GOLGA8G 0.447085283334208 -MTMR10 0.0350497967234235 -KLF13 0.629113650372402 -SCG5 1.07115773193623e-05 -EMC7 0.935651560043946 -AVEN 5.70186245131166e-08 -GREM1 0.711099436104345 -ARHGAP11A 0.124921593849902 -FMN1 1.72654491663651e-13 -OTUD7A 0.97459544138619 -FAN1 1.46792582485245e-15 -TRPM1 1.16831980652389e-31 -RYR3 0.999999945238815 -ARHGAP11B 0.0721323428905467 -GOLGA8K 0.337642789863851 -PGBD4 5.90742356728259e-05 -CHRM5 0.00383197171202466 -ACTC1 0.946770308539104 -SPRED1 0.868668326243136 -EMC4 0.912468200149828 -RASGRP1 0.189676970174086 -C15orf41 0.0155525648224664 -ZNF770 0.82751324661339 -GOLGA8B 0.280132444754512 -FAM98B 0.394827182699865 -NOP10 0.802013758916469 -DPH6 0.00246862782790718 -GJD2 0.1177216002599 -KATNBL1 0.0141547394809675 -GOLGA8A 0.693302517089581 -AQR 0.999998819889607 -LPCAT4 0.996222992113105 -TMCO5A 0.000421006608369141 -MEIS2 0.994254955106549 -SLC12A6 0.97817997330196 -NUTM1 0.00598112649294294 -C15orf53 0.0936098085913799 -THBS1 0.999073127290828 -EIF2AK4 8.32742943473465e-10 -C15orf52 0.0025769414685249 -GPR176 0.413262635237383 -BMF 0.354021066182312 -SRP14 0.83539573119462 -BAHD1 0.991930031952242 -C15orf54 0.000115195661974805 -C15orf56 0.0517037024480086 -PAK6 0.00128179098336292 -CHST14 0.594619350621838 -KNSTRN 3.15834140854417e-07 -IVD 1.7312786559084e-11 -DISP2 0.0162511640768809 -FSIP1 4.51252744804813e-07 -PLCB2 3.01690271048763e-12 -BUB1B 0.00263162333228221 -RPUSD2 0.000105170590634246 -CHAC1 0.000276505596595412 -ZFYVE19 7.40857843667129e-09 -VPS18 0.939243017183049 -GCHFR 0.0418968845933878 -SPINT1 0.00152362991906225 -OIP5 1.53697409243863e-08 -RMDN3 0.023779597676249 -C15orf57 0.611394297335686 -PPP1R14D 0.0303416533365849 -INO80 0.999999999807578 -CASC5 0.0237167187203929 -CHP1 0.228123191828265 -DLL4 0.982859473655879 -DNAJC17 0.0285392981407643 -NUSAP1 0.00510251786113418 -EXD1 2.0333200373386e-13 -RAD51 0.99041808754591 -RHOV 0.590311998511154 -MAPKBP1 0.999024889896837 -GANC 2.37915434464825e-21 -PLA2G4F 1.39975398074621e-09 -EHD4 0.00149680577068074 -PLA2G4B 9.15662350167561e-25 -PLA2G4E 2.28331485083454e-06 -RPAP1 5.01588405270387e-15 -CAPN3 9.73741042585956e-09 -MGA 0.999999999646878 -TMEM87A 0.785702662224374 -JMJD7 0.23431095695057 -ITPKA 0.821022368669755 -JMJD7-PLA2G4B 9.15662350167561e-25 -PLA2G4D 6.29227608353161e-10 -NDUFAF1 0.00389629034560786 -RTF1 0.993637763534383 -TYRO3 0.761822542682681 -VPS39 0.000738264521045905 -LTK 4.12009149040216e-21 -SPTBN5 1.09010380481407e-70 -ADAL 8.52495696643507e-09 -TGM5 5.36528605073887e-16 -TTBK2 0.996929374509573 -LRRC57 0.000686890124895267 -TMEM62 5.98675580191077e-08 -ZNF106 0.219458519047887 -MAP1A 0.999688997602479 -LCMT2 7.26615001081782e-08 -CCNDBP1 0.0372725464260417 -CDAN1 0.928144193175439 -ZSCAN29 2.29379256843049e-06 -TUBGCP4 0.00528348188155799 -HAUS2 0.00140043242000112 -TGM7 6.34381866870598e-10 -UBR1 0.319889980799525 -SNAP23 0.826507888875192 -PPIP5K1 0.102604913232572 -TP53BP1 0.999855964238627 -EPB42 1.56180488450141e-07 -FRMD5 0.991843164486017 -CKMT1A 0.0141217929367762 -C15orf43 0.000137584911341295 -TRIM69 1.96411504084879e-10 -CASC4 0.000967729828290193 -STRC 0.00532184460844672 -SPG11 2.91203449273578e-22 -WDR76 0.00230519074795657 -CATSPER2 3.0443890998245e-05 -B2M 0.856561948026764 -PDIA3 0.959251419181895 -ELL3 3.17480785408243e-06 -SERINC4 0.0107594286376223 -PATL2 0.0677100893702347 -SERF2 0.138975962472976 -CKMT1B 0.0732106469813755 -EIF3J 0.859084260110388 -MFAP1 0.986958816915287 -CTDSPL2 0.995978213604988 -HYPK 0.021030750002461 -BLOC1S6 9.82041840454567e-06 -DUOX1 1.97275277824694e-13 -C15orf48 0.000404124925714789 -SHF 0.0280832658607613 -SLC24A5 3.20459293064119e-05 -DUOX2 1.8967607743652e-37 -SLC12A1 2.65435277088282e-07 -DUOXA2 1.49970920077282e-07 -MYEF2 0.999492304383741 -DUOXA1 0.000109720453384831 -SLC30A4 0.950659466932893 -SLC28A2 9.71272786078653e-12 -GATM 0.866491076784892 -SORD 0.00434794621162012 -SPATA5L1 4.79851298392042e-11 -SQRDL 1.09952685912782e-05 -SEMA6D 0.999469975966626 -USP8 0.999982628555187 -AP4E1 0.979862099052625 -GALK2 8.74120031890395e-06 -FAM227B 2.74008557766254e-16 -COPS2 0.999572843395694 -CEP152 4.42004196778011e-21 -DUT 0.339206865298345 -TRPM7 1.65553537627815e-08 -SPPL2A 0.0470779338673946 -SHC4 1.16969936608024e-05 -DTWD1 1.4054382775955e-05 -SECISBP2L 0.10171305162342 -HDC 0.514822964237295 -USP50 1.23258212279927e-14 -ATP8B4 2.42164394305674e-27 -FGF7 0.874992687904998 -FBN1 1 -GABPB1 0.929888310247904 -SLC27A2 2.58257558060631e-05 -EID1 0.64535520974644 -MYO5A 0.992129667219065 -ONECUT1 0.209132853423149 -DMXL2 0.999999999395933 -UNC13C 3.68783135222941e-07 -TNFAIP8L3 2.33259080551193e-06 -LYSMD2 0.256648623702389 -GLDN 1.79271352388512e-11 -ARPP19 0.269804297590526 -LEO1 0.999605969713844 -BCL2L10 0.000387594966865579 -GNB5 0.00144292854144753 -TMOD2 0.138407691231062 -RSL24D1 0.946909507265446 -MYO5C 4.34872218862826e-18 -WDR72 1.62243924822237e-16 -MAPK6 0.533146358713183 -TMOD3 0.804645652132819 -CYP19A1 0.000559609707897891 -SCG3 0.267523893167639 -FAM214A 0.96699856876149 -PRTG 0.0195291074116393 -ZNF280D 0.820128047448904 -NEDD4 6.44185120812023e-09 -TEX9 2.58827295083548e-17 -TCF12 0.973899934245985 -LIPC 0.000171127202456162 -MYZAP 2.21367341168049e-09 -C15orf65 0.360932047574078 -CCPG1 0.962563038904312 -CGNL1 9.04937499888625e-14 -RAB27A 8.23365144303053e-05 -AQP9 0.446614670928057 -GCOM1 3.95491169061382e-09 -ALDH1A2 0.516630055977224 -POLR2M 0.169086388609866 -DYX1C1 4.61254731939258e-07 -PIGB 0.000232191988748325 -RFX7 0.999680946335938 -MNS1 5.52556154828089e-14 -PYGO1 0.956651521929469 -ADAM10 0.999844506827148 -C2CD4A 0.0888058026911242 -NARG2 7.45310367928049e-08 -BNIP2 1.6929996956937e-05 -RNF111 0.999889183334039 -TLN2 0.999853230773704 -VPS13C 1.8552278256612e-37 -GTF2A2 0.386341515138839 -RORA 0.953196549708048 -GCNT3 4.04466927083348e-09 -SLTM 0.999996386807791 -FAM81A 0.487072320130673 -CCNB2 1.58542348538884e-06 -FOXB1 0.702812387833519 -C2CD4B 0.496545386662587 -ANXA2 0.00984346288196249 -LDHAL6B 7.95326404010906e-07 -MYO1E 0.0479778930717418 -FAM63B 0.189061306036796 -HERC1 0.999999999998371 -USP3 0.984379976108001 -APH1B 0.000234972220416475 -TPM1 0.79947002234679 -CSNK1G1 0.999715378765103 -ZNF609 0.999945906955907 -LACTB 0.00265961207919234 -SNX22 0.00792254750515989 -CTD-2116N17.1 0.993204961098791 -SNX1 0.939839944686599 -RAB8B 0.0495152480226271 -FBXL22 0.000439659300268727 -RPS27L 0.335851901877477 -DAPK2 0.000134613269112973 -KIAA0101 0.129504562347457 -TRIP4 3.04197168353347e-07 -FAM96A 0.0134508962309797 -PPIB 0.0106515280164213 -CA12 9.91295957492359e-09 -OAZ2 0.866153028384412 -PLEKHO2 0.0047538423246732 -DPP8 0.999271312821212 -PDCD7 0.045374793576378 -ANKDD1A 1.16107189225281e-15 -SPG21 9.88307687455965e-05 -CLPX 0.766826744088607 -PIF1 7.57989172819851e-12 -PTPLAD1 0.317556680796292 -MTFMT 0.000216329665423534 -RBPMS2 0.323534851132986 -PARP16 1.92817785078927e-08 -IGDCC3 0.000233060205949579 -KBTBD13 3.34282857078106e-05 -IGDCC4 0.0148854979044506 -SLC51B 0.222197461674156 -CILP 1.39584747557031e-19 -VWA9 0.00309381266728039 -RASL12 0.00696822152010853 -SMAD3 0.868268313208796 -SNAPC5 1.40204453241569e-05 -SMAD6 6.96558203122398e-06 -TIPIN 0.00983208458317475 -SLC24A1 0.000127201012282332 -LCTL 4.65245462491966e-08 -DENND4A 0.00135462134565384 -MAP2K1 0.994501270366062 -AAGAB 0.00810207313151983 -MEGF11 2.5182184269378e-24 -IQCH 2.69347323550457e-12 -ZWILCH 8.31163921804795e-06 -RPL4 0.999281603608024 -MAP2K5 0.475918460790794 -RAB11A 0.983220856534547 -DIS3L 1.29328456685495e-10 -RP11-315D16.2 0.0603629160049464 -KIF23 0.999999790749235 -THAP10 0.00119434425578864 -SPESP1 1.97658953424779e-05 -NOX5 1.72408872311278e-13 -THSD4 0.00181827156769691 -LRRC49 0.446510312132105 -CORO2B 0.779053736737647 -TLE3 0.999913536986372 -ITGA11 0.000116168936373859 -PIAS1 0.997024481652262 -PAQR5 0.153782976698066 -CLN6 0.381706051281562 -UACA 2.35035184982735e-17 -LARP6 0.882216412282497 -GLCE 0.327374271928511 -CALML4 0.0102090578324751 -FEM1B 0.540948666821381 -RPLP1 0.680907046710861 -ANP32A 0.973870035856712 -CT62 0.0331981608348203 -BBS4 0.000141017368072284 -CD276 2.0220262891725e-05 -PARP6 0.997418877545242 -GOLGA6B 0.302338863626375 -SENP8 0.257288612865091 -NEO1 0.99985462014738 -ARIH1 0.999665081826237 -HEXA 5.04679454539172e-07 -ADPGK 0.0221562951088713 -C15orf59 0.244691481801632 -HIGD2B 0.0943807874236842 -C15orf60 0.00343584386758435 -GRAMD2 2.95954761695704e-08 -HCN4 0.234597783260834 -PKM 0.994197406281851 -CELF6 0.376807001276073 -NPTN 0.9889178530056 -MYO9A 0.999991725771394 -TMEM202 6.15971402190463e-07 -UBL7 0.0277554399688677 -CYP11A1 6.60264967270784e-09 -CYP1A1 1.97289145995058e-07 -ARID3B 0.964041164914236 -ISLR 0.000436481987652303 -STOML1 5.52734629268276e-05 -CLK3 0.928146533223461 -PML 0.937511028933986 -EDC3 0.635930663137711 -GOLGA6A 0.224411353907766 -LMAN1L 1.8808952583686e-09 -CYP1A2 3.28540807222054e-10 -STRA6 3.24590579415562e-08 -SEMA7A 0.0253934009542489 -CCDC33 8.63487200520327e-09 -TBC1D21 0.0223267587117133 -CSK 0.999458351904314 -NEIL1 0.000108858344700828 -RPP25 0.00695757715935081 -SIN3A 0.99999994122779 -COX5A 0.324238692730719 -MAN2C1 2.94181816484649e-25 -PTPN9 0.9862836143924 -SCAMP5 0.345427472674241 -FAM219B 0.00122765065389532 -C15orf39 0.919030415254172 -IMP3 5.33334042533681e-05 -ULK3 0.0169271585091179 -PPCDC 0.00087960119376272 -SNUPN 2.17760843039441e-10 -MPI 0.000142827839143154 -GOLGA6C 0.0400514301413968 -GOLGA6D 0.318585416071094 -SCAMP2 0.383700654337713 -COMMD4 0.237758189788472 -SNX33 0.00675714431845481 -CPLX3 0.385406550550488 -C15orf27 1.47913813182816e-08 -PSTPIP1 0.000726150105344361 -NRG4 0.0243875467702028 -ETFA 0.0129272726537226 -TBC1D2B 6.50996889622544e-05 -ODF3L1 5.18159832927925e-07 -UBE2Q2 0.00105603997354618 -SCAPER 0.0392828983920439 -ISL2 0.329330132128272 -TSPAN3 0.284424065158703 -CIB2 0.000468492983005407 -RCN2 0.449457626519201 -CSPG4 8.89722030167291e-05 -FBXO22 0.893814403062287 -LINGO1 0.952116231457105 -PEAK1 0.760544632953527 -SH2D7 0.0014209813173193 -HMG20A 0.932476251384682 -CHRNA5 2.40946932670794e-06 -CRABP1 0.12550489400582 -IREB2 0.999999730362402 -KIAA1024 0.000865675748600288 -DNAJA4 3.56777071333241e-05 -TMED3 0.00265674208825899 -CHRNB4 0.0186266094522454 -RASGRF1 0.999614037089254 -MTHFS 0.0406510504988124 -IDH3A 0.230948359529529 -ADAMTS7 2.98948787387487e-07 -CTSH 3.17314560149624e-06 -ST20-MTHFS 0.0363712829836564 -CHRNA3 0.00706163755884019 -HYKK 0.000214856084289355 -MORF4L1 0.802941002940311 -PSMA4 0.620423590120457 -ACSBG1 0.00670029816274961 -WDR61 0.0897745791618097 -EFTUD1 0.0336556752499839 -IL16 3.12223515361747e-05 -ARNT2 0.959019737658223 -ZFAND6 0.218468572768346 -MEX3B 0.201034761193953 -TMC3 9.78337319544272e-16 -C15orf26 0.835174203743573 -FAM154B 2.33650714833831e-09 -KIAA1199 1.74567014622841e-09 -ST20 0.113592063518993 -ABHD17C 0.84082862967754 -BCL2A1 0.481233411410349 -MESDC1 0.683511245523063 -FAH 2.80762381206333e-11 -MESDC2 0.846200196402005 -STARD5 0.0615971183814048 -C15orf37 0.302687830203454 -SH3GL3 0.000359349545380338 -FSD2 2.36468713050695e-12 -WHAMM 1.0362469004489e-05 -C15orf40 0.268492643273296 -AP3B2 0.990065569960768 -BNC1 0.886168665378858 -HDGFRP3 0.939816244400543 -FAM103A1 0.82844521510956 -GOLGA6L10 0.368958940189802 -ADAMTSL3 9.55133265504144e-09 -HOMER2 0.0545468794795003 -BTBD1 0.0149464237355017 -CPEB1 0.999591314438397 -TM6SF1 6.46941313206752e-05 -KLHL25 2.20160691373916e-10 -ZSCAN2 0.0182037038018536 -GOLGA6L4 0.389324704197603 -MRPL46 8.03007555320251e-07 -ALPK3 3.54006995242909e-09 -AKAP13 0.849566020351285 -NMB 0.156904105323652 -PDE8A 0.713477056622093 -AEN 6.06475830868436e-08 -ISG20 0.00609138684425968 -AGBL1 3.60066917773009e-23 -DET1 0.542030761589873 -SEC11A 0.173327554548954 -WDR73 7.90217939379774e-06 -ZNF592 0.949422558472883 -MRPS11 0.000434481626027353 -ACAN 0.999993944546979 -SLC28A1 6.34799091474105e-07 -NTRK3 0.978536238427813 -TICRR 9.15261267789813e-12 -KIF7 4.15765422074511e-08 -MESP1 0.000120662134814298 -ZNF710 0.943123584694422 -C15orf38-AP3S2 1.03619222630726e-09 -MESP2 0.0114095574924346 -PEX11A 5.93762026210222e-07 -POLG 4.12449812767026e-05 -AP3S2 0.000230909983075112 -HAPLN3 3.91721530857888e-06 -IDH2 0.376558105362484 -FANCI 5.16501380164005e-19 -PLIN1 3.5584340242688e-07 -ANPEP 0.00024424182711579 -RLBP1 5.41120505102986e-05 -C15orf38 5.27461779889361e-06 -WDR93 6.27428968004137e-15 -ABHD2 0.849463720274095 -MFGE8 0.000594281860541287 -RHCG 4.90789526315851e-06 -FES 2.77390387287312e-05 -MAN2A2 3.60787631910875e-09 -GDPGP1 8.68771623153128e-06 -FURIN 0.999933300929352 -UNC45A 9.49307248350221e-08 -GABARAPL3 0.01940596500072 -NGRN 0.0224062148151509 -ZNF774 1.10144667279176e-10 -IQGAP1 0.999976584550565 -SLCO3A1 0.732171682691697 -HDDC3 0.0718306276352796 -SEMA4B 0.00160800069630225 -SV2B 0.534784655278294 -BLM 4.13859674040892e-11 -CRTC3 0.983929956417642 -CIB1 0.0161029646482789 -RCCD1 1.62554312815351e-05 -TTLL13 5.30191022031425e-11 -PRC1 0.015975839505285 -VPS33B 2.91337145537518e-09 -FAM169B 0.00135689866124102 -MEF2A 0.737169983273076 -TTC23 4.35102174486449e-16 -ARRDC4 0.000815443122975903 -C15orf32 0.00550955422560942 -FAM174B 0.00994225008853275 -IGF1R 0.552974259646112 -PGPEP1L 6.97508611499858e-06 -ST8SIA2 0.512756894405073 -SPATA8 0.158580482360026 -CHD2 0.999999998845422 -MCTP2 7.9294335387251e-41 -LRRC28 8.59828754914425e-05 -SYNM 2.32891148971373e-12 -RGMA 0.010575528851855 -NR2F2 0.916704230117823 -ASB7 0.993244100438513 -RP11-89K11.1 0.35594142957861 -OR4F15 0.205470537627522 -VIMP 4.99881344822127e-11 -CHSY1 0.913667234012375 -CERS3 0.000441004567942562 -LYSMD4 1.73218412498145e-05 -TARSL2 2.85774106307975e-09 -ALDH1A3 0.924100685142389 -OR4F6 1.34347941087799e-05 -LINS 3.2552399684157e-05 -OR4F4 0.54595605565204 -LRRK1 1.5909507477274e-05 -ADAMTS17 3.82852764002745e-11 -SNRPA1 0.969077644208195 -PCSK6 0.0104695863094061 -TM2D3 0.00033899537761085 -HBM 0.00684674520290924 -MRPL28 2.41661968324225e-08 -POLR3K 0.324223634570766 -MPG 4.23694995903237e-09 -RHBDF1 3.65345577837932e-06 -NME4 0.134065501683573 -HBZ 0.0166772462869549 -PDIA2 2.52932710736602e-21 -LUC7L 0.164212796735953 -ITFG3 2.74181380558442e-05 -NPRL3 0.468162601085399 -AXIN1 0.247772063902675 -TMEM8A 0.000118507458791397 -HBA2 0.448693557225498 -SNRNP25 0.00747804113002767 -ARHGDIG 0.486229755044962 -WASH4P 0.472112531877142 -RGS11 1.25776709985289e-09 -HBA1 0.511601563401791 -HBQ1 0.00582839332902991 -RAB40C 0.113249055305225 -PIGQ 3.38787210295676e-10 -WDR24 0.00470241623358303 -NHLRC4 0.00242750693328775 -JMJD8 3.79963968099618e-10 -WDR90 4.01805540497848e-46 -RAB11FIP3 0.99624251258264 -FAM195A 0.0533617873640192 -CCDC78 1.71263612100492e-19 -STUB1 0.0425338864217666 -CAPN15 0.965209511170234 -C16orf13 0.00453725397293647 -C16orf11 1.27243702382816e-05 -FAM173A 0.00048241002631383 -METRN 0.0818044356695418 -RHOT2 9.27430835542939e-12 -WFIKKN1 4.90281884604666e-08 -RHBDL1 0.494734021596252 -FBXL16 0.95155737500943 -DECR2 3.46558531082418e-09 -LMF1 1.14509473311795e-14 -NARFL 1.04511224704187e-05 -HAGHL 0.000148930109473316 -PRR25 3.12896569287399e-06 -UBE2I 0.943944487319045 -BAIAP3 2.20929624637849e-19 -TPSB2 2.34678788202538e-08 -MSLNL 3.46249568874859e-16 -TSR3 0.00240758156123533 -RPUSD1 3.05727308154375e-08 -TPSG1 4.08951910541866e-06 -GNG13 0.00489277449013945 -C1QTNF8 8.97840847891757e-11 -SOX8 0.873708460070314 -CACNA1H 0.755916975722347 -TPSD1 8.52216628919943e-09 -SSTR5 0.0623344657131591 -TPSAB1 4.56498117493005e-05 -MSLN 2.47687992428564e-15 -IGFALS 2.79990921598618e-05 -HAGH 0.000143398287880002 -TMEM204 0.902171044906255 -FAHD1 1.1922677900771e-08 -PTX4 1.77530402250970e-12 -GNPTG 5.99621775569544e-08 -UNKL 0.0988570192094062 -NME3 2.37397506636629e-06 -EME2 9.50138363079845e-14 -MAPK8IP3 0.999999970922629 -IFT140 9.13769895125714e-18 -CLCN7 0.981282976462541 -C16orf91 3.85106439476045e-07 -CCDC154 0.311572586421122 -TELO2 4.84231495536262e-07 -CRAMP1L 0.95454193553226 -NUBP2 0.00881682223602247 -MRPS34 5.52343942722583e-05 -SPSB3 0.514185341856129 -HN1L 0.516099964468604 -TRAF7 0.460647228032184 -SLC9A3R2 0.0227037623698413 -MSRB1 0.00310471105797646 -PKD1 0.999905331991465 -SYNGR3 0.292054618656317 -RNF151 3.79966413724101e-07 -NDUFB10 0.0466299139856533 -GFER 1.85054644807578e-06 -TBL3 1.53647496342632e-06 -TSC2 0.999999983432509 -MEIOB 9.45110442754297e-07 -HS3ST6 0.00322375385292522 -NTHL1 1.76610950574232e-09 -CASKIN1 0.999956295373995 -NOXO1 3.17355817693735e-11 -RPL3L 2.13545692074586e-08 -MLST8 0.629654086289634 -RPS2 0.236872070471978 -RAB26 3.5573777860374e-06 -ZNF598 0.201673229572794 -DNASE1L2 2.27540813731848e-07 -TCEB2 0.0207842917252483 -KCTD5 0.544871003960432 -PGP 0.757807855144398 -BRICD5 1.62461586129841e-10 -E4F1 0.434844067114666 -ABCA3 7.47762721295469e-08 -NTN3 5.82214181383073e-05 -RP11-20I23.1 1.14601456627331e-07 -ECI1 4.20005738223802e-10 -CCNF 0.0243519280324674 -RNPS1 0.94850298717449 -PRSS27 8.68860972407141e-07 -ATP6V0C 0.729144944239477 -TBC1D24 5.84284760412081e-07 -C16orf59 1.91727702821914e-08 -AMDHD2 2.64249958224576e-07 -PDPK1 0.952237847594102 -CEMP1 4.83642669335331e-09 -PRSS22 0.0154763640761076 -MMP25 1.64577846493364e-06 -CLDN6 0.0104295146810942 -KREMEN2 0.414292182077592 -CLDN9 0.0599270027261919 -PAQR4 6.76132750226625e-05 -ZNF213 0.000112000376515533 -HCFC1R1 0.000463237063043746 -ZNF205 0.141235328324468 -FLYWCH2 0.580537079882413 -IL32 3.7703925155889e-07 -TNFRSF12A 0.036421306731277 -PRSS21 3.27226707337438e-07 -ZG16B 0.00409470688609179 -PRSS33 0.000160243696997293 -THOC6 0.00219344761881848 -ZSCAN10 0.00606606191767312 -PKMYT1 0.667410731013562 -CCDC64B 5.72990223004394e-06 -ZSCAN32 1.15987515680798e-05 -CLUAP1 0.000219540497279212 -OR2C1 0.0975481717862837 -TRAP1 1.62037604789736e-17 -NLRC3 1.03344697218477e-12 -DNASE1 1.00614589458506e-11 -NAA60 0.908883491873174 -SLX4 8.90319772055342e-08 -OR1F1 8.87979193240061e-05 -C16orf90 0.00240644832042289 -ZNF174 0.0530328588222394 -TIGD7 1.86840685100942e-07 -CREBBP 0.999999999999794 -MEFV 1.12014488205382e-08 -ZNF263 0.00818051568357078 -ZNF200 2.25120499760497e-06 -ZNF75A 0.0002034845611094 -ZNF597 0.134235996654177 -MGRN1 0.450177891211047 -NUDT16L1 0.0204493837015027 -CDIP1 0.734505012174229 -CORO7-PAM16 1.62821439778502e-12 -VASN 0.0538071657238598 -SRL 0.00123342684996184 -SEPT12 4.59207575683259e-10 -C16orf71 1.37813829884911e-13 -C16orf96 0.0702878052319574 -DNAJA3 0.3856771260961 -ZNF500 0.000679411301142229 -PAM16 0.144011543598339 -GLIS2 0.953068391479354 -CORO7 7.31151184071541e-12 -UBALD1 0.700158646161822 -ADCY9 0.974310442484441 -ANKS3 0.0123556103986193 -HMOX2 0.0011006560316462 -TFAP4 0.978529176157973 -NMRAL1 0.000731170681969894 -C16orf89 2.03997402633687e-14 -PMM2 4.03082648601013e-10 -NAGPA 2.86322915528202e-07 -C16orf72 0.98608139706383 -ABAT 0.374368506048295 -FAM86A 1.04290878938485e-11 -GLYR1 0.999877719491225 -GRIN2A 0.99804480805101 -METTL22 3.9572283065224e-08 -TMEM186 0.00140985400566882 -UBN1 0.997776757027546 -PPL 1.07536873356769e-25 -ROGDI 3.12930827517025e-12 -RBFOX1 0.935961018293749 -SEC14L5 6.56646738092541e-10 -ALG1 9.21962630765385e-10 -USP7 0.999999998411863 -PRM1 0.371061724240126 -TNP2 0.0439713399621792 -RP11-166B2.1 1.60247876077471e-08 -CIITA 5.54341952880924e-05 -RSL1D1 0.000364294182041933 -GSPT1 0.951655491719969 -NUBP1 6.66279855269194e-08 -EMP2 5.89781732945459e-05 -RMI2 0.0246041881131188 -TVP23A 2.04412659815965e-06 -PRM2 0.108047166399074 -CLEC16A 0.0101389568529136 -DEXI 0.45368757225915 -TXNDC11 0.00317800786829343 -ATF7IP2 0.797518042342298 -TEKT5 1.10256706066914e-14 -SOCS1 0.541775584805038 -LITAF 0.313932119355222 -SNN 0.0202490590604754 -ZC3H7A 0.999987024834243 -MKL2 0.999938115504898 -BFAR 0.00230974824450457 -NPIPA1 0.495053838627117 -PARN 0.387183623172132 -TNFRSF17 0.00310441854162779 -RRN3 0.000474580439094432 -NPIPA5 0.544994923114436 -NTAN1 0.0158736622184606 -PLA2G10 0.0217477326167779 -SNX29 1.78492586400224e-06 -PDXDC1 2.30260183441473e-07 -MPV17L 0.000500982038571006 -ERCC4 3.33157717442271e-10 -CPPED1 3.25892031250431e-10 -C16orf45 0.214680178058486 -ABCC6 1.4545670403957e-06 -ITPRIPL2 0.0185033935717135 -KIAA0430 0.999999565958546 -TMC7 4.32157674955598e-06 -ARL6IP1 0.00667568860937067 -ABCC1 0.0194357604713981 -COQ7 4.67860434510292e-05 -SMG1 0.999999999999956 -MYH11 0.998956488496709 -FOPNL 9.46709362306996e-06 -XYLT1 0.985159711217428 -NDE1 0.0471095482859516 -RPS15A 0.833355704516176 -GPRC5B 0.527206905590426 -KNOP1 3.16682440044249e-05 -GDE1 4.09186346553975e-05 -UMOD 3.18086247757233e-08 -CCP110 0.015731918368029 -ACSM2B 8.65856451993107e-06 -C16orf62 1.28585119520756e-05 -ACSM3 4.97906453643603e-09 -IQCK 0.0539326256943501 -GP2 1.13365800269189e-12 -SYT17 0.0236363497033387 -ACSM2A 2.48680424010888e-06 -GPR139 0.144423629277907 -ACSM1 4.36748438392005e-09 -TMC5 0.000196303180727183 -THUMPD1 0.00103546307155391 -ACSM5 5.09254067683109e-08 -PDILT 9.26418194186399e-06 -OTOA 4.15629802750077e-08 -PDZD9 0.545260624608038 -UQCRC2 0.00723554333965841 -NPIPB3 0.502865157452298 -IGSF6 0.0725547810761045 -TMEM159 0.00317402725667112 -POLR3E 0.0194658182232362 -DNAH3 9.63057947571572e-51 -LYRM1 1.7941553165101e-05 -METTL9 0.377292454639358 -ZP2 1.04418610251881e-05 -ANKS4B 3.41490609436488e-06 -ERI2 6.38834089545038e-05 -AC004381.6 9.23173414430862e-07 -DCUN1D3 0.89815410326792 -VWA3A 1.83741135853222e-20 -EEF2K 8.33829176238637e-11 -CRYM 0.0271487843921294 -HS3ST2 0.212162588155993 -COG7 1.28698924936735e-06 -NDUFAB1 0.755255332218331 -RBBP6 0.999999002580924 -TNRC6A 0.999999927980856 -GGA2 5.0464979295437e-05 -PALB2 1.32628496864351e-10 -UBFD1 0.839698364238153 -CHP2 0.00659125634654492 -SCNN1B 0.000701536553027014 -EARS2 2.07046774730899e-07 -DCTN5 0.0204374093932638 -CACNG3 0.987801232112246 -PRKCB 0.999908070013039 -USP31 0.00875110488790412 -ERN2 1.79313065351506e-15 -PLK1 0.994120613063786 -SCNN1G 0.368698568765529 -CDR2 5.60529124829684e-06 -ZKSCAN2 0.00293767473426787 -GSG1L 0.541032304996425 -NPIPB7 0.151766813480617 -NPIPB6 0.636136511561843 -AQP8 0.00384821561717584 -ARHGAP17 0.990465510536605 -IL4R 0.0317438326163225 -HS3ST4 0.581015604864414 -IL21R 0.846367843553844 -SBK1 0.437577104080955 -KIAA0556 1.30820565996232e-17 -SLC5A11 1.49641187474707e-06 -XPO6 0.999999448411066 -CLN3 9.99316042821659e-07 -LCMT1 0.00155058401962153 -NSMCE1 0.0383884146167725 -KDM8 0.00726458481834173 -GTF3C1 0.999995618775871 -ATXN2L 0.999950395532872 -CCDC101 0.867208408499443 -EIF3C 0.34330310885051 -SULT1A2 1.83502409355329e-08 -SULT1A1 2.23675804808239e-09 -CD19 0.853622376519338 -IL27 0.927792677629213 -NUPR1 0.00754108860242725 -NPIPB8 0.0142295046002752 -APOBR 6.29744462573012e-06 -LAT 0.0974332943635584 -RABEP2 0.00273664449583801 -TUFM 0.651456012209132 -SPNS1 0.25844682511651 -NFATC2IP 0.00232734526476926 -SH2B1 0.956829709593037 -ATP2A1 7.03974863284906e-09 -SPN 0.0912713919603563 -KIF22 4.39968359378374e-06 -PRRT2 0.301735693046838 -C16orf54 0.668080507728988 -TMEM219 0.00103535655502854 -TAOK2 0.998764492352461 -QPRT 0.593365505826568 -KCTD13 0.79196093357248 -CDIPT 0.193882539034725 -SLX1B 0.516792296405978 -PAGR1 0.500965910941921 -MVP 0.00744852498762191 -ASPHD1 0.120035612549071 -MAZ 0.953969621751156 -SEZ6L2 0.130153160381108 -SULT1A4 0.392852564478597 -HIRIP3 0.0190027818505393 -SULT1A3 0.372332179105009 -PPP4C 0.759585900442172 -INO80E 0.0174146851193449 -SEPT1 0.00293746552059533 -YPEL3 0.122709138935465 -FAM57B 0.285736245520272 -CORO1A 0.954491479297814 -ALDOA 0.0248344029134968 -DOC2A 0.0185536457979363 -SLX1A 0.625453893215557 -CD2BP2 0.000336174209255009 -C16orf92 0.018925440394968 -TBX6 0.0291474892908083 -MAPK3 0.409692328374644 -TBC1D10B 0.98178412798823 -GDPD3 1.05164952856676e-07 -MYLPF 0.602001132166449 -C16orf93 8.00214162666554e-05 -SEPHS2 0.00178605301440582 -ZNF747 2.75423162490336e-05 -PRR14 0.258591291316777 -DCTPP1 0.184698213695084 -ZNF689 0.318737330058287 -ZNF785 3.83915416323042e-14 -ZNF629 0.992317751805668 -BCL7C 0.150443662576109 -RNF40 0.999994909279865 -ZNF688 7.08656311553746e-05 -PHKG2 0.0216344941814238 -ZNF768 0.579305580172895 -ZNF764 3.06788723152273e-08 -ZNF48 0.0324251458384005 -ITGAL 0.430339544018475 -ZNF771 0.295812869272627 -SRCAP 0.999999997075562 -FBRS 0.981524681800076 -CTF1 0.138254693826932 -TRIM72 0.000530648274852266 -PYCARD 0.0165035542141555 -FUS 0.999963786341319 -PRSS53 7.27161895996479e-11 -ORAI3 0.0109506896081293 -PRSS36 4.42359099895437e-13 -PYDC1 0.465269917823027 -C16orf98 0.136322270597882 -ZNF668 0.26889237334633 -KAT8 0.912576387976251 -SETD1A 0.999996231355084 -STX1B 0.944474732619076 -HSD3B7 4.6418471440819e-06 -PRSS8 0.00338430962613161 -ZNF646 0.00556536047832854 -VKORC1 0.0818030758329219 -STX4 9.66202483351248e-05 -FBXL19 0.982522202972825 -BCKDK 0.00580435804002904 -ITGAM 1.33563852516558e-08 -MYLK3 0.14096753512483 -C16orf58 1.17704527811772e-10 -TP53TG3D 0.641056795781585 -AHSP 0.00985693954905296 -VPS35 0.993599132125856 -ZNF267 1.49136799306776e-06 -ITGAX 6.11156995762923e-05 -TGFB1I1 0.0749169191152651 -ARMC5 0.0462924745566781 -SLC5A2 8.34847516316556e-11 -ITGAD 6.33151638988354e-12 -SHCBP1 5.5265911035503e-06 -ORC6 0.000734225790234647 -COX6A2 0.549091486087313 -ZNF720 0.0559604563285243 -HEATR3 0.000127664947241789 -PHKB 3.16119097774812e-10 -LONP2 2.90605573607261e-16 -C16orf78 4.18701427806165e-06 -SIAH1 0.949054584763539 -DNAJA2 0.985455360988873 -ADCY7 0.0177212075002422 -CBLN1 0.814123266644296 -N4BP1 0.361226867556661 -CNEP1R1 0.291176144907272 -NETO2 0.158399551223246 -C16orf87 0.097478781929178 -ZNF423 0.990468533215048 -ABCC12 2.20535216082614e-26 -GPT2 0.00368564013628491 -ABCC11 5.69831059947564e-25 -PAPD5 0.99850644091945 -ITFG1 0.962023993456245 -NKD1 0.997929798892685 -BRD7 0.944865043331553 -CAPNS2 0.131736738431294 -SLC6A2 0.277118300003759 -RBL2 0.957797035589511 -MMP2 0.791258492355506 -SNX20 4.12728270614269e-05 -CHD9 0.999999928588994 -RPGRIP1L 1.19937665171712e-18 -NOD2 5.52076952261577e-19 -CYLD 0.994720107012035 -FTO 0.0113445756239307 -CES1 6.76997200580057e-14 -IRX6 2.81616051778102e-08 -TOX3 0.99433910835596 -LPCAT2 1.12519142457894e-06 -SALL1 0.994674178309957 -AKTIP 0.788012645511726 -MT1E 0.659212996447356 -SLC12A3 5.54410952233344e-18 -OGFOD1 1.29448940600909e-08 -MT1B 0.248269442186515 -AMFR 0.00142575921262617 -MT1H 0.0548412149416522 -NUP93 0.00486804388235231 -BBS2 1.8525443177165e-10 -MT1A 0.0077761859390121 -MT1F 0.0538496988016702 -MT1X 0.0496111915968201 -MT1G 0.00811948407601034 -HERPUD1 0.82104286595303 -MT3 0.254133469605707 -MT4 0.0079945846958122 -MT1M 9.83543934507332e-05 -MT2A 0.0538691874978182 -CES5A 5.95161189606759e-19 -GNAO1 0.98428817684836 -NUDT21 0.947296445770822 -NLRC5 6.71793792873124e-05 -CPNE2 0.544003069972159 -RSPRY1 0.999778005187676 -ARL2BP 0.000774155836962192 -GPR56 1.43215749807167e-05 -POLR2C 0.0470077256392426 -KATNB1 0.496734037043629 -CIAPIN1 0.296605891863902 -GPR114 0.0143235613548936 -COQ9 0.000172325245964419 -CETP 5.18056762742226e-12 -GPR97 4.47697685472301e-09 -CCL22 0.279053454796883 -FAM192A 0.944099351189242 -PLLP 0.519581851885049 -CX3CL1 0.963378216670433 -CCDC135 1.63901907520071e-11 -DOK4 0.197602909551512 -CCL17 0.0771247220885551 -CCDC102A 9.21570601625823e-05 -TEPP 6.79569807856734e-05 -CCDC113 3.94970170501918e-13 -C16orf80 0.0244964105838873 -NDRG4 0.0198090719902488 -ZNF319 0.959545481290559 -CDH11 0.999267144964547 -CNOT1 0.99999999999948 -PRSS54 4.49967790564216e-05 -SETD6 1.02142648154529e-09 -USB1 0.12277471565959 -GINS3 0.236040219115464 -SLC38A7 0.0314056926915209 -CNGB1 6.63008798434668e-25 -KIFC3 0.467893120006523 -CDH8 0.997463771271808 -MMP15 0.651305092372326 -GOT2 0.896491160129866 -CSNK2A2 0.999154189421807 -CDH5 0.146020817838369 -CMTM1 0.00129753085731742 -FAM96B 0.00210375204791455 -CMTM2 2.07069164121887e-05 -CMTM3 0.107243308615464 -NAE1 1.90378758487526e-07 -CES2 1.07504051110477e-10 -CKLF 0.0270931084047075 -CMTM4 0.0393834626167364 -PDP2 1.86119178038611e-05 -TK2 0.00326975294791418 -CDH16 6.80363206242921e-13 -RRAD 0.310768743276529 -CES3 2.05758710215349e-08 -CA7 0.77537597388821 -CKLF-CMTM1 0.00802844948907333 -DYNC1LI2 0.798419344341552 -CES4A 0.000495399061913583 -B3GNT9 0.0228246541729955 -LRRC36 3.63105528140864e-10 -FHOD1 9.46042582987411e-11 -KIAA0895L 0.0184330576803288 -LRRC29 0.00720375911547779 -FBXL8 0.0144390750003526 -E2F4 0.320999401239657 -CBFB 0.905733874306119 -AC040160.1 0.344279000504123 -KCTD19 3.3389213065673e-08 -PLEKHG4 1.46441415776125e-09 -SLC9A5 0.0362519257358633 -ELMO3 1.20206324348469e-07 -TRADD 0.680264799376384 -EXOC3L1 7.64087796717592e-10 -NOL3 0.0005364757507069 -C16orf70 0.80354551663145 -HSF4 2.50047825950513e-10 -TMEM208 0.424874172613488 -ZDHHC1 5.10929019814853e-06 -NUTF2 0.885150385053397 -FAM65A 0.895578365834564 -HSD11B2 0.244955464937436 -CENPT 0.0553623518797919 -ACD 5.77980161685066e-07 -AGRP 0.0903872520171276 -TSNAXIP1 9.27238409136455e-18 -RLTPR 0.0223533069911047 -THAP11 0.465632985581296 -ATP6V0D1 0.988131750847399 -ENKD1 2.15383278184853e-05 -TPPP3 0.311517277242007 -NRN1L 0.000386710849157266 -CTCF 0.997924957852537 -C16orf86 0.652428951452165 -RANBP10 0.951824229348564 -PARD6A 0.854734700838115 -EDC4 0.995195899401119 -GFOD2 0.0605374338437669 -CDH1 0.338547688109087 -NFATC3 0.998062457612728 -CTRL 7.86917801865378e-06 -SMPD3 0.659196149583207 -DPEP2 4.01062336318903e-05 -SLC7A6OS 0.807327025070433 -CDH3 1.8060327648012e-08 -TANGO6 9.71153123642061e-09 -ZFP90 0.00886192807104427 -SLC7A6 0.0224285001107606 -LCAT 0.496435716280553 -PSMB10 2.33997900720924e-05 -DUS2 0.000272032398658379 -DDX28 0.0348937305744781 -DPEP3 9.13571963954139e-07 -ESRP2 0.731424518577173 -PRMT7 8.30563679212495e-09 -PLA2G15 0.658429999883026 -SLC12A4 1.82559229552341e-07 -PSKH1 0.0178742052133664 -WWP2 0.977902374453959 -VPS4A 0.912320744087044 -TERF2 0.927472177448586 -CIRH1A 0.0940277046265138 -CHTF8 0.275816998725164 -NFAT5 0.999990941723713 -SNTB2 0.036218317626175 -CLEC18C 0.876992461970907 -PDF 0.0503154180966918 -NQO1 4.52404699215664e-11 -EXOSC6 0.49417393399594 -NOB1 8.61136358207129e-08 -CYB5B 0.259577989859624 -HAS3 0.26938711218293 -NIP7 0.603152382697747 -CLEC18A 0.144113695415487 -PDPR 4.85026223543158e-08 -COG8 1.87304071695129e-05 -TMED6 0.000563599382674353 -COG4 4.38858303424531e-06 -AP1G1 0.999975846160012 -ST3GAL2 0.947101298960924 -SF3B3 0.999962978336449 -AARS 4.67831529001667e-05 -MTSS1L 0.86986055007454 -FUK 8.47562895767482e-16 -IL34 0.114215553005568 -CMTR2 1.4241642942685e-07 -MARVELD3 0.000303793592671722 -CALB2 0.00123890128989255 -TAT 0.0214384440123944 -VAC14 0.629700168448247 -PHLPP2 0.0157973198741475 -CHST4 5.59232486282113e-09 -ZNF23 8.37282562295769e-07 -ZNF19 1.78277433532571e-05 -DDX19A 0.92306130907744 -DDX19B 0.0357117798271904 -GLG1 0.997711423693009 -FA2H 0.726409723584695 -PMFBP1 4.06292657665862e-25 -TXNL4B 0.0173065222001966 -HPR 2.94872175113387e-07 -IST1 0.0231106718602087 -WDR59 3.44164260304723e-11 -ZFHX3 0.999999999859262 -DHODH 0.0128239089226836 -MLKL 7.47865621818672e-14 -RFWD3 0.525273498714844 -ZNRF1 0.754396423016752 -PSMD7 0.0193323505913806 -NPIPB15 0.00027793232809077 -ZNF821 0.158430832731393 -DHX38 1.03801324416004e-06 -HP 0.0293907467277115 -MON1B 0.229740475197793 -CHST5 0.00538022490291957 -SYCE1L 0.0721375071730236 -BCAR1 0.992956578294104 -TERF2IP 0.0227973012542949 -CFDP1 0.0849395818350133 -ADAT1 6.80340090282039e-11 -CTRB1 0.00179667178430693 -TMEM231 7.38492812005148e-05 -KARS 0.0859078130308862 -CNTNAP4 2.3431154940654e-05 -CHST6 0.000606606828678051 -LDHD 4.48718498001763e-06 -GABARAPL2 0.000743181272649561 -CTRB2 0.283515252776286 -ZFP1 0.00925162312350236 -NUDT7 0.00010793192750074 -VAT1L 1.89787043215691e-05 -TMEM170A 0.000303172215493796 -ADAMTS18 3.73935058124161e-15 -GCSH 0.0197283428790772 -HSBP1 0.530903532161435 -CMC2 0.00149210999958192 -WWOX 1.93855273615458e-08 -CDYL2 0.624960005081721 -MAF 0.429001156450398 -DYNLRB2 0.390767288946825 -C16orf46 5.35421701391956e-06 -CMIP 0.999886587184176 -PLCG2 0.999993046683293 -BCMO1 8.7309891857971e-07 -GAN 0.036349933633412 -MPHOSPH6 0.00120843421582984 -CENPN 3.16047315352104e-05 -CLEC3A 5.3221672233597e-07 -HSD17B2 3.82582400367301e-10 -CDH13 0.217594377239137 -PKD1L2 2.36605828568027e-09 -SDR42E1 3.52616114391235e-07 -ATMIN 0.000970632527072967 -CRISPLD2 7.37608592707666e-06 -KCNG4 3.97041784376579e-17 -HSDL1 0.000929031159036312 -KIAA0513 0.0758306424438943 -TLDC1 2.2902052991234e-12 -ADAD2 6.70177251389337e-05 -TAF1C 3.23271531745362e-11 -FAM92B 3.59457728092944e-11 -OSGIN1 0.0160506254451066 -KLHL36 0.939925902191205 -USP10 0.98885345266455 -MBTPS1 0.131749475403802 -DNAAF1 5.41468353704791e-06 -MLYCD 0.000280848275880868 -ZDHHC7 0.00507412524920815 -WFDC1 2.97211981376766e-06 -COTL1 0.0667591515201751 -FOXL1 0.0639302371886436 -SLC7A5 0.508496599514066 -FBXO31 0.911167117005807 -C16orf74 0.0240486458910046 -KLHDC4 3.7052834500335e-19 -CA5A 0.0107231379680564 -JPH3 0.986177997424036 -COX4I1 0.722238025462968 -ZCCHC14 0.94883572655475 -FOXF1 0.909443996784091 -EMC8 0.25900842753047 -MAP1LC3B 0.0617608767755467 -IRF8 0.926540237878288 -GINS2 6.07718456409909e-09 -MTHFSD 3.76450383104559e-09 -BANP 0.958647667807905 -APRT 4.71819943938473e-10 -CYBA 0.00357298293939449 -CDH15 5.96232075451435e-12 -ZC3H18 0.999519575544442 -PABPN1L 2.65471049687625e-11 -CTU2 3.21676727020384e-14 -GALNS 0.000862039524473656 -CBFA2T3 0.454440081718265 -RNF166 0.551620567355592 -CDT1 7.76436067319038e-09 -ZFPM1 0.0314918366014913 -ACSF3 1.37225554153478e-15 -TRAPPC2L 3.55188444434469e-05 -SNAI3 0.00830565937296694 -MVD 2.16344313538101e-12 -PIEZO1 0.535969010144802 -IL17C 0.000566477094969951 -SPATA33 2.72892869796854e-06 -VPS9D1 0.00176648362917067 -ANKRD11 0.999999821632236 -CHMP1A 0.252036809419505 -SPIRE2 1.1281776245309e-10 -DPEP1 0.000136492958599163 -MC1R 3.24606043304287e-07 -ZNF276 0.000257274838666869 -RPL13 0.914867444922444 -FANCA 2.08124711168363e-34 -SPG7 1.38467339967464e-18 -SPATA2L 0.0469218644980502 -TUBB3 0.960789307391211 -TCF25 0.0517782774404855 -ZNF778 1.63414262887613e-15 -CPNE7 1.63023438294019e-13 -CDK10 2.3367075460824e-10 -PRDM7 3.13626272886712e-10 -CENPBD1 0.0200720946377584 -DBNDD1 0.000234996408377196 -GAS8 8.03531596883606e-08 -DEF8 0.389991487866254 -C16orf3 0.00279281097473673 -SLC43A2 0.0618427043068134 -MYO1C 3.89020504800004e-08 -INPP5K 0.0133887227764052 -RPH3AL 5.10573723225223e-10 -FAM57A 0.0207651978444373 -DOC2B 0.382719811977725 -VPS53 4.99655044931933e-05 -CRK 0.864536311467028 -YWHAE 0.964161141960601 -TUSC5 0.101235964074607 -PITPNA 0.929437924643375 -GEMIN4 1.88601867514957e-07 -C17orf97 2.02508049711868e-05 -ABR 0.999949479085503 -NXN 0.86063738959499 -TIMM22 0.00362100661079949 -RNMTL1 1.81967911622819e-07 -GLOD4 8.10949511197997e-05 -TSR1 8.33290388723747e-20 -SCARF1 0.000660074291001061 -SMYD4 2.00564150829446e-11 -OVCA2 3.94781518236935e-05 -RTN4RL1 0.787530525426807 -RILP 0.000670859753110892 -SGSM2 5.55963371668394e-08 -SMG6 0.999935136420641 -MNT 0.96048045983846 -DPH1 2.34177044084966e-08 -SRR 0.179017047265105 -PRPF8 0.999999999219228 -SERPINF1 8.28899615258178e-05 -RPA1 0.308711195767143 -SERPINF2 0.423433542043792 -WDR81 1.26010739829094e-05 -AC006435.1 5.85500603405754e-05 -METTL16 0.997289420410487 -PAFAH1B1 0.99963285344523 -OR1A1 0.000357575232051276 -ASPA 0.0148801566444315 -OR3A2 0.564393310538053 -OR1E1 0.111199867995703 -OR3A1 0.0295684605043502 -TRPV1 5.63846239630988e-14 -OR1A2 0.0132146515884 -OR3A3 0.416001527528029 -OR1G1 0.00871100712695252 -TRPV3 8.74042179448203e-14 -SPATA22 0.000465618314810027 -OR1D5 0.712159402893277 -SHPK 3.97287394987282e-06 -CLUH 0.999701830275383 -RAP1GAP2 0.95593855271305 -OR1D2 0.00238256215176167 -CTNS 0.0341220085738078 -TAX1BP3 0.00234803255540852 -OR1E2 0.0208740723340844 -SPNS3 2.77218256786725e-10 -CYB5D2 4.57076963496539e-05 -P2RX5 1.83109272499805e-05 -SPNS2 0.00382444023834242 -ARRB2 0.769282968108594 -GSG2 0.0511317633316248 -EMC6 0.491983958076831 -ATP2A3 0.0644500302496063 -UBE2G1 0.745694457175788 -ZZEF1 0.999923090647574 -GGT6 2.45819064940681e-06 -ANKFY1 0.994632887688137 -ITGAE 7.98813572559606e-13 -PELP1 0.999794752493233 -MYBBP1A 1.69244645255186e-17 -CAMKK1 0.0632390899315781 -P2RX1 6.46551928902605e-08 -C17orf85 0.992974564688454 -SMTNL2 0.00123712384110292 -ALOX15 3.60054517501269e-19 -GLTPD2 0.0259777981808854 -TM4SF5 1.24445437027964e-05 -PLD2 8.12711920535035e-14 -PSMB6 0.143186390069862 -CXCL16 0.043211059537913 -RNF167 0.129414191753804 -MED11 7.54804274594897e-06 -KIF1C 0.470778561371856 -GP1BA 0.0131577164310646 -CHRNE 0.00034790045891714 -SLC25A11 0.666467126614711 -INCA1 8.26123539486397e-09 -ENO3 6.90899000171878e-11 -SPAG7 0.00114719730878394 -ZMYND15 1.43624305354746e-05 -CAMTA2 0.999991613720089 -MINK1 0.999984021507432 -PFN1 0.688581661711059 -VMO1 0.000437154088356555 -ZNF232 0.000435397717293909 -RPAIN 6.3595199382132e-06 -WSCD1 2.91261764619966e-06 -NUP88 4.69521177860175e-06 -NLRP1 2.07780022793946e-12 -PITPNM3 0.999503783305149 -AIPL1 0.000113410667383106 -KIAA0753 3.16922700490618e-19 -RABEP1 0.982815073240194 -ZFP3 0.000584029588192101 -TXNDC17 0.0355158954785338 -MIS12 0.020597647163852 -USP6 1.76208067122363e-18 -SCIMP 0.0125753435020966 -SLC52A1 2.74247658877072e-05 -C1QBP 0.0720502387914283 -DERL2 0.932959932073288 -DHX33 0.0083822781334698 -ZNF594 1.13967591329678e-10 -FAM64A 0.239012864115994 -TEKT1 0.000108974564413063 -C17orf100 0.00377834208828826 -SLC16A11 0.0459183066040548 -RNASEK 0.339227905981652 -SLC13A5 0.353400874150624 -DVL2 0.011361463937534 -ASGR1 0.000452323588660795 -ALOX12 6.34478034828463e-10 -PHF23 0.991271958267002 -FBXO39 0.0250184337777255 -DLG4 0.996592666400884 -ASGR2 6.63907703485809e-06 -CLEC10A 4.25495920863582e-08 -MED31 0.000283388364942475 -C17orf49 0.00762293080428993 -GABARAP 0.670186209633902 -BCL6B 0.151089911885991 -SLC16A13 7.50511260026083e-07 -XAF1 2.07209416294807e-08 -ACADVL 1.31058372898069e-07 -TMEM256-PLSCR3 0.245307294025648 -SPEM1 0.0234530633409911 -EIF5A 0.890876903696708 -CHRNB1 4.33630397665382e-06 -NEURL4 0.999976734381758 -TMEM95 0.00145964978065184 -FGF11 0.0681958357641297 -ELP5 6.47714386783623e-06 -KCTD11 0.447451322334745 -TNK1 8.54608747197239e-05 -GPS2 0.590137501711014 -C17orf74 2.15480274190153e-06 -YBX2 0.968725623233792 -TMEM256 2.94821183080695e-05 -CLDN7 0.0413847351651376 -SLC2A4 0.135386792584163 -ACAP1 0.237755774679294 -NLGN2 0.992624700343966 -CTDNEP1 0.972679931088588 -EIF4A1 0.999614421273252 -WRAP53 0.617463015349294 -SLC35G6 0.000990014878643027 -TNFSF12 0.997954015355093 -SENP3 0.995995419772783 -EFNB3 0.456670731318802 -TNFSF13 0.877768012752006 -SHBG 0.000188842387449784 -DNAH2 2.48851849978906e-21 -POLR2A 0.999999942102154 -FXR2 0.999770109253338 -ZBTB4 0.998490203413562 -SOX15 0.361605911080546 -TNFSF12-TNFSF13 0.997954015355093 -TP53 0.91222295333147 -CD68 0.000599774358695153 -SAT2 0.0176163047684809 -MPDU1 0.144211427826061 -ATP1B2 0.179758869110773 -ALOXE3 2.16324720861559e-13 -TMEM88 0.353473968338177 -CTC1 3.51222906135356e-07 -VAMP2 0.837117600739375 -KCNAB3 6.03305809092679e-12 -KDM6B 0.999994424921105 -HES7 0.7828835695289 -ALOX15B 1.91964555587148e-12 -CHD3 0.999999995517971 -CNTROB 1.23732873376122e-11 -LSMD1 0.00287648469673033 -CYB5D1 4.57519538498037e-05 -GUCY2D 0.000772456643664516 -TMEM107 0.0289055801710133 -PER1 0.875748961589664 -AC129492.6 0.788053355206705 -TRAPPC1 0.227722384643837 -AURKB 0.00588233863615652 -ALOX12B 0.173314447563156 -CCDC42 1.68964027106202e-05 -KRBA2 3.93218978879099e-07 -PIK3R5 0.817693684157708 -PIK3R6 1.37502587799544e-15 -MFSD6L 2.39664500541186e-08 -MYH10 0.999997549727666 -RANGRF 0.0207633298112848 -ODF4 0.000650823794005864 -SPDYE4 0.00122166678944778 -PFAS 2.79097135483484e-08 -ARHGEF15 0.00447718051318209 -USP43 0.00953430437682124 -RPL26 0.915888681432076 -STX8 0.000144082943170255 -SLC25A35 3.54303681221832e-09 -NDEL1 0.979221293391323 -WDR16 4.04605439081288e-11 -MAP2K4 0.997002550124826 -RCVRN 2.96020215900158e-07 -GAS7 0.0255296444534551 -MYH1 1.29393709923033e-29 -DNAH9 1.36586328854305e-35 -DHRS7C 1.11557777202949e-06 -GLP2R 1.03528817609606e-07 -MYH4 8.81492134588241e-35 -ADPRM 0.0655967752653321 -MYH13 1.88615995107426e-29 -MYH3 3.59579597228138e-13 -MYH2 1.37482849584656e-08 -ZNF18 0.000238202477981621 -TMEM220 2.01921640889706e-06 -SCO1 0.507628824320746 -MYH8 1.60588948783826e-34 -PIRT 0.150384795626214 -TEKT3 3.19945204057199e-14 -COX10 0.646572545927849 -HS3ST3B1 0.085454926854491 -ZNF286A 0.0129106053351946 -CDRT15 0.00750643849425516 -AC005358.1 0.866496618990957 -TRIM16 0.000114778734848393 -CDRT4 0.244291013523455 -TVP23C-CDRT4 0.00236229697309959 -TBC1D26 0.86148684441819 -ZSWIM7 0.0879255008426122 -ADORA2B 2.00749888633959e-05 -TVP23C 0.000136737340853385 -PMP22 0.833150051663147 -MYOCD 0.934596479106262 -ELAC2 4.06301820140536e-11 -ARHGAP44 0.999299004436186 -FAM211A 0.732181792462139 -MPRIP 0.870658011638398 -PEMT 0.367752727517099 -MED9 0.315748748937312 -NT5M 3.30164509841504e-05 -CENPV 0.31332786522461 -TTC19 1.05029523664488e-10 -FLCN 0.958489798196264 -RAI1 0.999136111876994 -RASD1 0.0607160204631021 -PLD6 0.0754626037619383 -TRPV2 0.00562915719411862 -PIGL 3.55118862990776e-05 -ZNF624 0.0003058625626781 -TNFRSF13B 6.72184647969379e-13 -NCOR1 0.999999999256818 -ZNF287 0.608657330838459 -UBB 0.620802082419808 -COPS3 0.992904074102341 -EVPLL 2.73060502638625e-08 -ATPAF2 0.00143053764737735 -LGALS9C 0.940115540676897 -SREBF1 0.985657782151979 -TOP3A 2.6363036582595e-08 -SHMT1 1.86116477095909e-07 -ALKBH5 0.803934845862911 -LLGL1 0.977463207224722 -DRG2 0.148077281811429 -ZNF286B 0.00374602908975049 -TRIM16L 0.0168793918042221 -LRRC48 6.08743008535915e-06 -GID4 0.937456357393192 -MIEF2 0.0770145219184436 -TOM1L2 0.414475507742354 -FLII 3.31006863649052e-06 -TBC1D28 1.44444385458443e-05 -SMCR8 0.31942005816427 -PRPSAP2 0.0720452015966568 -ALDH3A2 0.011288383677575 -MFAP4 0.559557121872237 -GRAP 0.21706363500994 -FAM83G 0.0157267816621613 -RNF112 0.0036567395135091 -TVP23B 0.42973287339102 -SLC47A1 1.21582234978014e-09 -ALDH3A1 1.32614029510281e-12 -ULK2 1.30040166627867e-05 -SLC47A2 9.01734392930179e-14 -SLC5A10 3.65971963018288e-12 -B9D1 0.119139655847397 -MAPK7 0.232913565027181 -EPN2 0.177426616638577 -CDRT15L2 0.321628091846862 -AKAP10 0.932283430642292 -KCNJ12 1.42518086932541e-05 -UBBP4 0.0610682954000755 -KSR1 0.609182270949014 -WSB1 0.923194039998769 -RP1-66C13.4 0.0523363020899848 -NOS2 7.26084821392684e-09 -DHRS7B 4.75875090057093e-08 -C17orf103 0.611096491151201 -MAP2K3 0.000496052997398823 -SPECC1 0.109459640243662 -USP22 0.98329279247161 -TMEM11 0.784308456403819 -CCDC144NL 8.14314604314923e-06 -LYRM9 0.0450003073591636 -LGALS9 0.00139053962852711 -ALDOC 0.790720531816382 -NLK 0.998934346648365 -TMEM199 0.000653685320091756 -SARM1 9.18622777225885e-09 -UNC119 0.0097174210089495 -TNFAIP1 0.00736160545150059 -TMEM97 0.0284060151690812 -KIAA0100 0.26524374601424 -IFT20 0.482557826616381 -SPAG5 7.25668525399221e-06 -SDF2 0.682810040021872 -PIGS 0.0799524483019955 -SLC46A1 0.104422521431544 -POLDIP2 0.0492454565267766 -SGK494 2.61343084058986e-05 -SUPT6H 0.999999999889474 -VTN 1.14001465111659e-09 -SLC13A2 8.28516014334455e-07 -FOXN1 0.969497551741561 -PROCA1 0.00087615119311804 -SEZ6 1.39340908360683e-05 -TRAF4 0.840038712273208 -NEK8 1.56481397745759e-06 -RPL23A 0.876904381937284 -TAOK1 0.999999739283145 -TIAF1 0.0263935448212883 -TLCD1 0.0111498745060289 -DHRS13 0.000234050386511642 -ABHD15 0.00179012571573465 -RAB34 4.67974818241862e-06 -FLOT2 0.0172343470815513 -CRYBA1 0.000721666003037628 -TP53I13 0.0627342931396744 -PHF12 0.999959675213551 -FAM222B 0.549446554284703 -PIPOX 9.88251817300836e-11 -GIT1 0.999303229612392 -ERAL1 1.04173456681738e-06 -NUFIP2 0.992086080094595 -MYO18A 0.999417503618365 -SLC6A4 0.85488009451934 -ADAP2 3.98271958834599e-05 -BLMH 0.00956068971702177 -TMIGD1 0.104144558342491 -NF1 0.999999845570262 -GOSR1 0.450937720669574 -CPD 0.247131561049324 -RNF135 0.00307516615505143 -EVI2B 0.177043580614625 -OMG 0.863213191754022 -EFCAB5 7.41783951945302e-16 -CRLF3 0.975928566236353 -CORO6 3.14028875176378e-05 -TBC1D29 8.24847071045149e-05 -EVI2A 8.68889031084954e-06 -NSRP1 0.10480150549491 -ATAD5 0.999999945408971 -SSH2 0.999753484794653 -ANKRD13B 0.970860715744696 -TEFM 0.0433026064919595 -LRRC37B 0.948665375189349 -PSMD11 0.999745808833033 -UTP6 4.82881497097119e-06 -RHOT1 0.955425773125559 -COPRS 0.832459192767082 -RHBDL3 0.00152311404141233 -C17orf75 0.980996282608687 -CCL2 0.667686004742637 -CCL7 0.00926233756877491 -SUZ12 0.999270635842049 -MYO1D 3.30325770821959e-09 -RAB11FIP4 0.993663613309385 -ASIC2 0.989195648597493 -CDK5R1 0.738441122386799 -ZNF207 0.0542638461497623 -TMEM98 0.0286465401329761 -AC003101.1 0.113322436797715 -SPACA3 0.0539629122350744 -RFFL 0.379222205277338 -CCL11 0.0830410038618592 -CCL13 0.0511332837068313 -SLFN5 1.21564626085827e-09 -NLE1 0.0539875179436926 -TMEM132E 2.40150333216285e-05 -FNDC8 1.90285973893222e-05 -C17orf102 0.000161803441056396 -RAD51L3-RFFL 2.2361964935447e-05 -SLFN11 7.42072878105611e-16 -SLFN12 5.03596136268757e-10 -ZNF830 0.447637075601119 -SLFN13 8.74558215982401e-15 -CCL1 0.0630408408804656 -LIG3 2.83467985577354e-06 -SLC35G3 0.0290347473412826 -CCL8 0.052901133609649 -CCT6B 8.8551551033681e-05 -RAD51D 6.18804564528162e-07 -UNC45B 2.76564282824349e-08 -RASL10B 0.0367926151825494 -CCL16 0.092061459649855 -CCL18 0.0103066152116527 -CTB-186H2.3 0.0243603798318569 -C17orf66 5.18584953601546e-10 -TAF15 0.354285877502629 -CCL14 0.000121911835168333 -SLFN12L 2.34689349034419e-05 -AP2B1 0.999667233317167 -CCL3 0.145338664435048 -GAS2L2 0.000457988892081333 -PEX12 3.69624709128407e-12 -CCL5 0.0129094216451699 -MMP28 0.000139259587966798 -RDM1 0.00503096531248961 -CCL15 0.0767077045897299 -CCL23 0.0428120139562607 -LYZL6 7.44688375794253e-05 -C17orf50 0.00795276378704014 -MYO19 2.43129360080767e-18 -TBC1D3C 0.425665089216628 -AATF 1.62332337375335e-07 -C17orf78 0.00407528276770115 -TBC1D3G 0.490002147026831 -CCL4 0.264898889441608 -PIGW 5.93368987083235e-07 -CCL4L1 0.480860804707283 -ZNHIT3 1.21465885857187e-05 -TADA2A 9.66223224552016e-05 -GGNBP2 0.99992911200978 -DHRS11 0.0315613338859281 -CCL4L2 0.489937310110051 -ACACA 0.99999999994361 -MRM1 5.92768053664856e-05 -TBC1D3B 0.636923622994015 -LHX1 0.289265565988382 -MLLT6 0.998762157265753 -CWC25 0.0080101658085688 -HNF1B 0.999286182382324 -PSMB3 0.697590277224645 -GPR179 2.67654454919677e-20 -TBC1D3F 0.620380556789716 -SRCIN1 0.995504290160632 -PIP4K2B 0.989205103584798 -SYNRG 0.97274821167624 -DDX52 1.44174737874652e-10 -DUSP14 0.773652009392439 -MRPL45 0.00150596984840505 -TBC1D3 0.455180214877127 -PCGF2 0.553826743472709 -SOCS7 0.998970598224364 -PPP1R1B 0.082106282395609 -RPL23 0.93162442983743 -PLXDC1 0.000149406289070405 -PGAP3 0.0909847298785156 -STAC2 1.66040366548464e-05 -LASP1 0.8667394350595 -NEUROD2 0.729792595092759 -MIEN1 0.773016772764501 -CACNB1 0.99395962249096 -RPL19 0.974448375215553 -FBXL20 0.998874815002399 -CDK12 0.999991812947639 -PNMT 0.000753820376516649 -ERBB2 0.998894657455293 -C17orf98 0.457750608232201 -FBXO47 0.0140525574075023 -MED1 0.999990934196945 -STARD3 0.149477765017096 -TCAP 0.0757710084804901 -CASC3 0.913674728687448 -THRA 0.167006769731387 -WIPF2 0.366730469469022 -CSF3 0.480555586092398 -GSDMB 1.73303703920524e-07 -MSL1 0.984496890643832 -CDC6 1.81284406664719e-06 -NR1D1 0.946085418280096 -MED24 8.98959437658566e-09 -GJD3 0.00490136828897798 -RAPGEFL1 0.874145903651903 -CTD-2267D19.3 0.344197853968085 -ORMDL3 0.721819207253289 -GSDMA 7.61359631115565e-13 -RARA 0.934197317282478 -IKZF3 0.994921787627197 -ZPBP2 0.00098659399289894 -GRB7 0.000820005745088645 -PSMD3 0.999288334519646 -SMARCE1 0.998188065018721 -KRTAP3-2 0.474662317449609 -KRTAP3-3 0.00478766737481947 -KRT27 8.00950013085285e-14 -KRT40 0.000203216938490707 -TMEM99 3.15417716559819e-05 -TOP2A 0.996224029437404 -KRT24 5.0932770269769e-13 -KRT12 9.44137233590707e-11 -KRT39 8.45580252239315e-09 -IGFBP4 0.236669010399168 -TNS4 0.000130733468322774 -CCR7 0.647008605028774 -KRT23 2.8268268115206e-08 -KRT222 0.00212668208955224 -KRT28 2.06905632889003e-07 -KRT25 1.84752983103555e-06 -KRT20 5.57987712160891e-06 -KRT26 7.22811733131092e-10 -KRT10 0.0200626940208328 -KRTAP4-3 0.000536885200778008 -KRTAP2-3 0.0777171995837597 -KRTAP4-9 0.00150378248703316 -KRTAP4-16P 0.00549629574645564 -KRTAP1-1 0.00844297679609777 -KRTAP1-5 0.00104646254171817 -KRTAP4-6 0.0145001991223108 -KRTAP4-2 0.00502474066236789 -KRTAP1-3 0.653995931200051 -KRTAP4-5 0.0103879610309188 -KRTAP3-1 0.473819461178528 -KRTAP4-12 0.741776468899415 -KRTAP4-4 0.00104159410283142 -KRTAP4-7 1.11232560634725e-05 -KRTAP4-11 0.098639840039914 -KRTAP2-4 0.0863483631962968 -KRTAP4-8 0.00977081898596453 -KRTAP1-4 0.141056283086721 -KRTAP4-1 0.179915848897162 -KRTAP9-9 0.00729870640952065 -KRT35 0.017032337828936 -KRT32 1.20905836070872e-15 -KRTAP9-4 0.000785606510373498 -KRTAP9-3 0.0447129443011167 -KRT33A 2.0406295819065e-11 -KRTAP9-2 0.238025345648846 -KRT33B 2.3968705772229e-06 -KRTAP9-7 0.00547082986165627 -KRTAP9-1 0.00139809073197777 -KRTAP9-6 0.194495477706129 -KRTAP9-8 0.0437541258514207 -KRT38 2.17177355501335e-05 -KRTAP17-1 0.54010776515575 -KRT34 2.61055759222008e-06 -KRT31 0.928538285568948 -KRT37 0.000453720807150653 -KLHL11 0.0534677757011955 -JUP 0.0375345368925628 -KRT9 0.00131873053723034 -FKBP10 0.000807424942436765 -ACLY 0.996414980364678 -LEPREL4 4.37561713844944e-08 -KRT17 7.07353949751571e-06 -KRT36 3.98218636136565e-09 -NT5C3B 7.88066852140565e-05 -KRT16 2.17483656210401e-09 -CNP 0.890888252106868 -KRT19 0.0039364547878244 -KRT15 3.50793987342309e-15 -EIF1 0.764131765089407 -KRT14 0.0673429842229222 -KLHL10 0.931027664206448 -KRT13 0.00166754074952747 -HAP1 1.58556445592013e-19 -GAST 0.00317378388720094 -DNAJC7 0.999727953382784 -TUBG1 0.975922883842582 -PTRF 0.0208810466767636 -ATP6V0A1 0.997249734540438 -STAT5B 0.999953160240961 -STAT3 0.999989193151158 -HSD17B1 0.0560175126865773 -HCRT 0.502440434384708 -GHDC 2.1212473947494e-05 -DHX58 7.28555219955648e-08 -NAGLU 0.000404074411747293 -PSMC3IP 0.00019254510299238 -KCNH4 0.999978751386027 -MLX 0.469292431570312 -FAM134C 0.145899133690528 -HSPB9 5.41472479924188e-05 -RAB5C 0.826569532430599 -NKIRAS2 0.063309457660652 -STAT5A 0.999866029464463 -KAT2A 0.40833206009159 -COASY 1.04516297649836e-07 -AARSD1 2.43909906368394e-07 -EZH1 0.000641437785994428 -COA3 0.00470837762889433 -PTGES3L 0.0247440738776789 -VPS25 0.735077728420435 -TUBG2 0.00431001948765521 -BECN1 0.998697775912791 -PTGES3L-AARSD1 2.56865193172703e-08 -PSME3 0.988103823358922 -CNTNAP1 0.0041087576230276 -RAMP2 0.00389299156111896 -RPL27 0.822384681492307 -CCR10 0.00620605308801029 -CNTD1 0.0218345110656651 -WNK4 1.82873562565171e-13 -AOC3 6.4699578127283e-09 -RUNDC1 0.0189204905991752 -PLEKHH3 0.00376066186801617 -G6PC 0.00181135620983483 -AOC2 5.13940212237188e-10 -PYY 0.0544166347481236 -PPY 0.563418203683469 -NBR1 0.000436706949984189 -CD300LG 0.0299351091325868 -NAGS 4.88883525644423e-05 -RND2 0.000138854210054274 -ARL4D 0.132429775556647 -VAT1 0.0199560134236148 -MEOX1 0.0653974038800068 -MPP3 1.99785500256477e-05 -IFI35 5.69697011611625e-08 -TMEM106A 0.000328022103505525 -DUSP3 0.736744916251957 -SOST 0.379603154764271 -DHX8 0.934509015310341 -MPP2 0.00258050734391977 -ETV4 0.00270290986689264 -BRCA1 3.28742187416399e-20 -CCDC43 0.000257178261367413 -GRN 0.0602784288448183 -ITGA2B 4.07385209926142e-05 -UBTF 0.999998048435118 -SLC4A1 0.909484294882695 -RUNDC3A 0.960334019427912 -G6PC3 1.07483483664146e-05 -C17orf53 5.99401321600703e-08 -LSM12 0.931681763448656 -SLC25A39 0.000102385453221932 -TMUB2 0.00130113933247463 -C17orf104 0.978536144710685 -ASB16 2.42234553349084e-10 -TMEM101 0.161635623953233 -HDAC5 0.999808248473516 -GPATCH8 0.99949548967494 -ATXN7L3 0.955238890019342 -HEXIM1 0.944400234927573 -PLCD3 0.000143297256551118 -KIF18B 8.30836645790731e-05 -DBF4B 4.43213751313207e-08 -GFAP 2.22936756487388e-05 -NMT1 0.998500520689071 -HIGD1B 0.00234558353981055 -CCDC103 0.00218552270508304 -PLEKHM1 0.840543209831517 -GJC1 0.944105282209013 -DCAKD 0.0293860851896359 -ADAM11 0.0247363812211132 -SPATA32 2.95265117999751e-05 -EFTUD2 0.999991435314757 -FMNL1 0.999687036181592 -ARHGAP27 0.00125584382196987 -HEXIM2 0.368236513275247 -ACBD4 1.82643064951694e-05 -MYL4 0.000175624794353708 -SPPL2C 2.29524703916312e-05 -NPEPPS 0.999905920388338 -KANSL1 0.999733505943003 -WNT9B 0.0516168107144711 -GOSR2 0.00028919421780916 -ITGB3 0.141699544644917 -LRRC37A 0.890487355591061 -MAPT 4.68264962282433e-05 -CRHR1 0.792134286397601 -EFCAB13 8.2199210022743e-19 -KPNB1 0.999994327501246 -CDC27 0.486673202422918 -NSF 0.713682130183303 -STH 0.00444466614164462 -RPRML 0.421294822682809 -WNT3 0.946108101336536 -MRPL10 0.288891351405341 -SCRN2 6.55878589036845e-07 -NFE2L1 0.998123949191488 -HOXB3 0.610993265044198 -LRRC46 0.000135433194771157 -COPZ2 0.0017094888551626 -PNPO 3.71896087830709e-05 -HOXB2 0.00183830846418713 -SP2 0.969394324989432 -TBX21 0.963242650804377 -SNX11 3.85654523915294e-05 -CDK5RAP3 2.8653949299435e-12 -CBX1 0.949842677925257 -OSBPL7 0.181605380199765 -HOXB1 0.115199709546097 -HOXB4 0.119746209572469 -PRR15L 0.481246950810061 -TBKBP1 0.0383777655190971 -SKAP1 0.000301840236150372 -SP6 0.0229475656346052 -GNGT2 0.173047625856269 -B4GALNT2 9.64033158743695e-07 -PRAC1 0.00177992300773383 -HOXB13 0.00987475094591023 -HOXB6 0.00958340713523565 -TTLL6 7.4885844910963e-08 -SNF8 0.290873868173922 -UBE2Z 0.927558729836687 -HOXB8 0.444768417534794 -GIP 0.162839345434596 -PHOSPHO1 0.631109187622191 -HOXB7 0.00759639061323712 -ATP5G1 0.327525828609274 -ABI3 0.0277110067491567 -HOXB9 0.101637476227325 -CALCOCO2 0.0317624526733932 -IGF2BP1 0.998573996721702 -HOXB5 0.481440388121452 -ZNF652 0.970739626335692 -EME1 7.06666940107235e-11 -MRPL27 0.385344633134836 -XYLT2 0.337133945483576 -PPP1R9B 0.997286913740502 -SLC35B1 0.0132862685940911 -SGCA 0.194446674101566 -FAM117A 1.21995888453457e-05 -PHB 0.821632149771825 -NXPH3 0.793272419563662 -PDK2 0.168975524516492 -TAC4 0.0419589061072124 -SAMD14 0.0202644303517086 -DLX3 0.0113653471173306 -ITGA3 2.40911978006841e-05 -KAT7 0.999956770504954 -COL1A1 0.999999998983348 -SPOP 0.992531222874917 -NGFR 0.238222215108748 -TMEM92 0.129143042311778 -DLX4 0.00519723009622915 -WFIKKN2 0.025878487775655 -NME1-NME2 0.010430774313355 -NME1 0.00777448651598859 -SPATA20 1.10605452840792e-05 -ANKRD40 0.313648021576856 -CHAD 0.0337024141100405 -CA10 0.973117501696163 -ACSF2 0.0838516397148764 -TOB1 0.798204384419713 -LRRC59 0.482144865133273 -NME2 0.010430774313355 -RSAD1 5.75080843134765e-06 -SPAG9 0.999998937733062 -EPN3 1.33458182552155e-09 -LUC7L3 0.999974250781125 -MYCBPAP 0.00173300584771018 -CACNA1G 0.999996517362333 -ABCC3 2.61612974200613e-14 -UTP18 0.415444933293643 -MBTD1 0.995179972273057 -DGKE 0.000684088440351919 -PCTP 1.63044512468483e-05 -HLF 0.87786179819329 -COX11 0.402262800633254 -COIL 0.0156002339592544 -TOM1L1 0.00293414695871849 -C17orf67 2.47630048065969e-05 -KIF2B 3.73383408114166e-15 -ANKFN1 4.03101640243908e-06 -NOG 0.682857447957634 -STXBP4 1.41709360491401e-14 -MMD 0.0136446548070045 -SCPEP1 6.98627530887446e-08 -TMEM100 0.485334011918092 -TRIM25 0.135290442283726 -AKAP1 0.561768712699788 -MSI2 0.963858041525188 -LPO 2.90912911352746e-11 -SRSF1 0.991994022925919 -BZRAP1 0.0566264084919234 -MRPS23 0.0494860578184962 -EPX 6.21196893270215e-10 -OR4D1 0.000295713706769417 -MPO 1.74837167117931e-09 -DYNLL2 0.687802227346452 -HSF5 0.741540032327461 -VEZF1 0.943031802518397 -MTMR4 0.997305474235374 -CUEDC1 6.38268720532172e-05 -C17orf47 1.30236935252049e-05 -SUPT4H1 0.338447260034668 -RNF43 0.324237751943356 -SEPT4 0.0118368603873699 -TEX14 6.67135466367958e-23 -OR4D2 0.0138443702712982 -MKS1 3.9743813098665e-09 -RAD51C 4.27808774468152e-09 -CA4 0.0108088499819045 -USP32 0.999999997115398 -HEATR6 4.94357747313783e-10 -TRIM37 0.172389368264362 -PTRH2 0.336972394236785 -SMG8 0.0219391466927345 -CLTC 0.99999999331335 -VMP1 0.930655518495749 -YPEL2 0.928981263851905 -PPM1E 0.973416928914191 -APPBP2 0.99907128300278 -SKA2 0.000501074471856632 -DHX40 0.996354246510063 -RNFT1 0.011205655064819 -TUBD1 0.000375248305025868 -RPS6KB1 0.998223240008685 -C17orf64 0.0138040924538792 -GDPD1 0.00337916957867071 -PRR11 3.71709922242414e-06 -ACE 4.63282874453648e-18 -BCAS3 0.998848201672345 -CYB561 0.698896026820601 -MRC2 0.985888157648222 -MED13 0.999999999944093 -DCAF7 0.875048579312607 -MARCH10 3.44665140099752e-16 -BRIP1 5.37815596396534e-13 -NACA2 0.0989262820990375 -TANC2 0.99999996584406 -EFCAB3 0.000159092434528578 -RP11-15E18.4 0.120162533312661 -PPM1D 0.00116800419611814 -KCNH6 3.93932913677419e-17 -INTS2 0.999806217287338 -TBX4 0.407057023157267 -METTL2A 1.7733777443887e-05 -TLK2 0.999999805897045 -TBX2 0.964019296564926 -C17orf82 7.35000906630045e-05 -TEX2 0.440979879688037 -GH1 0.0174315619078563 -PSMC5 0.969571425390585 -DDX42 0.999995783745318 -CCDC47 0.00258817681450808 -SCN4A 0.0104419346692469 -LIMD2 0.0176301694774636 -ERN1 0.91361398180331 -CD79B 0.950002656747314 -TACO1 0.357585528083816 -CSH1 0.741138849069797 -STRADA 0.0020153912770355 -CSHL1 0.000458792773342202 -SMARCD2 0.980738446599835 -CSH2 0.458223920935805 -FTSJ3 0.484157751981298 -GH2 3.38589979948727e-05 -ICAM2 0.0232669387159647 -MAP3K3 0.999526986907979 -APOH 1.28717988796445e-10 -PSMD12 0.997267742152841 -BPTF 0.999999999995241 -PITPNC1 0.967498710994397 -AXIN2 0.119052193328808 -NOL11 0.0278293532112974 -CACNG1 4.77504657244384e-07 -C17orf58 0.0821564161266073 -POLG2 2.159642523574e-06 -CACNG4 0.21577447263925 -GNA13 0.533516375005495 -DDX5 0.99745409892001 -SMURF2 0.999989890654782 -CEP95 9.43885980506812e-12 -HELZ 0.999999999965185 -CACNG5 0.0535604442272795 -RGS9 2.03911077308728e-10 -CEP112 3.05841247613028e-18 -PRKCA 0.952135908118796 -ARSG 1.55401104160652e-05 -SOX9 0.983539902653989 -ABCA5 2.52772496034416e-15 -FAM20A 0.00250112243343209 -ABCA10 1.20688643660446e-27 -ABCA8 1.71937025604407e-33 -WIPI1 0.523500460994852 -PRKAR1A 0.999223269468243 -SLC16A6 0.205129420734742 -AC079210.1 0.0365450820501632 -KCNJ2 0.820229027644725 -ABCA6 1.83135791674863e-16 -MAP2K6 0.951049683729579 -AMZ2 1.54653236502662e-08 -KCNJ16 5.41974671317498e-06 -SSTR2 0.235751811356346 -SLC39A11 7.77832608077154e-05 -KPNA2 0.728640006952611 -ABCA9 1.27777342298461e-26 -C17orf77 0.00124631276721521 -CD300A 8.94314660641978e-07 -CD300LD 0.0462193913168544 -GPR142 5.59549133508041e-05 -C17orf80 2.53809595414424e-07 -COG1 0.10252799642341 -GPRC5C 0.0055136074174967 -CD300LB 0.000639117802263442 -CDC42EP4 0.0975901833443728 -SDK2 0.0290344313872634 -TTYH2 0.347961542462659 -FAM104A 0.612044064845623 -RPL38 0.890753137672675 -CD300E 0.0804606661426047 -KIF19 5.3712342427336e-13 -CD300C 0.000578295782438879 -AC103809.2 0.2068861193725 -BTBD17 0.0108349364889999 -DNAI2 4.56806643361888e-11 -RAB37 8.22692114813263e-05 -OTOP3 9.57033698502344e-06 -ICT1 0.0193427333396564 -FADS6 2.48053373843411e-07 -SLC16A5 3.7061944576566e-05 -ATP5H 0.0108715653767665 -ARMC7 0.0149468934826879 -TMEM104 2.89327933186764e-05 -HID1 0.465505319637047 -HN1 0.0193134506649175 -CD300LF 4.96998888405705e-06 -CDR2L 0.00132717884607588 -KCTD2 0.0618999883050334 -GRIN2C 0.00393764821854446 -FDXR 0.000894955007086674 -NAT9 0.0806611770519349 -OTOP2 3.08382306848341e-09 -NT5C 0.0126488300759267 -USH1G 0.00108621943329599 -SLC9A3R1 6.3597388529883e-05 -GALK1 0.000940520588108951 -NUP85 0.999782631941592 -LLGL2 8.27305979414576e-07 -SAP30BP 1.57392044285554e-05 -SUMO2 0.850515883834874 -MRPS7 0.00249161801672261 -GRB2 0.549680745843086 -MIF4GD 3.58018633061673e-05 -UNC13D 2.52003157333038e-12 -CASKIN2 0.999986554679267 -TSEN54 1.75671632095305e-05 -KIAA0195 1.59176764794571e-07 -UNK 0.994321108472501 -SLC25A19 0.929610775752259 -H3F3B 0.809724779677426 -GGA3 0.505243695718199 -ITGB4 1.05348780207872e-11 -RECQL5 3.00939600505428e-07 -UBE2O 0.999985318208959 -EXOC7 0.000651392901677263 -ZACN 1.96181645761295e-15 -CDK3 0.000751722980772095 -FBF1 1.13971483330464e-19 -TRIM47 0.321925207559748 -MRPL38 4.08583632282511e-06 -WBP2 0.089618232806846 -PRPSAP1 1.9694174251285e-10 -UBALD2 0.262586852012457 -ACOX1 0.0944353057008641 -EVPL 6.48709103471533e-14 -QRICH2 1.21935180720808e-18 -TRIM65 2.48168761970087e-09 -SPHK1 1.29152628928557e-05 -GALR2 0.00797093656746506 -SRP68 0.36504497260724 -RNF157 0.000108022535284771 -FOXJ1 0.826867383152592 -METTL23 0.113237609183132 -TMC8 5.57197204809154e-12 -JMJD6 0.821640917971612 -TMC6 5.0774933274282e-08 -ST6GALNAC1 2.24205320873445e-11 -MFSD11 0.0045322819249491 -TNRC6C 0.999997823984353 -SYNGR2 0.000588831651132254 -ST6GALNAC2 4.43095165859324e-08 -MGAT5B 0.126104149453102 -MXRA7 0.013741641700292 -SRSF2 0.352601171847882 -SEPT9 0.892006145895558 -PRCD 0.00310509622416 -AANAT 0.0130382386829393 -SEC14L1 0.179640443143628 -RHBDF2 0.000966720943739994 -CYGB 0.234616769536826 -C1QTNF1 7.24017785005128e-05 -BIRC5 0.215847836777704 -USP36 0.0685526746674987 -DNAH17-AS1 0.446203082126616 -SOCS3 0.576558158731858 -CANT1 0.00290923611890276 -TIMP2 0.526868279273317 -AC087645.1 0.215475788115553 -ENPP7 2.20917341359956e-10 -CYTH1 0.994541234354466 -TK1 0.255670113108694 -AFMID 0.0021381282329124 -PGS1 0.000957081939012816 -LGALS3BP 3.92643319809695e-07 -ENGASE 8.06055418663565e-21 -SLC26A11 4.10510695836507e-10 -CBX8 0.994625905090376 -RNF213 1.67778352788526e-29 -ENTHD2 0.000515475663107338 -NPTX1 0.426444496739896 -CCDC40 6.32159262183706e-11 -CBX2 0.954823918488159 -AZI1 5.08817766356591e-08 -ENDOV 2.6283345911486e-06 -GAA 4.62006515849408e-11 -TBC1D16 0.00619825659275789 -CBX4 0.381198481678265 -BAIAP2 0.464202488604374 -CARD14 3.14969356207765e-14 -RPTOR 0.999999983261949 -CHMP6 0.765888301098665 -SGSH 0.000105789945939708 -AATK 0.806763652251614 -EIF4A3 0.998989654876332 -SLC25A10 0.00243936812560947 -ACTG1 0.218555803598304 -NPLOC4 0.998697457532177 -GCGR 0.452713871338603 -C17orf89 0.372022649415276 -TMEM105 0.0116196090073997 -RP11-1055B8.7 0.996309984300158 -HGS 0.131424768706374 -PPP1R27 0.00195516228605964 -C17orf70 0.0882581171699184 -MRPL12 0.0501971389457513 -FSCN2 9.45740737766919e-09 -CCDC137 0.0001014857442089 -OXLD1 0.0414232246772906 -PDE6G 0.014216424092894 -FAM195B 0.317596823645591 -TSPAN10 7.87266607064108e-07 -ARL16 0.0215720542657569 -SLC38A10 4.09242180982345e-08 -NOTUM 0.000860399771955871 -DUS1L 1.5346357409002e-06 -ARHGDIA 0.727995864276251 -RAC3 0.0354422485411882 -PYCR1 0.000359028805830681 -SIRT7 0.567108371695204 -MAFG 0.625915690848724 -NPB 0.428299526299304 -FASN 0.99999995015986 -ALYREF 0.831865499534863 -STRA13 0.591966927176029 -LRRC45 3.1506860909144e-06 -GPS1 0.98465745647653 -DCXR 3.46544861989814e-05 -RFNG 5.67670625784945e-08 -ASPSCR1 6.0743019973141e-08 -P4HB 0.968508654303976 -PCYT2 0.248194491721239 -ANAPC11 0.192592194411128 -CD7 0.445277573901799 -C17orf62 0.00095506373303246 -TBCD 6.98438545881523e-05 -CSNK1D 0.991910743527009 -FN3KRP 3.65777484277493e-07 -CCDC57 2.63627612154765e-13 -OGFOD3 0.000595568731470111 -SLC16A3 0.325132712059301 -NARF 0.00122491910128246 -RAB40B 0.00383601041524839 -FOXK2 0.918748433171859 -FN3K 1.64310323001164e-05 -UTS2R 1.80188717092643e-05 -ZNF750 0.865734363838442 -SECTM1 0.172404202643393 -TEX19 0.000184450309866715 -B3GNTL1 2.14222358700744e-11 -HEXDC 1.58767542915452e-06 -WDR45B 0.637042299010321 -METRNL 0.860216826347564 -EMILIN2 1.59772922427617e-09 -COLEC12 0.991466232637133 -USP14 0.927536807900908 -MYL12A 0.00150150767485969 -METTL4 2.54716995117714e-05 -LPIN2 0.673512974845848 -CLUL1 3.21487861579903e-06 -CETN1 0.531422796741771 -SMCHD1 0.999999998790609 -YES1 0.0463916223696272 -TYMS 0.924544533248258 -ADCYAP1 0.133462668533983 -MYOM1 1.077002599654e-21 -NDC80 0.00148617426184344 -TGIF1 0.0907591522452098 -THOC1 0.871670074938969 -RP11-683L23.1 0.00833262578272861 -ENOSF1 1.26226997891008e-10 -C18orf56 0.186096885978689 -MYL12B 0.290511998767659 -EPB41L3 0.0292783880452307 -DLGAP1 0.993045514283556 -RAB31 0.0540334843531379 -PTPRM 0.999958213992023 -L3MBTL4 4.20004377573476e-08 -RALBP1 0.670181325366825 -ANKRD12 0.999985243734791 -PPP4R1 0.998557751833321 -LAMA1 1.39176131837658e-24 -SOGA2 0.00589096940992293 -LRRC30 2.18765652608836e-08 -TXNDC2 2.94038807435751e-07 -RAB12 0.718356946973086 -NDUFV2 0.00763022340313864 -ZBTB14 0.628505782225752 -TWSG1 0.890252416255217 -ARHGAP28 0.0029584189440561 -CEP192 7.43868591651398e-10 -VAPA 0.123795283054545 -IMPA2 0.237822649061139 -SLMO1 1.94867490561801e-07 -APCDD1 0.000654607968648686 -PSMG2 0.00355676049077914 -CHMP1B 0.682019462509046 -CIDEA 0.0146284389438315 -SPIRE1 0.330091752046804 -GNAL 0.987372719895044 -CEP76 0.0188226507122001 -PIEZO2 0.603955312622787 -PTPN2 0.995606482600094 -TUBB6 0.000511267490944529 -ANKRD62 0.458132580584637 -MPPE1 8.3419136485111e-06 -SEH1L 0.745892347230499 -NAPG 0.0861319351364347 -AFG3L2 0.0147221162102033 -ESCO1 0.998809460698957 -TMEM241 7.76288053512061e-05 -CABLES1 0.445044394222778 -MIB1 1.00071804997675e-44 -MC2R 0.0574474574260785 -RNMT 0.0809328060183284 -POTEC 0.161704413964799 -ROCK1 0.999996548070552 -LDLRAD4 0.377306395292768 -RBBP8 0.000108378971563585 -MC5R 0.00108831422696949 -ZNF519 8.85353913956773e-07 -FAM210A 0.0151243026401628 -ANKRD30B 1.4946934567636e-09 -CTAGE1 2.09542255826793e-06 -ABHD3 1.33741470632214e-06 -SNRPD1 0.847045312877468 -PSMA8 0.00397964772969195 -HRH4 1.67289121238146e-07 -OSBPL1A 4.1067927420582e-05 -DSC3 5.45072408048126e-20 -TAF4B 0.879312141538273 -TTC39C 0.0146468612556312 -IMPACT 3.31631338303807e-05 -LAMA3 4.40816622681492e-24 -RIOK3 0.000146775088539085 -CHST9 5.84291419980849e-07 -C18orf8 0.999882357316615 -CDH2 0.897440931236462 -AQP4 0.0181490424325557 -KCTD1 0.934855730655081 -DSC2 0.000683301516097171 -NPC1 0.000213375031005479 -CABYR 0.000210501288958305 -ANKRD29 2.59982243312639e-05 -SS18 0.994140958944221 -ZNF521 0.999979350698415 -DSG4 6.32076861880848e-05 -CCDC178 4.11143333531655e-29 -MEP1B 6.31312023820361e-21 -GAREM 0.827971733794348 -ASXL3 0.999977048473461 -DSG3 3.35935663514832e-13 -KLHL14 0.0827221887035056 -NOL4 0.998788438158561 -RNF138 0.738927914381854 -TTR 0.130835841006919 -AC012123.1 0.115697430160591 -DSG1 0.979103460229869 -DSG2 0.000747066619496092 -TRAPPC8 0.999999744151836 -DTNA 0.921398185265569 -B4GALT6 0.995466887687435 -DSC1 4.38539889001518e-08 -MAPRE2 0.96964473730636 -RNF125 0.0806248454194983 -SLC25A52 0.00585592728276631 -SETBP1 0.999002929381036 -KIAA1328 6.0725380486659e-05 -SLC39A6 0.000761849565836676 -PIK3C3 0.0803177256175585 -RIT2 0.0600485284509002 -ZNF24 0.995634782887564 -RP11-322E11.6 0.0138196095420666 -SYT4 0.12760475421924 -CELF4 0.974364730195216 -RPRD1A 0.25114910852473 -FHOD3 0.997517122779082 -ZNF397 0.00104846294119933 -ZSCAN30 9.21737680032271e-09 -ZNF396 4.72222820428313e-07 -TPGS2 0.000133031926461961 -GALNT1 0.742968960381217 -ELP2 1.30720183321891e-07 -MOCOS 6.10346244046287e-07 -C18orf21 0.00277151818065711 -INO80C 0.000502408928799958 -IER3IP1 0.0184346889412637 -SKOR2 0.611171343025554 -SLC14A2 8.427413552635e-14 -TCEB3B 1.80367559188731e-08 -KATNAL2 0.000125861969085373 -ATP5A1 0.998862483879488 -RNF165 0.971099075288373 -PSTPIP2 0.107611557288659 -HAUS1 0.000296742662155892 -PIAS2 0.997942260674644 -SLC14A1 1.90357446794666e-09 -SIGLEC15 1.08177312684363e-11 -ST8SIA5 0.0183928498018628 -EPG5 6.93636539718872e-07 -HDHD2 0.000427885483918572 -C18orf25 0.901996340401965 -SKA1 1.32265949651803e-06 -CXXC1 0.99786210530366 -ZBTB7C 0.907221460237709 -SMAD7 0.975695730781462 -ELAC1 0.895039746012204 -RPL17-C18orf32 0.605942171595584 -MYO5B 5.4231747689238e-10 -CTIF 0.982754580423637 -MRO 0.000178042221372106 -MAPK4 0.319051500545285 -SMAD2 0.988180754171779 -RPL17 0.494059426420399 -C18orf32 0.18275268888643 -ME2 1.17412339312961e-07 -DYM 5.18111501130597e-09 -CCDC11 1.5987996365213e-13 -ACAA2 0.0035080415350425 -MBD1 0.959615951476631 -LIPG 8.35570265503166e-05 -TXNL1 0.956025974452741 -BOD1L2 0.510146461496365 -STARD6 0.0263351617026343 -RAB27B 0.687300099985693 -WDR7 0.999999983540482 -MBD2 0.989310018452397 -ONECUT2 0.903998414160395 -C18orf54 6.01291582416808e-06 -DCC 0.99999895681268 -MEX3C 0.946417957993422 -TCF4 0.999866544499818 -DYNAP 0.409402930300484 -FECH 0.138946552569902 -SMAD4 0.967432535938662 -POLI 4.26967456461878e-09 -ATP8B1 3.6650370597666e-07 -ST8SIA3 0.963677659153812 -NARS 3.48085840763395e-07 -NEDD4L 0.999966646256687 -CCDC68 6.41317549868977e-07 -GRP 2.14419491039997e-06 -KIAA1468 0.999999559987516 -MC4R 1.53624620586494e-05 -RNF152 0.00705384647515106 -SEC11C 0.694287699372018 -CCBE1 1.66521605518147e-06 -MALT1 0.994144577983795 -CPLX4 0.00218941569433162 -RAX 0.841214635572597 -ZNF532 0.905138239772125 -ZCCHC2 0.305659357295976 -ALPK2 3.561471165346e-13 -CDH20 0.980513136445033 -PMAIP1 0.461950506283966 -AC015989.2 0.0948579293005935 -PHLPP1 0.918153757180465 -BCL2 0.337855763889345 -PIGN 9.02060283775279e-16 -TNFRSF11A 0.87991735395021 -LMAN1 0.486069838864669 -SERPINB2 5.7582951955992e-05 -CDH7 0.763007122581869 -DOK6 0.458839966900032 -SERPINB7 7.67027798018844e-05 -SERPINB8 6.74035819292039e-07 -SERPINB5 0.450309366949428 -SERPINB11 5.09314823816963e-07 -DSEL 5.16087410257055e-06 -SERPINB12 7.75579414319893e-17 -KDSR 0.472000395094808 -HMSD 0.0023239519442082 -CCDC102B 3.31193608462394e-09 -VPS4B 0.21387385685724 -SERPINB13 0.000102298767913382 -SERPINB4 1.27619533633833e-11 -SERPINB3 8.68913370901801e-14 -SERPINB10 6.26724483578838e-05 -CDH19 1.92476251537999e-09 -TMX3 0.191322508256436 -CYB5A 0.0337393159429441 -CNDP1 1.90969167167883e-05 -TIMM21 0.00532093086929824 -CNDP2 0.00119100825592748 -ZADH2 0.000446821227839176 -RTTN 2.40394270810394e-13 -CD226 0.505154014855792 -RP11-321M21.3 0.0992216727380532 -SOCS6 0.879897418286163 -ZNF407 0.999995919065608 -CBLN2 0.318302604444597 -NETO1 0.949402709104517 -TSHZ1 0.939559480233567 -FAM69C 0.016640101426451 -FBXO15 0.0274701773773479 -GALR1 0.000193369133207075 -NFATC1 0.969219887746034 -CTDP1 0.924155318985366 -SALL3 0.0901931288456932 -PQLC1 0.000252469088329691 -MBP 0.568470953651191 -KCNG2 0.00583161969703067 -RBFA 0.000358068013612274 -ZNF236 0.999998363501894 -ZNF516 0.26883020897488 -ATP9B 7.02414710042202e-12 -SMIM21 0.000512613526087449 -ADNP2 0.346937920967371 -TXNL4A 0.00154673666437753 -PARD6G 0.111935410098095 -MADCAM1 0.428374924492615 -ODF3L2 0.00314258776622615 -THEG 4.92698073399521e-07 -CDC34 0.56046297683146 -MIER2 0.977262862888772 -FSTL3 0.418831972518919 -POLRMT 2.5979329788051e-13 -OR4F17 0.505111518356241 -PPAP2C 0.00286074472408096 -SHC2 1.22486237905385e-05 -PALM 0.393531038933643 -GZMM 0.00121003300542887 -MISP 1.94870607708529e-10 -HCN2 0.832343161848257 -FGF22 0.000103153895712467 -PRSS57 1.72723245472858e-07 -RNF126 0.774554603279982 -TPGS1 0.00346749464860698 -BSG 0.0573043629421646 -GRIN3B 0.00111371164374087 -PTBP1 0.998739199526157 -KISS1R 0.00397107374528621 -PRTN3 0.000831488795975963 -POLR2E 4.40648501422082e-08 -GPX4 0.0173298887825943 -WDR18 0.901607559974541 -MED16 0.0187661183097687 -SBNO2 0.0244237651687452 -R3HDM4 0.0193453111593238 -CFD 0.0195668736380904 -LPPR3 0.0562793079796428 -TMEM259 0.899319773250088 -ELANE 0.767207228111322 -ABCA7 1.89160398990449e-36 -AZU1 8.74467686278012e-05 -STK11 0.978282902427481 -ARID3A 0.425084301076406 -CNN2 0.212309400922857 -HMHA1 0.453633762319863 -RPS15 0.697325164941198 -ADAMTSL5 3.22271116895574e-10 -C19orf25 0.0343632220806308 -MBD3 0.919323880451979 -ATP5D 0.00118323811959957 -C19orf26 0.00372342728639336 -NDUFS7 0.750835828529347 -GAMT 2.64994350917261e-05 -PLK5 0.0716254602582295 -MIDN 0.0490626513742138 -REEP6 0.000463081508958989 -DAZAP1 0.999571003507893 -CIRBP 0.622585655314118 -APC2 0.999980518341102 -EFNA2 0.376749730846869 -PCSK4 6.59246485167205e-13 -MUM1 0.032092632530893 -UQCR11 0.0305034614325173 -DOT1L 0.999988961757209 -ABHD17A 0.0505568745094196 -TCF3 0.185647143501164 -REXO1 0.567927564385063 -JSRP1 8.90273527204223e-10 -OAZ1 0.0889951573895078 -KLF16 0.473218601321024 -ATP8B3 9.18832885175999e-22 -AMH 4.8954693456369e-05 -CSNK1G2 0.923449277236984 -SCAMP4 0.0209517140380353 -PLEKHJ1 0.463248129638187 -BTBD2 0.98767894213597 -ADAT3 0.0011796465942971 -MOB3A 0.002927403350296 -AP3D1 0.798002533603789 -MKNK2 9.33657569741937e-06 -SF3A2 0.774375362030151 -IZUMO4 4.69904233416224e-08 -ZNF77 4.31245286065236e-13 -ZNF554 4.61366216735965e-06 -SGTA 0.470281213257638 -GNG7 0.475557140257132 -TLE2 0.000766444994989725 -LMNB2 0.995599596829826 -TMPRSS9 1.76797143257435e-18 -GADD45B 0.185427441870799 -LSM7 0.281731306604913 -ZNF556 1.57972888888797e-05 -SLC39A3 0.0608464544153053 -ZNF57 1.0043121865806e-06 -C19orf35 0.00635456730822442 -DIRAS1 0.62334167137764 -THOP1 0.0234920934710946 -TLE6 0.00101145755365688 -TIMM13 0.309091873509944 -ZNF555 1.74413607005712e-09 -AES 0.650716677191199 -TJP3 2.20425161433974e-21 -FZR1 0.99794752523794 -GNA11 0.966183014336431 -MFSD12 1.07410212559189e-09 -NCLN 0.509474338262742 -GIPC3 0.0542521307918308 -RAX2 0.510132428611179 -TBXA2R 0.113768130952393 -CELF5 0.996405707329076 -HMG20B 0.342236180884619 -DOHH 0.0201020241741167 -MRPL54 0.0856958675435356 -S1PR4 0.520047224467617 -APBA3 2.11553616288552e-11 -PIP5K1C 0.859389818234551 -GNA15 0.306963811881902 -NFIC 0.842498930517079 -CACTIN 0.999345095775966 -FSD1 0.732578210899087 -STAP2 1.62685084919042e-13 -ZFR2 5.37163859231556e-09 -MPND 0.0157249668320667 -DAPK3 0.0611344951968641 -EEF2 0.994520586206042 -EBI3 0.0195996499684184 -ANKRD24 1.87439154445724e-06 -NMRK2 1.16630399616328e-07 -MAP2K2 0.86326115931858 -PIAS4 0.994350817581458 -CCDC94 0.00096047083699541 -ATCAY 0.0874733261874534 -SHD 5.1849696454898e-06 -TMIGD2 0.0152518701509106 -MATK 0.000234672612755097 -SIRT6 0.0544711567553148 -CREB3L3 1.58659746321972e-09 -SEMA6B 0.742578966540981 -PLIN3 1.2373923055107e-08 -TICAM1 0.852477311306477 -DPP9 0.999114700689224 -PLIN5 1.3236836849853e-07 -PLIN4 1.65846988023811e-12 -KDM4B 0.999934757141383 -C19orf10 5.62643557499367e-05 -SAFB2 0.999582500881394 -TNFAIP8L1 0.463548116687416 -UBXN6 0.0473268975427938 -LRG1 3.42349504526834e-05 -HDGFRP2 0.892854120091016 -SAFB 0.999685074218684 -SH3GL1 0.0586367540123022 -PTPRS 0.760915060454347 -ZNRF4 0.263224270273744 -CHAF1A 0.996226225687986 -ARRDC5 1.97507105170421e-06 -RANBP3 0.999905044102182 -FUT6 0.0221299532408796 -C19orf70 0.0159221835622921 -RPL36 0.623121945323737 -NDUFA11 0.538189295082718 -VMAC 0.0234647088154216 -MLLT1 0.991457207548845 -ACER1 0.335356707410971 -FUT5 0.00235788381432205 -CAPS 5.18362462737594e-07 -PRR22 0.0206405591402269 -DUS3L 2.44680259980273e-09 -CLPP 0.587942370870824 -FUT3 0.373828733490639 -NRTN 0.100149118623238 -LONP1 0.999697932788122 -RFX2 0.989509333059145 -ACSBG2 3.48441388003295e-07 -HSD11B1L 0.00169630641794967 -CATSPERD 1.06714268717347e-08 -SH2D3A 4.11388010763311e-06 -VAV1 0.999993062871965 -PSPN 0.00774141151421535 -CRB3 0.369971428667681 -CD70 0.045752208268171 -GPR108 1.69455789377898e-08 -EMR1 5.77895323440831e-14 -TNFSF14 0.813514842794245 -GTF2F1 0.0287352714286824 -TNFSF9 0.0968268555510867 -TUBB4A 0.00305566312177654 -ALKBH7 2.76251331581087e-06 -TRIP10 0.354472308235879 -SLC25A23 0.0760416946192497 -SLC25A41 5.97614676962731e-05 -C3 0.999590151258431 -KHSRP 0.99971122153684 -DENND1C 0.0360059989669383 -PEX11G 0.000252773182205477 -PNPLA6 1.58991551414988e-08 -ZNF557 1.50769654048194e-06 -MCOLN1 0.0370559727759663 -ZNF358 0.867025329554356 -ARHGEF18 0.90836751633667 -MBD3L3 0.208438985597134 -RETN 0.0740027903756986 -CAMSAP3 0.999943968611488 -PCP2 1.2765672414005e-05 -TRAPPC5 0.577704358866904 -INSR 0.186547844102196 -C19orf45 2.71015896406554e-15 -STXBP2 7.76317734429722e-05 -C19orf59 0.00958136392473751 -XAB2 0.997070259537138 -FCER2 1.50208228042754e-09 -CCL25 0.169939684464423 -CD320 0.0599265597352726 -RPS28 0.688845091552417 -ELAVL1 0.959986603851889 -CLEC4M 3.08704615217908e-05 -TIMM44 0.818201941811417 -AC010336.1 4.28316963730128e-05 -SNAPC2 0.10316814001529 -LRRC8E 0.000781502371027772 -NDUFA7 0.00402195717519935 -CLEC4G 0.00112276684554795 -EVI5L 0.989107012846773 -FBN3 1.35475416104555e-27 -CD209 2.95624746711489e-08 -CERS4 2.04162899798769e-13 -MAP2K7 0.985719994203379 -CTXN1 0.10505738095457 -ANGPTL4 9.46497214192654e-09 -ZNF317 0.0157065703255095 -OR7G3 0.405963699611883 -HNRNPM 0.999948048705257 -ZNF414 0.00274920575712607 -MARCH2 0.246993249094028 -OR2Z1 1.26516520297013e-08 -OR7G1 0.0757166763743766 -OR7D2 0.0925271219188337 -MYO1F 0.158022191479258 -RAB11B 0.664363642569307 -OR7G2 0.00709376609761956 -MBD3L1 1.30309193734163e-05 -ACTL9 0.042627929021418 -KANK3 8.53381795135144e-06 -PRAM1 0.00762489575795408 -ZNF558 0.000767127294544923 -OR1M1 0.000183470437180503 -ADAMTS10 0.980346240233128 -ZNF846 3.7497661971544e-16 -OLFM2 0.964592021100157 -OR7E24 0.298717571187412 -ZNF560 7.36420867683153e-10 -PIN1 0.340906808984076 -UBL5 0.080158330255147 -FBXL12 0.0145183376555761 -ZNF121 0.72485940087732 -ZNF561 0.00976254715762805 -RDH8 3.72790127743868e-05 -ZNF699 1.56585740737052e-07 -OR7D4 8.94371114921136e-06 -ZNF812 5.99970209545536e-07 -ZNF266 1.25383025237533e-09 -ZNF426 5.94845054621104e-13 -ZNF562 0.139679896104799 -ZNF559 7.71788505951748e-09 -COL5A3 7.11903366992312e-07 -ZNF177 5.54015130310773e-06 -EIF3G 0.983422491559563 -MRPL4 1.13185886619774e-07 -PDE4A 0.976417636472092 -ICAM3 2.07707792396741e-22 -CDC37 0.96235789574322 -ZGLP1 0.437504524225803 -PPAN 1.16703694174413e-08 -DNMT1 0.999999999466791 -C19orf66 0.930534705136745 -P2RY11 9.07591188729782e-08 -TYK2 0.00431448241977221 -ANGPTL6 2.76981473339532e-08 -S1PR2 0.127343395339276 -FDX1L 0.00318935064209165 -PPAN-P2RY11 1.16703694174413e-08 -KEAP1 0.251629057539983 -RAVER1 0.982340267394972 -ICAM4 1.53444721877808e-05 -ICAM1 0.11779732116171 -DOCK6 2.83089712599404e-19 -TMED1 0.000162416907640562 -SPC24 0.00627554442927794 -ATG4D 0.000323903626106917 -CARM1 0.999357708272541 -SLC44A2 0.0414645881648824 -YIPF2 0.00109917458451604 -AP1M2 0.00134595247967371 -LDLR 2.59266073718312e-16 -KRI1 8.4034020734588e-09 -SMARCA4 0.999999997611829 -DNM2 0.999968599089655 -ILF3 0.999996830604967 -C19orf80 2.61107498638975e-06 -C19orf52 0.00198991933916563 -QTRT1 0.000223249642879381 -CDKN2D 0.147286959437682 -KANK2 0.981511998562845 -S1PR5 0.0574132950803294 -ACP5 0.123568347500175 -RAB3D 0.00142628412727186 -PRKCSH 0.140789247885124 -ZNF491 5.1306652954028e-07 -TMEM205 0.394574027164483 -ELOF1 0.403135808004397 -EPOR 0.058450671852552 -ELAVL3 0.822602583621291 -DKFZP761J1410 0.990015903872762 -ZNF441 0.0276670958531812 -ZNF627 0.00564414625423386 -CCDC159 9.21303782326294e-05 -ZNF823 2.08858743468726e-06 -CNN1 0.861520643189048 -RGL3 4.36378939273708e-21 -TSPAN16 0.000252237775125353 -CCDC151 8.76721164897311e-07 -ECSIT 0.0156465744672347 -SWSAP1 0.000134670403718243 -ZNF653 0.142112312658903 -ZNF625 0.000825561501317101 -ZNF844 1.00623256693283e-05 -ZNF700 4.39166088843519e-11 -ZNF799 6.79320285817144e-05 -ZNF490 0.0720463357958959 -ZNF439 3.21400432787086e-08 -ZNF443 1.8302370216888e-05 -ZNF442 1.47367601702494e-07 -ZNF878 1.48979796633174e-07 -ZNF440 5.58999225635548e-13 -ZNF20 0.0235723668010903 -ZNF788 0.0529943896875062 -ZNF563 8.58045673584715e-07 -ZNF433 1.9474436020732e-12 -ZNF763 0.000236872840014969 -ZNF709 5.65103851089128e-06 -ZNF136 1.49304930601206e-08 -ZNF44 8.93827649124464e-07 -ZNF69 7.35111939274279e-05 -ZNF564 8.59098537312022e-05 -FBXW9 1.9961927856908e-09 -C19orf43 0.310238874056668 -ZNF791 0.00827190470326655 -ASNA1 0.415776038206036 -DHPS 0.0034521520485461 -KLF1 0.000201077104049452 -JUNB 0.585014693290371 -HOOK2 6.32320511450437e-09 -BEST2 9.01637143288031e-11 -MAST1 0.999999024385856 -PRDX2 0.496065280846928 -WDR83 8.21261876456272e-07 -TNPO2 0.999885944036715 -GCDH 0.335283401044871 -RNASEH2A 0.0500791342521709 -MAN2B1 1.56344757218082e-12 -DNASE2 0.0537334042909933 -SYCE2 0.419255589823281 -WDR83OS 0.0017668610956485 -RTBDN 3.27850963623921e-07 -CALR 0.93872855492894 -CACNA1A 0.999999999776293 -IER2 0.681051567438311 -NANOS3 0.0079050763229906 -MRI1 0.000533201017712655 -FARSA 0.00405072098603709 -PODNL1 2.50976901279169e-14 -NFIX 0.989066455193014 -DAND5 1.6833196311109e-05 -LYL1 0.672721211231352 -TRMT1 8.74407139367611e-06 -CCDC130 0.0250490309774666 -ZSWIM4 0.165803304138144 -CC2D1A 2.25920260836964e-05 -C19orf53 0.236661551576513 -C19orf57 7.18269130933177e-05 -RAD23A 0.0392565362650634 -GADD45GIP1 0.000318097001528209 -NACC1 0.964946936209724 -STX10 3.56682385992079e-10 -RFX1 0.998752687183383 -CD97 0.457713952733134 -ASF1B 0.565696011085809 -CLEC17A 0.00261885555437633 -TECR 0.75750138958229 -PKN1 0.8546946397822 -DDX39A 0.843485807212333 -LPHN1 0.999999837146104 -SAMD1 0.204726948541933 -PRKACA 0.959056420321561 -GIPC1 0.020370586194085 -IL27RA 8.96991107032681e-07 -NDUFB7 0.0454659220811184 -DNAJB1 0.372156950000017 -RLN3 9.7759868484547e-05 -DCAF15 0.995060211995185 -PTGER1 0.255749329233531 -OR7C2 0.0424490324584504 -SLC1A6 0.92891102404997 -OR7A5 0.00139716936458155 -OR7C1 0.220027090245229 -SYDE1 0.946542806698739 -BRD4 0.999993446254695 -WIZ 0.998940437498306 -OR7A17 0.000117083033671137 -AKAP8L 0.542386261243836 -CASP14 0.00123388115759124 -OR7A10 0.00799298151690713 -ZNF333 3.59807075705962e-09 -EMR2 2.59136548105284e-13 -AKAP8 0.982554657107455 -EPHX3 5.04640148477413e-07 -CCDC105 2.33924477325218e-10 -NOTCH3 0.207712384985181 -EMR3 1.98539021355556e-18 -ILVBL 1.13705980806844e-05 -OR1I1 0.00172068988698609 -OR10H2 0.00763643549782811 -CYP4F2 3.52044589215636e-11 -PGLYRP2 1.33294125207149e-08 -CYP4F12 1.17932482773986e-09 -OR10H4 0.000560233320852483 -CALR3 8.79344302331144e-08 -CYP4F11 8.07506373684772e-15 -EPS15L1 0.970002535208416 -AP1M1 0.842349723177368 -RAB8A 0.962128955227462 -CYP4F22 0.000303611080808048 -KLF2 0.741705189487728 -OR10H5 0.0439530042449772 -RASAL3 8.34612284891441e-07 -CIB3 4.43323180861714e-07 -CYP4F3 6.83107684815361e-14 -TPM4 0.10940201669772 -OR10H1 0.637065115563279 -FAM32A 0.00905286803934175 -OR10H3 0.00545455982092705 -SMIM7 0.417815346539789 -NR2F6 0.152636356323805 -F2RL3 0.00302235446967585 -ANKLE1 8.12214719428193e-14 -BABAM1 0.729375765332217 -OCEL1 0.00014470501488926 -SIN3B 0.992239405222561 -C19orf44 4.21594047842148e-07 -CPAMD8 2.01801525841884e-14 -MRPL34 0.0401284434162437 -NWD1 1.37145309271971e-19 -SLC35E1 0.0968428302685581 -MYO9B 0.999998877096737 -USE1 0.0148417064935115 -TMEM38A 0.0307601657795331 -USHBP1 3.2784377499068e-13 -CHERP 0.999988395698518 -MED26 0.948549941884627 -ABHD8 0.642340812644093 -HAUS8 0.000726405158492587 -B3GNT3 0.200971950070002 -MAP1S 0.637852410524494 -SLC27A1 0.000340153810588742 -RPL18A 0.963491173324846 -PGLS 0.0420579993703126 -FCHO1 0.998992547558912 -JAK3 0.995863799803735 -FAM129C 1.3407670261693e-10 -UNC13A 0.999986711013614 -COLGALT1 0.00373035647810141 -SLC5A5 0.740011195140398 -PLVAP 0.000801226857051978 -MVB12A 0.000679169344270236 -NXNL1 0.0616906043285848 -DDA1 0.893417441694708 -GTPBP3 0.0447520916377848 -INSL3 0.0341265074058471 -ANO8 0.99293631682763 -BST2 0.000608698681329368 -PDE4C 4.88574724786651e-05 -JUND 0.560887373754993 -IFI30 2.60170027654508e-05 -ELL 0.940941238331597 -LSM4 0.667371394425323 -KIAA1683 8.28481624156168e-06 -ISYNA1 0.00263929952719535 -FKBP8 0.9787380986207 -GDF15 0.000282486503125805 -CCDC124 0.316957011367778 -PIK3R2 0.939626884464957 -MAST3 0.998925260617839 -MPV17L2 1.67296107198305e-07 -RAB3A 0.870967555184365 -ARRDC2 5.13482607596469e-05 -SSBP4 0.96165888216155 -KCNN1 0.931699633359926 -PGPEP1 0.000353365407990264 -LRRC25 0.943472206020923 -IL12RB1 1.17876777144483e-07 -HOMER3 0.222332288001803 -CRLF1 0.026855594173361 -COPE 0.6166479413462 -CERS1 0.0454570437212016 -UBA52 0.4468000697986 -ARMC6 7.24407726209859e-07 -GDF1 0.544923744446604 -CRTC1 0.980548236291021 -DDX49 3.23743409567641e-10 -UPF1 0.999926075341711 -KLHL26 6.67074241107322e-05 -TMEM161A 2.04658505555468e-06 -C19orf60 0.249879077699029 -KXD1 0.14091588201121 -MEF2BNB-MEF2B 0.247287511423171 -TMEM59L 0.0151007864967939 -SLC25A42 0.208308450498004 -SUGP2 0.999366871236062 -MEF2B 0.590447262915793 -SUGP1 0.9996355600486 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0.000233579258381277 -ZNF93 0.00169182185612759 -ZNF626 2.3449662444854e-07 -ZNF730 1.85625397322033e-10 -ZNF681 2.16277598625636e-08 -ZNF98 1.80227058167028e-06 -ZNF257 1.12139154354786e-09 -PLEKHF1 0.0990669966135396 -ZNF729 3.73171701464113e-10 -ZNF676 1.6869849435551e-06 -ZNF675 3.87871887390171e-06 -ZNF254 9.14795443372819e-27 -RPSAP58 0.581630356470054 -ZNF492 0.0174306218221897 -UQCRFS1 0.694438038047755 -ZNF99 3.03739918530551e-09 -C19orf12 0.667745724331567 -ZNF91 9.91964825661981e-05 -ZNF724P 0.00669603090666866 -POP4 0.14347717043933 -ZNF728 1.3589524035837e-07 -GPATCH1 3.44131002476153e-05 -LRP3 0.0392366539527002 -URI1 0.211667123362299 -PDCD5 0.00712094198898545 -C19orf40 2.661659462694e-05 -ZNF507 0.885285923722225 -NUDT19 1.09335740830484e-05 -CEP89 4.17121506628981e-20 -ANKRD27 7.78948328153526e-16 -SLC7A10 0.00157745429809636 -SLC7A9 0.246082407596558 -TSHZ3 0.425645582007279 -DPY19L3 0.0800404724813009 -WDR88 3.2982521257479e-08 -CCNE1 0.268926805475888 -ZNF536 0.965216841600083 -RHPN2 0.000336630552508902 -RGS9BP 0.0377028737179309 -ZNF181 3.18285421882246e-08 -ZNF792 3.90385673725562e-07 -UBA2 0.999673179363343 -LSM14A 0.383919740881151 -PEPD 0.014507135033171 -GRAMD1A 0.568380698661449 -KCTD15 0.130646194089883 -KIAA0355 0.877125217335467 -ZNF599 4.70007785154845e-07 -WTIP 0.00279904745490993 -SCGB2B2 0.000675653451540748 -HPN 0.997916181778818 -GPI 0.0015814519272106 -PDCD2L 4.99044178798444e-05 -ZNF30 8.05996775258386e-09 -CEBPG 0.0693755459843514 -ZNF302 0.00707195558979917 -SCN1B 0.205166938448244 -CHST8 0.00422201568083706 -FXYD3 0.00343233596536991 -FXYD1 0.233039911970241 -LGI4 0.0263199127837975 -DMKN 3.47258381606507e-09 -KRTDAP 0.0753309193944416 -SBSN 0.03514528123125 -LSR 5.33569632293939e-08 -USF2 0.992520444067371 -TMEM147 0.137954529384416 -FFAR2 0.000643946787473112 -GAPDHS 0.135772125697306 -HAMP 0.0425051340417533 -CD22 0.0308498751154716 -FXYD7 0.122293436649701 -MAG 0.540766816780039 -FAM187B 3.6655613907075e-06 -FFAR1 0.00137025456396348 -GPR42 0.659177796443367 -FXYD5 0.464175278334183 -PSENEN 0.535694860133088 -RBM42 0.759889530892988 -ZBTB32 0.0162101668651277 -LIN37 0.356935099324916 -UPK1A 3.36196571713144e-05 -KMT2B 0.999999997452585 -APLP1 0.525926955621001 -U2AF1L4 5.80258583719614e-07 -KIRREL2 8.95380796903671e-06 -COX6B1 0.0816220932965698 -ARHGAP33 0.212248410336133 -IGFLR1 0.00016488397901589 -PRODH2 7.20821354097691e-12 -NFKBID 0.795064373784277 -ATP4A 6.98616960990842e-08 -NPHS1 7.72410839762903e-11 -C19orf55 5.1009443214932e-06 -HAUS5 0.000826136639407559 -ETV2 0.0328967978548939 -HSPB6 0.391248531059943 -THAP8 0.00063975214571545 -ZFP14 0.000162247685567042 -POLR2I 0.0541602779086594 -ZFP82 0.0523308001818033 -HCST 0.0119335980806641 -CLIP3 0.99856772100268 -COX7A1 0.00356251777188197 -ZNF565 0.00176668862893038 -ZNF260 3.06605450053892e-06 -ZNF146 0.811745908933633 -SDHAF1 0.106593833761682 -SYNE4 5.95759018587848e-11 -ALKBH6 0.468934189734711 -WDR62 3.70153772737001e-13 -TYROBP 0.485203146508796 -LRFN3 0.860302995582065 -TBCB 0.405521802570773 -ZNF566 0.637363544825764 -CAPNS1 0.000124379798692998 -ZNF570 0.0012328637860006 -ZNF420 3.29013380261281e-08 -ZNF567 1.86506738570689e-06 -ZNF585B 0.00569166584170305 -HKR1 2.71836692118079e-10 -ZNF850 0.188901355257348 -ZNF790 3.27623626050772e-12 -ZNF382 0.853323188005293 -ZNF529 0.00106713686759093 -ZNF829 1.84766387824288e-08 -ZNF585A 0.711326551856647 -ZNF568 4.90822988396935e-09 -ZNF540 0.00697652985699623 -ZNF461 3.15672573724231e-06 -ZNF569 3.32583134908488e-05 -ZNF527 4.1248836635378e-05 -ZNF793 5.30990814631529e-06 -ZNF383 6.27662995876316e-08 -ZNF345 2.33150075364907e-11 -ZNF573 9.43002239919919e-09 -SIPA1L3 0.999676985877316 -SPRED3 0.422884638271983 -FAM98C 3.566522831586e-10 -ZNF607 8.48062246875504e-08 -PPP1R14A 0.287406516614265 -SPINT2 0.0296186146049727 -KCNK6 0.199609234281455 -ZNF571 2.82738476091202e-09 -DPF1 0.988986049504721 -ZFP30 9.06361318152477e-08 -C19orf33 0.269214271948265 -YIF1B 0.0375242137865894 -RYR1 1.60965844168568e-07 -CATSPERG 1.31477258507678e-11 -PSMD8 0.176154540930518 -ZNF781 7.22160643082208e-06 -GGN 0.134074173944406 -RASGRP4 0.0501177515861943 -CAPN12 7.47956767719308e-20 -RINL 0.0301105358577335 -PAPL 5.71443054609324e-06 -NCCRP1 0.000145564407364416 -EIF3K 0.00233163486953566 -PAK4 0.701123853426304 -SARS2 5.30599942085599e-05 -NFKBIB 0.249570217341025 -ECH1 0.00416642683428467 -MRPS12 0.0104262673685507 -CTC-360G5.1 0.384220416304139 -LGALS7B 0.478395552225766 -LGALS7 0.43376704344564 -HNRNPL 0.945068590001273 -FBXO27 2.08184662248635e-10 -LGALS4 6.568948476447e-06 -SIRT2 1.0819075859999e-05 -ACTN4 0.999989804555774 -MAP4K1 0.991409179038241 -FBXO17 1.22848221120316e-07 -TIMM50 0.442656936727353 -DLL3 1.65028093606891e-05 -ZFP36 0.64593418279633 -SELV 0.000392719436698933 -LGALS13 6.77894375320678e-05 -SYCN 0.0057265264493716 -LGALS16 4.37119316925913e-05 -IFNL1 2.82388297192014e-05 -EID2 0.750053234702107 -LRFN1 0.830755525384285 -GMFG 1.91273633031565e-05 -PLEKHG2 3.5925547959503e-08 -PAF1 0.845472629917094 -IFNL2 1.95487204221475e-05 -SAMD4B 0.998551353474612 -IFNL3 1.15936762956742e-05 -MED29 0.00101225805500751 -RPS16 0.28185910292269 -SUPT5H 0.999999734600741 -EID2B 0.126192494543355 -ZNF780A 1.73286195326953e-06 -SERTAD3 0.0653917301176075 -DYRK1B 0.915927122253969 -PLD3 0.015972164288732 -ZNF546 2.54471129517444e-10 -AKT2 0.997816206855922 -CNTD2 0.114056188535974 -ZNF780B 3.89667579331898e-13 -C19orf47 0.802242558770503 -LGALS14 0.0100122793683261 -PSMC4 0.605976545511019 -CLC 3.41778388787621e-05 -PRX 3.70050570170033e-11 -HIPK4 0.00392487635427892 -TTC9B 0.0271797942742283 -FBL 0.984496356217353 -MAP3K10 0.792721034473586 -SERTAD1 0.0421844903041302 -SHKBP1 0.000346950937358068 -HNRNPUL1 0.99984751233348 -AXL 0.76630115087899 -NUMBL 0.751917062061139 -CYP2B6 2.29255534734584e-05 -EGLN2 0.286988738826209 -SNRPA 0.0602794492639456 -CYP2A13 0.00143445702978295 -CYP2F1 2.75609758938668e-05 -LTBP4 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2.0744645910844e-09 -ZNF222 9.20501288480146e-11 -CADM4 0.979491544538579 -ZNF428 0.720275479182866 -PLAUR 0.3065849263056 -ZNF223 5.14224553323192e-09 -ZNF226 5.26919185197287e-15 -LYPD5 9.4450522196327e-05 -ZNF225 3.36669333303033e-08 -ZNF283 4.46246793803596e-08 -KCNN4 8.36465970463448e-06 -ZNF221 2.58051484113414e-09 -IRGC 0.0437355066124445 -ZNF234 1.07736675935267e-13 -ZNF180 7.35726181171227e-06 -CBLC 0.000182989540193376 -CEACAM16 0.0295802581415047 -PVR 5.51101308161619e-07 -APOC2 0.0227961322934307 -ZNF229 6.30663414582273e-09 -ZNF112 0.154211257518811 -ZNF235 1.85820362433789e-10 -ZNF285 0.00240305532090865 -APOE 0.0345335830833016 -BCL3 0.86217268510329 -CEACAM19 5.7765093789489e-07 -APOC4 0.000150692347626422 -ZNF233 3.27015906549736e-17 -ZNF227 1.69159989152872e-05 -BCAM 0.0368511835228543 -TOMM40 0.963682323765023 -PVRL2 0.531937435077773 -APOC1 0.0507382728810443 -ZNF296 0.97328866403764 -RELB 0.973562746007932 -CD3EAP 5.68877488151799e-05 -EXOC3L2 0.925564031557031 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0.580172431977243 -PGLYRP1 0.167200721076412 -AC011484.1 0.00296221553037229 -NANOS2 0.575905924394273 -PRKD2 0.9996964074254 -GNG8 0.147000773638907 -IGFL4 0.00312950335672231 -IGFL2 0.000244160956618864 -HIF3A 0.218113050468269 -PNMAL1 0.0444369604042834 -IGFL3 0.00109378557531111 -PPP5D1 0.0393450229909042 -TMEM160 0.654855932901688 -NPAS1 0.916472527076156 -CCDC9 1.56831799563654e-06 -SAE1 0.988952422396941 -BBC3 0.0712435383459735 -ZC3H4 0.999999772424525 -SLC1A5 0.0518112085245823 -ARHGAP35 0.999989834870149 -STRN4 0.999575131657329 -KPTN 0.000791094717132057 -FKRP 0.000382800164368902 -C5AR1 0.000416365501777882 -DHX34 2.87824570211658e-08 -NAPA 0.974655184511478 -C5AR2 0.0231409770825171 -AP2S1 0.919495985397116 -MEIS3 0.000113442628590687 -GLTSCR2 0.253946323601522 -TPRX1 0.000613267786761704 -CCDC114 0.00270689727205249 -LIG1 0.0177050971960458 -CARD8 0.0162893753878883 -EHD2 0.531641412437229 -ZNF114 1.07440174482829e-06 -CRX 0.623714816368051 -SULT2A1 1.38583676529622e-07 -TPRX2P 0.0116462336341647 -GLTSCR1 0.997123313976457 -PLA2G4C 4.41932214366148e-08 -SYNGR4 0.00121574866110408 -TMEM143 3.71457884922687e-08 -SEPW1 0.000743620933357238 -ELSPBP1 0.000181420081969443 -EMP3 0.000573648342962621 -CABP5 0.00422080325588394 -GRIN2D 0.998648757458714 -RASIP1 0.975494281851725 -CYTH2 0.863501033367183 -KCNJ14 8.51179265459349e-05 -KDELR1 0.895487511877841 -CA11 0.976097038480165 -GRWD1 0.337778593629583 -RPL18 0.554781180671353 -IZUMO1 0.00241626337305742 -NTN5 3.27017246498834e-06 -SULT2B1 0.827919001656143 -SPACA4 0.577152663282386 -FAM83E 6.61984443140011e-06 -SPHK2 8.66423863572204e-06 -DBP 0.820194274770572 -MAMSTR 0.00123325809401916 -FGF21 0.213002020207769 -FUT1 0.000508774873537715 -FUT2 5.46581459214613e-12 -PPP1R15A 3.34188774969249e-09 -HSD17B14 0.00137252498082087 -GYS1 0.00832267410134216 -FTL 0.000458652707063046 -NUCB1 4.16610548641566e-05 -PLEKHA4 4.7425343910477e-09 -CGB1 0.267464648266522 -TULP2 1.82654937164633e-07 -BCAT2 1.71339042998067e-11 -DHDH 3.48849486684174e-06 -CGB 0.574072270101342 -BAX 0.167938540925625 -NTF4 0.107582900179627 -CGB2 0.0694219778865575 -CGB8 0.0917779548101803 -CGB7 0.0131018383509561 -RUVBL2 0.999110080217839 -KCNA7 0.00825022329951349 -LHB 0.065600109491978 -CD37 0.00640181376663543 -TEAD2 0.00204731673714379 -RPL13A 0.633828368843267 -SNRNP70 0.993095085568321 -PPFIA3 0.99999959495107 -FLT3LG 0.950828697992112 -SLC17A7 0.995932824968909 -LIN7B 0.838837249627908 -DKKL1 0.000105207763605655 -RPS11 0.913344861476602 -PTH2 0.522952191907171 -HRC 3.13676309509999e-05 -SLC6A16 4.47639511693954e-11 -ALDH16A1 1.35194745543971e-07 -CCDC155 7.22301101921984e-07 -C19orf73 0.48401312075747 -TRPM4 6.36301802229804e-19 -PIH1D1 0.087951252701366 -PRR12 0.999969576883676 -CPT1C 0.0002846277169503 -MED25 0.00112987749552536 -NOSIP 0.00230156568092138 -AP2A1 0.9998472799622 -RCN3 1.77726445447237e-09 -BCL2L12 1.55699450949424e-05 -IRF3 0.00321741798317075 -PRMT1 0.993587786937211 -TSKS 0.980813772290248 -RRAS 0.287257428796457 -ADM5 0.0362143986281022 -SCAF1 0.998787538768532 -PNKP 2.8844490761323e-07 -PTOV1 0.358456527279287 -TBC1D17 1.1203244858319e-12 -PRRG2 5.96505604158473e-05 -FUZ 0.00208816398655203 -AKT1S1 0.476648977204292 -FCGRT 0.825587179671645 -SPIB 0.899853669858548 -IZUMO2 1.06861878364753e-05 -POLD1 0.00180701093302935 -LRRC4B 0.297156810786189 -SIGLEC11 2.64293930264503e-08 -EMC10 1.56498022796748e-07 -FAM71E1 0.00613239345260664 -KCNC3 0.850943334894472 -JOSD2 0.428022033640029 -IL4I1 0.262058044797637 -ASPDH 0.00111133387539319 -NUP62 0.804394184233739 -MYBPC2 4.01401681109932e-17 -ZNF473 0.774568360403142 -ATF5 0.0226677802943902 -NR1H2 0.821872624160323 -NAPSA 7.95882589543694e-07 -VRK3 1.57414497489905e-06 -MYH14 0.999847921380196 -SYT3 0.225605579212027 -GPR32 7.90945665733303e-05 -KLK9 0.00393894270251681 -KLK4 0.020194728883179 -KLK11 0.0574751215215554 -KLK6 0.497244483744415 -KLK1 0.000319896608295988 -KLK13 0.755462837830593 -C19orf48 0.551060129678645 -KLK8 0.00338366631961467 -KLK12 0.00182411651683503 -SHANK1 0.999999760947139 -KLK7 0.00688296460219149 -KLK10 4.40787331105343e-05 -KLK2 0.00029249151077166 -ACPT 1.219018604775e-13 -KLK3 0.00347267051874821 -KLK15 0.0465802581941977 -KLK5 0.0727607206770689 -CLEC11A 0.00226672639831053 -LIM2 0.000989156576930138 -SIGLEC12 1.54311758491148e-10 -SIGLEC8 0.000488762401895089 -KLK14 1.09820370579845e-09 -SIGLEC10 4.05540868320963e-06 -CEACAM18 4.11404429372682e-10 -ETFB 0.00371616291629958 -SIGLECL1 0.00033234714417744 -CTU1 0.134628145231563 -SIGLEC9 0.0003283348922794 -NKG7 0.00400666235764945 -IGLON5 0.822062298227498 -SIGLEC6 0.024724478649233 -CD33 2.30635094021775e-05 -CLDND2 3.86931508471866e-05 -SIGLEC7 8.9311366832357e-06 -ZNF175 0.000451569387912362 -FPR1 0.0638058133694423 -SIGLEC14 0.0356627411821091 -ZNF614 0.00212062774091326 -ZNF610 1.22048067047747e-10 -ZNF836 3.01932501527445e-09 -ZNF841 4.04876108417812e-08 -ZNF766 7.45003861398477e-08 -FPR2 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-ZNF547 2.11764938034053e-11 -AC004076.9 0.00560569469571997 -ZNF264 7.10064544025699e-06 -ZNF749 1.62775731696662e-06 -ZNF773 5.50268566614554e-09 -ZNF17 0.000331513211563741 -ZNF805 0.79436861206606 -AURKC 0.151759586463599 -ZIM3 4.31741951284123e-11 -ZNF772 0.00795615487412956 -USP29 9.28685713630925e-15 -ZNF304 0.852650320351142 -PEG3 0.00190815720491937 -VN1R1 0.310171245019823 -ZNF460 0.647011501763315 -TRAPPC2P1 0.163282001723772 -DUXA 3.05558525416354e-05 -ZNF154 5.18955297882032e-05 -ZNF211 3.03205891351883e-08 -ZNF550 1.52466918014378e-10 -ZNF671 4.2192652974031e-13 -ZNF134 0.00114550101606897 -ZNF417 1.12805634572858e-06 -ZNF416 0.000574203935929878 -ZNF587B 0.00809264304487427 -ZSCAN4 0.0045989531196528 -ZNF587 0.000253450002154461 -ZNF530 1.74303796061719e-10 -ZNF814 6.74808519166839e-10 -ZNF551 6.09496732792038e-07 -ZIK1 4.78889151995357e-08 -ZNF418 4.09196213504996e-21 -ZNF552 0.0119441082095416 -ZNF549 5.83117375145472e-05 -ZNF776 7.87023474197769e-06 -ZNF586 0.00501217619840313 -ZNF446 3.39122166459363e-06 -ZNF497 5.39461755578373e-08 -ZNF135 3.86627866810006e-09 -ZSCAN1 6.40276120105453e-07 -ZNF837 0.25844063599264 -ZNF584 1.31169156351203e-05 -ZNF132 8.15053229528725e-13 -ZNF606 0.320389649972156 -ZNF324 0.473925409395351 -ZSCAN22 1.28988100682587e-05 -ZNF256 1.77459004146427e-05 -ZNF274 0.00724982193908302 -ZNF329 2.30642332748683e-05 -RPS5 0.903178121006896 -ZSCAN18 0.748253934473653 -ZNF324B 0.00574789788111746 -ZNF544 3.81192076143802e-13 -A1BG 9.0649236354772e-05 -C19orf18 6.22105573112122e-05 -TRIM28 0.999902029147243 -UBE2M 0.619518063416814 -MZF1 1.81494742445282e-06 -ZBTB45 0.0266369804255781 -CHMP2A 0.906239123113201 -SLC27A5 7.7072921738533e-08 -SCRT2 0.364922305004282 -DEFB128 0.560121291818518 -DEFB132 0.00647477436924981 -RBCK1 0.212094447600287 -DEFB125 0.000941817347898508 -TRIB3 2.11620965891956e-10 -DEFB126 0.000723030120606571 -DEFB129 0.0087103445415641 -SRXN1 0.00865787938463754 -TCF15 0.551527504830997 -FAM110A 0.74779060333009 -SLC52A3 0.00162509373291456 -CSNK2A1 0.999646697845993 -TBC1D20 0.912642498359472 -C20orf96 7.45279920330834e-13 -NRSN2 0.00197331172132976 -DEFB127 7.41963201429962e-06 -RP5-850E9.3 0.0319577463572883 -FKBP1A 0.678638213250307 -RSPO4 0.000413043495572724 -SIRPG 5.20922689402416e-08 -STK35 0.918199525844565 -SIRPA 0.137720810094911 -SIRPD 7.78200741287581e-05 -TGM3 9.8674987422054e-06 -SNPH 0.796091125666896 -PDYN 0.000256778020981015 -SIRPB2 0.0145880945141627 -NSFL1C 0.159362129254894 -TGM6 2.75865000258514e-18 -TMEM74B 0.00147382150329057 -PSMF1 0.000147581676028268 -SDCBP2 0.410340821760316 -SIRPB1 2.22163067811888e-09 -ANGPT4 2.06397344414755e-09 -MRPS26 0.187857587540762 -SNRPB 0.691451244777475 -IDH3B 3.06237188855065e-05 -VPS16 2.29458119355575e-05 -LZTS3 0.875742310525438 -FASTKD5 3.4250816581256e-06 -C20orf141 0.000122910761361037 -CPXM1 2.33840235512205e-11 -DDRGK1 0.000149759368683589 -ZNF343 1.21297037084745e-14 -AVP 0.183145102453943 -TMC2 7.88651863410026e-16 -PCED1A 0.0160267066093378 -GNRH2 0.000228749333342023 -UBOX5 0.00178682505370842 -PTPRA 0.999976743548953 -NOP56 0.973256819691124 -EBF4 0.0780569989244377 -OXT 0.62795746033166 -C20orf27 0.0270989162488399 -SPEF1 0.000189254509549096 -ADAM33 1.31263464951389e-11 -SMOX 0.837563765963898 -MAVS 1.76704995629944e-07 -PANK2 0.0107918334564396 -RNF24 0.898356865489774 -SIGLEC1 1.62408118412598e-28 -GFRA4 0.00834571960566959 -CDC25B 0.590733232372986 -SLC4A11 1.36725840636298e-08 -ITPA 8.97319725886936e-05 -PRNP 0.0291390272600768 -ATRN 0.999999975840269 -AP5S1 0.000277046194039352 -C20orf194 0.00600469217397855 -HSPA12B 0.0105082037359554 -CENPB 0.973451328276556 -LRRN4 1.45171418519099e-08 -HAO1 0.000672388585939552 -TMEM230 0.0138196085002164 -MCM8 1.92893351081766e-10 -PLCB1 0.979044816094075 -FERMT1 7.56849863577804e-07 -TMX4 0.0106621809140241 -C20orf196 0.333004444219793 -PRND 0.0677966552935181 -CRLS1 0.0335080599829462 -BMP2 0.938086415869115 -SLC23A2 0.511221636863337 -PROKR2 0.000669053120174497 -RASSF2 0.000156231740850229 -PCNA 0.937503505123045 -TRMT6 0.000492531588783058 -GPCPD1 0.125571598748616 -CDS2 6.78080961217838e-05 -CHGB 3.81635895457789e-07 -PRNT 0.105498859424942 -MKKS 4.23711359687125e-09 -BTBD3 0.0614215773226243 -SEL1L2 2.6912869713909e-11 -KIF16B 4.35337119724975e-13 -ESF1 0.0844452787570408 -SNAP25 0.959806530251926 -FLRT3 0.988394618338844 -NDUFAF5 1.00133797830871e-05 -LAMP5 3.83650327709959e-08 -ANKEF1 2.75187176643953e-09 -MACROD2 0.0113567470210345 -SLX4IP 2.33883944799938e-05 -SPTLC3 0.00275524015888074 -TASP1 0.956178727459365 -PAK7 0.998363566588201 -PLCB4 0.272263498048569 -JAG1 0.999999615868819 -ISM1 0.0542221895137127 -SNRPB2 0.320265019109405 -RRBP1 0.000136331977393793 -SNX5 0.449845570451869 -OVOL2 0.436097284181233 -POLR3F 0.00386617468438894 -BANF2 0.0481236094609711 -RBBP9 0.10391013399072 -SCP2D1 0.0315534483185386 -ZNF133 0.949610073341142 -OTOR 0.0148213358106119 -SEC23B 6.85928695809641e-14 -BFSP1 0.000105944351029142 -CSRP2BP 1.34916992593767e-08 -DTD1 0.290212859228027 -MGME1 0.0036143276897704 -PCSK2 0.994186021657942 -DZANK1 4.59513480508911e-15 -SLC24A3 0.959518180659547 -DSTN 0.759201434624303 -C20orf26 6.86648939566699e-10 -RIN2 0.0082955850905875 -CST11 0.00483331194609008 -CD93 7.81902169131146e-10 -PAX1 0.616084025991163 -NAA20 0.0136063641752257 -CST8 0.0856291456541582 -NXT1 0.574740218091013 -CSTL1 0.000159597987763541 -SSTR4 8.69093826267664e-05 -NKX2-2 0.337334271714038 -NKX2-4 0.278447692496314 -RALGAPA2 8.48775696516084e-06 -GZF1 0.00788572311664667 -XRN2 0.813170185835591 -CRNKL1 0.881981246509602 -NAPB 0.989108778039473 -SYNDIG1 0.433641202646478 -GGTLC1 0.000145547384937393 -NANP 0.0265416473766969 -VSX1 0.00659973339577821 -CST9L 2.08251924122082e-10 -CST5 0.0216483919651051 -PYGB 4.76485243414978e-07 -ZNF337 2.29239140713378e-09 -CST1 2.8669819797472e-08 -CST2 2.1850092249434e-06 -CST9 0.0951092949311725 -GINS1 0.0500369772330311 -ENTPD6 4.98993289171908e-05 -APMAP 2.35566376172495e-07 -CST7 9.91887068524384e-07 -ABHD12 1.98295570505197e-06 -CST3 0.0690352137873098 -NINL 3.96830789193205e-33 -ACSS1 0.00139669613638913 -CST4 7.30046884128097e-06 -TTLL9 4.48655268982384e-10 -DUSP15 0.000219668008201055 -ID1 0.00765557463426437 -PDRG1 0.00108693899519325 -DEFB119 0.0586265124896855 -DEFB118 0.0891188757776611 -DEFB123 0.00636985353515393 -HM13 0.882288325132847 -DEFB121 0.0315382968992368 -TPX2 0.992124193249196 -DEFB116 0.00162884060058742 -REM1 1.6783884226419e-05 -COX4I2 0.00147571485756203 -DEFB124 0.18733564893744 -MYLK2 0.220320911579183 -FRG1B 0.000302147160400711 -FOXS1 0.0996331503834563 -DEFB115 0.0337152856700566 -BCL2L1 0.823684827507086 -C20orf112 0.973021413632523 -TM9SF4 0.999970772411386 -PLAGL2 0.86979563793487 -MAPRE1 0.968087388852693 -ASXL1 1.37370457058834e-18 -XKR7 0.923951242528615 -BPIFB6 1.20126828012269e-11 -KIF3B 0.299149040547773 -SUN5 6.52856833944276e-11 -BPIFB3 1.27011210022581e-05 -COMMD7 6.04653686013292e-06 -BPIFB2 7.68879584989142e-08 -BPIFB4 3.46594612665667e-17 -POFUT1 0.987586067238811 -BPIFA2 0.00266486348314627 -CCM2L 0.00053799849805507 -DNMT3B 0.999774600266445 -BPIFA3 0.000409260412041777 -E2F1 0.95553054498313 -ZNF341 0.124189156815528 -BPIFB1 5.76895247746317e-07 -ASIP 0.0696266962093715 -NECAB3 0.797631144685702 -BPIFA1 3.60154382988658e-05 -EIF2S2 0.863603165264989 -CBFA2T2 0.999355101452129 -MAP1LC3A 0.739731534985187 -CHMP4B 0.881585919417872 -C20orf144 0.00309357257059548 -SNTA1 0.428235398198808 -ITCH 0.999990177147491 -AHCY 0.94406980715951 -CDK5RAP1 1.07824217963136e-14 -DYNLRB1 0.842802760335196 -PXMP4 0.604956427154611 -PIGU 0.813069113456619 -RALY 0.554573839722822 -ACTL10 0.0010526008602134 -GDF5 0.923194898928876 -PROCR 0.0101308888898987 -FAM83C 3.49242479222024e-05 -GSS 0.0225186832470012 -TP53INP2 0.341454389532318 -ERGIC3 0.0038590767192969 -ACSS2 8.97239307211796e-11 -TRPC4AP 0.999538656142253 -EDEM2 0.000137533138342907 -MYH7B 1.33080887914663e-23 -GGT7 0.998200259468736 -NCOA6 0.990815417122809 -GDF5OS 0.0423623916485043 -CEP250 8.25125524749097e-17 -CPNE1 3.87095095726686e-07 -SPAG4 0.110567923366472 -MMP24 0.0287623289506785 -EIF6 0.781942924365479 -UQCC1 0.00485442531990324 -NFS1 0.832120909457389 -ROMO1 0.726806954057013 -DLGAP4 0.991952626284089 -TGIF2-C20orf24 0.932314274654765 -DSN1 1.72357694081058e-06 -SAMHD1 1.50497735378024e-05 -SOGA1 0.997564311741111 -TGIF2 0.307264900831979 -C20orf24 0.856745481043852 -RBM12 0.474673920574839 -SLA2 0.384130951390547 -CNBD2 2.29296795546672e-07 -AAR2 0.000262136180238876 -EPB41L1 0.645386132721516 -SCAND1 0.158311342081053 -RBM39 0.9999969154952 -TLDC2 0.113178686310675 -MYL9 0.0660421350679322 -NDRG3 0.919621043818656 -PHF20 0.975739227580779 -RPN2 0.0316773430272863 -RPRD1B 0.595211393438137 -RBL1 1.76076225583568e-05 -PPP1R16B 0.998536940448375 -RALGAPB 0.999999955632558 -LBP 5.69197086647934e-14 -TGM2 4.86367266752489e-14 -BLCAP 0.468529446393196 -TTI1 0.000238871043749718 -GHRH 0.455312663756291 -MANBAL 0.169240549562547 -BPI 8.85642713755215e-09 -SRC 0.988983228456412 -KIAA1755 2.32481835791205e-15 -ACTR5 1.00014232070039e-12 -NNAT 0.112567959949874 -VSTM2L 0.362003649087479 -CTNNBL1 0.28580047936403 -TOX2 0.674075157439045 -SGK2 2.93457296557479e-07 -L3MBTL1 2.0785493269036e-07 -LPIN3 4.43532236084843e-11 -GTSF1L 0.0573625002264625 -PTPRT 0.999998893194682 -MYBL2 0.992108233056559 -GDAP1L1 0.353968502367603 -CHD6 0.99999999999754 -EMILIN3 0.00139809720973059 -DHX35 9.69273790916275e-11 -JPH2 0.0145044420330593 -FAM83D 2.57679581643321e-05 -OSER1 0.00872888785285661 -TOP1 0.999999399962319 -IFT52 0.00016303013234085 -ZHX3 0.354421202947907 -PLCG1 0.76335235197211 -SRSF6 0.992976413171211 -SEMG1 1.9424739088767e-14 -PKIG 0.564580331450696 -YWHAB 0.938360894039554 -PABPC1L 0.993349750139363 -ADA 2.83298527981767e-09 -WISP2 0.0016907930598105 -PI3 0.00564031437143875 -FITM2 0.000110416566392742 -SERINC3 0.590252231777824 -WFDC5 5.6017444083725e-05 -KCNS1 0.362998541245244 -RIMS4 0.952765434512064 -R3HDML 0.00299617468807422 -TOMM34 0.721089132713427 -STK4 0.118311921511212 -KCNK15 0.106847941612793 -TTPAL 0.640756733161688 -WFDC12 0.0568531699708981 -HNF4A 0.919225678145736 -SDC4 0.0118034906332036 -EPPIN 0.000111214074168112 -MATN4 9.70350471147918e-05 -SYS1 0.474140969012541 -DBNDD2 0.0506088642378966 -WFDC10B 0.0148433867661418 -TP53TG5 3.30244359376843e-06 -SEMG2 6.77030449388864e-15 -PIGT 4.65840286191537e-12 -WFDC11 0.00335013836988599 -WFDC6 0.054913983307631 -RBPJL 1.89367601104857e-11 -WFDC8 4.97250859518292e-06 -WFDC9 0.0108113463900981 -WFDC10A 0.27466328624647 -SLPI 0.00034794041537936 -WFDC2 0.634143544716743 -EPPIN-WFDC6 0.000111214074168112 -NCOA5 0.996800143883867 -ZSWIM1 8.44135177374488e-05 -SLC12A5 0.999987272496915 -PCIF1 0.999961615698865 -DNTTIP1 0.431436687799906 -ACOT8 3.56850509972552e-05 -ZSWIM3 0.00141328779660025 -WFDC13 0.252946356503913 -WFDC3 0.019237531618368 -SNX21 0.0208140161677358 -ZNF335 0.00650300156857181 -NEURL2 0.00262021372533022 -MMP9 2.78769685742866e-08 -SPATA25 0.000413851176082059 -CTSA 4.23467972299143e-05 -SPINT4 0.0933895217408077 -CD40 0.658237503542853 -TNNC2 0.547150267315584 -PLTP 0.000142042024392603 -UBE2C 0.218752616276181 -SLC2A10 0.00820173708336499 -ZNFX1 0.999981099240724 -ELMO2 0.000350882321256971 -EYA2 0.335504422060954 -DDX27 0.250170092340815 -TP53RK 0.349270745629922 -CSE1L 0.999981566389526 -ZNF334 4.08828905187586e-08 -KCNB1 0.982587869780031 -ZMYND8 0.999997106368404 -AL031666.2 0.159467559569008 -STAU1 0.996415824871937 -ARFGEF2 0.999999938266667 -SLC13A3 0.0532868032183935 -SLC35C2 0.0471490104786645 -NCOA3 0.999916717705241 -SULF2 0.878046240550913 -PREX1 0.999999621898147 -PARD6B 0.807577374871722 -MOCS3 1.13606849844989e-05 -B4GALT5 0.991657870655178 -RNF114 0.0170045996254868 -TMEM189-UBE2V1 0.00518500567573873 -PTGIS 2.42325399858621e-05 -UBE2V1 0.0019545255342164 -CEBPB 0.184473672069434 -ATP9A 0.999980637361735 -ADNP 0.9989040999292 -DPM1 0.536747471706315 -BCAS4 0.0466393235045461 -SLC9A8 2.81662458191787e-05 -FAM65C 1.45014435980138e-12 -KCNG1 0.274579646128645 -TMEM189 0.00518500567573873 -PTPN1 0.69764496881077 -NFATC2 0.99925103106598 -SNAI1 0.367002590610049 -SPATA2 0.848756563292112 -AURKA 0.435603931095833 -CASS4 0.296175209094422 -FAM210B 0.0723304939713369 -SALL4 0.999442034343346 -ZNF217 0.995447743940774 -DOK5 0.0439811915489279 -CYP24A1 3.24300393313511e-10 -PFDN4 0.100179293326146 -TFAP2C 0.939950974403548 -RTFDC1 0.00393227636872296 -FAM209B 0.0297206395001582 -CSTF1 0.937895869936688 -CBLN4 0.348291542584304 -FAM209A 0.0316770454966637 -ZFP64 0.00518985254415644 -TSHZ2 0.406843773399705 -MC3R 0.0013603798509996 -BCAS1 0.0136569957373472 -VAPB 0.739723829926661 -C20orf85 1.38449977889469e-05 -BMP7 0.98128676800379 -NELFCD 0.205977810131081 -ZBP1 1.29679362994319e-10 -RAB22A 0.685129847877273 -NPEPL1 1.80492173035865e-07 -CTCFL 0.78303184194046 -SPO11 0.000356300036119442 -GNAS 0.9995400816303 -PMEPA1 0.416594874357437 -RBM38 0.859282996288302 -PCK1 3.93284883371259e-08 -STX16 0.235503144787157 -RAE1 0.991169300003019 -CTSZ 1.31534221236972e-09 -APCDD1L 0.0175592164085508 -TAF4 0.999487085673133 -TUBB1 7.16532359955701e-06 -HRH3 0.366881477706972 -CDH26 5.55635014833331e-23 -FAM217B 0.0010813237416719 -SYCP2 0.999993566714356 -ATP5E 0.0060568330836871 -MTG2 0.000608857161369286 -EDN3 0.0723949084714923 -SS18L1 0.812233116235997 -SLMO2 0.24136867864781 -OSBPL2 0.50491184114321 -ZNF831 7.64881641877554e-09 -CDH4 0.966988413982154 -PSMA7 0.965751461122936 -PPP1R3D 0.0677652743829041 -PHACTR3 0.971713289002321 -C20orf197 0.0552321459200376 -LSM14B 0.967227480386856 -COL9A3 3.24916588705806e-05 -SLCO4A1 5.34100932440508e-07 -TCFL5 0.95806915495759 -GATA5 0.250742908677773 -C20orf166 0.00010961460910826 -BIRC7 0.00380290601773512 -MRGBP 0.905748427840226 -LAMA5 0.943037981027839 -GID8 0.961707185864695 -SLC17A9 5.26686938450496e-08 -YTHDF1 0.983709938969743 -CABLES2 0.000167846578276169 -NTSR1 9.72930758301054e-08 -BHLHE23 0.0601229173842303 -RBBP8NL 0.00748846457322915 -DIDO1 0.99999076875449 -ADRM1 0.981917517015876 -RPS21 0.46553481920164 -OGFR 0.0134181696647606 -STMN3 0.489817097149277 -LIME1 0.00033293549013144 -CHRNA4 0.0208678880743461 -KCNQ2 0.99935609863785 -SRMS 5.12640322619190e-12 -HELZ2 1.25628851402837e-09 -PPDPF 0.000225837231011149 -ZBTB46 0.814437307571674 -EEF1A2 0.96413145424868 -COL20A1 1.26872087443005e-24 -RTEL1 0.777758475451746 -C20orf195 0.000298557497544344 -GMEB2 0.990659130636514 -ARFGAP1 0.0166821066209427 -SLC2A4RG 0.00794438690680656 -NKAIN4 0.0237171845496393 -ARFRP1 0.135717560060112 -TNFRSF6B 4.83457783145428e-05 -ZGPAT 2.80185523268214e-05 -PTK6 1.17663250084696e-07 -ABHD16B 0.0330929687901713 -TCEA2 0.00781797115613869 -RGS19 0.879309173292519 -SAMD10 0.00605113928963302 -TPD52L2 0.595604698374735 -OPRL1 0.602075924384072 -DNAJC5 0.858492458762531 -MYT1 0.999871801547028 -C20orf201 0.0451217995183806 -ZNF512B 0.999557046056348 -UCKL1 1.42564770235951e-08 -NPBWR2 0.0022243335643839 -PRPF6 0.280831794647215 -PCMTD2 0.0123297627205191 -POTED 0.736659832423479 -CHODL 0.00128507754633277 -LIPI 8.82542393516549e-09 -TPTE 5.11403738742454e-31 -CXADR 0.342891274842555 -NRIP1 0.991172158226933 -RBM11 2.91015515635607e-05 -C21orf91 0.00484582012569912 -JAM2 0.148660697111206 -HSPA13 0.00188636989282119 -TMPRSS15 1.28977099814963e-18 -USP25 0.990130458125693 -SAMSN1 0.0756023579713905 -MRPL39 0.000718691512555642 -BTG3 0.696545555394833 -ATP5J 0.100188831785232 -NCAM2 0.922157338297282 -CLDN17 0.000147441730490406 -KRTAP26-1 0.0010066331061178 -CLDN8 0.0576343766009805 -ADAMTS1 0.594872990656586 -GRIK1-AS2 0.395414271289592 -RWDD2B 0.000174917032865459 -N6AMT1 0.00987178467583436 -LTN1 0.832714009845553 -BACH1 0.01418640000584 -GRIK1 3.20558900258698e-05 -KRTAP27-1 1.08863813473516e-05 -CCT8 0.982792760113934 -KRTAP24-1 9.16556642967582e-06 -MAP3K7CL 0.0022653891673035 -GABPA 0.973789161166602 -USP16 0.00586486313268796 -CYYR1 0.0344265894425975 -ADAMTS5 0.118850233550657 -APP 0.331710617165879 -KRTAP13-1 0.00711270612697186 -KRTAP13-3 0.000682837175576854 -KRTAP20-1 0.0232742114105319 -KRTAP19-4 0.0238880027709709 -KRTAP13-4 0.0077412086854088 -KRTAP6-3 0.532856911991667 -KRTAP19-5 0.00518271337885184 -KRTAP6-1 0.000321176229646924 -KRTAP19-1 0.0410480789430577 -KRTAP19-3 0.00440584340588175 -KRTAP19-7 0.14123495896819 -KRTAP15-1 0.00443716984404986 -KRTAP19-6 0.0203608220277465 -KRTAP13-2 0.000843088326991207 -KRTAP6-2 0.165055211325206 -KRTAP19-2 0.126076454825682 -KRTAP22-1 0.124017870650419 -KRTAP23-1 0.454990924430803 -SYNJ1 0.2142951462835 -TIAM1 0.999932006469338 -EVA1C 0.325814898143043 -MIS18A 0.0517219632264389 -KRTAP11-1 0.00426873037466338 -KRTAP8-1 0.0205124822628118 -MRAP 0.0106384158711261 -HUNK 0.997271074532227 -KRTAP19-8 0.00748612331236648 -KRTAP21-2 0.250319144790592 -KRTAP21-1 0.485522901924314 -KRTAP20-2 0.137405132942761 -SCAF4 0.999999693301169 -TCP10L 0.00191361363927237 -SOD1 0.442188723698817 -C21orf59 0.000141358025835822 -MRPS6 0.136243672723326 -OLIG1 0.119038216281687 -CRYZL1 0.0906156756788058 -DNAJC28 2.51142673645981e-07 -IL10RB 0.000334787198614454 -TMEM50B 0.298982340705241 -IFNAR1 0.000620329691645639 -SON 0.999999910132538 -IFNGR2 0.881281108961234 -SLC5A3 0.849464749953749 -DONSON 4.37159572043293e-05 -PAXBP1 0.999970426365576 -GART 0.0630561344999445 -IFNAR2 0.00506602558328155 -C21orf62 0.0576278443415897 -ITSN1 0.999999973635691 -OLIG2 0.203764106544774 -ATP5O 0.434076662830685 -RIPPLY3 2.12280673958272e-06 -SMIM11 0.556682787500196 -CBR1 0.00646220210275156 -RCAN1 0.557669158298526 -SETD4 2.5473165547071e-12 -CLIC6 0.00053522352566409 -MORC3 0.999874192317744 -CBR3 8.02768561586313e-06 -KCNE1 0.00418613539147309 -CLDN14 0.000330686692861074 -KCNE2 0.0010184057784747 -DOPEY2 9.61164900781145e-08 -SIM2 0.178825368644501 -AP000695.1 0.000465245334005105 -CHAF1B 0.536697059074058 -HLCS 0.486548323659441 -RUNX1 0.449323606506754 -KCNJ6 0.812451385393419 -ETS2 0.993350130351238 -KCNJ15 0.15046203852881 -DSCR4 0.00131700519306661 -PSMG1 0.0129744173088997 -DSCR3 0.50591897208566 -WRB 0.0591591068672799 -PIGP 0.000394928585804372 -B3GALT5 0.00358396705517524 -BRWD1 0.999999462325348 -DYRK1A 0.999584541726647 -LCA5L 1.90936191141484e-06 -ERG 0.968344473919641 -IGSF5 2.32102326951294e-11 -PCP4 0.0751039149902311 -HMGN1 0.425365462309957 -TTC3 5.39422630787731e-20 -SH3BGR 0.00035235304533994 -UMODL1 2.27450532319603e-24 -TFF2 0.000144473936588797 -PRDM15 0.753744615224627 -TMPRSS2 0.062064327980345 -ABCG1 0.358875895364322 -BACE2 0.952644808591658 -DSCAM 0.99999999983846 -MX2 7.0102685339018e-08 -MX1 4.50420824011591e-09 -C21orf128 0.0296211123425033 -RIPK4 0.00120659621680067 -ZBTB21 0.986130663064607 -C2CD2 0.0600282483313238 -FAM3B 1.17773609454313e-06 -UBASH3A 3.97256626321349e-07 -TMPRSS3 4.03368854895368e-05 -TFF3 0.0856870201255524 -SLC37A1 0.028612841735564 -TFF1 0.00630356016196767 -RSPH1 0.000210570388617988 -RRP1B 0.0368184350731871 -SIK1 0.993830465042737 -CRYAA 0.521020324207416 -CSTB 0.000132259411422296 -RRP1 0.00185041139129439 -U2AF1 0.986595630278487 -TRAPPC10 0.999998954037007 -C21orf33 0.00117212805596081 -PKNOX1 0.98655084446177 -ICOSLG 0.0425484518847542 -AGPAT3 0.994454771437506 -HSF2BP 6.3650365720359e-10 -NDUFV3 4.32515643200341e-09 -PDXK 0.984648172841486 -PWP2 0.875422848057892 -PDE9A 0.0020173637864315 -CBS 0.00677205373062702 -WDR4 5.33772408317289e-06 -KRTAP10-3 0.0652460719862998 -KRTAP10-8 5.20734368242563e-06 -AIRE 1.55048193646196e-06 -KRTAP10-7 0.00759405487600206 -TSPEAR 1.87288813996797e-10 -TRPM2 3.36526227253837e-25 -PFKL 3.68287250532775e-10 -KRTAP10-11 0.00039520835434146 -DNMT3L 1.25678875267047e-06 -KRTAP10-2 0.0170721058222492 -KRTAP10-10 2.63978765634477e-05 -KRTAP10-5 8.24781964419107e-05 -KRTAP10-1 0.106027011173101 -KRTAP10-9 0.44279392690144 -KRTAP10-6 1.55311497446653e-05 -C21orf2 0.0135303834414265 -KRTAP10-4 0.00183072306913658 -LRRC3 0.00645694832852908 -ADARB1 0.843939346822973 -ITGB2 3.87638472937311e-05 -COL6A1 0.999994534766207 -POFUT2 0.0108408721953063 -FAM207A 0.0395817647359521 -PTTG1IP 0.266254067406983 -SUMO3 0.31249615499247 -KRTAP12-2 5.57611036071947e-05 -KRTAP10-12 0.114715057789637 -KRTAP12-3 0.146058957278522 -UBE2G2 0.247416499355309 -SLC19A1 0.0123881003346845 -KRTAP12-4 0.00279068688913577 -PCBP3 0.980315404815837 -COL18A1 1.23766303264373e-05 -COL6A2 0.00213375739441823 -KRTAP12-1 0.0251971191873409 -YBEY 0.000726358489255345 -MCM3AP 0.837366650314123 -DIP2A 0.726099073608303 -S100B 0.181611099130469 -PCNT 4.17814442415305e-38 -SPATC1L 3.78329490177049e-06 -LSS 0.000604838176127229 -PRMT2 0.751420208347907 -C21orf58 3.74077237894162e-09 -FTCD 4.30129998812761e-08 -USP18 0.392598704975479 -BID 2.67829587669192e-07 -PEX26 0.43597330189852 -IL17RA 0.119417929909631 -XKR3 0.00085455981009688 -CCT8L2 0.00183334326021415 -MICAL3 0.999997947705208 -SLC25A18 0.0110646872211993 -BCL2L13 0.070274402040073 -CECR5 2.10878542968906e-08 -TUBA8 0.00322749700590359 -CECR1 5.25343969690408e-05 -ATP6V1E1 0.882471622602822 -OR11H1 0.769596446937656 -GAB4 6.04411095952199e-06 -TSSK2 0.0041565292806896 -DGCR2 0.00109593805086936 -CLTCL1 1.24075567829919e-26 -TBX1 0.983396787766063 -GSC2 0.0371862070942536 -CLDN5 0.74051961882886 -SEPT5 0.914631982551485 -DGCR6 7.62101542352864e-07 -HIRA 0.999998171154956 -GP1BB 0.101120792076755 -C22orf29 5.80709519233968e-06 -SLC25A1 0.633538572578213 -PRODH 4.75363149716848e-06 -UFD1L 0.997407162576096 -DGCR14 9.97852446509117e-06 -TXNRD2 1.06916304756314e-08 -CDC45 0.0691043589822534 -MRPL40 0.0200816914982677 -C22orf39 3.69004562054558e-07 -GNB1L 0.00126345233746083 -DGCR6L 0.128574000583518 -PI4KA 0.000804073363471932 -ARVCF 8.21839210300339e-07 -RANBP1 0.336215103625086 -TRMT2A 1.30587511080313e-05 -DGCR8 0.999895838044823 -SERPIND1 2.79554255070019e-05 -COMT 0.000846657832012693 -ZNF74 0.00035587805447844 -KLHL22 0.702611047042905 -AIFM3 1.95828310839448e-10 -ZDHHC8 0.988991095834612 -RTN4R 0.526443417823064 -TANGO2 4.22237843707503e-06 -CRKL 0.163453647364194 -SNAP29 0.151662054198404 -MED15 0.960808622998609 -VPREB1 0.00134358993682976 -THAP7 0.0293278546639812 -LZTR1 3.38323005538586e-52 -GGT2 0.804816509817502 -PPIL2 0.0274929870468308 -YDJC 0.00215046445208775 -PPM1F 0.000267470134913572 -CCDC116 3.97673357670938e-05 -SLC7A4 0.000100465628178791 -HIC2 0.947187316266396 -TOP3B 0.114528012617576 -SDF2L1 0.0542960896755155 -YPEL1 0.224430518088329 -P2RX6 1.87852665747002e-07 -MAPK1 0.981866085911696 -UBE2L3 0.778719690860565 -PRAME 0.000838035154210176 -BCR 0.999967224797783 -MMP11 6.59354935689745e-05 -ZNF280A 1.33609532462502e-08 -C22orf43 4.72106210625553e-07 -IGLL1 0.0171677422605345 -ZNF280B 0.283015680343504 -GNAZ 0.886293663993377 -RGL4 2.32929497563318e-10 -CHCHD10 0.000132412414863812 -RTDR1 0.00351040242368236 -SMARCB1 0.996807633610163 -C22orf15 0.0813466462823027 -GGTLC2 0.000421521541315101 -AP000349.1 0.00339932967002051 -RAB36 1.44185655300034e-05 -ZNF70 0.168320381851445 -VPREB3 0.0161485671370314 -FAM211B 1.90288538061698e-11 -SUSD2 1.32605754184724e-10 -GGT1 0.676974716705773 -DDT 0.412925623752845 -SLC2A11 5.45933694484048e-12 -UPB1 1.85086913944901e-07 -PIWIL3 9.86575487560156e-26 -AP000350.4 0.37757496797728 -GGT5 1.39303239383364e-05 -MIF 0.0324842227823062 -CABIN1 8.54365661226281e-08 -GSTT2 0.2267348291534 -DERL3 0.000238218108055327 -GSTT1 0.00166897825306788 -GUCD1 0.0166878645052519 -GSTT2B 0.520153497085797 -DDTL 0.41672757218518 -SNRPD3 0.877845312096731 -ADORA2A 0.331624356227667 -SPECC1L 0.993395147293948 -SEZ6L 0.928831047449245 -ASPHD2 0.526013415728331 -HPS4 1.40159466155322e-05 -TFIP11 1.96788418936719e-06 -CRYBB2 0.583885170755227 -SGSM1 0.977248922647981 -TMEM211 0.216382272106154 -CRYBA4 6.69435979827333e-08 -CRYBB1 0.000388650496371835 -ADRBK2 0.793703982799154 -LRP5L 3.87405123217097e-11 -CRYBB3 4.07383009403585e-10 -CHEK2 1.18301128459806e-15 -TPST2 0.599488923277404 -PITPNB 0.974445019359892 -MYO18B 2.61207132683228e-15 -SRRD 1.58605385256121e-06 -HSCB 0.000141919775298349 -C22orf31 2.31877898310653e-05 -NIPSNAP1 0.979278956519241 -RHBDD3 2.03589668904127e-05 -NEFH 0.00126104058830359 -RFPL1 0.00732601016899253 -EMID1 0.0397077266512435 -XBP1 0.203748476125444 -KREMEN1 0.372971655730604 -AP1B1 0.99158312872111 -RASL10A 0.678377624022204 -GAS2L1 0.700430403558868 -UQCR10 0.149717438688814 -ZMAT5 0.000193622547453497 -THOC5 0.000462815234823358 -NF2 0.999923343294104 -CCDC117 0.619564484902431 -CABP7 0.89963339213873 -ZNRF3 0.995712185612616 -EWSR1 0.998559249387376 -SLC35E4 0.032252529013455 -RNF215 0.000386646001224259 -DUSP18 0.0618037276513494 -TBC1D10A 0.975495334596957 -MTMR3 0.994951612157603 -SEC14L2 4.31488873660089e-05 -PES1 0.655113488767418 -TCN2 0.0222895531737769 -MTFP1 0.316869739233121 -LIF 0.774442435814619 -SEC14L4 5.59567327026563e-05 -SEC14L3 4.21057781805564e-18 -GATSL3 0.453126498226772 -GAL3ST1 0.379107293050681 -CCDC157 2.42416018108272e-15 -ASCC2 0.178384955691887 -SEC14L6 0.0459161840126631 -OSM 0.397920808045078 -SF3A1 0.994075395519488 -HORMAD2 3.44849609468045e-05 -C22orf24 1.2513284860103e-05 -EIF4ENIF1 0.999689053765957 -SMTN 0.755974257454824 -MORC2 0.999967480342235 -PLA2G3 1.13934377005578e-08 -DRG1 0.953443602675955 -LIMK2 0.00844040082440469 -SFI1 5.98724844744369e-25 -INPP5J 6.4309573309253e-12 -OSBP2 0.0361487444611796 -PISD 0.840252300973845 -SELM 6.37196036891659e-07 -RNF185 0.679395060761065 -YWHAH 0.555591182061994 -PRR14L 0.984999166925525 -DEPDC5 0.99999993402596 -SLC5A1 0.00803119583011728 -PATZ1 0.992716044132751 -PIK3IP1 0.0597509759336671 -RTCB 0.0587292330087026 -TOM1 6.77746945347432e-06 -MCM5 0.56369250698601 -BPIFC 3.12823000785522e-06 -MB 0.337840557859152 -SYN3 0.577812323529965 -HMOX1 0.000641360507953024 -TIMP3 0.112088669149861 -C22orf42 1.42223733805271e-06 -FBXO7 0.0987224228672443 -RFPL2 7.3761565774224e-05 -APOL6 0.00070410760470988 -HMGXB4 0.218813415259936 -RASD2 0.716620456976745 -LARGE 0.958481011778369 -RFPL3 0.00015844316199715 -ISX 0.00018915120761652 -RFPL3S 0.415441821624395 -SLC5A4 2.60144685908226e-13 -TXN2 0.00554567802065394 -NCF4 7.89904665161403e-06 -APOL5 1.00622472238021e-08 -TMPRSS6 3.34440581613057e-06 -MYH9 0.999999999912023 -APOL2 0.000139187047584769 -KCTD17 0.0511169926059515 -IFT27 0.000880890777082489 -APOL1 3.75078410438376e-08 -APOL4 9.93032452582808e-05 -CACNG2 0.958056003336912 -CSF2RB 0.00186665245080198 -MPST 0.00677646845635564 -PVALB 0.0678701921991012 -APOL3 2.87221559841753e-05 -EIF3D 0.994221961457999 -RBFOX2 0.993206874904073 -TEX33 0.000322690552250852 -TST 0.000731843487954778 -FOXRED2 0.00691546683994862 -SH3BP1 0.152682967806694 -GCAT 7.76096763410133e-06 -GALR3 0.0231534228966913 -CARD10 0.10891986887678 -IL2RB 0.986756575573638 -C1QTNF6 0.0237893847295441 -SSTR3 0.0372243594214985 -ANKRD54 0.0153084731551182 -RAC2 0.873092320404228 -ELFN2 0.84901528665725 -CDC42EP1 1.05708648523099e-05 -PDXP 0.0427153489302202 -MFNG 1.32485976962964e-07 -GGA1 0.999441827375042 -TRIOBP 8.94617457135198e-13 -H1F0 0.154802582065257 -NOL12 0.0905536976948761 -CYTH4 0.572494881980175 -LGALS2 0.0146890321396129 -LGALS1 0.00463689761502241 -MICALL1 0.000381388681523539 -KDELR3 2.25894610398846e-06 -TMEM184B 0.878340975684015 -MAFF 0.042201121909027 -SLC16A8 0.11016481897003 -CBY1 0.0274301810457834 -TOMM22 0.785832960017485 -KCNJ4 0.825953321303081 -DMC1 0.180759800545053 -CSNK1E 0.967319235295747 -C22orf23 2.51126071127562e-06 -EIF3L 0.93881361379477 -BAIAP2L2 0.000100357855733205 -PLA2G6 2.66040412130891e-08 -POLR2F 0.652869046375363 -JOSD1 0.319904564982739 -SOX10 0.91309785132116 -GTPBP1 0.996188561880383 -PICK1 0.555069205475041 -CBX7 0.837455380362367 -MGAT3 0.460179519269915 -APOBEC3F 0.0139601925830727 -SYNGR1 0.581490268493249 -RPL3 0.994251970706247 -DNAL4 0.32342202050456 -APOBEC3D 2.35516694213337e-05 -APOBEC3A 0.22634791867463 -APOBEC3B 2.50835391870874e-05 -APOBEC3G 1.47030454091374e-06 -APOBEC3C 0.0926245609517721 -TAB1 0.00399581121095206 -CBX6 0.610925095502502 -PDGFB 0.966288095427289 -MIEF1 0.0628938325307641 -APOBEC3H 0.637623187325877 -SUN2 2.40833189817119e-07 -RPS19BP1 0.00589798441146116 -ATF4 0.411468430246377 -CACNA1I 0.999998893513202 -GRAP2 0.101871595396695 -MKL1 0.54032417291881 -TEF 0.421035621263218 -TOB2 0.703190337105161 -ENTHD1 3.66824019270564e-06 -FAM83F 0.000400741432694423 -DNAJB7 2.09351234250952e-11 -L3MBTL2 0.0130280434479328 -RANGAP1 0.132718719795843 -RBX1 0.940246880165137 -SLC25A17 0.0241848435983763 -XPNPEP3 8.88349445351575e-06 -CHADL 0.080813456311772 -ADSL 0.000212575309664513 -SGSM3 1.00601271154805e-06 -TNRC6B 0.999999802750713 -EP300 0.999999999999484 -ST13 0.659423623669509 -ZC3H7B 0.990761551309557 -MCHR1 0.00114839274760266 -PHF5A 0.849500693094142 -ACO2 0.454377775083461 -CSDC2 0.0798035156205298 -CENPM 0.213983560470949 -SREBF2 0.996271601286458 -POLR3H 0.00200710591580713 -NHP2L1 0.710585253957818 -NDUFA6 0.00325949355170513 -SMDT1 0.163350133143623 -PMM1 0.000159924654790979 -SEPT3 0.0692482029063671 -FAM109B 0.000109676972120869 -WBP2NL 2.07233062858540e-09 -MEI1 1.21592363387865e-08 -CCDC134 0.000741172780034662 -NAGA 2.01989868135176e-06 -TNFRSF13C 0.641054687513937 -DESI1 0.0937224778463612 -XRCC6 0.996855852811598 -RRP7A 0.00237295900903576 -TTLL1 0.00563299514240826 -CYB5R3 0.210867104328179 -PACSIN2 0.270395757339363 -EFCAB6 4.56556650101554e-19 -TSPO 0.021753056615385 -TCF20 0.999977934276122 -A4GALT 0.111598718084493 -SULT4A1 0.968128304940117 -SCUBE1 0.960878305718201 -BIK 2.5374926599392e-05 -MPPED1 0.283449525180926 -MCAT 0.00012348797323243 -ATP5L2 0.166948561167818 -ARFGAP3 2.27855257372515e-06 -NFAM1 0.0260796215955231 -TTLL12 1.99091364629049e-15 -CYP2D6 9.22645796999686e-10 -POLDIP3 0.832319946565907 -SERHL2 1.16697862264791e-11 -KIAA0930 0.815289886693543 -PNPLA3 0.000103859216104925 -UPK3A 1.41130198024748e-07 -SAMM50 0.000727114523857838 -FAM118A 0.591868565334658 -PNPLA5 9.38341355316044e-07 -KIAA1644 0.676861238307606 -NUP50 0.238540627987742 -PARVB 1.17140003331479e-12 -PRR5 0.972989444687975 -FBLN1 0.852457932605284 -RIBC2 3.91231648417033e-07 -ATXN10 0.745162923489296 -PARVG 0.012022450286735 -SMC1B 0.986578245527667 -LDOC1L 0.142833061438218 -PHF21B 0.914020956210128 -CELSR1 0.999990747432086 -ZBED4 0.989506768385479 -GTSE1 6.90346708786844e-06 -PPARA 0.463829864293015 -ALG12 0.00788198257903734 -CERK 1.60283834611446e-05 -GRAMD4 0.999791413435688 -WNT7B 0.000391539815358636 -FAM19A5 0.310031381590844 -BRD1 0.994534773397455 -CDPF1 0.00113893126522692 -PKDREJ 4.71093052032008e-20 -TBC1D22A 0.957287977622822 -TRMU 5.75923545642307e-09 -TTC38 5.69518522496362e-10 -C22orf26 0.0358460216092574 -CRELD2 4.95812176033358e-08 -SBF1 0.690538813887376 -TUBGCP6 5.08953781746856e-19 -MAPK12 0.0136200575011183 -MIOX 4.60477630861768e-12 -MOV10L1 5.748157114955e-10 -IL17REL 0.327459012314709 -DENND6B 0.0310203476755261 -PPP6R2 0.718789474101901 -PLXNB2 0.992862470603308 -PIM3 0.937120654328565 -NCAPH2 0.652832372947923 -MLC1 5.02796269549306e-05 -ADM2 0.0153000381093707 -PANX2 0.0149007665484345 -SELO 5.81141018793982e-15 -MAPK11 0.472036682263674 -HDAC10 3.2788087078515e-12 -TRABD 0.931187268796145 -ARSA 8.51321818711031e-08 -CPT1B 2.03406716145902e-09 -ACR 0.0154598896615065 -SHANK3 0.999839619981909 -RABL2B 0.765589454248129 -CHKB 0.000644971493148547 -ODF3B 0.00916745822195973 -TYMP 0.000465858647806756 -SCO2 0.000101907145142781 -MAPK8IP2 0.997524779751463 -KLHDC7B 0.000573066841521424 -ARSF 4.0838492730915e-07 -DHRSX 0.00645955012200972 -XG 0.0136799820520379 -CSF2RA 0.00186657626375054 -ASMT 2.57526101207604e-13 -CD99 0.21761289792797 -ASMTL 1.21964663235068e-05 -SHOX 0.738457610429217 -AKAP17A 0.713632077782215 -IL3RA 1.10372786819782e-12 -ARSH 0.00160023102984739 -ARSE 0.120625324518616 -CRLF2 0.00278020670397447 -ZBED1 0.00183309311469201 -PPP2R3B 1.71421301526223e-09 -ARSD 0.292872844082226 -P2RY8 0.0128441170894152 -PLCXD1 1.56642202426473e-12 -GYG2 1.70507761922303e-05 -SLC25A6 0.0669196984002589 -KAL1 0.938574322654335 -VCX2 0.103436662210244 -FAM9A 2.85647915187388e-05 -FAM9B 9.496950290472e-05 -MXRA5 0.376484079502154 -VCX3A 0.506384677528491 -PRKX 0.221428117908246 -VCX3B 0.221349599841616 -SHROOM2 0.00694500211668264 -WWC3 0.999632960749509 -HDHD1 0.259847001873831 -GPR143 0.672222023530739 -NLGN4X 0.932298559009719 -PNPLA4 0.0110685080808277 -VCX 0.577712382787133 -TBL1X 0.998500302780111 -STS 0.981414315787146 -CLCN4 0.988787920457612 -TMSB4X 0.485751296983389 -PRPS2 0.922707345456536 -HCCS 0.950550391243934 -ATXN3L 4.31613107316262e-09 -TLR7 0.872917548986338 -MID1 0.500724578255505 -GLRA2 0.908587632299454 -TCEANC 0.0963544550376469 -OFD1 0.982887661849247 -GPM6B 0.494053306674971 -AMELX 0.187525654901344 -ARHGAP6 0.991844364940163 -GEMIN8 0.906251194519291 -FRMPD4 0.997190828986364 -FAM9C 5.54037336232307e-05 -MSL3 0.945646874379395 -TLR8 0.931026133439482 -TRAPPC2 0.624929855815672 -EGFL6 2.66228154128096e-08 -RAB9A 0.779010976914761 -ASB11 0.155409012919734 -PIGA 0.916789461610083 -FIGF 0.0109063275472999 -CTPS2 0.433684610695428 -ASB9 0.887238949040102 -S100G 0.141285757222525 -RBBP7 0.983294257742315 -SYAP1 0.502110067754607 -BMX 0.583862245065186 -GRPR 0.138137201690617 -FANCB 0.988393525012567 -CA5B 0.00331242978898846 -TXLNG 0.992209565527669 -AP1S2 0.792611169503459 -TMEM27 0.00310804463799565 -ZRSR2 0.998381924853728 -ACE2 0.999070360837032 -MOSPD2 0.992713930090269 -PIR 1.15732341465005e-05 -MAGEB17 0.0284362734443786 -RS1 0.892912340131916 -CDKL5 0.997790054805334 -EIF1AX 0.881572170128827 -BEND2 0.348216589536089 -REPS2 0.968427757558824 -PDHA1 0.99209013913194 -GPR64 0.964168452415728 -CXorf23 0.803897863874202 -SCML2 0.998434048382124 -NHS 0.999461888794772 -PPEF1 0.984407235920156 -CNKSR2 0.999748049373382 -KLHL34 4.42258132212847e-05 -RAI2 0.298853666814438 -SCML1 0.948610392136383 -SH3KBP1 0.998643127661381 -RPS6KA3 0.999905699416843 -MAP7D2 0.555948304937886 -MAP3K15 1.01372441429332e-28 -PHKA2 0.908082279776674 -CXorf58 0.000356507184657727 -ZNF645 0.016465619897393 -POLA1 0.999999524777767 -YY2 0.383414002511684 -PTCHD1 0.947053078709569 -EIF2S3 0.916323958431386 -PRDX4 0.281507844531997 -SMPX 0.593774441660937 -DDX53 0.825398952735036 -ZFX 0.986133449821669 -SMS 0.921460277265947 -MBTPS2 0.94019932230867 -PHEX 0.999645685351575 -APOO 0.754113198235746 -PCYT1B 0.944740314394971 -SAT1 0.811595278666733 -ACOT9 1.90917714279274e-05 -KLHL15 0.954395214388248 -ARX 0.75306908332634 -PDK3 0.879275520248217 -TMEM47 0.6410239240686 -MAGEB6 0.386744087189912 -TAB3 0.921511503588616 -MAGEB4 0.25505460782301 -MAGEB18 0.040371281052756 -MAGEB2 0.00647981734401363 -CXorf21 0.255813631360974 -DMD 0.999999999803525 -DCAF8L2 0.575393469012494 -DCAF8L1 0.119165931149828 -MAGEB5 0.114589765510266 -FAM47A 0.748400418346306 -NR0B1 0.791995494731047 -IL1RAPL1 0.996893678356441 -FTHL17 0.000467382833595725 -GK 0.9032586495572 -MAGEB1 0.0701338980445544 -MAGEB10 0.710701863627324 -FAM47B 0.000117993061079711 -MAGEB3 0.66135267930598 -ATP6AP2 0.785047267980171 -DYNLT3 0.650718442302593 -TM4SF2 0.90134494428007 -RPGR 0.997857546203891 -SYTL5 0.0644886545028385 -BCOR 0.999945621390125 -MAGEB16 0.00166368220637961 -CHDC2 0.309200591787143 -XK 0.869601995997447 -OTC 0.981017899946665 -CYBB 0.99769789816162 -MID1IP1 0.489439187483796 -LANCL3 0.522828102456292 -FAM47C 0.0577973111457409 -CXorf22 0.904576724456984 -CXorf27 0.152953477046134 -PRRG1 0.335254587436665 -SRPX 0.00848262097838311 -TSPAN7 0.86995013142945 -CASK 0.999885704504806 -MED14 0.999999382308837 -MAOB 0.970339617070938 -KRBOX4 0.377824215699539 -DDX3X 0.99893006535012 -MAOA 0.993222490508762 -USP9X 0.999999999976444 -GPR82 0.00101851085267785 -KDM6A 0.999987120523081 -CHST7 0.0985193527095849 -SLC9A7 0.953699986952486 -FUNDC1 0.440692340205304 -NDP 0.64382884136087 -NYX 0.0624131502401644 -EFHC2 0.941723124383347 -DUSP21 0.00358650089236117 -GPR34 0.457038660900044 -ZNF674 0.00427494121454892 -CXorf38 0.00516358433779017 -CXorf36 0.00760359252342126 -USP11 0.998323456750043 -ZNF81 0.303589182435344 -ZNF182 0.856542477213403 -ZNF41 0.00138968236818729 -TIMP1 0.766877187652718 -UBA1 0.999990741817615 -PHF16 0.995483944752669 -SYN1 0.879529753332511 -ZNF157 8.04449374208541e-07 -ELK1 0.756057873787214 -UXT 0.836315941423648 -ARAF 0.618988518165058 -NDUFB11 0.750858556039213 -RGN 0.0416453375909365 -CDK16 0.995702615689421 -RP2 0.851505576518184 -RBM10 0.999912181208767 -CFP 0.944168669031185 -SSX3 0.146323758317065 -GATA1 0.837375784159948 -TBC1D25 0.711973350325596 -SSX5 2.33013753613682e-07 -SSX4 0.443294513598317 -EBP 0.858629818405411 -RBM3 0.700968680872873 -FTSJ1 0.96163278031456 -ZNF630 0.00223023467855748 -SSX1 6.95390585589371e-28 -SSX4B 0.47431959897204 -PORCN 0.995196052430872 -WAS 0.991202084335487 -GLOD5 0.0460777312018374 -WDR13 0.940346118992748 -SUV39H1 0.936945044155794 -SLC38A5 0.976708481576873 -TIMM17B 0.826908628916093 -PIM2 0.894760123149801 -MAGIX 0.0035921864657483 -GPKOW 0.979573126517589 -KCND1 0.447025940564966 -PRICKLE3 0.15265646111407 -WDR45 0.965710816064405 -PLP2 0.112369204580837 -PCSK1N 0.444049066588872 -GRIPAP1 0.996933311471836 -TFE3 0.973742209543687 -SLC35A2 0.780526258513 -OTUD5 0.97654856924968 -PQBP1 0.59284411367679 -HDAC6 0.99992079805848 -SYP 0.611984996510125 -PRAF2 0.65127647545626 -AF196779.12 0.901680436585852 -CCDC120 0.691311336063518 -ERAS 0.51999564841992 -CACNA1F 0.873703604496026 -GAGE10 0.00111994818700601 -GAGE2D 0.402977937434793 -GAGE1 0.438832810615359 -CCDC22 0.995198908362386 -FOXP3 0.948721767538971 -PPP1R3F 0.00474942926878046 -GAGE12J 0.0235889056454509 -GSPT2 0.904748870176252 -PAGE4 0.648195518447356 -CCNB3 0.57088694342555 -PAGE1 0.389289495504708 -AKAP4 0.984377750020385 -NUDT11 0.699091254686775 -USP27X 0.592784999490721 -SHROOM4 0.997425924732999 -CLCN5 0.9942416657125 -BMP15 0.0535439236113694 -CXorf67 0.868926865860632 -MAGED1 0.982074597200181 -SSX7 7.6817804736366e-05 -XAGE5 0.000119391381360832 -IQSEC2 0.975390479204391 -RIBC1 0.966259507412859 -TSPYL2 0.874635827562653 -SPANXN5 0.500966160239482 -HUWE1 0.999999999999995 -HSD17B10 0.886870267829669 -GPR173 0.678239841602563 -KDM5C 0.997842569241018 -SMC1A 0.999988493720044 -XAGE3 0.0885803035251833 -APEX2 0.889124800888643 -TSR2 0.760610428612814 -PFKFB1 0.000222069886004765 -WNK3 0.99999836654063 -PAGE2B 0.203304959214182 -PHF8 0.998239852588149 -FAM104B 0.00870993932895896 -ITIH6 9.88847044832986e-11 -PAGE5 0.0712543126666454 -FGD1 0.972835312099674 -PAGE3 0.050523543150726 -MAGED2 0.989729719490781 -USP51 0.912300847179826 -FAM120C 0.973037034571628 -TRO 0.00166962000566844 -ALAS2 0.970654597578417 -PAGE2 0.201620359247133 -GNL3L 0.991954332117903 -MAGEH1 0.338067798966747 -MSN 0.993557145802077 -MTMR8 1.33537060083682e-11 -SPIN2B 0.620083821072506 -ARHGEF9 0.983065394323285 -ZC3H12B 0.972148733086522 -SPIN2A 0.220661420438701 -AMER1 0.953441252971679 -FOXR2 0.00256624410589497 -ZXDA 0.00521089549915299 -KLF8 0.027862422377185 -LAS1L 0.892095595186022 -FAAH2 2.45580805455636e-17 -ASB12 1.61933516638744e-05 -SPIN3 0.674771547942128 -ZXDB 0.842955569355446 -RRAGB 0.893169858978643 -SPIN4 0.725861947192611 -ZC4H2 0.825852220957158 -UBQLN2 0.804317268481036 -ARR3 0.137242313191003 -DGAT2L6 3.36553042993953e-08 -AWAT2 0.603147993992504 -OTUD6A 0.573824004405944 -AWAT1 0.0150959038854437 -P2RY4 0.340711070430522 -IGBP1 0.933825157525953 -EFNB1 0.781251723198181 -RAB41 0.0121821534238742 -EDA 0.922511722867168 -OPHN1 0.999448414550568 -VSIG4 0.000110511267388792 -EDA2R 0.136305948867017 -PJA1 0.894042634793692 -FAM155B 0.870611038142857 -HEPH 0.0095892677408694 -YIPF6 0.571047385335828 -STARD8 0.0358308690371062 -PDZD11 0.813638005471866 -AR 0.99490980991855 -SNX12 0.695492431895904 -CXorf65 0.905102153264171 -ZMYM3 0.999966815937562 -TAF1 0.999999755773455 -FOXO4 0.861869126511084 -TEX11 0.999964221357823 -CXCR3 0.257493403151663 -MED12 0.999999998786565 -NLGN3 0.896227168388092 -NHSL2 0.812282091450701 -KIF4A 0.999968444608122 -SLC7A3 0.967794266173169 -IL2RG 0.957764471265316 -NONO 0.993946500321612 -OGT 0.999947206587498 -GDPD2 0.116236323908697 -ITGB1BP2 0.000383159415631921 -GJB1 0.65980172421035 -ACRC 0.982862105708704 -DLG3 0.999544464508013 -HDAC8 0.922707724679457 -NAP1L2 0.791659153831853 -PHKA1 0.881287038362445 -CHIC1 0.684233596256066 -RLIM 0.99177291457597 -ZCCHC13 0.000210272056556787 -CDX4 0.0135584478091119 -RGAG4 0.0151977798601472 -RPS4X 0.886149633662523 -SLC16A2 0.934351642887307 -PABPC1L2A 0.343427413800262 -KIAA2022 0.950542378844954 -ABCB7 0.995047822845297 -ERCC6L 0.986827393517475 -CITED1 0.0454033926143545 -DMRTC1 0.43895356043987 -PIN4 0.646369632596627 -CYSLTR1 0.00432046248282026 -ATRX 0.99999998229899 -GPR174 0.888101966399909 -ZDHHC15 0.896641058029422 -FAM46D 0.67476351159847 -TBX22 0.974752070043244 -COX7B 0.656619051877437 -ITM2A 0.84271835183677 -MAGEE1 0.699601223364713 -TAF9B 0.000410982863235518 -PBDC1 0.84546441452731 -ZCCHC5 7.22552233533475e-09 -MAGEE2 1.52942226417517e-08 -UPRT 0.814813817299778 -P2RY10 0.690389561601064 -ATP7A 0.999634377087713 -PGAM4 0.28327008535875 -PGK1 0.971138951857199 -LPAR4 0.0430359788704934 -MAGT1 0.887373875952856 -ZNF711 0.989393563505584 -CPXCR1 0.0774718472474688 -PCDH11X 0.925742124901504 -POF1B 0.000181225035292492 -RPS6KA6 0.744166833872825 -BRWD3 0.999999995988904 -HDX 0.517074458559921 -CYLC1 0.606280835629087 -PABPC5 0.362703122825983 -DACH2 0.859033207333493 -POU3F4 0.720490939213332 -HMGN5 0.326715650017622 -NAP1L3 0.411770225900925 -KLHL4 0.872766936888335 -TGIF2LX 0.592887022382807 -CHM 0.997851014105269 -FAM133A 0.659793341226144 -SATL1 6.50493662540814e-12 -SH3BGRL 0.281416437305486 -APOOL 0.86631270153769 -CSTF2 0.305798340225873 -DIAPH2 0.999119100290442 -RPL36A 0.79320686438897 -TNMD 0.816440948853997 -PCDH19 0.977158512715513 -CENPI 0.996692510858043 -NOX1 0.000386451550813002 -DRP2 0.00940021508163857 -XKRX 0.000300218069787513 -TAF7L 0.843722648897641 -TMEM35 0.648723791041668 -TIMM8A 0.605876721088247 -GLA 0.985045990572971 -SRPX2 0.96252939282245 -ARL13A 0.00753187853335742 -TRMT2B 0.000100904990487132 -SYTL4 0.0246065524770759 -BTK 0.999563220319725 -TSPAN6 0.0282021832612146 -RPA4 0.273955521172468 -ARMCX6 0.259563477582888 -ARMCX2 0.730479736461147 -TMSB15A 0.482094888097074 -TCEAL6 0.650796969830344 -NXF5 0.00420784516244663 -BEX5 0.0163388827467428 -ZMAT1 0.0639505147007786 -TCEAL2 0.679466606366515 -ARMCX5 0.550666214123304 -GPRASP1 0.501518109194796 -GPRASP2 0.498014765173916 -ARMCX1 0.395796527068072 -ARMCX3 0.249589238901881 -HNRNPH2 0.868284240433363 -NXF2B 0.760751147925074 -BHLHB9 0.370497960484996 -NXF3 0.00853781286314966 -PLP1 0.90295851162582 -BEX1 0.572647843193304 -TMSB15B 0.481871220044893 -RAB40AL 0.306490452326046 -TCEAL7 0.45019439360782 -BEX2 0.592514905495088 -BEX4 0.673985987212613 -NGFRAP1 0.254415485454097 -TMEM31 0.000256765988767014 -TCEAL8 0.483466805907495 -MORF4L2 0.636394719546278 -TCEAL3 0.603339069922021 -RAB40A 0.0666088196899615 -RAB9B 0.618182540762696 -TCEAL5 0.666797567268795 -TCEAL1 0.488641003961424 -GLRA4 4.1690448487125e-05 -WBP5 0.152692408054898 -TCEAL4 0.683649622368237 -NUP62CL 0.00439455220578126 -SERPINA7 0.132498719622418 -TBC1D8B 1.87465336440428e-05 -NRK 0.763369951142185 -TEX13A 0.00748148856358932 -FAM199X 0.926151027548092 -MORC4 0.993467674426918 -RNF128 0.768185327415573 -SLC25A53 0.101916710137974 -RIPPLY1 0.00780581933403429 -MUM1L1 0.635560374421233 -PIH1D3 0.814438563515254 -ESX1 0.635809622081592 -RBM41 0.229027554978131 -H2BFWT 0.000863657976086968 -CXorf57 0.187172500066797 -ZCCHC18 0.259266478025309 -CLDN2 0.605106671731875 -H2BFM 0.186492116512072 -IL1RAPL2 0.973379475963156 -FRMPD3 0.910767889845881 -AMMECR1 0.910792997313756 -MID2 0.985076414331709 -GUCY2F 1.51652106018158e-05 -ACSL4 0.995767650409894 -VSIG1 0.00569224987252447 -COL4A6 0.990988266205785 -ATG4A 0.988883246902227 -TMEM164 0.877400449225457 -COL4A5 0.999918348283007 -RGAG1 0.912655333274139 -PRPS1 0.871770724918057 -TEX13B 0.0252280353289702 -KCNE1L 0.00293259907908555 -GNG5P2 0.38481704945863 -IRS4 0.609434374357404 -NCBP2L 0.129669930064103 -NXT2 0.777280517968738 -TSC22D3 0.771725904530727 -PSMD10 0.403603163193442 -AMOT 0.988710202830408 -ALG13 0.997582959543471 -AGTR2 0.0125489579921142 -LRCH2 0.915538078544407 -RP1-241P17.4 0.0410971894979147 -ZCCHC16 0.000561724706329207 -HTR2C 0.0689152859314493 -DCX 0.863196407367064 -KLHL13 0.731977363371556 -PAK3 0.987004716625695 -CAPN6 0.984532250609268 -SLC6A14 0.986093843050961 -IL13RA2 7.6423500941326e-05 -TRPC5 0.993636098486069 -CHRDL1 0.0536284936083553 -CXorf61 0.197556339925321 -LUZP4 0.00022131712724778 -PLS3 0.987821982614245 -LHFPL1 0.0706474575332219 -KIAA1210 0.090793121231346 -UBE2A 0.798143753788149 -NDUFA1 0.580718048098361 -NKAP 0.99551390816983 -UPF3B 0.933766901129754 -PGRMC1 0.622396927421126 -CXorf56 0.925801506265085 -LONRF3 0.15337758764681 -SLC25A43 0.0529550244704604 -SEPT6 0.948998031817981 -WDR44 0.999844185847999 -RPL39 0.620183578382466 -RNF113A 0.822115117314938 -DOCK11 0.998084519073803 -SOWAHD 0.477013933457323 -AKAP14 0.633383828487056 -NKRF 0.955812168094543 -ZCCHC12 0.119948128767607 -SLC25A5 0.857861936540947 -IL13RA1 0.97917160586094 -CT47B1 0.351018055014695 -MCTS1 0.825030345869128 -TMEM255A 0.469576565727473 -RHOXF2 0.592958781555666 -ATP1B4 0.00278062464065032 -LAMP2 0.949783835469488 -ZBTB33 0.893444537354356 -CUL4B 0.99984667801374 -C1GALT1C1 0.688732363511784 -RHOXF1 0.826599973903155 -RHOXF2B 0.576875870835534 -TENM1 0.999995817016826 -SASH3 0.891377604908222 -APLN 0.377456159057367 -XIAP 0.979278387329643 -XPNPEP2 1.69204692246069e-06 -DCAF12L2 0.162975821797611 -GLUD2 0.0713078915604148 -DCAF12L1 0.805163159874703 -THOC2 0.999999919330809 -SH2D1A 0.0826088107933548 -OCRL 0.999918298029263 -SMARCA1 0.999946645897619 -STAG2 0.999999812829939 -GRIA3 0.998653777646266 -ACTRT1 0.0641129356743066 -ZDHHC9 0.88543756379133 -UTP14A 0.999629562781925 -BCORL1 0.981790311640066 -ENOX2 0.00314555069570329 -RAP2C 0.212765647011738 -HS6ST2 0.119199983371802 -AIFM1 0.98463156763188 -RAB33A 0.713538246843134 -GPR119 0.0972559050997455 -ARHGAP36 0.989879513869536 -USP26 0.0104943799173462 -TFDP3 2.30492302905471e-06 -MST4 0.777977751853842 -SLC25A14 0.979191684320595 -ZNF280C 0.992273041974971 -FRMD7 0.910660048623758 -IGSF1 0.996859546493677 -OR13H1 0.0660742164107133 -MBNL3 0.833044765960916 -ELF4 0.611464084402785 -RBMX2 0.772803906392487 -PHF6 0.972400781120067 -FAM122B 0.757591088967366 -DDX26B 0.999847760681818 -GPC3 0.987985908845658 -FAM127A 0.599977362549409 -PLAC1 0.181581258657982 -FAM122C 0.174595943528543 -CCDC160 0.0294628814590456 -ZNF75D 0.000185372038923542 -MOSPD1 0.871382679379854 -FAM127C 0.0255981569872327 -FAM127B 0.0279082981400185 -CXorf48 0.749834815705262 -HPRT1 0.916893576419955 -GPC4 0.948476974816376 -ZNF449 0.871457178959833 -ZIC3 0.822806978202031 -FHL1 0.918480756354643 -FGF13 0.964223639772387 -GPR112 6.78293951437227e-20 -SLC9A6 0.975667933500175 -CD40LG 0.864433712674486 -MCF2 0.943290929446168 -BRS3 0.888203115182751 -HTATSF1 0.973206628172388 -SAGE1 1.63649424965499e-09 -VGLL1 0.449924752430081 -ARHGEF6 0.998212122551167 -MAP7D3 1.12703445169542e-07 -MMGT1 0.408287058485805 -CT45A5 9.3941919310411e-06 -GPR101 0.403512441739383 -F9 0.989580625058095 -RBMX 0.948299697362106 -SLITRK4 0.613671416329225 -LDOC1 0.575480326491493 -MAGEC3 3.2490215491358e-08 -MAGEC2 0.659070496768636 -SPANXN3 0.599707834595902 -SPANXN4 0.107493143744931 -UBE2NL 0.0232238261133411 -ATP11C 0.999724526368115 -CXorf66 0.0183930362804906 -SPANXC 0.000589679869220244 -CDR1 0.0595616098313709 -SPANXN2 2.5965752968708e-05 -SPANXD 0.17781263582521 -TMEM257 0.114594790510145 -IDS 0.97925991869458 -SLITRK2 0.240674715780331 -CXorf40B 0.642796581069124 -MAGEA11 0.59454454715929 -FMR1NB 0.180154210181597 -CD99L2 0.0033413380678308 -MAGEA8 0.238209592292099 -FMR1 0.127197887114845 -MAMLD1 0.840109494669231 -MTM1 0.999351773879244 -TMEM185A 0.0400630742754596 -SPANXN1 0.510405170350752 -CXorf40A 0.61074124217066 -AFF2 0.998760604472339 -MTMR1 0.982418902141347 -GPR50 0.445210115354658 -MAGEA6 0.0941961048529208 -NSDHL 0.940558049226598 -PRRG3 2.0741935360123e-05 -PASD1 0.89707670883228 -MAGEA12 0.700103439261894 -CSAG1 0.000227012408951511 -GABRA3 0.273213945815421 -MAGEA4 0.744658642607292 -CNGA2 0.0815316936822351 -CETN2 0.451744392143999 -HMGB3 0.770459764489854 -VMA21 0.651805241659588 -FATE1 0.0344637295961143 -MAGEA10 0.305621878891437 -GABRQ 0.0100883396988473 -MAGEA3 0.373340458941593 -GABRE 0.000183719411945096 -DUSP9 0.648808512961975 -ZNF185 5.20951973750293e-10 -FAM58A 0.840139167823986 -PNMA3 0.00533780802091748 -ZFP92 0.529624187284892 -BGN 0.916364713344778 -PNCK 0.000479189687504524 -TREX2 0.126734816031738 -PNMA5 0.00609707539882633 -HAUS7 0.959453959935133 -MAGEA1 0.369816630513072 -SLC6A8 0.991889602732559 -BCAP31 0.869367470623907 -ATP2B3 0.998768934027877 -ZNF275 0.0566089965908238 -IDH3G 0.968084888689833 -MECP2 0.698089047724915 -ABCD1 0.982118837885542 -IRAK1 0.994301923500418 -PDZD4 0.930873831930578 -RENBP 0.962622292028919 -OPN1MW2 0.574117353273909 -HCFC1 0.999995934499134 -OPN1LW 0.907796474628102 -SRPK3 0.179643538378432 -SSR4 0.806792211750699 -ARHGAP4 0.983661940481215 -AVPR2 0.119885620397291 -TMEM187 0.218658492062468 -L1CAM 0.999983695509006 -OPN1MW 0.502014146694304 -NAA10 0.188427799697794 -PLXNB3 0.103343014352593 -EMD 0.84440846047199 -FLNA 0.999999987607637 -CTAG2 0.00595438745177886 -DNASE1L1 0.0612658007905369 -FAM3A 0.844646763701685 -G6PD 0.966391447459592 -RPL10 0.90119329809699 -UBL4A 0.275271317341126 -TKTL1 0.99702623090185 -GDI1 0.987884008546527 -TAZ 0.966526482271322 -IKBKG 0.628614516375526 -LAGE3 0.227379900839686 -FAM50A 0.945400813260401 -PLXNA3 0.983112793293949 -SLC10A3 0.629239798913129 -ATP6AP1 0.827633657438673 -CMC4 0.164577983805174 -RAB39B 0.715196297042307 -VBP1 0.822547586801538 -TMLHE 0.00276292005354084 -MPP1 0.940116717603012 -SPRY3 0.00584474683683058 -GAB3 0.990602402777157 -BRCC3 0.0339670741642349 -FUNDC2 0.841264939337729 -CLIC2 0.493262623526124 -DKC1 0.9989001727892 -F8 0.999999811590639 -MTCP1 0.342313098947147 -IL9R 1.92052299627482e-06 -VAMP7 0.00463196348400117 -PCDH11Y 0.0363686431008104 -TGIF2LY 0.0768707616723098 -SRY 0.416019592282844 -RPS4Y1 0.502396329607095 -ZFY 0.255459999135225 -USP9Y 0.140701437950318 -AMELY 0.00205505416408899 -UTY 0.632058104202083 -KDM5D 0.0151340441544138 -TMSB4Y 0.334409877031708 -DDX3Y 0.773099529750687 -NLGN4Y 0.645547566883988 -EIF1AY 0.424064592561161 -RPS4Y2 0.00298794938170108
--- a/dir_plugins/FATHMM.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,149 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - FATHMM - -=head1 SYNOPSIS - - mv FATHMM.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin FATHMM,"python /path/to/fathmm/fathmm.py" - -=head1 DESCRIPTION - - A VEP plugin that gets FATHMM scores and predictions for missense variants. - - You will need the fathmm.py script and its dependencies (Python, Python - MySQLdb). You should create a "config.ini" file in the same directory as the - fathmm.py script with the database connection options. More information about - how to set up FATHMM can be found on the FATHMM website at - https://github.com/HAShihab/fathmm. - - A typical installation could consist of: - - > wget https://raw.github.com/HAShihab/fathmm/master/cgi-bin/fathmm.py - > wget ftp://supfam2.cs.bris.ac.uk/FATHMM/database/fathmm.v2.1.SQL - > mysql -h[host] -P[port] -u[user] -p[pass] -e"CREATE DATABASE fathmm" - > mysql -h[host] -P[port] -u[user] -p[pass] -Dfathmm < fathmm.v2.1.SQL - > echo "[DATABASE]\nHOST = [host]\nPORT = [port]\nUSER = [user]\nPASSWD = [pass]\nDB = fathmm\n" > config.ini - -=cut - -package FATHMM; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # get command - my $command = $self->params->[0]; - - die 'ERROR: No FATHMM command specified. Specify path to FATHMM with e.g. --plugin FATHMM,"python /path/to/fathmm/fathmm.py"\n' unless defined($command); - - die 'ERROR: Your FATHMM command does not look correct; it should looks something like "python /path/to/fathmm/fathmm.py"\n' unless $command =~ /python.+fathmm\.py/; - - $self->{command} = $command; - - die 'ERROR: Temporary directory '.$self->{config}->{tmpdir}.' not found - specify an existing directory with --tmpdir [dir]\n' unless -d $self->{config}->{tmpdir}; - - return $self; -} - -sub version { - return 71; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - FATHMM => "FATHMM prediction (score)", - }; -} - -sub run { - my ($self, $tva) = @_; - - # only for missense variants - return {} unless grep {$_->SO_term eq 'missense_variant'} @{$tva->get_all_OverlapConsequences}; - - # configure command - my $command = $self->{command}; - $command =~ m/(\s.+)\/.+/; - my $command_dir = $1; - - # configure tmp dir and in/out files for FATHMM - my $tmp_dir = $self->{config}->{tmpdir}; - my $tmp_in_file = $tmp_dir."/fathmm_$$\.in"; - my $tmp_out_file = $tmp_dir."/fatmm_$$\.out"; - - # get required input data from TVA - my $protein = $tva->transcript->{_protein} || $tva->transcript->translation->stable_id; - my $aa_change = $tva->pep_allele_string; - my $aa_pos = $tva->transcript_variation->translation_start; - $aa_change =~ s/\//$aa_pos/; - - # check we have valid strings - return {} unless $protein && $aa_change =~ /^[A-Z]\d+[A-Z]$/; - - # write input file - open IN, ">$tmp_in_file" or die "ERROR: Could not write to file $tmp_in_file\n"; - print IN "$protein $aa_change\n"; - close IN; - - # run command - my $fathmm_err = `cd $command_dir; $command $tmp_in_file $tmp_out_file;`; - - # read output file - open OUT, $tmp_out_file or die "ERROR: Could not read from file $tmp_out_file\n"; - - my ($pred, $score); - while(<OUT>) { - next if /^\#/; - chomp; - my @data = split; - ($pred, $score) = ($data[4], $data[5]); - } - close OUT; - - # delete temporary files - unlink($tmp_in_file, $tmp_out_file); - - return $pred && $score ? { - FATHMM => "$pred($score)", - } : {}; -} - -1; -
--- a/dir_plugins/FATHMM_MKL.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,128 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - FATHMM_MKL - -=head1 SYNOPSIS - - mv FATHMM_MKL.pm ~/.vep/Plugins - ./vep -i input.vcf --plugin FATHMM_MKL,fathmm-MKL_Current.tab.gz - -=head1 DESCRIPTION - - A VEP plugin that retrieves FATHMM-MKL scores for variants from a tabix-indexed - FATHMM-MKL data file. - - See https://github.com/HAShihab/fathmm-MKL for details. - - NB: The currently available data file is for GRCh37 only. - -=cut - -package FATHMM_MKL; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - - return $self; -} - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - my $self = shift; - return { - FATHMM_MKL_C => 'FATHMM-MKL coding score', - FATHMM_MKL_NC => 'FATHMM-MKL non-coding score', - } -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - return {} unless $vf->{start} eq $vf->{end}; - - # get allele, reverse comp if needed - my $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - return {} unless $allele =~ /^[ACGT]$/; - - # adjust coords, file is BED-like (but not 0-indexed, go figure...) - my ($s, $e) = ($vf->{start}, $vf->{end} + 1); - - foreach my $data(@{$self->get_data($vf->{chr}, $s, $e)}) { - if($data->{start} == $s && $allele eq $data->{alt}) { - return $data->{result}; - } - } - - return {}; -} - -sub parse_data { - my ($self, $line) = @_; - - my ($c, $s, $e, $ref, $alt, $nc_score, $nc_groups, $c_score, $c_groups) = split /\t/, $line; - - return { - start => $s, - end => $e - 1, - alt => $alt, - result => { - FATHMM_MKL_C => $c_score, - FATHMM_MKL_NC => $nc_score, - } - }; -} - -sub get_start { - return $_[1]->{start}; -} - -sub get_end { - return $_[1]->{end}; -} - -1; -
--- a/dir_plugins/G2P.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,1353 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - G2P - -=head1 SYNOPSIS - - mv G2P.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin G2P,file=/path/to/G2P.csv.gz - -=head1 DESCRIPTION - - A VEP plugin that uses G2P allelic requirements to assess variants in genes - for potential phenotype involvement. - - The plugin has multiple configuration options, though minimally requires only - the CSV file of G2P data. - - Options are passed to the plugin as key=value pairs, (defaults in parentheses): - - file : path to G2P data file, as found at http://www.ebi.ac.uk/gene2phenotype/downloads - - af_monoallelic : maximum allele frequency for inclusion for monoallelic genes (0.0001) - - af_biallelic : maximum allele frequency for inclusion for biallelic genes (0.005) - all_confidence_levels : set value to 1 to include all confidence levels: confirmed, probable and possible. - Default levels are confirmed and probable. - af_keys : reference populations used for annotating variant alleles with observed - allele frequencies. Allele frequencies are stored in VEP cache files. - Default populations are: - ESP: AA, EA - 1000 Genomes: AFR, AMR, EAS, EUR, SAS - gnomAD exomes: gnomAD, gnomAD_AFR, gnomAD_AMR, gnomAD_ASJ, gnomAD_EAS, gnomAD_FIN, gnomAD_NFE, gnomAD_OTH, gnomAD_SAS - Separate multiple values with '&' - af_from_vcf : set value to 1 to include allele frequencies from VCF file. - Specifiy the list of reference populations to include with --af_from_vcf_keys - af_from_vcf_keys : reference populations used for annotating variant alleles with observed - allele frequencies. Allele frequencies are retrieved from VCF files. If - af_from_vcf is set to 1 but no populations specified with --af_from_vcf_keys - all available reference populations are included. - TOPmed: TOPMed - UK10K: ALSPAC, TWINSUK - gnomAD exomes: gnomADe:AFR, gnomADe:ALL, gnomADe:AMR, gnomADe:ASJ, gnomADe:EAS, gnomADe:FIN, gnomADe:NFE, gnomADe:OTH, gnomADe:SAS - gnomAD genomes: gnomADg:AFR, gnomADg:ALL, gnomADg:AMR, gnomADg:ASJ, gnomADg:EAS, gnomADg:FIN, gnomADg:NFE, gnomADg:OTH - Separate multiple values with '&' - default_af : default frequency of the input variant if no frequency data is - found (0). This determines whether such variants are included; - the value of 0 forces variants with no frequency data to be - included as this is considered equivalent to having a frequency - of 0. Set to 1 (or any value higher than af) to exclude them. - types : SO consequence types to include. Separate multiple values with '&' - (splice_donor_variant,splice_acceptor_variant,stop_gained, - frameshift_variant,stop_lost,initiator_codon_variant, - inframe_insertion,inframe_deletion,missense_variant, - coding_sequence_variant,start_lost,transcript_ablation, - transcript_amplification,protein_altering_variant) - - log_dir : write stats to log files in log_dir - - txt_report : write all G2P complete genes and attributes to txt file - - html_report : write all G2P complete genes and attributes to html file - - Example: - - --plugin G2P,file=G2P.csv,af_monoallelic=0.05,af_keys=AA&gnomAD_ASJ,types=stop_gained&frameshift_variant - --plugin G2P,file=G2P.csv,af_monoallelic=0.05,types=stop_gained&frameshift_variant - --plugin G2P,file=G2P.csv,af_monoallelic=0.05,af_from_vcf=1 - --plugin G2P,file=G2P.csv - -=cut - -package G2P; - -use strict; -use warnings; - -use Cwd; -use Scalar::Util qw(looks_like_number); -use FileHandle; -use Text::CSV; -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -my %DEFAULTS = ( - - # vars must have a frequency <= to this to pass - af => 0.001, - af_monoallelic => 0.0001, - af_biallelic => 0.005, - - af_keys => [qw(AA AFR AMR EA EAS EUR SAS gnomAD gnomAD_AFR gnomAD_AMR gnomAD_ASJ gnomAD_EAS gnomAD_FIN gnomAD_NFE gnomAD_OTH gnomAD_SAS)], - - af_from_vcf_keys => [qw(ALSPAC TOPMed TWINSUK gnomADe:AFR gnomADe:ALL gnomADe:AMR gnomADe:ASJ gnomADe:EAS gnomADe:FIN gnomADe:NFE gnomADe:OTH gnomADe:SAS gnomADg:AFR gnomADg:ALL gnomADg:AMR gnomADg:ASJ gnomADg:EAS gnomADg:FIN gnomADg:NFE gnomADg:OTH)], - - # if no MAF data is found, default to 0 - # this means absence of MAF data is considered equivalent to MAF=0 - # set to 1 to do the "opposite", i.e. exclude variants with no MAF data - default_af => 0, - - confidence_levels => [qw(confirmed probable)], - - # only include variants with these consequence types - # currently not ontology-resolved, exact term matches only - types => {map {$_ => 1} qw(splice_donor_variant splice_acceptor_variant stop_gained frameshift_variant stop_lost initiator_codon_variant inframe_insertion inframe_deletion missense_variant coding_sequence_variant start_lost transcript_ablation transcript_amplification protein_altering_variant)}, - -); - -my $af_key_2_population_name = { - minor_allele_freq => 'global allele frequency (AF) from 1000 Genomes Phase 3 data', - AFR => '1000GENOMES:phase_3:AFR', - AMR => '1000GENOMES:phase_3:AMR', - EAS => '1000GENOMES:phase_3:EAS', - EUR => '1000GENOMES:phase_3:EUR', - SAS => '1000GENOMES:phase_3:SAS', - AA => 'Exome Sequencing Project 6500:African_American', - EA => 'Exome Sequencing Project 6500:European_American', - gnomAD => 'Genome Aggregation Database:Total', - gnomAD_AFR => 'Genome Aggregation Database exomes:African/African American', - gnomAD_AMR => 'Genome Aggregation Database exomes:Latino', - gnomAD_ASJ => 'Genome Aggregation Database exomes:Ashkenazi Jewish', - gnomAD_EAS => 'Genome Aggregation Database exomes:East Asian', - gnomAD_FIN => 'Genome Aggregation Database exomes:Finnish', - gnomAD_NFE => 'Genome Aggregation Database exomes:Non-Finnish European', - gnomAD_OTH => 'Genome Aggregation Database exomes:Other (population not assigned)', - gnomAD_SAS => 'Genome Aggregation Database exomes:South Asian', - ALSPAC => 'UK10K:ALSPAC cohort', - TOPMed => 'Trans-Omics for Precision Medicine (TOPMed) Program', - TWINSUK => 'UK10K:TWINSUK cohort', - 'gnomADe:AFR' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:ALL' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:AMR' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:ASJ' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:EAS' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:FIN' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:NFE' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:OTH' => 'Genome Aggregation Database exomes v170228', - 'gnomADe:SAS' => 'Genome Aggregation Database exomes v170228', - 'gnomADg:AFR' => 'Genome Aggregation Database genomes v170228:African/African American', - 'gnomADg:ALL' => 'Genome Aggregation Database genomes v170228:All gnomAD genomes individuals', - 'gnomADg:AMR' => 'Genome Aggregation Database genomes v170228:Latino', - 'gnomADg:ASJ' => 'Genome Aggregation Database genomes v170228:Ashkenazi Jewish', - 'gnomADg:EAS' => 'Genome Aggregation Database genomes v170228:East Asian', - 'gnomADg:FIN' => 'Genome Aggregation Database genomes v170228:Finnish', - 'gnomADg:NFE' => 'Genome Aggregation Database genomes v170228:Non-Finnish European', - 'gnomADg:OTH' => 'Genome Aggregation Database genomes v170228:Other (population not assigned)', -}; - -my $allelic_requirements = { - 'biallelic' => { af => 0.005, rules => {HET => 2, HOM => 1} }, - 'monoallelic' => { af => 0.0001, rules => {HET => 1, HOM => 1} }, - 'hemizygous' => { af => 0.0001, rules => {HET => 1, HOM => 1} }, - 'x-linked dominant' => { af => 0.0001, rules => {HET => 1, HOM => 1} }, - 'x-linked over-dominance' => { af => 0.0001, rules => {HET => 1, HOM => 1} }, -}; - -my @allelic_requirement_terms = keys %$allelic_requirements; - -my @population_wide = qw(minor_allele_freq AA AFR ALSPAC AMR EA EAS EUR SAS TOPMed TWINSUK gnomAD gnomAD_AFR gnomAD_AMR gnomAD_ASJ gnomAD_EAS gnomAD_FIN gnomAD_NFE gnomAD_OTH gnomAD_SAS gnomADe:AFR gnomADe:ALL gnomADe:AMR gnomADe:ASJ gnomADe:EAS gnomADe:FIN gnomADe:NFE gnomADe:OTH gnomADe:SAS gnomADg:AFR gnomADg:ALL gnomADg:AMR gnomADg:ASJ gnomADg:EAS gnomADg:FIN gnomADg:NFE gnomADg:OTH); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $supported_af_keys = { map {$_ => 1} @population_wide }; - - my $params = $self->params_to_hash(); - my $file = ''; - - # user only supplied file as first param? - if (!keys %$params) { - $file = $self->params->[0]; - } - else { - $file = $params->{file}; - - # process types - if ($params->{types}) { - $params->{types} = {map {$_ => 1} split(/[\;\&\|]/, $params->{types})}; - } - - # check af - foreach my $af (qw/af_monoallelic af_biallelic/) { - if($params->{$af}) { - die("ERROR: Invalid value for af: ".$params->{$af} . "\n") unless - looks_like_number($params->{$af}) && ($params->{$af} >= 0 && $params->{$af} <= 1) - } - } - - my $assembly = $self->{config}->{assembly}; - my $af_from_vcf_key_2_collection_id = { - ALSPAC => {GRCh37 => 'uk10k_GRCh37', GRCh38 => 'uk10k_GRCh38'}, - TOPMed => {GRCh37 => 'topmed_GRCh37', GRCh38 => 'topmed_GRCh38'}, - TWINSUK => {GRCh37 => 'uk10k_GRCh37', GRCh38 => 'uk10k_GRCh38'}, - 'gnomADe:AFR' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:ALL' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:AMR' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:ASJ' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:EAS' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:FIN' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:NFE' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:OTH' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADe:SAS' => {GRCh37 => 'gnomADe_GRCh37', GRCh38 => 'gnomADe_GRCh38'}, - 'gnomADg:AFR' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:ALL' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:AMR' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:ASJ' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:EAS' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:FIN' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:NFE' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - 'gnomADg:OTH' => {GRCh37 => 'gnomADg_GRCh37', GRCh38 => 'gnomADg_GRCh38'}, - }; - - my @keys = (); - my $vcf_collection_ids = {}; - if ($params->{af_keys}) { - push @keys, $params->{af_keys}; - } else { - push @keys, @{$DEFAULTS{af_keys}}; - } - if ($params->{af_from_vcf}) { - if ($params->{af_from_vcf_keys}) { - push @keys, $params->{af_from_vcf_keys}; - } else { - push @keys, @{$DEFAULTS{af_from_vcf_keys}}; - } - } - - my @af_keys = (); - foreach my $af_key_set (@keys) { - foreach my $af_key (split(/[\;\&\|]/, $af_key_set)) { - die("ERROR: af_key: " . $af_key . " not supported. Check plugin documentation for supported af_keys.\n") unless $supported_af_keys->{$af_key}; - push @af_keys, $af_key; - if ($af_from_vcf_key_2_collection_id->{$af_key}) { - - $vcf_collection_ids->{$af_from_vcf_key_2_collection_id->{$af_key}->{$assembly}} = 1; - } - } - } - $params->{af_keys} = \@af_keys; - $params->{vcf_collection_ids} = $vcf_collection_ids; - } - - my ($sec, $min, $hour, $mday, $mon, $year, $wday, $yday, $isdst) = localtime(time); - $year += 1900; - $mon++; - my $stamp = join('_', ($year, $mon, $mday, $hour, $min)); - my $cwd_dir = getcwd; - my $new_log_dir = "$cwd_dir/g2p_log_dir\_$stamp"; - my $log_dir = $params->{log_dir} || $new_log_dir; - if (-d $log_dir) { - my @files = <$log_dir/*>; - if (scalar @files > 0) { - unlink glob "'$log_dir/*.*'"; - } - @files = <$log_dir/*>; - if (scalar @files > 0) { - mkdir $new_log_dir, 0755; - $params->{log_dir} = $new_log_dir; - } - } else { - mkdir $log_dir, 0755; - $params->{log_dir} = $log_dir; - } - - foreach my $report_type (qw/txt_report html_report/) { - if (!$params->{$report_type}) { - my $file_type = ($report_type eq 'txt_report') ? 'txt' : 'html'; - $params->{$report_type} = $cwd_dir . "/$report_type\_$stamp.$file_type"; - } - } - - if ($params->{all_confidence_levels}) { - push @{$params->{confidence_levels}}, 'possible', @{$DEFAULTS{confidence_levels}}; - } - - # copy in default params - $params->{$_} //= $DEFAULTS{$_} for keys %DEFAULTS; - $self->{user_params} = $params; - - if (!defined($self->{config}->{reg})) { - my $reg = 'Bio::EnsEMBL::Registry'; - $reg->load_registry_from_db( - -host => $self->config->{host}, - -user => $self->config->{user}, - -port => $self->config->{port}, - -db_version => $self->config->{db_version}, - -species => $self->config->{species}, - -no_cache => $self->config->{no_slice_cache}, - ); - $self->{config}->{reg} = $reg; - } - - my $va = $self->{config}->{reg}->get_adaptor($self->{config}->{species}, 'variation', 'variation'); - $va->db->use_vcf(1); - $va->db->include_failed_variations(1); - $self->{config}->{va} = $va; - my $pa = $self->{config}->{reg}->get_adaptor($self->{config}->{species}, 'variation', 'population'); - $self->{config}->{pa} = $pa; - my $vca = $self->{config}->{reg}->get_adaptor($self->{config}->{species}, 'variation', 'VCFCollection'); - $self->{config}->{vca} = $vca; - my $ta = $self->{config}->{reg}->get_adaptor($self->{config}->{species}, 'core', 'transcript'); - $self->{config}->{ta} = $ta; - - # read data from file - $self->{gene_data} = $self->read_gene_data_from_file($file); - $self->synonym_mappings(); - - # force some config params - $self->{config}->{individual} //= ['all']; - $self->{config}->{symbol} = 1; - - $self->{config}->{check_existing} = 1; - $self->{config}->{failed} = 1; - $self->{config}->{af} = 1; - $self->{config}->{af_1kg} = 1; - $self->{config}->{af_esp} = 1; - $self->{config}->{af_gnomad} = 1; -# $self->{config}->{sift} = 'b'; -# $self->{config}->{polyphen} = 'b'; -# $self->{config}->{hgvsc} = 1; -# $self->{config}->{hgvsp} = 1; - - # tell VEP we have a cache so stuff gets shared/merged between forks - $self->{has_cache} = 1; - $self->{cache}->{g2p_in_vcf} = {}; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - my $self = shift; - - return { - G2P_flag => 'Flags zygosity of valid variants for a G2P gene', - G2P_complete => 'Indicates this variant completes the allelic requirements for a G2P gene', - G2P_gene_req => 'MONO or BI depending on the context in which this gene has been explored', - }; -} - -sub run { - my ($self, $tva, $line) = @_; - - # only interested if we know the zygosity - my $zyg = $line->{Extra}->{ZYG} || $line->{ZYG}; - return {} unless $zyg; - - # only interested in given gene set - my $tr = $tva->transcript; - - my $ensembl_gene_id = $tr->{_gene}->stable_id; - my $gene_symbol = $tr->{_gene_symbol} || $tr->{_gene_hgnc}; - return {} unless $gene_symbol; - my $gene_data = $self->gene_data($gene_symbol); - if (! defined $gene_data) { - my $ensembl_gene_id = $tr->{_gene}->stable_id; - $gene_data = $self->gene_data($ensembl_gene_id); - } - - if (!$self->{cache}->{g2p_in_vcf}->{$gene_symbol}) { - $self->write_report('G2P_in_vcf', $gene_symbol); - $self->{cache}->{g2p_in_vcf}->{$gene_symbol} = 1; - } - return {} unless defined $gene_data; - - my @ars = ($gene_data->{'allelic requirement'}) ? @{$gene_data->{'allelic requirement'}} : (); - my %seen; - @ars = grep { !$seen{$_}++ } @ars; - - return {} unless (@ars && ( grep { exists($allelic_requirements->{$_}) } @ars)); - # limit by type - my @consequence_types = map { $_->SO_term } @{$tva->get_all_OverlapConsequences}; - - return {} unless grep {$self->{user_params}->{types}->{$_->SO_term}} @{$tva->get_all_OverlapConsequences}; - - # limit by MAF - my $threshold = 0; - my ($freqs, $existing_variant, $ar_passed) = @{$self->get_freq($tva, \@ars)}; - - return {} if (!keys %$ar_passed); - - my $vf = $tva->base_variation_feature; - my $allele = $tva->variation_feature_seq; - my $start = $vf->{start}; - my $end = $vf->{end}; - - my $individual = $vf->{individual}; - my $vf_name = $vf->variation_name; - if ($vf_name || $vf_name eq '.') { - $vf_name = ($vf->{original_chr} || $vf->{chr}) . '_' . $vf->{start} . '_' . ($vf->{allele_string} || $vf->{class_SO_term}); - } - my $allele_string = $vf->{allele_string}; - my @alleles = split('/', $allele_string); - my $ref = $alleles[0]; - my $seq_region_name = $vf->{chr}; - - my $params = $self->{user_params}; - my $refseq = $tr->{_refseq} || 'NA'; - my $tr_stable_id = $tr->stable_id; - my $hgvs_t = $tva->hgvs_transcript || 'NA'; - my $hgvs_p = $tva->hgvs_protein || 'NA'; - - my ($clin_sig, $novel, $failed, $frequencies, $existing_name) = ('NA', 'yes', 'NA', 'NA', 'NA'); - if ($existing_variant) { - $clin_sig = $existing_variant->{clin_sig} || 'NA'; - $failed = ($existing_variant->{failed}) ? 'yes' : 'no'; - $existing_name = $existing_variant->{variation_name} || 'NA'; - $novel = 'no'; - } - - my $pph_score = (defined $tva->polyphen_score) ? $tva->polyphen_score : 'NA'; - my $pph_pred = (defined $tva->polyphen_prediction) ? $tva->polyphen_prediction : 'NA'; - my $sift_score = (defined $tva->sift_score) ? $tva->sift_score : 'NA'; - my $sift_pred = (defined $tva->sift_prediction) ? $tva->sift_prediction : 'NA'; - - if (scalar keys %$freqs > 0) { - $frequencies = join(',', map {"$_=$freqs->{$_}"} keys %$freqs); - } - - my $ar = join(',', sort keys %$ar_passed); - my $ar_in_g2pdb = join(',', sort @ars); - my $g2p_data = { - 'zyg' => $zyg, - 'allele_requirement' => $ar, - 'ar_in_g2pdb' => $ar_in_g2pdb, - 'frequencies' => $frequencies, - 'consequence_types' => join(',', @consequence_types), - 'refseq' => $refseq, - 'failed' => $failed, - 'clin_sig' => $clin_sig, - 'novel' => $novel, - 'existing_name' => $existing_name, - 'hgvs_t' => $hgvs_t, - 'hgvs_p' => $hgvs_p, - 'vf_location' => "$seq_region_name:$start-$end $ref/$allele", - 'sift_score' => "$sift_score", - 'sift_prediction' => $sift_pred, - 'polyphen_score' => "$pph_score", - 'polyphen_prediction' => $pph_pred, - }; - - my %return = ( - G2P_flag => $zyg - ); - - - $self->write_report('G2P_flag', $gene_symbol, $tr_stable_id, $individual, $vf_name, $g2p_data); - - $self->write_report('G2P_complete', $gene_symbol, $tr_stable_id, $individual, $vf_name, $ar, $zyg); - - my $cache = $self->{cache}->{$individual}->{$tr->stable_id} ||= {}; - - delete $cache->{$vf_name} if exists($cache->{$vf_name}); - - # biallelic genes require >=1 hom or >=2 hets - - my $gene_reqs = {}; - - foreach my $ar (keys %$ar_passed) { - if($ar eq 'biallelic') { - # homozygous, report complete - if(uc($zyg) eq 'HOM') { - $return{G2P_complete} = 1; - $gene_reqs->{BI} = 1; - } - # heterozygous - # we need to cache that we've observed one - elsif(uc($zyg) eq 'HET') { - if(scalar keys %$cache) { - $return{G2P_complete} = 1; - } - $cache->{$vf_name} = 1; - } - } - # monoallelic genes require only one allele - elsif($ar eq 'monoallelic' || $ar eq 'x-linked dominant' || $ar eq 'hemizygous' || $ar eq 'x-linked over-dominance') { - $return{G2P_complete} = 1; - $gene_reqs->{MONO} = 1; - } - else { - return {}; - } - } - if ($return{G2P_complete}) { - $return{G2P_gene_req} = join(',', sort keys %$gene_reqs); - } - - return \%return; -} - -# read G2P CSV dump -# as from http://www.ebi.ac.uk/gene2phenotype/downloads -sub read_gene_data_from_file { - my $self = shift; - my $file = shift; - my $delimiter = shift; - my (@headers, %gene_data); - - my $assembly = $self->{config}->{assembly}; - die("ERROR: No file specified or could not read from file ".($file || '')."\n") unless $file && -e $file; - - my @confidence_levels = @{$self->{user_params}->{confidence_levels}}, "\n"; - - # determine file type - my $file_type; - my $fh = FileHandle->new($file, 'r'); - while (<$fh>) { - chomp; - if (/Model_Of_Inheritance/) { - $file_type = 'panelapp'; - } elsif (/"allelic requirement"/) { - $file_type = 'g2p'; - } else { - $file_type = 'unknown'; - } - last; - } - $fh->close(); - if ($file_type eq 'unknown') { - if ($file =~ /gz$/) { - die("ERROR: G2P plugin can only read uncompressed data"); - } else { - die("ERROR: Could not recognize input file format. Format must be one of panelapp, g2p or custom. Check website for details: https://www.ebi.ac.uk/gene2phenotype/g2p_vep_plugin"); - } - } - - if ($file_type eq 'panelapp') { - my @headers = (); - my $csv = Text::CSV->new ({ sep_char => "\t" }); - open my $fh, "<:encoding(utf8)", "$file" or die "$file: $!"; - while ( my $row = $csv->getline( $fh ) ) { - unless (@headers) { - @headers = @$row; - } else { - my %tmp = map {$headers[$_] => $row->[$_]} (0..$#headers); - my $gene_symbol = $tmp{"Gene Entity Symbol"}; - my $ensembl_gene_id = ""; - if ($assembly eq 'GRCh37') { - $ensembl_gene_id = $tmp{"EnsemblId(GRch37)"}; - } else { # GRCh38 - $ensembl_gene_id = $tmp{"EnsemblId(GRch38)"}; - } - if ($ensembl_gene_id) { - my @ars = (); - my $allelic_requirement_panel_app = $tmp{"Model_Of_Inheritance"}; - if ($allelic_requirement_panel_app =~ m/MONOALLELIC|BOTH/) { - push @ars, 'monoallelic'; - } elsif ($allelic_requirement_panel_app =~ m/BIALLELIC|BOTH/) { - push @ars, 'biallelic'; - } elsif ($allelic_requirement_panel_app eq 'X-LINKED: hemizygous mutation in males, biallelic mutations in females') { - push @ars, 'hemizygous'; - } elsif ($allelic_requirement_panel_all eq 'X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)') { - push @ars, 'x-linked dominant'; - } else { - $self->write_report('log', "no allelelic_requirement for $ensembl_gene_id"); - } - foreach my $ar (@ars) { - push @{$gene_data{$ensembl_gene_id}->{"allelic requirement"}}, $ar; - } - } else { - $self->write_report('log', "no ensembl gene id for $gene_symbol"); - } - } - } - $csv->eof or $csv->error_diag(); - close $fh; - } - - if ($file_type eq 'g2p') { - # this regexp allows for nested ",", e.g. - # item,description - # cheese,"salty,delicious" - my $re = qr/(?: "\( ( [^()""]* ) \)" | \( ( [^()]* ) \) | " ( [^"]* ) " | ( [^,]* ) ) , \s* /x; - - my $fh = FileHandle->new($file, 'r'); - - while(<$fh>) { - chomp; - $_ =~ s/\R//g; - my @split = grep defined, "$_," =~ /$re/g; - unless(@headers) { - if ($file_type eq 'g2p') { - @headers = map {s/\"//g; $_} @split; - } else { - @headers = @split; - } - } - else { - my %tmp = map {$headers[$_] => $split[$_]} (0..$#split); - die("ERROR: Gene symbol column not found\n$_\n") unless $tmp{"gene symbol"}; - my $confidence_value = $tmp{"DDD category"}; - next if (!grep{$_ eq $confidence_value} @confidence_levels); - my $gene_symbol = $tmp{"gene symbol"}; - $gene_data{$gene_symbol}->{"prev symbols"} = $tmp{"prev symbols"}; - push @{$gene_data{$gene_symbol}->{"allelic requirement"}}, $tmp{"allelic requirement"} if ($tmp{"allelic requirement"}); - $self->write_report('G2P_list', $tmp{"gene symbol"}, $tmp{"DDD category"}); - } - } - $fh->close; - } - return \%gene_data; -} - -# return either whole gene data hash or one gene's data -# this should allow updates to this plugin to e.g. query a REST server, for example -sub gene_data { - my ($self, $gene_symbol) = @_; - my $gene_data = $self->{gene_data}->{$gene_symbol}; - if (!$gene_data) { - my $prev_gene_symbol = $self->{prev_symbol_mappings}->{$gene_symbol}; - return $prev_gene_symbol ? $self->{gene_data}->{$prev_gene_symbol} : undef; - } - return $gene_data; -} - -sub synonym_mappings { - my $self = shift; - my $gene_data = $self->{gene_data}; - my $synonym_mappings = {}; - foreach my $gene_symbol (keys %$gene_data) { - my $prev_symbols = $gene_data->{$gene_symbol}->{'prev symbols'}; - if ($prev_symbols) { - foreach my $prev_symbol (split(';', $prev_symbols)) { - $synonym_mappings->{$prev_symbol} = $gene_symbol; - } - } - } - $self->{prev_symbol_mappings} = $synonym_mappings; -} - -sub get_freq { - my $self = shift; - my $tva = shift; - my $ars = shift; - my $allele = $tva->variation_feature_seq; - my $vf = $tva->base_variation_feature; - reverse_comp(\$allele) if $vf->{strand} < 0; - my $vf_name = $vf->variation_name; - if ($vf_name || $vf_name eq '.') { - $vf_name = ($vf->{original_chr} || $vf->{chr}) . '_' . $vf->{start} . '_' . ($vf->{allele_string} || $vf->{class_SO_term}); - } - my $cache = $self->{cache}->{$vf_name}->{_g2p_freqs} ||= {}; - - if (exists $cache->{$allele}->{failed}) { - return [$cache->{$allele}->{freq}, $cache->{$allele}->{ex_variant}, {}]; - } - - if (exists $cache->{$allele}->{freq}) { - return [$cache->{$allele}->{freq}, $cache->{$allele}->{ex_variant}, $cache->{$allele}->{passed_ar}]; - } - - if (!$vf->{existing}) { - my $failed_ars = {}; - my $freqs = {}; - my $passed = $self->frequencies_from_VCF($freqs, $vf, $allele, $ars, $failed_ars); - if (!$passed) { - $cache->{$allele}->{failed} = 1; - return [{}, {}, {}]; - } else { - $cache->{$allele}->{freq} = $freqs; - $cache->{$allele}->{ex_variant} = undef; - # if we get to here return all allelic requirements that passed threshold filtering - my $passed_ar = {}; - foreach my $ar (@$ars) { - if (!$failed_ars->{$ar}) { - $passed_ar->{$ar} = 1; - } - } - $cache->{$allele}->{passed_ar} = $passed_ar; - return [$cache->{$allele}->{freq}, $cache->{$allele}->{ex_variant}, $cache->{$allele}->{passed_ar}]; - } - } - - my @existing_variants = @{$vf->{existing}}; - # favour dbSNP variants - my @dbSNP_variants = grep {$_->{variation_name} =~ /^rs/} @existing_variants; - if (@dbSNP_variants) { - @existing_variants = @dbSNP_variants; - } - foreach my $ex (@existing_variants) { - my $existing_allele_string = $ex->{allele_string}; - my $variation_name = $ex->{variation_name}; - my $freqs = {}; - my $failed_ars = {}; - foreach my $af_key (@{$self->{user_params}->{af_keys}}) { - my $freq = $self->{user_params}->{default_af}; - if ($af_key eq 'minor_allele_freq') { - if (defined $ex->{minor_allele_freq}) { - if (($ex->{minor_allele} || '') eq $allele ) { - $freq = $ex->{minor_allele_freq}; - } else { - $freq = $self->correct_frequency($tva, $existing_allele_string, $ex->{minor_allele}, $ex->{minor_allele_freq}, $allele, $variation_name, $af_key, $vf_name) || $freq; - } - } - } - else { - my @pairs = split(',', $ex->{$af_key} || ''); - my $found = 0; - if (scalar @pairs == 0) { - $found = 1; # no allele frequency for this population/af_key available - } - foreach my $pair (@pairs) { - my ($a, $f) = split(':', $pair); - if(($a || '') eq $allele && defined($f)) { - $freq = $f; - $found = 1; - } - } - if (!$found) { - $freq = $self->correct_frequency($tva, $existing_allele_string, undef, undef, $allele, $variation_name, $af_key, $vf_name) || $freq; - } - } - if (!$self->continue_af_annotation($ars, $failed_ars, $freq)) { - # cache failed results - $cache->{$allele}->{failed} = 1; - return [$cache->{$allele}->{freq}, $cache->{$allele}->{ex_variant}, {}]; - } - $freqs->{$af_key} = $freq if ($freq); - } - if ($self->{user_params}->{af_from_vcf}) { - my $passed = $self->frequencies_from_VCF($freqs, $vf, $allele, $ars, $failed_ars); - if (!$passed) { - $cache->{$allele}->{failed} = 1; - return [$cache->{$allele}->{freq}, $cache->{$allele}->{ex_variant}, {}]; - } - } - $cache->{$allele}->{freq} = $freqs; - $cache->{$allele}->{ex_variant} = $ex; - - # if we get to here return all allelic requirements that passed threshold filtering - my $passed_ar = {}; - foreach my $ar (@$ars) { - if (!$failed_ars->{$ar}) { - $passed_ar->{$ar} = 1; - } - } - $cache->{$allele}->{passed_ar} = $passed_ar; - - } - - return [$cache->{$allele}->{freq}, $cache->{$allele}->{ex_variant}, $cache->{$allele}->{passed_ar}]; -} - -sub correct_frequency { - my ($self, $tva, $allele_string, $minor_allele, $af, $allele, $variation_name, $af_key, $vf_name) = @_; - - my @existing_alleles = split('/', $allele_string); - if (!grep( /^$allele$/, @existing_alleles)) { - return 0.0; - } - - if ($af_key eq 'minor_allele_freq' && (scalar @existing_alleles == 2)) { - my $existing_ref_allele = $existing_alleles[0]; - my $existing_alt_allele = $existing_alleles[1]; - if ( ($minor_allele eq $existing_ref_allele && ($allele eq $existing_alt_allele)) || - ($minor_allele eq $existing_alt_allele && ($allele eq $existing_ref_allele)) ) { - return (1.0 - $af); - } - } else { - my $va = $self->{config}->{va}; - my $pa = $self->{config}->{pa}; - my $variation = $va->fetch_by_name($variation_name); - my $af_key = $self->{user_params}->{af_keys}; - my $population_name = $af_key_2_population_name->{$af_key}; - if ($population_name) { - my $population = $self->{config}->{$population_name}; - if (!$population) { - $population = $pa->fetch_by_name($population_name); - $self->{config}->{$population_name} = $population; - } - foreach (@{$variation->get_all_Alleles($population)}) { - if ($_->allele eq $allele) { - return $_->frequency; - } - } - } - } - return 0.0; -} - -sub frequencies_from_VCF { - my $self = shift; - my $freqs = shift; - my $vf = shift; - my $vf_allele = shift; - my $ars = shift; - my $failed_ars = shift; - my $vca = $self->{config}->{vca}; - my $collections = $vca->fetch_all; - foreach my $vc (@$collections) { - next if (! $self->{user_params}->{vcf_collection_ids}->{$vc->id}); - my $alleles = $vc->get_all_Alleles_by_VariationFeature($vf); - foreach my $allele (@$alleles) { - if ($allele->allele eq $vf_allele) { - my $af_key = $allele->population->name; - my $freq = $allele->frequency; - return 0 if (!$self->continue_af_annotation($ars, $failed_ars, $freq)); - $freqs->{$af_key} = $freq; - } - } - } - return 1; -} - -sub continue_af_annotation { - my $self = shift; - my $ars = shift; - my $failed_ars = shift; - my $freq = shift; - foreach my $ar (@$ars) { - if (!$failed_ars->{$ar}) { - if (defined $allelic_requirements->{$ar}) { - my $threshold = $allelic_requirements->{$ar}->{af}; - if ($freq > $threshold) { - $failed_ars->{$ar} = 1; - } - } - } - } - return (scalar @$ars != scalar keys %$failed_ars); -} - - - -sub write_report { - my $self = shift; - my $flag = shift; - my $log_dir = $self->{user_params}->{log_dir}; - my $log_file = "$log_dir/$$.txt"; - open(my $fh, '>>', $log_file) or die "Could not open file '$flag $log_file' $!"; - if ($flag eq 'G2P_list') { - my ($gene_symbol, $DDD_category) = @_; - $DDD_category ||= 'Not assigned'; - print $fh "$flag\t$gene_symbol\t$DDD_category\n"; - } elsif ($flag eq 'G2P_in_vcf') { - my $gene_symbol = shift; - print $fh "$flag\t$gene_symbol\n"; - } elsif ($flag eq 'G2P_complete') { - print $fh join("\t", $flag, @_), "\n"; - } elsif ($flag eq 'log') { - print $fh join("\t", $flag, @_), "\n"; - } else { - my ($gene_symbol, $tr_stable_id, $individual, $vf_name, $data) = @_; - $data = join(';', map {"$_=$data->{$_}"} sort keys %$data); - print $fh join("\t", $flag, $gene_symbol, $tr_stable_id, $individual, $vf_name, $data), "\n"; - } - close $fh; -} - -sub finish { - my $self = shift; - $self->generate_report; -} - -sub generate_report { - my $self = shift; - my $result_summary = $self->parse_log_files; - my $chart_txt_data = $self->chart_and_txt_data($result_summary); - my $chart_data = $chart_txt_data->{chart_data}; - my $txt_data = $chart_txt_data->{txt_data}; - my $canonical_transcripts = $chart_txt_data->{canonical_transcripts}; - $self->write_txt_output($txt_data); - $self->write_charts($result_summary, $chart_data, $canonical_transcripts); -} - -sub write_txt_output { - my $self = shift; - my $txt_output_data = shift; - my $txt_output_file = $self->{user_params}->{txt_report}; - my $fh_txt = FileHandle->new($txt_output_file, 'w'); - foreach my $individual (sort keys %$txt_output_data) { - foreach my $gene_symbol (keys %{$txt_output_data->{$individual}}) { - foreach my $ar (keys %{$txt_output_data->{$individual}->{$gene_symbol}}) { - foreach my $tr_stable_id (keys %{$txt_output_data->{$individual}->{$gene_symbol}->{$ar}}) { - my $is_canonical = $txt_output_data->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{is_canonical}; - my $canonical_tag = ($is_canonical) ? 'is_canonical' : 'not_canonical'; - my $req = $txt_output_data->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{REQ}; - my $variants = join(';', @{$txt_output_data->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{variants}}); - print $fh_txt join("\t", $individual, $gene_symbol, $tr_stable_id, $canonical_tag, "OBS=$ar", "REQ=$req", $variants), "\n"; - } - } - } - } - $fh_txt->close(); -} - -sub write_charts { - my $self = shift; - my $result_summary = shift; - my $chart_data = shift; - my $canonical_transcripts = shift; - - my $count_g2p_genes = keys %{$result_summary->{g2p_list}}; - my $count_in_vcf_file = keys %{$result_summary->{in_vcf_file}}; - my $count_complete_genes = scalar keys %{$result_summary->{complete_genes}}; - - my @charts = (); - my @frequencies_header = (); - - foreach my $short_name (sort @{$self->{user_params}->{af_keys}}) { - my $text = $af_key_2_population_name->{$short_name}; - push @frequencies_header, "<a style=\"cursor: pointer\" data-placement=\"top\" data-toggle=\"tooltip\" data-container=\"body\" title=\"$text\">$short_name</a>"; - } - - my $count = 1; - my @new_header = ( - 'Variant location and alleles (REF/ALT)', - 'Variant name', - 'Existing name', - 'Zygosity', - 'All allelic requirements from G2P DB', - 'Consequence types', - 'ClinVar annotation', - 'SIFT', - 'PolyPhen', - 'Novel variant', - 'Has been failed by Ensembl', - @frequencies_header, - 'HGVS transcript', - 'HGVS protein', - 'RefSeq IDs', - ); - - my $html_output_file = $self->{user_params}->{html_report}; - my $fh_out = FileHandle->new($html_output_file, 'w'); - print $fh_out stats_html_head(\@charts); - print $fh_out "<div class='main_content container'>"; - - - print $fh_out "<h1>G2P report</h1>"; - print $fh_out "<p>Input and output files:</p>"; - - print $fh_out "<dl class='dl-horizontal'>"; - print $fh_out "<dt>G2P list</dt>"; - print $fh_out "<dd>" . $self->{user_params}->{file} . "</dd>"; - print $fh_out "<dt>Log directory</dt>"; - print $fh_out "<dd>" . $self->{user_params}->{log_dir} . "</dd>"; - print $fh_out "<dt>HTML report</dt>"; - print $fh_out "<dd>" . $self->{user_params}->{html_report} . "</dd>"; - print $fh_out "<dt>TXT report</dt>"; - print $fh_out "<dd>" . $self->{user_params}->{txt_report} . "</dd>"; - print $fh_out "</dl>"; - - print $fh_out "<p>Counts:</p>"; - print $fh_out "<dl class='dl-horizontal text-overflow'>"; - print $fh_out "<dt>$count_g2p_genes</dt>"; - print $fh_out "<dd>G2P genes</dd>"; - print $fh_out "<dt>$count_in_vcf_file</dt>"; - print $fh_out "<dd>G2P genes in input VCF file</dd>"; - print $fh_out "<dt>$count_complete_genes</dt>"; - print $fh_out "<dd>G2P complete genes in input VCF file</dd>"; - print $fh_out "</dl>"; - - - print $fh_out "<h1>Summary of G2P complete genes per individual</h1>"; - print $fh_out "<p>G2P complete gene: A sufficient number of variant hits for the observed allelic requirement in at least one of the gene's transcripts. Variants are filtered by frequency.</p>"; - print $fh_out "<p>Frequency thresholds and number of required variant hits for each allelic requirement:</p>"; - - print $fh_out "<table class='table table-bordered'>"; - print $fh_out "<thead>"; - print $fh_out "<tr><th>Allelic requirement</th><th>Frequency threshold for filtering</th><th>Variant counts by zygosity</th></tr>"; - print $fh_out "</thead>"; - print $fh_out "<tbody>"; - foreach my $ar (sort keys %$allelic_requirements) { - my $af = $allelic_requirements->{$ar}->{af}; - my $rules = $allelic_requirements->{$ar}->{rules}; - my $rule = join(' OR ', map {"$_ >= $rules->{$_}"} keys %$rules); - print $fh_out "<tr><td>$ar</td><td>$af</td><td>$rule</td></tr>"; - } - print $fh_out "</tbody>"; - print $fh_out "</table>"; - -my $switch =<<SHTML; -<form> -<div class="checkbox"> - <label> - <input class="target" type="checkbox"> Show only canonical transcript - </label> -</div> -</form> -SHTML - - print $fh_out $switch; - - foreach my $individual (sort keys %$chart_data) { - foreach my $gene_symbol (keys %{$chart_data->{$individual}}) { - foreach my $ar (keys %{$chart_data->{$individual}->{$gene_symbol}}) { - print $fh_out "<ul>\n"; - foreach my $transcript_stable_id (keys %{$chart_data->{$individual}->{$gene_symbol}->{$ar}}) { - my $class = ($canonical_transcripts->{$transcript_stable_id}) ? 'is_canonical' : 'not_canonical'; - print $fh_out "<li><a class=\"$class\" href=\"#$individual\_$gene_symbol\_$ar\_$transcript_stable_id\">" . "$individual > $gene_symbol > $ar > $transcript_stable_id" . "</a> </li>\n"; - } - print $fh_out "</ul>\n"; - } - } - } - - foreach my $individual (sort keys %$chart_data) { - foreach my $gene_symbol (keys %{$chart_data->{$individual}}) { - foreach my $ar (keys %{$chart_data->{$individual}->{$gene_symbol}}) { - foreach my $transcript_stable_id (keys %{$chart_data->{$individual}->{$gene_symbol}->{$ar}}) { - my $class = ($canonical_transcripts->{$transcript_stable_id}) ? 'is_canonical' : 'not_canonical'; - print $fh_out "<div class=\"$class\">"; - my $name = "$individual\_$gene_symbol\_$ar\_$transcript_stable_id"; - my $title = "$individual > $gene_symbol > $ar > $transcript_stable_id"; - print $fh_out "<h3><a name=\"$name\"></a>$title <a title=\"Back to Top\" data-toggle=\"tooltip\" href='#top'><span class=\"glyphicon glyphicon-arrow-up\" aria-hidden=\"true\"></span></a></h3>\n"; - print $fh_out "<div class=\"table-responsive\" style=\"width:100%\">\n"; - print $fh_out "<TABLE class=\"table table-bordered table-condensed\" style=\"margin-left: 2em\">"; - print $fh_out "<thead>\n"; - print $fh_out "<tr>" . join('', map {"<th>$_</th>"} @new_header) . "</tr>\n"; - print $fh_out "</thead>\n"; - print $fh_out "<tbody>\n"; - foreach my $vf_data (@{$chart_data->{$individual}->{$gene_symbol}->{$ar}->{$transcript_stable_id}}) { - my $data_row = $vf_data->[0]; - my @tds = (); - foreach my $cell (@$data_row) { - my $value = $cell->[0]; - my $class = $cell->[1]; - if ($class) { - push @tds, "<td class=\"$class\">$value</td>"; - } else { - push @tds, "<td>$value</td>"; - } - } - print $fh_out "<tr>", join('', @tds), "</tr>\n"; - } - print $fh_out "</tbody>\n"; - print $fh_out "</TABLE>\n"; - print $fh_out "</div>\n"; - print $fh_out "</div>\n"; - } - } - } - } - print $fh_out stats_html_tail(); -} - -sub chart_and_txt_data { - my $self = shift; - my $result_summary = shift; - my $individuals = $result_summary->{individuals}; - my $complete_genes = $result_summary->{complete_genes}; - my $acting_ars = $result_summary->{acting_ars}; - my $new_order = $result_summary->{new_order}; - -# my @frequencies_header = sort keys $af_key_2_population_name; - my @frequencies_header = sort @{$self->{user_params}->{af_keys}}; - - my $assembly = $self->{config}->{assembly}; - my $transcripts = {}; - my $canonical_transcripts = {}; - my $transcript_adaptor = $self->{config}->{ta}; - my $chart_data = {}; - my $txt_output_data = {}; - - my $prediction2bgcolor = { - 'probably damaging' => 'danger', - 'deleterious' => 'danger', - 'possibly damaging' => 'warning', - 'unknown' => 'warning', - 'benign' => 'success', - 'tolerated' => 'success', - }; - - foreach my $individual (sort keys %$new_order) { - foreach my $gene_symbol (keys %{$new_order->{$individual}}) { - foreach my $ar (keys %{$new_order->{$individual}->{$gene_symbol}}) { - foreach my $transcript_stable_id (keys %{$new_order->{$individual}->{$gene_symbol}->{$ar}}) { - foreach my $vf_name (keys %{$new_order->{$individual}->{$gene_symbol}->{$ar}->{$transcript_stable_id}}) { - my $data = $individuals->{$individual}->{$gene_symbol}->{$vf_name}->{$transcript_stable_id}; - - my $hash = {}; - foreach my $pair (split/;/, $data) { - my ($key, $value) = split('=', $pair, 2); - $value ||= ''; - $hash->{$key} = $value; - } - my $vf_location = $hash->{vf_location}; - my $existing_name = $hash->{existing_name}; - if ($existing_name ne 'NA') { - $existing_name = "<a href=\"http://$assembly.ensembl.org/Homo_sapiens/Variation/Explore?v=$existing_name\">$existing_name</a>"; - } - my $refseq = $hash->{refseq}; - my $failed = $hash->{failed}; - my $clin_sign = $hash->{clin_sig}; - my $novel = $hash->{novel}; - my $hgvs_t = $hash->{hgvs_t}; - my $hgvs_p = $hash->{hgvs_p}; - my $allelic_requirement = $hash->{allele_requirement}; - my $observed_allelic_requirement = $hash->{ar_in_g2pdb}; - my $consequence_types = $hash->{consequence_types}; - my $zygosity = $hash->{zyg}; - my $sift_score = $hash->{sift_score} || '0.0'; - my $sift_prediction = $hash->{sift_prediction}; - my $sift = 'NA'; - my $sift_class = ''; - if ($sift_prediction ne 'NA') { - $sift = "$sift_prediction(" . "$sift_score)"; - $sift_class = $prediction2bgcolor->{$sift_prediction}; - } - my $polyphen_score = $hash->{polyphen_score} || '0.0'; - my $polyphen_prediction = $hash->{polyphen_prediction}; - my $polyphen = 'NA'; - my $polyphen_class = ''; - if ($polyphen_prediction ne 'NA') { - $polyphen = "$polyphen_prediction($polyphen_score)"; - $polyphen_class = $prediction2bgcolor->{$polyphen_prediction}; - } - - my %frequencies_hash = (); - if ($hash->{frequencies} ne 'NA') { - %frequencies_hash = split /[,=]/, $hash->{frequencies}; - } - my @frequencies = (); - my @txt_output_frequencies = (); - foreach my $population (@frequencies_header) { - my $frequency = $frequencies_hash{$population} || ''; - push @frequencies, ["$frequency"]; - if ($frequency) { - push @txt_output_frequencies, "$population=$frequency"; - } - } - my $is_canonical = 0; - if ($hash->{is_canonical}) { - $is_canonical = ($hash->{is_canonical} eq 'yes') ? 1 : 0; - } else { - if ($transcripts->{$transcript_stable_id}) { - $is_canonical = 1 if ($canonical_transcripts->{$transcript_stable_id}); - } else { - my $transcript = $transcript_adaptor->fetch_by_stable_id($transcript_stable_id); - if ($transcript) { - $is_canonical = $transcript->is_canonical(); - $transcripts->{$transcript_stable_id} = 1; - $canonical_transcripts->{$transcript_stable_id} = 1 if ($is_canonical); - } - } - } - my ($location, $alleles) = split(' ', $vf_location); - $location =~ s/\-/:/; - $alleles =~ s/\//:/; - - push @{$chart_data->{$individual}->{$gene_symbol}->{$ar}->{$transcript_stable_id}}, [[ - [$vf_location], - [$vf_name], - [$existing_name], - [$zygosity], - [$observed_allelic_requirement], - [$consequence_types], - [$clin_sign], - [$sift, $sift_class], - [$polyphen, $polyphen_class], - [$novel], - [$failed], - @frequencies, - [$hgvs_t], - [$hgvs_p], - [$refseq] - ], $is_canonical]; - - my $txt_output_variant = "$location:$alleles:$zygosity:$consequence_types:SIFT=$sift:PolyPhen=$polyphen"; - if (@txt_output_frequencies) { - $txt_output_variant .= ':' . join(',', @txt_output_frequencies); - } - $txt_output_data->{$individual}->{$gene_symbol}->{$ar}->{$transcript_stable_id}->{is_canonical} = $is_canonical; - $txt_output_data->{$individual}->{$gene_symbol}->{$ar}->{$transcript_stable_id}->{REQ} = $observed_allelic_requirement; - push @{$txt_output_data->{$individual}->{$gene_symbol}->{$ar}->{$transcript_stable_id}->{variants}}, $txt_output_variant; - } - } - } - } - } - return {txt_data => $txt_output_data, chart_data => $chart_data, canonical_transcripts => $canonical_transcripts}; -} - -sub parse_log_files { - my $self = shift; - - my $log_dir = $self->{user_params}->{log_dir}; - my @files = <$log_dir/*>; - - my $genes = {}; - my $individuals = {}; - my $complete_genes = {}; - my $g2p_list = {}; - my $in_vcf_file = {}; - my $cache = {}; - my $acting_ars = {}; - - my $new_order = {}; - - foreach my $file (@files) { - my $fh = FileHandle->new($file, 'r'); - while (<$fh>) { - chomp; - if (/^G2P_list/) { - my ($flag, $gene_symbol, $DDD_category) = split/\t/; - $g2p_list->{$gene_symbol} = 1; - } elsif (/^G2P_in_vcf/) { - my ($flag, $gene_symbol) = split/\t/; - $in_vcf_file->{$gene_symbol} = 1; - } elsif (/^G2P_complete/) { - my ($flag, $gene_symbol, $tr_stable_id, $individual, $vf_name, $ars, $zyg) = split/\t/; - foreach my $ar (split(',', $ars)) { - if ($ar eq 'biallelic') { - # homozygous, report complete - if (uc($zyg) eq 'HOM') { - $complete_genes->{$gene_symbol}->{$individual}->{$tr_stable_id} = 1; - $acting_ars->{$gene_symbol}->{$individual}->{$ar} = 1; - $new_order->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{$vf_name} = 1; - } - # heterozygous - # we need to cache that we've observed one - elsif (uc($zyg) eq 'HET') { - if (scalar keys %{$cache->{$individual}->{$tr_stable_id}} >= 1) { - $complete_genes->{$gene_symbol}->{$individual}->{$tr_stable_id} = 1; - $acting_ars->{$gene_symbol}->{$individual}->{$ar} = 1; - $new_order->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{$vf_name} = 1; - # add first observed het variant to the list - foreach my $vf (keys %{$cache->{$individual}->{$tr_stable_id}}) { - $new_order->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{$vf} = 1; - } - } - $cache->{$individual}->{$tr_stable_id}->{$vf_name}++; - } - } - # monoallelic genes require only one allele - elsif ($ar eq 'monoallelic' || $ar eq 'x-linked dominant' || $ar eq 'hemizygous' || $ar eq 'x-linked over-dominance') { - $complete_genes->{$gene_symbol}->{$individual}->{$tr_stable_id} = 1; - $acting_ars->{$gene_symbol}->{$individual}->{$ar} = 1; - $new_order->{$individual}->{$gene_symbol}->{$ar}->{$tr_stable_id}->{$vf_name} = 1; - } - } - } elsif (/^G2P_flag/) { - my ($flag, $gene_symbol, $tr_stable_id, $individual, $vf_name, $g2p_data) = split/\t/; - $genes->{$gene_symbol}->{"$individual\t$vf_name"}->{$tr_stable_id} = $g2p_data; - $individuals->{$individual}->{$gene_symbol}->{$vf_name}->{$tr_stable_id} = $g2p_data; - } else { - - } - } - $fh->close(); - } - return { - genes => $genes, - individuals => $individuals, - complete_genes => $complete_genes, - g2p_list => $g2p_list, - in_vcf_file => $in_vcf_file, - acting_ars => $acting_ars, - new_order => $new_order, - }; -} - - -sub stats_html_head { - my $charts = shift; - - my $html =<<SHTML; -<html> -<head> - <title>VEP summary</title> - <link rel="stylesheet" href="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/css/bootstrap.min.css" integrity="sha384-BVYiiSIFeK1dGmJRAkycuHAHRg32OmUcww7on3RYdg4Va+PmSTsz/K68vbdEjh4u" crossorigin="anonymous"> - <style> - a.inactive { - color: grey; - pointer-events:none; - } - </style> -</head> -<body> -SHTML - return $html; -} - -sub stats_html_tail { - my $script =<<SHTML; - <script src="https://ajax.googleapis.com/ajax/libs/jquery/1.12.4/jquery.min.js"></script> - <script src="https://maxcdn.bootstrapcdn.com/bootstrap/3.3.7/js/bootstrap.min.js"></script> - <script type="text/javascript" src="http://www.google.com/jsapi"></script> - <script> - \$( "input[type=checkbox]" ).on( "click", function(){ - if (\$('.target').is(':checked')) { - \$( "div.not_canonical" ).hide(); - \$("a.not_canonical").addClass("inactive"); - } else { - \$( "div.not_canonical" ).show(); - \$("a.not_canonical").removeClass("inactive"); - } - } ); - \$(document).ready(function(){ - \$('[data-toggle="tooltip"]').tooltip(); - }); - </script> -SHTML - return "\n</div>\n$script\n</body>\n</html>\n"; -} - -sub sort_keys { - my $data = shift; - my $sort = shift; - print $data, "\n"; - my @keys; - - # sort data - if(defined($sort)) { - if($sort eq 'chr') { - @keys = sort {($a !~ /^\d+$/ || $b !~ /^\d+/) ? $a cmp $b : $a <=> $b} keys %{$data}; - } - elsif($sort eq 'value') { - @keys = sort {$data->{$a} <=> $data->{$b}} keys %{$data}; - } - elsif(ref($sort) eq 'HASH') { - @keys = sort {$sort->{$a} <=> $sort->{$b}} keys %{$data}; - } - } - else { - @keys = keys %{$data}; - } - - return \@keys; -} - -1;
--- a/dir_plugins/GO.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,102 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - GO - -=head1 SYNOPSIS - - mv GO.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin GO - -=head1 DESCRIPTION - - A VEP plugin that retrieves Gene Ontology terms associated with - transcripts/translations via the Ensembl API. Requires database connection. - -=cut - -package GO; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # connect to DB for offline users - my $config = $self->{config}; - my $reg = $config->{reg}; - - if(!defined($self->{config}->{sa})) { - $reg = 'Bio::EnsEMBL::Registry'; - $reg->load_registry_from_db( - -host => $config->{host}, - -user => $config->{user}, - -pass => $config->{password}, - -port => $config->{port}, - -db_version => $config->{db_version}, - -species => $config->{species} =~ /^[a-z]+\_[a-z]+/i ? $config->{species} : undef, - -verbose => $config->{verbose}, - -no_cache => $config->{no_slice_cache}, - ); - } - - return $self; -} - -sub version { - return 73; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { 'GO' => 'GO terms associated with protein product'}; -} - -sub run { - my ($self, $tva) = @_; - - my $tr = $tva->transcript->translation; - return {} unless defined($tr); - - my $entries = $tr->get_all_DBEntries('GO'); - - my $string = join(",", map {$_->display_id.':'.$_->description} @$entries); - $string =~ s/\s+/\_/g; - - return { GO => $string }; -} - -1; -
--- a/dir_plugins/GXA.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,165 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - GXA - -=head1 SYNOPSIS - - mv GXA.pm ~/.vep/Plugins - ./vep -i variations.vcf --cache --plugin GXA - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - reports data from the Gene Expression Atlas. - - NB: no account is taken for comparing values across experiments; if values - exist for the same tissue in more than one experiment, the highest value - is reported. - -=cut - -package GXA; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - die("ERROR: This plugin is currently non-functional due to changes in the Gene Expression Atlas API"); - - $self->{species} = $self->{config}->{species}; - $self->{species} =~ s/\_/\%20/; - - $self->{url} = 'https://www.ebi.ac.uk/gxa/widgets/heatmap/multiExperiment.tsv?propertyType=bioentity_identifier'; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['BaseVariationFeature']; -} - -sub get_header_info { - my $self = shift; - - if(!exists($self->{_header_info})) { - - # get tissues using BRCA2 - my $url = sprintf( - '%s&species=%s&geneQuery=%s', - $self->{url}, - $self->{species}, - 'BRCA2' - ); - - open IN, "curl -s \"$url\" |"; - my @lines = <IN>; - - my %headers = (); - - while(my $line = shift @lines) { - next if $line =~ /^#/; - chomp $line; - $line =~ s/ /\_/g; - %headers = map {'GXA_'.$_ => "Tissue expression level in $_ from Gene Expression Atlas"} (split /\t/, $line); - last; - } - - close IN; - - $self->{_header_info} = \%headers; - }; - - return $self->{_header_info}; -} - -sub run { - my ($self, $tva) = @_; - - my $tr = $tva->transcript; - my $gene_id = $tr->{_gene_stable_id} || $tr->{_gene}->stable_id; - return {} unless $gene_id; - - if(!exists($self->{_cache}) || !exists($self->{_cache}->{$gene_id})) { - - my $url = sprintf( - '%s&species=%s&geneQuery=%s', - $self->{url}, - $self->{species}, - $gene_id - ); - - open IN, "curl -s \"$url\" |"; - - my $first = 1; - my (@headers, %data); - - while(<IN>) { - next if /^#/; - chomp; - - if($first) { - s/ /\_/g; - @headers = split /\t/, $_; - $first = 0; - } - else { - my @tmp = split /\t/, $_; - - for(my $i=0; $i<=$#headers; $i++) { - my ($h, $d) = ('GXA_'.$headers[$i], $tmp[$i]); - next unless defined($d) && $d =~ /^[0-9\.]+$/; - - if(exists($data{$h})) { - $data{$h} = $d if $d > $data{$h}; - } - else { - $data{$h} = $d; - } - } - } - } - - close IN; - - $self->{_cache}->{$gene_id} = \%data; - } - - return $self->{_cache}->{$gene_id}; -} - -1;
--- a/dir_plugins/GeneSplicer.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,369 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - GeneSplicer - -=head1 SYNOPSIS - - mv GeneSplicer.pm ~/.vep/Plugins - ./vep -i variants.vcf --plugin GeneSplicer,[path_to_genesplicer_bin],[path_to_training_dir],[option1=value],[option2=value] - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - runs GeneSplicer (https://ccb.jhu.edu/software/genesplicer/) to get - splice site predictions. - - It evaluates a tract of sequence either side of and including the - variant, both in reference and alternate states. The amount of - sequence included either side defaults to 100bp, but can be modified - by passing e.g. "context=50" as a parameter to the plugin. - - Any predicted splicing regions that overlap the variant are reported - in the output with one of four states: no_change, diff, gain, loss - - There follows a "/"-separated string consisting of the following data: - - 1) type (donor, acceptor) - 2) coordinates (start-end) - 3) confidence (Low, Medium, High) - 4) score - - Example: loss/acceptor/727006-727007/High/16.231924 - - If multiple sites are predicted, their reports are separated by ",". - - For diff, the confidence and score for both the reference and alternate - sequences is reported as REF-ALT. - - Example: diff/donor/621915-621914/Medium-Medium/7.020731-6.988368 - - Several parameters can be modified by passing them to the plugin string: - - context : change the amount of sequence added either side of - the variant (default: 100bp) - tmpdir : change the temporary directory used (default: /tmp) - cache_size : change how many sequences' scores are cached in memory - (default: 50) - - Example: --plugin GeneSplicer,$GS/bin/linux/genesplicer,$GS/human,context=200,tmpdir=/mytmp - - On some systems the binaries provided will not execute, but can be compiled from source: - - cd $GS/sources - make - cd - - ./vep [options] --plugin GeneSplicer,$GS/sources/genesplicer,$GS/human - - On Mac OSX the make step is known to fail; the genesplicer.cpp file requires modification: - - cd $GS/sources - perl -pi -e "s/^main /int main /" genesplicer.cpp - make - - -=cut - -package GeneSplicer; - -use strict; -use warnings; - -use Digest::MD5 qw(md5_hex); - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); -use Bio::EnsEMBL::Variation::Utils::VariationEffect qw(overlap); - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -our %DEFAULTS = ( - context => 100, - tmpdir => '/tmp', - cache_size => 50, -); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # we need sequence, so no offline mode unless we have FASTA - die("ERROR: cannot function in offline mode without a FASTA file\n") if $self->{config}->{offline} && !$self->{config}->{fasta}; - - my $params = $self->params; - - my $bin = shift @$params; - die("ERROR: genesplicer binary not specified\n") unless $bin; - die("ERROR: genesplicer binary not found\n") unless -e $bin; - my $test = `$bin 2>&1`; - die("ERROR: failed to run genesplicer binary:\n$test\n") unless $test =~ /^USAGE/; - $self->{_bin} = $bin; - - my $training_dir = shift @$params; - die("ERROR: training directory not specified\n") unless $training_dir; - die("ERROR: training directory not found\n") unless -d $training_dir; - $self->{_training_dir} = $training_dir; - - # defaults - $self->{'_param_'.$_} = $DEFAULTS{$_} for keys %DEFAULTS; - - # REST API passes 1 as first param - shift @$params if $params->[0] && $params->[0] eq '1'; - - # set/override with user params - foreach my $param(@$params) { - my ($key, $val) = split('=', $param); - die("ERROR: Failed to parse parameter $param\n") unless defined($key) && defined($val); - - $self->{'_param_'.$key} = $val; - } - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - GeneSplicer => "GeneSplicer predictions" - }; -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - # get up and downstream sequences - my $up_seq = $vf->{slice}->sub_Slice( - $vf->{start} - $self->{'_param_context'}, - $vf->{start} - 1, - $vf->strand - )->seq; - - my $down_seq = $vf->{slice}->sub_Slice( - $vf->{end} + 1, - $vf->{end} + $self->{'_param_context'}, - $vf->strand - )->seq; - - # create ref seq by grabbing reference TVA - my $ref_seq = join("", - $up_seq, - $tva->transcript_variation->get_reference_TranscriptVariationAllele->variation_feature_seq, - $down_seq - ); - - return {} unless $ref_seq =~ /^[ACGT]+$/; - - # create alt seq - my $alt_allele = $tva->variation_feature_seq; - $alt_allele =~ s/\-//g; - my $alt_seq = $up_seq.$alt_allele.$down_seq; - - - return {} unless $alt_seq =~ /^[ACGT]+$/; - - # reverse comp if strands differ - if($tva->transcript->strand != $vf->strand) { - reverse_comp(\$ref_seq); - reverse_comp(\$alt_seq); - } - - # get results - my $ref_results = $self->results_from_cache($ref_seq) || $self->results_from_seq($ref_seq); - my $alt_results = $self->results_from_cache($alt_seq) || $self->results_from_seq($alt_seq); - - # compare results both ways - my $diff_ref_to_alt = $self->compare_results($ref_results, $alt_results); - my $diff_alt_to_ref = $self->compare_results($alt_results, $ref_results); - - # get VF pos relative to tested sequence - my ($vf_start, $vf_end) = ($self->{'_param_context'} + 1, $self->{'_param_context'} + (($vf->{end} - $vf->{start}) + 1)); - - # get overlapping losses and gains - # and map to chromosome coords - my @losses = - map {$_->{gl} = 'loss'; $_} - @{$diff_ref_to_alt->{lost}}; - - my @gains = - map {$_->{gl} = 'gain'; $_} - @{$diff_alt_to_ref->{lost}}; - - my @diffs = - map {$_->{gl} = 'diff'; $_} - @{$diff_ref_to_alt->{diff}}; - - my $return = join(',', - map { - join('/', - $_->[0]->{gl}, - $_->[0]->{type}, - $_->[1]->{end5}.'-'.$_->[1]->{end3}, - $_->[0]->{confidence}, - $_->[0]->{score} - ) - } - map {[$_, $self->map_ss_coords($_, $vf)]} - grep {overlap($vf_start, $vf_end, $_->{end5}, $_->{end3})} - (@losses, @gains, @diffs) - ); - - # probably of interest to report splice sites were found - # but no difference between ref and alt - if(!$return && grep {overlap($vf_start, $vf_end, $_->{end5}, $_->{end3})} @$ref_results) { - $return = join(',', - map { - join('/', - 'no_change', - $_->[0]->{type}, - $_->[1]->{end5}.'-'.$_->[1]->{end3}, - $_->[0]->{confidence}, - $_->[0]->{score} - ) - } - map {[$_, $self->map_ss_coords($_, $vf)]} - grep {overlap($vf_start, $vf_end, $_->{end5}, $_->{end3})} @$ref_results - ); - } - - return $return ? { GeneSplicer => $return } : {}; -} - -sub results_from_seq { - my $self = shift; - my $seq = shift; - - # write seqs to file - my $seq_file = $self->{'_param_tmpdir'}."/genesplicer_$$.fa"; - open SEQ, ">$seq_file" or die("ERROR: Could not write to temporary sequence file $seq_file\n"); - print SEQ ">SEQ\n$seq\n"; - close SEQ; - - my $result_file = $self->{'_param_tmpdir'}."/genesplicer_$$.results"; - - my $cmd = sprintf( - '%s %s %s -f %s', - $self->{'_bin'}, - $seq_file, - $self->{'_training_dir'}, - $result_file - ); - - my $output = `$cmd 2>&1`; - unlink($seq_file); - - return [] unless -e $result_file; - - open RES, $result_file; - my @results; - - while(<RES>) { - chomp; - my ($end5, $end3, $score, $confidence, $type) = split; - - push @results, { - end5 => $end5, - end3 => $end3, - score => $score, - confidence => $confidence, - type => $type - }; - } - close RES; - - unlink($result_file); - - push @{$self->{cache}}, { hex => md5_hex($seq), results => \@results}; - shift @{$self->{cache}} while scalar @{$self->{cache}} > $self->{_param_cache_size}; - - return \@results; -} - -sub results_from_cache { - my $self = shift; - my $seq = shift; - - my ($results) = map {$_->{results}} grep {$_->{hex} eq md5_hex($seq)} @{$self->{cache} || []}; - - return $results; -} - -sub compare_results { - my $self = shift; - my $a = shift; - my $b = shift; - - my (@diff, @lost); - - foreach my $res_a(@$a) { - my @match = grep { - $_->{end5} == $res_a->{end5} && - $_->{end3} == $res_a->{end3} && - $_->{type} eq $res_a->{type} - } @$b; - - # result not found in b - if(!@match) { - push @lost, $res_a; - } - - # >1 result found - elsif(scalar @match > 1) { - warn("WARNING: Found two matches?\n"); - } - - # 1 match - elsif($match[0]->{score} != $res_a->{score}) { - my %diff = %$res_a; - $diff{score} .= '-'.$match[0]->{score}; - $diff{confidence} .= '-'.$match[0]->{confidence}; - push @diff, \%diff; - } - } - - return { diff => \@diff, lost => \@lost}; -} - -sub map_ss_coords { - my $self = shift; - my $res = shift; - my $vf = shift; - - my $return = {}; - - foreach my $coord(qw(end5 end3)) { - $return->{$coord} = (($res->{$coord} - $self->{'_param_context'}) + $vf->{start}) - 1; - } - - return $return; -} - -1; -
--- a/dir_plugins/HGVSReferenceBase.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,78 +0,0 @@ -=head1 LICENSE -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - http://www.apache.org/licenses/LICENSE-2.0 -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - HGVSReferenceBase - -=head1 SYNOPSIS - - mv HGVSReferenceBase.pm ~/.vep/Plugins - ./vep -i variations.vcf --cache --hgvs --plugin HGVSReferenceBase - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - reports the reference base for the variant, as used in the longer form. - of HGVS. To be used with --hgvs option. - -=cut - - -package HGVSReferenceBase; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; -use Bio::EnsEMBL::Variation::DBSQL::TranscriptVariationAdaptor; -use Bio::EnsEMBL::Variation::DBSQL::DBAdaptor; -use Bio::EnsEMBL::Variation::TranscriptVariationAllele; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['VariationFeature']; -} - -sub get_header_info { - my $self = shift; - - return { - 'HGVS_ref' => 'Reference base as may be reported in HGVS transcript level notation', - }; -} - -sub run { - my ($self, $tva) = @_; - - # check var class, this is only useful for deletions - # or duplications - a subset of insertions - return {} unless $tva->variation_feature->var_class() =~ /del|ins/; - - return $tva->hgvs_transcript_reference() ? {'HGVS_ref' => $tva->hgvs_transcript_reference()} : {}; - -} - -1;
--- a/dir_plugins/LD.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,277 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - LD - -=head1 SYNOPSIS - - mv LD.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin LD,1000GENOMES:phase_3:CEU,0.8 - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - finds variants in linkage disequilibrium with any overlapping existing - variants from the Ensembl variation databases. You can configure the - population used to calculate the r2 value, and the r2 cutoff used by - passing arguments to the plugin via the VEP command line (separated - by commas). This plugin adds a single new entry to the Extra column - with a comma-separated list of linked variant IDs and the associated - r2 values, e.g.: - - LinkedVariants=rs123:0.879,rs234:0.943 - - If no arguments are supplied, the default population used is the CEU - sample from the 1000 Genomes Project phase 3, and the default r2 - cutoff used is 0.8. - - WARNING: Calculating LD is a relatively slow procedure, so this will - slow VEP down considerably when running on large numbers of - variants. Consider running vep followed by filter_vep to get a smaller - input set: - - ./vep -i input.vcf -cache -vcf -o input_vep.vcf - ./filter_vep -i input_vep.vcf -filter "Consequence is missense_variant" > input_vep_filtered.vcf - ./vep -i input_vep_filtered.vcf -cache -plugin LD - -=cut - -=head1 INSTALLATION - - LD calculation requires additional installation steps. - - The JSON perl library is required; see VEP's installation instructions - for guidance: http://www.ensembl.org/info/docs/tools/vep/script/vep_download.html#additional - - A binary from the ensembl-variation git repository must be compiled and either - added to your PATH or specified on the command line. In the ensembl-vep - directory: - - export HTSLIB_DIR=${PWD}/htslib - git clone https://github.com/Ensembl/ensembl-variation - cd ensembl-variation/C_code - make - - You may EITHER add this path to your PATH environment variable (add this line - to your $HOME/.bashrc to make the change permanent): - - export PATH=${PATH}:${PWD} - - OR you may specify the full path to the ld_vcf binary on the vep command line: - - ./vep -i variations.vcf --plugin LD,1000GENOMES:phase_3:CEU,0.8,$PWD/ensembl-variation/C_code/ld_vcf - -=cut - -=head1 DATA - - By default genotype data to calculate LD is retrieved from tabix-indexed - VCF files hosted on Ensembl's FTP servers. It is possible to download this - data to your local machine and have the LD plugin read genotype data from - there instead, giving faster performance and reducing network traffic. - - These commands show how to get the data files for GRCh38. - - mkdir variation_genotype - cd variation_genotype - lftp -e "mget ALL.chr*.phase3_shapeit2_mvncall_integrated_v3plus_nounphased.rsID.genotypes.GRCh38_dbSNP.vcf.gz*" ftp://ftp.ensembl.org/pub/data_files/homo_sapiens/GRCh38/variation_genotype/ - cd .. - - For GRCh37 replace the lftp command with: - - lftp -e "mget ALL.chr*.phase3_shapeit2_mvncall_integrated_v3plus_nounphased.rsID.genotypes.vcf.gz*" ftp://ftp.ensembl.org/pub/data_files/homo_sapiens/GRCh37/variation_genotype/ - - We must now modify the JSON configuration file used to find the data. Starting - in the ensembl-vep directory: - - perl -pi -e "s|ftp://ftp.ensembl.org/pub/data_files/homo_sapiens/GRCh38|$PWD|" Bio/EnsEMBL/Variation/DBSQL/vcf_config.json - - Or for GRCh37: - - perl -pi -e "s|ftp://ftp.ensembl.org/pub/data_files/homo_sapiens/GRCh37|$PWD|" Bio/EnsEMBL/Variation/DBSQL/vcf_config.json - -=cut - -package LD; - -use strict; -use warnings; - -use Bio::EnsEMBL::Registry; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - - my $self = shift; - - return { - LinkedVariants => "Variants in LD (r2 >= ".$self->{r2_cutoff}. - ") with overlapping existing variants from the ". - $self->{pop}->name." population", - }; -} - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - if ($self->config->{offline}) { - warn "Warning: a connection to the database is required to calculate LD\n"; - } - - my $reg = 'Bio::EnsEMBL::Registry'; - - # turn on the check for existing variants - - $self->config->{check_existing} = 1; - - # fetch our population - - my ($pop_name, $r2_cutoff, $ld_binary) = @{ $self->params }; - - # set some defaults - - $pop_name ||= '1000GENOMES:phase_3:CEU'; - - $r2_cutoff = 0.8 unless defined $r2_cutoff; - - my $pop_adap = $reg->get_adaptor('human', 'variation', 'population') - || die "Failed to get population adaptor\n"; - - my $valid_pops = $pop_adap->fetch_all_LD_Populations(); - my ($pop) = grep {$_->name eq $pop_name} @$valid_pops; - die "Invalid population '$pop_name'; valid populations are:\n".join(", ", map {$_->name} @$valid_pops)."\n" unless $pop; - - $self->{pop} = $pop; - $self->{r2_cutoff} = $r2_cutoff; - - # prefetch the necessary adaptors - - my $ld_adap = $reg->get_adaptor('human', 'variation', 'ldfeaturecontainer') - || die "Failed to get LD adaptor\n"; - $ld_adap->db->use_vcf(1); - my $var_adap = $reg->get_adaptor('human', 'variation', 'variation') - || die "Failed to get variation adaptor\n"; - - my $var_feat_adap = $reg->get_adaptor('human', 'variation', 'variationfeature') - || die "Failed to get variation feature adaptor\n"; - - if($ld_binary) { - die("Specified LD binary \"$ld_binary\" does not exist\n") unless -e $ld_binary; - $Bio::EnsEMBL::Variation::DBSQL::LDFeatureContainerAdaptor::VCF_BINARY_FILE = $ld_binary; - } - - $self->{ld_adap} = $ld_adap; - $self->{var_adap} = $var_adap; - $self->{var_feat_adap} = $var_feat_adap; - - return $self; -} - -sub run { - my ($self, $vfoa, $line_hash) = @_; - - # fetch the existing variants from the line hash - return {} unless $line_hash->{Existing_variation}; - - my @vars = ref($line_hash->{Existing_variation}) eq 'ARRAY' ? @{$line_hash->{Existing_variation}} : split(',', $line_hash->{Existing_variation}); - - my @linked; - - - for my $var (@vars) { - - # check cache - my $res; - - if($self->{cache}) { - ($res) = grep {$_->{var} eq $var} @{$self->{cache}}; - } - - unless($res) { - my @this_linked; - - # fetch a variation for each overlapping variant ID - if (my $v = $self->{var_adap}->fetch_by_name($var)) { - - # and fetch the associated variation features - - for my $vf (@{ $self->{var_feat_adap}->fetch_all_by_Variation($v) }) { - - # we're only interested in variation features that overlap our variant - - if ($vf->slice->name eq $vfoa->variation_feature->slice->name) { - - # fetch an LD feature container for this variation feature and our preconfigured population - if (my $ldfc = $self->{ld_adap}->fetch_by_VariationFeature($vf, $self->{pop})) { - - # loop over all the linked variants - # we pass 1 to get_all_ld_values() so that it doesn't lazy load - # VariationFeature objects - we only need the name here anyway - for my $result (@{ $ldfc->get_all_ld_values(1) }) { - - # apply our r2 cutoff - - if ($result->{r2} >= $self->{r2_cutoff}) { - - my $v1 = $result->{variation_name1}; - my $v2 = $result->{variation_name2}; - - # I'm not sure which of these are the query variant, so just check the names - - my $linked = $v1 eq $var ? $v2 : $v1; - - push @this_linked, sprintf("%s:%.3f", $linked, $result->{r2}); - } - } - } - } - } - } - - # cache it - $res = { - var => $var, - linked => \@this_linked - }; - - push @{$self->{cache}}, $res; - shift @{$self->{cache}} while scalar @{$self->{cache}} > 50; - } - - push @linked, @{$res->{linked}}; - } - - return scalar @linked ? {LinkedVariants => join(',', @linked)} : {}; -} - -1; -
--- a/dir_plugins/LICENSE Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,202 +0,0 @@ - Apache License - Version 2.0, January 2004 - http://www.apache.org/licenses/ - - TERMS AND CONDITIONS FOR USE, REPRODUCTION, AND DISTRIBUTION - - 1. Definitions. - - "License" shall mean the terms and conditions for use, reproduction, - and distribution as defined by Sections 1 through 9 of this document. - - "Licensor" shall mean the copyright owner or entity authorized by - the copyright owner that is granting the License. - - "Legal Entity" shall mean the union of the acting entity and all - other entities that control, are controlled by, or are under common - control with that entity. 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We also recommend that a - file or class name and description of purpose be included on the - same "printed page" as the copyright notice for easier - identification within third-party archives. - - Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute - Copyright [2016-2018] EMBL-European Bioinformatics Institute - - Licensed under the Apache License, Version 2.0 (the "License"); - you may not use this file except in compliance with the License. - You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - - Unless required by applicable law or agreed to in writing, software - distributed under the License is distributed on an "AS IS" BASIS, - WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - See the License for the specific language governing permissions and - limitations under the License. \ No newline at end of file
--- a/dir_plugins/LOVD.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,128 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - LOVD - -=head1 SYNOPSIS - - mv LOVD.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin LOVD - -=head1 DESCRIPTION - - A VEP plugin that retrieves LOVD variation data from http://www.lovd.nl/. - - Please be aware that LOVD is a public resource of curated variants, therefore - please respect this resource and avoid intensive querying of their databases - using this plugin, as it will impact the availability of this resource for - others. - -=cut - -package LOVD; - -use strict; -use warnings; -use LWP::UserAgent; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '2.5'; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - LOVD => "LOVD variant ID", - }; -} - -sub run { - my ($self, $tva) = @_; - - $self->{has_cache} = 1; - - my %hg_assembly = ( 'grch37' => 'hg19', 'grch38' => 'hg38' ); - my $assembly = lc($self->{config}->{assembly}); - - # only works on human - die("ERROR: LOVD plugin works only on human data") unless $self->{config}->{species} =~ /human|homo/i; - - # only work on 2 human assemblies - die("ERROR: LOVD plugin works only on human assemblies ".join(' and ', keys(%hg_assembly))) unless $hg_assembly{$assembly}; - - # get the VF object - my $vf = $tva->variation_feature; - return {} unless defined $vf; - - # set up a LWP UserAgent - my $ua = LWP::UserAgent->new; - $ua->env_proxy; - - my $chr = $vf->{chr}; - $chr =~ s/^chr//; - - my $locus = sprintf('chr%s:%s_%s', $chr, $vf->{start}, $vf->{end}); - - my $data; - - # check the cache - if(!exists($self->{lovd_cache}->{$locus})) { - - # construct a LOVD URL - my $url = sprintf('http://www.lovd.nl/search.php?build=%s&position=%s', $hg_assembly{$assembly}, $locus); - - # get the accession (only need the head to get the redirect URL that contains the accession) - my $response = $ua->get($url); - - if($response->is_success) { - - # parse the data into a hash - for(grep {$_ !~ /hg_build/} split /\cJ/, $response->decoded_content) { - s/\"//g; - - my ($build, $pos, $gene, $acc, $dna, $url) = split /\t/; - - $data = join(',', $gene, $acc, $dna) - } - - $self->{lovd_cache}->{$locus} = $data; - } - } - else { - $data = $self->{lovd_cache}->{$locus}; - } - - return $data ? { LOVD => $data } : {}; -} - -1; -
--- a/dir_plugins/LoFtool.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,122 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - LoFtool - -=head1 SYNOPSIS - - mv LoFtool.pm ~/.vep/Plugins - mv LoFtool_scores.txt ~/.vep/Plugins - ./vep -i variants.vcf --plugin LoFtool - -=head1 DESCRIPTION - - Add LoFtool scores to the VEP output. - - LoFtool provides a rank of genic intolerance and consequent - susceptibility to disease based on the ratio of Loss-of-function (LoF) - to synonymous mutations for each gene in 60,706 individuals from ExAC, - adjusting for the gene de novo mutation rate and evolutionary protein - conservation. The lower the LoFtool gene score percentile the most - intolerant is the gene to functional variation. For more details please see - (Fadista J et al. 2017), PMID:27563026. - The authors would like to thank the Exome Aggregation Consortium and - the groups that provided exome variant data for comparison. A full - list of contributing groups can be found at http://exac.broadinstitute.org/about. - - The LoFtool_scores.txt file is found alongside the plugin in the - VEP_plugins GitHub repo. - - To use another scores file, add it as a parameter i.e. - - ./vep -i variants.vcf --plugin LoFtool,scores_file.txt - -=cut - -package LoFtool; - -use strict; -use warnings; - -use DBI; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $file = $self->params->[0]; - - if(!$file) { - my $plugin_dir = $INC{'LoFtool.pm'}; - $plugin_dir =~ s/LoFtool\.pm//i; - $file = $plugin_dir.'/LoFtool_scores.txt'; - } - - die("ERROR: LoFtool scores file $file not found\n") unless $file && -e $file; - - open IN, $file; - my %scores; - - while(<IN>) { - chomp; - my ($gene, $score) = split; - next if !defined($score) || $score eq 'LoFtool_percentile'; - $scores{lc($gene)} = sprintf("%g", $score); - } - - close IN; - - die("ERROR: No scores read from $file\n") unless scalar keys %scores; - - $self->{scores} = \%scores; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - LoFtool => "LoFtool score for gene" - }; -} - -sub run { - my $self = shift; - my $tva = shift; - - my $symbol = $tva->transcript->{_gene_symbol} || $tva->transcript->{_gene_hgnc}; - return {} unless $symbol; - - return $self->{scores}->{lc($symbol)} ? { LoFtool => $self->{scores}->{lc($symbol)}} : {}; -} - -1; -
--- a/dir_plugins/LoFtool_scores.txt Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,14516 +0,0 @@ -Gene LoFtool_percentile -NIPBL 6.89E-05 -SCN1A 1.38E-04 -NOTCH1 2.07E-04 -TSC2 2.76E-04 -PTCH1 3.44E-04 -SCN5A 4.13E-04 -EP300 4.82E-04 -CACNA1C 5.51E-04 -CACNA1G 6.20E-04 -SMARCA4 6.89E-04 -ATP2B3 7.58E-04 -KCNH2 8.27E-04 -FLNA 8.96E-04 -TP53 9.65E-04 -LMNA 1.03E-03 -CREBBP 1.10E-03 -RREB1 1.17E-03 -GRM7 1.24E-03 -CACNA1E 1.31E-03 -NAV1 1.38E-03 -SCN2A 1.45E-03 -DAG1 1.52E-03 -F8 1.58E-03 -MLH1 1.65E-03 -MGAT1 1.72E-03 -FGFR2 1.79E-03 -NSD1 1.86E-03 -RALGAPB 1.93E-03 -CASZ1 2.00E-03 -BRCA1 2.07E-03 -PSEN1 2.14E-03 -DYSF 2.20E-03 -KIT 2.27E-03 -NRXN3 2.34E-03 -KCNH4 2.41E-03 -RYR1 2.48E-03 -COL4A5 2.55E-03 -LRP1 2.62E-03 -FLNB 2.69E-03 -WHSC1 2.76E-03 -KCNQ2 2.82E-03 -FBN1 2.89E-03 -ATP1A3 2.96E-03 -HCFC1 3.03E-03 -ACTB 3.10E-03 -ESR1 3.17E-03 -RET 3.24E-03 -ABL1 3.31E-03 -SOX30 3.38E-03 -KCNQ1 3.44E-03 -NLRP3 3.51E-03 -DLL1 3.58E-03 -MECP2 3.65E-03 -COL6A3 3.72E-03 -FOXK1 3.79E-03 -APC 3.86E-03 -NUP98 3.93E-03 -ATP2B2 4.00E-03 -COL1A1 4.06E-03 -TBX3 4.13E-03 -CACNA1D 4.20E-03 -APP 4.27E-03 -LRP2 4.34E-03 -GRIK3 4.41E-03 -TRIM71 4.48E-03 -CAMTA1 4.55E-03 -SERPINA1 4.62E-03 -HELZ 4.68E-03 -CTNND2 4.75E-03 -DAB2IP 4.82E-03 -COL5A2 4.89E-03 -ZNF521 4.96E-03 -FUS 5.03E-03 -CACNA1H 5.10E-03 -ATRX 5.17E-03 -FGFR1 5.24E-03 -CASR 5.30E-03 -UBTF 5.37E-03 -TSC1 5.44E-03 -ATP2B1 5.51E-03 -ARSA 5.58E-03 -SERPING1 5.65E-03 -SCN4A 5.72E-03 -SRCAP 5.79E-03 -SCN3A 5.86E-03 -PCIF1 5.92E-03 -ZNF608 5.99E-03 -MYH9 6.06E-03 -MYH11 6.13E-03 -CHAT 6.20E-03 -JAG1 6.27E-03 -LIN54 6.34E-03 -COL2A1 6.41E-03 -DHX30 6.48E-03 -SETD1A 6.54E-03 -FLNC 6.61E-03 -TP63 6.68E-03 -ATP2A3 6.75E-03 -WFS1 6.82E-03 -ADNP 6.89E-03 -RLF 6.96E-03 -NUFIP2 7.03E-03 -COL1A2 7.10E-03 -MSL2 7.17E-03 -GCK 7.23E-03 -ATP1A1 7.30E-03 -ASH1L 7.37E-03 -OCRL 7.44E-03 -ZNF609 7.51E-03 -PAX7 7.58E-03 -EXT1 7.65E-03 -PKHD1 7.72E-03 -MGAT5 7.79E-03 -FBN2 7.85E-03 -SYK 7.92E-03 -RBM14 7.99E-03 -RB1 8.06E-03 -VCAN 8.13E-03 -ELFN2 8.20E-03 -GBA 8.27E-03 -GNAS 8.34E-03 -NF2 8.41E-03 -MGA 8.47E-03 -OPA1 8.54E-03 -SLC12A5 8.61E-03 -EEF1D 8.68E-03 -THRB 8.75E-03 -PC 8.82E-03 -EP400 8.89E-03 -SUPT5H 8.96E-03 -ATP2C1 9.03E-03 -SOX6 9.09E-03 -LRP1B 9.16E-03 -PAX3 9.23E-03 -ZNF592 9.30E-03 -KCNB1 9.37E-03 -COL11A1 9.44E-03 -HBB 9.51E-03 -JAG2 9.58E-03 -EIF4ENIF1 9.65E-03 -MSH2 9.71E-03 -GRM5 9.78E-03 -ABCA2 9.85E-03 -DNMT3B 9.92E-03 -PLEC 9.99E-03 -ERCC6L 1.01E-02 -PDZD8 1.01E-02 -KCNC1 1.02E-02 -PPARD 1.03E-02 -BEST1 1.03E-02 -MTA1 1.04E-02 -DPYSL5 1.05E-02 -CYBB 1.05E-02 -SMARCC2 1.06E-02 -ABCA4 1.07E-02 -NR1I3 1.07E-02 -DACH2 1.08E-02 -GLG1 1.09E-02 -EMR2 1.10E-02 -AHDC1 1.10E-02 -MLLT1 1.11E-02 -PPFIA3 1.12E-02 -PML 1.12E-02 -LRP8 1.13E-02 -COL5A1 1.14E-02 -CLCN2 1.14E-02 -LTBP1 1.15E-02 -MBD5 1.16E-02 -SNPH 1.16E-02 -TRPV4 1.17E-02 -GABRD 1.18E-02 -C11orf30 1.18E-02 -TMEM201 1.19E-02 -EYA1 1.20E-02 -SCN9A 1.21E-02 -KCNQ5 1.21E-02 -MTMR3 1.22E-02 -COL4A1 1.23E-02 -TNS1 1.23E-02 -ELANE 1.24E-02 -AR 1.25E-02 -NR5A1 1.25E-02 -COL6A2 1.26E-02 -ZNF777 1.27E-02 -LCOR 1.27E-02 -CACNB2 1.28E-02 -SYNPO 1.29E-02 -TENC1 1.30E-02 -SMARCAD1 1.30E-02 -ANKRD11 1.31E-02 -PAH 1.32E-02 -CACNA1I 1.32E-02 -ZNF827 1.33E-02 -PRKAG2 1.34E-02 -CLCN5 1.34E-02 -EZH2 1.35E-02 -HNF4A 1.36E-02 -MED13 1.36E-02 -CHD3 1.37E-02 -CDKN2AIP 1.38E-02 -RORC 1.38E-02 -DPYSL2 1.39E-02 -INTS6 1.40E-02 -FBN3 1.41E-02 -ITPR1 1.41E-02 -EFEMP1 1.42E-02 -RXRA 1.43E-02 -PRNP 1.43E-02 -CHD5 1.44E-02 -CRMP1 1.45E-02 -ACVR2B 1.45E-02 -GLI3 1.46E-02 -POLG 1.47E-02 -SAP130 1.47E-02 -CPS1 1.48E-02 -CSDE1 1.49E-02 -HIC2 1.50E-02 -NPC1L1 1.50E-02 -ABCA12 1.51E-02 -ABCC11 1.52E-02 -ZMYND8 1.52E-02 -SETDB1 1.53E-02 -LRP5 1.54E-02 -FOXM1 1.54E-02 -TBX18 1.55E-02 -RARB 1.56E-02 -NOTCH2 1.56E-02 -SCN8A 1.57E-02 -HIRA 1.58E-02 -FXN 1.58E-02 -CYB5R3 1.59E-02 -HIVEP2 1.60E-02 -WHSC1L1 1.61E-02 -CIC 1.61E-02 -LEF1 1.62E-02 -MBD1 1.63E-02 -MME 1.63E-02 -TFAP2A 1.64E-02 -SACS 1.65E-02 -CAND1 1.65E-02 -SLC8A2 1.66E-02 -INO80 1.67E-02 -SULF2 1.67E-02 -KCNE1 1.68E-02 -TAF3 1.69E-02 -G6PD 1.69E-02 -SULF1 1.70E-02 -RORA 1.71E-02 -POMT1 1.72E-02 -ABCB4 1.72E-02 -GRM1 1.73E-02 -CPT1B 1.74E-02 -SETD5 1.74E-02 -CSF2RA 1.75E-02 -COL27A1 1.76E-02 -RAP1GAP 1.76E-02 -HIPK1 1.77E-02 -XKR4 1.78E-02 -MFN2 1.78E-02 -TP73 1.79E-02 -NR4A2 1.80E-02 -SBNO1 1.81E-02 -L1CAM 1.81E-02 -THOC2 1.82E-02 -EHMT1 1.83E-02 -FOXA2 1.83E-02 -EIF3A 1.84E-02 -WBP11 1.85E-02 -GABRA1 1.85E-02 -NNT 1.86E-02 -ZEB2 1.87E-02 -CDC42BPB 1.87E-02 -ABCD1 1.88E-02 -MED1 1.89E-02 -KCNJ11 1.89E-02 -TH 1.90E-02 -NEFM 1.91E-02 -DYNC1H1 1.92E-02 -ADARB1 1.92E-02 -FRMPD4 1.93E-02 -ABCC6 1.94E-02 -BCL11A 1.94E-02 -ITGB1 1.95E-02 -HEPH 1.96E-02 -NELL2 1.96E-02 -ATP7A 1.97E-02 -CAPN3 1.98E-02 -SLC4A4 1.98E-02 -GNAI2 1.99E-02 -ERF 2.00E-02 -NTRK2 2.00E-02 -TRAPPC9 2.01E-02 -ACTL6A 2.02E-02 -FBLN1 2.03E-02 -AMPD3 2.03E-02 -SAFB 2.04E-02 -GFAP 2.05E-02 -APLP2 2.05E-02 -COL11A2 2.06E-02 -SLC7A2 2.07E-02 -COL3A1 2.07E-02 -GNA11 2.08E-02 -SERBP1 2.09E-02 -PRKCE 2.09E-02 -NPHP4 2.10E-02 -DCTN1 2.11E-02 -BRAF 2.12E-02 -MSH6 2.12E-02 -YAP1 2.13E-02 -QRICH1 2.14E-02 -LRRC4 2.14E-02 -ARID1A 2.15E-02 -SUPT6H 2.16E-02 -ECE1 2.16E-02 -SRC 2.17E-02 -UPF1 2.18E-02 -EFTUD2 2.18E-02 -SMC1A 2.19E-02 -SOBP 2.20E-02 -ATP2A2 2.20E-02 -EIF2B5 2.21E-02 -TRIM46 2.22E-02 -TRPS1 2.23E-02 -TRPC5 2.23E-02 -LBR 2.24E-02 -SF1 2.25E-02 -FGFR3 2.25E-02 -KCNJ2 2.26E-02 -FLT4 2.27E-02 -ABCB1 2.27E-02 -SLC12A3 2.28E-02 -KIAA0430 2.29E-02 -EPB41L2 2.29E-02 -FURIN 2.30E-02 -MAP2K7 2.31E-02 -TFAP2D 2.31E-02 -PSEN2 2.32E-02 -BTAF1 2.33E-02 -CHD1 2.34E-02 -MYOCD 2.34E-02 -CFTR 2.35E-02 -UBAP2L 2.36E-02 -NCAPH2 2.36E-02 -ITGB8 2.37E-02 -MYCN 2.38E-02 -TNFRSF25 2.38E-02 -GNAZ 2.39E-02 -GABRA4 2.40E-02 -ACTN4 2.40E-02 -SLC26A1 2.41E-02 -LRRC4C 2.42E-02 -NFIL3 2.43E-02 -MUTYH 2.43E-02 -KRT6A 2.44E-02 -SETX 2.45E-02 -THRA 2.45E-02 -KCNMA1 2.46E-02 -NRP2 2.47E-02 -MOV10L1 2.47E-02 -MAML1 2.48E-02 -QKI 2.49E-02 -SOS1 2.49E-02 -C10orf2 2.50E-02 -HMBS 2.51E-02 -SYNJ1 2.51E-02 -GATA3 2.52E-02 -SMAD1 2.53E-02 -SLC12A6 2.54E-02 -ZNF652 2.54E-02 -CLTA 2.55E-02 -CPSF7 2.56E-02 -GNAL 2.56E-02 -KCNC2 2.57E-02 -KIF11 2.58E-02 -SKIL 2.58E-02 -BNC1 2.59E-02 -MYO7A 2.60E-02 -ZC3H10 2.60E-02 -XPO4 2.61E-02 -FOXP3 2.62E-02 -ANKRD17 2.62E-02 -NR0B1 2.63E-02 -GRAMD4 2.64E-02 -EXOC7 2.65E-02 -DCX 2.65E-02 -LYN 2.66E-02 -SNRK 2.67E-02 -NFRKB 2.67E-02 -TCF7L2 2.68E-02 -NMNAT2 2.69E-02 -WDR20 2.69E-02 -PAX8 2.70E-02 -HNRNPUL1 2.71E-02 -IRF2BP1 2.71E-02 -KCNA2 2.72E-02 -RANBP3 2.73E-02 -ABCA3 2.74E-02 -PARP8 2.74E-02 -ZNF445 2.75E-02 -DEDD 2.76E-02 -SMOX 2.76E-02 -PAX5 2.77E-02 -XKR7 2.78E-02 -GCH1 2.78E-02 -FASN 2.79E-02 -GDNF 2.80E-02 -TRIM33 2.80E-02 -CPEB1 2.81E-02 -SLC12A4 2.82E-02 -COL4A6 2.82E-02 -CHD7 2.83E-02 -KCNH6 2.84E-02 -JMJD1C 2.85E-02 -RAB11FIP4 2.85E-02 -TKTL1 2.86E-02 -ZBED4 2.87E-02 -ZC3H14 2.87E-02 -KCND3 2.88E-02 -ATP13A2 2.89E-02 -SLC26A9 2.89E-02 -MTSS1 2.90E-02 -GRM8 2.91E-02 -PTCH2 2.91E-02 -MYH14 2.92E-02 -SOCS6 2.93E-02 -LHX6 2.93E-02 -SETD2 2.94E-02 -DLL4 2.95E-02 -FKBP8 2.96E-02 -MOV10 2.96E-02 -SETBP1 2.97E-02 -DHRS3 2.98E-02 -NR3C2 2.98E-02 -ABCB9 2.99E-02 -RALGAPA1 3.00E-02 -CACNA1S 3.00E-02 -EPB41L4B 3.01E-02 -ONECUT1 3.02E-02 -CTBP2 3.02E-02 -ADCY9 3.03E-02 -NACC1 3.04E-02 -CBS 3.05E-02 -IPO7 3.05E-02 -VWF 3.06E-02 -FBXL16 3.07E-02 -FOXA3 3.07E-02 -ABCF2 3.08E-02 -PSMD2 3.09E-02 -DGCR8 3.09E-02 -GANAB 3.10E-02 -PRPF3 3.11E-02 -VDR 3.11E-02 -ATP2B4 3.12E-02 -SERPINF2 3.13E-02 -EIF2B4 3.13E-02 -ABCB5 3.14E-02 -GAA 3.15E-02 -SLC26A11 3.16E-02 -ENG 3.16E-02 -LRP4 3.17E-02 -ZIC1 3.18E-02 -PHKA1 3.18E-02 -CHST1 3.19E-02 -ZMYM3 3.20E-02 -DHCR24 3.20E-02 -ACTG1 3.21E-02 -KCNH3 3.22E-02 -SLITRK1 3.22E-02 -SUV420H1 3.23E-02 -KCNH5 3.24E-02 -C17orf85 3.24E-02 -PYGB 3.25E-02 -NCKAP1 3.26E-02 -TNFRSF1A 3.27E-02 -PRDM1 3.27E-02 -SQSTM1 3.28E-02 -KCNJ1 3.29E-02 -STC2 3.29E-02 -CTCF 3.30E-02 -MYO1C 3.31E-02 -ZNFX1 3.31E-02 -IRF6 3.32E-02 -KRT18 3.33E-02 -ITGB2 3.33E-02 -RPTOR 3.34E-02 -PHF12 3.35E-02 -SPAST 3.36E-02 -ATP6V0A4 3.36E-02 -CENPI 3.37E-02 -ESRRG 3.38E-02 -CPT1A 3.38E-02 -ABCA7 3.39E-02 -SATB2 3.40E-02 -ATP7B 3.40E-02 -NR4A3 3.41E-02 -ATP6AP1 3.42E-02 -MTMR4 3.42E-02 -SLC2A13 3.43E-02 -PRPF4B 3.44E-02 -KDM2A 3.44E-02 -FOXI1 3.45E-02 -HDAC6 3.46E-02 -ARIH1 3.47E-02 -ZNF423 3.47E-02 -ALKBH5 3.48E-02 -PLS3 3.49E-02 -STXBP1 3.49E-02 -PPP2R5E 3.50E-02 -PRF1 3.51E-02 -RYR3 3.51E-02 -TFAP2C 3.52E-02 -GRM4 3.53E-02 -COLEC12 3.53E-02 -EFNB2 3.54E-02 -COL13A1 3.55E-02 -PIK3AP1 3.55E-02 -CCT3 3.56E-02 -AGL 3.57E-02 -NOTCH3 3.58E-02 -SEC61A1 3.58E-02 -STAT3 3.59E-02 -LARP4B 3.60E-02 -MYH2 3.60E-02 -GAPVD1 3.61E-02 -TAF5L 3.62E-02 -MED13L 3.62E-02 -CCDC120 3.63E-02 -PPHLN1 3.64E-02 -VHL 3.64E-02 -C14orf80 3.65E-02 -LAS1L 3.66E-02 -PRKG1 3.67E-02 -EPB41 3.67E-02 -KCNH1 3.68E-02 -ONECUT2 3.69E-02 -GATA1 3.69E-02 -SIX2 3.70E-02 -COL7A1 3.71E-02 -GRID2 3.71E-02 -TRIM9 3.72E-02 -ZMIZ2 3.73E-02 -TMEM115 3.73E-02 -NKX2-5 3.74E-02 -NRF1 3.75E-02 -INSR 3.75E-02 -SH3BP2 3.76E-02 -EXT2 3.77E-02 -MGAT3 3.78E-02 -ACAN 3.78E-02 -ABCC3 3.79E-02 -HNF1B 3.80E-02 -DDHD1 3.80E-02 -ZNF296 3.81E-02 -SCN10A 3.82E-02 -ANKRD34A 3.82E-02 -ALDOA 3.83E-02 -INS 3.84E-02 -KRT5 3.84E-02 -MEF2D 3.85E-02 -STAT6 3.86E-02 -KCNJ6 3.86E-02 -DHCR7 3.87E-02 -ABCA1 3.88E-02 -MAPK8IP1 3.89E-02 -EBF3 3.89E-02 -LPHN1 3.90E-02 -TLX3 3.91E-02 -VLDLR 3.91E-02 -RANBP9 3.92E-02 -SCUBE3 3.93E-02 -FBXL14 3.93E-02 -NTRK3 3.94E-02 -CUL4A 3.95E-02 -NTRK1 3.95E-02 -MNT 3.96E-02 -PROX1 3.97E-02 -FBLN5 3.98E-02 -TRAM2 3.98E-02 -NR1D1 3.99E-02 -TJAP1 4.00E-02 -MKL2 4.00E-02 -CRB1 4.01E-02 -LRP6 4.02E-02 -NEUROD2 4.02E-02 -GPKOW 4.03E-02 -VANGL2 4.04E-02 -GJC1 4.04E-02 -ZDHHC5 4.05E-02 -SLC26A5 4.06E-02 -TRRAP 4.06E-02 -FBXO18 4.07E-02 -GALT 4.08E-02 -PAX6 4.09E-02 -KPNB1 4.09E-02 -C19orf12 4.10E-02 -ESR2 4.11E-02 -TMEM200A 4.11E-02 -MYH7 4.12E-02 -JARID2 4.13E-02 -OTX1 4.13E-02 -ABCA13 4.14E-02 -NDST1 4.15E-02 -MLLT3 4.15E-02 -MSH5 4.16E-02 -INF2 4.17E-02 -TNS3 4.17E-02 -IHH 4.18E-02 -RFX4 4.19E-02 -ADNP2 4.20E-02 -SPG20 4.20E-02 -CTSB 4.21E-02 -BRF1 4.22E-02 -PYGM 4.22E-02 -ABCC8 4.23E-02 -KCNQ4 4.24E-02 -SLC3A2 4.24E-02 -SF3A3 4.25E-02 -DDR2 4.26E-02 -SLC7A3 4.26E-02 -KRT72 4.27E-02 -ARC 4.28E-02 -DDR1 4.29E-02 -ALAS1 4.29E-02 -SLC26A8 4.30E-02 -FZR1 4.31E-02 -MBP 4.31E-02 -LDB2 4.32E-02 -INHBA 4.33E-02 -PLK2 4.33E-02 -PCYT1B 4.34E-02 -SMPD1 4.35E-02 -ACVR1B 4.35E-02 -GNE 4.36E-02 -ABCA5 4.37E-02 -GNAI1 4.37E-02 -BANP 4.38E-02 -SMPD4 4.39E-02 -ATP6V0A1 4.40E-02 -RGMA 4.40E-02 -ABCC4 4.41E-02 -GH1 4.42E-02 -RNF8 4.42E-02 -COL6A1 4.43E-02 -TRAF6 4.44E-02 -FOXK2 4.44E-02 -GPM6A 4.45E-02 -TPM1 4.46E-02 -ADARB2 4.46E-02 -ALPL 4.47E-02 -SMARCA1 4.48E-02 -EPB41L1 4.49E-02 -RUNX2 4.49E-02 -RFX1 4.50E-02 -TPTE 4.51E-02 -SLC20A2 4.51E-02 -MYO9A 4.52E-02 -CASKIN2 4.53E-02 -TRIP12 4.53E-02 -C20orf112 4.54E-02 -VIM 4.55E-02 -EGFR 4.55E-02 -LEO1 4.56E-02 -GPR6 4.57E-02 -TEK 4.57E-02 -PRMT1 4.58E-02 -KIAA1432 4.59E-02 -KCNJ15 4.60E-02 -DCAF15 4.60E-02 -ACACA 4.61E-02 -PID1 4.62E-02 -RHBDD2 4.62E-02 -INHA 4.63E-02 -GLB1 4.64E-02 -TEX10 4.64E-02 -TAGLN 4.65E-02 -CAV3 4.66E-02 -GBX2 4.66E-02 -PHOX2B 4.67E-02 -TRIB2 4.68E-02 -CLCN7 4.68E-02 -CDK5R1 4.69E-02 -KIAA0232 4.70E-02 -DACH1 4.71E-02 -SRPR 4.71E-02 -DNMT1 4.72E-02 -TNPO1 4.73E-02 -GPHN 4.73E-02 -ZZZ3 4.74E-02 -MBD3 4.75E-02 -PAPD7 4.75E-02 -INTS5 4.76E-02 -ABCC9 4.77E-02 -FSCN1 4.77E-02 -MYO15A 4.78E-02 -NCDN 4.79E-02 -SALL1 4.80E-02 -BEND3 4.80E-02 -FAM160B1 4.81E-02 -PTPN11 4.82E-02 -ZNF407 4.82E-02 -DPF1 4.83E-02 -CRY2 4.84E-02 -TCEB3 4.84E-02 -ITPR3 4.85E-02 -KTN1 4.86E-02 -BMP10 4.86E-02 -NCBP1 4.87E-02 -C11orf57 4.88E-02 -COL12A1 4.88E-02 -RYR2 4.89E-02 -TCIRG1 4.90E-02 -TCF7 4.91E-02 -SMARCD1 4.91E-02 -SLAIN1 4.92E-02 -VANGL1 4.93E-02 -MTM1 4.93E-02 -CS 4.94E-02 -FAM101A 4.95E-02 -EGF 4.95E-02 -SMC3 4.96E-02 -MMP14 4.97E-02 -ASL 4.97E-02 -PSMD4 4.98E-02 -RLIM 4.99E-02 -GUCY1A3 4.99E-02 -PPARGC1A 5.00E-02 -FGFR4 5.01E-02 -RBM17 5.02E-02 -TAS1R1 5.02E-02 -CAPZA1 5.03E-02 -FLRT1 5.04E-02 -IGF2 5.04E-02 -SCUBE1 5.05E-02 -KCNH7 5.06E-02 -CNGA3 5.06E-02 -CD47 5.07E-02 -CCDC101 5.08E-02 -TRERF1 5.08E-02 -SOX5 5.09E-02 -ARID5A 5.10E-02 -TNFRSF21 5.11E-02 -GPS1 5.11E-02 -RUNX3 5.12E-02 -MAP2K2 5.13E-02 -MED15 5.13E-02 -NR2E1 5.14E-02 -HAS2 5.15E-02 -BMPR2 5.15E-02 -SMARCA5 5.16E-02 -RTEL1 5.17E-02 -PHF21A 5.17E-02 -KRT14 5.18E-02 -PSMD3 5.19E-02 -PHKA2 5.19E-02 -ABI1 5.20E-02 -THAP4 5.21E-02 -FOXJ2 5.22E-02 -PYGL 5.22E-02 -SBNO2 5.23E-02 -CALR 5.24E-02 -NDUFS2 5.24E-02 -PELI2 5.25E-02 -TRPC4AP 5.26E-02 -MYO9B 5.26E-02 -HMBOX1 5.27E-02 -LRRC4B 5.28E-02 -SGCA 5.28E-02 -MAP3K12 5.29E-02 -COPS4 5.30E-02 -PKHD1L1 5.30E-02 -RNF220 5.31E-02 -MAP2K1 5.32E-02 -ZAP70 5.33E-02 -KCNC4 5.33E-02 -POSTN 5.34E-02 -RER1 5.35E-02 -MON1B 5.35E-02 -NIPA2 5.36E-02 -PRKAR1A 5.37E-02 -EYS 5.37E-02 -HECA 5.38E-02 -CRK 5.39E-02 -SLC7A14 5.39E-02 -PDHA1 5.40E-02 -STAB1 5.41E-02 -FA2H 5.42E-02 -FOXN3 5.42E-02 -TGFBR1 5.43E-02 -NR6A1 5.44E-02 -SHOC2 5.44E-02 -MYO18B 5.45E-02 -ZNF362 5.46E-02 -APLP1 5.46E-02 -SF3B2 5.47E-02 -GATAD2B 5.48E-02 -PIAS1 5.48E-02 -TEF 5.49E-02 -DYRK2 5.50E-02 -MBD6 5.50E-02 -PHB 5.51E-02 -HK1 5.52E-02 -ATP6V1E1 5.53E-02 -POU4F2 5.53E-02 -SUMF1 5.54E-02 -DDX3X 5.55E-02 -RARG 5.55E-02 -AGXT 5.56E-02 -DIO3 5.57E-02 -TTR 5.57E-02 -NR4A1 5.58E-02 -STARD3 5.59E-02 -LTBP3 5.59E-02 -TDRD3 5.60E-02 -KCNK9 5.61E-02 -ABCB7 5.61E-02 -PHKB 5.62E-02 -FBXW7 5.63E-02 -PRKAR1B 5.64E-02 -KRT1 5.64E-02 -BLNK 5.65E-02 -NFKBIA 5.66E-02 -KIAA0355 5.66E-02 -SLC7A1 5.67E-02 -CHD4 5.68E-02 -SPATS2L 5.68E-02 -NES 5.69E-02 -NFE2 5.70E-02 -KCND1 5.70E-02 -COPB1 5.71E-02 -LDB1 5.72E-02 -DSPP 5.73E-02 -CACNA1F 5.73E-02 -CASK 5.74E-02 -GABBR1 5.75E-02 -DUOX1 5.75E-02 -UHRF2 5.76E-02 -GRIA1 5.77E-02 -LHX5 5.77E-02 -PTGER4 5.78E-02 -HNF1A 5.79E-02 -KLK11 5.79E-02 -ATP12A 5.80E-02 -NXPH3 5.81E-02 -TFCP2L1 5.81E-02 -RELB 5.82E-02 -MAPK8IP3 5.83E-02 -GPI 5.84E-02 -FZD4 5.84E-02 -LITAF 5.85E-02 -NARG2 5.86E-02 -TBX22 5.86E-02 -DNAJC6 5.87E-02 -PARK2 5.88E-02 -CELF5 5.88E-02 -LINGO2 5.89E-02 -DLGAP3 5.90E-02 -SERPINA5 5.90E-02 -KDM5A 5.91E-02 -MFAP3L 5.92E-02 -FOXN1 5.92E-02 -MTMR10 5.93E-02 -OLFM2 5.94E-02 -DDAH2 5.95E-02 -FHL2 5.95E-02 -SCO2 5.96E-02 -CLCN3 5.97E-02 -TCF20 5.97E-02 -MRTO4 5.98E-02 -LTBP2 5.99E-02 -KCNJ12 5.99E-02 -PPARA 6.00E-02 -AMPD2 6.01E-02 -TGFBR2 6.01E-02 -PREPL 6.02E-02 -RAB11B 6.03E-02 -GRIA2 6.04E-02 -HK3 6.04E-02 -MSI1 6.05E-02 -COL5A3 6.06E-02 -TAP2 6.06E-02 -S1PR4 6.07E-02 -USP7 6.08E-02 -DLK2 6.08E-02 -PKLR 6.09E-02 -CD248 6.10E-02 -FAM19A5 6.10E-02 -FOXP1 6.11E-02 -UBR5 6.12E-02 -IGF2BP3 6.12E-02 -CRKL 6.13E-02 -SERPINI1 6.14E-02 -NRP1 6.15E-02 -KRT13 6.15E-02 -DAXX 6.16E-02 -IMPDH1 6.17E-02 -MDH1 6.17E-02 -FADD 6.18E-02 -USP51 6.19E-02 -HIST1H2AE 6.19E-02 -GRM6 6.20E-02 -ACADVL 6.21E-02 -GALE 6.21E-02 -POLDIP3 6.22E-02 -LMX1A 6.23E-02 -COL8A1 6.23E-02 -EZR 6.24E-02 -ROR2 6.25E-02 -PHEX 6.26E-02 -CSF1 6.26E-02 -BCOR 6.27E-02 -FAS 6.28E-02 -DMRT1 6.28E-02 -DISP1 6.29E-02 -DNM1 6.30E-02 -NR2C2 6.30E-02 -TNFSF9 6.31E-02 -SLC12A1 6.32E-02 -BGN 6.32E-02 -NEUROD6 6.33E-02 -CTNS 6.34E-02 -PPARG 6.35E-02 -ZC3H4 6.35E-02 -KDM5C 6.36E-02 -CPEB3 6.37E-02 -MTMR9 6.37E-02 -HNRNPH1 6.38E-02 -SMARCE1 6.39E-02 -NR1H3 6.39E-02 -PITPNM3 6.40E-02 -SSRP1 6.41E-02 -NUP153 6.41E-02 -IRF5 6.42E-02 -ACTR3 6.43E-02 -SMARCAL1 6.43E-02 -PEX5 6.44E-02 -CTBP1 6.45E-02 -NAIF1 6.46E-02 -CNGA2 6.46E-02 -DNER 6.47E-02 -NCAN 6.48E-02 -SBF1 6.48E-02 -XRCC6 6.49E-02 -KIAA1644 6.50E-02 -WIZ 6.50E-02 -GDI2 6.51E-02 -SULT2B1 6.52E-02 -ARHGEF9 6.52E-02 -SCN1B 6.53E-02 -PRPS2 6.54E-02 -TUB 6.54E-02 -F7 6.55E-02 -LRRC8A 6.56E-02 -KCNA6 6.57E-02 -NR3C1 6.57E-02 -CBX2 6.58E-02 -FIGN 6.59E-02 -KCNS2 6.59E-02 -CANT1 6.60E-02 -UBA2 6.61E-02 -OGDHL 6.61E-02 -CDAN1 6.62E-02 -CAV1 6.63E-02 -CPT1C 6.63E-02 -TXLNA 6.64E-02 -ARID5B 6.65E-02 -TPP2 6.66E-02 -ERCC6 6.66E-02 -LRTM2 6.67E-02 -YTHDF2 6.68E-02 -MAPT 6.68E-02 -ABCC10 6.69E-02 -NMT1 6.70E-02 -CLCNKA 6.70E-02 -COL9A1 6.71E-02 -CYLD 6.72E-02 -FLAD1 6.72E-02 -TBX21 6.73E-02 -RERE 6.74E-02 -KHDRBS1 6.74E-02 -CDK19 6.75E-02 -ARGLU1 6.76E-02 -EPC1 6.77E-02 -STRA6 6.77E-02 -HMGB2 6.78E-02 -LIN28B 6.79E-02 -DLGAP1 6.79E-02 -DUSP6 6.80E-02 -COL22A1 6.81E-02 -HLCS 6.81E-02 -GPSM1 6.82E-02 -TFAP2B 6.83E-02 -GRM2 6.83E-02 -MYH6 6.84E-02 -ANGPT1 6.85E-02 -SMAD3 6.85E-02 -AIPL1 6.86E-02 -ZNF574 6.87E-02 -SRRT 6.88E-02 -EWSR1 6.88E-02 -SLC30A10 6.89E-02 -CTSA 6.90E-02 -GABRB1 6.90E-02 -PRRX1 6.91E-02 -EPAS1 6.92E-02 -SUOX 6.92E-02 -AKAP13 6.93E-02 -AGT 6.94E-02 -FZD5 6.94E-02 -NPC1 6.95E-02 -INPP5K 6.96E-02 -HOXD3 6.97E-02 -KCNN3 6.97E-02 -MVK 6.98E-02 -LYPLA2 6.99E-02 -SLC4A2 6.99E-02 -KLF12 7.00E-02 -NOL4 7.01E-02 -FAM163A 7.01E-02 -BMP6 7.02E-02 -RTF1 7.03E-02 -VCPIP1 7.03E-02 -PAFAH1B1 7.04E-02 -RC3H2 7.05E-02 -NKD1 7.05E-02 -TMEM63B 7.06E-02 -STMN1 7.07E-02 -TMEM169 7.08E-02 -BSCL2 7.08E-02 -NOG 7.09E-02 -EXOC4 7.10E-02 -EHD2 7.10E-02 -KCND2 7.11E-02 -YY2 7.12E-02 -RRAGD 7.12E-02 -KCNK10 7.13E-02 -FASLG 7.14E-02 -FRMD4A 7.14E-02 -SGTA 7.15E-02 -FAM168A 7.16E-02 -TFEB 7.17E-02 -TNFSF11 7.17E-02 -ACE2 7.18E-02 -ATP6V1H 7.19E-02 -VASH2 7.19E-02 -FBLN2 7.20E-02 -MYO1B 7.21E-02 -TRABD 7.21E-02 -LIMS2 7.22E-02 -STX1B 7.23E-02 -RARA 7.23E-02 -KIF26B 7.24E-02 -TRMT1 7.25E-02 -UNC5A 7.25E-02 -MCFD2 7.26E-02 -PPOX 7.27E-02 -GRM3 7.28E-02 -WNT3 7.28E-02 -NR2C1 7.29E-02 -SUMF2 7.30E-02 -SEPT8 7.30E-02 -OPTN 7.31E-02 -PKNOX2 7.32E-02 -HTR1B 7.32E-02 -ST14 7.33E-02 -LDB3 7.34E-02 -STT3B 7.34E-02 -TMEM11 7.35E-02 -PRPF4 7.36E-02 -KDM4B 7.36E-02 -LDLR 7.37E-02 -YME1L1 7.38E-02 -ERG 7.39E-02 -EDN3 7.39E-02 -CHRNB2 7.40E-02 -TM9SF3 7.41E-02 -RTN4RL1 7.41E-02 -TMPRSS9 7.42E-02 -PITX2 7.43E-02 -DOT1L 7.43E-02 -CCT5 7.44E-02 -TOMM70A 7.45E-02 -PBRM1 7.45E-02 -C11orf87 7.46E-02 -FH 7.47E-02 -FZD2 7.48E-02 -MAT1A 7.48E-02 -FOXP4 7.49E-02 -DLX5 7.50E-02 -BBX 7.50E-02 -SIAH2 7.51E-02 -MAPK1IP1L 7.52E-02 -CLPTM1 7.52E-02 -GABRG2 7.53E-02 -NOX4 7.54E-02 -NRIP1 7.54E-02 -C6orf106 7.55E-02 -TSHZ1 7.56E-02 -PRICKLE2 7.56E-02 -S1PR1 7.57E-02 -SLC12A2 7.58E-02 -NFIB 7.59E-02 -GABRB2 7.59E-02 -FERMT2 7.60E-02 -PMP22 7.61E-02 -ACVR1C 7.61E-02 -CEND1 7.62E-02 -CLVS1 7.63E-02 -PAX9 7.63E-02 -B4GALT5 7.64E-02 -TMEM204 7.65E-02 -DCAF10 7.65E-02 -EXOC1 7.66E-02 -LHX1 7.67E-02 -ECE2 7.67E-02 -NID1 7.68E-02 -MAP3K7 7.69E-02 -FBXO28 7.70E-02 -DSP 7.70E-02 -STAB2 7.71E-02 -SASH3 7.72E-02 -PRICKLE1 7.72E-02 -SLC5A1 7.73E-02 -SCN11A 7.74E-02 -MPP1 7.74E-02 -SLC26A6 7.75E-02 -ETS2 7.76E-02 -IGHMBP2 7.76E-02 -PAFAH1B2 7.77E-02 -DMAP1 7.78E-02 -ACTR2 7.79E-02 -ETV5 7.79E-02 -COLQ 7.80E-02 -AQR 7.81E-02 -ACVR2A 7.81E-02 -NFIA 7.82E-02 -GLRA1 7.83E-02 -ACVRL1 7.83E-02 -GIMAP1 7.84E-02 -CLK2 7.85E-02 -CNNM2 7.85E-02 -CAMK1D 7.86E-02 -PSMD1 7.87E-02 -TNFSF8 7.87E-02 -ADCY7 7.88E-02 -TLK1 7.89E-02 -SNX30 7.90E-02 -ABCF3 7.90E-02 -KCNA1 7.91E-02 -PANK4 7.92E-02 -NUP85 7.92E-02 -EDC4 7.93E-02 -RAB6B 7.94E-02 -CLCN1 7.94E-02 -SLC5A9 7.95E-02 -OTUD7A 7.96E-02 -POU2AF1 7.96E-02 -TRIM3 7.97E-02 -SLC7A5 7.98E-02 -GHDC 7.98E-02 -UTP15 7.99E-02 -COL21A1 8.00E-02 -EXOSC10 8.01E-02 -GH2 8.01E-02 -ABCC1 8.02E-02 -TBL1X 8.03E-02 -FNTA 8.03E-02 -PTPN2 8.04E-02 -ATP2A1 8.05E-02 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8.47E-02 -GPR143 8.48E-02 -GCAT 8.49E-02 -LETM1 8.49E-02 -GRIN2A 8.50E-02 -EXTL3 8.51E-02 -ZNF280C 8.52E-02 -RCL1 8.52E-02 -AMMECR1 8.53E-02 -FCGRT 8.54E-02 -CLDN19 8.54E-02 -ELF2 8.55E-02 -STAU1 8.56E-02 -ACRC 8.56E-02 -ARHGAP4 8.57E-02 -ABCA6 8.58E-02 -DNAJA2 8.58E-02 -KRT10 8.59E-02 -ZFHX3 8.60E-02 -ACTR3B 8.60E-02 -CHD2 8.61E-02 -MYO5B 8.62E-02 -F5 8.63E-02 -ITGB4 8.63E-02 -GJB6 8.64E-02 -RNF19A 8.65E-02 -TAP1 8.65E-02 -KCNV1 8.66E-02 -CBLN2 8.67E-02 -LCP1 8.67E-02 -PTPRD 8.68E-02 -BRE 8.69E-02 -TMPPE 8.69E-02 -ZC4H2 8.70E-02 -ARHGDIG 8.71E-02 -WDTC1 8.72E-02 -SOX7 8.72E-02 -HSF1 8.73E-02 -TAZ 8.74E-02 -H6PD 8.74E-02 -SORL1 8.75E-02 -LRP12 8.76E-02 -SERPINB8 8.76E-02 -CHD9 8.77E-02 -RHOG 8.78E-02 -OCA2 8.78E-02 -GUCY1A2 8.79E-02 -RXRG 8.80E-02 -SMS 8.80E-02 -SETDB2 8.81E-02 -MAPRE2 8.82E-02 -GIGYF1 8.83E-02 -ZHX2 8.83E-02 -MFGE8 8.84E-02 -SYMPK 8.85E-02 -ARSD 8.85E-02 -FIGNL1 8.86E-02 -SPRY2 8.87E-02 -MRPL4 8.87E-02 -MAGEB6 8.88E-02 -MBTPS2 8.89E-02 -KRT80 8.89E-02 -SLC40A1 8.90E-02 -H1F0 8.91E-02 -GUSB 8.91E-02 -MAPRE1 8.92E-02 -SLC26A4 8.93E-02 -LPPR5 8.94E-02 -ATP6V0C 8.94E-02 -INPPL1 8.95E-02 -BRCA2 8.96E-02 -GNPTAB 8.96E-02 -PREX1 8.97E-02 -SLC30A4 8.98E-02 -PTPRT 8.98E-02 -SI 8.99E-02 -RAB33B 9.00E-02 -ARL4C 9.00E-02 -SLC2A1 9.01E-02 -FBXO31 9.02E-02 -D2HGDH 9.03E-02 -MYOF 9.03E-02 -GLUD2 9.04E-02 -GCDH 9.05E-02 -KRT2 9.05E-02 -MIDN 9.06E-02 -HNRNPR 9.07E-02 -PSAP 9.07E-02 -COL4A2 9.08E-02 -TULP3 9.09E-02 -METAP2 9.09E-02 -MEIS2 9.10E-02 -PRKACA 9.11E-02 -NFIX 9.11E-02 -HNRNPUL2 9.12E-02 -ARRDC3 9.13E-02 -MARK4 9.14E-02 -SLC12A7 9.14E-02 -COPB2 9.15E-02 -OSR1 9.16E-02 -COL9A3 9.16E-02 -STAT5B 9.17E-02 -DHRS9 9.18E-02 -SYP 9.18E-02 -EEF1A1 9.19E-02 -KCNJ13 9.20E-02 -TRIM39 9.20E-02 -VKORC1L1 9.21E-02 -ZFX 9.22E-02 -CTDSPL2 9.22E-02 -HES1 9.23E-02 -SGCE 9.24E-02 -GUCY2D 9.25E-02 -LHX9 9.25E-02 -SLC7A4 9.26E-02 -ZC3H7A 9.27E-02 -GRIK2 9.27E-02 -GPC4 9.28E-02 -TPCN1 9.29E-02 -PTEN 9.29E-02 -ADRBK1 9.30E-02 -MLC1 9.31E-02 -COL15A1 9.31E-02 -SFRP1 9.32E-02 -SYT11 9.33E-02 -BRWD3 9.34E-02 -GRIA4 9.34E-02 -MTO1 9.35E-02 -FLCN 9.36E-02 -UBXN7 9.36E-02 -TYR 9.37E-02 -PLS1 9.38E-02 -PSMD13 9.38E-02 -DES 9.39E-02 -KCNA5 9.40E-02 -SMARCA2 9.40E-02 -TPCN2 9.41E-02 -CP 9.42E-02 -CBX4 9.42E-02 -GLDC 9.43E-02 -NGF 9.44E-02 -PTCHD1 9.45E-02 -HFE2 9.45E-02 -GNAQ 9.46E-02 -ZFAND3 9.47E-02 -NALCN 9.47E-02 -ATXN1 9.48E-02 -KLK10 9.49E-02 -ITGB5 9.49E-02 -ATAD3A 9.50E-02 -ABCA8 9.51E-02 -CRAMP1L 9.51E-02 -SLC45A2 9.52E-02 -IRF7 9.53E-02 -TPM3 9.53E-02 -KLHL36 9.54E-02 -NXPH4 9.55E-02 -ARSB 9.56E-02 -LAT 9.56E-02 -TPI1 9.57E-02 -HSPA8 9.58E-02 -CCNA2 9.58E-02 -FOXA1 9.59E-02 -FGF17 9.60E-02 -KIF5A 9.60E-02 -SETD8 9.61E-02 -GGCX 9.62E-02 -SERPINE2 9.62E-02 -NXN 9.63E-02 -RBL2 9.64E-02 -VIT 9.65E-02 -MYO1E 9.65E-02 -MPPED2 9.66E-02 -ATP8B2 9.67E-02 -VPS26B 9.67E-02 -BSDC1 9.68E-02 -KCNV2 9.69E-02 -COL9A2 9.69E-02 -PROC 9.70E-02 -YTHDF1 9.71E-02 -CPSF6 9.71E-02 -PTK7 9.72E-02 -C1orf226 9.73E-02 -EYA4 9.73E-02 -CLCN6 9.74E-02 -GLIS2 9.75E-02 -MAOB 9.76E-02 -ACACB 9.76E-02 -DLG3 9.77E-02 -NEFH 9.78E-02 -ABCC2 9.78E-02 -ZFR 9.79E-02 -SPTLC2 9.80E-02 -ELF3 9.80E-02 -CASC3 9.81E-02 -LMX1B 9.82E-02 -ZFPL1 9.82E-02 -GIPC1 9.83E-02 -WDR44 9.84E-02 -ALOX15B 9.84E-02 -ABCE1 9.85E-02 -GRIN1 9.86E-02 -EIF4B 9.87E-02 -AMT 9.87E-02 -CHRNA4 9.88E-02 -COL4A3 9.89E-02 -ASS1 9.89E-02 -CHRNA3 9.90E-02 -PHYHD1 9.91E-02 -SALL4 9.91E-02 -PCDH19 9.92E-02 -PCCB 9.93E-02 -POLA1 9.93E-02 -FAM155B 9.94E-02 -SBF2 9.95E-02 -OAT 9.96E-02 -EYA2 9.96E-02 -LTK 9.97E-02 -MANEAL 9.98E-02 -ATG5 9.98E-02 -SLC35E1 9.99E-02 -ATAD2 1.00E-01 -LDHA 1.00E-01 -CLMN 1.00E-01 -BMPR1B 1.00E-01 -LPHN3 1.00E-01 -UBP1 1.00E-01 -AKAP4 1.00E-01 -PPM1G 1.00E-01 -HCN3 1.01E-01 -FGFRL1 1.01E-01 -KCNJ5 1.01E-01 -SLITRK5 1.01E-01 -SLC26A7 1.01E-01 -PTPRA 1.01E-01 -KLF5 1.01E-01 -RPN1 1.01E-01 -NRN1 1.01E-01 -EEF2 1.01E-01 -RPGR 1.01E-01 -ZNF331 1.01E-01 -PRKCB 1.01E-01 -PRDM16 1.01E-01 -MTMR2 1.01E-01 -CENPB 1.02E-01 -PLAG1 1.02E-01 -PIN4 1.02E-01 -LIN9 1.02E-01 -FOXJ3 1.02E-01 -PI4K2A 1.02E-01 -MTSS1L 1.02E-01 -NDUFV1 1.02E-01 -CCNK 1.02E-01 -KRT37 1.02E-01 -TAOK1 1.02E-01 -CHRM4 1.02E-01 -ARMCX2 1.02E-01 -HOXC6 1.02E-01 -LMTK2 1.03E-01 -HAUS4 1.03E-01 -DHX9 1.03E-01 -ING3 1.03E-01 -FOXB1 1.03E-01 -CLDN15 1.03E-01 -CRB2 1.03E-01 -ATP5B 1.03E-01 -GP2 1.03E-01 -FBXO22 1.03E-01 -SPG7 1.03E-01 -DAZAP1 1.03E-01 -PAOX 1.03E-01 -TATDN3 1.03E-01 -SUV39H2 1.03E-01 -TULP1 1.04E-01 -SLC39A3 1.04E-01 -MGAM 1.04E-01 -SYAP1 1.04E-01 -THBS1 1.04E-01 -COL17A1 1.04E-01 -C1QTNF7 1.04E-01 -VASN 1.04E-01 -CBLB 1.04E-01 -AVPR2 1.04E-01 -ATP9A 1.04E-01 -AP2A2 1.04E-01 -MCRS1 1.04E-01 -ADCY2 1.04E-01 -WAPAL 1.05E-01 -S1PR5 1.05E-01 -PITX1 1.05E-01 -NFE2L1 1.05E-01 -RIMS4 1.05E-01 -GNA15 1.05E-01 -ZNF395 1.05E-01 -SNCA 1.05E-01 -KLK7 1.05E-01 -ATP1A2 1.05E-01 -KIAA1958 1.05E-01 -ST8SIA3 1.05E-01 -KIAA1468 1.05E-01 -RNF14 1.05E-01 -PEX26 1.05E-01 -ACTC1 1.06E-01 -RBBP5 1.06E-01 -ISOC2 1.06E-01 -LRP5L 1.06E-01 -PSMD6 1.06E-01 -YOD1 1.06E-01 -MSR1 1.06E-01 -XKR6 1.06E-01 -RAB12 1.06E-01 -XPO6 1.06E-01 -ABAT 1.06E-01 -YWHAH 1.06E-01 -PPT2 1.06E-01 -NAB1 1.06E-01 -IGF1R 1.07E-01 -REEP1 1.07E-01 -ACAD10 1.07E-01 -GOT2 1.07E-01 -FZD7 1.07E-01 -GRIA3 1.07E-01 -GCM1 1.07E-01 -F10 1.07E-01 -CCND2 1.07E-01 -G3BP2 1.07E-01 -GJB3 1.07E-01 -GPRC5B 1.07E-01 -MED30 1.07E-01 -FRMD7 1.07E-01 -PQLC1 1.07E-01 -GLYR1 1.08E-01 -ABCC12 1.08E-01 -THBS2 1.08E-01 -TSC22D2 1.08E-01 -SYNJ2 1.08E-01 -KIRREL 1.08E-01 -GJA1 1.08E-01 -AGPAT2 1.08E-01 -PAPD5 1.08E-01 -SRP54 1.08E-01 -TSC22D1 1.08E-01 -GRID1 1.08E-01 -TRIP13 1.08E-01 -WDR82 1.08E-01 -TRPC7 1.09E-01 -FLT3LG 1.09E-01 -ANK1 1.09E-01 -SERPINA10 1.09E-01 -ZCCHC11 1.09E-01 -KRT9 1.09E-01 -SLC5A5 1.09E-01 -COX10 1.09E-01 -STMN3 1.09E-01 -NPDC1 1.09E-01 -SESN3 1.09E-01 -RBM47 1.09E-01 -LCORL 1.09E-01 -DLGAP2 1.09E-01 -TBX4 1.09E-01 -UMOD 1.10E-01 -TULP4 1.10E-01 -DPYD 1.10E-01 -KLK8 1.10E-01 -CNTFR 1.10E-01 -MYH7B 1.10E-01 -PLAT 1.10E-01 -NFS1 1.10E-01 -ORAI2 1.10E-01 -PSMA6 1.10E-01 -KRT6B 1.10E-01 -YWHAE 1.10E-01 -POU6F2 1.10E-01 -MAFK 1.10E-01 -AMOT 1.11E-01 -POU4F3 1.11E-01 -HMGA2 1.11E-01 -USP34 1.11E-01 -LRRN2 1.11E-01 -AQP1 1.11E-01 -CAPN10 1.11E-01 -WDR11 1.11E-01 -SAP30L 1.11E-01 -HCN1 1.11E-01 -SEPT6 1.11E-01 -PAQR9 1.11E-01 -SERPINA9 1.11E-01 -GPR107 1.11E-01 -HNRNPH2 1.11E-01 -EIF5 1.12E-01 -EPHB2 1.12E-01 -HOXB3 1.12E-01 -RBBP7 1.12E-01 -MTMR12 1.12E-01 -TRIM27 1.12E-01 -MYH3 1.12E-01 -SNRNP200 1.12E-01 -BTG3 1.12E-01 -SSBP2 1.12E-01 -FBXO11 1.12E-01 -CDC73 1.12E-01 -STK11 1.12E-01 -IL2RB 1.12E-01 -SLC2A14 1.13E-01 -CASC4 1.13E-01 -DNM2 1.13E-01 -RAP2B 1.13E-01 -MYADM 1.13E-01 -NID2 1.13E-01 -ATHL1 1.13E-01 -CADM1 1.13E-01 -CROT 1.13E-01 -ATP2C2 1.13E-01 -CBLN1 1.13E-01 -GDF2 1.13E-01 -TPST2 1.13E-01 -TCTN2 1.13E-01 -NOX5 1.13E-01 -PCF11 1.14E-01 -CRX 1.14E-01 -CATSPER1 1.14E-01 -PPP1R10 1.14E-01 -PHLDA3 1.14E-01 -SLC7A7 1.14E-01 -MFAP1 1.14E-01 -DCT 1.14E-01 -RPE65 1.14E-01 -PEX6 1.14E-01 -ADAD2 1.14E-01 -SLC4A8 1.14E-01 -MYO1F 1.14E-01 -FRMD4B 1.14E-01 -ZBTB16 1.15E-01 -PSMC3 1.15E-01 -CLDN11 1.15E-01 -SARDH 1.15E-01 -ISYNA1 1.15E-01 -TPP1 1.15E-01 -HEXIM1 1.15E-01 -FAM105B 1.15E-01 -SCN7A 1.15E-01 -TUBB 1.15E-01 -ABCD3 1.15E-01 -ARMCX1 1.15E-01 -HSF2 1.15E-01 -ING4 1.15E-01 -ANKH 1.15E-01 -TMEM127 1.16E-01 -GATAD1 1.16E-01 -IKZF3 1.16E-01 -CSNK2B 1.16E-01 -CD74 1.16E-01 -SMAD4 1.16E-01 -NF1 1.16E-01 -PCCA 1.16E-01 -GBE1 1.16E-01 -SPTAN1 1.16E-01 -MED19 1.16E-01 -RBL1 1.16E-01 -SOX13 1.16E-01 -PRCC 1.16E-01 -UBQLN1 1.17E-01 -LIMK2 1.17E-01 -MSH3 1.17E-01 -TEX264 1.17E-01 -GPR101 1.17E-01 -RGS19 1.17E-01 -OFD1 1.17E-01 -TOMM22 1.17E-01 -EIF2S3 1.17E-01 -KIAA0226 1.17E-01 -FOXP2 1.17E-01 -EXOC8 1.17E-01 -CHSY1 1.17E-01 -DEDD2 1.17E-01 -DLGAP4 1.17E-01 -FOXO4 1.18E-01 -LDHD 1.18E-01 -TGFB3 1.18E-01 -TPTE2 1.18E-01 -MYO18A 1.18E-01 -TCF7L1 1.18E-01 -EIF6 1.18E-01 -TGM1 1.18E-01 -PSMC6 1.18E-01 -SNX27 1.18E-01 -NASP 1.18E-01 -EPHA4 1.18E-01 -ABCB8 1.18E-01 -MON1A 1.18E-01 -LZTS1 1.18E-01 -RGAG1 1.19E-01 -YLPM1 1.19E-01 -SLC5A10 1.19E-01 -MAGEB4 1.19E-01 -SERPINA7 1.19E-01 -PHYH 1.19E-01 -MTMR14 1.19E-01 -IL2RG 1.19E-01 -KIAA1045 1.19E-01 -TRA2B 1.19E-01 -IL4I1 1.19E-01 -MBTD1 1.19E-01 -E2F2 1.19E-01 -NPAS2 1.19E-01 -KCNH8 1.20E-01 -KRT16 1.20E-01 -RANBP10 1.20E-01 -SERPINH1 1.20E-01 -NUP54 1.20E-01 -NGFR 1.20E-01 -CNOT4 1.20E-01 -CLCNKB 1.20E-01 -SH3BP5 1.20E-01 -MAST1 1.20E-01 -FZD8 1.20E-01 -SEC23B 1.20E-01 -HOXB1 1.20E-01 -ST6GAL1 1.20E-01 -CYLC1 1.20E-01 -GK 1.21E-01 -PAPOLA 1.21E-01 -PDZD4 1.21E-01 -TAF12 1.21E-01 -APBB1 1.21E-01 -LPCAT4 1.21E-01 -RBM6 1.21E-01 -CHD8 1.21E-01 -CACNB1 1.21E-01 -HNRNPA2B1 1.21E-01 -AEBP2 1.21E-01 -MAK16 1.21E-01 -RCC1 1.21E-01 -NR1D2 1.21E-01 -JAKMIP2 1.22E-01 -POLR3H 1.22E-01 -SEPN1 1.22E-01 -EIF2B3 1.22E-01 -RP2 1.22E-01 -DLK1 1.22E-01 -ETFB 1.22E-01 -SP3 1.22E-01 -MATN4 1.22E-01 -ELAVL4 1.22E-01 -ZMYND11 1.22E-01 -PISD 1.22E-01 -SFTPC 1.22E-01 -KATNAL1 1.22E-01 -MGAT2 1.22E-01 -ATP1A4 1.23E-01 -ZNF24 1.23E-01 -PDGFRB 1.23E-01 -FOXN2 1.23E-01 -MYH4 1.23E-01 -TAB2 1.23E-01 -TBCEL 1.23E-01 -ITPKB 1.23E-01 -CFL1 1.23E-01 -ATP4A 1.23E-01 -CSHL1 1.23E-01 -BMP7 1.23E-01 -SLC32A1 1.23E-01 -HABP2 1.23E-01 -FBXO5 1.24E-01 -AIRE 1.24E-01 -DLG5 1.24E-01 -PDHB 1.24E-01 -ATP13A3 1.24E-01 -ADAR 1.24E-01 -EBF1 1.24E-01 -ARSE 1.24E-01 -GABRB3 1.24E-01 -TMEM100 1.24E-01 -CCR1 1.24E-01 -CALM2 1.24E-01 -NPNT 1.24E-01 -AGPS 1.24E-01 -C18orf25 1.24E-01 -CDC14B 1.25E-01 -RBM15B 1.25E-01 -INTS10 1.25E-01 -CDK6 1.25E-01 -PDGFRA 1.25E-01 -SLC5A6 1.25E-01 -PRSS1 1.25E-01 -PFKFB3 1.25E-01 -HPS4 1.25E-01 -F2 1.25E-01 -MAGEA11 1.25E-01 -EFEMP2 1.25E-01 -ARCN1 1.25E-01 -CD320 1.25E-01 -CHAF1A 1.26E-01 -SURF4 1.26E-01 -AMPD1 1.26E-01 -MYH1 1.26E-01 -E2F4 1.26E-01 -CAPN9 1.26E-01 -BSN 1.26E-01 -SOD1 1.26E-01 -SUPT16H 1.26E-01 -MAPK8 1.26E-01 -FZD1 1.26E-01 -FGG 1.26E-01 -RNF182 1.26E-01 -NR1H4 1.26E-01 -BTD 1.26E-01 -SLC45A4 1.27E-01 -CLIP2 1.27E-01 -TMOD1 1.27E-01 -SHOX2 1.27E-01 -ITGB3 1.27E-01 -LAX1 1.27E-01 -PPP4C 1.27E-01 -NDUFS7 1.27E-01 -NVL 1.27E-01 -MRPL43 1.27E-01 -LCAT 1.27E-01 -MASP1 1.27E-01 -BAG3 1.27E-01 -PTPN6 1.27E-01 -KIAA0907 1.28E-01 -IGF1 1.28E-01 -POGZ 1.28E-01 -ADAD1 1.28E-01 -TPSG1 1.28E-01 -SLC25A19 1.28E-01 -AQP6 1.28E-01 -HPRT1 1.28E-01 -DSN1 1.28E-01 -TNNI2 1.28E-01 -RAP1GAP2 1.28E-01 -LCK 1.28E-01 -GDA 1.28E-01 -CDKL5 1.28E-01 -RRAGB 1.28E-01 -PPP5C 1.29E-01 -SLC25A11 1.29E-01 -ATP13A1 1.29E-01 -ACTA2 1.29E-01 -DNM1L 1.29E-01 -MBNL3 1.29E-01 -PRIMA1 1.29E-01 -XBP1 1.29E-01 -REEP2 1.29E-01 -TET3 1.29E-01 -SLC3A1 1.29E-01 -HSD3B2 1.29E-01 -PARK7 1.29E-01 -HIST1H3C 1.29E-01 -TMEM57 1.30E-01 -ARL8A 1.30E-01 -HSD11B2 1.30E-01 -PRKCG 1.30E-01 -TBX20 1.30E-01 -KLK12 1.30E-01 -SSBP4 1.30E-01 -PAIP1 1.30E-01 -SLIT1 1.30E-01 -DGKG 1.30E-01 -SCARA3 1.30E-01 -METRNL 1.30E-01 -SYNGR1 1.30E-01 -CD247 1.30E-01 -TPH2 1.30E-01 -PHRF1 1.31E-01 -UBQLN2 1.31E-01 -HGF 1.31E-01 -GABRA5 1.31E-01 -ZRANB1 1.31E-01 -MFSD2A 1.31E-01 -HS3ST5 1.31E-01 -GRIPAP1 1.31E-01 -KCNS3 1.31E-01 -CPT2 1.31E-01 -SDHD 1.31E-01 -WASL 1.31E-01 -ABCA10 1.31E-01 -SPTBN1 1.31E-01 -CDC5L 1.32E-01 -CBLN4 1.32E-01 -TGFBI 1.32E-01 -RBMX 1.32E-01 -FGD1 1.32E-01 -PDS5B 1.32E-01 -SLCO3A1 1.32E-01 -PANK2 1.32E-01 -FBXL20 1.32E-01 -TNNT1 1.32E-01 -KCNG1 1.32E-01 -SPATS2 1.32E-01 -SIPA1L3 1.32E-01 -COPS7A 1.32E-01 -COL16A1 1.32E-01 -ALAD 1.33E-01 -C2CD2L 1.33E-01 -SEMA6A 1.33E-01 -HMGCS1 1.33E-01 -RSBN1L 1.33E-01 -XPO7 1.33E-01 -NXPH1 1.33E-01 -ALDOB 1.33E-01 -CHST3 1.33E-01 -HN1 1.33E-01 -ATP5A1 1.33E-01 -RBM15 1.33E-01 -LTA 1.33E-01 -PCYT2 1.33E-01 -BDH1 1.34E-01 -DAB2 1.34E-01 -ATXN7L3 1.34E-01 -SIPA1L2 1.34E-01 -KLK6 1.34E-01 -RASA1 1.34E-01 -ACAA1 1.34E-01 -TMPRSS6 1.34E-01 -CDK12 1.34E-01 -NOX1 1.34E-01 -ROS1 1.34E-01 -ZNRF3 1.34E-01 -CARHSP1 1.34E-01 -ADCY1 1.34E-01 -PDIK1L 1.34E-01 -SCML2 1.35E-01 -ACTL9 1.35E-01 -PAPOLG 1.35E-01 -DUOX2 1.35E-01 -TSHZ2 1.35E-01 -CCDC149 1.35E-01 -ADAMTS2 1.35E-01 -EIF4G1 1.35E-01 -TSHZ3 1.35E-01 -SLC17A7 1.35E-01 -GPRC6A 1.35E-01 -SLC7A8 1.35E-01 -NDE1 1.35E-01 -LONP1 1.35E-01 -GLIS1 1.36E-01 -TFDP1 1.36E-01 -TM9SF4 1.36E-01 -STRN3 1.36E-01 -IRF4 1.36E-01 -ATP11A 1.36E-01 -NIP7 1.36E-01 -HUWE1 1.36E-01 -RILPL2 1.36E-01 -NDUFAB1 1.36E-01 -ARSI 1.36E-01 -C10orf88 1.36E-01 -RNF185 1.36E-01 -OGDH 1.36E-01 -ZNF512B 1.36E-01 -S1PR2 1.37E-01 -SGSH 1.37E-01 -FOXS1 1.37E-01 -PSMB1 1.37E-01 -H2AFY 1.37E-01 -FBL 1.37E-01 -MEOX1 1.37E-01 -FOXH1 1.37E-01 -IL10RA 1.37E-01 -TGM6 1.37E-01 -LIMA1 1.37E-01 -COX5A 1.37E-01 -UMODL1 1.37E-01 -NIT1 1.37E-01 -CAPN6 1.38E-01 -TMEM51 1.38E-01 -EDC3 1.38E-01 -LRRTM1 1.38E-01 -GJA8 1.38E-01 -PLLP 1.38E-01 -ACP5 1.38E-01 -HBD 1.38E-01 -TLX1 1.38E-01 -ZNF704 1.38E-01 -GABBR2 1.38E-01 -ACVR1 1.38E-01 -NOTCH4 1.38E-01 -HOXA2 1.38E-01 -KIAA1191 1.38E-01 -TK2 1.39E-01 -MLLT6 1.39E-01 -SYT7 1.39E-01 -UBE2Q1 1.39E-01 -C7orf26 1.39E-01 -TMPRSS4 1.39E-01 -SLC39A10 1.39E-01 -AQP4 1.39E-01 -EHD3 1.39E-01 -DCAF5 1.39E-01 -ITPR2 1.39E-01 -CORO1A 1.39E-01 -AHCYL1 1.39E-01 -MYH8 1.39E-01 -RIC8B 1.40E-01 -CHERP 1.40E-01 -RXRB 1.40E-01 -LYPD2 1.40E-01 -AEBP1 1.40E-01 -GAMT 1.40E-01 -UCKL1 1.40E-01 -IL7 1.40E-01 -ATP1B1 1.40E-01 -KLK15 1.40E-01 -ZNF460 1.40E-01 -CLIC2 1.40E-01 -SLC5A2 1.40E-01 -RAD51 1.40E-01 -SDHB 1.40E-01 -SLC20A1 1.41E-01 -ELL2 1.41E-01 -MOSPD3 1.41E-01 -PRR19 1.41E-01 -FNBP4 1.41E-01 -TUBAL3 1.41E-01 -DAGLA 1.41E-01 -UTP14A 1.41E-01 -NLRP4 1.41E-01 -C5orf30 1.41E-01 -PSMC5 1.41E-01 -TNFAIP3 1.41E-01 -PSMA2 1.41E-01 -GJB4 1.41E-01 -TMEM190 1.42E-01 -ZBED1 1.42E-01 -KRT31 1.42E-01 -PHF6 1.42E-01 -AMELX 1.42E-01 -C20orf195 1.42E-01 -AP2A1 1.42E-01 -SRP68 1.42E-01 -HNRNPAB 1.42E-01 -PHTF2 1.42E-01 -ATP10A 1.42E-01 -CD2 1.42E-01 -TESK1 1.42E-01 -CLN8 1.42E-01 -KCNA7 1.42E-01 -SAMD4A 1.43E-01 -MARCH5 1.43E-01 -ITGB7 1.43E-01 -ENOX2 1.43E-01 -PLA2G15 1.43E-01 -MAT2A 1.43E-01 -LIPT1 1.43E-01 -VAX2 1.43E-01 -BCL9L 1.43E-01 -CCT8 1.43E-01 -CAPN2 1.43E-01 -TBX15 1.43E-01 -MYO5A 1.43E-01 -CCNYL1 1.43E-01 -SPTB 1.44E-01 -XPR1 1.44E-01 -ASPA 1.44E-01 -HGFAC 1.44E-01 -MYO1G 1.44E-01 -BCR 1.44E-01 -MCCC1 1.44E-01 -C2orf69 1.44E-01 -LAPTM5 1.44E-01 -CHRNB4 1.44E-01 -ING5 1.44E-01 -GRIK5 1.44E-01 -GPR85 1.44E-01 -CDKN2A 1.44E-01 -MOCS1 1.44E-01 -SARS 1.45E-01 -CLDN16 1.45E-01 -YWHAQ 1.45E-01 -RPGRIP1L 1.45E-01 -RBM33 1.45E-01 -WIPF1 1.45E-01 -CETN1 1.45E-01 -ASRGL1 1.45E-01 -SLC1A2 1.45E-01 -KBTBD2 1.45E-01 -DLG2 1.45E-01 -RNF166 1.45E-01 -PIGU 1.45E-01 -PURG 1.45E-01 -PPP1R9A 1.46E-01 -ATP6V1B2 1.46E-01 -ZCCHC14 1.46E-01 -BEND4 1.46E-01 -MAP4 1.46E-01 -ABCC5 1.46E-01 -PTCHD2 1.46E-01 -CPOX 1.46E-01 -LPCAT1 1.46E-01 -FLRT3 1.46E-01 -SGPP1 1.46E-01 -CLDN9 1.46E-01 -RUNX1 1.46E-01 -ALOXE3 1.46E-01 -TINF2 1.46E-01 -MLH3 1.47E-01 -EDNRA 1.47E-01 -DHRS4L2 1.47E-01 -ODC1 1.47E-01 -SYN3 1.47E-01 -GTF2A1 1.47E-01 -IRF9 1.47E-01 -RRM2B 1.47E-01 -SNX8 1.47E-01 -ERBB4 1.47E-01 -KRT74 1.47E-01 -KCNG4 1.47E-01 -EFNA1 1.47E-01 -STOX2 1.47E-01 -MST1 1.48E-01 -PPP4R4 1.48E-01 -RSPRY1 1.48E-01 -PTOV1 1.48E-01 -RNF41 1.48E-01 -CEPT1 1.48E-01 -COL19A1 1.48E-01 -SPINT1 1.48E-01 -DFFA 1.48E-01 -TMEM87A 1.48E-01 -UCN2 1.48E-01 -PPP1R14D 1.48E-01 -DDAH1 1.48E-01 -MYOG 1.48E-01 -CD40 1.48E-01 -ERBB2 1.49E-01 -CYGB 1.49E-01 -ARHGAP36 1.49E-01 -P2RY10 1.49E-01 -RRM1 1.49E-01 -NLGN4X 1.49E-01 -COMMD1 1.49E-01 -GNL1 1.49E-01 -FNDC3B 1.49E-01 -PCDH17 1.49E-01 -ABCA9 1.49E-01 -SIVA1 1.49E-01 -IL27 1.49E-01 -NFKBIB 1.49E-01 -HPCA 1.50E-01 -CHST6 1.50E-01 -CSF1R 1.50E-01 -ALX3 1.50E-01 -BCMO1 1.50E-01 -RNF10 1.50E-01 -FZD9 1.50E-01 -DNMT3A 1.50E-01 -RMND5A 1.50E-01 -PTPRO 1.50E-01 -FUT2 1.50E-01 -TCF25 1.50E-01 -SLIT3 1.50E-01 -AHSA1 1.50E-01 -ADRB3 1.50E-01 -STAT1 1.51E-01 -SLC4A11 1.51E-01 -VAX1 1.51E-01 -HDAC4 1.51E-01 -PHGDH 1.51E-01 -GLTPD1 1.51E-01 -CCDC106 1.51E-01 -CHST4 1.51E-01 -SMAD9 1.51E-01 -KIRREL3 1.51E-01 -STEAP3 1.51E-01 -GSTK1 1.51E-01 -PCGF1 1.51E-01 -ZNF654 1.51E-01 -PTP4A2 1.51E-01 -IL12A 1.52E-01 -ABCD4 1.52E-01 -PRSS3 1.52E-01 -TAF1 1.52E-01 -SMPD3 1.52E-01 -BATF 1.52E-01 -PDLIM7 1.52E-01 -POMT2 1.52E-01 -GPR50 1.52E-01 -UBE2E2 1.52E-01 -KCNN4 1.52E-01 -GPR37 1.52E-01 -P2RY8 1.52E-01 -CCNJ 1.52E-01 -HMGB1 1.53E-01 -CNGA4 1.53E-01 -NPHP3 1.53E-01 -MIB2 1.53E-01 -CATSPER4 1.53E-01 -CLIC5 1.53E-01 -USP22 1.53E-01 -ADO 1.53E-01 -CXorf21 1.53E-01 -HIST1H1B 1.53E-01 -GALK2 1.53E-01 -FGFR1OP2 1.53E-01 -ZMYND19 1.53E-01 -MATN2 1.53E-01 -PTCHD3 1.53E-01 -RUVBL2 1.54E-01 -TMPRSS3 1.54E-01 -SNCG 1.54E-01 -IVD 1.54E-01 -NUDT16L1 1.54E-01 -ITPK1 1.54E-01 -MEIS3 1.54E-01 -ZMIZ1 1.54E-01 -GUCA2B 1.54E-01 -KCNJ9 1.54E-01 -ARSF 1.54E-01 -MEST 1.54E-01 -PHF19 1.54E-01 -STAT2 1.54E-01 -COPS3 1.55E-01 -C11orf58 1.55E-01 -COL18A1 1.55E-01 -ACADM 1.55E-01 -TTF2 1.55E-01 -ATF7IP 1.55E-01 -ALX4 1.55E-01 -BCL6 1.55E-01 -ST8SIA2 1.55E-01 -TUBA1B 1.55E-01 -UCK2 1.55E-01 -COL6A6 1.55E-01 -KPNA6 1.55E-01 -LHX4 1.55E-01 -CNIH2 1.55E-01 -HRCT1 1.56E-01 -TASP1 1.56E-01 -PPP3CB 1.56E-01 -IPO5 1.56E-01 -ARMCX5 1.56E-01 -TLK2 1.56E-01 -FMNL2 1.56E-01 -MAX 1.56E-01 -SCUBE2 1.56E-01 -PNKD 1.56E-01 -AP2B1 1.56E-01 -ANTXR1 1.56E-01 -RAG1 1.56E-01 -CHST15 1.56E-01 -PSMD12 1.57E-01 -GSK3B 1.57E-01 -CFI 1.57E-01 -SLC26A3 1.57E-01 -CELSR1 1.57E-01 -BBS9 1.57E-01 -ANAPC2 1.57E-01 -ELL 1.57E-01 -EIF4EBP2 1.57E-01 -BRI3BP 1.57E-01 -NUDT3 1.57E-01 -GGNBP2 1.57E-01 -BRMS1 1.57E-01 -MPZ 1.57E-01 -IGFN1 1.57E-01 -EDAR 1.58E-01 -ZNF146 1.58E-01 -BCAR1 1.58E-01 -CBFB 1.58E-01 -SEC24C 1.58E-01 -ANKRD46 1.58E-01 -PPFIA2 1.58E-01 -ALDH3B2 1.58E-01 -ATG3 1.58E-01 -GDF5 1.58E-01 -CNGB1 1.58E-01 -PCSK2 1.58E-01 -AKAP14 1.58E-01 -SEMA3F 1.58E-01 -SERPINB5 1.59E-01 -KIAA0196 1.59E-01 -KLHL22 1.59E-01 -ALG8 1.59E-01 -JAK3 1.59E-01 -FLYWCH1 1.59E-01 -BARHL2 1.59E-01 -NCSTN 1.59E-01 -RBP4 1.59E-01 -NAA30 1.59E-01 -MBNL1 1.59E-01 -IQSEC1 1.59E-01 -PBX2 1.59E-01 -PRMT5 1.59E-01 -NAGLU 1.59E-01 -AMIGO2 1.60E-01 -HAGH 1.60E-01 -SLC4A1 1.60E-01 -COL28A1 1.60E-01 -TMEM89 1.60E-01 -HNRNPD 1.60E-01 -SERTAD4 1.60E-01 -CHRNE 1.60E-01 -BTBD2 1.60E-01 -BMPR1A 1.60E-01 -KCNK5 1.60E-01 -PLXND1 1.60E-01 -ZNF512 1.60E-01 -RAD54L 1.60E-01 -ATP6V0A2 1.61E-01 -FRMD6 1.61E-01 -KLKB1 1.61E-01 -ZNF629 1.61E-01 -FAM193A 1.61E-01 -FAM180A 1.61E-01 -SLC25A25 1.61E-01 -GBA2 1.61E-01 -KRT19 1.61E-01 -LRCH1 1.61E-01 -EEPD1 1.61E-01 -SLC35F3 1.61E-01 -CECR1 1.61E-01 -ALX1 1.61E-01 -UBFD1 1.61E-01 -HOXB9 1.62E-01 -FBXO21 1.62E-01 -PEX2 1.62E-01 -TRPV2 1.62E-01 -ABRA 1.62E-01 -ASTN1 1.62E-01 -TSPAN14 1.62E-01 -NDUFC1 1.62E-01 -KRT34 1.62E-01 -HOXC4 1.62E-01 -SCARA5 1.62E-01 -HEPACAM 1.62E-01 -TRIM45 1.62E-01 -ANKRD44 1.62E-01 -PPTC7 1.63E-01 -SEMA4C 1.63E-01 -CUTA 1.63E-01 -IL13RA1 1.63E-01 -IRS4 1.63E-01 -HOXD13 1.63E-01 -CHMP7 1.63E-01 -UBE2O 1.63E-01 -PRKAG3 1.63E-01 -CHRNA1 1.63E-01 -FBXO46 1.63E-01 -PITPNM2 1.63E-01 -SNRPN 1.63E-01 -HRH3 1.63E-01 -GJB2 1.63E-01 -IRX6 1.64E-01 -NANOS2 1.64E-01 -VSX2 1.64E-01 -NTN1 1.64E-01 -RRM2 1.64E-01 -CATSPER2 1.64E-01 -ACTRT2 1.64E-01 -POLR2L 1.64E-01 -COL10A1 1.64E-01 -C1orf52 1.64E-01 -C7orf60 1.64E-01 -COL25A1 1.64E-01 -EIF3G 1.64E-01 -KRT3 1.64E-01 -ABCB6 1.65E-01 -PGK2 1.65E-01 -WWC3 1.65E-01 -TRAF2 1.65E-01 -GAK 1.65E-01 -CTSC 1.65E-01 -GRPEL1 1.65E-01 -NLGN3 1.65E-01 -ZNF236 1.65E-01 -UBTD2 1.65E-01 -SLITRK3 1.65E-01 -TALDO1 1.65E-01 -CAMK2A 1.65E-01 -CBX8 1.65E-01 -KIF13B 1.65E-01 -BARHL1 1.66E-01 -TMPRSS2 1.66E-01 -SLC25A28 1.66E-01 -ZNF266 1.66E-01 -CFLAR 1.66E-01 -SLC22A12 1.66E-01 -IL5RA 1.66E-01 -TBCCD1 1.66E-01 -BBS1 1.66E-01 -ICA1 1.66E-01 -PTPN14 1.66E-01 -HEG1 1.66E-01 -UBE2E1 1.66E-01 -TERF1 1.66E-01 -DCUN1D3 1.67E-01 -RNF4 1.67E-01 -ILKAP 1.67E-01 -FRMD8 1.67E-01 -HSD3B7 1.67E-01 -COX15 1.67E-01 -YKT6 1.67E-01 -FAM20C 1.67E-01 -DKK2 1.67E-01 -DOLPP1 1.67E-01 -SPSB1 1.67E-01 -FYN 1.67E-01 -PHF21B 1.67E-01 -ATAD3B 1.67E-01 -GABRA2 1.67E-01 -JAK1 1.68E-01 -SERPIND1 1.68E-01 -ACAD9 1.68E-01 -UPF2 1.68E-01 -BNC2 1.68E-01 -KRT8 1.68E-01 -ZFYVE28 1.68E-01 -PEX5L 1.68E-01 -HSPB7 1.68E-01 -GOLIM4 1.68E-01 -KCNA10 1.68E-01 -IL21R 1.68E-01 -HOMER3 1.68E-01 -SLA 1.68E-01 -SYVN1 1.69E-01 -HSF5 1.69E-01 -ACTL7B 1.69E-01 -MSRA 1.69E-01 -SLC9A3 1.69E-01 -SMNDC1 1.69E-01 -IRF2 1.69E-01 -GRIN2B 1.69E-01 -CBX1 1.69E-01 -FAM46C 1.69E-01 -TMEM64 1.69E-01 -AXIN1 1.69E-01 -TLCD1 1.69E-01 -HS3ST2 1.69E-01 -FTH1 1.69E-01 -BCS1L 1.70E-01 -TSPAN3 1.70E-01 -PRPF31 1.70E-01 -HOXC8 1.70E-01 -HEXA 1.70E-01 -PTK2B 1.70E-01 -C20orf24 1.70E-01 -KRT75 1.70E-01 -RASGRF1 1.70E-01 -HOOK3 1.70E-01 -SERPINE1 1.70E-01 -PRSS21 1.70E-01 -POGK 1.70E-01 -TMEM55B 1.70E-01 -TRIOBP 1.71E-01 -NEUROD1 1.71E-01 -CSTF1 1.71E-01 -STK40 1.71E-01 -SERPINB10 1.71E-01 -FGF18 1.71E-01 -KRT76 1.71E-01 -AIP 1.71E-01 -PRPH2 1.71E-01 -C20orf27 1.71E-01 -CLN6 1.71E-01 -FAM50A 1.71E-01 -ARSG 1.71E-01 -USP47 1.71E-01 -MTMR7 1.71E-01 -FGD5 1.72E-01 -SLC25A4 1.72E-01 -HMGB3 1.72E-01 -ARAF 1.72E-01 -AQP3 1.72E-01 -COL14A1 1.72E-01 -CYR61 1.72E-01 -USP11 1.72E-01 -FAM57A 1.72E-01 -RGS7BP 1.72E-01 -ADA 1.72E-01 -TKT 1.72E-01 -AZI2 1.72E-01 -UBE2Z 1.72E-01 -CBLC 1.73E-01 -KRT78 1.73E-01 -MTMR8 1.73E-01 -TOPORS 1.73E-01 -SMAD2 1.73E-01 -RAC2 1.73E-01 -ALPPL2 1.73E-01 -GARNL3 1.73E-01 -PAK3 1.73E-01 -TYMS 1.73E-01 -UROS 1.73E-01 -MSH4 1.73E-01 -SLC16A1 1.73E-01 -RAB11A 1.73E-01 -SERPINA6 1.73E-01 -PAX4 1.74E-01 -IRF8 1.74E-01 -UBQLN4 1.74E-01 -PAG1 1.74E-01 -RNF170 1.74E-01 -CCR7 1.74E-01 -MTBP 1.74E-01 -SRRM2 1.74E-01 -MAGEH1 1.74E-01 -TNFSF12 1.74E-01 -COL24A1 1.74E-01 -TREX1 1.74E-01 -ALPP 1.74E-01 -PARP6 1.74E-01 -RPH3AL 1.75E-01 -RELN 1.75E-01 -SLC38A1 1.75E-01 -FHIT 1.75E-01 -COMP 1.75E-01 -GPM6B 1.75E-01 -INTS3 1.75E-01 -PPP2R5B 1.75E-01 -PCDHAC2 1.75E-01 -RRAGC 1.75E-01 -PFN1 1.75E-01 -TMEM37 1.75E-01 -FGF23 1.75E-01 -MTMR1 1.75E-01 -SMC2 1.75E-01 -PYGO2 1.76E-01 -PCDHGC4 1.76E-01 -KRT40 1.76E-01 -MRFAP1 1.76E-01 -SLC10A7 1.76E-01 -KDM5B 1.76E-01 -DAZL 1.76E-01 -ITPKC 1.76E-01 -HCK 1.76E-01 -YWHAB 1.76E-01 -PPP2R5A 1.76E-01 -CDYL2 1.76E-01 -MAP3K10 1.76E-01 -C6orf62 1.76E-01 -TMEM184B 1.77E-01 -CREBZF 1.77E-01 -ETV6 1.77E-01 -TAOK3 1.77E-01 -HSD3B1 1.77E-01 -RAP2C 1.77E-01 -RFX2 1.77E-01 -RSBN1 1.77E-01 -NUP107 1.77E-01 -BRPF3 1.77E-01 -MEOX2 1.77E-01 -PAF1 1.77E-01 -KIAA1841 1.77E-01 -GJA5 1.77E-01 -PGAP3 1.77E-01 -CCDC6 1.78E-01 -ALG3 1.78E-01 -LSM10 1.78E-01 -AAAS 1.78E-01 -ITGAV 1.78E-01 -TTC7B 1.78E-01 -DHODH 1.78E-01 -GMFB 1.78E-01 -LTBR 1.78E-01 -S100PBP 1.78E-01 -ASB9 1.78E-01 -ZDHHC15 1.78E-01 -CLDN7 1.78E-01 -INPP5A 1.78E-01 -KRT32 1.79E-01 -MTMR11 1.79E-01 -PACS1 1.79E-01 -GJD2 1.79E-01 -EXTL1 1.79E-01 -KIF3A 1.79E-01 -LONRF2 1.79E-01 -ISL1 1.79E-01 -SHROOM4 1.79E-01 -SMEK1 1.79E-01 -MYO6 1.79E-01 -CCDC92 1.79E-01 -HOXA3 1.79E-01 -SDR42E1 1.79E-01 -PLAC1 1.79E-01 -NFKB2 1.80E-01 -LRFN5 1.80E-01 -CTLA4 1.80E-01 -TAF5 1.80E-01 -THBS4 1.80E-01 -UROD 1.80E-01 -SNW1 1.80E-01 -CDK2AP1 1.80E-01 -TADA3 1.80E-01 -DTNA 1.80E-01 -FRS2 1.80E-01 -ENAH 1.80E-01 -POLR3K 1.80E-01 -SCP2 1.80E-01 -TADA2B 1.81E-01 -LIM2 1.81E-01 -SLC7A10 1.81E-01 -KRT77 1.81E-01 -CBX7 1.81E-01 -TUBA8 1.81E-01 -LARP6 1.81E-01 -GLB1L 1.81E-01 -KRT15 1.81E-01 -SPATA5 1.81E-01 -POU2F1 1.81E-01 -STC1 1.81E-01 -ABI2 1.81E-01 -FAM199X 1.81E-01 -LMNB1 1.81E-01 -SNED1 1.82E-01 -SCN3B 1.82E-01 -PAX1 1.82E-01 -RFK 1.82E-01 -UBIAD1 1.82E-01 -ADCY6 1.82E-01 -C18orf8 1.82E-01 -CSNK2A1 1.82E-01 -STAT5A 1.82E-01 -NOX3 1.82E-01 -CHST2 1.82E-01 -NCOA1 1.82E-01 -DCLK2 1.82E-01 -RASL11B 1.82E-01 -RNF17 1.83E-01 -UNC13B 1.83E-01 -ZBTB34 1.83E-01 -ADSL 1.83E-01 -EDN1 1.83E-01 -FGF21 1.83E-01 -GPRC5C 1.83E-01 -DCAF6 1.83E-01 -ATP6V0B 1.83E-01 -EIF4A2 1.83E-01 -UST 1.83E-01 -MAP3K3 1.83E-01 -F13A1 1.83E-01 -PIK3CD 1.83E-01 -DPYSL4 1.83E-01 -BZW2 1.84E-01 -PIAS2 1.84E-01 -GJA4 1.84E-01 -SLC7A6 1.84E-01 -ATP5C1 1.84E-01 -FIBIN 1.84E-01 -SLC45A1 1.84E-01 -MRPS5 1.84E-01 -AQP9 1.84E-01 -MMGT1 1.84E-01 -ID3 1.84E-01 -RAF1 1.84E-01 -SPOCK2 1.84E-01 -PRPF8 1.84E-01 -PTBP1 1.84E-01 -TNFSF14 1.85E-01 -SLC12A8 1.85E-01 -FERD3L 1.85E-01 -EVL 1.85E-01 -SPIN3 1.85E-01 -SAR1A 1.85E-01 -PRDM10 1.85E-01 -KRT82 1.85E-01 -PLOD2 1.85E-01 -TYROBP 1.85E-01 -POU2F2 1.85E-01 -C1GALT1 1.85E-01 -BAG5 1.85E-01 -IFITM3 1.85E-01 -CHIC2 1.86E-01 -AP2S1 1.86E-01 -BCL2L11 1.86E-01 -RASSF8 1.86E-01 -DUSP7 1.86E-01 -NHLRC1 1.86E-01 -TROAP 1.86E-01 -HTR2A 1.86E-01 -TNFRSF14 1.86E-01 -LRFN3 1.86E-01 -LRRTM3 1.86E-01 -NPR1 1.86E-01 -SMARCC1 1.86E-01 -SERPINB6 1.86E-01 -CNTNAP2 1.86E-01 -IGF2BP1 1.87E-01 -GANC 1.87E-01 -KRTAP9-3 1.87E-01 -FICD 1.87E-01 -CGA 1.87E-01 -SLC5A4 1.87E-01 -ARIH2 1.87E-01 -SLC19A1 1.87E-01 -MYO1A 1.87E-01 -HSPA5 1.87E-01 -KDM6A 1.87E-01 -MEGF6 1.87E-01 -GLCCI1 1.87E-01 -E4F1 1.87E-01 -HPCAL1 1.88E-01 -RNF121 1.88E-01 -GABRE 1.88E-01 -APBA1 1.88E-01 -PFKFB2 1.88E-01 -GKAP1 1.88E-01 -SGCB 1.88E-01 -ACOX3 1.88E-01 -KRT73 1.88E-01 -UBE2F 1.88E-01 -SRL 1.88E-01 -ZFPM2 1.88E-01 -MED7 1.88E-01 -HBG2 1.88E-01 -ACOX1 1.88E-01 -DTD1 1.89E-01 -CRAT 1.89E-01 -DLX2 1.89E-01 -ZNF281 1.89E-01 -PBX1 1.89E-01 -FAF1 1.89E-01 -INTU 1.89E-01 -C1S 1.89E-01 -LIPC 1.89E-01 -ROR1 1.89E-01 -VSNL1 1.89E-01 -CCND1 1.89E-01 -JAK2 1.89E-01 -CYP4F11 1.89E-01 -REEP4 1.90E-01 -MAN2B1 1.90E-01 -CDK2AP2 1.90E-01 -MAGEE1 1.90E-01 -RPRM 1.90E-01 -DRD1 1.90E-01 -EPHB1 1.90E-01 -ASAP1 1.90E-01 -EFNA3 1.90E-01 -KRT33A 1.90E-01 -KRAS 1.90E-01 -ANKRD13C 1.90E-01 -BCAP29 1.90E-01 -KHSRP 1.90E-01 -CLTC 1.90E-01 -RASA3 1.91E-01 -PAM 1.91E-01 -DTX3 1.91E-01 -PLXNA4 1.91E-01 -FKBP4 1.91E-01 -CNOT1 1.91E-01 -RUSC2 1.91E-01 -ARHGEF2 1.91E-01 -DYM 1.91E-01 -TYRP1 1.91E-01 -MUT 1.91E-01 -KRT17 1.91E-01 -INA 1.91E-01 -YPEL1 1.91E-01 -KRT38 1.92E-01 -TRPV3 1.92E-01 -TFE3 1.92E-01 -HNRNPU 1.92E-01 -SLC19A3 1.92E-01 -TMEM174 1.92E-01 -BRIX1 1.92E-01 -ILF3 1.92E-01 -KRT33B 1.92E-01 -LRP10 1.92E-01 -RING1 1.92E-01 -SEC61A2 1.92E-01 -BAZ1A 1.92E-01 -TWF2 1.92E-01 -PPP4R2 1.92E-01 -ESRRB 1.93E-01 -CNRIP1 1.93E-01 -LMCD1 1.93E-01 -FAM53B 1.93E-01 -TIMM50 1.93E-01 -DRAP1 1.93E-01 -NUDT11 1.93E-01 -FHL3 1.93E-01 -CRTC1 1.93E-01 -RNASEH2B 1.93E-01 -WDR48 1.93E-01 -PTPN9 1.93E-01 -PBX3 1.93E-01 -ATP6V0D1 1.93E-01 -HMGCS2 1.94E-01 -CDH8 1.94E-01 -ITCH 1.94E-01 -PPP2R2C 1.94E-01 -FGB 1.94E-01 -MRI1 1.94E-01 -VNN1 1.94E-01 -UBE2S 1.94E-01 -CGGBP1 1.94E-01 -TNF 1.94E-01 -RBM25 1.94E-01 -NDUFS8 1.94E-01 -CCDC132 1.94E-01 -SLC7A9 1.94E-01 -TMEM65 1.94E-01 -MIP 1.95E-01 -TRPC3 1.95E-01 -ILK 1.95E-01 -KRT85 1.95E-01 -HEATR1 1.95E-01 -CLIP3 1.95E-01 -POU2F3 1.95E-01 -KRT35 1.95E-01 -GDF10 1.95E-01 -DLX3 1.95E-01 -DAAM2 1.95E-01 -LDLRAD3 1.95E-01 -DNAL4 1.95E-01 -CDV3 1.95E-01 -C10orf12 1.96E-01 -KIAA2022 1.96E-01 -TNFRSF10B 1.96E-01 -MYH15 1.96E-01 -GABRG3 1.96E-01 -HSD17B1 1.96E-01 -OPALIN 1.96E-01 -KDR 1.96E-01 -CD14 1.96E-01 -ADRA1B 1.96E-01 -TMPRSS11A 1.96E-01 -FAM135B 1.96E-01 -ACADS 1.96E-01 -FHL5 1.96E-01 -FAM192A 1.96E-01 -COL4A3BP 1.97E-01 -ATP6AP2 1.97E-01 -LPL 1.97E-01 -SGTB 1.97E-01 -ZNF384 1.97E-01 -CCDC12 1.97E-01 -OLFML2A 1.97E-01 -PSMD11 1.97E-01 -VPS4A 1.97E-01 -BET1L 1.97E-01 -NOTUM 1.97E-01 -TIMP2 1.97E-01 -RTN4R 1.97E-01 -GRB10 1.97E-01 -SLC5A11 1.98E-01 -ATL1 1.98E-01 -CACNG4 1.98E-01 -RBMX2 1.98E-01 -HNRNPA3 1.98E-01 -NOVA1 1.98E-01 -RAD54B 1.98E-01 -VAV2 1.98E-01 -MYO5C 1.98E-01 -NDUFAF4 1.98E-01 -TMEM229B 1.98E-01 -AMDHD2 1.98E-01 -GMDS 1.98E-01 -DOLK 1.98E-01 -SON 1.98E-01 -POLD3 1.99E-01 -NFE2L2 1.99E-01 -KLK13 1.99E-01 -KRT84 1.99E-01 -NKX2-2 1.99E-01 -TMEM53 1.99E-01 -KLHL3 1.99E-01 -VAV1 1.99E-01 -AQP5 1.99E-01 -PITPNB 1.99E-01 -KRT12 1.99E-01 -OLFML2B 1.99E-01 -FBXW2 1.99E-01 -AQP2 1.99E-01 -C21orf59 2.00E-01 -TOLLIP 2.00E-01 -SLC1A6 2.00E-01 -DCAF8L1 2.00E-01 -KDM6B 2.00E-01 -ADIPOQ 2.00E-01 -ADCY5 2.00E-01 -AMBRA1 2.00E-01 -SEC62 2.00E-01 -KLHL28 2.00E-01 -TULP2 2.00E-01 -KLF15 2.00E-01 -NANOG 2.00E-01 -SPEM1 2.00E-01 -TNFSF13 2.00E-01 -SLC26A10 2.01E-01 -AFG3L2 2.01E-01 -CADM2 2.01E-01 -CCNB1IP1 2.01E-01 -GGT7 2.01E-01 -SPRYD3 2.01E-01 -PRKCD 2.01E-01 -PPP1R13B 2.01E-01 -CHAD 2.01E-01 -KIAA1737 2.01E-01 -ALKBH4 2.01E-01 -CORIN 2.01E-01 -DCAF4L1 2.01E-01 -BRD2 2.01E-01 -XYLT1 2.02E-01 -MMP2 2.02E-01 -GSTCD 2.02E-01 -LPGAT1 2.02E-01 -ALK 2.02E-01 -ZBTB47 2.02E-01 -HTR3A 2.02E-01 -ANK3 2.02E-01 -NPR2 2.02E-01 -CRCP 2.02E-01 -MAPKAPK2 2.02E-01 -DGKD 2.02E-01 -RAI1 2.02E-01 -SLC26A2 2.02E-01 -MORC3 2.02E-01 -TMEM72 2.03E-01 -RDX 2.03E-01 -HMGCR 2.03E-01 -MITF 2.03E-01 -DSCR3 2.03E-01 -MYO7B 2.03E-01 -GAL3ST1 2.03E-01 -TRAM1 2.03E-01 -TOX 2.03E-01 -DCLK3 2.03E-01 -TWISTNB 2.03E-01 -B4GALT1 2.03E-01 -MFSD6L 2.03E-01 -CTH 2.03E-01 -PPT1 2.04E-01 -BCKDHA 2.04E-01 -IL31 2.04E-01 -ZNF217 2.04E-01 -LUC7L 2.04E-01 -CLDN6 2.04E-01 -DISP2 2.04E-01 -NRXN2 2.04E-01 -MTA2 2.04E-01 -ZNF513 2.04E-01 -COPZ1 2.04E-01 -ATP8A1 2.04E-01 -TIMP1 2.04E-01 -SERPINB13 2.04E-01 -PGRMC1 2.04E-01 -NRARP 2.05E-01 -GPR45 2.05E-01 -SYNC 2.05E-01 -AFF2 2.05E-01 -IFFO1 2.05E-01 -HDGFRP3 2.05E-01 -MIOX 2.05E-01 -KLHDC10 2.05E-01 -RCE1 2.05E-01 -SULT1A1 2.05E-01 -ATL2 2.05E-01 -HRAS 2.05E-01 -SFTPA1 2.05E-01 -CDC42SE2 2.05E-01 -KIF1B 2.06E-01 -ADAM10 2.06E-01 -TMEM39B 2.06E-01 -AP2M1 2.06E-01 -UPP1 2.06E-01 -AMHR2 2.06E-01 -MCCC2 2.06E-01 -RAG2 2.06E-01 -KCNIP3 2.06E-01 -HOXB5 2.06E-01 -NKX6-3 2.06E-01 -MB 2.06E-01 -TNFRSF10D 2.06E-01 -G0S2 2.06E-01 -SPEN 2.06E-01 -ABLIM1 2.07E-01 -CD8B 2.07E-01 -PMM2 2.07E-01 -ECEL1 2.07E-01 -F11 2.07E-01 -KLF3 2.07E-01 -MEMO1 2.07E-01 -HEPHL1 2.07E-01 -DMWD 2.07E-01 -B3GNT2 2.07E-01 -KCTD16 2.07E-01 -KRT71 2.07E-01 -RIMKLA 2.07E-01 -MARCH6 2.07E-01 -NDUFS1 2.08E-01 -SIAE 2.08E-01 -RDH11 2.08E-01 -CATSPER3 2.08E-01 -SCO1 2.08E-01 -DGUOK 2.08E-01 -THYN1 2.08E-01 -SH3GLB1 2.08E-01 -KATNAL2 2.08E-01 -GRIK4 2.08E-01 -HSD17B13 2.08E-01 -RNF213 2.08E-01 -TPSD1 2.08E-01 -CTNNB1 2.08E-01 -PEAR1 2.08E-01 -FGF12 2.09E-01 -SERPINB9 2.09E-01 -MYOC 2.09E-01 -SLC6A3 2.09E-01 -CLDN18 2.09E-01 -HSF4 2.09E-01 -ADD3 2.09E-01 -LMO3 2.09E-01 -TYK2 2.09E-01 -ARPP19 2.09E-01 -PKIB 2.09E-01 -LRRC7 2.09E-01 -DOK4 2.09E-01 -DHRS1 2.09E-01 -SERPINB3 2.10E-01 -DMRTC2 2.10E-01 -KRT20 2.10E-01 -GHR 2.10E-01 -CLDN1 2.10E-01 -KRTAP21-1 2.10E-01 -MTHFR 2.10E-01 -MRE11A 2.10E-01 -ANAPC11 2.10E-01 -PRICKLE3 2.10E-01 -FAM102A 2.10E-01 -SF3A1 2.10E-01 -KLF7 2.10E-01 -EPHB3 2.10E-01 -FAF2 2.10E-01 -NIPAL4 2.11E-01 -C1QB 2.11E-01 -PLG 2.11E-01 -TNFRSF11B 2.11E-01 -ACLY 2.11E-01 -PRSS23 2.11E-01 -TAF15 2.11E-01 -KIAA1598 2.11E-01 -ATP5D 2.11E-01 -SLC25A12 2.11E-01 -TRIM32 2.11E-01 -MTF1 2.11E-01 -C1orf43 2.11E-01 -SPATA5L1 2.11E-01 -JHDM1D 2.12E-01 -BDNF 2.12E-01 -SCD 2.12E-01 -PLA1A 2.12E-01 -EIF2S1 2.12E-01 -TCEAL2 2.12E-01 -PI4KB 2.12E-01 -OXCT1 2.12E-01 -AGPAT4 2.12E-01 -BCL2L14 2.12E-01 -HOXA9 2.12E-01 -PCDH9 2.12E-01 -MPPED1 2.12E-01 -PTMA 2.12E-01 -RNF130 2.12E-01 -ZFP91 2.13E-01 -PDYN 2.13E-01 -WDR37 2.13E-01 -SERPINA11 2.13E-01 -MAN1A2 2.13E-01 -CDKN1B 2.13E-01 -C19orf54 2.13E-01 -PANK1 2.13E-01 -VPS4B 2.13E-01 -FAM169A 2.13E-01 -ZNF496 2.13E-01 -GDAP1 2.13E-01 -LRRC41 2.13E-01 -CCRN4L 2.13E-01 -AGPAT1 2.14E-01 -CYC1 2.14E-01 -TRIP4 2.14E-01 -TNNT3 2.14E-01 -RCAN1 2.14E-01 -STAG1 2.14E-01 -EIF3I 2.14E-01 -HNF4G 2.14E-01 -LONRF3 2.14E-01 -FAM155A 2.14E-01 -KRTAP12-3 2.14E-01 -PDGFC 2.14E-01 -CAPN5 2.14E-01 -FMNL3 2.14E-01 -ATP11C 2.14E-01 -HOXA1 2.15E-01 -TLE1 2.15E-01 -GPAA1 2.15E-01 -PLK1 2.15E-01 -UGCG 2.15E-01 -CISD2 2.15E-01 -JPH1 2.15E-01 -BMP15 2.15E-01 -PRSS38 2.15E-01 -CRADD 2.15E-01 -P4HTM 2.15E-01 -C19orf44 2.15E-01 -VPS28 2.15E-01 -C5orf15 2.15E-01 -RCAN2 2.16E-01 -HTR1D 2.16E-01 -TMCC2 2.16E-01 -FAM19A2 2.16E-01 -CLPP 2.16E-01 -HOXA11 2.16E-01 -PPAT 2.16E-01 -KRT23 2.16E-01 -SDC3 2.16E-01 -U2AF2 2.16E-01 -DNAJB1 2.16E-01 -NAGS 2.16E-01 -ZC3H18 2.16E-01 -HAND1 2.16E-01 -PRRG4 2.16E-01 -CREB5 2.17E-01 -SLC2A10 2.17E-01 -MATR3 2.17E-01 -EIF3J 2.17E-01 -RNF138 2.17E-01 -TMEM19 2.17E-01 -SYCE2 2.17E-01 -TCEAL5 2.17E-01 -RTN1 2.17E-01 -TELO2 2.17E-01 -TAL2 2.17E-01 -NFYA 2.17E-01 -ARHGEF1 2.17E-01 -FOXD4L1 2.17E-01 -GXYLT1 2.17E-01 -TNFRSF13B 2.18E-01 -QSER1 2.18E-01 -HOXC10 2.18E-01 -REV3L 2.18E-01 -RNF152 2.18E-01 -BFSP2 2.18E-01 -STOML3 2.18E-01 -MYL3 2.18E-01 -MKL1 2.18E-01 -HBP1 2.18E-01 -FLT3 2.18E-01 -SLC4A5 2.18E-01 -IKZF4 2.18E-01 -ARSK 2.18E-01 -ATG9A 2.19E-01 -OLFM1 2.19E-01 -CRBN 2.19E-01 -PGAP1 2.19E-01 -EFNB3 2.19E-01 -TARBP2 2.19E-01 -ATP5J 2.19E-01 -KCNE3 2.19E-01 -TGFB1 2.19E-01 -MOBP 2.19E-01 -PRKG2 2.19E-01 -GPR20 2.19E-01 -MAMSTR 2.19E-01 -CD81 2.19E-01 -HMX2 2.19E-01 -TNNC1 2.20E-01 -ZFC3H1 2.20E-01 -HNRNPA1 2.20E-01 -STRN4 2.20E-01 -ZBTB4 2.20E-01 -CHML 2.20E-01 -DYRK1A 2.20E-01 -RSRC2 2.20E-01 -MYT1 2.20E-01 -PCBP2 2.20E-01 -CMIP 2.20E-01 -RAC1 2.20E-01 -TBX6 2.20E-01 -RGMB 2.20E-01 -NUDT10 2.21E-01 -SLC5A8 2.21E-01 -MAB21L2 2.21E-01 -SERPINB2 2.21E-01 -PLCG2 2.21E-01 -SYS1 2.21E-01 -AGAP3 2.21E-01 -ATP6V1A 2.21E-01 -KRT39 2.21E-01 -CNGB3 2.21E-01 -CAT 2.21E-01 -SGPP2 2.21E-01 -MSGN1 2.21E-01 -UCHL1 2.21E-01 -T 2.21E-01 -ASXL3 2.22E-01 -C3orf58 2.22E-01 -DIAPH2 2.22E-01 -RNF11 2.22E-01 -SPCS2 2.22E-01 -PPP1CB 2.22E-01 -SEC24B 2.22E-01 -NEU2 2.22E-01 -ARHGDIA 2.22E-01 -FGR 2.22E-01 -HLX 2.22E-01 -ATF7 2.22E-01 -JMY 2.22E-01 -OLFML1 2.22E-01 -TCTN3 2.23E-01 -ARSH 2.23E-01 -C15orf40 2.23E-01 -RNF2 2.23E-01 -HSD11B1 2.23E-01 -ADIPOR1 2.23E-01 -HELLS 2.23E-01 -VAC14 2.23E-01 -EPHA7 2.23E-01 -COPS8 2.23E-01 -SIX6 2.23E-01 -ITGB6 2.23E-01 -NCK2 2.23E-01 -NAP1L4 2.23E-01 -PLEKHH3 2.23E-01 -PLEKHF1 2.24E-01 -MKLN1 2.24E-01 -TBC1D20 2.24E-01 -CDC40 2.24E-01 -FNDC5 2.24E-01 -MMEL1 2.24E-01 -GATAD2A 2.24E-01 -AXIN2 2.24E-01 -DDI2 2.24E-01 -MX1 2.24E-01 -RASGEF1A 2.24E-01 -CXorf65 2.24E-01 -ERP29 2.24E-01 -CNN2 2.24E-01 -PHF7 2.25E-01 -SYT2 2.25E-01 -PCDH1 2.25E-01 -AP3D1 2.25E-01 -ARL4A 2.25E-01 -SNRPD2 2.25E-01 -RCC2 2.25E-01 -TRPC6 2.25E-01 -CPEB4 2.25E-01 -LPXN 2.25E-01 -GPR158 2.25E-01 -POLR2H 2.25E-01 -EMCN 2.25E-01 -FER1L6 2.25E-01 -SCD5 2.25E-01 -STX6 2.26E-01 -BRD3 2.26E-01 -PYY 2.26E-01 -PKIG 2.26E-01 -TGM5 2.26E-01 -ATXN7L2 2.26E-01 -PRKAB2 2.26E-01 -CDH22 2.26E-01 -WNT11 2.26E-01 -DUSP10 2.26E-01 -PQBP1 2.26E-01 -SHBG 2.26E-01 -FGF13 2.26E-01 -MPND 2.26E-01 -TTC17 2.27E-01 -PHC3 2.27E-01 -SERPINA3 2.27E-01 -AQP7 2.27E-01 -RFT1 2.27E-01 -BEST3 2.27E-01 -PIK3R5 2.27E-01 -ATP9B 2.27E-01 -GRIK1 2.27E-01 -SOS2 2.27E-01 -GPR12 2.27E-01 -GINS3 2.27E-01 -CX3CL1 2.27E-01 -AKAP8L 2.27E-01 -MANEA 2.27E-01 -SPDEF 2.28E-01 -UBE2G1 2.28E-01 -IPMK 2.28E-01 -IQSEC2 2.28E-01 -TMEM222 2.28E-01 -CAV2 2.28E-01 -FRMD3 2.28E-01 -IRF3 2.28E-01 -TMLHE 2.28E-01 -BIVM 2.28E-01 -VASP 2.28E-01 -NAV3 2.28E-01 -CELSR2 2.28E-01 -DRGX 2.28E-01 -TMEM180 2.29E-01 -GJA10 2.29E-01 -CDA 2.29E-01 -PUM1 2.29E-01 -HSD17B3 2.29E-01 -HIST1H3F 2.29E-01 -VEGFC 2.29E-01 -ZBTB10 2.29E-01 -FBLIM1 2.29E-01 -HSPB8 2.29E-01 -TECTA 2.29E-01 -C9orf142 2.29E-01 -IKZF5 2.29E-01 -ISX 2.29E-01 -HDAC7 2.29E-01 -CDH20 2.30E-01 -SLC7A11 2.30E-01 -TIPRL 2.30E-01 -NDN 2.30E-01 -CHRND 2.30E-01 -RAB8A 2.30E-01 -PTMS 2.30E-01 -PNPLA7 2.30E-01 -SIT1 2.30E-01 -DIAPH3 2.30E-01 -MXD1 2.30E-01 -FAM78A 2.30E-01 -ANGPT2 2.30E-01 -GDF11 2.30E-01 -PCDH7 2.31E-01 -PCDH20 2.31E-01 -EVI5L 2.31E-01 -PAXIP1 2.31E-01 -PRKAR2A 2.31E-01 -BCKDHB 2.31E-01 -TNRC6A 2.31E-01 -DGKH 2.31E-01 -C1QC 2.31E-01 -FAM177A1 2.31E-01 -DNAJC28 2.31E-01 -CLN3 2.31E-01 -POU1F1 2.31E-01 -MYO3B 2.31E-01 -PTDSS2 2.31E-01 -SNAI1 2.32E-01 -AMY2B 2.32E-01 -DCUN1D4 2.32E-01 -NIPAL3 2.32E-01 -NDFIP1 2.32E-01 -DYNLRB1 2.32E-01 -PCDH10 2.32E-01 -TSNAX 2.32E-01 -GLUD1 2.32E-01 -KRT27 2.32E-01 -CDKN1A 2.32E-01 -LGR6 2.32E-01 -MYLIP 2.32E-01 -GRIN3A 2.32E-01 -HSD17B4 2.33E-01 -BBS2 2.33E-01 -CHMP1A 2.33E-01 -ABCD2 2.33E-01 -AHCTF1 2.33E-01 -DICER1 2.33E-01 -EGR2 2.33E-01 -PLAGL2 2.33E-01 -SIN3B 2.33E-01 -RUVBL1 2.33E-01 -TRAPPC3 2.33E-01 -GATSL3 2.33E-01 -C1orf216 2.33E-01 -PPFIA1 2.33E-01 -MAPK10 2.33E-01 -CCDC89 2.34E-01 -MYO16 2.34E-01 -KRT24 2.34E-01 -RNLS 2.34E-01 -CDC23 2.34E-01 -CABP7 2.34E-01 -SELT 2.34E-01 -TSPAN5 2.34E-01 -KEL 2.34E-01 -MAP3K8 2.34E-01 -C10orf137 2.34E-01 -PRLR 2.34E-01 -PEX10 2.34E-01 -TMEM168 2.34E-01 -INSIG2 2.35E-01 -FIP1L1 2.35E-01 -SUCLG1 2.35E-01 -SERPINB4 2.35E-01 -KCNA3 2.35E-01 -PARD6G 2.35E-01 -SNRPD3 2.35E-01 -CRISPLD2 2.35E-01 -HP 2.35E-01 -ANAPC7 2.35E-01 -QTRT1 2.35E-01 -CRTC2 2.35E-01 -PCSK4 2.35E-01 -CCBL1 2.35E-01 -C16orf70 2.35E-01 -MSL1 2.36E-01 -SMCHD1 2.36E-01 -NAA25 2.36E-01 -PAK4 2.36E-01 -MGLL 2.36E-01 -JMJD6 2.36E-01 -SAMD14 2.36E-01 -TLE4 2.36E-01 -BRMS1L 2.36E-01 -AWAT2 2.36E-01 -MSTN 2.36E-01 -FBXO8 2.36E-01 -FGF14 2.36E-01 -OMG 2.36E-01 -MFN1 2.37E-01 -PRND 2.37E-01 -EYA3 2.37E-01 -CAPZA3 2.37E-01 -KIF1C 2.37E-01 -BMP4 2.37E-01 -PDE8B 2.37E-01 -HN1L 2.37E-01 -SMCR8 2.37E-01 -TM2D3 2.37E-01 -PAPL 2.37E-01 -TNFRSF8 2.37E-01 -LGI4 2.37E-01 -ST3GAL2 2.37E-01 -C12orf56 2.37E-01 -PRPF38B 2.38E-01 -CD22 2.38E-01 -ADIPOR2 2.38E-01 -ABCB10 2.38E-01 -PRRG1 2.38E-01 -BCL2 2.38E-01 -WFIKKN2 2.38E-01 -ZNF644 2.38E-01 -NFATC2 2.38E-01 -ZP3 2.38E-01 -TATDN1 2.38E-01 -COCH 2.38E-01 -MSI2 2.38E-01 -EPOR 2.38E-01 -MEGF11 2.39E-01 -INSRR 2.39E-01 -SLC34A3 2.39E-01 -FAH 2.39E-01 -FAM131B 2.39E-01 -ZNF768 2.39E-01 -NOL12 2.39E-01 -PPRC1 2.39E-01 -RSPH9 2.39E-01 -FOXD4 2.39E-01 -ARHGAP31 2.39E-01 -PTHLH 2.39E-01 -SMURF1 2.39E-01 -SGCZ 2.39E-01 -FAM111A 2.39E-01 -RBM27 2.40E-01 -NPTX1 2.40E-01 -SLC7A13 2.40E-01 -SLC35A2 2.40E-01 -FUNDC2 2.40E-01 -TRAPPC10 2.40E-01 -SH3BP5L 2.40E-01 -ZBTB46 2.40E-01 -SMG6 2.40E-01 -TRIM24 2.40E-01 -AMICA1 2.40E-01 -PRR5L 2.40E-01 -KLHL4 2.40E-01 -ORMDL2 2.40E-01 -GRHL2 2.41E-01 -BEND5 2.41E-01 -EPHB6 2.41E-01 -VPS52 2.41E-01 -GRK5 2.41E-01 -DDX46 2.41E-01 -LIPI 2.41E-01 -AXL 2.41E-01 -RASAL2 2.41E-01 -ARHGEF6 2.41E-01 -PSMC4 2.41E-01 -ARHGEF12 2.41E-01 -NT5C1A 2.41E-01 -SLC6A8 2.41E-01 -KIF4A 2.41E-01 -ATP13A4 2.42E-01 -VPS29 2.42E-01 -FRMD5 2.42E-01 -SLC35C2 2.42E-01 -MFSD5 2.42E-01 -SMO 2.42E-01 -CAMKV 2.42E-01 -IMPAD1 2.42E-01 -VWC2L 2.42E-01 -IRAK1 2.42E-01 -PLOD3 2.42E-01 -VPS72 2.42E-01 -EAF1 2.42E-01 -SECISBP2L 2.42E-01 -LRRC25 2.43E-01 -SDS 2.43E-01 -DRG1 2.43E-01 -NEUROD4 2.43E-01 -FNIP2 2.43E-01 -MAN2A1 2.43E-01 -GPT2 2.43E-01 -TMEM109 2.43E-01 -RAI2 2.43E-01 -MUC5B 2.43E-01 -RAB1B 2.43E-01 -TM9SF2 2.43E-01 -TTPAL 2.43E-01 -QDPR 2.43E-01 -E2F7 2.43E-01 -TUBB3 2.44E-01 -TAT 2.44E-01 -FRRS1 2.44E-01 -TSPAN18 2.44E-01 -DACT1 2.44E-01 -SLC6A17 2.44E-01 -OTUB1 2.44E-01 -VGLL4 2.44E-01 -ADCY3 2.44E-01 -WDR76 2.44E-01 -ACTA1 2.44E-01 -MRPL54 2.44E-01 -HS6ST3 2.44E-01 -BAZ2B 2.44E-01 -VEGFB 2.45E-01 -BAZ1B 2.45E-01 -CTRL 2.45E-01 -OIT3 2.45E-01 -MAGOH 2.45E-01 -GEMIN7 2.45E-01 -C21orf62 2.45E-01 -MRPL33 2.45E-01 -PPM1E 2.45E-01 -POLR1D 2.45E-01 -XIAP 2.45E-01 -NFIC 2.45E-01 -JOSD1 2.45E-01 -AHCY 2.45E-01 -ETFA 2.45E-01 -LRRTM2 2.46E-01 -TIMP4 2.46E-01 -OLFM4 2.46E-01 -AUP1 2.46E-01 -NTNG2 2.46E-01 -KIAA1257 2.46E-01 -SPAG5 2.46E-01 -SECTM1 2.46E-01 -CPLX3 2.46E-01 -MTOR 2.46E-01 -CALML3 2.46E-01 -OXSM 2.46E-01 -VEZF1 2.46E-01 -NPAS4 2.46E-01 -SRFBP1 2.47E-01 -COPS6 2.47E-01 -ZNF532 2.47E-01 -NUP214 2.47E-01 -TET1 2.47E-01 -NUP50 2.47E-01 -SNAP29 2.47E-01 -TSTA3 2.47E-01 -MESDC2 2.47E-01 -SAMHD1 2.47E-01 -ARFRP1 2.47E-01 -FBXL7 2.47E-01 -AP1G1 2.47E-01 -CMAS 2.47E-01 -MTMR6 2.47E-01 -C8orf46 2.48E-01 -DNAJB14 2.48E-01 -SERTAD1 2.48E-01 -C14orf166 2.48E-01 -ALPI 2.48E-01 -RELA 2.48E-01 -TGM2 2.48E-01 -ATXN10 2.48E-01 -SULT1A2 2.48E-01 -PLAU 2.48E-01 -YPEL4 2.48E-01 -TF 2.48E-01 -SLC16A14 2.48E-01 -DNAJC14 2.48E-01 -BBS10 2.49E-01 -LIPG 2.49E-01 -FGF7 2.49E-01 -UQCRFS1 2.49E-01 -TYRO3 2.49E-01 -CDC42EP3 2.49E-01 -ESX1 2.49E-01 -PAK2 2.49E-01 -ACTR10 2.49E-01 -ELOVL5 2.49E-01 -MED9 2.49E-01 -CRIM1 2.49E-01 -SHC3 2.49E-01 -KIAA0895L 2.49E-01 -RNF103 2.49E-01 -C2orf42 2.50E-01 -C16orf91 2.50E-01 -PPM1L 2.50E-01 -CYB5R2 2.50E-01 -ATP5J2 2.50E-01 -BCL9 2.50E-01 -ZNF622 2.50E-01 -LATS1 2.50E-01 -ARSJ 2.50E-01 -MRPL21 2.50E-01 -SPRED1 2.50E-01 -PIGF 2.50E-01 -NXF1 2.50E-01 -BHLHB9 2.50E-01 -TMEM205 2.50E-01 -RBPMS2 2.51E-01 -CARD11 2.51E-01 -SNX3 2.51E-01 -FITM1 2.51E-01 -OVOL2 2.51E-01 -CTSS 2.51E-01 -CTDP1 2.51E-01 -SLITRK4 2.51E-01 -HS2ST1 2.51E-01 -NPHS2 2.51E-01 -PRSS50 2.51E-01 -ALDH3A2 2.51E-01 -SNIP1 2.51E-01 -CDK2 2.51E-01 -MRPL42 2.52E-01 -SPTLC3 2.52E-01 -MEF2B 2.52E-01 -NPY 2.52E-01 -KCNJ8 2.52E-01 -LACE1 2.52E-01 -CDH4 2.52E-01 -GMPS 2.52E-01 -BRPF1 2.52E-01 -PHF1 2.52E-01 -GALC 2.52E-01 -ZC3H12B 2.52E-01 -IL1B 2.52E-01 -IPO9 2.52E-01 -KLK4 2.52E-01 -MRPL41 2.53E-01 -GDAP1L1 2.53E-01 -GABRA3 2.53E-01 -PROP1 2.53E-01 -KCTD13 2.53E-01 -LDOC1L 2.53E-01 -ERLIN2 2.53E-01 -DGKA 2.53E-01 -GMEB1 2.53E-01 -AK5 2.53E-01 -MAP1B 2.53E-01 -LOX 2.53E-01 -DDX1 2.53E-01 -CUL7 2.53E-01 -DYNC1LI2 2.54E-01 -TRIO 2.54E-01 -EPC2 2.54E-01 -CCNI 2.54E-01 -CD28 2.54E-01 -CCBE1 2.54E-01 -FAHD1 2.54E-01 -KIF3C 2.54E-01 -HSDL1 2.54E-01 -FER 2.54E-01 -AES 2.54E-01 -ORMDL3 2.54E-01 -RNASEH2A 2.54E-01 -ZHX1 2.54E-01 -GALK1 2.54E-01 -ZFAND1 2.55E-01 -KIAA0895 2.55E-01 -FOS 2.55E-01 -ATAD1 2.55E-01 -TMEM161A 2.55E-01 -PLAGL1 2.55E-01 -EPB41L4A 2.55E-01 -RAPGEF2 2.55E-01 -FOXN4 2.55E-01 -GAR1 2.55E-01 -FAM19A1 2.55E-01 -ALOX5 2.55E-01 -CIR1 2.55E-01 -CRYAA 2.55E-01 -KRTAP19-7 2.56E-01 -MFAP2 2.56E-01 -SDSL 2.56E-01 -GPR4 2.56E-01 -RAPSN 2.56E-01 -PNLIP 2.56E-01 -MSC 2.56E-01 -ENSA 2.56E-01 -PRRC1 2.56E-01 -DENND1A 2.56E-01 -SPARC 2.56E-01 -C8orf33 2.56E-01 -OSBP 2.56E-01 -GSS 2.56E-01 -SFTPB 2.56E-01 -B3GALT2 2.57E-01 -EHD1 2.57E-01 -SLC25A23 2.57E-01 -TBX10 2.57E-01 -ABHD13 2.57E-01 -ALOX12B 2.57E-01 -DLX6 2.57E-01 -PDAP1 2.57E-01 -TMEM215 2.57E-01 -RBM42 2.57E-01 -NAGA 2.57E-01 -FBXO32 2.57E-01 -SPATA13 2.57E-01 -DSCAML1 2.57E-01 -MAP4K4 2.58E-01 -RBM26 2.58E-01 -FGF1 2.58E-01 -HSPB2 2.58E-01 -WDR7 2.58E-01 -CRB3 2.58E-01 -CACNA2D1 2.58E-01 -NRN1L 2.58E-01 -CLDN4 2.58E-01 -PIGV 2.58E-01 -NADSYN1 2.58E-01 -CD79A 2.58E-01 -AZU1 2.58E-01 -SLC19A2 2.58E-01 -VWA2 2.58E-01 -CD70 2.59E-01 -RBM4B 2.59E-01 -ARID2 2.59E-01 -IGLON5 2.59E-01 -NPY1R 2.59E-01 -BNIP3L 2.59E-01 -RELL1 2.59E-01 -CYP46A1 2.59E-01 -ACTBL2 2.59E-01 -PSPC1 2.59E-01 -B4GALT2 2.59E-01 -HSP90AB1 2.59E-01 -CRELD2 2.59E-01 -PIAS3 2.59E-01 -SLA2 2.60E-01 -C2 2.60E-01 -HP1BP3 2.60E-01 -TXN 2.60E-01 -KPNA1 2.60E-01 -ZCCHC6 2.60E-01 -AFF4 2.60E-01 -BAG1 2.60E-01 -LATS2 2.60E-01 -BAHD1 2.60E-01 -MDGA2 2.60E-01 -POLR2A 2.60E-01 -H2AFV 2.60E-01 -A4GNT 2.60E-01 -MX2 2.60E-01 -DONSON 2.61E-01 -SLC10A3 2.61E-01 -TNFRSF11A 2.61E-01 -C11orf88 2.61E-01 -PROZ 2.61E-01 -ITK 2.61E-01 -DCHS1 2.61E-01 -TEX13B 2.61E-01 -CSRP1 2.61E-01 -PSAT1 2.61E-01 -RALY 2.61E-01 -THOC7 2.61E-01 -KRT4 2.61E-01 -PAK7 2.61E-01 -BMF 2.62E-01 -LGI3 2.62E-01 -UPRT 2.62E-01 -NDUFA10 2.62E-01 -PDE9A 2.62E-01 -ACOT8 2.62E-01 -TANC2 2.62E-01 -ACHE 2.62E-01 -C1RL 2.62E-01 -CREB3L3 2.62E-01 -GNS 2.62E-01 -IFT52 2.62E-01 -FAM20B 2.62E-01 -SLC22A17 2.62E-01 -PCID2 2.62E-01 -NIPA1 2.63E-01 -GOLPH3 2.63E-01 -TCTN1 2.63E-01 -NDUFB6 2.63E-01 -GLDN 2.63E-01 -MBNL2 2.63E-01 -SLC25A6 2.63E-01 -SPATA2 2.63E-01 -SENP2 2.63E-01 -RNGTT 2.63E-01 -ARL5B 2.63E-01 -ATP13A5 2.63E-01 -RAC3 2.63E-01 -DCK 2.63E-01 -H3F3A 2.64E-01 -TROVE2 2.64E-01 -SRRM5 2.64E-01 -RAB7L1 2.64E-01 -MAP3K9 2.64E-01 -MYOD1 2.64E-01 -HIST1H2AC 2.64E-01 -ATP6V1B1 2.64E-01 -DCTN3 2.64E-01 -PTRH2 2.64E-01 -HIST1H2BN 2.64E-01 -CA11 2.64E-01 -ZBED2 2.64E-01 -SMURF2 2.64E-01 -ZBTB8OS 2.64E-01 -RPRD1B 2.65E-01 -INCA1 2.65E-01 -AGPAT6 2.65E-01 -RABGAP1 2.65E-01 -CXorf22 2.65E-01 -AFTPH 2.65E-01 -IPPK 2.65E-01 -FANCI 2.65E-01 -TPRX1 2.65E-01 -TMEM91 2.65E-01 -CD93 2.65E-01 -MPI 2.65E-01 -MYO3A 2.65E-01 -MKKS 2.65E-01 -TRIM2 2.66E-01 -SHPRH 2.66E-01 -MED8 2.66E-01 -ACTR1A 2.66E-01 -PERP 2.66E-01 -WDR47 2.66E-01 -PLEKHM3 2.66E-01 -TBC1D9 2.66E-01 -ING2 2.66E-01 -BMP3 2.66E-01 -LEFTY2 2.66E-01 -ITM2A 2.66E-01 -HOXD4 2.66E-01 -SLC35F1 2.66E-01 -AATF 2.66E-01 -TAOK2 2.67E-01 -TMEM163 2.67E-01 -DPYS 2.67E-01 -MARCO 2.67E-01 -KRT25 2.67E-01 -GCN1L1 2.67E-01 -TNP1 2.67E-01 -TMEM181 2.67E-01 -DPP4 2.67E-01 -LY6E 2.67E-01 -MYD88 2.67E-01 -SLTM 2.67E-01 -ACR 2.67E-01 -NOS1AP 2.67E-01 -ZDHHC14 2.68E-01 -CACNG7 2.68E-01 -RNF180 2.68E-01 -IRF1 2.68E-01 -DAB1 2.68E-01 -NTNG1 2.68E-01 -SRM 2.68E-01 -PIK3CA 2.68E-01 -SCLY 2.68E-01 -SCN2B 2.68E-01 -TLN1 2.68E-01 -TSNAXIP1 2.68E-01 -FAM171A1 2.68E-01 -TMED2 2.68E-01 -FAM50B 2.68E-01 -ACY3 2.69E-01 -BOLA3 2.69E-01 -DGCR2 2.69E-01 -PIP5K1C 2.69E-01 -C7orf50 2.69E-01 -ANKS1B 2.69E-01 -STIM1 2.69E-01 -SH2D5 2.69E-01 -CACNG5 2.69E-01 -EPS15L1 2.69E-01 -TMEM63C 2.69E-01 -ZNF185 2.69E-01 -TSSK2 2.69E-01 -ZNF710 2.69E-01 -SLC9A7 2.70E-01 -PDHA2 2.70E-01 -INPP4A 2.70E-01 -PALM 2.70E-01 -PROS1 2.70E-01 -MCOLN1 2.70E-01 -IL23A 2.70E-01 -EDIL3 2.70E-01 -BUB3 2.70E-01 -DCAF12L2 2.70E-01 -DIAPH1 2.70E-01 -PRSS36 2.70E-01 -DYNLL1 2.70E-01 -MAPK4 2.70E-01 -TSPAN9 2.70E-01 -CDK5RAP1 2.71E-01 -GTPBP1 2.71E-01 -NAT6 2.71E-01 -DDB1 2.71E-01 -TLR7 2.71E-01 -TMEM80 2.71E-01 -ALDH1A1 2.71E-01 -APRT 2.71E-01 -MMAB 2.71E-01 -PCSK1 2.71E-01 -FNDC4 2.71E-01 -COL23A1 2.71E-01 -TMEM74 2.71E-01 -PHTF1 2.71E-01 -PHF3 2.72E-01 -NEURL4 2.72E-01 -PRKCH 2.72E-01 -ATP5G3 2.72E-01 -NODAL 2.72E-01 -SCAMP2 2.72E-01 -TSHR 2.72E-01 -CD151 2.72E-01 -TP53I13 2.72E-01 -MRPS18A 2.72E-01 -PRDM4 2.72E-01 -CYP2U1 2.72E-01 -PPAPDC2 2.72E-01 -PPP6C 2.72E-01 -RIMKLB 2.72E-01 -PSMD8 2.73E-01 -PARVG 2.73E-01 -ALG13 2.73E-01 -SETD7 2.73E-01 -C1QBP 2.73E-01 -HGD 2.73E-01 -MASP2 2.73E-01 -C6 2.73E-01 -PLEKHA5 2.73E-01 -USF1 2.73E-01 -MAP3K11 2.73E-01 -MYL4 2.73E-01 -TNFSF4 2.73E-01 -FLYWCH2 2.73E-01 -CASP8 2.74E-01 -KDM4A 2.74E-01 -SLC44A1 2.74E-01 -IPO13 2.74E-01 -CCNG1 2.74E-01 -PGAM5 2.74E-01 -TMX2 2.74E-01 -EPHB4 2.74E-01 -TSKU 2.74E-01 -ARNT2 2.74E-01 -NCL 2.74E-01 -MAB21L1 2.74E-01 -ZRANB2 2.74E-01 -FAM76B 2.74E-01 -SF3B3 2.74E-01 -ABCG8 2.75E-01 -SIKE1 2.75E-01 -POFUT2 2.75E-01 -THAP9 2.75E-01 -NLRP12 2.75E-01 -DCBLD1 2.75E-01 -MDFI 2.75E-01 -TNFRSF12A 2.75E-01 -SENP5 2.75E-01 -LPAR4 2.75E-01 -KIAA1467 2.75E-01 -C8A 2.75E-01 -PRPF38A 2.75E-01 -SLC30A6 2.75E-01 -CDCA3 2.76E-01 -C17orf49 2.76E-01 -CELA3B 2.76E-01 -WNT3A 2.76E-01 -PLCXD3 2.76E-01 -CXCR5 2.76E-01 -TTBK1 2.76E-01 -SGCD 2.76E-01 -SERPINB7 2.76E-01 -KCTD11 2.76E-01 -NUP35 2.76E-01 -HMGCL 2.76E-01 -FAM9A 2.76E-01 -DEGS1 2.76E-01 -STT3A 2.76E-01 -ZDHHC8 2.77E-01 -FAM122B 2.77E-01 -TSSC1 2.77E-01 -DUSP22 2.77E-01 -SLC31A1 2.77E-01 -NUDC 2.77E-01 -ACTR5 2.77E-01 -CUL1 2.77E-01 -RNASEH2C 2.77E-01 -APTX 2.77E-01 -CYB5B 2.77E-01 -UBL3 2.77E-01 -FADS2 2.77E-01 -LHX8 2.77E-01 -CHRNA10 2.78E-01 -TBX19 2.78E-01 -TUSC5 2.78E-01 -RRAD 2.78E-01 -RFESD 2.78E-01 -OPCML 2.78E-01 -MYL1 2.78E-01 -SLC5A12 2.78E-01 -CSDC2 2.78E-01 -PRMT8 2.78E-01 -CNTNAP1 2.78E-01 -USP49 2.78E-01 -TUBA1A 2.78E-01 -B3GALNT1 2.78E-01 -BPTF 2.78E-01 -PNPLA8 2.79E-01 -CALB1 2.79E-01 -TCEA1 2.79E-01 -HTRA3 2.79E-01 -VPS26A 2.79E-01 -FARSB 2.79E-01 -CSE1L 2.79E-01 -WDFY3 2.79E-01 -SLITRK2 2.79E-01 -EDN2 2.79E-01 -ITFG1 2.79E-01 -NAP1L3 2.79E-01 -OLFM3 2.79E-01 -ATP6AP1L 2.79E-01 -TNFRSF10A 2.80E-01 -MAPK9 2.80E-01 -LRRC1 2.80E-01 -RSRC1 2.80E-01 -DEF6 2.80E-01 -PDCD6 2.80E-01 -PSMC1 2.80E-01 -MYEOV2 2.80E-01 -RAB35 2.80E-01 -CTRC 2.80E-01 -PDZRN3 2.80E-01 -IL1RAPL2 2.80E-01 -EHD4 2.80E-01 -CUX2 2.80E-01 -TEC 2.80E-01 -OR1C1 2.81E-01 -HSD11B1L 2.81E-01 -ATP5H 2.81E-01 -UPB1 2.81E-01 -RBBP6 2.81E-01 -HIST1H2BB 2.81E-01 -KLK2 2.81E-01 -CBFA2T3 2.81E-01 -RDH16 2.81E-01 -COTL1 2.81E-01 -FXYD2 2.81E-01 -PRR15L 2.81E-01 -TIMP3 2.81E-01 -PTK6 2.81E-01 -PSMA1 2.82E-01 -EIF4G3 2.82E-01 -VAPB 2.82E-01 -GTF3C1 2.82E-01 -BZW1 2.82E-01 -CKAP4 2.82E-01 -MAP7D2 2.82E-01 -CDC42 2.82E-01 -DVL3 2.82E-01 -AKAP6 2.82E-01 -ZNF292 2.82E-01 -HIST1H3B 2.82E-01 -ZNF398 2.82E-01 -PSPH 2.82E-01 -GPR61 2.82E-01 -GNGT1 2.83E-01 -KDELR2 2.83E-01 -ZBTB33 2.83E-01 -UBE4B 2.83E-01 -POP7 2.83E-01 -LHCGR 2.83E-01 -SERPINF1 2.83E-01 -SSR2 2.83E-01 -EFNA4 2.83E-01 -PSKH1 2.83E-01 -UBN2 2.83E-01 -TGFBR3 2.83E-01 -PSMG3 2.83E-01 -BUD31 2.83E-01 -FAU 2.83E-01 -HEMGN 2.84E-01 -PHF10 2.84E-01 -IRAK4 2.84E-01 -TGM4 2.84E-01 -IMMP2L 2.84E-01 -ZFAND5 2.84E-01 -USP42 2.84E-01 -LST1 2.84E-01 -ATP10D 2.84E-01 -PLXNA3 2.84E-01 -RRAS2 2.84E-01 -THAP8 2.84E-01 -PPIE 2.84E-01 -CDC37L1 2.84E-01 -SCAP 2.85E-01 -MAN2A2 2.85E-01 -NAP1L5 2.85E-01 -KCTD2 2.85E-01 -RHOB 2.85E-01 -FES 2.85E-01 -NOP56 2.85E-01 -LHFPL5 2.85E-01 -MAST3 2.85E-01 -HMGN5 2.85E-01 -TLR10 2.85E-01 -AKTIP 2.85E-01 -ARF5 2.85E-01 -PFN2 2.85E-01 -SELENBP1 2.85E-01 -ETFDH 2.86E-01 -SPTLC1 2.86E-01 -REL 2.86E-01 -CCDC47 2.86E-01 -CXXC1 2.86E-01 -EIF5A 2.86E-01 -PTPN3 2.86E-01 -CUL5 2.86E-01 -EBAG9 2.86E-01 -BRSK2 2.86E-01 -KRT7 2.86E-01 -FCER1G 2.86E-01 -PTK2 2.86E-01 -RAB6A 2.86E-01 -IYD 2.87E-01 -CLN5 2.87E-01 -CAPZB 2.87E-01 -RBM5 2.87E-01 -FZD6 2.87E-01 -DNAJB5 2.87E-01 -PDDC1 2.87E-01 -C2orf78 2.87E-01 -ACAD8 2.87E-01 -TUBB6 2.87E-01 -ADAM17 2.87E-01 -DTWD2 2.87E-01 -RANBP1 2.87E-01 -CPXM2 2.87E-01 -FEZ1 2.87E-01 -TMEM71 2.88E-01 -TLR8 2.88E-01 -WNT7A 2.88E-01 -TNNI1 2.88E-01 -NRBP1 2.88E-01 -ADCY8 2.88E-01 -FOXRED1 2.88E-01 -PPM1A 2.88E-01 -FAM117A 2.88E-01 -MAP3K1 2.88E-01 -ACTL6B 2.88E-01 -PRKCQ 2.88E-01 -SNAP23 2.88E-01 -MAF1 2.88E-01 -YPEL3 2.89E-01 -TMEM150A 2.89E-01 -SEMA6D 2.89E-01 -SOSTDC1 2.89E-01 -BCL10 2.89E-01 -CLSTN1 2.89E-01 -SRP9 2.89E-01 -ASTE1 2.89E-01 -PNP 2.89E-01 -STRBP 2.89E-01 -MRP63 2.89E-01 -C1QTNF2 2.89E-01 -RDH12 2.89E-01 -E2F3 2.89E-01 -TMEM108 2.89E-01 -SNURF 2.90E-01 -CLDN8 2.90E-01 -RHOQ 2.90E-01 -SERPINB1 2.90E-01 -MLX 2.90E-01 -ASF1B 2.90E-01 -GARS 2.90E-01 -MTA3 2.90E-01 -CACNB4 2.90E-01 -GPR149 2.90E-01 -PTBP2 2.90E-01 -TBCB 2.90E-01 -B3GALT1 2.90E-01 -INPP5B 2.90E-01 -ESPL1 2.91E-01 -ZHX3 2.91E-01 -DLX4 2.91E-01 -ALG6 2.91E-01 -MRGPRX1 2.91E-01 -JAKMIP1 2.91E-01 -PFKM 2.91E-01 -DHRSX 2.91E-01 -GUCY2F 2.91E-01 -EPHA3 2.91E-01 -CELA1 2.91E-01 -KRT26 2.91E-01 -TMOD2 2.91E-01 -SLC41A1 2.91E-01 -DAPK1 2.91E-01 -CNP 2.92E-01 -RBM22 2.92E-01 -SERTAD3 2.92E-01 -KRT6C 2.92E-01 -POLR1C 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3.26E-01 -ACCS 3.26E-01 -CCDC85A 3.26E-01 -MBD2 3.26E-01 -LAMC1 3.26E-01 -HSD17B2 3.26E-01 -ARHGAP6 3.26E-01 -BATF3 3.26E-01 -RBPMS 3.26E-01 -TMEM133 3.26E-01 -LLGL1 3.26E-01 -AADAT 3.26E-01 -PGAP2 3.27E-01 -HMGCLL1 3.27E-01 -PPP2R5D 3.27E-01 -LIMD1 3.27E-01 -KLHL10 3.27E-01 -DGKI 3.27E-01 -ACPL2 3.27E-01 -PDE4D 3.27E-01 -PXMP2 3.27E-01 -SLC6A14 3.27E-01 -ATG2A 3.27E-01 -GAS6 3.27E-01 -STX10 3.27E-01 -TMEM39A 3.27E-01 -CYP4F3 3.28E-01 -UNC13C 3.28E-01 -N4BP3 3.28E-01 -KATNA1 3.28E-01 -OPRD1 3.28E-01 -ZNF385A 3.28E-01 -CRLF1 3.28E-01 -BTF3L4 3.28E-01 -HIST1H4D 3.28E-01 -FCHO2 3.28E-01 -TANK 3.28E-01 -RAB3IP 3.28E-01 -PNLDC1 3.28E-01 -AZGP1 3.28E-01 -GNPAT 3.28E-01 -TMEM132D 3.29E-01 -CDH1 3.29E-01 -CXCR4 3.29E-01 -HDAC3 3.29E-01 -RMND5B 3.29E-01 -ETHE1 3.29E-01 -POR 3.29E-01 -PDE8A 3.29E-01 -HARBI1 3.29E-01 -MATN1 3.29E-01 -TMEM161B 3.29E-01 -LRRC42 3.29E-01 -BRD9 3.29E-01 -MPZL1 3.29E-01 -SLC25A1 3.30E-01 -DCTN6 3.30E-01 -CHSY3 3.30E-01 -PTPRF 3.30E-01 -NPL 3.30E-01 -KBTBD6 3.30E-01 -TCF23 3.30E-01 -CNNM4 3.30E-01 -TMEM203 3.30E-01 -EZH1 3.30E-01 -PRPF18 3.30E-01 -FBXO33 3.30E-01 -CFP 3.30E-01 -TOX4 3.30E-01 -BTBD10 3.30E-01 -ALDH5A1 3.31E-01 -CSRNP3 3.31E-01 -TINAG 3.31E-01 -TNFSF10 3.31E-01 -DEFB134 3.31E-01 -PPAPDC3 3.31E-01 -EIF4E2 3.31E-01 -CDR1 3.31E-01 -GNPTG 3.31E-01 -OGFOD2 3.31E-01 -LDHB 3.31E-01 -RNPS1 3.31E-01 -SEZ6L 3.31E-01 -MAP3K13 3.31E-01 -CACNB3 3.32E-01 -GPR132 3.32E-01 -TPM4 3.32E-01 -CNTNAP4 3.32E-01 -EBF2 3.32E-01 -GPR183 3.32E-01 -PCGF2 3.32E-01 -GFPT1 3.32E-01 -GAP43 3.32E-01 -TMCO5A 3.32E-01 -GABRG1 3.32E-01 -RLBP1 3.32E-01 -VPS37B 3.32E-01 -SEPT11 3.32E-01 -GRHPR 3.32E-01 -PTP4A3 3.33E-01 -ZNF689 3.33E-01 -HOXD10 3.33E-01 -CPXM1 3.33E-01 -PARS2 3.33E-01 -CHAF1B 3.33E-01 -HAT1 3.33E-01 -CITED1 3.33E-01 -MOB2 3.33E-01 -RPAP2 3.33E-01 -TAF6L 3.33E-01 -CAMK2N1 3.33E-01 -KCTD10 3.33E-01 -TMPRSS11F 3.33E-01 -PCGF3 3.34E-01 -TMEM179 3.34E-01 -NDUFB8 3.34E-01 -PWWP2A 3.34E-01 -LMBRD2 3.34E-01 -TAF11 3.34E-01 -WSCD1 3.34E-01 -E2F6 3.34E-01 -LRRC8D 3.34E-01 -KCNK13 3.34E-01 -TNFRSF9 3.34E-01 -ELAVL3 3.34E-01 -SCOC 3.34E-01 -MEAF6 3.34E-01 -CAPN12 3.34E-01 -C3 3.35E-01 -PPP1R1B 3.35E-01 -PLXNB2 3.35E-01 -SNX6 3.35E-01 -CYB5R4 3.35E-01 -CAPN7 3.35E-01 -CNPY3 3.35E-01 -SDHC 3.35E-01 -BEST4 3.35E-01 -FAIM3 3.35E-01 -PSMB6 3.35E-01 -DOCK2 3.35E-01 -ABT1 3.35E-01 -LRRC55 3.35E-01 -TMTC2 3.36E-01 -TMEM17 3.36E-01 -IP6K1 3.36E-01 -TBC1D10A 3.36E-01 -PDCD2 3.36E-01 -RAB5B 3.36E-01 -CDC123 3.36E-01 -GADD45B 3.36E-01 -ASCL3 3.36E-01 -FAM46A 3.36E-01 -SART1 3.36E-01 -MLLT10 3.36E-01 -SLC41A2 3.36E-01 -IGSF21 3.36E-01 -STRA13 3.36E-01 -MARCH3 3.37E-01 -CAPN11 3.37E-01 -HIST1H3H 3.37E-01 -FKBP10 3.37E-01 -THBS3 3.37E-01 -WDR92 3.37E-01 -PRKAG1 3.37E-01 -WNT1 3.37E-01 -KDM1A 3.37E-01 -HIST2H2BE 3.37E-01 -PELI1 3.37E-01 -MOCOS 3.37E-01 -FUT9 3.37E-01 -CBX3 3.37E-01 -PYCR2 3.38E-01 -SLC25A37 3.38E-01 -IRAK1BP1 3.38E-01 -ESCO1 3.38E-01 -ZNF202 3.38E-01 -CCR4 3.38E-01 -MAGT1 3.38E-01 -BTBD11 3.38E-01 -MMP16 3.38E-01 -FAM76A 3.38E-01 -DNM3 3.38E-01 -DHRS2 3.38E-01 -ACOXL 3.38E-01 -BCORL1 3.38E-01 -GLRA2 3.38E-01 -CSRP3 3.39E-01 -TSG101 3.39E-01 -STAT4 3.39E-01 -TRPV5 3.39E-01 -FAM196A 3.39E-01 -HIVEP1 3.39E-01 -TTK 3.39E-01 -CCS 3.39E-01 -IGF2R 3.39E-01 -FAM57B 3.39E-01 -HNRNPA1L2 3.39E-01 -AGXT2 3.39E-01 -NCOR2 3.39E-01 -GJC3 3.39E-01 -CLIC4 3.40E-01 -ADM 3.40E-01 -C9orf64 3.40E-01 -TCAP 3.40E-01 -MAGEA4 3.40E-01 -VGLL3 3.40E-01 -CTNNA1 3.40E-01 -TGFB1I1 3.40E-01 -CNGA1 3.40E-01 -DSTYK 3.40E-01 -BCL7B 3.40E-01 -KRT36 3.40E-01 -DNAJB8 3.40E-01 -STMN4 3.40E-01 -FAM172A 3.40E-01 -GADD45A 3.41E-01 -HPS6 3.41E-01 -ID1 3.41E-01 -DHTKD1 3.41E-01 -PLCXD2 3.41E-01 -RASGRP2 3.41E-01 -TMEM30A 3.41E-01 -HAPLN1 3.41E-01 -E2F8 3.41E-01 -CHL1 3.41E-01 -PHPT1 3.41E-01 -STK39 3.41E-01 -DHRS4 3.41E-01 -AKT3 3.41E-01 -HLA-DRA 3.42E-01 -ANAPC5 3.42E-01 -PRKD3 3.42E-01 -LIPH 3.42E-01 -DMD 3.42E-01 -GLRB 3.42E-01 -ETNK2 3.42E-01 -DHRS13 3.42E-01 -TMED10 3.42E-01 -KARS 3.42E-01 -MAN1C1 3.42E-01 -ADCK5 3.42E-01 -CMPK1 3.42E-01 -ZNF32 3.42E-01 -UBA1 3.42E-01 -C9orf41 3.43E-01 -NOP10 3.43E-01 -PEX19 3.43E-01 -GTF2F2 3.43E-01 -ARID1B 3.43E-01 -TSPAN4 3.43E-01 -MRPS22 3.43E-01 -KLK14 3.43E-01 -GMPPA 3.43E-01 -ING1 3.43E-01 -PTH2 3.43E-01 -HM13 3.43E-01 -MPL 3.43E-01 -PTPN4 3.43E-01 -CELF4 3.44E-01 -TMPRSS13 3.44E-01 -C5orf49 3.44E-01 -ACADL 3.44E-01 -ATP8B4 3.44E-01 -SRMS 3.44E-01 -INO80E 3.44E-01 -CINP 3.44E-01 -ACMSD 3.44E-01 -PABPC1L 3.44E-01 -UBXN4 3.44E-01 -CH25H 3.44E-01 -MKX 3.44E-01 -ZNF121 3.44E-01 -CRYAB 3.44E-01 -FAR1 3.45E-01 -RB1CC1 3.45E-01 -GLI2 3.45E-01 -ASB1 3.45E-01 -COX17 3.45E-01 -HERPUD2 3.45E-01 -C6orf223 3.45E-01 -SLC2A3 3.45E-01 -WTAP 3.45E-01 -NCLN 3.45E-01 -STEAP2 3.45E-01 -CHUK 3.45E-01 -MED12L 3.45E-01 -MRGPRF 3.45E-01 -FMR1NB 3.46E-01 -UNC119 3.46E-01 -IL5 3.46E-01 -CELA3A 3.46E-01 -PLRG1 3.46E-01 -NOL8 3.46E-01 -ZNF81 3.46E-01 -PDCL 3.46E-01 -SLC35F2 3.46E-01 -OPN5 3.46E-01 -REPS2 3.46E-01 -CMTM7 3.46E-01 -TERF2 3.46E-01 -MIER2 3.46E-01 -DMGDH 3.46E-01 -RGS7 3.47E-01 -C11orf48 3.47E-01 -SPANXN3 3.47E-01 -TRNAU1AP 3.47E-01 -SLC7A6OS 3.47E-01 -NPAS3 3.47E-01 -HADHA 3.47E-01 -CMTM6 3.47E-01 -SPDYA 3.47E-01 -KAL1 3.47E-01 -FAM120C 3.47E-01 -CCDC64 3.47E-01 -HEXIM2 3.47E-01 -FTMT 3.47E-01 -THAP1 3.48E-01 -GK2 3.48E-01 -RBM39 3.48E-01 -CSNK1E 3.48E-01 -BEST2 3.48E-01 -TBXA2R 3.48E-01 -LDHAL6B 3.48E-01 -PACRG 3.48E-01 -ATG4D 3.48E-01 -HCFC2 3.48E-01 -UBE2I 3.48E-01 -BMI1 3.48E-01 -HPR 3.48E-01 -C10orf111 3.48E-01 -MRAP 3.48E-01 -TGFBRAP1 3.49E-01 -CHMP5 3.49E-01 -HAUS7 3.49E-01 -HIVEP3 3.49E-01 -CKAP5 3.49E-01 -CDC42EP4 3.49E-01 -MED22 3.49E-01 -CPNE2 3.49E-01 -SCG2 3.49E-01 -GNAT1 3.49E-01 -PPP1R15B 3.49E-01 -CDC42EP2 3.49E-01 -C8orf58 3.49E-01 -ROCK1 3.49E-01 -TIPARP 3.50E-01 -ATF2 3.50E-01 -BRD1 3.50E-01 -TICAM1 3.50E-01 -ARHGDIB 3.50E-01 -IQSEC3 3.50E-01 -ZFYVE27 3.50E-01 -ELMOD1 3.50E-01 -ERGIC1 3.50E-01 -WBP2 3.50E-01 -PTPN12 3.50E-01 -PIKFYVE 3.50E-01 -CERCAM 3.50E-01 -UCK1 3.50E-01 -KRTAP20-2 3.50E-01 -TRPV6 3.51E-01 -CYP1B1 3.51E-01 -CNTN1 3.51E-01 -OVOL1 3.51E-01 -RIT1 3.51E-01 -CRY1 3.51E-01 -ST3GAL1 3.51E-01 -SMPDL3A 3.51E-01 -TNNC2 3.51E-01 -ZIC4 3.51E-01 -GTF3C6 3.51E-01 -MEIS1 3.51E-01 -ARID4A 3.51E-01 -STAR 3.51E-01 -CNR1 3.51E-01 -CALN1 3.52E-01 -ARID3A 3.52E-01 -CUEDC2 3.52E-01 -DPP10 3.52E-01 -TMEM41A 3.52E-01 -SAFB2 3.52E-01 -FAM96B 3.52E-01 -PHF2 3.52E-01 -SSNA1 3.52E-01 -PHF8 3.52E-01 -CHRNA2 3.52E-01 -BARX2 3.52E-01 -KCNK1 3.52E-01 -MRAP2 3.52E-01 -CHRNA6 3.53E-01 -CDH9 3.53E-01 -FAM60A 3.53E-01 -GAN 3.53E-01 -CCL19 3.53E-01 -TMEM187 3.53E-01 -GRAMD1B 3.53E-01 -LCE3A 3.53E-01 -PDCD5 3.53E-01 -PARD6A 3.53E-01 -RAB40C 3.53E-01 -GDF15 3.53E-01 -FSHB 3.53E-01 -CISH 3.53E-01 -RAB13 3.53E-01 -TIA1 3.54E-01 -SLC25A22 3.54E-01 -SLC18A2 3.54E-01 -TPH1 3.54E-01 -NCOA6 3.54E-01 -STIP1 3.54E-01 -FBXW11 3.54E-01 -ARPP21 3.54E-01 -RABIF 3.54E-01 -B3GNT7 3.54E-01 -CYB5A 3.54E-01 -TMEM56 3.54E-01 -IRS1 3.54E-01 -EPO 3.54E-01 -MYCBP 3.55E-01 -PHYHIPL 3.55E-01 -SEC24A 3.55E-01 -NAA40 3.55E-01 -NRBF2 3.55E-01 -AASS 3.55E-01 -TNRC6C 3.55E-01 -KCTD8 3.55E-01 -GIT1 3.55E-01 -NEK8 3.55E-01 -STARD5 3.55E-01 -ASAP2 3.55E-01 -MRFAP1L1 3.55E-01 -HELT 3.55E-01 -RABL5 3.55E-01 -TPRG1 3.56E-01 -COX6A1 3.56E-01 -CHEK2 3.56E-01 -HIST4H4 3.56E-01 -FGA 3.56E-01 -SLC39A8 3.56E-01 -GPD2 3.56E-01 -MTNR1B 3.56E-01 -ZCCHC12 3.56E-01 -WSB2 3.56E-01 -STOML1 3.56E-01 -B3GALT5 3.56E-01 -WARS2 3.56E-01 -DIP2C 3.56E-01 -SAMD8 3.57E-01 -ARL3 3.57E-01 -BLOC1S2 3.57E-01 -TMEM132B 3.57E-01 -LGI2 3.57E-01 -KANK2 3.57E-01 -CDH18 3.57E-01 -AKT1 3.57E-01 -TBC1D25 3.57E-01 -SREBF2 3.57E-01 -RHOH 3.57E-01 -CCDC126 3.57E-01 -URGCP 3.57E-01 -PUF60 3.57E-01 -DNAJC2 3.57E-01 -FAM171B 3.58E-01 -UCP3 3.58E-01 -GZMH 3.58E-01 -THAP11 3.58E-01 -USP5 3.58E-01 -GPC1 3.58E-01 -ATP6V0E1 3.58E-01 -CFH 3.58E-01 -CDC25A 3.58E-01 -DDX21 3.58E-01 -TMUB1 3.58E-01 -LNPEP 3.58E-01 -C17orf64 3.58E-01 -PCSK7 3.58E-01 -FOXR1 3.59E-01 -SAMD10 3.59E-01 -HEXDC 3.59E-01 -APOA2 3.59E-01 -RAE1 3.59E-01 -LPIN1 3.59E-01 -NR0B2 3.59E-01 -ELF4 3.59E-01 -KRTAP1-3 3.59E-01 -C14orf142 3.59E-01 -TPPP 3.59E-01 -SLC25A3 3.59E-01 -RPE 3.59E-01 -SHARPIN 3.59E-01 -ABCG5 3.59E-01 -EDNRB 3.60E-01 -RHOU 3.60E-01 -SAMD12 3.60E-01 -ARMC1 3.60E-01 -ARFIP2 3.60E-01 -MRPL15 3.60E-01 -L2HGDH 3.60E-01 -TEX14 3.60E-01 -SULT1C2 3.60E-01 -TPST1 3.60E-01 -HTT 3.60E-01 -IQCJ 3.60E-01 -MRPS6 3.60E-01 -NDST2 3.60E-01 -ITGB1BP1 3.61E-01 -CD27 3.61E-01 -BSX 3.61E-01 -PGS1 3.61E-01 -HHIP 3.61E-01 -PLXNA1 3.61E-01 -TPR 3.61E-01 -CCT2 3.61E-01 -ANKRD13B 3.61E-01 -ASNA1 3.61E-01 -UBE2M 3.61E-01 -DSG1 3.61E-01 -C15orf38 3.61E-01 -PEF1 3.61E-01 -ELOF1 3.61E-01 -HMGN1 3.62E-01 -C16orf45 3.62E-01 -KCTD15 3.62E-01 -PNOC 3.62E-01 -CTGF 3.62E-01 -NBEA 3.62E-01 -SIAH3 3.62E-01 -NIPAL1 3.62E-01 -ZYG11B 3.62E-01 -SLC35A1 3.62E-01 -UBAC1 3.62E-01 -SH3BGRL 3.62E-01 -SLC8A1 3.62E-01 -EVI2A 3.62E-01 -ANK2 3.63E-01 -SLC34A1 3.63E-01 -BBOX1 3.63E-01 -KCNE2 3.63E-01 -INPP5J 3.63E-01 -MAGEA6 3.63E-01 -SATB1 3.63E-01 -ASTN2 3.63E-01 -PTGER2 3.63E-01 -SSTR1 3.63E-01 -EGFL7 3.63E-01 -SCN4B 3.63E-01 -C9orf89 3.63E-01 -BRD4 3.63E-01 -PPP4R1 3.63E-01 -BAP1 3.64E-01 -CAPN13 3.64E-01 -LDLRAD1 3.64E-01 -HOXB13 3.64E-01 -RNASE1 3.64E-01 -DRAM1 3.64E-01 -PRKAB1 3.64E-01 -F2R 3.64E-01 -EIF2B1 3.64E-01 -BTBD7 3.64E-01 -GGA1 3.64E-01 -CLSTN3 3.64E-01 -BAI3 3.64E-01 -UQCRC1 3.64E-01 -ZNF282 3.65E-01 -FEM1C 3.65E-01 -ICA1L 3.65E-01 -ZPLD1 3.65E-01 -NCOA5 3.65E-01 -FSTL4 3.65E-01 -ADSS 3.65E-01 -RBMS1 3.65E-01 -SPTBN4 3.65E-01 -PRRG3 3.65E-01 -FTCD 3.65E-01 -ARL6IP6 3.65E-01 -APOO 3.65E-01 -HECTD1 3.65E-01 -GJA9 3.65E-01 -CDK14 3.66E-01 -FAM45A 3.66E-01 -PAGE1 3.66E-01 -LUM 3.66E-01 -WWP2 3.66E-01 -RAPH1 3.66E-01 -HMGN3 3.66E-01 -PKD2 3.66E-01 -SMC1B 3.66E-01 -EMP1 3.66E-01 -PTPRU 3.66E-01 -MAP2K6 3.66E-01 -ST13 3.66E-01 -UBE2Q2 3.66E-01 -EEF1B2 3.67E-01 -IL23R 3.67E-01 -MUM1L1 3.67E-01 -SFTPD 3.67E-01 -SLC6A11 3.67E-01 -DGKQ 3.67E-01 -C12orf5 3.67E-01 -CLCF1 3.67E-01 -MAP1A 3.67E-01 -MYF5 3.67E-01 -KIN 3.67E-01 -FOXR2 3.67E-01 -CYB5R1 3.67E-01 -TMEM206 3.67E-01 -UBASH3B 3.67E-01 -GABRR1 3.68E-01 -NOXA1 3.68E-01 -QTRTD1 3.68E-01 -ZNF691 3.68E-01 -ZNF649 3.68E-01 -MDH2 3.68E-01 -MYO1H 3.68E-01 -ZNF750 3.68E-01 -FLI1 3.68E-01 -GREM2 3.68E-01 -TAF9 3.68E-01 -CSPG5 3.68E-01 -DTYMK 3.68E-01 -ZNF655 3.68E-01 -PPEF1 3.69E-01 -RASSF7 3.69E-01 -ARID3B 3.69E-01 -C7orf41 3.69E-01 -NUDCD3 3.69E-01 -NRIP2 3.69E-01 -GPBP1L1 3.69E-01 -GLS 3.69E-01 -OR51A2 3.69E-01 -NDUFB10 3.69E-01 -CNKSR2 3.69E-01 -RRP9 3.69E-01 -TRIM11 3.69E-01 -SMYD2 3.69E-01 -PSMD14 3.69E-01 -SHE 3.70E-01 -GALNT9 3.70E-01 -SNX2 3.70E-01 -RNF114 3.70E-01 -ADCY4 3.70E-01 -CFB 3.70E-01 -TNFRSF6B 3.70E-01 -PLEKHG3 3.70E-01 -C9orf135 3.70E-01 -UBB 3.70E-01 -PPP1R14B 3.70E-01 -CDK16 3.70E-01 -KRTDAP 3.70E-01 -PNLIPRP3 3.70E-01 -VAT1 3.71E-01 -MED27 3.71E-01 -EXOC3 3.71E-01 -C19orf73 3.71E-01 -ARHGEF11 3.71E-01 -NKG7 3.71E-01 -MC2R 3.71E-01 -HEXB 3.71E-01 -IFT20 3.71E-01 -SLC2A6 3.71E-01 -CDC16 3.71E-01 -MPRIP 3.71E-01 -GPR176 3.71E-01 -VPS37C 3.71E-01 -UQCRQ 3.71E-01 -ARHGEF15 3.72E-01 -C9 3.72E-01 -CBR1 3.72E-01 -ATAD5 3.72E-01 -KPNA2 3.72E-01 -PTRF 3.72E-01 -DNAJC13 3.72E-01 -BFSP1 3.72E-01 -PEX14 3.72E-01 -GNA14 3.72E-01 -TXNL1 3.72E-01 -CD97 3.72E-01 -UBAC2 3.72E-01 -FAM134A 3.72E-01 -CCDC134 3.73E-01 -SLC25A46 3.73E-01 -FOSB 3.73E-01 -SFN 3.73E-01 -FZD3 3.73E-01 -NAV2 3.73E-01 -NEU3 3.73E-01 -OC90 3.73E-01 -SUMO3 3.73E-01 -HSD17B6 3.73E-01 -CMTM3 3.73E-01 -LEP 3.73E-01 -NTHL1 3.73E-01 -POLR2F 3.73E-01 -TSLP 3.73E-01 -BECN1 3.74E-01 -EIF1B 3.74E-01 -STX8 3.74E-01 -ATP8A2 3.74E-01 -RNF219 3.74E-01 -SYCP3 3.74E-01 -PALM2 3.74E-01 -OLR1 3.74E-01 -CHMP6 3.74E-01 -ATXN2 3.74E-01 -NPEPPS 3.74E-01 -GUCY2C 3.74E-01 -HNRNPM 3.74E-01 -ITGAL 3.74E-01 -IL17REL 3.75E-01 -PRKCZ 3.75E-01 -PUM2 3.75E-01 -ARHGAP32 3.75E-01 -DUSP4 3.75E-01 -DUSP5 3.75E-01 -SBDS 3.75E-01 -SNCB 3.75E-01 -FSD1 3.75E-01 -FNDC3A 3.75E-01 -CD52 3.75E-01 -LHB 3.75E-01 -TINAGL1 3.75E-01 -B3GAT1 3.75E-01 -IL1RN 3.75E-01 -ZNF280B 3.76E-01 -MTAP 3.76E-01 -PDE1A 3.76E-01 -CHMP2A 3.76E-01 -MARVELD3 3.76E-01 -RABGAP1L 3.76E-01 -C6orf89 3.76E-01 -GM2A 3.76E-01 -SCYL2 3.76E-01 -GOLPH3L 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3.85E-01 -RIC3 3.85E-01 -ZNF830 3.85E-01 -SMC4 3.85E-01 -CRYM 3.85E-01 -PASD1 3.85E-01 -C12orf68 3.85E-01 -ZSCAN18 3.85E-01 -API5 3.85E-01 -CELSR3 3.85E-01 -DERL2 3.85E-01 -PDSS1 3.85E-01 -S100A10 3.85E-01 -ITIH1 3.85E-01 -KLHL17 3.86E-01 -RBM7 3.86E-01 -ZNF746 3.86E-01 -CDADC1 3.86E-01 -SNTA1 3.86E-01 -EDA2R 3.86E-01 -WNT8B 3.86E-01 -MAGEB18 3.86E-01 -CDH6 3.86E-01 -CD82 3.86E-01 -GTSF1 3.86E-01 -LRRN1 3.86E-01 -SYNJ2BP 3.86E-01 -SH3PXD2A 3.86E-01 -SFMBT2 3.86E-01 -TDO2 3.87E-01 -ELMO1 3.87E-01 -EXTL2 3.87E-01 -TMEM217 3.87E-01 -SSTR2 3.87E-01 -SLC9A1 3.87E-01 -OR2AE1 3.87E-01 -GPIHBP1 3.87E-01 -GPR137C 3.87E-01 -DDOST 3.87E-01 -RIPK1 3.87E-01 -MANBAL 3.87E-01 -DDO 3.87E-01 -LRRC3B 3.87E-01 -SLC8A3 3.88E-01 -SREBF1 3.88E-01 -ZFP90 3.88E-01 -HGSNAT 3.88E-01 -PRKX 3.88E-01 -C12orf4 3.88E-01 -C11orf84 3.88E-01 -CNIH3 3.88E-01 -RIBC1 3.88E-01 -BCL2L2 3.88E-01 -C14orf183 3.88E-01 -PSMA4 3.88E-01 -MLLT4 3.88E-01 -RHO 3.88E-01 -SAP18 3.88E-01 -UBQLN3 3.89E-01 -SORT1 3.89E-01 -CHTF8 3.89E-01 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3.93E-01 -HSPE1 3.93E-01 -ABTB2 3.93E-01 -AHR 3.93E-01 -SV2A 3.93E-01 -FXYD1 3.93E-01 -FAM120A 3.93E-01 -CHAC1 3.93E-01 -DENND2A 3.94E-01 -PRPH 3.94E-01 -NDUFA3 3.94E-01 -CD7 3.94E-01 -FIS1 3.94E-01 -FAM126B 3.94E-01 -PDE1B 3.94E-01 -PROCR 3.94E-01 -ISOC1 3.94E-01 -LSM4 3.94E-01 -PPY 3.94E-01 -C5orf46 3.94E-01 -PSD 3.94E-01 -EDARADD 3.94E-01 -CCDC117 3.94E-01 -RASL11A 3.95E-01 -PHC1 3.95E-01 -RAB21 3.95E-01 -FEZF1 3.95E-01 -ZNF326 3.95E-01 -STAU2 3.95E-01 -FLOT2 3.95E-01 -MAD2L2 3.95E-01 -ZFP1 3.95E-01 -DENND5A 3.95E-01 -CALB2 3.95E-01 -HTATSF1 3.95E-01 -FAM136A 3.95E-01 -ARFGEF2 3.95E-01 -ADRB2 3.96E-01 -ANKS1A 3.96E-01 -LIN7B 3.96E-01 -RGN 3.96E-01 -HMGB4 3.96E-01 -CNDP2 3.96E-01 -BAG4 3.96E-01 -SSTR3 3.96E-01 -CAMTA2 3.96E-01 -S1PR3 3.96E-01 -WDR16 3.96E-01 -LGR5 3.96E-01 -FCHO1 3.96E-01 -PJA1 3.96E-01 -ACTR8 3.96E-01 -WFDC2 3.97E-01 -WBP4 3.97E-01 -PICK1 3.97E-01 -HOXB8 3.97E-01 -STAC2 3.97E-01 -MAT2B 3.97E-01 -C10orf54 3.97E-01 -DKK1 3.97E-01 -ZBTB45 3.97E-01 -ISY1 3.97E-01 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5.64E-01 -AKAP10 5.64E-01 -WASF3 5.64E-01 -CHURC1 5.64E-01 -IL24 5.64E-01 -ZMPSTE24 5.64E-01 -AMBP 5.64E-01 -RFPL4B 5.64E-01 -HSD17B8 5.64E-01 -SCMH1 5.64E-01 -ZNF248 5.64E-01 -HIST1H4C 5.65E-01 -NDUFB5 5.65E-01 -TBL2 5.65E-01 -EPHA1 5.65E-01 -TACO1 5.65E-01 -HYLS1 5.65E-01 -OGN 5.65E-01 -SCNN1G 5.65E-01 -TTC5 5.65E-01 -SH2D1B 5.65E-01 -TESK2 5.65E-01 -GFOD2 5.65E-01 -VPS33A 5.65E-01 -TRHDE 5.65E-01 -GFRA1 5.65E-01 -ZBTB48 5.66E-01 -DECR2 5.66E-01 -GALNT2 5.66E-01 -LCN12 5.66E-01 -RGR 5.66E-01 -POLR1B 5.66E-01 -SAMSN1 5.66E-01 -ATN1 5.66E-01 -SLC29A4 5.66E-01 -PNMA1 5.66E-01 -FTSJ2 5.66E-01 -NEDD4L 5.66E-01 -ARAP3 5.66E-01 -GRIP1 5.66E-01 -C20orf166 5.67E-01 -ZMAT5 5.67E-01 -GPN2 5.67E-01 -LARS2 5.67E-01 -LPAR2 5.67E-01 -PFKP 5.67E-01 -MAP3K5 5.67E-01 -ST8SIA1 5.67E-01 -NDST3 5.67E-01 -HSP90AA1 5.67E-01 -PAK1IP1 5.67E-01 -OR2B6 5.67E-01 -SLC6A9 5.67E-01 -AIDA 5.67E-01 -RFFL 5.67E-01 -TSPAN6 5.68E-01 -MYOZ2 5.68E-01 -DCDC1 5.68E-01 -C4orf26 5.68E-01 -CPNE8 5.68E-01 -CCL24 5.68E-01 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5.72E-01 -OR1A2 5.72E-01 -DNAJC8 5.72E-01 -NXF3 5.72E-01 -UPK3A 5.72E-01 -HIBADH 5.72E-01 -FCN2 5.73E-01 -NDUFS5 5.73E-01 -RNF181 5.73E-01 -OR1G1 5.73E-01 -C5orf51 5.73E-01 -TRIM60 5.73E-01 -ADAM2 5.73E-01 -CCNB1 5.73E-01 -TBP 5.73E-01 -PNMA3 5.73E-01 -LARP1 5.73E-01 -CTSZ 5.73E-01 -PTPRH 5.73E-01 -GPR15 5.73E-01 -SVIL 5.73E-01 -PGPEP1 5.74E-01 -FAM65A 5.74E-01 -SLC25A17 5.74E-01 -ALDH1B1 5.74E-01 -ERBB2IP 5.74E-01 -GPR160 5.74E-01 -DUSP18 5.74E-01 -CHST14 5.74E-01 -ZPBP 5.74E-01 -CASP2 5.74E-01 -PCBD1 5.74E-01 -NPHS1 5.74E-01 -SIAH1 5.74E-01 -B9D2 5.74E-01 -NMUR1 5.75E-01 -INPP4B 5.75E-01 -DDIT3 5.75E-01 -HINT1 5.75E-01 -PRKAA1 5.75E-01 -GALNTL6 5.75E-01 -CAMK2B 5.75E-01 -SPHKAP 5.75E-01 -NAGPA 5.75E-01 -PDK2 5.75E-01 -HDDC3 5.75E-01 -CLDN25 5.75E-01 -ARRB2 5.75E-01 -LY6G6C 5.75E-01 -S100A11 5.75E-01 -HIST1H4E 5.76E-01 -SPC25 5.76E-01 -CIZ1 5.76E-01 -CRIP1 5.76E-01 -ATG4C 5.76E-01 -BIN1 5.76E-01 -LIAS 5.76E-01 -CCDC121 5.76E-01 -FAM167A 5.76E-01 -C2orf70 5.76E-01 -ANAPC13 5.76E-01 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7.59E-01 -SEPT9 7.59E-01 -ST6GALNAC2 7.59E-01 -CA6 7.59E-01 -FBXW5 7.59E-01 -COMMD6 7.59E-01 -FAM107A 7.59E-01 -PLEKHA3 7.59E-01 -GPR108 7.59E-01 -ZNF324B 7.59E-01 -ZNF567 7.59E-01 -AP1AR 7.60E-01 -TMEM155 7.60E-01 -CREM 7.60E-01 -ZC3HC1 7.60E-01 -EFCAB3 7.60E-01 -KIAA0319L 7.60E-01 -USP35 7.60E-01 -TMPO 7.60E-01 -TLL2 7.60E-01 -OR52E2 7.60E-01 -OR5B2 7.60E-01 -SGSM2 7.60E-01 -KRTAP24-1 7.60E-01 -FABP12 7.60E-01 -BRD7 7.61E-01 -APOL2 7.61E-01 -DSE 7.61E-01 -ADRA2B 7.61E-01 -POLR3A 7.61E-01 -LY6D 7.61E-01 -EML4 7.61E-01 -GAL 7.61E-01 -FBXO15 7.61E-01 -FASTKD5 7.61E-01 -ZNF571 7.61E-01 -HERPUD1 7.61E-01 -ZNF707 7.61E-01 -GML 7.61E-01 -TAAR5 7.61E-01 -UBL7 7.62E-01 -NDUFAF2 7.62E-01 -ZNF620 7.62E-01 -SEC14L3 7.62E-01 -DNAJC5G 7.62E-01 -DPPA2 7.62E-01 -CKAP2L 7.62E-01 -SLC28A2 7.62E-01 -GABARAPL2 7.62E-01 -DPCD 7.62E-01 -XAGE5 7.62E-01 -ST3GAL6 7.62E-01 -C8orf31 7.62E-01 -FAM162A 7.62E-01 -CD302 7.63E-01 -HLA-DOA 7.63E-01 -STAM2 7.63E-01 -C8orf44 7.63E-01 -USP28 7.63E-01 -AFAP1L1 7.63E-01 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7.84E-01 -MYEOV 7.84E-01 -BIK 7.84E-01 -NUDT6 7.84E-01 -DHX33 7.84E-01 -UAP1L1 7.84E-01 -WDR59 7.84E-01 -SELPLG 7.84E-01 -C1orf105 7.84E-01 -OR52B2 7.84E-01 -EIF4E3 7.84E-01 -FAM98C 7.84E-01 -ZNF880 7.84E-01 -C17orf74 7.84E-01 -HORMAD2 7.85E-01 -ANKRD45 7.85E-01 -RWDD3 7.85E-01 -DNAJC27 7.85E-01 -PI16 7.85E-01 -KRTAP6-1 7.85E-01 -CYP2A13 7.85E-01 -CLEC9A 7.85E-01 -TMTC1 7.85E-01 -MERTK 7.85E-01 -KIF14 7.85E-01 -TMCC3 7.85E-01 -STK17A 7.85E-01 -LCMT1 7.85E-01 -STX18 7.86E-01 -TSPO2 7.86E-01 -HIRIP3 7.86E-01 -CCT8L2 7.86E-01 -SLC39A2 7.86E-01 -HPX 7.86E-01 -SFXN2 7.86E-01 -TRAF3IP3 7.86E-01 -CPA5 7.86E-01 -GLI1 7.86E-01 -RUFY1 7.86E-01 -KIF7 7.86E-01 -OSBPL10 7.86E-01 -CSF3R 7.86E-01 -ASB10 7.86E-01 -NDRG4 7.87E-01 -SEMA4D 7.87E-01 -PON1 7.87E-01 -MRPS28 7.87E-01 -MYOZ3 7.87E-01 -LCE3E 7.87E-01 -RBM11 7.87E-01 -SEC31A 7.87E-01 -AADACL4 7.87E-01 -CWF19L2 7.87E-01 -OR4D5 7.87E-01 -ZNF157 7.87E-01 -RMI1 7.87E-01 -HS1BP3 7.87E-01 -TM6SF2 7.88E-01 -OR8D4 7.88E-01 -TNIP2 7.88E-01 -TRIM16L 7.88E-01 -ITGA10 7.88E-01 -RSPH1 7.88E-01 -AP4M1 7.88E-01 -NMS 7.88E-01 -AURKAIP1 7.88E-01 -UBE2U 7.88E-01 -MORN1 7.88E-01 -BANF2 7.88E-01 -PINK1 7.88E-01 -VIPR1 7.88E-01 -KRR1 7.88E-01 -RAB28 7.89E-01 -C2orf61 7.89E-01 -SPNS3 7.89E-01 -NDC80 7.89E-01 -HORMAD1 7.89E-01 -C2orf44 7.89E-01 -OTUD3 7.89E-01 -IARS2 7.89E-01 -OR4M2 7.89E-01 -CMTM5 7.89E-01 -OR5V1 7.89E-01 -ENAM 7.89E-01 -CCDC153 7.89E-01 -PIWIL4 7.89E-01 -C12orf50 7.90E-01 -GNB5 7.90E-01 -HCLS1 7.90E-01 -PGM2 7.90E-01 -C11orf49 7.90E-01 -TYW3 7.90E-01 -PDIA5 7.90E-01 -SNX7 7.90E-01 -COMMD7 7.90E-01 -MTHFD1 7.90E-01 -SYT5 7.90E-01 -LRRC49 7.90E-01 -SMUG1 7.90E-01 -HSPBAP1 7.90E-01 -NME7 7.90E-01 -SHKBP1 7.91E-01 -C15orf60 7.91E-01 -MCCD1 7.91E-01 -CHRDL2 7.91E-01 -LCN6 7.91E-01 -IFNA13 7.91E-01 -CDKL1 7.91E-01 -ZNF429 7.91E-01 -CNTF 7.91E-01 -FTL 7.91E-01 -TM7SF3 7.91E-01 -LRTM1 7.91E-01 -TACR3 7.91E-01 -PCDH12 7.91E-01 -FBXO4 7.92E-01 -LRPPRC 7.92E-01 -C2orf40 7.92E-01 -GPX8 7.92E-01 -C20orf85 7.92E-01 -CD68 7.92E-01 -MRPL35 7.92E-01 -TRMT5 7.92E-01 -LY86 7.92E-01 -SGSM3 7.92E-01 -APOBEC3D 7.92E-01 -CSN3 7.92E-01 -TFCP2 7.92E-01 -NOL11 7.92E-01 -NMRAL1 7.92E-01 -NUP210 7.93E-01 -PHOSPHO2 7.93E-01 -GRB7 7.93E-01 -SLCO1B3 7.93E-01 -AMDHD1 7.93E-01 -NFX1 7.93E-01 -C3orf33 7.93E-01 -ANKFN1 7.93E-01 -TMEM79 7.93E-01 -SLC38A11 7.93E-01 -RAB5C 7.93E-01 -ATRIP 7.93E-01 -FAM83C 7.93E-01 -MS4A2 7.93E-01 -ARHGAP15 7.94E-01 -SYNPO2L 7.94E-01 -SCFD2 7.94E-01 -ACOT12 7.94E-01 -DTX3L 7.94E-01 -LIFR 7.94E-01 -IFNA17 7.94E-01 -ACOT6 7.94E-01 -IP6K2 7.94E-01 -CARS 7.94E-01 -PSTPIP1 7.94E-01 -PGM3 7.94E-01 -DMP1 7.94E-01 -SNX25 7.94E-01 -DDC 7.94E-01 -C3orf62 7.95E-01 -FABP5 7.95E-01 -ST6GAL2 7.95E-01 -SPHK2 7.95E-01 -ZNF420 7.95E-01 -C1orf111 7.95E-01 -CA1 7.95E-01 -GPR141 7.95E-01 -OR1E1 7.95E-01 -TMX4 7.95E-01 -C1orf210 7.95E-01 -TAS2R3 7.95E-01 -FRZB 7.95E-01 -ACPP 7.95E-01 -NIF3L1 7.96E-01 -NBR1 7.96E-01 -FNDC8 7.96E-01 -TREML4 7.96E-01 -FBXO47 7.96E-01 -FUZ 7.96E-01 -LRRC31 7.96E-01 -TAS2R4 7.96E-01 -LYPD3 7.96E-01 -VIL1 7.96E-01 -EIF2AK1 7.96E-01 -C4orf22 7.96E-01 -OR51G1 7.96E-01 -KRTAP27-1 7.96E-01 -ULBP1 7.96E-01 -MVP 7.97E-01 -IDE 7.97E-01 -TBC1D23 7.97E-01 -OR2H1 7.97E-01 -PPIC 7.97E-01 -CYP4Z1 7.97E-01 -FAM118B 7.97E-01 -C11orf1 7.97E-01 -PLEKHH1 7.97E-01 -QRSL1 7.97E-01 -ROPN1L 7.97E-01 -TRPM7 7.97E-01 -ZNF175 7.97E-01 -TRPM2 7.97E-01 -SIGLEC9 7.98E-01 -ZNF14 7.98E-01 -LMBR1 7.98E-01 -KHNYN 7.98E-01 -C16orf3 7.98E-01 -RNF25 7.98E-01 -LY6G6F 7.98E-01 -NAA20 7.98E-01 -ZNF132 7.98E-01 -TMEM209 7.98E-01 -SHISA3 7.98E-01 -CDH19 7.98E-01 -LSS 7.98E-01 -PDK1 7.98E-01 -SLC30A9 7.98E-01 -CSGALNACT1 7.99E-01 -LIPK 7.99E-01 -ARHGEF10 7.99E-01 -CDHR2 7.99E-01 -TBCD 7.99E-01 -KIF18A 7.99E-01 -KRTAP5-1 7.99E-01 -PNPLA5 7.99E-01 -PTTG2 7.99E-01 -OR2B3 7.99E-01 -OPTC 7.99E-01 -THEM5 7.99E-01 -ME3 7.99E-01 -OR14J1 7.99E-01 -MRPS30 8.00E-01 -PADI2 8.00E-01 -KIF22 8.00E-01 -OR6X1 8.00E-01 -SLMO1 8.00E-01 -TIPIN 8.00E-01 -C9orf129 8.00E-01 -KRTAP1-1 8.00E-01 -TMEM175 8.00E-01 -CTAG2 8.00E-01 -TOR1AIP1 8.00E-01 -C12orf52 8.00E-01 -DYDC2 8.00E-01 -GYS1 8.00E-01 -LSP1 8.00E-01 -PI15 8.01E-01 -PLCD4 8.01E-01 -KLRK1 8.01E-01 -AUH 8.01E-01 -ATXN3L 8.01E-01 -CENPE 8.01E-01 -LYPD5 8.01E-01 -DEPDC4 8.01E-01 -STRADA 8.01E-01 -ZKSCAN5 8.01E-01 -FBXO40 8.01E-01 -OR13D1 8.01E-01 -PDK4 8.01E-01 -PHLDB2 8.01E-01 -TRIM40 8.02E-01 -ETV7 8.02E-01 -CRTAM 8.02E-01 -ODF4 8.02E-01 -DDIT4L 8.02E-01 -DBH 8.02E-01 -LIMCH1 8.02E-01 -SLC38A10 8.02E-01 -PLCE1 8.02E-01 -SUSD5 8.02E-01 -KIAA1324L 8.02E-01 -ZNF584 8.02E-01 -LUZP4 8.02E-01 -REG1B 8.02E-01 -PNMA5 8.02E-01 -HIP1R 8.03E-01 -RHOT2 8.03E-01 -PRAMEF12 8.03E-01 -DFNB59 8.03E-01 -CDC20 8.03E-01 -PLEKHG5 8.03E-01 -CST7 8.03E-01 -KLRB1 8.03E-01 -ACSL6 8.03E-01 -TRUB1 8.03E-01 -EDEM3 8.03E-01 -PGM1 8.03E-01 -WDR6 8.03E-01 -ZNF782 8.03E-01 -FAM133B 8.04E-01 -LPO 8.04E-01 -PCDHA5 8.04E-01 -TTLL1 8.04E-01 -OR2B2 8.04E-01 -UBASH3A 8.04E-01 -IFNA10 8.04E-01 -PSTK 8.04E-01 -MFSD1 8.04E-01 -CLPB 8.04E-01 -SYF2 8.04E-01 -OR6C4 8.04E-01 -ZNF667 8.04E-01 -C15orf57 8.04E-01 -OR7D4 8.04E-01 -PIGZ 8.05E-01 -OR5P2 8.05E-01 -OR51I1 8.05E-01 -PCDHA6 8.05E-01 -LMBR1L 8.05E-01 -SEPT12 8.05E-01 -ZNF92 8.05E-01 -ANKLE2 8.05E-01 -ETV2 8.05E-01 -OR8B3 8.05E-01 -TMEM177 8.05E-01 -CYSLTR2 8.05E-01 -RTN4 8.05E-01 -ALPK3 8.05E-01 -BEND7 8.06E-01 -TAAR2 8.06E-01 -COMMD10 8.06E-01 -WDFY2 8.06E-01 -FRAS1 8.06E-01 -DNAJC9 8.06E-01 -RILPL1 8.06E-01 -NUMB 8.06E-01 -OCEL1 8.06E-01 -ERI1 8.06E-01 -OR8D1 8.06E-01 -OR6C76 8.06E-01 -ARMC6 8.06E-01 -PLIN3 8.06E-01 -SPTA1 8.06E-01 -MMP17 8.07E-01 -OR5T2 8.07E-01 -COX4I2 8.07E-01 -CCDC122 8.07E-01 -TIAM2 8.07E-01 -CCR5 8.07E-01 -OR4A47 8.07E-01 -ZNF446 8.07E-01 -IL1A 8.07E-01 -TMEM8A 8.07E-01 -OR5K3 8.07E-01 -FAM173B 8.07E-01 -TAS2R60 8.07E-01 -OR8H2 8.07E-01 -MEA1 8.08E-01 -TIGD3 8.08E-01 -ARHGEF16 8.08E-01 -TCN2 8.08E-01 -TMED1 8.08E-01 -MLPH 8.08E-01 -DAND5 8.08E-01 -CMTM2 8.08E-01 -SLC22A15 8.08E-01 -DSCC1 8.08E-01 -RSPH3 8.08E-01 -C12orf29 8.08E-01 -CCR3 8.08E-01 -SGMS2 8.08E-01 -CRYBB3 8.08E-01 -OCIAD2 8.09E-01 -DYNC2LI1 8.09E-01 -IFNA8 8.09E-01 -UIMC1 8.09E-01 -CLECL1 8.09E-01 -SORBS1 8.09E-01 -SFT2D2 8.09E-01 -MYCBPAP 8.09E-01 -LGALS14 8.09E-01 -AIFM2 8.09E-01 -EHBP1L1 8.09E-01 -LRSAM1 8.09E-01 -OR2L2 8.09E-01 -ECHDC2 8.09E-01 -CPSF3L 8.10E-01 -TMEM99 8.10E-01 -RIPK3 8.10E-01 -UROC1 8.10E-01 -GLYCTK 8.10E-01 -ZNF674 8.10E-01 -KANK1 8.10E-01 -OR51D1 8.10E-01 -OR6C65 8.10E-01 -OR5L2 8.10E-01 -DPY19L3 8.10E-01 -GPRASP1 8.10E-01 -C6orf25 8.10E-01 -PSKH2 8.10E-01 -IFNE 8.10E-01 -RTN4IP1 8.11E-01 -HOOK1 8.11E-01 -ESD 8.11E-01 -MRPL22 8.11E-01 -NBN 8.11E-01 -CEACAM3 8.11E-01 -HUS1 8.11E-01 -KIAA1033 8.11E-01 -SLC9A8 8.11E-01 -ANO4 8.11E-01 -NCOA7 8.11E-01 -TDG 8.11E-01 -DHX29 8.11E-01 -CDHR5 8.11E-01 -SNX5 8.12E-01 -SPANXN2 8.12E-01 -RNASE6 8.12E-01 -ASGR1 8.12E-01 -KRTAP5-9 8.12E-01 -PDCD1LG2 8.12E-01 -DGAT1 8.12E-01 -PCDHB6 8.12E-01 -ZNF79 8.12E-01 -ATP1B4 8.12E-01 -FAAH 8.12E-01 -RHBDL2 8.12E-01 -SLC22A14 8.12E-01 -GLOD4 8.12E-01 -CDKN3 8.12E-01 -PLA2G4F 8.13E-01 -KLHDC7A 8.13E-01 -C5orf20 8.13E-01 -SLC1A7 8.13E-01 -MCM4 8.13E-01 -OR3A3 8.13E-01 -FAM151B 8.13E-01 -UBXN6 8.13E-01 -CHP2 8.13E-01 -C17orf47 8.13E-01 -LXN 8.13E-01 -MRPL46 8.13E-01 -RTP4 8.13E-01 -HPS1 8.13E-01 -NDUFV2 8.14E-01 -SNX4 8.14E-01 -SPP2 8.14E-01 -SLC22A8 8.14E-01 -PAAF1 8.14E-01 -ZNF836 8.14E-01 -SNX20 8.14E-01 -LTA4H 8.14E-01 -TACR2 8.14E-01 -ESF1 8.14E-01 -AARS2 8.14E-01 -C22orf43 8.14E-01 -QSOX1 8.14E-01 -UGGT1 8.14E-01 -NEDD1 8.14E-01 -METTL4 8.15E-01 -WFDC1 8.15E-01 -MTERFD2 8.15E-01 -MRPL44 8.15E-01 -LRWD1 8.15E-01 -DNAJC15 8.15E-01 -MTHFD1L 8.15E-01 -OR9Q2 8.15E-01 -ELN 8.15E-01 -NPM2 8.15E-01 -DNAJA4 8.15E-01 -DYNC1I1 8.15E-01 -WDR3 8.15E-01 -KLF11 8.15E-01 -ZNF454 8.16E-01 -ACSM5 8.16E-01 -NAPSA 8.16E-01 -EPN3 8.16E-01 -PSMG1 8.16E-01 -NECAB2 8.16E-01 -KRTAP5-2 8.16E-01 -NAT2 8.16E-01 -TIRAP 8.16E-01 -ATP6V0D2 8.16E-01 -PDE6C 8.16E-01 -PRG3 8.16E-01 -IMP4 8.16E-01 -SYT12 8.16E-01 -RRP8 8.16E-01 -MOXD1 8.17E-01 -VPS16 8.17E-01 -ADAM30 8.17E-01 -PTGR2 8.17E-01 -PIWIL2 8.17E-01 -NOS3 8.17E-01 -S100A4 8.17E-01 -CENPQ 8.17E-01 -NQO2 8.17E-01 -S100A13 8.17E-01 -ZNF23 8.17E-01 -MTFMT 8.17E-01 -REP15 8.17E-01 -TBPL2 8.17E-01 -DAK 8.17E-01 -DNAJB2 8.18E-01 -MR1 8.18E-01 -ZNF416 8.18E-01 -RHPN1 8.18E-01 -TMEM144 8.18E-01 -UFSP2 8.18E-01 -DPH1 8.18E-01 -CALCOCO2 8.18E-01 -FANCE 8.18E-01 -OR12D3 8.18E-01 -HAO1 8.18E-01 -ATP4B 8.18E-01 -ZNF138 8.18E-01 -ADAMTSL3 8.18E-01 -KANK4 8.19E-01 -TMC1 8.19E-01 -RIMS1 8.19E-01 -PCM1 8.19E-01 -AADAC 8.19E-01 -CLEC12A 8.19E-01 -BTBD1 8.19E-01 -NAGK 8.19E-01 -C19orf18 8.19E-01 -FBXO39 8.19E-01 -NME6 8.19E-01 -ELOVL2 8.19E-01 -GPR142 8.19E-01 -OR4L1 8.19E-01 -GTF3C3 8.19E-01 -TTLL9 8.20E-01 -FBXW9 8.20E-01 -WDR4 8.20E-01 -APOA1BP 8.20E-01 -LMAN2L 8.20E-01 -GABPB2 8.20E-01 -C16orf78 8.20E-01 -RSPH6A 8.20E-01 -TOP2B 8.20E-01 -LCN1 8.20E-01 -SYT8 8.20E-01 -NCR3 8.20E-01 -CST11 8.20E-01 -SLITRK6 8.20E-01 -TTC39A 8.21E-01 -PDCL3 8.21E-01 -GYPC 8.21E-01 -NUFIP1 8.21E-01 -SPATA19 8.21E-01 -ANKRD1 8.21E-01 -CDK5RAP3 8.21E-01 -FAM109B 8.21E-01 -ELF5 8.21E-01 -GLO1 8.21E-01 -SPHK1 8.21E-01 -CR1L 8.21E-01 -AGTR1 8.21E-01 -NT5DC1 8.21E-01 -P4HA3 8.21E-01 -HAPLN3 8.22E-01 -ACP6 8.22E-01 -SHMT2 8.22E-01 -GGT5 8.22E-01 -LRRC48 8.22E-01 -PNPLA6 8.22E-01 -ACE 8.22E-01 -VPS33B 8.22E-01 -SLC43A1 8.22E-01 -DHX34 8.22E-01 -C1orf127 8.22E-01 -ULK2 8.22E-01 -ACBD4 8.22E-01 -PIWIL1 8.22E-01 -CD3G 8.23E-01 -VWCE 8.23E-01 -GART 8.23E-01 -OTOP2 8.23E-01 -C8G 8.23E-01 -ZNF562 8.23E-01 -OR1S2 8.23E-01 -PIGK 8.23E-01 -DISC1 8.23E-01 -MGMT 8.23E-01 -ICAM4 8.23E-01 -ZNF765 8.23E-01 -SLC4A1AP 8.23E-01 -PON2 8.23E-01 -SKA3 8.23E-01 -GYLTL1B 8.24E-01 -ALDH8A1 8.24E-01 -TM4SF20 8.24E-01 -CYP2F1 8.24E-01 -GHRHR 8.24E-01 -OR52K1 8.24E-01 -OR7E24 8.24E-01 -ZNF136 8.24E-01 -GLP2R 8.24E-01 -SHISA5 8.24E-01 -OR8K5 8.24E-01 -PROM2 8.24E-01 -SLC35D2 8.24E-01 -RBKS 8.24E-01 -CHID1 8.25E-01 -OR9A2 8.25E-01 -ZNF616 8.25E-01 -NDUFA6 8.25E-01 -CPA1 8.25E-01 -CASP14 8.25E-01 -RAP1GDS1 8.25E-01 -PCSK5 8.25E-01 -TAS2R41 8.25E-01 -GGT6 8.25E-01 -CNPY4 8.25E-01 -SIGLEC8 8.25E-01 -ADAMTS18 8.25E-01 -OR2D3 8.25E-01 -OR5T1 8.25E-01 -CWH43 8.26E-01 -MYBPH 8.26E-01 -DDX43 8.26E-01 -PENK 8.26E-01 -TXNDC2 8.26E-01 -ANXA1 8.26E-01 -GMCL1 8.26E-01 -TNFAIP6 8.26E-01 -ADH5 8.26E-01 -PGPEP1L 8.26E-01 -ZNF776 8.26E-01 -HIST1H1T 8.26E-01 -GALM 8.26E-01 -C12orf42 8.26E-01 -CARD9 8.27E-01 -FAM83D 8.27E-01 -GSTM3 8.27E-01 -CLCA1 8.27E-01 -LRRFIP1 8.27E-01 -PPIL4 8.27E-01 -TAF6 8.27E-01 -UPK2 8.27E-01 -EXOSC7 8.27E-01 -ZNF230 8.27E-01 -LNX1 8.27E-01 -ZNF714 8.27E-01 -TAS2R9 8.27E-01 -COG4 8.27E-01 -FAM3C 8.27E-01 -CFHR1 8.28E-01 -OR8K3 8.28E-01 -SLC39A7 8.28E-01 -RGS13 8.28E-01 -APOBEC1 8.28E-01 -UGT2A3 8.28E-01 -DEFB126 8.28E-01 -SYNGR4 8.28E-01 -RFPL3 8.28E-01 -C9orf117 8.28E-01 -HAAO 8.28E-01 -ZNF665 8.28E-01 -WDR73 8.28E-01 -SNX15 8.28E-01 -TAS2R14 8.29E-01 -RABL2B 8.29E-01 -PIGQ 8.29E-01 -C6orf15 8.29E-01 -MYLK4 8.29E-01 -UBQLNL 8.29E-01 -PLA2G2A 8.29E-01 -MAMDC2 8.29E-01 -FOLR1 8.29E-01 -ABHD3 8.29E-01 -VAMP7 8.29E-01 -LGMN 8.29E-01 -GPR1 8.29E-01 -BUB1 8.29E-01 -ZDHHC6 8.29E-01 -CIB4 8.30E-01 -NSUN3 8.30E-01 -SSX7 8.30E-01 -PARP16 8.30E-01 -GSG2 8.30E-01 -TMEM126A 8.30E-01 -DOPEY2 8.30E-01 -ZFP30 8.30E-01 -VPS45 8.30E-01 -BOLL 8.30E-01 -LYVE1 8.30E-01 -ZNF80 8.30E-01 -SMC6 8.30E-01 -POLE2 8.30E-01 -PLA2G1B 8.31E-01 -IL18R1 8.31E-01 -ZNF41 8.31E-01 -VN1R4 8.31E-01 -AS3MT 8.31E-01 -MRPL45 8.31E-01 -CCDC104 8.31E-01 -EXOSC8 8.31E-01 -PLK4 8.31E-01 -NSL1 8.31E-01 -C7orf57 8.31E-01 -CASP1 8.31E-01 -PPEF2 8.31E-01 -VWA3A 8.31E-01 -TTC23L 8.31E-01 -TTC7A 8.32E-01 -SAAL1 8.32E-01 -GPR39 8.32E-01 -C4orf6 8.32E-01 -OR56B4 8.32E-01 -COG2 8.32E-01 -MTUS1 8.32E-01 -CARD14 8.32E-01 -POT1 8.32E-01 -IMPA1 8.32E-01 -ALDH16A1 8.32E-01 -PPWD1 8.32E-01 -EVC 8.32E-01 -PCDHB14 8.32E-01 -ZNF582 8.33E-01 -OR1L3 8.33E-01 -SUN5 8.33E-01 -IL8 8.33E-01 -TRIM58 8.33E-01 -PRSS16 8.33E-01 -GNLY 8.33E-01 -DCP1B 8.33E-01 -OR6C75 8.33E-01 -CCNA1 8.33E-01 -C1orf116 8.33E-01 -PASK 8.33E-01 -SPESP1 8.33E-01 -WNT16 8.33E-01 -OR14I1 8.33E-01 -GGA2 8.34E-01 -P2RX4 8.34E-01 -PLK3 8.34E-01 -ZNF461 8.34E-01 -KCNAB3 8.34E-01 -HEATR5B 8.34E-01 -TACR1 8.34E-01 -PCNXL2 8.34E-01 -PCDHA11 8.34E-01 -DCAF11 8.34E-01 -HLA-G 8.34E-01 -TGOLN2 8.34E-01 -TMEM106A 8.34E-01 -OR1M1 8.34E-01 -BLZF1 8.35E-01 -PPM1D 8.35E-01 -SPZ1 8.35E-01 -ASGR2 8.35E-01 -FAM169B 8.35E-01 -CEACAM4 8.35E-01 -TRMU 8.35E-01 -OR4K5 8.35E-01 -FCRL4 8.35E-01 -ATG2B 8.35E-01 -ZNF878 8.35E-01 -USP54 8.35E-01 -TXNDC16 8.35E-01 -ARRDC2 8.35E-01 -RBM43 8.35E-01 -CLDND1 8.36E-01 -ECM2 8.36E-01 -GFM1 8.36E-01 -FBXO36 8.36E-01 -PEX11G 8.36E-01 -SLC22A11 8.36E-01 -BTN3A2 8.36E-01 -RINT1 8.36E-01 -UHRF1BP1 8.36E-01 -SLC17A9 8.36E-01 -SRRD 8.36E-01 -PAQR6 8.36E-01 -ANKRD55 8.36E-01 -TRUB2 8.36E-01 -YIF1A 8.37E-01 -FAM114A1 8.37E-01 -ACSL5 8.37E-01 -ZNF721 8.37E-01 -POLH 8.37E-01 -STAMBP 8.37E-01 -ANGPTL4 8.37E-01 -ULBP3 8.37E-01 -LCE3D 8.37E-01 -SELE 8.37E-01 -LAMC3 8.37E-01 -CD4 8.37E-01 -STX19 8.37E-01 -SLC9A3R1 8.37E-01 -IGSF8 8.37E-01 -C2orf53 8.38E-01 -ZNF530 8.38E-01 -OR4F15 8.38E-01 -ZNF432 8.38E-01 -APPL1 8.38E-01 -C2orf73 8.38E-01 -TMBIM1 8.38E-01 -TREM2 8.38E-01 -XKR3 8.38E-01 -OR4C16 8.38E-01 -C4orf40 8.38E-01 -ZNF7 8.38E-01 -MCC 8.38E-01 -CD276 8.38E-01 -GALNT6 8.39E-01 -KCNIP2 8.39E-01 -ULK3 8.39E-01 -AEN 8.39E-01 -LGALS3 8.39E-01 -C1orf158 8.39E-01 -GIMAP2 8.39E-01 -GSDMD 8.39E-01 -ZNF488 8.39E-01 -DHX57 8.39E-01 -FUT6 8.39E-01 -KRTAP4-3 8.39E-01 -ROPN1B 8.39E-01 -ALDH1L2 8.39E-01 -PTPN13 8.39E-01 -TMEM59 8.40E-01 -NUPL2 8.40E-01 -FAM65C 8.40E-01 -PLSCR1 8.40E-01 -SCNN1D 8.40E-01 -MICB 8.40E-01 -OR2C3 8.40E-01 -FCGR2B 8.40E-01 -LAMB2 8.40E-01 -OR5R1 8.40E-01 -DCAF17 8.40E-01 -PCDHB7 8.40E-01 -RNF133 8.40E-01 -UNC45B 8.40E-01 -TP53INP1 8.41E-01 -SCYL3 8.41E-01 -KRTAP9-2 8.41E-01 -ODAM 8.41E-01 -TP53TG5 8.41E-01 -MRPL37 8.41E-01 -SEMA4B 8.41E-01 -ANO2 8.41E-01 -PGLYRP2 8.41E-01 -ZNF514 8.41E-01 -ABHD11 8.41E-01 -GOLGB1 8.41E-01 -OR4K1 8.41E-01 -HPGDS 8.41E-01 -TRIM54 8.41E-01 -LAIR1 8.42E-01 -CCNB2 8.42E-01 -RALYL 8.42E-01 -HEBP2 8.42E-01 -LRCH3 8.42E-01 -HSPA4L 8.42E-01 -CCDC34 8.42E-01 -LYPLAL1 8.42E-01 -C6orf1 8.42E-01 -FAM187B 8.42E-01 -PRAP1 8.42E-01 -ERCC3 8.42E-01 -FAM73A 8.42E-01 -OR2F1 8.42E-01 -MIPOL1 8.43E-01 -OR5A1 8.43E-01 -TTC4 8.43E-01 -CCDC54 8.43E-01 -EPHX1 8.43E-01 -ASMTL 8.43E-01 -PLA2G6 8.43E-01 -TACC2 8.43E-01 -VPS53 8.43E-01 -TAS2R39 8.43E-01 -KIF25 8.43E-01 -MAST2 8.43E-01 -TMEM202 8.43E-01 -TLE6 8.43E-01 -CWC27 8.43E-01 -VMO1 8.44E-01 -CCDC40 8.44E-01 -TMEM207 8.44E-01 -HHLA2 8.44E-01 -PRDX3 8.44E-01 -HSPA1L 8.44E-01 -GEM 8.44E-01 -OR1J2 8.44E-01 -ETAA1 8.44E-01 -C22orf31 8.44E-01 -GPC5 8.44E-01 -ZNF284 8.44E-01 -SAA2 8.44E-01 -RAD1 8.44E-01 -ZNF433 8.45E-01 -PLEKHA1 8.45E-01 -ZNF45 8.45E-01 -VEZT 8.45E-01 -KIAA1109 8.45E-01 -RRP7A 8.45E-01 -RFXANK 8.45E-01 -GOSR2 8.45E-01 -VCX 8.45E-01 -TAS2R46 8.45E-01 -TMEM156 8.45E-01 -KRIT1 8.45E-01 -MARCH8 8.45E-01 -FABP6 8.45E-01 -NCKIPSD 8.45E-01 -AHSG 8.46E-01 -YARS2 8.46E-01 -BAAT 8.46E-01 -LANCL1 8.46E-01 -GSTA2 8.46E-01 -CEBPZ 8.46E-01 -FCHSD2 8.46E-01 -KRTAP5-10 8.46E-01 -LARS 8.46E-01 -FIBP 8.46E-01 -PRG2 8.46E-01 -GBGT1 8.46E-01 -TLR4 8.46E-01 -ARHGEF19 8.46E-01 -SLC6A18 8.47E-01 -DUS4L 8.47E-01 -TUT1 8.47E-01 -RTN3 8.47E-01 -PIR 8.47E-01 -GIMAP8 8.47E-01 -PPIG 8.47E-01 -PDPN 8.47E-01 -THEMIS 8.47E-01 -ATF3 8.47E-01 -CHKB 8.47E-01 -C6orf58 8.47E-01 -CCDC84 8.47E-01 -ZSCAN1 8.47E-01 -IL1F10 8.47E-01 -GLIPR1L1 8.48E-01 -VRK1 8.48E-01 -PCMTD1 8.48E-01 -ZCCHC5 8.48E-01 -DKK3 8.48E-01 -LYPD4 8.48E-01 -GPR126 8.48E-01 -CCNH 8.48E-01 -MRPL1 8.48E-01 -ENTPD6 8.48E-01 -C1orf94 8.48E-01 -NT5DC3 8.48E-01 -CLEC1A 8.48E-01 -CHGB 8.48E-01 -COQ6 8.49E-01 -GSTA5 8.49E-01 -KLRD1 8.49E-01 -MAP3K6 8.49E-01 -EXOC6 8.49E-01 -HIF3A 8.49E-01 -KIAA1328 8.49E-01 -HDAC10 8.49E-01 -CEACAM7 8.49E-01 -GPR56 8.49E-01 -DDX54 8.49E-01 -OR5H1 8.49E-01 -ANKRD42 8.49E-01 -CLK1 8.49E-01 -TAS2R20 8.49E-01 -IL17RE 8.50E-01 -OR2Z1 8.50E-01 -LRRC2 8.50E-01 -GPA33 8.50E-01 -BHMT 8.50E-01 -NLRC4 8.50E-01 -LRRC16A 8.50E-01 -SHCBP1 8.50E-01 -LRRC16B 8.50E-01 -CEP192 8.50E-01 -GTPBP10 8.50E-01 -ERICH1 8.50E-01 -ADAMTS20 8.50E-01 -MS4A3 8.50E-01 -B3GALNT2 8.50E-01 -UTS2 8.51E-01 -DGAT2 8.51E-01 -NAAA 8.51E-01 -THEM4 8.51E-01 -WNT2B 8.51E-01 -APOL3 8.51E-01 -ANO9 8.51E-01 -B3GNTL1 8.51E-01 -FAM161A 8.51E-01 -SIRPB2 8.51E-01 -GRK7 8.51E-01 -IQCD 8.51E-01 -OR51B6 8.51E-01 -SLC27A5 8.51E-01 -OR2T1 8.52E-01 -OR4X2 8.52E-01 -FILIP1 8.52E-01 -SH3YL1 8.52E-01 -ZNF862 8.52E-01 -FAM35A 8.52E-01 -HAUS2 8.52E-01 -GLYAT 8.52E-01 -NUP43 8.52E-01 -MKI67 8.52E-01 -OR2L3 8.52E-01 -ANKRD24 8.52E-01 -FSTL5 8.52E-01 -SYNE2 8.52E-01 -PIGG 8.52E-01 -LRRC46 8.53E-01 -PLD4 8.53E-01 -PGLYRP3 8.53E-01 -NAPRT1 8.53E-01 -ZNF790 8.53E-01 -ROBO4 8.53E-01 -EFCAB4B 8.53E-01 -ZIK1 8.53E-01 -BST1 8.53E-01 -RPUSD4 8.53E-01 -CD1B 8.53E-01 -LIG3 8.53E-01 -AIM2 8.53E-01 -MURC 8.53E-01 -CD300A 8.54E-01 -ALOX12 8.54E-01 -TPO 8.54E-01 -KPNA5 8.54E-01 -CEP72 8.54E-01 -MEP1B 8.54E-01 -RAD9B 8.54E-01 -KBTBD3 8.54E-01 -KIF17 8.54E-01 -FGFBP2 8.54E-01 -FN3KRP 8.54E-01 -ZNF479 8.54E-01 -SLC10A6 8.54E-01 -C1orf198 8.54E-01 -BAX 8.54E-01 -VN1R2 8.55E-01 -MRPS11 8.55E-01 -PLCB2 8.55E-01 -SEC22C 8.55E-01 -MOAP1 8.55E-01 -NCF4 8.55E-01 -ACOT4 8.55E-01 -SLC17A8 8.55E-01 -ORM1 8.55E-01 -GGT1 8.55E-01 -GBP7 8.55E-01 -GPR137B 8.55E-01 -FRMPD1 8.55E-01 -ZNF808 8.55E-01 -GALNT7 8.56E-01 -TRIM15 8.56E-01 -PSMB8 8.56E-01 -SEC16B 8.56E-01 -PLIN1 8.56E-01 -TAS2R5 8.56E-01 -TMEM43 8.56E-01 -TOP3A 8.56E-01 -LYSMD4 8.56E-01 -FAM124A 8.56E-01 -OR52N2 8.56E-01 -TTC26 8.56E-01 -OR5H14 8.56E-01 -KIF21A 8.56E-01 -PSORS1C1 8.56E-01 -C22orf23 8.57E-01 -MAGEE2 8.57E-01 -ZNF781 8.57E-01 -OR10AG1 8.57E-01 -POLR3C 8.57E-01 -IFNA4 8.57E-01 -NOD1 8.57E-01 -TCTE3 8.57E-01 -DPEP1 8.57E-01 -CA14 8.57E-01 -CYP2C18 8.57E-01 -C1orf63 8.57E-01 -MST1R 8.57E-01 -PDC 8.57E-01 -TG 8.58E-01 -ZNF570 8.58E-01 -RASSF1 8.58E-01 -C10orf10 8.58E-01 -TPD52L3 8.58E-01 -MMP13 8.58E-01 -CLEC4D 8.58E-01 -GLRX 8.58E-01 -PHACTR2 8.58E-01 -CST4 8.58E-01 -ZNF490 8.58E-01 -DSC1 8.58E-01 -RBP1 8.58E-01 -ATF6B 8.58E-01 -OR8I2 8.58E-01 -MMP25 8.59E-01 -ZNF283 8.59E-01 -ST8SIA6 8.59E-01 -BARD1 8.59E-01 -PCDHA12 8.59E-01 -C4orf17 8.59E-01 -EVPL 8.59E-01 -ARHGAP28 8.59E-01 -CTSE 8.59E-01 -CPNE7 8.59E-01 -AFP 8.59E-01 -OR10AD1 8.59E-01 -RAD52 8.59E-01 -APOH 8.59E-01 -SIGLEC7 8.60E-01 -PCDHB11 8.60E-01 -NMD3 8.60E-01 -LRRC19 8.60E-01 -ZNF451 8.60E-01 -AIF1 8.60E-01 -FUCA2 8.60E-01 -SLC39A11 8.60E-01 -ZCWPW2 8.60E-01 -KLF17 8.60E-01 -APOBEC3G 8.60E-01 -TTC31 8.60E-01 -MOCS2 8.60E-01 -SEMA4F 8.60E-01 -C2orf71 8.60E-01 -GALNT5 8.61E-01 -ZNF267 8.61E-01 -MADD 8.61E-01 -EPX 8.61E-01 -TRDN 8.61E-01 -ZNF235 8.61E-01 -OR3A1 8.61E-01 -PCDHA7 8.61E-01 -ERCC1 8.61E-01 -ZNF101 8.61E-01 -BUD13 8.61E-01 -FNDC1 8.61E-01 -OBSL1 8.61E-01 -GLIPR1L2 8.61E-01 -ZFP37 8.62E-01 -POLR1E 8.62E-01 -XRCC2 8.62E-01 -NEIL1 8.62E-01 -MPO 8.62E-01 -KCTD19 8.62E-01 -IFNK 8.62E-01 -PHACTR4 8.62E-01 -FAM83A 8.62E-01 -RASAL1 8.62E-01 -ZNF630 8.62E-01 -FBXO6 8.62E-01 -OR8J1 8.62E-01 -CDC42BPG 8.62E-01 -RFC3 8.62E-01 -C14orf93 8.63E-01 -ZNF160 8.63E-01 -OR13F1 8.63E-01 -GPR115 8.63E-01 -OR2T34 8.63E-01 -CTNNA3 8.63E-01 -NOD2 8.63E-01 -CDK10 8.63E-01 -DUSP27 8.63E-01 -C12orf65 8.63E-01 -AFM 8.63E-01 -GSTM5 8.63E-01 -NOM1 8.63E-01 -FAM189B 8.63E-01 -POLE 8.64E-01 -C5orf45 8.64E-01 -TLE3 8.64E-01 -ZNF709 8.64E-01 -SCTR 8.64E-01 -MAVS 8.64E-01 -IMPG2 8.64E-01 -FAM81B 8.64E-01 -MFF 8.64E-01 -PIF1 8.64E-01 -GALNT14 8.64E-01 -COQ3 8.64E-01 -MED17 8.64E-01 -ENTPD8 8.64E-01 -ODF3L1 8.64E-01 -GPR180 8.65E-01 -PCDHB3 8.65E-01 -APOL5 8.65E-01 -CD1C 8.65E-01 -CCDC107 8.65E-01 -OR6C6 8.65E-01 -BUB1B 8.65E-01 -SLC39A12 8.65E-01 -CYP20A1 8.65E-01 -ZNF197 8.65E-01 -CHMP4A 8.65E-01 -LMF1 8.65E-01 -CRHR2 8.65E-01 -PFAS 8.65E-01 -ZNF438 8.66E-01 -KCNK16 8.66E-01 -CDH24 8.66E-01 -CPA2 8.66E-01 -ZUFSP 8.66E-01 -IL33 8.66E-01 -C2orf16 8.66E-01 -CPNE1 8.66E-01 -CCDC70 8.66E-01 -MNAT1 8.66E-01 -TTC39C 8.66E-01 -EIF2AK4 8.66E-01 -KLHL5 8.66E-01 -NME1 8.66E-01 -CPB2 8.66E-01 -OR10V1 8.67E-01 -VIPR2 8.67E-01 -SLC35B3 8.67E-01 -APOBEC4 8.67E-01 -ZNF789 8.67E-01 -ELP2 8.67E-01 -ASPDH 8.67E-01 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8.75E-01 -SLC24A1 8.75E-01 -GBP2 8.75E-01 -ZNF397 8.76E-01 -LAMA1 8.76E-01 -STK32A 8.76E-01 -SLC25A24 8.76E-01 -PCDHB1 8.76E-01 -FBXL6 8.76E-01 -P2RY6 8.76E-01 -C1orf174 8.76E-01 -ANO3 8.76E-01 -RERG 8.76E-01 -QPCT 8.76E-01 -ZNF766 8.76E-01 -SLC28A1 8.76E-01 -ARID3C 8.76E-01 -BBS12 8.76E-01 -PEX11B 8.77E-01 -OSBPL1A 8.77E-01 -PCDHB13 8.77E-01 -SLC27A2 8.77E-01 -ANXA10 8.77E-01 -MS4A10 8.77E-01 -A1CF 8.77E-01 -MTX3 8.77E-01 -IFNA21 8.77E-01 -TEKT4 8.77E-01 -IBSP 8.77E-01 -SLC14A2 8.77E-01 -CC2D1B 8.77E-01 -ZNF599 8.77E-01 -AADACL2 8.78E-01 -DHDH 8.78E-01 -USP6NL 8.78E-01 -THSD1 8.78E-01 -PMPCB 8.78E-01 -TMC3 8.78E-01 -SECISBP2 8.78E-01 -OR9K2 8.78E-01 -CCDC36 8.78E-01 -ERCC4 8.78E-01 -STK33 8.78E-01 -INTS9 8.78E-01 -SNAPC3 8.78E-01 -CCDC109B 8.78E-01 -MICAL1 8.78E-01 -PCDHB12 8.79E-01 -OR13C9 8.79E-01 -DEK 8.79E-01 -HMOX2 8.79E-01 -NUDT13 8.79E-01 -OR5K1 8.79E-01 -CSAD 8.79E-01 -SDCCAG8 8.79E-01 -GPR97 8.79E-01 -IFT140 8.79E-01 -CENPO 8.79E-01 -RGS4 8.79E-01 -TP53I3 8.79E-01 -RARS2 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8.92E-01 -KIF20A 8.92E-01 -C11orf16 8.92E-01 -PDGFRL 8.92E-01 -OR2S2 8.92E-01 -AGK 8.92E-01 -TUBGCP6 8.92E-01 -ZFYVE26 8.92E-01 -GPR112 8.92E-01 -FBXO7 8.93E-01 -SURF2 8.93E-01 -FAIM 8.93E-01 -HIST1H1A 8.93E-01 -C6orf211 8.93E-01 -TRAF3IP2 8.93E-01 -PKD2L2 8.93E-01 -PCDHA9 8.93E-01 -ZIM3 8.93E-01 -FANK1 8.93E-01 -FAM71F1 8.93E-01 -ELMO3 8.93E-01 -DNMBP 8.93E-01 -CDHR1 8.93E-01 -P2RX5 8.93E-01 -MARK3 8.94E-01 -CCDC90B 8.94E-01 -ADAMTSL5 8.94E-01 -ZNF221 8.94E-01 -MPHOSPH9 8.94E-01 -LMLN 8.94E-01 -AKR1B15 8.94E-01 -CD34 8.94E-01 -FAM3B 8.94E-01 -CDCA7L 8.94E-01 -KIAA1919 8.94E-01 -TEPP 8.94E-01 -CCDC69 8.94E-01 -ENGASE 8.94E-01 -ADH1A 8.95E-01 -HLA-DQA2 8.95E-01 -C4orf19 8.95E-01 -ADCK1 8.95E-01 -CCKBR 8.95E-01 -OR52A5 8.95E-01 -NPSR1 8.95E-01 -NUDT12 8.95E-01 -SEMA4A 8.95E-01 -FRMPD2 8.95E-01 -RTBDN 8.95E-01 -CDH17 8.95E-01 -KIRREL2 8.95E-01 -ATXN3 8.95E-01 -EXD3 8.95E-01 -DDX31 8.96E-01 -ZNF180 8.96E-01 -PPP1R12B 8.96E-01 -SNAPC4 8.96E-01 -CYP4X1 8.96E-01 -ADCK2 8.96E-01 -OR5T3 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-PCDHGA2 9.04E-01 -BDP1 9.04E-01 -THOC6 9.04E-01 -C1orf141 9.04E-01 -PRG4 9.05E-01 -SORBS3 9.05E-01 -PSMF1 9.05E-01 -OR5H6 9.05E-01 -TRAK2 9.05E-01 -CTAGE5 9.05E-01 -CHCHD6 9.05E-01 -TMED6 9.05E-01 -LILRA4 9.05E-01 -SEPT4 9.05E-01 -GPATCH2 9.05E-01 -CTBS 9.05E-01 -OR5D14 9.05E-01 -CDK20 9.05E-01 -ACO1 9.05E-01 -HAUS3 9.06E-01 -CDON 9.06E-01 -LRRC61 9.06E-01 -OR2M7 9.06E-01 -FCRLA 9.06E-01 -C14orf166B 9.06E-01 -CYP3A7 9.06E-01 -CEACAM18 9.06E-01 -TCHHL1 9.06E-01 -C1orf112 9.06E-01 -MRPL47 9.06E-01 -DERL3 9.06E-01 -NSUN4 9.06E-01 -SLC6A20 9.06E-01 -AURKC 9.07E-01 -NUF2 9.07E-01 -PTGS1 9.07E-01 -PLBD2 9.07E-01 -TRMT2A 9.07E-01 -GTPBP8 9.07E-01 -MMP1 9.07E-01 -CDCA2 9.07E-01 -SHQ1 9.07E-01 -GSDMA 9.07E-01 -LFNG 9.07E-01 -TRMT11 9.07E-01 -DCST2 9.07E-01 -SLC10A5 9.07E-01 -TRAF3IP1 9.07E-01 -CSNK1A1L 9.08E-01 -PSMC3IP 9.08E-01 -ACSS3 9.08E-01 -PRDM7 9.08E-01 -TPD52 9.08E-01 -B4GALNT3 9.08E-01 -PADI3 9.08E-01 -C3orf67 9.08E-01 -SPO11 9.08E-01 -AHNAK2 9.08E-01 -RCN3 9.08E-01 -SLC17A4 9.08E-01 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--- a/dir_plugins/LocalID.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,344 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - LocalID - -=head1 SYNOPSIS - - mv LocalID.pm ~/.vep/Plugins - - ## first run create database - - # EITHER create from Ensembl variation database - # VERY slow but includes variant synonyms, if not required see next command - ./vep -i variant_ids.txt --plugin LocalID,create_db=1 -safe - - # OR create from cache directory - # faster but does not include synonyms - # parameter passed to from_cache may be full path to cache e.g. $HOME/.vep/homo_sapiens/88_GRCh38 - # cache may be tabix converted or in default state (http://www.ensembl.org/info/docs/tools/vep/script/vep_cache.html#convert) - ./vep -i variant_ids.txt --plugin LocalID,create_db=1,from_cache=1 -safe - - # subsequent runs - ./vep -i variant_ids.txt --plugin LocalID - - # db file can be specified with db=[file] - # default file name is $HOME/.vep/[species]_[version]_[assembly].variant_ids.sqlite3 - ./vep -i variant_ids.txt --plugin LocalID,db=my_db_file.txt - -=head1 DESCRIPTION - - The LocalID plugin allows you to use variant IDs as input without making a database connection. - - Requires sqlite3. - - A local sqlite3 database is used to look up variant IDs; this is generated either from Ensembl's - public database (very slow, but includes synonyms), or from a VEP cache file (faster, excludes - synonyms). - - NB this plugin is NOT compatible with the ensembl-tools variant_effect_predictor.pl version of VEP. - -=cut - -package LocalID; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; -use Bio::EnsEMBL::VEP::Parser::ID; -use Bio::EnsEMBL::VEP::Constants; -use Bio::EnsEMBL::VEP::Utils qw(get_compressed_filehandle); - - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $param_hash = $self->params_to_hash(); - my $config = $self->{config}; - my $species = $config->{species} || 'homo_sapiens'; - my $db; - - unless($db = $param_hash->{db}) { - my $version = - $config->{db_version} || - $config->{cache_version} || - $Bio::EnsEMBL::VEP::Constants::VEP_VERSION || - 'Bio::EnsEMBL::Registry'->software_version || - undef; - my $assembly = $config->{assembly}; - my $dir = $param_hash->{dir} || $config->{dir}; - - die("ERROR: Unable to determine software version - if using --offline, add --cache_version [version] or add the ID database name to your --plugin string as \"db=[file]\"\n") unless $version; - die("ERROR: Unable to determine assembly version - if using --offline, add --assembly [version] or add the ID database name to your --plugin string as \"db=[file]\"\n") unless $assembly; - $db = sprintf("%s/%s_%i_%s.variant_ids.sqlite3", $dir, $species, $version, $assembly); - } - - # create DB? - $self->create_db($db, $species, $param_hash) if $param_hash->{create_db}; - - die("ERROR: DB file $db not found - you need to download or create it first, see documentation in plugin file\n") unless -e $db; - - $self->config->{_localid_db_file} = $db; - - return $self; -} - -sub create_db { - my ($self, $db, $species, $param_hash) = @_; - - # requites sqlite3 command line tool - die("ERROR: sqlite3 command not found in path\n") unless `which sqlite3` =~ /\/sqlite3/; - - my $config = $self->{config}; - - die("ERROR: DB file $db already exists - remove and re-run to overwrite\n") if -e $db; - - print STDERR "## LocalID plugin\n # Creating database of variant IDs - this may take some time\n" unless $config->{quiet}; - - my $tmpfile = "$db.tmp$$"; - open my $tmp_handle, ">$tmpfile" or die "ERROR: Unable to write to $tmpfile\n"; - - if(my $cache_dir = $param_hash->{from_cache}) { - - # attempt to interpret cache dir from command line opts - if($cache_dir eq '1') { - my $version = - $config->{cache_version} || - $config->{db_version} || - $Bio::EnsEMBL::VEP::Constants::VEP_VERSION || - ($config->{reg} ? $config->{reg}->software_version : undef); - my $assembly = $config->{assembly}; - my $dir = $config->{dir_cache} || $config->{dir}; - - $cache_dir = "$dir\/$species\/$version\_$assembly"; - } - - print STDERR " # attempting to create from $cache_dir\n" unless $config->{quiet}; - $self->_tmp_file_from_cache($cache_dir, $tmp_handle); - } - else { - print STDERR " # attempting to create from variation database for $species\n" unless $config->{quiet}; - $self->_tmp_file_from_var_db($species, $tmp_handle); - } - - close $tmp_handle; - - # create database - my $dbh = DBI->connect("dbi:SQLite:dbname=$db","",""); - $dbh->do("CREATE TABLE ids(id, chr, start, end, alleles, strand)"); - - # load tmp file into table - print STDERR " # loading database\n" unless $config->{quiet}; - my $cmd = qq{sqlite3 $db '.import $tmpfile ids'}; - `$cmd 2>&1` and die("ERROR: Failed to import $tmpfile to $db\n"); - unlink($tmpfile); - - # index - print STDERR " # indexing database\n" unless $config->{quiet}; - $dbh->do("CREATE INDEX id_idx ON ids(id)"); - - print STDERR " # successfully built database $db\n" unless $config->{quiet}; -} - -sub _tmp_file_from_cache { - my ($self, $cache_dir, $tmp_handle) = @_; - my $config = $self->{config}; - - die("ERROR: Cache dir $cache_dir not found or not a directory\n") unless -d $cache_dir; - - # read info - open INFO, $cache_dir.'/info.txt' or die("ERROR: No info.txt file found in $cache_dir\n"); - - my %cols; - while(<INFO>) { - next unless /^variation_cols/; - chomp; - my @tmp_cols = split(',', (split("\t", $_))[1]); - $cols{$tmp_cols[$_]} = $_ for 0..$#tmp_cols; - last; - } - close INFO; - - # get all chromosome dirs - opendir DIR, $cache_dir or die("ERROR: Could not read dir $cache_dir\n"); - my @chrs = grep {-d $cache_dir.'/'.$_ && !/^\./} readdir DIR; - closedir DIR; - - foreach my $chr(@chrs) { - opendir CHR, $cache_dir.'/'.$chr; - my @all_files = grep {/var/ && !/\.(tb|cs)i$/} readdir CHR; - closedir CHR; - - my @files = grep {/all_vars/} @all_files; - @files = @all_files unless @files; - - foreach my $file(@files) { - my $fh = get_compressed_filehandle($cache_dir.'/'.$chr.'/'.$file, 1); - - my $delim; - - while(<$fh>) { - unless($delim) { - $delim = /\t/ ? "\t" : " "; - } - - chomp; - my @split = map {($_ || '') eq '.' ? undef : $_} split($delim); - - # id, chr, start, end, alleles, strand - print $tmp_handle join("|", - $split[$cols{variation_name}], - $chr, - $split[$cols{start}], - $split[$cols{end}] || $split[$cols{start}], - $split[$cols{allele_string}] || '', - $split[$cols{strand}] || 1, - )."\n"; - } - - close $fh; - } - } -} - -sub _tmp_file_from_var_db { - my ($self, $species, $tmp_handle) = @_; - my $config = $self->{config}; - - my $var_dbc = Bio::EnsEMBL::Registry->get_adaptor($species, 'variation', 'variation')->db->dbc; - - my $mysql = $var_dbc->prepare(qq{ - SELECT v.name, s.name, vf.seq_region_start, vf.seq_region_end, vf.allele_string, vf.seq_region_strand - FROM variation v, variation_feature vf, seq_region s - WHERE v.variation_id = vf.variation_id - AND vf.seq_region_id = s.seq_region_id - }, {mysql_use_result => 1}); - - my ($i, $c, $s, $e, $a, $d); - $mysql->execute(); - $mysql->bind_columns(\$i, \$c, \$s, \$e, \$a, \$d); - print $tmp_handle join("|", ($i, $c, $s, $e, $a, $d))."\n" while $mysql->fetch(); - $mysql->finish(); - - # do synonyms - print STDERR "Processing synonyms\n" unless $config->{quiet}; - $mysql = $var_dbc->prepare(qq{ - SELECT v.name, s.name, vf.seq_region_start, vf.seq_region_end, vf.allele_string, vf.seq_region_strand - FROM variation_synonym v, variation_feature vf, seq_region s - WHERE v.variation_id = vf.variation_id - AND vf.seq_region_id = s.seq_region_id - }, {mysql_use_result => 1}); - - $mysql->execute(); - $mysql->bind_columns(\$i, \$c, \$s, \$e, \$a, \$d); - print $tmp_handle join("|", ($i, $c, $s, $e, $a, $d))."\n" while $mysql->fetch(); - $mysql->finish(); -} - -sub run { - return {}; -} - -1; - - - - -########################################### -### Redefine methods in existing module ### -########################################### - -package Bio::EnsEMBL::VEP::Parser::ID; - -no warnings qw(redefine); -sub new { - my $caller = shift; - my $class = ref($caller) || $caller; - - my $self = $class->SUPER::new(@_); - - return $self; -} - -sub create_VariationFeatures { - my $self = shift; - - my $parser = $self->parser; - $parser->next(); - - $self->skip_empty_lines(); - - return [] unless $parser->{record}; - - $self->line_number($self->line_number + 1); - - my $id = $parser->get_value; - - # remove whitespace - $id =~ s/\s+//g; - - my $db = $self->id_db; - my $sth = $self->{_id_sth} ||= $db->prepare("SELECT chr, start, end, alleles, strand FROM ids WHERE id = ?"); - my $ad = $self->{_var_ad} ||= $self->get_adaptor('variation', 'VariationFeature'); - - my @vfs; - my ($c, $s, $e, $a, $d); - $sth->execute($id); - $sth->bind_columns(\$c, \$s, \$e, \$a, \$d); - - push @vfs, Bio::EnsEMBL::Variation::VariationFeature->new_fast({ - start => $s, - end => $e, - allele_string => $a, - strand => $d, - map_weight => 1, - adaptor => $ad, - variation_name => $id, - chr => $c, - }) while $sth->fetch; - - $sth->finish(); - - return $self->post_process_vfs(\@vfs); -} - -sub id_db { - my $self = shift; - - unless(exists($self->{_id_db})) { - throw("ERROR: ID database not defined or detected - possible plugin compile failure\n") unless my $db = $self->config->{_params}->{_localid_db_file}; - throw("ERROR: ID database file $db not found - you need to download or create it first, see documentation in plugin file\n") unless -e $db; - $self->{_id_db} = DBI->connect("dbi:SQLite:dbname=$db","",""); - } - - return $self->{_id_db}; -} - -1;
--- a/dir_plugins/MPC.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,135 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - MPC - -=head1 SYNOPSIS - - mv MPC.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin MPC,fordist_constraint_official_mpc_values.txt.gz - -=head1 DESCRIPTION - - A VEP plugin that retrieves MPC scores for variants from a tabix-indexed MPC data file. - - MPC is a missense deleteriousness metric based on the analysis of genic regions - depleted of missense mutations in the Exome Agggregation Consortium (ExAC) data. - - The MPC score is the product of work by Kaitlin Samocha (ks20@sanger.ac.uk). - Publication currently in pre-print: Samocha et al bioRxiv 2017 (TBD) - - The MPC score file is available to download from: - - ftp://ftp.broadinstitute.org/pub/ExAC_release/release1/regional_missense_constraint/ - - The data are currently mapped to GRCh37 only. Not all transcripts are included; see - README in the above directory for exclusion criteria. - -=cut - -package MPC; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -my %INCLUDE_SO = map {$_ => 1} qw(missense_variant stop_lost stop_gained start_lost); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - - $self->get_user_params(); - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { MPC => 'MPC score' }; -} - -sub run { - my ($self, $tva) = @_; - - # only for missense variants - return {} unless grep {$INCLUDE_SO{$_->SO_term}} @{$tva->get_all_OverlapConsequences}; - - my $vf = $tva->variation_feature; - - return {} unless $vf->{start} eq $vf->{end}; - - # get allele, reverse comp if needed - my $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - return {} unless $allele =~ /^[ACGT]$/; - - # get transcript stable ID - my $tr_id = $tva->transcript->stable_id; - - my ($res) = grep { - $_->{pos} == $vf->{start} && - $_->{alt} eq $allele && - $_->{tr} eq $tr_id - } @{$self->get_data($vf->{chr}, $vf->{start}, $vf->{end})}; - - return $res ? { MPC => $res->{MPC} } : {}; -} - -sub parse_data { - my ($self, $line) = @_; - - my @split = split /\t/, $line; - - return { - pos => $split[1], - alt => $split[3], - tr => $split[5], - MPC => $split[-1], - }; -} - -sub get_start { - return $_[1]->{pos}; -} - -sub get_end { - return $_[1]->{pos}; -} - -1;
--- a/dir_plugins/MTR.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,153 +0,0 @@ -=head1 CONTACT - - Slave Petrovski <slavep@unimelb.edu.au> - Michael Silk <silkm@student.unimelb.edu.au> - -=cut - -=head1 NAME - - MTR (Missense Tolerance Ratio) - -=head1 SYNOPSIS - - mv MTR.pm ~/.vep/Plugins - curl -O ftp://mtr-viewer.mdhs.unimelb.edu.au/pub/mtrflatfile_1.0.txt.gz - curl -O ftp://mtr-viewer.mdhs.unimelb.edu.au/pub/mtrflatfile_1.0.txt.gz.tbi - perl variant_effect_predictor.pl -i variations.vcf --plugin MTR,mtrflatfile_1.0.txt.gz - -=head1 DESCRIPTION - -A VEP plugin that retrieves Missense Tolerance Ratio (MTR) scores for -variants from a tabix-indexed flat file. - -MTR scores quantify the amount of purifying selection acting -specifically on missense variants in a given window of protein-coding -sequence. It is estimated across a sliding window of 31 codons and uses -observed standing variation data from the WES component of the Exome -Aggregation Consortium Database (ExAC), version 2.0 -(http://gnomad.broadinstitute.org). - -Please cite the MTR publication alongside the VEP if you use this resource: -http://genome.cshlp.org/content/27/10/1715 - -The Bio::DB::HTS perl library or tabix utility must be installed in your path -to use this plugin. MTR flat files can be downloaded from: -ftp://mtr-viewer.mdhs.unimelb.edu.au/pub - -NB: Data are available for GRCh37 only - -=cut - -package MTR; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -sub new { - my $class = shift; - my $self = $class->SUPER::new(@_); - - # test tabix - die "ERROR: tabix does not seem to be in your path\n" unless `which tabix 2>&1` =~ /tabix$/; - - # get MTR file - my $file = $self->params->[0]; - $self->add_file($file); - - # remote files? - if($file =~ /tp\:\/\//) { - my $remote_test = `tabix -f $file 1:1-1 2>&1`; - if($remote_test && $remote_test !~ /get_local_version/) { - die "$remote_test\nERROR: Could not find file or index file for remote annotation file $file\n"; - } - } - - # check files exist - else { - die "ERROR: MTR file $file not found\n" unless -e $file; - die "ERROR: Tabix index file $file\.tbi not found - perhaps you need to create it first?\n" unless -e $file.'.tbi'; - } - - # get headers and store on self - open HEAD, "tabix -fh $file 1:1-1 2>&1 | "; - while(<HEAD>) { - next unless /^\#/; - chomp; - $self->{headers} = [split]; - } - close HEAD; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub variation_feature_types { - return ['VariationFeature']; -} - -sub get_header_info { - my $self = shift; - return { - MTR => 'MTR score', - FDR => 'MTR false discovery rate adjusted binomial exact test.', - MTR_centile => 'MTR gene-specific percentile' - } -} - -sub run { - my ($self, $tva) = @_; - my $vf = $tva->variation_feature; - - # get allele, reverse comp if needed - my $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - return {} unless $allele =~ /^[ACGT]$/; - - my $tr_id = $tva->transcript->stable_id; - - # data is written by pos, allele, transcript ID (feature) - # grep lines read in matched on position so that they also are matched on allele and transcript ID - my ($res) = grep { - $_->{Genomic_position} eq $vf->{start} && - $_->{Genomic_position} eq $vf->{end} && - $_->{alt} eq $allele && - $_->{Feature} eq $tr_id - } @{$self->get_data($vf->{chr}, $vf->{start}, $vf->{end})}; - - # return only the keys defined by get_header_info() - return $res ? { map {$_ => $res->{$_}} grep {defined($res->{$_}) && $res->{$_} ne '.'} keys %{$self->get_header_info} } : {}; -} - -sub parse_data { - my ($self, $line) = @_; - - $line =~ s/\r$//g; - - my @split = split /\t/, $line; - - # parse data into hash of col names and values - my %data = map {$self->{headers}->[$_] => $split[$_]} (0..(scalar @{$self->{headers}} - 1)); - - return \%data; -} - -sub get_start { - return $_[1]->{'Genomic_position'}; -} - -sub get_end { - return $_[1]->{'Genomic_position'}; -} - -1;
--- a/dir_plugins/MaxEntScan.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,895 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - MaxEntScan - -=head1 SYNOPSIS - - mv MaxEntScan.pm ~/.vep/Plugins - ./vep -i variants.vcf --plugin MaxEntScan,/path/to/maxentscan/fordownload - ./vep -i variants.vcf --plugin MaxEntScan,/path/to/maxentscan/fordownload,SWA,NCSS - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - runs MaxEntScan (http://genes.mit.edu/burgelab/maxent/Xmaxentscan_scoreseq.html) - to get splice site predictions. - - The plugin copies most of the code verbatim from the score5.pl and score3.pl - scripts provided in the MaxEntScan download. To run the plugin you must get and - unpack the archive from http://genes.mit.edu/burgelab/maxent/download/; the path - to this unpacked directory is then the param you pass to the --plugin flag. - - The plugin executes the logic from one of the scripts depending on which - splice region the variant overlaps: - - score5.pl : last 3 bases of exon --> first 6 bases of intron - score3.pl : last 20 bases of intron --> first 3 bases of exon - - The plugin reports the reference, alternate and difference (REF - ALT) maximum - entropy scores. - - If 'SWA' is specified as a command-line argument, a sliding window algorithm - is applied to subsequences containing the reference and alternate alleles to - identify k-mers with the highest donor and acceptor splice site scores. To assess - the impact of variants, reference comparison scores are also provided. For SNVs, - the comparison scores are derived from sequence in the same frame as the highest - scoring k-mers containing the alternate allele. For all other variants, the - comparison scores are derived from the highest scoring k-mers containing the - reference allele. The difference between the reference comparison and alternate - scores (SWA_REF_COMP - SWA_ALT) are also provided. - - If 'NCSS' is specified as a command-line argument, scores for the nearest - upstream and downstream canonical splice sites are also included. - - By default, only scores are reported. Add 'verbose' to the list of command- - line arguments to include the sequence output associated with those scores. - -=cut - -package MaxEntScan; - -use strict; -use warnings; - -use Digest::MD5 qw(md5_hex); - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); -use Bio::EnsEMBL::Variation::Utils::VariationEffect qw(overlap); - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -# how many seq/score pairs to cache in memory -our $CACHE_SIZE = 50; - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - # we need sequence, so no offline mode unless we have FASTA - die("ERROR: cannot function in offline mode without a FASTA file\n") if $self->{config}->{offline} && !$self->{config}->{fasta}; - - my $params = $self->params; - - my $dir = shift @$params; - die("ERROR: MaxEntScan directory not specified\n") unless $dir; - die("ERROR: MaxEntScan directory not found\n") unless -d $dir; - $self->{_dir} = $dir; - - ## setup from score5.pl - $self->{'score5_me2x5'} = $self->score5_makescorematrix($dir.'/me2x5'); - $self->{'score5_seq'} = $self->score5_makesequencematrix($dir.'/splicemodels/splice5sequences'); - - ## setup from score3.pl - $self->{'score3_metables'} = $self->score3_makemaxentscores; - - my %opts = map { $_ => undef } @$params; - - $self->{'run_SWA'} = 1 if exists $opts{'SWA'}; - $self->{'run_NCSS'} = 1 if exists $opts{'NCSS'}; - - $self->{'verbose'} = 1 if exists $opts{'verbose'}; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - my $self = shift; - - my $v = $self->{'verbose'}; - my $headers = $self->get_MES_header_info($v); - - if ($self->{'run_SWA'}) { - my $swa_headers = $self->get_SWA_header_info($v); - $headers = {%$headers, %$swa_headers}; - } - - if ($self->{'run_NCSS'}) { - my $ncss_headers = $self->get_NCSS_header_info($v); - $headers = {%$headers, %$ncss_headers}; - } - - return $headers; -} - -sub get_MES_header_info { - my ($self, $verbose) = @_; - - my $headers = { - MaxEntScan_ref => "MaxEntScan reference sequence score", - MaxEntScan_alt => "MaxEntScan alternate sequence score", - MaxEntScan_diff => "MaxEntScan score difference", - }; - - if ($verbose) { - - $headers->{'MaxEntScan_ref_seq'} = "MaxEntScan reference sequence"; - $headers->{'MaxEntScan_alt_seq'} = "MaxEntScan alternate sequence"; - } - - return $headers; -} - -sub get_SWA_header_info { - my ($self, $verbose) = @_; - - my $headers = { - "MES-SWA_donor_ref" => "Highest splice donor reference sequence score", - "MES-SWA_donor_alt" => "Highest splice donor alternate sequence score", - "MES-SWA_donor_ref_comp" => "Donor reference comparison sequence score", - "MES-SWA_donor_diff" => "Difference between the donor reference comparison and alternate sequence scores", - - "MES-SWA_acceptor_ref" => "Highest splice acceptor reference sequence score", - "MES-SWA_acceptor_alt" => "Highest splice acceptor alternate sequence score", - "MES-SWA_acceptor_ref_comp" => "Acceptor reference comparison sequence score", - "MES-SWA_acceptor_diff" => "Difference between the acceptor reference comparison and alternate sequence scores", - }; - - if ($verbose) { - - $headers->{'MES-SWA_donor_ref_seq'} = "Highest splice donor reference sequence"; - $headers->{'MES-SWA_donor_ref_frame'} = "Position of the highest splice donor reference sequence"; - $headers->{'MES-SWA_donor_ref_context'} = "Selected donor sequence context containing the reference allele"; - $headers->{'MES-SWA_donor_alt_seq'} = "Highest splice donor alternate sequence"; - $headers->{'MES-SWA_donor_alt_frame'} = "Position of the highest splice donor alternate sequence"; - $headers->{'MES-SWA_donor_alt_context'} = "Selected donor sequence context containing the alternate allele"; - $headers->{'MES-SWA_donor_ref_comp_seq'} = "Donor reference comparison sequence"; - - $headers->{'MES-SWA_acceptor_ref_seq'} = "Highest splice acceptor reference sequence"; - $headers->{'MES-SWA_acceptor_ref_frame'} = "Position of the highest splice acceptor reference sequence"; - $headers->{'MES-SWA_acceptor_ref_context'} = "Selected acceptor sequence context containing the reference allele"; - $headers->{'MES-SWA_acceptor_alt_seq'} = "Highest splice acceptor alternate sequence"; - $headers->{'MES-SWA_acceptor_alt_frame'} = "Position of the highest splice acceptor alternate sequence"; - $headers->{'MES-SWA_acceptor_alt_context'} = "Selected acceptor sequence context containing the alternate allele"; - $headers->{'MES-SWA_acceptor_ref_comp_seq'} = "Acceptor reference comparison sequence"; - } - - return $headers; -} - -sub get_NCSS_header_info { - my ($self, $verbose) = @_; - - my $headers = { - "MES-NCSS_upstream_acceptor" => "Nearest upstream canonical splice acceptor sequence score", - "MES-NCSS_upstream_donor" => "Nearest upstream canonical splice donor sequence score", - - "MES-NCSS_downstream_acceptor" => "Nearest downstream canonical splice acceptor sequence score", - "MES-NCSS_downstream_donor" => "Nearest downstream canonical splice donor sequence score", - }; - - if ($verbose) { - - $headers->{'MES-NCSS_upstream_acceptor_seq'} = "Nearest upstream canonical splice acceptor sequence"; - $headers->{'MES-NCSS_upstream_donor_seq'} = "Nearest upstream canonical splice donor sequence"; - - $headers->{'MES-NCSS_downstream_acceptor_seq'} = "Nearest downstream canonical splice acceptor sequence"; - $headers->{'MES-NCSS_downstream_donor_seq'} = "Nearest downstream canonical splice donor sequence"; - } - - return $headers; -} - -sub run { - my ($self, $tva) = @_; - - my $seq_headers = $self->get_MES_header_info(); - my $results = $self->run_MES($tva); - - if ($self->{'run_SWA'}) { - my $swa_seq_headers = $self->get_SWA_header_info(); - $seq_headers = {%$seq_headers, %$swa_seq_headers}; - my $swa_results = $self->run_SWA($tva); - $results = {%$results, %$swa_results}; - } - - if ($self->{'run_NCSS'}) { - my $ncss_seq_headers = $self->get_NCSS_header_info(); - $seq_headers = {%$seq_headers, %$ncss_seq_headers}; - my $ncss_results = $self->run_NCSS($tva); - $results = {%$results, %$ncss_results}; - } - - my %data; - - # add the scores - my @scores = grep { exists $results->{$_} } keys %$seq_headers; - @data{@scores} = map { sprintf('%.3f', $_) } @{$results}{@scores}; - - if ($self->{'verbose'}) { - # add any remaining results - my @non_scores = grep { ! exists $data{$_} } keys %$results; - @data{@non_scores} = @{$results}{@non_scores}; - } - - return \%data; -} - -sub run_MES { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - return {} unless $vf->{start} == $vf->{end} && $tva->feature_seq =~ /^[ACGT]$/; - - my $tv = $tva->transcript_variation; - my $tr = $tva->transcript; - my $tr_strand = $tr->strand; - my ($vf_start, $vf_end) = ($vf->start, $vf->end); - - # use _overlapped_introns() method from BaseTranscriptVariation - # this will use an interval tree if available for superfast lookup of overlapping introns - # we have to expand the search space around $vf because we're looking for the splice region not the intron per se - foreach my $intron(@{$tv->_overlapped_introns($vf_start - 21, $vf_end + 21)}) { - - # get coords depending on strand - # MaxEntScan does different predictions for 5 and 3 prime - # and we need to feed it different bits of sequence for each - # - # 5prime, 3 bases of exon, 6 bases of intron: - # ===------ - # - # 3prime, 20 bases of intron, 3 bases of exon - # --------------------=== - - my ($five_start, $five_end, $three_start, $three_end); - - if($tr_strand > 0) { - ($five_start, $five_end) = ($intron->start - 3, $intron->start + 5); - ($three_start, $three_end) = ($intron->end - 19, $intron->end + 3); - } - - else { - ($five_start, $five_end) = ($intron->end - 5, $intron->end + 3); - ($three_start, $three_end) = ($intron->start - 3, $intron->start + 19); - } - - if(overlap($vf->start, $vf->end, $five_start, $five_end)) { - my ($ref_seq, $alt_seq) = @{$self->get_seqs($tva, $five_start, $five_end)}; - - return {} unless defined($ref_seq) && $ref_seq =~ /^[ACGT]+$/; - return {} unless defined($alt_seq) && $alt_seq =~ /^[ACGT]+$/; - - my $ref_score = $self->score5($ref_seq); - my $alt_score = $self->score5($alt_seq); - - return { - MaxEntScan_ref => $ref_score, - MaxEntScan_ref_seq => $ref_seq, - MaxEntScan_alt => $alt_score, - MaxEntScan_alt_seq => $alt_seq, - MaxEntScan_diff => $ref_score - $alt_score, - } - } - - if(overlap($vf->start, $vf->end, $three_start, $three_end)) { - my ($ref_seq, $alt_seq) = @{$self->get_seqs($tva, $three_start, $three_end)}; - - return {} unless defined($ref_seq) && $ref_seq =~ /^[ACGT]+$/; - return {} unless defined($alt_seq) && $alt_seq =~ /^[ACGT]+$/; - - my $ref_score = $self->score3($ref_seq); - my $alt_score = $self->score3($alt_seq); - - return { - MaxEntScan_ref => $ref_score, - MaxEntScan_ref_seq => $ref_seq, - MaxEntScan_alt => $alt_score, - MaxEntScan_alt_seq => $alt_seq, - MaxEntScan_diff => $ref_score - $alt_score, - } - } - } - - return {}; -} - -sub run_SWA { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - my %results; - - # get the donor reference and alternate sequence contexts - my ($donor_ref_context, $donor_alt_context) = @{$self->get_seqs($tva, $vf->start - 8, $vf->end + 8)}; - - if (defined($donor_ref_context)) { - $results{'MES-SWA_donor_ref_context'} = $donor_ref_context; - - if ($donor_ref_context =~ /^[ACGT]+$/) { - my ($seq, $frame, $score) = @{$self->get_max_donor($donor_ref_context)}; - $results{'MES-SWA_donor_ref_seq'} = $seq; - $results{'MES-SWA_donor_ref_frame'} = $frame; - $results{'MES-SWA_donor_ref'} = $score; - } - } - - if (defined($donor_alt_context)) { - $results{'MES-SWA_donor_alt_context'} = $donor_alt_context; - - if ($donor_alt_context =~ /^[ACGT]+$/) { - my ($seq, $frame, $score) = @{$self->get_max_donor($donor_alt_context)}; - $results{'MES-SWA_donor_alt_seq'} = $seq; - $results{'MES-SWA_donor_alt_frame'} = $frame; - $results{'MES-SWA_donor_alt'} = $score; - - if (defined(my $ref_comp_seq = $results{'MES-SWA_donor_ref_seq'})) { - - if ($vf->{start} == $vf->{end} && $tva->feature_seq =~ /^[ACGT]$/) { - # for SNVs, compare to the same frame as the highest scoring ALT k-mer - $ref_comp_seq = substr($donor_ref_context, $frame - 1, 9); - } - - $results{'MES-SWA_donor_ref_comp_seq'} = $ref_comp_seq; - $results{'MES-SWA_donor_ref_comp'} = $self->score5($ref_comp_seq); - - $results{'MES-SWA_donor_diff'} = $results{'MES-SWA_donor_ref_comp'} - $score; - } - } - } - - # get the acceptor reference and alternate sequence contexts - my ($acceptor_ref_context, $acceptor_alt_context) = @{$self->get_seqs($tva, $vf->start - 22, $vf->end + 22)}; - - if (defined($acceptor_ref_context)) { - $results{'MES-SWA_acceptor_ref_context'} = $acceptor_ref_context; - - if ($acceptor_ref_context =~ /^[ACGT]+$/) { - my ($seq, $frame, $score) = @{$self->get_max_acceptor($acceptor_ref_context)}; - $results{'MES-SWA_acceptor_ref_seq'} = $seq; - $results{'MES-SWA_acceptor_ref_frame'} = $frame; - $results{'MES-SWA_acceptor_ref'} = $score; - } - } - - if (defined($acceptor_alt_context)) { - $results{'MES-SWA_acceptor_alt_context'} = $acceptor_alt_context; - - if ($acceptor_alt_context =~ /^[ACGT]+$/) { - my ($seq, $frame, $score) = @{$self->get_max_acceptor($acceptor_alt_context)}; - $results{'MES-SWA_acceptor_alt_seq'} = $seq; - $results{'MES-SWA_acceptor_alt_frame'} = $frame; - $results{'MES-SWA_acceptor_alt'} = $score; - - if (defined(my $ref_comp_seq = $results{'MES-SWA_acceptor_ref_seq'})) { - - if ($vf->{start} == $vf->{end} && $tva->feature_seq =~ /^[ACGT]$/) { - # for SNVs, compare to the same frame as the highest scoring ALT k-mer - $ref_comp_seq = substr($acceptor_ref_context, $frame - 1, 23); - } - - $results{'MES-SWA_acceptor_ref_comp_seq'} = $ref_comp_seq; - $results{'MES-SWA_acceptor_ref_comp'} = $self->score3($ref_comp_seq); - - $results{'MES-SWA_acceptor_diff'} = $results{'MES-SWA_acceptor_ref_comp'} - $score; - } - } - } - - return \%results; -} - -sub run_NCSS { - my ($self, $tva) = @_; - - my $tv = $tva->transcript_variation; - my $tr = $tva->transcript; - - my %results; - - if ($tv->intron_number) { - - my ($intron_numbers, $total_introns) = split(/\//, $tv->intron_number); - my $intron_number = (split(/-/, $intron_numbers))[0]; - - my $introns = $tr->get_all_Introns; - - my $intron_idx = $intron_number - 1; - my $intron = $introns->[$intron_idx]; - - if (defined(my $seq = $self->get_donor_seq_from_intron($intron))) { - $results{'MES-NCSS_upstream_donor_seq'} = $seq; - $results{'MES-NCSS_upstream_donor'} = $self->score5($seq) if $seq =~ /^[ACGT]+$/; - } - - if (defined(my $seq = $self->get_acceptor_seq_from_intron($intron))) { - $results{'MES-NCSS_downstream_acceptor_seq'} = $seq; - $results{'MES-NCSS_downstream_acceptor'} = $self->score3($seq) if $seq =~ /^[ACGT]+$/; - } - - # don't calculate an upstream acceptor score if the intron is the first in the transcript - unless ($intron_number == 1) { - my $upstream_intron = $introns->[$intron_idx - 1]; - - if (defined(my $seq = $self->get_acceptor_seq_from_intron($upstream_intron))) { - $results{'MES-NCSS_upstream_acceptor_seq'} = $seq; - $results{'MES-NCSS_upstream_acceptor'} = $self->score3($seq) if $seq =~ /^[ACGT]+$/; - } - } - - # don't calculate a downstream donor score if the intron is the last in the transcript - unless ($intron_number == $total_introns) { - my $downstream_intron = $introns->[$intron_idx + 1]; - - if (defined(my $seq = $self->get_donor_seq_from_intron($downstream_intron))) { - $results{'MES-NCSS_downstream_donor_seq'} = $seq; - $results{'MES-NCSS_downstream_donor'} = $self->score5($seq) if $seq =~ /^[ACGT]+$/; - } - } - } - - elsif ($tv->exon_number) { - - my ($exon_numbers, $total_exons) = split(/\//, $tv->exon_number); - my $exon_number = (split(/-/, $exon_numbers))[0]; - - my $exons = $tr->get_all_Exons; - - my $exon_idx = $exon_number - 1; - my $exon = $exons->[$exon_idx]; - - # don't calculate upstream scores if the exon is the first in the transcript - unless ($exon_number == 1) { - my $upstream_exon = $exons->[$exon_idx - 1]; - - if (defined(my $seq = $self->get_donor_seq_from_exon($upstream_exon))) { - $results{'MES-NCSS_upstream_donor_seq'} = $seq; - $results{'MES-NCSS_upstream_donor'} = $self->score5($seq) if $seq =~ /^[ACGT]+$/; - } - - if (defined(my $seq = $self->get_acceptor_seq_from_exon($exon))) { - $results{'MES-NCSS_upstream_acceptor_seq'} = $seq; - $results{'MES-NCSS_upstream_acceptor'} = $self->score3($seq) if $seq =~ /^[ACGT]+$/; - } - } - - # don't calculate downstream scores if the exon is the last exon in the transcript - unless ($exon_number == $total_exons) { - my $downstream_exon = $exons->[$exon_idx + 1]; - - if (defined(my $seq = $self->get_donor_seq_from_exon($exon))) { - $results{'MES-NCSS_downstream_donor_seq'} = $seq; - $results{'MES-NCSS_downstream_donor'} = $self->score5($seq) if $seq =~ /^[ACGT]+$/; - } - - if (defined(my $seq = $self->get_acceptor_seq_from_exon($downstream_exon))) { - $results{'MES-NCSS_downstream_acceptor_seq'} = $seq; - $results{'MES-NCSS_downstream_acceptor'} = $self->score3($seq) if $seq =~ /^[ACGT]+$/; - } - } - } - - return \%results; -} - - -## Sliding window approach methods -################################## - -sub get_max_donor { - my ($self, $sequence) = @_; - - my ($seq, $frame, $max); - my @kmers = @{$self->sliding_window($sequence, 9)}; - - for my $i (0 .. $#kmers) { - my $kmer = $kmers[$i]; - my $score = $self->score5($kmer); - if(!$max || $score > $max) { - $seq = $kmer; - $frame = $i + 1; - $max = $score; - } - } - return [$seq, $frame, $max]; -} - -sub get_max_acceptor { - my ($self, $sequence) = @_; - - my ($seq, $frame, $max); - my @kmers = @{$self->sliding_window($sequence, 23)}; - - for my $i (0 .. $#kmers) { - my $kmer = $kmers[$i]; - my $score = $self->score3($kmer); - if(!$max || $score > $max) { - $seq = $kmer; - $frame = $i + 1; - $max = $score; - } - } - return [$seq, $frame, $max]; -} - -sub sliding_window { - my ($self, $sequence, $winsize) = @_; - my @seqs; - for (my $i = 1; $i <= length($sequence) - $winsize + 1; $i++) { - push @seqs, substr($sequence, $i - 1, $winsize); - } - return \@seqs; -} - - -## Nearest canonical splice site methods -######################################## - -sub get_donor_seq_from_exon { - my ($self, $exon) = @_; - - my ($start, $end); - - if ($exon->strand > 0) { - ($start, $end) = ($exon->end - 2, $exon->end + 6); - } - else { - ($start, $end) = ($exon->start - 6, $exon->start + 2); - } - - my $slice = $exon->slice()->sub_Slice($start, $end, $exon->strand); - my $seq = $slice->seq() if defined($slice); - - return $seq; -} - -sub get_acceptor_seq_from_exon { - my ($self, $exon) = @_; - - my ($start, $end); - - if ($exon->strand > 0) { - ($start, $end) = ($exon->start - 20, $exon->start + 2); - } - else { - ($start, $end) = ($exon->end - 2, $exon->end + 20); - } - - my $slice = $exon->slice()->sub_Slice($start, $end, $exon->strand); - my $seq = $slice->seq() if defined($slice); - - return $seq; -} - -sub get_donor_seq_from_intron { - my ($self, $intron) = @_; - - my ($start, $end); - - if ($intron->strand > 0) { - ($start, $end) = ($intron->start - 3, $intron->start + 5); - } - else { - ($start, $end) = ($intron->end - 5, $intron->end + 3); - } - - my $slice = $intron->slice()->sub_Slice($start, $end, $intron->strand); - my $seq = $slice->seq() if defined($slice); - - return $seq; -} - -sub get_acceptor_seq_from_intron { - my ($self, $intron) = @_; - - my ($start, $end); - - if ($intron->strand > 0) { - ($start, $end) = ($intron->end - 19, $intron->end + 3); - } - else { - ($start, $end) = ($intron->start - 3, $intron->start + 19); - } - - my $slice = $intron->slice()->sub_Slice($start, $end, $intron->strand); - my $seq = $slice->seq() if defined($slice); - - return $seq; -} - - -## Common methods -################# - -sub get_seqs { - my ($self, $tva, $start, $end) = @_; - my $vf = $tva->variation_feature; - - my $tr_strand = $tva->transcript->strand; - - my $ref_slice = $vf->{slice}->sub_Slice($start, $end, $tr_strand); - - my ($ref_seq, $alt_seq); - - if (defined $ref_slice) { - - $ref_seq = $alt_seq = $ref_slice->seq(); - - my $substr_start = $tr_strand > 0 ? $vf->{start} - $start : $end - $vf->{end}; - my $feature_seq = $tva->seq_length > 0 ? $tva->feature_seq : ''; - - substr($alt_seq, $substr_start, ($vf->{end} - $vf->{start}) + 1) = $feature_seq; - } - - return [$ref_seq, $alt_seq]; -} - -sub score5 { - my $self = shift; - my $seq = shift; - my $hex = md5_hex($seq); - - # check cache - if($self->{cache}) { - my ($res) = grep {$_->{hex} eq $hex} @{$self->{cache}->{score5}}; - - return $res->{score} if $res; - } - - my $a = $self->score5_scoreconsensus($seq); - die("ERROR: No score5_scoreconsensus\n") unless defined($a); - - my $b = $self->score5_getrest($seq); - die("ERROR: No score5_getrest\n") unless defined($b); - - my $c = $self->{'score5_seq'}->{$b}; - die("ERROR: No score5_seq for $b\n") unless defined($c); - - my $d = $self->{'score5_me2x5'}->{$c}; - die("ERROR: No score5_me2x5 for $c\n") unless defined($d); - - my $score = $self->log2($a * $d); - - # cache it - push @{$self->{cache}->{score5}}, { hex => $hex, score => $score }; - shift @{$self->{cache}->{score5}} while scalar @{$self->{cache}->{score5}} > $CACHE_SIZE; - - return $score; -} - -sub score3 { - my $self = shift; - my $seq = shift; - my $hex = md5_hex($seq); - - # check cache - if($self->{cache}) { - my ($res) = grep {$_->{hex} eq $hex} @{$self->{cache}->{score3}}; - - return $res->{score} if $res; - } - - my $a = $self->score3_scoreconsensus($seq); - die("ERROR: No score3_scoreconsensus\n") unless defined($a); - - my $b = $self->score3_getrest($seq); - die("ERROR: No score3_getrest\n") unless defined($b); - - my $c = $self->score3_maxentscore($b, $self->{'score3_metables'}); - die("ERROR: No score3_maxentscore for $b\n") unless defined($c); - - my $score = $self->log2($a * $c); - - # cache it - push @{$self->{cache}->{score3}}, { hex => $hex, score => $score }; - shift @{$self->{cache}->{score3}} while scalar @{$self->{cache}->{score3}} > $CACHE_SIZE; - - return $score; -} - - -## methods copied from score5.pl -################################ - -sub score5_makesequencematrix { - my $self = shift; - my $file = shift; - my %matrix; - my $n=0; - open(SCOREF, $file) || die "Can't open $file!\n"; - while(<SCOREF>) { - chomp; - $_=~ s/\s//; - $matrix{$_} = $n; - $n++; - } - close(SCOREF); - return \%matrix; -} - -sub score5_makescorematrix { - my $self = shift; - my $file = shift; - my %matrix; - my $n=0; - open(SCOREF, $file) || die "Can't open $file!\n"; - while(<SCOREF>) { - chomp; - $_=~ s/\s//; - $matrix{$n} = $_; - $n++; - } - close(SCOREF); - return \%matrix; -} - -sub score5_getrest { - my $self = shift; - my $seq = shift; - my @seqa = split(//,uc($seq)); - return $seqa[0].$seqa[1].$seqa[2].$seqa[5].$seqa[6].$seqa[7].$seqa[8]; -} - -sub score5_scoreconsensus { - my $self = shift; - my $seq = shift; - my @seqa = split(//,uc($seq)); - my %bgd; - $bgd{'A'} = 0.27; - $bgd{'C'} = 0.23; - $bgd{'G'} = 0.23; - $bgd{'T'} = 0.27; - my %cons1; - $cons1{'A'} = 0.004; - $cons1{'C'} = 0.0032; - $cons1{'G'} = 0.9896; - $cons1{'T'} = 0.0032; - my %cons2; - $cons2{'A'} = 0.0034; - $cons2{'C'} = 0.0039; - $cons2{'G'} = 0.0042; - $cons2{'T'} = 0.9884; - my $addscore = $cons1{$seqa[3]}*$cons2{$seqa[4]}/($bgd{$seqa[3]}*$bgd{$seqa[4]}); - return $addscore; -} - -sub log2 { - my ($self, $val) = @_; - return log($val)/log(2); -} - - -## methods copied from score3.pl -################################ - -sub score3_hashseq { - #returns hash of sequence in base 4 - # $self->score3_hashseq('CAGAAGT') returns 4619 - my $self = shift; - my $seq = shift; - $seq = uc($seq); - $seq =~ tr/ACGT/0123/; - my @seqa = split(//,$seq); - my $sum = 0; - my $len = length($seq); - my @four = (1,4,16,64,256,1024,4096,16384); - my $i=0; - while ($i<$len) { - $sum+= $seqa[$i] * $four[$len - $i -1] ; - $i++; - } - return $sum; -} - -sub score3_makemaxentscores { - my $self = shift; - my $dir = $self->{'_dir'}."/splicemodels/"; - my @list = ('me2x3acc1','me2x3acc2','me2x3acc3','me2x3acc4', - 'me2x3acc5','me2x3acc6','me2x3acc7','me2x3acc8','me2x3acc9'); - my @metables; - my $num = 0 ; - foreach my $file (@list) { - my $n = 0; - open (SCOREF,"<".$dir.$file) || die "Can't open $file!\n"; - while(<SCOREF>) { - chomp; - $_=~ s/\s//; - $metables[$num]{$n} = $_; - $n++; - } - close(SCOREF); - #print STDERR $file."\t".$num."\t".$n."\n"; - $num++; - } - return \@metables; -} - -sub score3_maxentscore { - my $self = shift; - my $seq = shift; - my $table_ref = shift; - my @metables = @$table_ref; - my @sc; - $sc[0] = $metables[0]{$self->score3_hashseq(substr($seq,0,7))}; - $sc[1] = $metables[1]{$self->score3_hashseq(substr($seq,7,7))}; - $sc[2] = $metables[2]{$self->score3_hashseq(substr($seq,14,7))}; - $sc[3] = $metables[3]{$self->score3_hashseq(substr($seq,4,7))}; - $sc[4] = $metables[4]{$self->score3_hashseq(substr($seq,11,7))}; - $sc[5] = $metables[5]{$self->score3_hashseq(substr($seq,4,3))}; - $sc[6] = $metables[6]{$self->score3_hashseq(substr($seq,7,4))}; - $sc[7] = $metables[7]{$self->score3_hashseq(substr($seq,11,3))}; - $sc[8] = $metables[8]{$self->score3_hashseq(substr($seq,14,4))}; - my $finalscore = $sc[0] * $sc[1] * $sc[2] * $sc[3] * $sc[4] / ($sc[5] * $sc[6] * $sc[7] * $sc[8]); - return $finalscore; -} - -sub score3_getrest { - my $self = shift; - my $seq = shift; - my $seq_noconsensus = substr($seq,0,18).substr($seq,20,3); - return $seq_noconsensus; -} - -sub score3_scoreconsensus { - my $self = shift; - my $seq = shift; - my @seqa = split(//,uc($seq)); - my %bgd; - $bgd{'A'} = 0.27; - $bgd{'C'} = 0.23; - $bgd{'G'} = 0.23; - $bgd{'T'} = 0.27; - my %cons1; - $cons1{'A'} = 0.9903; - $cons1{'C'} = 0.0032; - $cons1{'G'} = 0.0034; - $cons1{'T'} = 0.0030; - my %cons2; - $cons2{'A'} = 0.0027; - $cons2{'C'} = 0.0037; - $cons2{'G'} = 0.9905; - $cons2{'T'} = 0.0030; - my $addscore = $cons1{$seqa[18]} * $cons2{$seqa[19]}/ ($bgd{$seqa[18]} * $bgd{$seqa[19]}); - return $addscore; -} - -1; -
--- a/dir_plugins/NearestGene.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,122 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - NearestGene - -=head1 SYNOPSIS - - mv NearestGene.pm ~/.vep/Plugins - ./vep -i variations.vcf --cache --plugin NearestGene - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - finds the nearest gene(s) to a non-genic variant. More than one gene - may be reported if the genes overlap the variant or if genes are - equidistant. - - Various parameters can be altered by passing them to the plugin command: - - - limit : limit the number of genes returned (default: 1) - - range : initial search range in bp (default: 1000) - - max_range : maximum search range in bp (default: 10000) - - Parameters are passed e.g.: - - --plugin NearestGene,limit=3,max_range=50000 - -=cut - -package NearestGene; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -my %CONFIG = ( - limit => 1, - range => 1000, - max_range => 10000, -); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $params = $self->params; - - foreach my $param(@$params) { - my ($key, $val) = split('=', $param); - die("ERROR: Failed to parse parameter $param\n") unless defined($key) && defined($val); - $CONFIG{$key} = $val; - } - - return $self; -} - -sub feature_types { - return ['Intergenic','MotifFeature','RegulatoryFeature']; -} - -sub variant_feature_types { - return ['BaseVariationFeature']; -} - -sub get_header_info { - return { - NearestGene => "Ensembl identifier of nearest gene" - }; -} - -sub run { - my ($self, $vfoa) = @_; - - my $vf = $vfoa->base_variation_feature; - my $loc_string = sprintf("%s:%i-%i", $vf->{chr} || $vf->seq_region_name, $vf->{start}, $vf->{end}); - - if(!exists($self->{_cache}) || !exists($self->{_cache}->{$loc_string})) { - $self->{config}->{ga} = $self->{config}->{reg}->get_adaptor($self->{config}->{species}, $self->{config}->{core_type}, 'gene'); - $self->{ga} ||= $self->{config}->{ga}; - die("ERROR: Could not get gene adaptor; this plugin does not work in --offline mode\n") unless $self->{ga}; - - my %opts = map {'-'.$_ => $CONFIG{$_}} keys %CONFIG; - $opts{-feature} = $vf; - - my @result = map {$_->[0]->stable_id} @{ - $self->{ga}->fetch_all_by_outward_search(%opts) - }; - - $self->{_cache}->{$loc_string} = scalar @result ? join(",", @result) : undef; - } - - return $self->{_cache}->{$loc_string} ? { NearestGene => $self->{_cache}->{$loc_string} } : {}; -} - -1; -
--- a/dir_plugins/NonSynonymousFilter.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,65 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - NonSynonymousFilter - -=head1 SYNOPSIS - - mv NonSynonymousFilter.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin NonSynonymousFilter - -=head1 DESCRIPTION - - A simple example VEP filter plugin that limits output to non-synonymous variants - -=cut - -package NonSynonymousFilter; - -use strict; -use warnings; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepFilterPlugin); - -sub feature_types { - return ['Transcript']; -} - -sub include_line { - my ($self, $tva) = @_; - - # just check if there are alternative amino acids in the - # pep_allele_string, this means we'll catch stop gained - # or lost as well - - if (my $pep_alleles = $tva->pep_allele_string) { - return $pep_alleles =~ /\//; - } - - return 0; -} - -1; -
--- a/dir_plugins/PON_P2.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,107 +0,0 @@ -=head1 NAME - PON_P2 - -=head1 SYNOPSIS - mv PON_P2.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin PON_P2,/path/to/python/script/ponp2.py,hg37 - -=head1 DESCRIPTION - This plugin for Ensembl Variant Effect Predictor (VEP) computes the predictions of PON-P2 - for amino acid substitutions in human proteins. PON-P2 is developed and maintained by - Protein Structure and Bioinformatics Group at Lund University and is available at - http://structure.bmc.lu.se/PON-P2/. - - To run this plugin, you will require a python script and its dependencies (Python, - python suds). The python file can be downloaded from http://structure.bmc.lu.se/PON-P2/vep.html/ - and the complete path to this file must be supplied while using this plugin. - -=head1 CONTACT -Abhishek Niroula <abhishek.niroula@med.lu.se> -Mauno Vihinen <mauno.vihinen@med.lu.se> - -=cut - -package PON_P2; - - -use strict; -use warnings; - - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - - -sub feature_types { - return ['Transcript']; -} - - -sub get_header_info { - return { - PON_P2 => "PON-P2 prediction and score for amino acid substitutions" - }; -} - - -sub new { - my $class = shift; - my $self = $class->SUPER::new(@_); - # get parameters - my $command = $self->params->[0]; - my $Hg = $self->params->[1]; - die 'ERROR: Path to python script not specified! Specify path to python script e.g. --plugin PON_P2,/path/to/python/client/for/ponp2.py,[hg37/hg38]\n' unless defined($command); - die 'ERROR: Reference genome not specified! Specify the reference genome after the path to python file e.g. --plugin PON_P2,/path/to/python/client/for/ponp2.py,[hg37/hg38]\n' unless defined($command); - die "ERROR: Wrong reference genome specified! It should be either 'hg37' or 'hg38'\n" unless ($Hg ~~ ["hg37","hg38"]); - die 'ERROR: Incorrect path to ponp2.py\n' unless -e $command; - $self->{command} = $command; - $self->{Hg} = $Hg; - return $self; -} - - -sub run { - my ($self, $tva) = @_; - - # only for missense variants - return {} unless grep {$_->SO_term eq 'missense_variant'} @{$tva->get_all_OverlapConsequences}; - - ## Now get the variation features - my $vf=$tva -> variation_feature; - - ## If not snp return - return {} unless $vf->{start} eq $vf->{end}; - - ## get allele, reverse comp if needed - my $allele = $tva -> variation_feature_seq; - my $Variation = $tva -> hgvs_genomic; - my ($Chr, $Pos, $Alt) = (split /:g.|>/, $Variation)[0,1,2]; - my $Position = substr $Pos, 0, -1; - my $Ref = substr $Pos, -1; - - ## Check for single nucleotide substitution - return {} unless $Ref =~ /^[ACGT]$/; - return {} unless $Alt =~ /^[ACGT]$/; - - my $command = $self -> {command}; - my $Hg = $self -> {Hg}; - my $V = $Chr."_".$Position."_".$Ref."_".$Alt;; - - ## Call pon-p2 python script here - my $ponp2Res = `python $command $V $Hg` or return {}; - $ponp2Res =~ s/\R//g; - - my ($pred, $prob) =split /\t/, $ponp2Res; - - ## Can PON-P2 predict? - return {} if $pred eq "cannot"; - - ## Return predictions - return $pred && $prob ? { - PON_P2 => "$pred($prob)", - } : {}; -} - -1;
--- a/dir_plugins/Phenotypes.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,331 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - Phenotypes - -=head1 SYNOPSIS - - mv Phenotypes.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin Phenotypes - -=head1 DESCRIPTION - - A VEP plugin that retrieves overlapping phenotype information. - - On the first run for each new version/species/assembly will - download a GFF-format dump to ~/.vep/Plugins/ - - Ensembl provides phenotype annotations mapped to a number of genomic - feature types, including genes, variants and QTLs. - - This plugin is best used with JSON output format; the output will be - more verbose and include all available phenotype annotation data and - metadata. - - For other output formats, only a concatenated list of phenotype - description strings is returned. - - Several paramters can be set using a key=value system: - - file : provide a file path, either to create anew from the download - or to point to an existing file - - exclude_sources: exclude sources of phenotype information. By default - HGMD and COSMIC annotations are excluded. See - http://www.ensembl.org/info/genome/variation/sources_phenotype_documentation.html - Separate multiple values with '&' - - include_sources: force include sources, as exclude_sources - - exclude_types : exclude types of features. By default StructuralVariation - and SupportingStructuralVariation annotations are excluded - due to their size. Separate multiple values with '&'. - Valid types: Gene, Variation, QTL, StructuralVariation, - SupportingStructuralVariation, RegulatoryFeature - - include_types : force include types, as exclude_types - - expand_right : sets cache size in bp. By default annotations 100000bp (100kb) - downstream of the initial lookup are cached - - Example: - - --plugin Phenotypes,file=${HOME}/phenotypes.gff.gz,include_types=Gene - -=cut - -package Phenotypes; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -# default config -my %DEFAULTS = ( - exclude_sources => 'HGMD_PUBLIC&COSMIC', - exclude_types => 'StructuralVariation&SupportingStructuralVariation', - expand_right => 100000, -); - -my @FIELDS = qw(seq_region_name source type start end score strand frame attributes comments); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $params_hash = $self->params_to_hash(); - $DEFAULTS{$_} = $params_hash->{$_} for keys %$params_hash; - - unless($DEFAULTS{file}) { - my $pkg = __PACKAGE__; - $pkg .= '.pm'; - - my $config = $self->{config}; - - my $species = $config->{species}; - my $version = $config->{db_version} || 'Bio::EnsEMBL::Registry'->software_version; - my $assembly = $config->{assembly}; - - $DEFAULTS{file} = sprintf("%s_%s_%i_%s.bed.gz", $INC{$pkg}, $species, $version, $assembly); - } - - $self->generate_phenotype_gff($DEFAULTS{file}) if !(-e $DEFAULTS{file}) || (-e $DEFAULTS{file}.'.lock'); - - $self->add_file($DEFAULTS{file}); - - $self->get_user_params(); - - return $self; -} - -sub feature_types { - return ['Feature','Intergenic']; -} - -sub get_header_info { - my $self = shift; - return { - PHENOTYPES => 'Phenotypes associated with overlapping genomic features' - } -} - -sub generate_phenotype_gff { - my ($self, $file) = @_; - - my $config = $self->{config}; - die("ERROR: Unable to generate GFF file in offline mode\n") if $config->{offline}; - - # test bgzip - die "ERROR: bgzip does not seem to be in your path\n" unless `which bgzip 2>&1` =~ /bgzip$/; - - unless($config->{quiet}) { - print STDERR "### Phenotypes plugin: Generating GFF file $file from database\n"; - print STDERR "### Phenotypes plugin: This will take some time but it will only run once per species, assembly and release\n"; - } - - my $pfa = $self->{config}->{reg}->get_adaptor($config->{species}, 'variation', 'phenotypefeature'); - - print STDERR "### Phenotypes plugin: Querying database\n" unless $config->{quiet}; - - my $sth = $pfa->dbc->prepare(qq{ - SELECT - sr.name AS seqname, - REPLACE(s.name, " ", "_") AS source, - pf.type AS feature, - pf.seq_region_start AS start, - pf.seq_region_end AS end, - NULL AS score, - IF(pf.seq_region_strand = 1, '+', '-') AS strand, - NULL AS frame, - CONCAT_WS('; ', - CONCAT('id=', pf.object_id), - CONCAT('phenotype="', REPLACE(p.description, '"', ''), '"'), - GROUP_CONCAT(at.code, "=", concat('"', pfa.value, '"') SEPARATOR '; ') - ) AS attribute - - FROM - seq_region sr, - source s, - phenotype p, - phenotype_feature pf - - LEFT JOIN (phenotype_feature_attrib pfa, attrib_type `at`) - ON ( - pf.phenotype_feature_id = pfa.phenotype_feature_id - AND pfa.attrib_type_id = at.attrib_type_id - ) - - WHERE sr.seq_region_id = pf.seq_region_id - AND s.source_id = pf.source_id - AND pf.phenotype_id = p.phenotype_id - - GROUP BY pf.phenotype_feature_id - ORDER BY pf.seq_region_id, pf.seq_region_start, pf.seq_region_end - }, { mysql_use_result => 1}); - - $sth->execute(); - - print STDERR "### Phenotypes plugin: Writing to file\n" unless $config->{quiet}; - - my $lock = "$file\.lock"; - open LOCK, ">$lock" or die "ERROR: Unable to write to lock file $lock\n"; - print LOCK "1\n"; - close LOCK; - - open OUT, " | bgzip -c > $file" or die "ERROR: Unable to write to file $file\n"; - - while(my $row = $sth->fetchrow_arrayref()) { - print OUT join("\t", map {defined($_) ? $_ : '.'} @$row)."\n"; - } - - close OUT; - - unlink($lock); - - $sth->finish(); - - print STDERR "### Phenotypes plugin: Indexing file with tabix\n" unless $config->{quiet}; - - system("tabix -p gff $file") and die("ERROR: tabix failed\n"); - - print STDERR "### Phenotypes plugin: All done!\n" unless $config->{quiet}; -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - # adjust coords for tabix - my ($s, $e) = ($vf->{start} - 1, $vf->{end}); - - my $data = $self->get_data($vf->{chr}, $s, $e); - - return {} unless $data && scalar @$data; - - return { - PHENOTYPES => $self->{config}->{output_format} eq "json" ? $data : join(",", map {$_->{phenotype} =~ tr/ ;/\_\_/; $_->{phenotype}} @$data) - }; -} - -sub parse_data { - my ($self, $line) = @_; - - my @split = split /\t/, $line; - - my $data; - - # parse split data into hash - for my $i(0..$#split) { - $data->{$FIELDS[$i]} = $split[$i]; - } - - my $inc_sources = $self->include_sources; - if(scalar keys %$inc_sources) { - return undef if $data->{source} && !$inc_sources->{$data->{source}}; - } - else { - return undef if $data->{source} && $self->exclude_sources->{$data->{source}}; - } - - my $inc_types = $self->include_types; - if(scalar keys %$inc_types) { - return undef if $data->{type} && !$inc_types->{$data->{type}}; - } - else { - return undef if $data->{type} && $self->exclude_types->{$data->{type}}; - } - - # parse attributes - if(defined($data->{attributes})) { - $data->{attributes} =~ s/^\s+//g; - - my %attribs; - - foreach my $pair(split /;\s*/, $data->{attributes}) { - my ($key, $value) = split /\=/, $pair; - - next unless defined($key) and defined($value); - - # remove quote marks - $value =~ s/\"//g; - - # avoid overwriting if an attrib key duplicates a main key - $key = 'attrib_'.$key if exists($data->{lc($key)}); - - # lowercase key to reduce chances of mess up! - $data->{lc($key)} = $value; - } - - delete $data->{attributes}; - } - - # delete empty - map {delete $data->{$_}} grep {$data->{$_} eq '.' || $data->{$_} eq ''} keys %$data; - - return $data; -} - -sub get_start { - return $_[1]->{start}; -} - -sub get_end { - return $_[1]->{end}; -} - -sub exclude_sources { - return $_[0]->_generic_inc_exc('exclude_sources'); -} - -sub exclude_types { - return $_[0]->_generic_inc_exc('exclude_types'); -} - -sub include_sources { - return $_[0]->_generic_inc_exc('include_sources'); -} - -sub include_types { - return $_[0]->_generic_inc_exc('include_types'); -} - -sub _generic_inc_exc { - my ($self, $key) = @_; - - if(!exists($self->{'_'.$key})) { - my %exc = map {$_ => 1} split('&', $DEFAULTS{$key} || ''); - $self->{'_'.$key} = \%exc; - } - - return $self->{'_'.$key}; -} - -1; -
--- a/dir_plugins/PolyPhen_SIFT.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,249 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - PolyPhen_SIFT - -=head1 SYNOPSIS - - mv PolyPhen_SIFT.pm ~/.vep/Plugins - ./vep -i variations.vcf -cache --plugin PolyPhen_SIFT - -=head1 DESCRIPTION - - A VEP plugin that retrieves PolyPhen and SIFT predictions from a - locally constructed sqlite database. It can be used when your main - source of VEP transcript annotation (e.g. a GFF file or GFF-based cache) - does not contain these predictions. - - You must either download or create a sqlite database of the predictions. - You may point to the file by adding db=[file] as a parameter: - - --plugin PolyPhen_SIFT,db=[file] - - Human predictions (assembly-independent) are available here: - - https://dl.dropboxusercontent.com/u/12936195/homo_sapiens.PolyPhen_SIFT.db - - (Please note the download location of this file may change) - - Place this file in $HOME/.vep to have the plugin find it automatically. - You may change this directory by adding dir=[dir] as a parameter: - - --plugin PolyPhen_SIFT,dir=[dir] - - To create the database, you must have an active database connection - (i.e. not using --offline) and add create_db=1 as a parameter: - - --plugin PolyPhen_SIFT,create_db=1 - - *** NB: this will take some time!!! *** - - By default the file is created as: - - ${HOME}/.vep/[species].PolyPhen_SIFT.db - -=cut - -package PolyPhen_SIFT; - -use strict; -use warnings; -use DBI; -use Digest::MD5 qw(md5_hex); -use Bio::EnsEMBL::Variation::ProteinFunctionPredictionMatrix; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - my $param_hash = $self->params_to_hash(); - - my $species = $self->config->{species} || 'homo_sapiens'; - my $dir = $param_hash->{dir} || $self->{config}->{dir}; - my $db = $param_hash->{db} || $dir.'/'.$species.'.PolyPhen_SIFT.db'; - - # create DB? - if($param_hash->{create_db}) { - die("ERROR: DB file $db already exists - remove and re-run to overwrite\n") if -e $db; - - $self->{dbh} = DBI->connect("dbi:SQLite:dbname=$db","",""); - $self->{dbh}->do("CREATE TABLE predictions(md5, analysis, matrix)"); - - my $sth = $self->{dbh}->prepare("INSERT INTO predictions VALUES(?, ?, ?)"); - - my $mysql = Bio::EnsEMBL::Registry->get_adaptor($species, 'variation', 'variation')->db->dbc->prepare(qq{ - SELECT m.translation_md5, a.value, p.prediction_matrix - FROM translation_md5 m, attrib a, protein_function_predictions p - WHERE m.translation_md5_id = p.translation_md5_id - AND p.analysis_attrib_id = a.attrib_id - }, {mysql_use_result => 1}); - - my ($md5, $attrib, $matrix); - $mysql->execute(); - $mysql->bind_columns(\$md5, \$attrib, \$matrix); - $sth->execute($md5, $attrib, $matrix) while $mysql->fetch(); - $sth->finish(); - $mysql->finish(); - - $self->{dbh}->do("CREATE INDEX md5_idx ON predictions(md5)"); - } - - die("ERROR: DB file $db not found - you need to download or create it first, see documentation in plugin file\n") unless -e $db; - - $self->{initial_pid} = $$; - $self->{db_file} = $db; - - $self->{dbh} ||= DBI->connect("dbi:SQLite:dbname=$db","",""); - $self->{get_sth} = $self->{dbh}->prepare("SELECT md5, analysis, matrix FROM predictions WHERE md5 = ?"); - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - PolyPhen_humdiv_score => 'PolyPhen humdiv score from PolyPhen_SIFT plugin', - PolyPhen_humdiv_pred => 'PolyPhen humdiv prediction from PolyPhen_SIFT plugin', - PolyPhen_humvar_score => 'PolyPhen humvar score from PolyPhen_SIFT plugin', - PolyPhen_humvar_pred => 'PolyPhen humvar prediction from PolyPhen_SIFT plugin', - SIFT_score => 'SIFT score from PolyPhen_SIFT plugin', - SIFT_pred => 'SIFT prediction from PolyPhen_SIFT plugin', - }; -} - -sub run { - my ($self, $tva) = @_; - - # only for missense variants - return {} unless grep {$_->SO_term eq 'missense_variant'} @{$tva->get_all_OverlapConsequences}; - - my $tr = $tva->transcript; - my $tr_vep_cache = $tr->{_variation_effect_feature_cache} ||= {}; - - ## if predictions are not available for both tools in the cache, look in the SQLite database - unless(exists($tr_vep_cache->{protein_function_predictions}) && - $tva->sift_prediction() && $tva->polyphen_prediction() - ){ - - # get peptide - unless($tr_vep_cache->{peptide}) { - my $translation = $tr->translate; - return {} unless $translation; - $tr_vep_cache->{peptide} = $translation->seq; - } - - # get data, indexed on md5 of peptide sequence - my $md5 = md5_hex($tr_vep_cache->{peptide}); - - my $data = $self->fetch_from_cache($md5); - - unless($data) { - - # forked, reconnect to DB - if($$ != $self->{initial_pid}) { - $self->{dbh} = DBI->connect("dbi:SQLite:dbname=".$self->{db_file},"",""); - $self->{get_sth} = $self->{dbh}->prepare("SELECT md5, analysis, matrix FROM predictions WHERE md5 = ?"); - - # set this so only do once per fork - $self->{initial_pid} = $$; - } - - $self->{get_sth}->execute($md5); - - $data = {}; - - while(my $arrayref = $self->{get_sth}->fetchrow_arrayref) { - my $analysis = $arrayref->[1]; - my ($super_analysis, $sub_analysis) = split('_', $arrayref->[1]); - - $data->{$analysis} = Bio::EnsEMBL::Variation::ProteinFunctionPredictionMatrix->new( - -translation_md5 => $arrayref->[0], - -analysis => $super_analysis, - -sub_analysis => $sub_analysis, - -matrix => $arrayref->[2] - ); - } - - $self->add_to_cache($md5, $data); - } - - $tr_vep_cache->{protein_function_predictions} = $data; - } - - my $return = {}; - - foreach my $tool_string(qw(SIFT PolyPhen_humdiv PolyPhen_humvar)) { - my ($tool, $analysis) = split('_', $tool_string); - my $lc_tool = lc($tool); - - my $pred_meth = $lc_tool.'_prediction'; - my $score_meth = $lc_tool.'_score'; - - my $pred = $tva->$pred_meth($analysis); - - if($pred) { - $pred =~ s/\s+/\_/g; - $pred =~ s/\_\-\_/\_/g; - $return->{$tool_string.'_pred'} = $pred; - - my $score = $tva->$score_meth($analysis); - $return->{$tool_string.'_score'} = $score if defined($score); - } - } - - return $return; -} - -sub fetch_from_cache { - my $self = shift; - my $md5 = shift; - - my $cache = $self->{_cache} ||= []; - - my ($data) = map {$_->{data}} grep {$_->{md5} eq $md5} @$cache; - return $data; -} - -sub add_to_cache { - my $self = shift; - my $md5 = shift; - my $data = shift; - - my $cache = $self->{_cache} ||= []; - push @$cache, {md5 => $md5, data => $data}; - - shift @$cache while scalar @$cache > 50; -} - -1; -
--- a/dir_plugins/ProteinSeqs.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,170 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - ProteinSeqs - -=head1 SYNOPSIS - - mv ProteinSeqs.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin ProteinSeqs,reference.fa,mutated.fa - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - prints out the reference and mutated protein sequences of any - proteins found with non-synonymous mutations in the input file. - - You should supply the name of file where you want to store the - reference protein sequences as the first argument, and a file to - store the mutated sequences as the second argument. - - Note that, for simplicity, where stop codons are gained the plugin - simply substitutes a '*' into the sequence and does not truncate the - protein. Where a stop codon is lost any new amino acids encoded by the - mutation are appended to the sequence, but the plugin does not attempt - to translate until the next downstream stop codon. Also, the protein - sequence resulting from each mutation is printed separately, no attempt - is made to apply multiple mutations to the same protein. - -=cut - -package ProteinSeqs; - -use strict; -use warnings; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '2.4'; -} - -sub feature_types { - return ['Transcript']; -} - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - if($self->{config}->{fork}) { - print STDERR "WARNING: Plugin ProteinSeqs is disabling forking\n" unless $self->{config}->{quiet}; - delete($self->{config}->{fork}); - } - - # use some default file names if none are supplied - - my $ref_file = $self->params->[0] || 'reference.fa'; - my $mut_file = $self->params->[1] || 'mutated.fa'; - - open $self->{ref_file}, ">$ref_file" or die "Failed to open $ref_file"; - open $self->{mut_file}, ">$mut_file" or die "Failed to open $mut_file"; - - return $self; -} - -sub run { - my ($self, $tva) = @_; - - # check if we have a mutant amino acid, if not there isn't much we can do! - - if (my $mut_aa = $tva->peptide) { - - # get the peptide coordinates - - my $tl_start = $tva->transcript_variation->translation_start; - my $tl_end = $tva->transcript_variation->translation_end; - - # and our reference sequence - - my $ref_seq = $tva->transcript_variation->_peptide; - - # splice the mutant peptide sequence into the reference sequence - - my $mut_seq = $ref_seq; - - substr($mut_seq, $tl_start-1, $tl_end - $tl_start + 1) = $mut_aa; - - # print out our reference and mutant sequences - - my $translation_id = $tva->transcript->translation->stable_id; - - # only print the reference sequence if we haven't printed it yet - - $self->print_fasta($ref_seq, $translation_id, $self->{ref_file}) - unless $self->{printed_ref}->{$translation_id}++; - - # we always print the mutated sequence as each mutation may have - # a different consequence - - $self->print_fasta($mut_seq, $tva->hgvs_protein, $self->{mut_file}); - } - - # return an empty hashref because we don't want to add - # anything to the VEP output file - - return {}; -} - -sub print_fasta { - my ($self, $peptide, $id, $fh) = @_; - - # break the sequence into 80 characters per line - - $peptide =~ s/(.{80})/$1\n/g; - - # get rid of any trailing newline - - chomp $peptide; - - # print the sequence - - print $fh ">$id\n$peptide\n"; -} - -sub STORABLE_freeze { - my ($self, $cloning) = @_; - return if $cloning; - - close $self->{ref_file}; - close $self->{mut_file}; - - delete $self->{ref_file}; - delete $self->{ref_file}; -} - -sub STORABLE_thaw { - my ($self, $cloning) = @_; - return if $cloning; - - my $ref_file = $self->params->[0] || 'reference.fa'; - my $mut_file = $self->params->[1] || 'mutated.fa'; - - open $self->{ref_file}, ">>$ref_file" or die "Failed to open $ref_file"; - open $self->{mut_file}, ">>$mut_file" or die "Failed to open $mut_file"; -} - -1;
--- a/dir_plugins/README Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,29 +0,0 @@ -This repository contains several perl plugin modules for the Ensembl -Variant Effect Predictor (VEP). Please refer to the documentation at -the top of each file for details of what each plugin does and how to -run it, though for most you will just need to put the module in your -~/.vep/Plugins directory (or elsewhere on your $PERL5LIB) and then -run the VEP with the argument --plugin <module name>. - -More documentation on VEP plugins, and on the VEP itself, can be -found on the Ensembl website: - -http://www.ensembl.org/info/docs/tools/vep/script/index.html - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -http://www.ensembl.org/info/about/code_licence.html -
--- a/dir_plugins/REVEL.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,125 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - REVEL - -=head1 SYNOPSIS - - mv REVEL.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin REVEL,/path/to/revel/data.tsv.gz - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - adds the REVEL score for missense variants to VEP output. - - Please cite the REVEL publication alongside the VEP if you use this resource: - https://www.ncbi.nlm.nih.gov/pubmed/27666373 - - REVEL scores can be downloaded from: https://sites.google.com/site/revelgenomics/downloads - and can be tabix-processed by: - - cat revel_all_chromosomes.csv | tr "," "\t" > tabbed_revel.tsv - sed '1s/.*/#&/' tabbed_revel.tsv > new_tabbed_revel.tsv - bgzip new_tabbed_revel.tsv - tabix -f -s 1 -b 2 -e 2 new_tabbed_revel.tsv.gz - - The tabix utility must be installed in your path to use this plugin. - -=cut -package REVEL; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - - $self->get_user_params(); - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { REVEL => 'Rare Exome Variant Ensemble Learner '}; -} - -sub run { - my ($self, $tva) = @_; - # only for missense variants - return {} unless grep {$_->SO_term eq 'missense_variant'} @{$tva->get_all_OverlapConsequences}; - - my $vf = $tva->variation_feature; - my $allele = $tva->variation_feature_seq; - my ($res) = grep { - $_->{alt} eq $allele && - $_->{start} eq $vf->{start} && - $_->{end} eq $vf->{end} && - $_->{altaa} eq $tva->peptide - } @{$self->get_data($vf->{chr}, $vf->{start}, $vf->{end})}; - - return $res ? $res->{result} : {}; -} - -sub parse_data { - my ($self, $line) = @_; - - my ($c, $s, $ref, $alt, $refaa, $altaa, $revel_value) = split /\t/, $line; - - return { - alt => $alt, - start => $s, - end => $s, - altaa => $altaa, - result => { - REVEL => $revel_value, - } - }; -} - -sub get_start { - return $_[1]->{start}; -} - -sub get_end { - return $_[1]->{end}; -} - -1;
--- a/dir_plugins/RankFilter.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,119 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - RankFilter - -=head1 SYNOPSIS - - mv RankFilter.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin RankFilter,splice_region_variant - -=head1 DESCRIPTION - - A VEP plugin filter that limits output of predictions to those ranked (by Ensembl) - to be more severe (or at least as severe) as a user specified cutoff. The user can - specify either a numerical rank (lower ranks are assumed to be more severe) or an - SO term to use as the (inclusive) cutoff on the VEP command line. If a term is not - specified the default cutoff term used is 'splice_region_variant' (rank = 8). - - For reference, the table of consequence terms at: - - http://www.ensembl.org/info/docs/variation/index.html#consequence_type_table - - is listed in descending order of severity, so you can refer to this table - to pick your cutoff. - -=cut - -package RankFilter; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::Constants qw(%OVERLAP_CONSEQUENCES); - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepFilterPlugin); - -sub new { - my $class = shift; - - # call the superclass constructor - - my $self = $class->SUPER::new(@_); - - # use splice_region_variant as our default cutoff term - - my $term = $self->params->[0] || 'splice_region_variant'; - - my $rank; - - if ($term =~ /^\d+$/) { - - # we allow the user to specify a numerical rank as - # well as a term - - $rank = $term; - } - elsif (my $oc = $OVERLAP_CONSEQUENCES{$term}) { - - # otherwise we look up the rank from the provided - # SO consequence term - - $rank = $oc->rank; - } - else { - die "Unable to find rank for consequence term: '$term'\n"; - } - - $self->{rank} = $rank; - - return $self; -} - -sub feature_types { - return ['Feature', 'Intergenic']; -} - -sub include_line { - my ($self, $tva) = @_; - - # check all the consequences in turn - - for my $oc (@{ $tva->get_all_OverlapConsequences }) { - - # and include this line if the rank of any of the - # consequences for this TVA is less than our cutoff - # (lower rank is assumed to be more deleterious) - - if ($oc->rank <= $self->{rank}) { - return 1; - } - } - - return 0; -} - -1; -
--- a/dir_plugins/RefSeqHGVS.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,208 +0,0 @@ -=head1 NAME - - RefSeqHGVS -- provide RefSeq-based HGVS tags for VEP output - -=head1 SYNOPSIS - - cp RefSeqHGVS.pm ~/.vep/Plugins/ (or elsewhere in PERL5LIB) - perl variant_effect_predictor.pl -i variations.vcf --plugin RefSeqHGVS - - Output: - Variant lines with the following addtiional tags: - HGVSc-RefSeq=NM_198156.2:c.403delA;HGVSp-RefSeq=NP_937799.1:p.Arg135GlyfsX26 - -=head1 DESCRIPTION - - RefSeqHGVS is a plugin for Ensembl's Variant Effect Predictor that - provides variant annotatoins in HGVS format [1] using RefSeq accessions - (typically NM and NP). It provides the analog to VEP's HGVSc and HGVSp - annotations, which use Ensembl ENST and ENSP accessions. This module - relies RefSeq data in the OtherFeatures database. - - Converting ENST HGVS tags to RefSeq tags is confounded subtle differences - between exon structures for the same CDS. The plugin is intended to be - conservative by requiring exact matches of both CDS and exon structure - when converting variants. - - [1] http://www.hgvs.org/mutnomen/ - -=head1 BUGS AND LIMITATIONS - -=over - -=item * RefSeq transcripts limited to those in the OtherFeatures database. - -Archived RefSeq transcripts are not available. - -=item * Discrepancies between RefSeq and GRCh37 - - Approximately 20% of RefSeqs differ from the GRCh37 due to substitution - (16.2%), insertion/deletion (3.5%), or both (1.2%) differences. [1] - Variants are annotated by difference with respect to the genome, not the - RefSeq transcript. - - [1] MU2A--reconciling the genome and transcriptome to determine the - effects of base substitutions. -Garla, V., Kong, Y., Szpakowski, S., & Krauthammer, M. (2011). - Bioinformatics, 27(3), 416-8. doi:10.1093/bioinformatics/btq658 - http://www.ncbi.nlm.nih.gov/pubmed/21149339 - -=item * Conservative selection of equivalent RefSeq transcripts. - -Only NM transcripts which are exactly identical to the ENST transcript in -both CDS and exon structure are used. In the future, this might be -relaxed to exclude only regions of mismatch. Currently, this implies that -HGVS tags are not constructued when the RefSeq differs from the reference -geneome. - -=back - -=head1 CONTACT - - Reece Hart <reecehart@gmail.com> - -=head1 LICENSE - - This code and all rights to it are hereby donated to EnsEMBL project by - Reece Hart and Locus Development. - - Copyright (c) 1999-2011 The European Bioinformatics Institute and - Genome Research Limited. All rights reserved. - - This software is distributed under a modified Apache license. - For license details, please see - - http://www.ensembl.org/info/about/code_licence.html - -=cut - - -package RefSeqHGVS; - -use strict; -use warnings; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -use Data::Dumper; - -my %mt_cache; # cache of ENST -> NM mappings - -sub version { - return '2.3'; -} - -sub new { - my $class = shift; - my $self = $class->SUPER::new(@_); - my $reg = 'Bio::EnsEMBL::Registry'; - - $self->{ofsa} = $reg->get_adaptor('Human', 'otherfeatures', 'Slice') - or die "Failed to create transcript adaptor in human otherfeatures database\n"; - $self->{ofta} = $reg->get_adaptor('Human', 'otherfeatures', 'Transcript') - or die "Failed to create transcript adaptor in human otherfeatures database\n"; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['VariationFeature']; -} - -sub get_header_info { - return { - 'HGVSc-RefSeq' => "HGVSc using RefSeq transcripts accessions", - 'HGVSp-RefSeq' => "HGVSp using RefSeq protein accessions", - }; -} - -sub run { - my ($self, $tva) = @_; - my $t = $tva->transcript; - my %rv; - - my $ofsa = $self->{ofsa}; - my $ofta = $self->{ofta}; - - # mappabale_transcripts have identical CDS and exon structure - my @mappable_transcripts = $self->get_mappable_transcripts($t); - my @transcript_acs = map { $_->display_id() } @mappable_transcripts; - my @protein_acs = grep {defined $_} map { $_->translation()->display_id() } @mappable_transcripts; - - # substitute accessions for those in mappable transcripts/proteins - my @hgvsc_rs; - if (defined (my $hgvsc = $tva->hgvs_coding())) { - @hgvsc_rs = map {__subst_hgvs_ac($hgvsc ,$_)} @transcript_acs; - } - my @hgvsp_rs; - if (defined (my $hgvsp = $tva->hgvs_protein())) { - @hgvsp_rs = map {__subst_hgvs_ac($hgvsp,$_)} @protein_acs; - } - - $rv{'HGVSc-RefSeq'} = join(';',@hgvsc_rs) if @hgvsc_rs; - $rv{'HGVSp-RefSeq'} = join(';',@hgvsp_rs) if @hgvsp_rs; - return \%rv; -} - - -sub get_mappable_transcripts { - my ($self,$t) = @_; - my $key = $t->display_id(); - if (not exists $mt_cache{$key}) { - @{$mt_cache{$key}} = $self->_get_mappable_transcripts($t); - } - return @{$mt_cache{$key}}; -} - - -############################################################################ -## internal methods -sub _get_mappable_transcripts { - my ($self,$t) = @_; - my $cds_seq = $t->translateable_seq(); - my $exon_structure = __tx_exon_str($t); - - # cds_seq is empty for pseudogenes; no mapping possible - return () if ($cds_seq eq ''); - - # get overlapping transcripts from other features - my @tx = @{ $self->{ofta}->fetch_all_by_Slice($t->feature_Slice()) }; - - # limit to NMs with standard-format - @tx = grep { $_->display_id() =~ m/^NM_\d+\.\d+$/ } @tx; - - # limit to transcripts with same CDS - @tx = grep { $_->translateable_seq() eq $cds_seq } @tx; - - # limit to transcripts with identical chromosomal exon structure - @tx = grep { __tx_exon_str($_->transform('chromosome')) eq $exon_structure } @tx; - - return @tx; -} - - -############################################################################ -## function (not methods) - -sub __tx_exon_str { - my $t = shift; - return join(',', map {sprintf('[%s,%s]', $_->start(), $_->end())} - @{ $t->get_all_translateable_Exons() } ); -} - -sub __subst_hgvs_ac { - my ($hgvs,$ac) = @_; - $hgvs =~ s/^[^:]+:/$ac:/; - return $hgvs; -} - -sub __uniq { - return keys %{{ map {$_=>1} @_ }}; -} - - -1;
--- a/dir_plugins/SameCodon.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,117 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - SameCodon - -=head1 SYNOPSIS - - mv SameCodon.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin SameCodon - -=head1 DESCRIPTION - - A VEP plugin that reports existing variants that fall in the same codon. - -=cut - -package SameCodon; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '3.0'; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - SameCodon => "Existing variant IDs that fall in the same codon", - }; -} - -sub run { - - my ($self, $tva) = @_; - - if ($self->config->{offline}) { - die "A connection to the database is required to use the plugin SameCodon\n"; - } - - my $tv = $tva->transcript_variation; - my $vf = $tv->variation_feature; - my ($pep_start, $pep_end) = ($tv->translation_start, $tv->translation_end); - my ($vf_start, $vf_end) = ($vf->start, $vf->end); - - return {} unless defined($pep_start) && defined($pep_end); - - my $config = $self->{config}; - - # we need to map the TV start and end coords to the genome - # needs to be done through the mapper in case the codon spans exons - my $mapper = $tv->_mapper(); - - return {} unless defined($mapper); - - my @coords = $mapper->pep2genomic($pep_start, $pep_end); - - return {} unless scalar @coords; - return {} if grep {!$_->isa('Bio::EnsEMBL::Mapper::Coordinate')} @coords; - - my @results; - # we might get multiple "slices" if the codon that the variant falls in spans exons - foreach my $coord(@coords) { - - my ($slice_start, $slice_end) = ($coord->start, $coord->end); - - my $sub_slice = $vf->slice->sub_Slice($slice_start, $slice_end); - my $vf_adaptor = $vf->slice->_get_VariationFeatureAdaptor(); - push @results, - map {$_->variation_name} - grep { - $_->variation_name ne $vf->variation_name && - $_->seq_region_start != $vf_start && - $_->seq_region_end != $vf_end && - scalar $mapper->genomic2cds($_->seq_region_start, $_->seq_region_end, 1) >= 1 - } - @{$vf_adaptor->fetch_all_by_Slice_SO_terms($sub_slice)}; - } - - return {} unless scalar @results; - - return { - SameCodon => join ",", @results - } -} - -1; -
--- a/dir_plugins/SpliceRegion.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,184 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <dev@ensembl.org> - -=cut - -=head1 NAME - - SpliceRegion - -=head1 SYNOPSIS - - mv SpliceRegion.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin SpliceRegion - - To only show the additional consequence extended_intronic_splice_region_variant, use: - ./vep -i variations.vcf --plugin SpliceRegion,Extended - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - provides more granular predictions of splicing effects. - - Three additional terms may be added: - - # splice_donor_5th_base_variant : variant falls in the 5th base after the splice donor junction (5' end of intron) - - v - ...EEEEEIIIIIIIIII... - - (E = exon, I = intron, v = variant location) - - # splice_donor_region_variant : variant falls in region between 3rd and 6th base after splice junction (5' end of intron) - - vv vvv - ...EEEEEIIIIIIIIII... - - # splice_polypyrimidine_tract_variant : variant falls in polypyrimidine tract at 3' end of intron, between 17 and 3 bases from the end - - vvvvvvvvvvvvvvv - ...IIIIIIIIIIIIIIIIIIIIEEEEE... - - -=cut - -package SpliceRegion; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::VariationEffect qw(overlap); -use Bio::EnsEMBL::Variation::Utils::Constants qw(%OVERLAP_CONSEQUENCES); - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -my %TERM_RANK = ( - splice_donor_5th_base_variant => 1, - splice_donor_region_variant => 2, - splice_polypyrimidine_tract_variant => 3, - extended_intronic_splice_region_variant_5prime => 4, - extended_intronic_splice_region_variant_3prime => 5, -); - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - SpliceRegion => "SpliceRegion predictions", - }; -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - my ($vf_start, $vf_end) = ($vf->{start}, $vf->{end}); - - my $is_insertion = 0; - if($vf_start > $vf_end) { - ($vf_start, $vf_end) = ($vf_end, $vf_start); - $is_insertion = 1; - } - - my $tv = $tva->transcript_variation; - my $tr = $tv->transcript; - my $vf_tr_seq = $tva->feature_seq; - - # define some variables depending on transcript strand - my ($strand_mod, $donor_coord, $acc_coord); - if($tr->strand > 0) { - $strand_mod = 1; - $donor_coord = 'start'; - $acc_coord = 'end'; - } - else { - $strand_mod = -1; - $donor_coord = 'end'; - $acc_coord = 'start'; - } - - my %results; - - my @terms; - my $extended_flag = lc($self->params->[0] || "") eq 'extended'; - for my $intron(@{$tv->_overlapped_introns($vf_start, $vf_end)}) { - - # define terms to check for and their regions - @terms = ( - { - term => 'splice_donor_5th_base_variant', - region => [$intron->{$donor_coord} + (4 * $strand_mod), $intron->{$donor_coord} + (4 * $strand_mod)] - }, - { - term => 'splice_donor_region_variant', - region => [$intron->{$donor_coord} + (2 * $strand_mod), $intron->{$donor_coord} + (5 * $strand_mod)] - }, - { - term => 'splice_polypyrimidine_tract_variant', - region => [$intron->{$acc_coord} + (-16 * $strand_mod), $intron->{$acc_coord} + (-2 * $strand_mod)], - # allele_specific_mod => { - # A => '_to_purine', - # G => '_to_purine', - # } - }, - ) unless $extended_flag; - - @terms = ( - { - term => 'extended_intronic_splice_region_variant_5prime', - region => [$intron->{$donor_coord}, $intron->{$donor_coord} + (9 * $strand_mod)] - }, - { - term => 'extended_intronic_splice_region_variant_3prime', - region => [$intron->{$acc_coord} + (-9 * $strand_mod), $intron->{$acc_coord} ], - # allele_specific_mod => { - # A => '_to_purine', - # G => '_to_purine', - # } - }, - ) if $extended_flag; - - - foreach my $term_hash(@terms) { - my $pass = overlap($vf_start, $vf_end, sort {$a <=> $b} @{$term_hash->{region}}); - if($pass) { - my $term = $term_hash->{term}; - $term = 'extended_intronic_splice_region_variant' if $extended_flag; - - # if(my $allele_specific_mods = $term_hash->{allele_specific_mod}) { - # $term .= $allele_specific_mods->{$vf_tr_seq} || ''; - # } - - $results{$term}++; - last; - } - } - } - - return {} unless %results; - - return { SpliceRegion => [sort {$TERM_RANK{$a} <=> $TERM_RANK{$b}} keys %results]}; -} - -1; -
--- a/dir_plugins/SubsetVCF.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,226 +0,0 @@ -=head1 NAME - - SubsetVCF - -=head1 DESCRIPTION - - A VEP plugin to retrieve overlapping records from a given VCF file. - Values for POS, ID, and ALT, are retrieved as well as values for any requested - INFO field. Additionally, the allele number of the matching ALT is returned. - - Though similar to using '--custom', this plugin returns all ALTs for a given - POS, as well as all associated INFO values. - - By default, only VCF records with a filter value of "PASS" are returned, - however this behaviour can be changed via the 'filter' option. - - Parameters: - name: short name added used as a prefix (required) - file: path to tabix-index vcf file (required) - filter: only consider variants marked as 'PASS', 1 or 0 (default, 1) - fields: info fields to be returned (default, not used) - '%' can delimit multiple fields - '*' can be used as a wildcard - - Returns: - <name>_POS: POS field from VCF - <name>_REF: REF field from VCF (minimised) - <name>_ALT: ALT field from VCF (minimised) - <name>_alt_index: Index of matching variant (zero-based) - <name>_<field>: List of requested info values - -=head1 SYNOPSIS - - ./vep -i variations.vcf --plugin SubsetVCF,file=filepath.vcf.gz,name=myvfc,fields=AC*%AN* - -=head1 CONTACT - - Joseph A. Prinz <jp102@duke.edu> - -=head1 LICENSE - - Licensed under the Apache License, Version 2.0 (the "License"); - you may not use this file except in compliance with the License. - You may obtain a copy of the License at - http://www.apache.org/licenses/LICENSE-2.0 - Unless required by applicable law or agreed to in writing, software - distributed under the License is distributed on an "AS IS" BASIS, - WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. - See the License for the specific language governing permissions and - limitations under the License. - -=cut - -package SubsetVCF; - -use strict; -use warnings; - -use Storable qw(dclone); -use Data::Dumper; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); -use Bio::EnsEMBL::Variation::Utils::Sequence qw(get_matched_variant_alleles); -use Bio::EnsEMBL::Variation::Utils::VEP qw(parse_line get_all_consequences); -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -sub simple_vf { - my ($vf, $params) = @_; - my @alleles = split /\//, $vf->{allele_string}; - my $ref = shift @alleles; - - my @line; - if (ref $vf->{_line} ne "ARRAY") { - @line = split /\t/, $vf->{_line}; - } else { - @line = @{$vf->{_line}}; - } - - # Use a particular allele if requested - @alleles = ($params->{allele}) if $params->{allele}; - - # Reverse comp if needed - if ($vf->{strand} < 0) { - @alleles = map { reverse_comp($_) } @alleles; - $ref = reverse_comp($ref); - $vf->{strand} = 1; - } - - # Return values - my $ret = { - chr => $vf->{chr}, - pos => $vf->{start}, - start => $vf->{start}, - end => $vf->{end}, - strand => $vf->{strand}, - alts => [@alleles], - line => [@line], - ref => $ref}; - - # If filter is true, only return $ret if filter eq "PASS" - return $params->{filter} && $line[6] ne "PASS" ? {} : $ret; -} - -sub parse_info { - my ($line, $valid_fields) = @_; - my %ret; - for my $dat (split /;/, $line->[7]) { - my ($field, $val) = split /=/, $dat; - if (grep { $field eq $_ } @$valid_fields) { - $ret{$field} = [split /,/, $val]; - } - } - return \%ret; -} - -sub new { - my $class = shift; - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - $self->get_user_params(); - - # Get params and ensure a minumum number of parameters - my $params = $self->params_to_hash(); - die "ERROR: no value for 'file' specified" if !$params->{file}; - die "ERROR: no value for 'name' specified" if !$params->{name}; - - # Defaults - $params->{filter} = 1 if !$params->{filter}; - - # Add file via parameter hash - $self->add_file($params->{file}); - $self->{filter} = $params->{filter}; - $self->{name} = $params->{name}; - - if ($params->{fields}) { - # Mung filter to turn AC*%AN* into AC[^,]+|AN[^,]+ - $params->{fields} =~ s/%/|/g; - $params->{fields} =~ s/\*/[^,]*/g; - - # Get input file headers - my %fields; - my $info_regex = "^##INFO=<ID=($params->{fields}),.*Description=\"([^\"]+).*"; - open HEAD, "tabix -fh $params->{file} 1:1-1 2>&1 | "; - while(my $line = <HEAD>) { - next unless $line =~ $info_regex; - $fields{$1} = $2; - } - die "Could not find any valid info fields" if not %fields; - $self->{fields} = \%fields; - $self->{valid_fields} = [keys %fields]; - } - return $self; -} - -sub feature_types { - return ['Feature', 'Intergenic']; -} - -sub get_header_info { - my $self = shift; - my %ret; - - # Add fields if requested - if ($self->{fields}) { - while (my ($field, $desc) = each %{$self->{fields}}) { - $ret{"$self->{name}_$field"} = $desc; - } - } - - $ret{"$self->{name}_ID"} = "Original ID"; - $ret{"$self->{name}_POS"} = "Original POS"; - $ret{"$self->{name}_REF"} = "Original refrance allele"; - $ret{"$self->{name}_ALT"} = "Original alternatives as they appear in the VCF file"; - $ret{"$self->{name}_alt_index"} = "Index of matching alternative (zero-based)"; - return \%ret; -} - -sub parse_data { - my ($self, $line) = @_; - my ($vf) = @{parse_line({format => 'vcf', minimal => 1}, $line)}; - return simple_vf($vf, {filter => $self->{filter}}); -} - -sub run { - my ($self, $tva) = @_; - my $vf = simple_vf($tva->variation_feature, {allele => $tva->{variation_feature_seq}}); - - # Zero-indexing start for tabix and adding 1 to end for VEP indels - my @data = @{$self->get_data($vf->{chr}, ($vf->{start} - 1), ($vf->{end} + 1))}; - - my (%ret, $found_vf, @matches); - for my $dat (@data) { - next unless %$dat; - @matches = @{get_matched_variant_alleles($vf, $dat)}; - if (@matches) { - $found_vf = dclone $dat; - last; - } - } - - if (@matches) { - # Return the index of matching found alleles - my @found_alts = map { $_->{b_index} } @matches; - - # Parse info fields if needed - if ($self->{fields}) { - my %found_fields = %{parse_info($found_vf->{line}, $self->{valid_fields})}; - while (my ($field, $val) = each %found_fields) { - $ret{"$self->{name}_$field"} = [@$val]; - } - } - - $ret{"$self->{name}_ID"} = $found_vf->{line}->[2]; - $ret{"$self->{name}_POS"} = $found_vf->{pos}; - $ret{"$self->{name}_POS"} = $found_vf->{pos}; - $ret{"$self->{name}_REF"} = $found_vf->{ref}; - $ret{"$self->{name}_ALT"} = $found_vf->{alts}; - $ret{"$self->{name}_alt_index"} = [@found_alts]; - } - return \%ret; -} - -1;
--- a/dir_plugins/TSSDistance.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,85 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - TSSDistance - -=head1 SYNOPSIS - - mv TSSDistance.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin CCDSFilter - -=head1 DESCRIPTION - - A VEP plugin that calculates the distance from the transcription - start site for upstream variants. - -=cut - -package TSSDistance; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub get_header_info { - return { - TSSDistance => "Distance from the transcription start site" - }; -} - -sub feature_types { - return ['Transcript']; -} - -sub variant_feature_types { - return ['BaseVariationFeature']; -} - -sub run { - my ($self, $tva) = @_; - - my $t = $tva->transcript; - my $vf = $tva->base_variation_feature; - - my $dist; - - if ($t->strand == 1) { - $dist = $t->start - $vf->end; - } - else { - $dist = $vf->start - $t->end; - } - - if ($dist > 0) { - return { - TSSDistance => $dist, - } - } - else { - return {}; - } -} - -1;
--- a/dir_plugins/Wildtype.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,72 +0,0 @@ -=head1 NAME - - Wildtype - -=head1 SYNOPSIS - - mv Wildtype.pm ~/.vep/Plugins - perl variant_effect_predictor.pl -i variations.vcf --plugin Wildtype - -=head1 DESCRIPTION - - This is a plugin for the Ensembl Variant Effect Predictor (VEP) that - provides the wildtype protein sequence of a transcript. - -=cut - -package Wildtype; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub version { - return '1.0'; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - return { - WildtypeProtein => "The normal, non-mutated protein sequence", - }; -} - -sub run { - my ($self, $tva) = @_; - - my $tv = $tva->transcript_variation; - my $tr = $tv->transcript; - my $cds_seq = defined($tr->{_variation_effect_feature_cache}) ? $tr->{_variation_effect_feature_cache}->{translateable_seq} : $tr->translateable_seq; - my $codon_seq = Bio::Seq->new( - -seq => $cds_seq, - -moltype => 'dna', - -alphabet => 'dna' - ); - - #get codon table - my $codon_table; - if(defined($tr->{_variation_effect_feature_cache})) { - $codon_table = $tr->{_variation_effect_feature_cache}->{codon_table} || 1; - } - else { - my ($attrib) = @{$tr->slice->get_all_Attributes('codon_table')}; - $codon_table = $attrib ? $attrib->value || 1 : 1; - } - - # translate - my $new_pep = $codon_seq->translate(undef, undef, undef, $codon_table)->seq(); - $new_pep =~ s/\*.*//; - - return { - WildtypeProtein => $new_pep, - }; -} - -1; -
--- a/dir_plugins/config/Condel/config/condel_SP.conf Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,11 +0,0 @@ -condel.dir='path/to/config/Condel/' - -#------------------------------------------------------------------------------ -cutoff.HumVar.sift='0.15' -cutoff.HumVar.polyphen='0.28' -cutoff.HUmVar.condel='0.46' -#------------------------------------------------------------------------------ -max.HumVar.sift='1' -max.HumVar.polyphen='1' - -
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--- a/dir_plugins/config/Condel/methdist/test_condel_SP.data Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,35 +0,0 @@ -ENSP00000415759_D504G 0.63 0.0020 -ENSP00000415759_G15A 0.99 0.9550 -ENSP00000415759_G8R 0 0.9880 -ENSP00000415759_G90D 0.65 0.0000 -ENSP00000415759_K343E 0.21 0.0000 -ENSP00000415759_L101P 0 0.9980 -ENSP00000415759_L499I 0.26 0.0030 -ENSP00000358424_L166V 0.01 0.7650 -ENSP00000358424_K244P 0.01 0.2660 -ENSP00000358424_G9E 0 0.9990 -ENSP00000409746_G420E 0 0.9950 -ENSP00000409746_G420R 0 0.9950 -ENSP00000409746_P418H 0 0.9990 -ENSP00000242210_Y98V 0.5 0.0030 -ENSP00000242210_G241R 0.02 0.9940 -ENSP00000242210_V142P 0.01 0.0000 -ENSP00000242210_D190S 0.14 0.0010 -ENSP00000371493_V411M 0.03 0.1790 -ENSP00000284981_E693G 0 0.8990 -ENSP00000284981_E693K 0.01 0.7970 -ENSP00000209873_H160R 0.08 0.9990 -ENSP00000209873_Q15K 0 0.0060 -ENSP00000209873_S263P 0.02 0.9770 -ENSP00000376795_L78P 0.01 1.0000 -ENSP00000376795_P252A 1 0.0340 -ENSP00000287878_H383R 0.29 0.5990 -ENSP00000287878_N488I 0.12 0.1490 -ENSP00000406366_R180L 0.72 0.0020 -ENSP00000396220_R180L 0.72 0.0020 -ENSP00000404678_R41S 0.32 0.0030 -ENSP00000403575_A260E 0.03 0.9780 -ENSP00000403575_A65G 0.04 0.0040 -ENSP00000403575_D54N 0.05 0.0050 -ENSP00000399020_M162K 0.19 0.6630 -variant1_1263085_G/A 0.13 0.1
--- a/dir_plugins/dbNSFP.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,383 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - dbNSFP - -=head1 SYNOPSIS - - mv dbNSFP.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin dbNSFP,/path/to/dbNSFP.gz,col1,col2 - -=head1 DESCRIPTION - - A VEP plugin that retrieves data for missense variants from a tabix-indexed - dbNSFP file. - - Please cite the dbNSFP publication alongside the VEP if you use this resource: - http://www.ncbi.nlm.nih.gov/pubmed/21520341 - - You must have the Bio::DB::HTS module or the tabix utility must be installed - in your path to use this plugin. The dbNSFP data file can be downloaded from - https://sites.google.com/site/jpopgen/dbNSFP. - - Release 3.5a of dbNSFP uses GRCh38/hg38 coordinates and GRCh37/hg19 - coordinates. - To use plugin with GRCh37/hg19 data: - > wget ftp://dbnsfp:dbnsfp@dbnsfp.softgenetics.com/dbNSFPv3.5a.zip - > unzip dbNSFPv3.5a.zip - > head -n1 dbNSFP3.5a_variant.chr1 > h - > cat dbNSFP3.5a_variant.chr* | grep -v ^#chr | awk '$8 != "."' | sort -k8,8 -k9,9n - | cat h - | bgzip -c > dbNSFP_hg19.gz - > tabix -s 8 -b 9 -e 9 dbNSFP_hg19.gz - - To use plugin with GRCh38/hg38 data: - > wget ftp://dbnsfp:dbnsfp@dbnsfp.softgenetics.com/dbNSFPv3.5a.zip - > unzip dbNSFPv3.5a.zip - > head -n1 dbNSFP3.5a_variant.chr1 > h - > cat dbNSFP3.5a_variant.chr* | grep -v ^#chr | sort -k1,1 -k2,2n - | cat h - | bgzip -c > dbNSFP.gz - > tabix -s 1 -b 2 -e 2 dbNSFP.gz - - When running the plugin you must list at least one column to retrieve from the - dbNSFP file, specified as parameters to the plugin e.g. - - --plugin dbNSFP,/path/to/dbNSFP.gz,LRT_score,GERP++_RS - - You may include all columns with ALL; this fetches a large amount of data per - variant!: - - --plugin dbNSFP,/path/to/dbNSFP.gz,ALL - - Tabix also allows the data file to be hosted on a remote server. This plugin is - fully compatible with such a setup - simply use the URL of the remote file: - - --plugin dbNSFP,http://my.files.com/dbNSFP.gz,col1,col2 - - The plugin replaces occurrences of ';' with ',' and '|' with '&'. However, some - data field columns, e.g. Interpro_domain, use the replacement characters. We - added a file with replacement logic for customising the required replacement - of ';' and '|' in dbNSFP data columns. In addition to the default replacements - (; to , and | to &) users can add customised replacements. Users can either modify - the file dbNSFP_replacement_logic in the VEP_plugins directory or provide their own - file as second argument when calling the plugin: - - --plugin dbNSFP,/path/to/dbNSFP.gz,/path/to/dbNSFP_replacement_logic,LRT_score,GERP++_RS - - Note that transcript sequences referred to in dbNSFP may be out of sync with - those in the latest release of Ensembl; this may lead to discrepancies with - scores retrieved from other sources. - - If the dbNSFP README file is found in the same directory as the data file, - column descriptions will be read from this and incorporated into the VEP output - file header. - -=cut - -package dbNSFP; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -my %INCLUDE_SO = map {$_ => 1} qw(missense_variant stop_lost stop_gained start_lost); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - - # get dbNSFP file - my $file = $self->params->[0]; - $self->add_file($file); - - # get headers - open HEAD, "tabix -fh $file 1:1-1 2>&1 | "; - while(<HEAD>) { - next unless /^\#/; - chomp; - $self->{headers} = [split]; - } - close HEAD; - - die "ERROR: Could not read headers from $file\n" unless defined($self->{headers}) && scalar @{$self->{headers}}; - - # check alt and Ensembl_transcriptid headers - foreach my $h(qw(alt Ensembl_transcriptid)) { - die "ERROR: Could not find required column $h in $file\n" unless grep {$_ eq $h} @{$self->{headers}}; - } - - my $i = 1; - # check if 2nd argument is a file that specifies replacement logic - # read replacement logic - my $replacement_file = $self->params->[$i]; - if (defined $replacement_file && -e $replacement_file) { - $self->add_replacement_logic($replacement_file); - $i++; - } else { - $self->add_replacement_logic(); - } - - # get required columns - while(defined($self->params->[$i])) { - my $col = $self->params->[$i]; - if($col eq 'ALL') { - $self->{cols} = {map {$_ => 1} @{$self->{headers}}}; - last; - } - die "ERROR: Column $col not found in header for file $file. Available columns are:\n".join(",", @{$self->{headers}})."\n" unless grep {$_ eq $col} @{$self->{headers}}; - - $self->{cols}->{$self->params->[$i]} = 1; - $i++; - } - - die "ERROR: No columns selected to fetch. Available columns are:\n".join(",", @{$self->{headers}})."\n" unless defined($self->{cols}) && scalar keys %{$self->{cols}}; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - my $self = shift; - - if(!exists($self->{_header_info})) { - - # look for readme - my $file_dir = $self->files->[0]; - - my %rm_descs; - - # won't work for remote - if($file_dir !~ /tp\:\/\//) { - - # get just dir - $file_dir =~ s/\/[^\/]+$/\//; - - if(opendir DIR, $file_dir) { - my ($readme_file) = grep {/dbnsfp.*readme\.txt/i} readdir DIR; - closedir DIR; - - if(open RM, $file_dir.$readme_file) { - my ($col, $reading); - - # parse dbNSFP readme - # relevant lines look like: - # - # 1 column1_name: description blah blah - # blah blah blah - # 2 column2_name: description blah blah - # blah blah blah - - while(<RM>) { - chomp; - s/\r$//g; - - if(/^\d+\s/) { - $reading = 1; - - m/^\d+\s+(.+?)\:\s+(.+)/; - $col = $1; - - $rm_descs{$col} = '(from dbNSFP) '.$2 if $col && $2; - } - elsif($reading && /\w/) { - s/^\s+//; - $rm_descs{$col} .= ' '.$_; - } - else { - $reading = 0; - } - } - - close RM; - - # remove multiple spaces - $rm_descs{$_} =~ s/\s+/ /g for keys %rm_descs; - } - } - } - - $self->{_header_info} = {map {$_ => $rm_descs{$_} || ($_.' from dbNSFP file')} keys %{$self->{cols}}}; - } - - return $self->{_header_info}; -} - -sub run { - my ($self, $tva) = @_; - - # only for missense variants - return {} unless grep {$INCLUDE_SO{$_->SO_term}} @{$tva->get_all_OverlapConsequences}; - - my $vf = $tva->variation_feature; - - return {} unless $vf->{start} eq $vf->{end}; - - # get allele, reverse comp if needed - my $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - return {} unless $allele =~ /^[ACGT]$/; - - # get transcript stable ID - my $tr_id = $tva->transcript->stable_id; - - my $data; - my $pos; - - my $assembly = $self->{config}->{assembly}; - my $chr = ($vf->{chr} =~ /MT/i) ? 'M' : $vf->{chr}; - foreach my $tmp_data(@{$self->get_data($chr, $vf->{start} - 1, $vf->{end})}) { - # compare allele and transcript - if ($assembly eq 'GRCh37') { - if (exists $tmp_data->{'pos(1-coor)'}) { - # for dbNSFP version 2.9.1 - $pos = $tmp_data->{'pos(1-coor)'} - } elsif (exists $tmp_data->{'hg19_pos(1-based)'}) { - # for dbNSFP version 3.5c indexed for hg19/(=GRCh37) - $pos = $tmp_data->{'hg19_pos(1-based)'} - } else { - die "dbNSFP file does not contain required columns (pos(1-coor) for version 2.9.1 or hg19_pos(1-based) for version 3.5c) to use with GRCh37"; - } - } else { - if (exists $tmp_data->{'pos(1-based)'}) { - $pos = $tmp_data->{'pos(1-based)'} - } else { - die "dbNSFP file does not contain required column pos(1-based) to use with GRCh38"; - } - } - - next unless - $pos == $vf->{start} && - defined($tmp_data->{alt}) && - $tmp_data->{alt} eq $allele; - - # make a clean copy as we're going to edit it - %$data = %$tmp_data; - - # convert data with multiple transcript values - # if($data->{Ensembl_transcriptid} =~ m/\;/) { - - # # find the "index" of this transcript - # my @tr_ids = split(';', $data->{Ensembl_transcriptid}); - # my $tr_index; - - # for my $i(0..$#tr_ids) { - # $tr_index = $i; - # last if $tr_ids[$tr_index] =~ /^$tr_id(\.\d+)?$/; - # } - - # next unless defined($tr_index); - - # # now alter other fields - # foreach my $key(keys %$data) { - # if($data->{$key} =~ m/\;/) { - # my @split = split(';', $data->{$key}); - # die("ERROR: Transcript index out of range") if $tr_index > $#split; - # $data->{$key} = $split[$tr_index]; - # } - # } - # } - last; - } - - return {} unless scalar keys %$data; - - # get required data - my @from = @{$self->{replacement}->{default}->{from}}; - my @to = @{$self->{replacement}->{default}->{to}}; - - my %return; - foreach my $colname (keys %$data) { - next if(!defined($self->{cols}->{$colname})); - next if($data->{$colname} eq '.'); - - my @from = @{$self->{replacement}->{default}->{from}}; - my @to = @{$self->{replacement}->{default}->{to}}; - @from = @{$self->{replacement}->{$colname}->{from}} if (defined $self->{replacement}->{$colname}); - @to = @{$self->{replacement}->{$colname}->{to}} if (defined $self->{replacement}->{$colname}); - for my $i (0 .. $#from) { - $data->{$colname} =~ s/\Q$from[$i]\E/$to[$i]/g; - } - $return{$colname} = $data->{$colname}; - } - - return \%return; -} - -sub parse_data { - my ($self, $line) = @_; - - $line =~ s/\r$//g; - - my @split = split /\t/, $line; - - # parse data into hash of col names and values - my %data = map {$self->{headers}->[$_] => $split[$_]} (0..(scalar @{$self->{headers}} - 1)); - - return \%data; -} - -sub get_start { - return $_[1]->{'pos(1-based)'}; -} - -sub get_end { - return $_[1]->{'pos(1-based)'}; -} - -sub add_replacement_logic { - my $self = shift; - my $file = shift; - $file ||= 'dbNSFP_replacement_logic'; - if (! -e $file) { - $self->{replacement}->{default}->{from} = [';', '|']; - $self->{replacement}->{default}->{to} = [',', '&']; - } else { - open FILE, $file; - while(<FILE>) { - chomp; - next if /^colname/; - my ($colname, $from, $to) = split/\s+/; - die ("ERROR: 3 values separated by whitespace are required: colname from to.") if(!($colname && $from && $to)); - push @{$self->{replacement}->{$colname}->{from}}, $from; - push @{$self->{replacement}->{$colname}->{to}}, $to; - } - close FILE; - die("ERROR: No default replacement logic has been specified.\n") if (!defined $self->{replacement}->{default}); - } -} - -1; - -
--- a/dir_plugins/dbNSFP_replacement_logic Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,5 +0,0 @@ -colname from to -default ; , -default | & -Interpro_domain ; ? -Interpro_domain | +
--- a/dir_plugins/dbscSNV.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,234 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - dbscSNV - -=head1 SYNOPSIS - - mv dbscSNV.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin dbscSNV,/path/to/dbscSNV1.1_GRCh38.txt.gz - -=head1 DESCRIPTION - - A VEP plugin that retrieves data for splicing variants from a tabix-indexed - dbscSNV file. - - Please cite the dbscSNV publication alongside the VEP if you use this resource: - http://nar.oxfordjournals.org/content/42/22/13534 - - The Bio::DB::HTS perl library or tabix utility must be installed in your path - to use this plugin. The dbscSNV data file can be downloaded from - https://sites.google.com/site/jpopgen/dbNSFP. - - The file must be processed and indexed by tabix before use by this plugin. - dbscSNV1.1 has coordinates for both GRCh38 and GRCh37; the file must be - processed differently according to the assembly you use. - - > wget ftp://dbnsfp:dbnsfp@dbnsfp.softgenetics.com/dbscSNV1.1.zip - > unzip dbscSNV1.1.zip - > head -n1 dbscSNV1.1.chr1 > h - - # GRCh38 - > cat dbscSNV1.1.chr* | grep -v ^chr | sort -k5,5 -k6,6n | cat h - | bgzip -c > dbscSNV1.1_GRCh38.txt.gz - > tabix -s 5 -b 6 -e 6 -c c dbscSNV1.1_GRCh38.txt.gz - - # GRCh37 - > cat dbscSNV1.1.chr* | grep -v ^chr | cat h - | bgzip -c > dbscSNV1.1_GRCh37.txt.gz - > tabix -s 1 -b 2 -e 2 -c c dbscSNV1.1_GRCh37.txt.gz - - Note that in the last command we tell tabix that the header line starts with "c"; - this may change to the default of "#" in future versions of dbscSNV. - - Tabix also allows the data file to be hosted on a remote server. This plugin is - fully compatible with such a setup - simply use the URL of the remote file: - - --plugin dbscSNV,http://my.files.com/dbscSNV.txt.gz - - Note that transcript sequences referred to in dbscSNV may be out of sync with - those in the latest release of Ensembl; this may lead to discrepancies with - scores retrieved from other sources. - -=cut - -package dbscSNV; - -use strict; -use warnings; - -use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp); - -use Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepTabixPlugin); - -sub new { - my $class = shift; - - my $self = $class->SUPER::new(@_); - - $self->expand_left(0); - $self->expand_right(0); - - # get dbNSFP file - my $file = $self->params->[0]; - $self->add_file($file); - - if(my $assembly = $self->params->[1]) { - $self->{_param_assembly} = $assembly; - } - - # get headers - open HEAD, "tabix -fh $file 1:1-1 2>&1 | "; - while(<HEAD>) { - chomp; - $self->{headers} = [split]; - } - close HEAD; - - # check alt and Ensembl_transcriptid headers - foreach my $h(qw(alt Ensembl_gene)) { - die "ERROR: Could not find required column $h in $file\n" unless grep {$_ eq $h} @{$self->{headers}}; - } - - # check we have hg38_pos col, only present in dbscSNV >= 1.1 - if($self->pos_column eq 'hg38_pos') { - die("ERROR: Could not find hg38_pos column in $file\n") unless grep {$_ eq 'hg38_pos'} @{$self->{headers}}; - } - - $self->{cols} = { - 'ada_score' => 1, - 'rf_score' => 1 - }; - - return $self; -} - -sub feature_types { - return ['Transcript']; -} - -sub variation_feature_types { - return ['VariationFeature']; -} - -sub get_header_info { - return { - ada_score => 'dbscSNV ADA score', - rf_score => 'dbscSNV RF score' - } -} - -sub run { - my ($self, $tva) = @_; - - my $vf = $tva->variation_feature; - - return {} unless $vf->{start} eq $vf->{end}; - # return {} unless grep {$_->SO_term =~ /splic/} @{$tva->get_all_OverlapConsequences}; - - # get allele, reverse comp if needed - my $allele = $tva->variation_feature_seq; - reverse_comp(\$allele) if $vf->{strand} < 0; - - return {} unless $allele =~ /^[ACGT]$/; - - # get gene stable ID - my $g_id = $tva->transcript->{_gene_stable_id} || $tva->transcript->gene->stable_id; - - my $data; - my $pos_column = $self->pos_column; - - foreach my $tmp_data(@{$self->get_data($vf->{chr}, $vf->{start} - 1, $vf->{end})}) { - # compare allele and transcript - next unless - $tmp_data->{$pos_column} == $vf->{start} && - defined($tmp_data->{alt}) && - $tmp_data->{alt} eq $allele; # && - # defined($tmp_data->{Ensembl_gene}) && - # $tmp_data->{Ensembl_gene} =~ /$g_id($|;)/; - - $data = $tmp_data; - last; - } - - return {} unless scalar keys %$data; - - # get required data - my %return = - map {$_ => $data->{$_}} - grep {$data->{$_} ne '.'} # ignore missing data - grep {defined($self->{cols}->{$_})} # only include selected cols - keys %$data; - - return \%return; -} - -sub parse_data { - my ($self, $line) = @_; - - $line =~ s/\r$//g; - - my @split = split /\t/, $line; - - # parse data into hash of col names and values - my %data = map {$self->{headers}->[$_] => $split[$_]} (0..(scalar @{$self->{headers}} - 1)); - - return \%data; -} - -sub get_start { - return $_[1]->{$_[0]->pos_column}; -} - -sub get_end { - return $_[1]->{$_[0]->pos_column}; -} - -sub pos_column { - my $self = shift; - - # work out which column to use - unless(exists($self->{pos_column})) { - if(my $assembly = $self->{_param_assembly} || $self->{config}->{assembly}) { - if($assembly eq 'GRCh37') { - $self->{pos_column} = 'pos'; - } - elsif($assembly eq 'GRCh38') { - $self->{pos_column} = 'hg38_pos'; - } - else { - die("ERROR: Assembly \"$assembly\" is not compatible with this plugin\n"); - } - } - else { - die("ERROR: Could not establish which position column to use based on assembly; try setting assembly manually with --assembly\n"); - } - } - - return $self->{pos_column}; -} - -1; -
--- a/dir_plugins/miRNA.pm Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,119 +0,0 @@ -=head1 LICENSE - -Copyright [1999-2015] Wellcome Trust Sanger Institute and the EMBL-European Bioinformatics Institute -Copyright [2016-2018] EMBL-European Bioinformatics Institute - -Licensed under the Apache License, Version 2.0 (the "License"); -you may not use this file except in compliance with the License. -You may obtain a copy of the License at - - http://www.apache.org/licenses/LICENSE-2.0 - -Unless required by applicable law or agreed to in writing, software -distributed under the License is distributed on an "AS IS" BASIS, -WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. -See the License for the specific language governing permissions and -limitations under the License. - -=head1 CONTACT - - Ensembl <http://www.ensembl.org/info/about/contact/index.html> - -=cut - -=head1 NAME - - miRNA - -=head1 SYNOPSIS - - mv miRNA.pm ~/.vep/Plugins - ./vep -i variations.vcf --plugin miRNA - -=head1 DESCRIPTION - - A VEP plugin that determines where in the secondary structure of a miRNA a - variant falls. - -=cut - -package miRNA; - -use strict; -use warnings; - -use Bio::EnsEMBL::Variation::Utils::BaseVepPlugin; - -use base qw(Bio::EnsEMBL::Variation::Utils::BaseVepPlugin); - -sub feature_types { - return ['Transcript']; -} - -sub get_header_info { - my $self = shift; - return { - miRNA => 'SO term for miRNA component containing the variant' - } -} - -sub run { - my ($self, $tva) = @_; - - my $tv = $tva->transcript_variation; - my $tr = $tva->transcript; - - # obviously this only works for *RNA transcripts - return {} unless $tr->biotype =~ /RNA/; - - # and it only works if the TV falls in the cDNA - return {} unless $tv->cdna_start && $tv->cdna_end; - - # get attribute if already cached - my ($attrib) = @{$tr->get_all_Attributes('ncRNA')}; - - # bit of a cheat to get attrib if ncRNA attribute hasn't been cached - if(!$attrib && defined($self->{config}->{ta})) { - delete $tr->{attributes}; - $tr->{adaptor} = $self->{config}->{ta}; - ($attrib) = @{$tr->get_all_Attributes('ncRNA')}; - } - - return {} unless $attrib; - - # split out string to get coords and structure string - my ($start, $end, $struct) = split /\s+|\:/, $attrib->value; - return {} unless $struct && $struct =~ /[\(\.\)]+/; - - # variant not in given structure? - return { miRNA => 'None' } unless $tv->cdna_start <= $end && $tv->cdna_end >= $start; - - # parse out structure - my @struct; - while($struct =~ m/([\.\(\)])([0-9]+)?/g) { - my $num = $2 || 1; - push @struct, $1 for(1..$num); - } - - # get struct element types overlapped by variant - my %chars; - for my $pos($tv->cdna_start..$tv->cdna_end) { - $pos -= $start; - next if $pos < 0 or $pos > scalar @struct; - $chars{$struct[$pos]} = 1; - } - - # map element types to SO terms - my %map = ( - '(' => 'miRNA_stem', - ')' => 'miRNA_stem', - '.' => 'miRNA_loop' - ); - - return { - miRNA => join(",", sort map {$map{$_}} keys %chars) - }; -} - -1; -
--- a/dir_plugins/plugin_config.txt Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,898 +0,0 @@ -my $VEP_PLUGIN_CONFIG = { - "plugins" => [ - - ## PATHOGENICITY PREDICTIONS - ############################ - - # dbNSFP - # https://github.com/ensembl-variation/VEP_plugins/blob/master/dbNSFP.pm - # Requires tabix-indexed data file as first param - # Field names are listed below and rendered as a multi-selectable autocomplete text field - # Human, GRCh38 only (3.x), for GRCh37 use 2.9.x - { - "key" => "dbNSFP", - "label" => "dbNSFP", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "helptip" => "dbNSFP provides pathogenicity predictions for missense variants from various algorithms", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/dbNSFP.pm", - "requires_data" => 1, - "requires_install" => 1, - "params" => [ - #"/path/to/dbNSFP3.5a.txt.gz", - "@*" - ], - "species" => [ - "homo_sapiens" - ], - "form" => [ - { - "name" => "dbNSFP_fields", - "label" => "Fields to include", - "helptip" => "Fields to fetch from dbNSFP; hold down the Ctrl (Windows) / Command (Mac) button to select multiple options", - "value" => "", - 'type' => 'dropdown', - 'multiple' => 1, - 'style' => 'height:150px', - 'required' => 1, - 'notes' => 'Field descriptions in <a rel="external" href="https://drive.google.com/file/d/0B60wROKy6OqcNGJ2STJlMTJONk0/view">dbNSFP README</a>', - # "class" => "jquery-multiselect", - "values" => [ - # "chr", - # "pos(1-based)", - # "ref", - # "alt", - # "aaref", - # "aaalt", - # "rs_dbSNP150", - # "hg19_chr", - # "hg19_pos(1-based)", - # "hg18_chr", - # "hg18_pos(1-based)", - # "genename", - # "cds_strand", - # "refcodon", - # "codonpos", - "codon_degeneracy", - "Ancestral_allele", - "AltaiNeandertal", - "Denisova", - # "Ensembl_geneid", - # "Ensembl_transcriptid", - # "Ensembl_proteinid", - # "aapos", - # "SIFT_score", - # "SIFT_converted_rankscore", - # "SIFT_pred", - # "Uniprot_acc_Polyphen2", - # "Uniprot_id_Polyphen2", - # "Uniprot_aapos_Polyphen2", - # "Polyphen2_HDIV_score", - # "Polyphen2_HDIV_rankscore", - # "Polyphen2_HDIV_pred", - # "Polyphen2_HVAR_score", - # "Polyphen2_HVAR_rankscore", - # "Polyphen2_HVAR_pred", - "LRT_score", - "LRT_converted_rankscore", - "LRT_pred", - "LRT_Omega", - "MutationTaster_score", - "MutationTaster_converted_rankscore", - "MutationTaster_pred", - "MutationTaster_model", - "MutationTaster_AAE", - "MutationAssessor_UniprotID", - "MutationAssessor_variant", - "MutationAssessor_score", - "MutationAssessor_score_rankscore", - "MutationAssessor_pred", - "FATHMM_score", - "FATHMM_converted_rankscore", - "FATHMM_pred", - "PROVEAN_score", - "PROVEAN_converted_rankscore", - "PROVEAN_pred", - "Transcript_id_VEST3", - "Transcript_var_VEST3", - "VEST3_score", - "VEST3_rankscore", - "MetaSVM_score", - "MetaSVM_rankscore", - "MetaSVM_pred", - "MetaLR_score", - "MetaLR_rankscore", - "MetaLR_pred", - "Reliability_index", - "M-CAP_score", - "M-CAP_rankscore", - "M-CAP_pred", - "REVEL_score", - "REVEL_rankscore", - "MutPred_score", - "MutPred_rankscore", - "MutPred_protID", - "MutPred_AAchange", - "MutPred_Top5features", - "CADD_raw", - "CADD_raw_rankscore", - "CADD_phred", - "DANN_score", - "DANN_rankscore", - "fathmm-MKL_coding_score", - "fathmm-MKL_coding_rankscore", - "fathmm-MKL_coding_pred", - "fathmm-MKL_coding_group", - "Eigen_coding_or_noncoding", - "Eigen-raw", - "Eigen-phred", - "Eigen-PC-raw", - "Eigen-PC-phred", - "Eigen-PC-raw_rankscore", - "GenoCanyon_score", - "GenoCanyon_score_rankscore", - "integrated_fitCons_score", - "integrated_fitCons_score_rankscore", - "integrated_confidence_value", - "GM12878_fitCons_score", - "GM12878_fitCons_score_rankscore", - "GM12878_confidence_value", - "H1-hESC_fitCons_score", - "H1-hESC_fitCons_score_rankscore", - "H1-hESC_confidence_value", - "HUVEC_fitCons_score", - "HUVEC_fitCons_score_rankscore", - "HUVEC_confidence_value", - "GERP++_NR", - "GERP++_RS", - "GERP++_RS_rankscore", - "phyloP100way_vertebrate", - "phyloP100way_vertebrate_rankscore", - "phyloP20way_mammalian", - "phyloP20way_mammalian_rankscore", - "phastCons100way_vertebrate", - "phastCons100way_vertebrate_rankscore", - "phastCons20way_mammalian", - "phastCons20way_mammalian_rankscore", - "SiPhy_29way_pi", - "SiPhy_29way_logOdds", - "SiPhy_29way_logOdds_rankscore", - "1000Gp3_AC", - "1000Gp3_AF", - "1000Gp3_AFR_AC", - "1000Gp3_AFR_AF", - "1000Gp3_EUR_AC", - "1000Gp3_EUR_AF", - "1000Gp3_AMR_AC", - "1000Gp3_AMR_AF", - "1000Gp3_EAS_AC", - "1000Gp3_EAS_AF", - "1000Gp3_SAS_AC", - "1000Gp3_SAS_AF", - "TWINSUK_AC", - "TWINSUK_AF", - "ALSPAC_AC", - "ALSPAC_AF", - "ESP6500_AA_AC", - "ESP6500_AA_AF", - "ESP6500_EA_AC", - "ESP6500_EA_AF", - "ExAC_AC", - "ExAC_AF", - "ExAC_Adj_AC", - "ExAC_Adj_AF", - "ExAC_AFR_AC", - "ExAC_AFR_AF", - "ExAC_AMR_AC", - "ExAC_AMR_AF", - "ExAC_EAS_AC", - "ExAC_EAS_AF", - "ExAC_FIN_AC", - "ExAC_FIN_AF", - "ExAC_NFE_AC", - "ExAC_NFE_AF", - "ExAC_SAS_AC", - "ExAC_SAS_AF", - "ExAC_nonTCGA_AC", - "ExAC_nonTCGA_AF", - "ExAC_nonTCGA_Adj_AC", - "ExAC_nonTCGA_Adj_AF", - "ExAC_nonTCGA_AFR_AC", - "ExAC_nonTCGA_AFR_AF", - "ExAC_nonTCGA_AMR_AC", - "ExAC_nonTCGA_AMR_AF", - "ExAC_nonTCGA_EAS_AC", - "ExAC_nonTCGA_EAS_AF", - "ExAC_nonTCGA_FIN_AC", - "ExAC_nonTCGA_FIN_AF", - "ExAC_nonTCGA_NFE_AC", - "ExAC_nonTCGA_NFE_AF", - "ExAC_nonTCGA_SAS_AC", - "ExAC_nonTCGA_SAS_AF", - "ExAC_nonpsych_AC", - "ExAC_nonpsych_AF", - "ExAC_nonpsych_Adj_AC", - "ExAC_nonpsych_Adj_AF", - "ExAC_nonpsych_AFR_AC", - "ExAC_nonpsych_AFR_AF", - "ExAC_nonpsych_AMR_AC", - "ExAC_nonpsych_AMR_AF", - "ExAC_nonpsych_EAS_AC", - "ExAC_nonpsych_EAS_AF", - "ExAC_nonpsych_FIN_AC", - "ExAC_nonpsych_FIN_AF", - "ExAC_nonpsych_NFE_AC", - "ExAC_nonpsych_NFE_AF", - "ExAC_nonpsych_SAS_AC", - "ExAC_nonpsych_SAS_AF", - "gnomAD_exomes_AC", - "gnomAD_exomes_AN", - "gnomAD_exomes_AF", - "gnomAD_exomes_AFR_AC", - "gnomAD_exomes_AFR_AN", - "gnomAD_exomes_AFR_AF", - "gnomAD_exomes_AMR_AC", - "gnomAD_exomes_AMR_AN", - "gnomAD_exomes_AMR_AF", - "gnomAD_exomes_ASJ_AC", - "gnomAD_exomes_ASJ_AN", - "gnomAD_exomes_ASJ_AF", - "gnomAD_exomes_EAS_AC", - "gnomAD_exomes_EAS_AN", - "gnomAD_exomes_EAS_AF", - "gnomAD_exomes_FIN_AC", - "gnomAD_exomes_FIN_AN", - "gnomAD_exomes_FIN_AF", - "gnomAD_exomes_NFE_AC", - "gnomAD_exomes_NFE_AN", - "gnomAD_exomes_NFE_AF", - "gnomAD_exomes_SAS_AC", - "gnomAD_exomes_SAS_AN", - "gnomAD_exomes_SAS_AF", - "gnomAD_exomes_OTH_AC", - "gnomAD_exomes_OTH_AN", - "gnomAD_exomes_OTH_AF", - "gnomAD_genomes_AC", - "gnomAD_genomes_AN", - "gnomAD_genomes_AF", - "gnomAD_genomes_AFR_AC", - "gnomAD_genomes_AFR_AN", - "gnomAD_genomes_AFR_AF", - "gnomAD_genomes_AMR_AC", - "gnomAD_genomes_AMR_AN", - "gnomAD_genomes_AMR_AF", - "gnomAD_genomes_ASJ_AC", - "gnomAD_genomes_ASJ_AN", - "gnomAD_genomes_ASJ_AF", - "gnomAD_genomes_EAS_AC", - "gnomAD_genomes_EAS_AN", - "gnomAD_genomes_EAS_AF", - "gnomAD_genomes_FIN_AC", - "gnomAD_genomes_FIN_AN", - "gnomAD_genomes_FIN_AF", - "gnomAD_genomes_NFE_AC", - "gnomAD_genomes_NFE_AN", - "gnomAD_genomes_NFE_AF", - "gnomAD_genomes_OTH_AC", - "gnomAD_genomes_OTH_AN", - "gnomAD_genomes_OTH_AF", - "clinvar_rs", - "clinvar_clnsig", - "clinvar_trait", - "clinvar_golden_stars", - "Interpro_domain", - "GTEx_V6p_gene", - "GTEx_V6p_tissue" - ], - }, - ] - }, - - # CADD - # https://github.com/ensembl-variation/VEP_plugins/blob/master/CADD.pm - # Requires tabix-indexed data file as first param - # No other parameters so no form required - # data file currently only available for GRCh37 - { - "key" => "CADD", - "label" => "CADD", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "helptip" => "Combined Annotation Dependent Depletion (CADD) is a tool for scoring the deleteriousness of single nucleotide variants and insertion/deletion variants in the human genome. CADD integrates multiple annotations into one metric by contrasting variants that survived natural selection with simulated mutations.", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/CADD.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - #"/path/to/whole_genome_SNVs.tsv.gz" - ] - }, - - # FATHMM-MKL - # https://github.com/ensembl-variation/VEP_plugins/blob/master/FATHMM_MKL.pm - # Requires tabix-indexed data file as first param - # No other parameters so no form required - # data file currently only available for GRCh37 - { - "key" => "FATHMM_MKL", - "label" => "FATHMM-MKL", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "helptip" => "FATHMM-MKL predicts functional consequences of variants, both coding and non-coding.", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/FATHMM_MKL.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - #"/path/to/fathmm-MKL_Current.tab.gz" - ] - }, - - # GWAVA - # https://www.sanger.ac.uk/sanger/StatGen_Gwava - # Requires tabix-indexed BED data file from ftp://ftp.sanger.ac.uk/pub/resources/software/gwava/v1.0/VEP_plugin/ - # data file currently only available for GRCh37 - { - "key" => "Gwava", - "label" => "GWAVA", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "helptip" => "Retrieves precomputed Genome Wide Annotation of VAriants (GWAVA) scores for any variant that overlaps a known variant from the Ensembl variation database", - "plugin_url" => "ftp://ftp.sanger.ac.uk/pub/resources/software/gwava/v1.0/VEP_plugin/Gwava.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - "@*", - # "/path/to/gwava_scores.bed.gz" - ], - "form" => [ - { - "name" => "model", - "label" => "Model", - "type" => "dropdown", - "values" => [ - { "value" => "region", "caption" => "Region" }, - { "value" => "tss", "caption" => "TSS" }, - { "value" => "unmatched", "caption" => "Unmatched" } - ], - "value" => "region", - }, - ], - }, - - # Carol - # https://github.com/ensembl-variation/VEP_plugins/blob/master/Carol.pm - # Requires Math/CDF Perl module - { - "key" => "Carol", - "helptip" => "Calculates the Combined Annotation scoRing toOL (CAROL) score for a missense mutation based on the pre-calculated SIFT and PolyPhen scores", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Carol.pm", - "requires_install" => 1, - "species" => [ - "homo_sapiens" - ], - }, - - # Condel - # https://github.com/ensembl-variation/VEP_plugins/blob/master/Condel.pm - # Requires path to config directory as first param - # config directory is checked out as part of VEP_plugins repo, as /[path]/VEP_plugins/config/Condel/config - # Within that dir, edit condel_SP.conf so that condel.dir points to /[path]/VEP_plugins/config/Condel - { - "key" => "Condel", - "helptip" => "Calculates the Consensus Deleteriousness (Condel) score for a missense mutation based on the pre-calculated SIFT and PolyPhen scores", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Condel.pm", - "requires_install" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/config/Condel/config", - "@*" - ], - "form" => [ - { - "name" => "score_pred", - "label" => "Score/prediction", - "type" => "dropdown", - "values" => [ - { "value" => "b", "caption" => "Prediction and score" }, - { "value" => "p", "caption" => "Prediction only" }, - { "value" => "s", "caption" => "Score only" } - ], - "value" => "b", - }, - ], - }, - - # LOFTEE - # See https://github.com/konradjk/loftee for details - { - "key" => "LoF", - "helptip" => "LOFTEE identifies LoF (loss-of-function) variation", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/konradjk/loftee/master/LoF.pm", - "requires_data" => 1, - "requires_install" => 1, - "params" => [ - "@*" - ] - }, - - # LoFtool - # Requires LoFtool_scores.txt file as first param (available in VEP_plugins GitHub repo) - { - "key" => "LoFtool", - "helptip" => "Provides a per-gene rank of genic intolerance and consequent susceptibility to disease based on the ratio of Loss-of-function (LoF) to synonymous mutations in ExAC data", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/LoFtool.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/LoFtool_scores.txt" - ] - }, - - # ExACpLI - # Requires ExACpLI_values.txt file as first param (available in VEP_plugins GitHub repo) - { - "key" => "ExACpLI", - "helptip" => "Provides a per-gene probability of being loss-of-function intolerant (pLI) from ExAC data", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/ExACpLI.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/ExACpLI_values.txt" - ] - }, - - # MPC - # Requires fordist_constraint_official_mpc_values.txt.gz data file - { - "key" => "MPC", - "helptip" => "MPC is a missense deleteriousness metric based on the analysis of genic regions depleted of missense mutations in ExAC", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/MPC.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/fordist_constraint_official_mpc_values.txt.gz" - ] - }, - - # MTR - # Requires mtrflatfile_1.0.txt.gz data file from ftp://mtr-viewer.mdhs.unimelb.edu.au/pub - { - "key" => "MTR", - "helptip" => "MTR scores quantify the amount of purifying selection acting specifically on missense variants in a given window of protein-coding sequence", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/MTR.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/mtrflatfile_1.0.txt.gz" - ] - }, - - # REVEL - # Requires data file processed from revel_all_chromosomes.csv.zip - { - "key" => "REVEL", - "helptip" => "An ensemble method for predicting the pathogenicity of rare missense variants", - "available" => 0, - "enabled" => 0, - "section" => "Pathogenicity predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/REVEL.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/revel_all_chromosomes.tsv.gz" - ] - }, - - - - ## SPLICING PREDICTIONS - ####################### - - # dbscSNV - { - "key" => "dbscSNV", - "label" => "dbscSNV", - "available" => 0, - "enabled" => 0, - "section" => "Splicing predictions", - "helptip" => "Retrieves data for splicing variants from a tabix-indexed dbscSNV file", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/dbscSNV.pm", - "requires_data" => 1, - "requires_install" => 1, - "params" => [ - #"/path/to/dbscSNV1.1.txt.gz" - ], - "species" => [ - "homo_sapiens" - ], - }, - - # GeneSplicer - { - "key" => "GeneSplicer", - "label" => "GeneSplicer", - "helptip" => "Detects splice sites in genomic DNA", - "available" => 0, - "enabled" => 0, - "section" => "Splicing predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/GeneSplicer.pm", - "requires_install" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - #"/path/to/genesplicer/bin/linux/genesplicer", - #"/path/to/genesplicer/human", - "@*" - ] - }, - - # MaxEntScan - { - "key" => "MaxEntScan", - "label" => "MaxEntScan", - "helptip" => "Sequence motif and maximum entropy based splice site consensus predictions", - "available" => 0, - "enabled" => 0, - "section" => "Splicing predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/MaxEntScan.pm", - "requires_install" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - #"/path/to/maxentscan" - ] - }, - - # SpliceRegion - { - "key" => "SpliceRegion", - "label" => "SpliceRegion", - "helptip" => "More granular predictions of splicing effects", - "available" => 0, - "enabled" => 0, - "section" => "Splicing predictions", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/SpliceRegion.pm", - }, - - - ## CONSERVATION - ############### - - # Blosum62 - { - "key" => "Blosum62", - "label" => "BLOSUM62", - "helptip" => "BLOSUM62 amino acid conservation score", - "available" => 0, - "enabled" => 0, - "section" => "Conservation", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Blosum62.pm", - }, - - # Conservation - # Use the following query to get valid species sets: - # - # SELECT group_concat(concat("_stt_", gd.name) SEPARATOR ' '), REPLACE(mlss.name, "Gerp Conservation Scores ", ""), sst.value - # FROM method_link ml, - # method_link_species_set mlss, - # genome_db gd, species_set ss, species_set_tag sst - # WHERE mlss.method_link_id = ml.method_link_id AND - # mlss.species_set_id = ss.species_set_id AND - # ss.genome_db_id = gd.genome_db_id AND - # ss.species_set_id = sst.species_set_id AND - # (ml.class = "ConservationScore.conservation_score") - # GROUP BY mlss.species_set_id - { - "key" => "Conservation", - "helptip" => "Retrieves a conservation score from the Ensembl Compara databases for variant positions", - "available" => 0, - "enabled" => 0, - "section" => "Conservation", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Conservation.pm", - "params" => [ - "@*" - ], - "form" => [ - { - "name" => "method_link_type", - "label" => "Method", - "type" => "dropdown", - "values" => [ - { "value" => "GERP_CONSERVATION_SCORE", "caption" => "GERP"} - ] - }, - { - "name" => "species_set", - "label" => "Species set", - "type" => "dropdown", - "values" => [ - { "value" => "mammals", "caption" => "39 eutherian mammals" }, #"class" => "_stt_macaca_mulatta _stt_echinops_telfairi _stt_tupaia_belangeri _stt_erinaceus_europaeus _stt_sorex_araneus _stt_microcebus_murinus _stt_pongo_abelii _stt_equus_caballus _stt_ochotona_princeps _stt_cavia_porcellus _stt_choloepus_hoffmanni _stt_procavia_capensis _stt_tursiops_truncatus _stt_tarsius_syrichta _stt_dipodomys_ordii _stt_vicugna_pacos _stt_pteropus_vampyrus _stt_loxodonta_africana _stt_oryctolagus_cuniculus _stt_ailuropoda_melanoleuca _stt_nomascus_leucogenys _stt_callithrix_jacchus _stt_myotis_lucifugus _stt_bos_taurus _stt_gorilla_gorilla _stt_otolemur_garnettii _stt_pan_troglodytes _stt_ictidomys_tridecemlineatus _stt_sus_scrofa _stt_mus_musculus _stt_canis_familiaris _stt_mustela_putorius_furo _stt_felis_catus _stt_ovis_aries _stt_dasypus_novemcinctus _stt_homo_sapiens _stt_papio_anubis _stt_chlorocebus_sabaeus _stt_rattus_norvegicus" }, - { "value" => "amniotes", "caption" => "23 amniota vertebrates" }, #"class" => "_stt_macaca_mulatta _stt_ornithorhynchus_anatinus _stt_monodelphis_domestica _stt_pongo_abelii _stt_equus_caballus _stt_taeniopygia_guttata _stt_oryctolagus_cuniculus _stt_anolis_carolinensis _stt_meleagris_gallopavo _stt_callithrix_jacchus _stt_bos_taurus _stt_gorilla_gorilla _stt_pan_troglodytes _stt_sus_scrofa _stt_mus_musculus _stt_canis_familiaris _stt_felis_catus _stt_gallus_gallus _stt_ovis_aries _stt_homo_sapiens _stt_papio_anubis _stt_chlorocebus_sabaeus _stt_rattus_norvegicus" }, - { "value" => "sauropsids", "caption" => "7 sauropsids" }, #"class" => "_stt_taeniopygia_guttata _stt_anolis_carolinensis _stt_meleagris_gallopavo _stt_pelodiscus_sinensis _stt_gallus_gallus _stt_anas_platyrhynchos _stt_ficedula_albicollis" }, - { "value" => "fish", "caption" => "11 fish" }, #"class" => "_stt_takifugu_rubripes _stt_gasterosteus_aculeatus _stt_oryzias_latipes _stt_tetraodon_nigroviridis _stt_gadus_morhua _stt_oreochromis_niloticus _stt_xiphophorus_maculatus _stt_astyanax_mexicanus _stt_lepisosteus_oculatus _stt_poecilia_formosa _stt_danio_rerio" }, - ] - }, - ] - }, - - # AncestralAllele - # Requires processed FASTA file from ftp://ftp.ensembl.org/pub/current_fasta/ancestral_alleles/ - { - "key" => "AncestralAllele", - "label" => "Ancestral allele", - "helptip" => "Retrieves the ancestral allele for variants inferred from the Ensembl Compara Enredo-Pecan-Ortheus (EPO) pipeline", - "available" => 0, - "enabled" => 0, - "section" => "Conservation", - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/AncestralAllele.pm", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/homo_sapiens_ancestor_GRCh38_e93.fa.gz" - ] - }, - - - ## FREQUENCY DATA - ################# - - # ExAC - { - "key" => "ExAC", - "label" => "ExAC frequencies", - "helptip" => "Reports allele frequencies from the Exome Aggregation Consortium", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/ExAC.pm", - "section" => "Frequency data", - "requires_data" => 1, - "species" => [ - "homo_sapiens" - ], - "params" => [ - # "/path/to/ExAC.r0.3.sites.vep.vcf.gz" - ] - }, - - - ## OTHER - ######## - - # CSN - { - "key" => "CSN", - "helptip" => "Reports Clinical Sequencing Nomenclature (CSN) for variants", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/CSN.pm", - }, - - # miRNA - { - "key" => "miRNA", - "label" => "miRNA structure", - "helptip" => "Determines where in the secondary structure of a miRNA a variant falls", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/miRNA.pm", - }, - - - - # NearestGene - { - "key" => "NearestGene", - "label" => "Nearest gene", - "helptip" => "Finds the nearest gene to non-genic variants", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/NearestGene.pm", - }, - - # LD - { - "key" => "LD", - "label" => "Linkage disequilibrium", - "helptip" => "Finds variants in linkage disequilibrium with any overlapping existing variants from the Ensembl variation databases", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/LD.pm", - "section" => "Variant data", - "params" => [ - "@*" - ], - "form" => [ - { - "name" => "population", - "label" => "Population", - "type" => "dropdown", - "values" => [ - { "value" => "1000GENOMES:phase_3:ACB", "caption" => "African Caribbean in Barbados" }, - { "value" => "1000GENOMES:phase_3:ASW", "caption" => "African Ancestry in Southwest US" }, - { "value" => "1000GENOMES:phase_3:BEB", "caption" => "Bengali in Bangladesh" }, - { "value" => "1000GENOMES:phase_3:CDX", "caption" => "Chinese Dai in Xishuangbanna, China" }, - { "value" => "1000GENOMES:phase_3:CEU", "caption" => "Utah residents with Northern and Western European ancestry" }, - { "value" => "1000GENOMES:phase_3:CHB", "caption" => "Han Chinese in Bejing, China" }, - { "value" => "1000GENOMES:phase_3:CHS", "caption" => "Southern Han Chinese, China" }, - { "value" => "1000GENOMES:phase_3:CLM", "caption" => "Colombian in Medellin, Colombia" }, - { "value" => "1000GENOMES:phase_3:ESN", "caption" => "Esan in Nigeria" }, - { "value" => "1000GENOMES:phase_3:FIN", "caption" => "Finnish in Finland" }, - { "value" => "1000GENOMES:phase_3:GBR", "caption" => "British in England and Scotland" }, - { "value" => "1000GENOMES:phase_3:GIH", "caption" => "Gujarati Indian in Houston, TX" }, - { "value" => "1000GENOMES:phase_3:IBS", "caption" => "Iberian populations in Spain" }, - { "value" => "1000GENOMES:phase_3:ITU", "caption" => "Indian Telugu in the UK" }, - { "value" => "1000GENOMES:phase_3:JPT", "caption" => "Japanese in Tokyo, Japan" }, - { "value" => "1000GENOMES:phase_3:KHV", "caption" => "Kinh in Ho Chi Minh City, Vietnam" }, - { "value" => "1000GENOMES:phase_3:LWK", "caption" => "Luhya in Webuye, Kenya" }, - { "value" => "1000GENOMES:phase_3:MAG", "caption" => "Mandinka in The Gambia" }, - { "value" => "1000GENOMES:phase_3:MSL", "caption" => "Mende in Sierra Leone" }, - { "value" => "1000GENOMES:phase_3:MXL", "caption" => "Mexican Ancestry in Los Angeles, California" }, - { "value" => "1000GENOMES:phase_3:PEL", "caption" => "Peruvian in Lima, Peru" }, - { "value" => "1000GENOMES:phase_3:PJL", "caption" => "Punjabi in Lahore, Pakistan" }, - { "value" => "1000GENOMES:phase_3:PUR", "caption" => "Puerto Rican in Puerto Rico" }, - { "value" => "1000GENOMES:phase_3:STU", "caption" => "Sri Lankan Tamil in the UK" }, - { "value" => "1000GENOMES:phase_3:TSI", "caption" => "Toscani in Italy" }, - { "value" => "1000GENOMES:phase_3:YRI", "caption" => "Yoruba in Ibadan, Nigeria" }, - ], - "value" => "1000GENOMES:phase_3:CEU", - }, - { - "name" => "threshold", - "label" => "r2 cutoff", - "type" => "string", - "value" => 0.8, - }, - ] - }, - - # SameCodon - { - "key" => "SameCodon", - "label" => "Variants in same codon", - "helptip" => "Reports existing variants that fall in the same codon", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/SameCodon.pm", - "section" => "Variant data", - }, - # LOVD - { - "key" => "LOVD", - "label" => "LOVD", - "helptip" => "Retrieves LOVD variation data", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/LOVD.pm", - "section" => "Variant data", - }, - - # GO - { - "key" => "GO", - "label" => "Gene Ontology", - "helptip" => "Retrieves Gene Ontology terms associated with transcripts/translations via the Ensembl API", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/GO.pm", - "section" => "Gene data", - }, - - # Downstream - { - "key" => "Downstream", - "label" => "Downstream", - "helptip" => "Predicts the downstream effects of a frameshift variant on the protein sequence of a transcript", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Downstream.pm", - }, - - # ProteinSeqs - { - "key" => "ProteinSeqs", - "label" => "Protein sequences", - "helptip" => "Prints out the reference and mutated protein sequences of any proteins found with non-synonymous mutations", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/ProteinSeqs.pm", - }, - - # TSSDistance - { - "key" => "TSSDistance", - "label" => "TSS distance", - "helptip" => "Calculates the distance from the transcription start site for upstream variants ", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/TSSDistance.pm", - }, - - # Phenotypes - { - "key" => "Phenotypes", - "label" => "Phenotypes", - "helptip" => "Retrieves overlapping phenotype annotations", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Phenotypes.pm", - }, - # Draw - { - "key" => "Draw", - "label" => "Draw", - "helptip" => "Creates images of the transcript model showing variant location", - "available" => 0, - "enabled" => 0, - "requires_install" => 1, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/Draw.pm", - }, - # G2P - { - "key" => "G2P", - "label" => "G2P", - "helptip" => "Assesses variants using G2P allelic requirements for potential phenotype involvement.", - "available" => 0, - "enabled" => 0, - "requires_data" => 1, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/G2P.pm", - }, - - # LocalID - { - "key" => "LocalID", - "label" => "LocalID", - "helptip" => "Allows you to use variant IDs as VEP input without making a database connection.", - "available" => 0, - "enabled" => 0, - "plugin_url" => "https://raw.githubusercontent.com/Ensembl/VEP_plugins/release/94/LocalID.pm", - }, - - - ] -};
--- /dev/null Thu Jan 01 00:00:00 1970 +0000 +++ b/tool-data/vep_cache_data.loc.sample Mon Jul 15 05:19:31 2019 -0400 @@ -0,0 +1,7 @@ +# VEP data cache location +# <value> <dbkey> <type> <name> <path> +# <value> unique key of an entry (species_<type>) +# <dbkey> galaxy ref key +# <type> cache type, ensembl, refseq or merged +# <name> display name of the entry +# <path> path to the directory of the cache dir \ No newline at end of file
--- a/vep.xml Mon Jul 15 05:18:50 2019 -0400 +++ /dev/null Thu Jan 01 00:00:00 1970 +0000 @@ -1,563 +0,0 @@ -<tool id="vep" name="Vep" version="0.1.0"> - <requirements> - <requirement type="package" version="94.5">ensembl-vep</requirement> - </requirements> - <command detect_errors="exit_code"><![CDATA[ - #if str( $species.fields.type ) == "refseq": - #set $cache_type = "--refseq" - #elif str( $species.fields.type ) == "merged": - #set $cache_type = "--merged" - #else: - #set $cache_type = "" - #end if - - #if $output_options.cell_type.strip(): - #set $cell_type = '--cell_type ' + str( $output_options.cell_type ) - #else: - #set $cell_type = '' - #end if - - #if str( $output_options.individual.select ) == "all": - #set $individual = '--individual all' - #elif str( $output_options.individual.select ) == "ind": - #set $individual = '--individual ind ' + str($output_options.individual.list) - #else: - #set $individual = '' - #end if - - #if str( $output_options.vcf_info_field.select ) == "other": - #set $vcf_info_field = '--vcf_info_field ' + str( $output_options.vcf_info_field.name ) - #else - #set $vcf_info_field = '--vcf_info_field ' + str( $output_options.vcf_info_field.select ) - #end if - - #if str( $identifier_options.synonyms.select ) == "yes": - #set $synonyms = '--synonyms ' + str( $identifier_options.synonyms.file ) - #else - #set $synonyms = '' - #end if - - #if str( $filtering_qc.transcript_filter.select ) == "yes": - #set $transcript_filter = '--transcript_filter "' + str( $filtering_qc.transcript_filter.filter ) + '"' - #else: - #set $transcript_filter = '' - #end if - - #if str( $filtering_qc.chr.select ) == "yes": - #set chr = '--chr ' + str( $filtering_qc.chr.list ) - #else: - #set chr = '' - #end if - - #if str( $filtering_qc.pick_order.select ) == "yes": - #set $pick_order = '--pick_order ' + str( $filtering_qc.pick_order.list ) - #else: - #set $pick_order = '' - #end if - - #if str( $filtering_qc.freq.select ) == "yes": - #set $freq_pop = str( $filtering_qc.freq.freq_pop ) - #set $freq_freq = str( $filtering_qc.freq.freq_freq ) - #set $freq_gt_lt = str( $filtering_qc.freq.freq_gt_lt ) - #set $freq_filter = str( $filtering_qc.freq.freq_filter ) - #set $freq = $freq_pop + ' --freq_freq ' + $freq_freq + ' ' + $freq_gt_lt + ' ' + $freq_filter - #else: - #set $freq = '' - #end if - - vep - --format vcf - --VCF - --no_stats - --dir_plugins $__tool_directory__/dir_plugins - --cache - --dir_cache ${species.fields.path} - --force_overwrite - --species ${species.fields.dbkey} - $cache_type - --input_file "$input" - --output_file "$output" - $offline - $output_options.variant_class - $output_options.sift - $output_options.polyphen - $output_options.humdiv - $output_options.nearest - --distance $output_options.distance - $output_options.gene_phenotype - $output_options.regulatory - $cell_type - $individual - $vcf_info_field - $output_options.phased - $output_options.total_length - $output_options.numbers - $output_options.domains - $output_options.no_escape - $output_options.keep_csq - --terms $output_options.terms - $output_options.no_headers - $identifier_options.transcript_version - $identifier_options.protein - $identifier_options.symbol - $identifier_options.ccds - $identifier_options.tsl - $identifier_options.appris - $identifier_options.canonical - $identifier_options.biotype - $identifier_options.xref_refseq - $synonyms - $co_located_variants_options.check_existing - $co_located_variants_options.exclude_null_alleles - $co_located_variants_options.no_check_alleles - $co_located_variants_options.af - $co_located_variants_options.max_af - $co_located_variants_options.af_1kg - $co_located_variants_options.af_esp - $co_located_variants_options.af_gnomad - $co_located_variants_options.af_exac - $co_located_variants_options.pubmed - $co_located_variants_options.failed - $filtering_qc.gencode_basic - $filtering_qc.all_refseq - $filtering_qc.exclude_predicted - $transcript_filter - $filtering_qc.check_ref - $filtering_qc.lookup_ref - $chr - $filtering_qc.dont_skip - $filtering_qc.allow_non_variant - $filtering_qc.coding_only - $filtering_qc.no_intergenic - $filtering_qc.pick - $filtering_qc.pick_allele - $filtering_qc.pick_allele_gene - $filtering_qc.per_gene - $filtering_qc.flag_pick - $filtering_qc.flag_pick_allele - $filtering_qc.flag_pick_allele_gene - $pick_order - $filtering_qc.most_severe - $filtering_qc.summary - $filtering_qc.filter_common - $freq - #for $i, $s in enumerate( $other_anotations.plugins ) - --plugin $s.plugin - #end for - ]]></command> - <inputs> - <param type="data" name="input" format="vcf" /> - <param name="species" type="select"> - <options from_data_table="vep_cache_data"> - <validator type="no_options" message="Run the data manager to fetch cache data"/> - </options> - </param> - <param name="offline" type="select"> - <option value="--offline">Yes</option> - <option value="" selected="true">No</option> - </param> - <section name="output_options" title="Output options"> - <param name="variant_class" type="select"> - <option value="--variant_class">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="sift" type="select"> - <option value="--sift p">Prediction</option> - <option value="--sift s">Score</option> - <option value="--sift b">Both</option> - <option value="" selected="true">No</option> - </param> - <param name="polyphen" type="select"> - <option value="--polyphen p">Prediction</option> - <option value="--polyphen s">Score</option> - <option value="--polyphen b">Both</option> - <option value="" selected="true">No</option> - </param> - <param name="humdiv" type="select"> - <option value="--humdiv">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="nearest" type="select"> - <option value="--nearest transcript">Transcript</option> - <option value="--nearest gene">Gene</option> - <option value="--nearest symbol">Symbol</option> - <option value="" selected="true">No</option> - </param> - <param name="distance" type="text" value="5000"> - <validator type="regex" message="Has to be a number">\d+(,\d+)?</validator> - </param> - <param name="gene_phenotype" type="select"> - <option value="--gene_phenotype">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="regulatory" type="select"> - <option value="--regulatory">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="cell_type" type="text"/> - <conditional name="individual"> - <param name="select" type="select" label="individual"> - <option value="all">All</option> - <option value="ind">Individual/List</option> - <option value="no" selected="true">No</option> - </param> - <when value="ind"> - <param name="list" type="text" /> - </when> - </conditional> - - <param name="phased" type="select"> - <option value="--phased">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="total_length" type="select"> - <option value="--total_length">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="numbers" type="select"> - <option value="--numbers">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="domains" type="select"> - <option value="--domains">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="no_escape" type="select"> - <option value="--no_escape">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="keep_csq" type="select"> - <option value="--no_escape">Yes</option> - <option value="" selected="true">No</option> - </param> - <conditional name="vcf_info_field"> - <param name="select" type="select" label="vcf_info_field"> - <option value="CSQ" selected="true">CSQ</option> - <option value="ANN">ANN</option> - <option value="other">Other</option> - </param> - <when value="other"> - <param name="name" type="text" /> - </when> - </conditional> - <param name="terms" type="select"> - <option value="SO" selected="true">SO</option> - <option value="display">display</option> - <option value="NCBI">NCBI</option> - </param> - <param name="no_headers" type="select"> - <option value="--no_headers">Yes</option> - <option value="" selected="true">No</option> - </param> - </section> - - <section name="identifier_options" title="Identifiers options"> - <!-- TODO add hgvs --> - <!-- TODO add hgvsg --> - <!-- TODO add shift_hgvs --> - <param name="transcript_version" type="select"> - <option value="--transcript_version">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="protein" type="select"> - <option value="--protein">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="symbol" type="select"> - <option value="--symbol">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="ccds" type="select"> - <option value="--ccds">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="tsl" type="select"> - <option value="--tsl">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="appris" type="select"> - <option value="--appris">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="canonical" type="select"> - <option value="--canonical">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="biotype" type="select"> - <option value="--biotype">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="xref_refseq" type="select"> - <option value="--xref_refseq">Yes</option> - <option value="" selected="true">No</option> - </param> - <conditional name="synonyms"> - <param name="select" type="select" label="synonyms"> - <option value="yes">Yes</option> - <option value="no" selected="true">No</option> - </param> - <when value="yes"> - <param type="data" name="file" format="tabular" /> - </when> - </conditional> - </section> - - <section name="co_located_variants_options" title="Co-located variants options"> - <param name="check_existing" type="select"> - <option value="--check_existing">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="exclude_null_alleles" type="select"> - <option value="--exclude_null_alleles">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="no_check_alleles" type="select"> - <option value="--no_check_alleles">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="af" type="select"> - <option value="--af">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="max_af" type="select"> - <option value="--max_af">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="af_1kg" type="select"> - <option value="--af_1kg">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="af_esp" type="select"> - <option value="--af_esp">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="af_gnomad" type="select"> - <option value="--af_gnomad">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="af_exac" type="select"> - <option value="--af_exac">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="pubmed" type="select"> - <option value="--pubmed">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="failed" type="select"> - <option value="--failed 1">Yes</option> - <option value="--failed 0" selected="true">No</option> - </param> - </section> - - <section name="filtering_qc" title="Filtering and QC"> - <param name="gencode_basic" type="select"> - <option value="--gencode_basic">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="all_refseq" type="select"> - <option value="--all_refseq">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="exclude_predicted" type="select"> - <option value="--exclude_predicted">Yes</option> - <option value="" selected="true">No</option> - </param> - <conditional name="transcript_filter"> - <param name="select" type="select" label="transcript_filter"> - <option value="yes">Yes</option> - <option value="no" selected="true">No</option> - </param> - <when value="yes"> - <param type="text" name="filter"> - <sanitizer> - <valid initial="string.printable"> - <remove value="'" /> - </valid> - </sanitizer> - </param> - </when> - </conditional> - <param name="check_ref" type="select"> - <option value="--check_ref">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="lookup_ref" type="select"> - <option value="--lookup_ref">Yes</option> - <option value="" selected="true">No</option> - </param> - <conditional name="chr"> <!-- TODO double check, looks correct but doesn't seem to work --> - <param name="select" type="select" label="chr"> - <option value="yes">Yes</option> - <option value="no" selected="true">No</option> - </param> - <when value="yes"> - <param type="text" name="list" /> - </when> - </conditional> - <param name="dont_skip" type="select"> - <option value="" selected="true">Yes</option> - <option value="--dont_skip">No</option> - </param> - <param name="allow_non_variant" type="select"> - <option value="--allow_non_variant">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="coding_only" type="select"> - <option value="--coding_only">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="no_intergenic" type="select"> - <option value="--no_intergenic">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="pick" type="select"> - <option value="--pick">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="pick_allele" type="select"> - <option value="--pick_allele">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="pick_allele_gene" type="select"> - <option value="--pick_allele_gene">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="per_gene" type="select"> - <option value="--per_gene">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="flag_pick" type="select"> - <option value="--flag_pick">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="flag_pick_allele" type="select"> - <option value="--flag_pick_allele">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="flag_pick_allele_gene" type="select"> - <option value="--flag_pick_allele_gene">Yes</option> - <option value="" selected="true">No</option> - </param> - <conditional name="pick_order"> - <param name="select" type="select" label="pick_order"> - <option value="yes">Yes</option> - <option value="no" selected="true">No</option> - </param> - <when value="yes"> - <param type="text" name="list" /> - </when> - </conditional> - <param name="most_severe" type="select"> - <option value="--most_severe">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="summary" type="select"> <!-- TODO double check, looks correct but doesn't seem to work --> - <option value="--summary">Yes</option> - <option value="" selected="true">No</option> - </param> - <param name="filter_common" type="select"> - <option value="--filter_common">Yes</option> - <option value="" selected="true">No</option> - </param> - - <conditional name="freq"> - <param name="select" type="select" label="freq"> - <option value="yes">Yes</option> - <option value="no" selected="true">No</option> - </param> - <when value="yes"> - <param name="freq_pop" type="select"> - <option value="--freq_pop 1KG_ALL">1000 genomes combined population (global)</option> - <option value="--freq_pop 1KG_AFR">1000 genomes combined African population</option> - <option value="--freq_pop 1KG_AMR">1000 genomes combined American population</option> - <option value="--freq_pop 1KG_EAS">1000 genomes combined East Asian population</option> - <option value="--freq_pop 1KG_EUR">1000 genomes combined European population</option> - <option value="--freq_pop 1KG_SAS">1000 genomes combined South Asian population</option> - <option value="--freq_pop ESP_AA">NHLBI-ESP African American</option> - <option value="--freq_pop ESP_EA">NHLBI-ESP European American</option> - <option value="--freq_pop gnomAD">gnomAD combined population</option> - <option value="--freq_pop gnomAD_AFR">gnomAD African/African American population</option> - <option value="--freq_pop gnomAD_AMR">gnomAD Latino population</option> - <option value="--freq_pop gnomAD_ASJ">gnomAD Ashkenazi Jewish population</option> - <option value="--freq_pop gnomAD_EAS">gnomAD East Asian population</option> - <option value="--freq_pop gnomAD_FIN">gnomAD Finnish population</option> - <option value="--freq_pop gnomAD_NFE">gnomAD non-Finnish European population</option> - <option value="--freq_pop gnomAD_OTH">gnomAD other population</option> - <option value="--freq_pop gnomAD_SAS">gnomAD South Asian population</option> - </param> - <param type="text" name="freq_freq" /> - <param name="freq_gt_lt" type="select"> - <option value="--freq_gt_lt gt" selected="true">Greater</option> - <option value="--freq_gt_lt lt">Less than</option> - </param> - <param name="freq_filter" type="select"> - <option value="--freq_filter include" selected="true">Include</option> - <option value="--freq_gt_lt exclude">Exclude</option> - </param> - </when> - </conditional> - - <!-- TODO add check_frequency group --> - </section> - - <section name="other_anotations" title="Other anotations"> - <repeat name="plugins" title="Plugins" min="0" default="0"> - <param name="plugin" type="select" label="Plugin"> - <option value="AncestralAllele">AncestralAllele</option> - <option value="Blosum62">Blosum62</option> - <option value="CADD">CADD</option> - <option value="Carol">Carol</option> - <option value="CCDSFilter">CCDSFilter</option> - <option value="Condel">Condel</option> - <option value="Conservation">Conservation</option> - <option value="CSN">CSN</option> - <option value="DAS">DAS</option> - <option value="dbNSFP">dbNSFP</option> - <option value="dbscSNV">dbscSNV</option> - <option value="Downstream">Downstream</option> - <option value="Draw">Draw</option> - <option value="ExACpLI">ExACpLI</option> - <option value="ExAC">ExAC</option> - <option value="FATHMM_MKL">FATHMM_MKL</option> - <option value="FATHMM">FATHMM</option> - <option value="G2P">G2P</option> - <option value="GeneSplicer">GeneSplicer</option> - <option value="GO">GO</option> - <option value="GXA">GXA</option> - <option value="HGVSReferenceBase">HGVSReferenceBase</option> - <option value="LD">LD</option> - <option value="LocalID">LocalID</option> - <option value="LoFtool">LoFtool</option> - <option value="LOVD">LOVD</option> - <option value="MaxEntScan">MaxEntScan</option> - <option value="miRNA">miRNA</option> - <option value="MPC">MPC</option> - <option value="MTR">MTR</option> - <option value="NearestGene">NearestGene</option> - <option value="NonSynonymousFilter">NonSynonymousFilter</option> - <option value="Phenotypes">Phenotypes</option> - <option value="PolyPhen_SIFT">PolyPhen_SIFT</option> - <option value="PON_P2">PON_P2</option> - <option value="ProteinSeqs">ProteinSeqs</option> - <option value="RankFilter">RankFilter</option> - <option value="RefSeqHGVS">RefSeqHGVS</option> - <option value="REVEL">REVEL</option> - <option value="SameCodon">SameCodon</option> - <option value="SpliceRegion">SpliceRegion</option> - <option value="SubsetVCF">SubsetVCF</option> - <option value="TSSDistance">TSSDistance</option> - <option value="Wildtype">Wildtype</option> - </param> - </repeat> - </section> - - - - </inputs> - <outputs> - <data name="output" format="vcf" /> - </outputs> - <help><![CDATA[ - This is a straightforward tool wrapper for VEP, for more information about these parameters visit the VEP documentation: https://www.ensembl.org/info/docs/tools/vep/script/vep_options.html - ]]></help> -</tool> \ No newline at end of file